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Pediatric allergy

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https://www.readbyqxmd.com/read/28643898/identification-of-cross-reactive-b-cell-epitopes-between-bos-d-9-0101-bos-taurus-and-gly-m-5-0101-glycine-max-by-epitope-mapping-maldi-tof-ms
#1
Ángela María Candreva, Mario Ferrer-Navarro, Silvia Bronsoms, Alejandra Quiroga, Renata Curciarello, Ana Cauerhff, Silvana Petruccelli, Guillermo Horacio Docena, Sebastián Alejandro Trejo
Exposure to cow's milk constitutes one of the most common causes of food allergy. In addition, exposure to soy proteins has become relevant in a restricted proportion of milk allergic pediatric patients treated with soy formulae as a dairy substitute, because of the cross-allergenicity described between soy and milk proteins . We have previously identified several cross-reactive allergens between milk and soy that may explain this intolerance. The purpose of the present work was to identify epitopes in the purified αS1-casein and the recombinant soy allergen Gly m 5...
June 23, 2017: Proteomics
https://www.readbyqxmd.com/read/28642859/exercise-induced-bronchospasm-and-allergy
#2
REVIEW
Serena Caggiano, Renato Cutrera, Antonio Di Marco, Attilio Turchetta
Sport is an essential part of childhood, with precious and acknowledged positive health effects but the impact of exercise-induced bronchoconstriction (EIB) significantly reduces participation in physical activity. It is important to recognize EIB, differentiating EIB with or without asthma if the transient narrowing of the airways after exercise is associated with asthmatic symptoms or not, in the way to select the most appropriate treatment among the many treatment options available today. Therapy is prescribed based on symptoms severity but diagnosis of EIB is established by changes in lung function provoked by exercise evaluating by direct and indirect tests...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28638300/characteristics-of-pediatric-clinical-interventions-documented-by-a-school-of-pharmacy
#3
Lea S Eiland
OBJECTIVES: Documentation of interventions by pharmacists has become a standard of practice in clinical practice sites. Pharmacists' interventions in pediatric practice settings for short periods of time have been reported in the literature. A single study has described faculty and student interventions in the pediatric setting. The objective of this study was to characterize 4 years of interventions by faculty and students of a school of pharmacy that occurred at various pediatric practice sites throughout a state...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28628759/do-infants-with-cow-s-milk-protein-allergy-have-inadequate-levels-of-vitamin-d
#4
Cristiane M Silva, Silvia A da Silva, Margarida M de C Antunes, Gisélia Alves Pontes da Silva, Emanuel Sávio Cavalcanti Sarinho, Kátia G Brandt
OBJECTIVE: To verify whether infants with cow's milk protein allergy (CMPA) have inadequate vitamin D levels. METHODS: This cross-sectional study included 120 children aged 2 years or younger, one group with CMPA and a control group. The children were recruited at the pediatric gastroenterology, allergology, and pediatric outpatient clinics of a university hospital in the Northeast of Brazil. A questionnaire was administered to the caregiver and blood samples were collected for vitamin D quantification...
June 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28626380/clinical-and-pathologic-remission-of-pediatric-ulcerative-colitis-with-serum-derived-bovine-immunoglobulin-added-to-the-standard-treatment-regimen
#5
Rachelle A Soriano, Asuncion G Ramos-Soriano
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is particularly troublesome for pediatric patients, as current therapeutic options consist of biologic agents and steroids which alter the immune response and have the harmful side effect of leaving the patient more susceptible to opportunistic infections and eventual surgery. Another option for therapy exists in the form of serum-derived bovine immunoglobulin/protein isolate (SBI), the key ingredient in a medical food, EnteraGam®. The FDA has reviewed the safety of SBI and issued a no challenge letter to the generally recognized as safe (GRAS) findings for this medical food...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28603089/specific-allergen-immunotherapy-for-the-treatment-of-allergic-asthma-a-review-of-current-evidence
#6
J Dominguez-Ortega, J Delgado, C Blanco, L Prieto, E Arroabarren, M Cimarra, A Henriquez-Santana, J Iglesias-Souto, J M Vega-Chicote, A I Tabar
Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations...
June 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28599028/transitioning-the-allergy-immunology-patient-from-childhood-to-adulthood
#7
Flavia C L Hoyte
Allergic disorders and immunodeficiencies are generally chronic and even lifelong conditions, often changing over time, making the cautious transition of care from childhood to adulthood particularly important. Many, but not all, patients can continue to receive their care from the same physician as they transition through adolescence and emerging adulthood, made possible because allergy/immunology training programs require cross-training in the care of both pediatric and adult patients. Although keeping the same physician makes the transition easier for many allergy/immunology patients, even these patients face psychosocial issues unique to adolescents and emerging adults, including increased autonomy, risk-taking behavior, and medical self-management...
June 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28598588/nutritional-outcomes-in-infants-with-food-allergy-after-cardiac-surgery
#8
Wen-Yi Luo, Zhuo-Ming Xu, Li Hong, Qian-Yue Wu, Yue-Yue Zhang
BACKGROUND: Food allergy is a rapidly growing public health concern because of its increasing prevalence, as well as life-threatening potential. There is limited knowledge on the nutritional status for the pediatric congenital heart disease (CHD) patients with food allergy. OBJECTIVE: This study investigated both clinical and nutritional outcomes according to the CHD infants with food allergy. METHODS: Forty CHD infants with food allergy and 39 controls were recruited in Shanghai, China...
June 9, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28595764/food-allergy-and-anxiety-and-depression-among-ethnic-minority-children-and-their-caregivers
#9
Renee D Goodwin, Sandra Rodgin, Rachel Goldman, Juliana Rodriguez, Gabriele deVos, Denise Serebrisky, Jonathan M Feldman
OBJECTIVE: To investigate the relationship between food allergy and symptoms of anxiety and depression among ethnic minority, low socioeconomic status (SES) children and their caregivers. STUDY DESIGN: Pediatric patients ages 4-12 years with and without food allergy and their caregivers were recruited from urban pediatric outpatient clinics. Statistical analyses were used to examine the prevalence of symptoms of anxiety and depression among patients and their caregivers with and without food allergy, adjusting for asthma...
June 5, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28593864/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-ii
#10
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow´s milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Objectives: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
June 8, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28593863/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-i
#11
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow´s milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Objectives: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
June 6, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28553399/the-gut-brain-axis-a-new-pathogenic-view-of-neurologic-symptoms-description-of-a-pediatric-case
#12
Raffaele Falsaperla, Catia Romano, Piero Pavone, Giovanna Vitaliti, Qian Yuan, Nazgole Motamed-Gorji, Riccardo Lubrano
Recent literature data have given emphasis to the relationship between gastrointestinal (GI) disorders and neurologic diseases, underlying a new pathogenic pathway: The so-called "gut-brain axis." Herein, authors report a case of a 10-month-old male infant, admitted for drug-resistant epilepsy, associated with irritable behavior and GI discomfort, secondary to cow's milk protein allergy. Seizures were described by parents as upward eye movements that were mostly deviated to the right and were associated with slight extension of his neck...
January 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28550984/factors-associated-with-development-of-food-allergy-in-young-children-after-liver-transplantation-a-retrospective-analysis-of-10%C3%A2-years-experience
#13
Motoko Mitsui, Tetsuo Shoda, Osamu Natsume, Ichiro Nomura, Masami Narita, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Yukihiro Ohya
BACKGROUND: Although development of food allergy after liver transplantation is most commonly described in young children, little is known about identification of young liver-transplant recipients who are at risk of food allergy. OBJECTIVE: This study aimed to identify the types of food allergy and the risk factors for the development of food allergy after liver transplantation. METHODS: This was a retrospective analysis of pediatric liver transplant recipients in our organ transplantation center during 2005-2015...
May 24, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28549059/elimination-diet-and-the-development-of-multiple-tree-nut-allergies
#14
Arnon Elizur, Jennifer B Bollyky, Whitney M Block
BACKGROUNDDespite its high prevalence, relatively little is known about the characteristics of patients with multiple tree-nuts allergies.METHODSPatients (n=60, aged 4-15 years), recruited for a multiple food (tree-nuts, peanut, milk, egg, soy, sesame and wheat) oral immunotherapy (OIT) study, filled a questionnaire on their initial allergy evaluation. Medical records were reviewed. At OIT enrollment (median interval, 7.5 years), patients underwent oral food challenges (OFC) to foods still eliminated.RESULTSThere was significantly less evidence for eliminating tree-nuts compared to other foods, as reflected by lower rate of acute reaction to the offending food, either as the trigger for initial allergy evaluation (5...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28543769/perceptions-and-practices-regarding-atopic-dermatitis-a-survey
#15
Katherine R Grey, Kristen P Hook, Ingrid C Polcari, Sheilagh M Maguiness
Parents (N = 392) completed a survey at the Minnesota State Fair in August and September 2015 addressing knowledge regarding the pathogenesis of atopic dermatitis (AD), basic skin care practices, and the perceived role of infection and food allergies in AD. Of participating parents, 82% identified food allergy or sensitivity in AD pathogenesis, whereas only 42% identified bacterial infection as an important factor in AD severity. Participants most often received education on skin health from their pediatrician (49%), followed by Internet-based sources (23%), rather than a dermatologist or pediatric dermatologist...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28540285/allergen-avoidance-in-allergic-asthma
#16
REVIEW
Francesca Cipriani, Elisabetta Calamelli, Giampaolo Ricci
Allergic asthma is the most frequent disease among the chronic respiratory disorders in pediatric age with an important social impact. In the last years, many efforts have been made to identify effective preventive approaches to get a better control of symptoms and to obtain the best future outcomes for the patients. In patients with allergic asthma triggered by the exposure to indoor allergens, the avoidance is the first intervention to prevent the appearance or the worsening of bronchial symptoms. This review article summarized the most recent evidence from literature about the efficacy of specific control interventions for the most important allergens...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28537230/-allergy-and-autoimmunity-molecular-diagnostics-therapy-and-presumable-pathogenesis
#17
A S Arefieva, O V Smoldovskaya, A A Tikhonov, A Yu Rubina
Allergic and autoimmune diseases represent immunopathological reactions of an organism to antigens. Despite that the allergy is a result of exaggerated immune response to foreign antigens (allergens) and autoimmune diseases are characterized by the pathological response to internal antigens (autoantigens), the underlying mechanisms of these diseases are probably common. Thus, both types of diseases represent variations in the hypersensitivity reaction. A large percentage of both the adult and pediatric population is in need of early diagnostics of these pathologies of the immune system...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28521324/the-role-of-hydrolyzed-formula-in-allergy-prevention
#18
Michael D Cabana
Asthma, eczema, food allergy, and allergic rhinitis are some of the most common pediatric, chronic conditions in the world. Breastfeeding is the optimal way to feed all infants. For those infants who are exposed to infant formula, some studies suggest that certain partially hydrolyzed or extensively hydrolyzed formulas may decrease the risk of allergic disease compared to nonhydrolyzed formulas for children with a family history of atopic disease. Overall, there is some evidence to suggest that partially hydrolyzed whey formulas and extensively hydrolyzed casein formulas may decrease the risk of developing eczema for infants at high risk of allergic disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28521316/introduction-of-complementary-foods-to-infants
#19
Christina West
While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28497673/body-mass-index-and-skin-reactivity-to-histamine-and-dermatophagoides-pteronyssinus-in-children-and-adolescents-followed-in-a-pediatric-allergy-service
#20
A Keller Franco, R Oselka Sarni, M Carvalho Mallozi, D Solé
Rationale. Recent data suggest that the nutritional status assessed by body mass index (BMI) is positively associated with skin reactivity to histamine in children. Objective. To study the relation between BMI and skin reactivity to histamine and Dermatophagoides pteronyssinus in allergic children and adolescents. Methods. The medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. Only patients with asthma, allergic rhinitis or wheezing infants sensitized to at least one aeroallergen were selected: a total of 626 patients (6 months to 19 year-olds; 60...
May 2017: European Annals of Allergy and Clinical Immunology
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