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H Zöllner, R Jouni, S Panzer, A Khadour, L Janzen, J Wesche, M Ten Berg, S Schellong, A Heinken, A Greinacher, T Bakchoul
BACKGROUND: Protamine (PRT) is used to stabilize insulin in Neutral Protamine Hagedorn (NPH) insulin, a commonly used therapeutic agent for diabetes mellitus. Immunization against PRT/heparin-complexes is common in diabetic patients. OBJECTIVES: To investigate the impact of NPH-insulin on the interaction between anti-PRT/heparin antibodies and platelets. METHODS: The interaction between NPH-insulin and anti-PRT/heparin antibodies was tested using in-house enzyme immunoassays...
October 19, 2016: Journal of Thrombosis and Haemostasis: JTH
Ignacio Jusué-Torres, Lee H Jeon, Eric W Sankey, Jennifer Lu, Tito Vivas-Buitrago, Joshua A Crawford, Mikhail V Pletnikov, Jiadi Xu, Ari Blitz, Daniel A Herzka, Barbara Crain, Alicia Hulbert, Hugo Guerrero-Cazares, Oscar Gonzalez-Perez, James P McAllister, Alfredo Quiñones-Hinojosa, Daniele Rigamonti
BACKGROUND: The pathogenesis of adult chronic hydrocephalus is not fully understood, and the temporal relationship between development of the radiological changes and neurological deterioration is unknown. OBJECTIVE: To clarify the progression of radiological-histological changes and subsequent clinical manifestations of adult chronic hydrocephalus. METHODS: Kaolin was injected bilaterally into the subarachnoid space overlying the cranial convexities in 20 adult rats...
November 2016: Neurosurgery
Antti J Luikku, Anette Hall, Ossi Nerg, Anne M Koivisto, Mikko Hiltunen, Seppo Helisalmi, Sanna-Kaisa Herukka, Anna Sutela, Maria Kojoukhova, Jussi Mattila, Jyrki Lötjönen, Jaana Rummukainen, Irina Alafuzoff, Juha E Jääskeläinen, Anne M Remes, Hilkka Soininen, Ville Leinonen
OBJECTIVES: Optimal selection of idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery is challenging. Disease State Index (DSI) is a statistical method that merges multimodal data to assist clinical decision-making. It has previously been shown to be useful in predicting progression in mild cognitive impairment and differentiating Alzheimer's disease (AD) and frontotemporal dementia. In this study, we use the DSI method to predict shunt surgery response for patients with iNPH...
October 14, 2016: Acta Neurochirurgica
Sung-Hee Kim, David S Zee, Sascha du Lac, Hyo Jung Kim, Ji-Soo Kim
OBJECTIVE: To describe the ocular motor abnormalities in 9 patients with a lesion involving the nucleus prepositus hypoglossi (NPH), a key constituent of a vestibular-cerebellar-brainstem neural network that ensures that the eyes are held steady in all positions of gaze. METHODS: We recorded eye movements, including the vestibulo-ocular reflex during head impulses, in patients with vertigo and a lesion involving the NPH. RESULTS: Our patients showed an ipsilesional-beating spontaneous nystagmus, horizontal gaze-evoked nystagmus more intense on looking toward the ipsilesional side, impaired pursuit more to the ipsilesional side, central patterns of head-shaking nystagmus, contralateral eye deviation, and decreased vestibulo-ocular reflex gain during contralesionally directed head impulses...
October 12, 2016: Neurology
John J Kiernicki, Maryline G Ferrier, Juan S Lezama Pacheco, Henry S La Pierre, Benjamin W Stein, Matthias Zeller, Stosh A Kozimor, Suzanne C Bart
Arylazide and diazene activation by highly reduced uranium(IV) complexes bearing trianionic redox-active pyridine(diimine) ligands, [Cp(P)U((Mes)PDI(Me))]2 (1-Cp(P)), Cp*U((Mes)PDI(Me))(THF) (1-Cp*) (Cp(P) = 1-(7,7-dimethylbenzyl)cyclopentadienide; Cp* = η(5)-1,2,3,4,5-pentamethylcyclopentadienide), and Cp*U((t)Bu-(Mes)PDI(Me)) (THF) (1-(t)Bu) (2,6-((Mes)N═CMe)2-p-R-C5H2N, Mes = 2,4,6-trimethylphenyl; R = H, (Mes)PDI(Me); R = C(CH3)3, (t)Bu-(Mes)PDI(Me)), has been investigated. While 1-Cp* and 1-Cp(P) readily reduce N3R (R = Ph, p-tolyl) to form trans-bis(imido) species, Cp(P)U(NAr)2((Mes)PDI(Me)) (Ar = Ph, 2-Cp(P); Ar = p-Tol, 3-Cp(P)) and Cp*U(NPh)2((Mes)PDI(Me)) (2-Cp*), only 1-Cp* can cleave diazene N═N double bonds to form the same product...
October 12, 2016: Journal of the American Chemical Society
Emilio Luis González-Martínez, David Santamarta
BACKGROUND: Late-onset idiopathic aqueductal stenosis may present with clinical features indistinct from idiopathic normal-pressure hydrocephalus (NPH). Moreover, aqueductal stenosis (AS) is not always detected by conventional magnetic resonance imaging (MRI). The aim of this study was to compare the hydrodynamic pattern among NPH patients according to the patency of the aqueduct. METHODS: Fifty-six consecutive lumbar infusion tests were performed in patients with NPH syndrome...
October 11, 2016: Acta Neurochirurgica
B S Bal, Ashok Duggal, Mandeep Kaur, Umar Farooq, Harman Preet Singh
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
S J Jacober, M J Prince, J M Beals, M L Hartman, Y Qu, H Linnebjerg, P Garhyan, A Haupt
Basal insulin peglispro (BIL) is a novel basal insulin with a flat, prolonged activity profile. BIL has been demonstrated in a dog model, in healthy men and in patients with type 1 diabetes (T1D) to have significant hepato-preferential action resulting from reduced peripheral activity. In the IMAGINE-Phase 3 clinical trial program, more than 6000 patients were included, of whom ~3900 received BIL. Of the 7 pivotal IMAGINE trials, 3 studies were double-blinded and 3 were in T1D patients. BIL consistently demonstrated a greater HbA1c reduction, less glycaemic variability and a clinically relevant reduction in the rates of nocturnal hypoglycaemia across comparator [glargine and isophane insulin (NPH)] studies...
October 2016: Diabetes, Obesity & Metabolism
G Grunberger, L Chen, A Rodriguez, F J Tinahones, S J Jacober, J Bue-Valleskey
AIMS: Basal insulin peglispro (BIL) has a longer duration of action than conventional insulin analogues and a hepato-preferential mechanism of action. This study assessed whether BIL was non-inferior to isophane insulin (NPH) in reducing HbA1c in insulin-naïve patients with type 2 diabetes, when added to pre-study oral anti-hyperglycaemic medications. MATERIALS AND METHODS: This was a Phase 3, open-label, treat-to-target (TTT), randomized trial with a 2-week lead-in, 26-week treatment and a 4-week safety follow-up period...
October 2016: Diabetes, Obesity & Metabolism
Isabel G Albuerne, M Angeles Alvarez, Inmaculada Amor, M Esther García, Daniel García-Vivó, Miguel A Ruiz
The title phosphinidene complex reacted at room temperature with CS2 and SCNPh to give the phosphanyl derivatives [Mo2Cp{μ-κ(2)P,S:κ(1)S',η(5)-P(CS2)C5H4}(CO)2(η(6)-HMes*)] and [Mo2Cp{μ-κ(2)P,S:κ(1)P,η(5)-P(C(NPh)S)C5H4}(CO)2(η(6)-HMes*)], respectively (Mes* = 2,4,6-C6H2(t)Bu3), which result from a [2 + 2] cycloaddition of a C═S bond in the organic reagent to the Mo═P bond of the phosphinidene complex, with further insertion of S into the remaining Mo-P bond, in the CS2 reaction. The title complex also reacted with diazoalkanes N2CRR' at room temperature to give the corresponding phosphaalkene derivatives [Mo2Cp{μ-η(2):κ(1)P,η(5)-P(CRR')C5H4}(CO)2(η(6)-HMes*)] (CRR' = CH2, CPh2, CH(SiMe3))...
October 6, 2016: Inorganic Chemistry
Uygur Er, Çetin Akyol, Murad Bavbek
Aim of this paper is to present and discuss a case of a delayed cerebellar parenchymal hemorrhage developing after L/P shunt placement with a NPH patient. A hypertensive patient admitted to our clinic with a diagnosis of NPH. The patient was placed a pressure adjustable L/P shunt without any surgical complication. He was discharged with an uneventful period. The patient was admitted to the emergency clinic of our hospital with a 1.5 × 1.5 cm diameter hematoma at the left cerebellar hemisphere on 2 days after his discharge...
October 2016: Asian Journal of Neurosurgery
Claudia L Craven, Ahmed K Toma, Tarek Mostafa, Neekhil Patel, Laurence D Watkins
OBJECTIVE: Selecting probable idiopathic normal pressure hydrocephalus (INPH) patients for shunt insertion presents a challenge because of coexisting comorbidities and other conditions that could mimic NPH. The characteristic appearance of DESH (Disproportionately Enlarged Subarachnoid Space Hydrocephalus) on brain imaging has been shown to have a high positive predictive value in identifying shunt responsive INPH patients (SINPHONI trial). However, the negative predictive value of this radiological sign was not clearly demonstrated...
September 28, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Itziar Zumeta, Claudio Mendicute-Fierro, Itxaso Bustos, Miguel A Huertos, Antonio Rodríguez-Diéguez, José M Seco, Eider San Sebastian, María A Garralda
Unprecedented metallapyrazoles [IrH2{Ph2P(o-C6H4)CNNHC(o-C6H4)PPh2}] (3) and [IrHCl{Ph2P(o-C6H4)CNNHC(o-C6H4)PPh2}] (4) were obtained by the reaction of the irida-β-ketoimine [IrHCl{(PPh2(o-C6H4CO))(PPh2(o-C6H4CNNH2))H}] (2) in MeOH heated at reflux in the presence and absence of KOH, respectively. In solution, iridapyrazole 3 undergoes a dynamic process due to prototropic tautomerism with an experimental barrier for the exchange of ΔGcoal(⧧) = 53.7 kJ mol(-1). DFT calculations agreed with an intrapyrazole proton transfer process assisted by two water molecules (ΔG = 63...
October 17, 2016: Inorganic Chemistry
Sabina Ranjit, Narasimha M Midde, Namita Sinha, Benjamin J Patters, Mohammad A Rahman, Theodore J Cory, P S S Rao, Santosh Kumar
BACKGROUND: Benzo(a)pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo(a)antharacene (BeA), and benzo(b)fluoranthene (BeF) are known carcinogenic polyaryl hydrocarbons (PAHs) present in cigarette smoke. This study was designed to examine the relative effect of these constituents on the cytotoxicity of monocytic cells and the possible mechanism of PAH-mediated cytotoxicity. METHODS: We examined the acute (6-24 hours) and chronic (7 days) effects of these PAHs on the expression of cytochromes P450 (CYPs), oxidative stress, and cytotoxicity...
2016: PloS One
Vladimir Makarov, Lidia Zueva, Tatiana Golubeva, Elena Korneeva, Igor Khmelinskii, Mikhail Inyushin
[This corrects the article DOI: 10.1117/1.NPh.4.1.011005.].
January 2017: Neurophotonics
Grant A Bateman, Jeannette Lechner-Scott, Rodney A Lea
BACKGROUND: It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matter. Limited data exists indicating there is an alteration in pulse wave propagation within the craniospinal cavity in MS, similar to the findings in normal pressure hydrocephalus (NPH). It is hypothesized MS may harbor pulse wave encephalopathy. The purpose of this study is to compare blood flow and pulse wave measurements in MS patients with a cohort of NPH patients and control subjects, to test this hypothesis...
2016: Fluids and Barriers of the CNS
A Chico, L Herranz, R Corcoy, O Ramírez, M M Goya, J Bellart, S González-Romero, M Codina, P Sánchez, A Cortázar, D Acosta, M J Picón, J A Rubio, A Megía, M A Sancho, M Balsells, E Solá, N L González, J López-López
OBJECTIVE: To examine the potential role of the type of basal insulin on glycemic control and maternal and foetal outcomes in pregnant women with type 1 diabetes (T1DM). STUDY DESIGN: Retrospective cohort study of pregnancies attended at 18 Spanish tertiary hospitals. INCLUSION CRITERIA: T1DM, singleton pregnancies, delivery between 2002-2010, and use of the same basal and prandial insulin from before pregnancy until delivery. RESULTS: A total of 1534 pregnancies were included...
September 9, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Conrad Johanson, Nancy Johanson
Robust modeling of CNS transport integrates molecular fluxes at the microvascular blood-brain barrier and epithelial choroid plexus blood-CSF barrier. Normal activity of solute transporters, channels and aquaporins, in the cerebral endothelium and choroidal epithelium, sets the microenvironment composition for neurons and glia. Conversely, perturbed transport/permeability at the barrier interfaces causes interstitial fluid dyshomeostasis (e.g. edema) arising in neural disorders. Critically-important transependymal solute/water distribution between brain and CSF needs more attention...
September 15, 2016: CNS & Neurological Disorders Drug Targets
Huan Zhang, Pan Wang, Ai-Jun Zhang, Xuan Li, Ji-Hong Zhang, Qi-Lian Qin, Yi-Jun Wu
The housefly is an important resource insect and the housefly larvae are ideal source of food additives. The housefly larvae protein hydrolysates were obtained by enzymatic hydrolysis by alcalase and neutral proteinase. Their antioxidant activities were investigated, including the superoxide and hydroxyl radicalscavenging activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, reducing power and metal chelating activity. The antioxidant activities of both hydrolysates increased with their increasing concentrations...
September 2016: Acta Biologica Hungarica
Jianqiu Gu, Xin Meng, Yan Guo, Lei Wang, Hongzhi Zheng, Yixuan Liu, Bingshu Wu, Difei Wang
Liraglutide, a glucagon-like peptide (GLP-1) receptor agonist, has showed favorable effects in the glycaemic control and weight reduction in patients with type 2 diabetes mellitus (T2DM). The meta-analysis was to compare the efficacy and safety of liraglutide added to metformin with other treatments in patients with T2DM. A systematic literature search on PubMed, Embase, Web of Science and the Cochrane library databases were performed. Eligible studies were randomized controlled trials (RCTs) of patients with T2DM who received the combination treatment of liraglutide and metformin...
2016: Scientific Reports
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