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https://www.readbyqxmd.com/read/29772402/serious-adverse-events-following-normal-pressure-hydrocephalus-surgery
#1
Vikas Kotagal, Elizabeth Walkowiak, Jason A Heth
OBJECTIVE: Recent Normal Pressure Hydrocephalus (NPH) practice guidelines describe a serious adverse event (SAE) rate following surgery of 11%. PATIENTS & METHODS: We conducted a retrospective review of 162 consecutive patients who have undergone work-up at our center's multidisciplinary NPH clinic over a 47 month time period (2/2014-12/2017). Of these, 22 ultimately underwent neurosurgical ventricular shunt surgery as treatment for NPH. Clinical records were reviewed for SAEs categorized as possibly/probably/definitely related to NPH surgery...
May 14, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29770552/variability-of-insulin-degludec-and-glargine-u300-a-matter-of-methodology-or-just-marketing
#2
Tim Heise, Sascha Heckermann, J Hans DeVries
The variability in the time-action profiles of insulin preparations, in particular basal insulins, has been a matter of debate ever since the publication of a glucose clamp study comparing the day-to-day variability of three different basal insulins (glargine U100, detemir and NPH) in 2004 [1]. While critics did not contest the findings of a lower variability of some basal insulins in this and a later [2] glucose clamp study, they did question the relevance of a lower pharmacokinetic (PK) and pharmacodynamic (PD) variability for clinical endpoints [3, 4]...
May 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29763560/on-the-mechanism-of-ti-catalyzed-oxidative-nitrene-transfer-in-2-2-1-pyrrole-synthesis-from-alkynes-and-azobenzene
#3
Zachary W Davis-Gilbert, Xuelan Wen, Jason D Goodpaster, Ian A Tonks
A combined computational and experimental study on the mechanism of Ti-catalyzed formal [2+2+1] pyrrole synthesis from alkynes and aryl diazenes is reported. This reaction proceeds through a formally Ti(II)/Ti(IV) redox catalytic cycle as determined by natural bond orbital (NBO) and intrinsic bond orbital (IBO) analysis. Kinetic analysis of the reaction of internal alkynes with azobenzene reveals a complex equilibria involving Ti=NPh monomer/dimer equilibrium, Ti=NPh + alkyne [2+2] cycloaddition equilibrium, along with azobenzene and pyridine inhibition equilibria prior to rate determining 2nd alkyne insertion...
May 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29741669/prevalence-of-schizophrenia-in-idiopathic-normal-pressure-hydrocephalus
#4
Vasco Vanhala, Antti Junkkari, Ville E Korhonen, Mitja I Kurki, Mikko Hiltunen, Tuomas Rauramaa, Ossi Nerg, Anne M Koivisto, Anne M Remes, Jonna Perälä, Jaana Suvisaari, Soili M Lehto, Heimo Viinamäki, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and potentially treatable neurodegenerative disease affecting elderly people, characterized by gait impairment and ventricular enlargement in brain imaging. Similar findings are seen in some patients with schizophrenia (SCZ). OBJECTIVE: To determine the prevalence of SCZ among patients suffering from probable or possible iNPH and the specific effects of comorbid SCZ on the outcome of the cerebrospinal fluid (CSF) shunting...
May 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29723726/the-quest-for-predicting-sustained-shunt-response-in-normal-pressure-hydrocephalus-an-analysis-of-the-callosal-angle-s-utility
#5
Kurt Grahnke, Ignacio Jusue-Torres, Caroline Szujewski, Cara Joyce, Michael Schneck, Vikram Prabhu, Douglas Anderson
BACKGROUND: Diagnosing normal pressure hydrocephalus (NPH) and selecting patients who will experience a sustained benefit from fluid diversion surgery remains challenging. This study seeks to evaluate the association between the callosal angle (CA) and the long-term post-operative response to ventriculoperitoneal shunt (VPS) surgery in a different subgroup population than previously studied to assess its generalizability. METHODS: We studied 73 patients with idiopathic NPH who underwent VPS surgery and had at least 18 months of follow-up between 2000-2016...
April 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29713649/treatment-discontinuation-and-clinical-events-in-type-2-diabetes-patients-treated-with-dipeptidyl-peptidase-4-inhibitors-or-nph-insulin-as-third-line-therapy
#6
Cristiano S Moura, Zale B Rosenberg, Michal Abrahamowicz, Sasha Bernatsky, Hassan Behlouli, Louise Pilote
Objective: To compare dipeptidyl peptidase-4 (DPP-4) inhibitors with neutral protamine Hagedorn (NPH) insulin, in terms of effectiveness and safety for the management of patients with type 2 diabetes mellitus (DM2) not controlled on metformin and sulfonylureas. Methods: A retrospective cohort study of individuals with DM2 newly dispensed with either DPP-4 inhibitors or NPH as third-line therapy, after metformin and sulfonylurea. Treatment discontinuation, macrovascular outcomes, and hypoglycemia were compared using multivariable Cox regression models, adjusted for sex, age, year of cohort entry, place of residence, hypertension, past history of hypoglycemia, diabetic ketoacidosis, comorbidities, and number of visits to emergency departments, outpatient physician, and hospitalizations...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29710738/medico-legal-implications-of-hypothermic-neuroprotection-in-the-newborn
#7
S M Donn, J M Fanaroff
Hypoxic-ischemic encephalopathy (HIE) continues to be a significant source of long term neurological sequelae in infants born at or near term. In the past decade, selective head or whole body cooling has shown promising benefit in ameliorating some of the brain injury from intrapartum asphyxial insults and has become standard care in most developed countries. A decision to offer neuroprotective hypothermia (NPH) may engender subsequent litigation because it presupposes an acute intrapartum injury. Conversely, failing to offer cooling may be interpreted as a violation in the standard of care...
April 24, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29709085/strong-preference-of-the-redox-neutral-mechanism-over-the-redox-mechanism-for-the-ti-iv-catalysis-involved-in-the-carboamination-of-alkyne-with-alkene-and-diazene
#8
Jiandong Guo, Yu Lu, Ruihua Zhao, Zheyuan Liu, Wasihun Menberu, Zhi-Xiang Wang
Titanium catalysis generally prefers redox-neutral mechanisms. Yet it has been reported that titanium could promote bond formations in a way similar to reductive elimination. Accordingly, redox catalytic cycles involving TiIV /TiII cycling have been considered. By studying, as an example, the carboamination of alkynes with alkenes and azobenzene catalyzed by the [TiIV ]=NPh imido complex, we performed DFT computations to gain an understanding of how the "abnormal" catalysis takes place, thereby allowing us to clarify whether the catalysis really follows TiIV /TiII redox mechanisms...
April 30, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29707227/diabetes-mellitus-remission-in-a-cat-with-pituitary-dependent-hyperadrenocorticism-after-trilostane-treatment
#9
Adriana Cunha Muschner, Fernanda Venzon Varela, Katarina Hazuchova, Stijn Jm Niessen, Álan Gomes Pöppl
Case summary: An 8-year-old male neutered Persian cat was presented with polyuria, polydipsia, polyphagia and muscle weakness associated with a 7 month history of diabetes mellitus (DM). The cat had initially been treated with neutral protamine Hagedorn (NPH) insulin 2 U q12h, followed by porcine lente insulin 2 U q12h and, most recently, 3 U glargine insulin q12h, without improvement of clinical signs. The cat also suffered from concurrent symmetrical bilateral alopecia of thorax and forelimbs, abdominal distension and lethargy...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29692348/effects-of-insulin-and-analogues-on-carcinogen-induced-mammary-tumours-in-high-fat-fed-rats
#10
Yusaku Mori, Eunhyoung Ko, Rudolf Furrer, Linda C Qu, Stuart C Wiber, George I Fantus, Mario Thevis, Alan Medline, Adria Giacca
It is not fully clarified whether insulin glargine, an analogue with a high affinity for insulin-like growth factor 1 receptor (IGF-1R), increases the risk for cancers that abundantly express IGF-1R such as breast cancer or some types of breast cancer. To gain insight into this issue, female Sprague-Dawley rats fed a high-fat diet were given the carcinogen N-Methyl-N-nitrosourea and randomly assigned to vehicle (control), NPH (unmodified human insulin), glargine, or detemir (n=30 per treatment). Insulins were given subcutaneously (15 U kg-1 day-1) 5 days a week...
April 24, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29689731/magnetoencephalography-and-normal-pressure-hydrocephalus-a-case-report
#11
A Kotini, T Birbilis, P Anninos, I Seimenis
A 82-year-old male experiencing headaches, dementia, urinary incontinence and gait instability was diagnosed with normal pressure hydrocephalus (NPH) and underwent a resting state magnetoencephalography (MEG) examination. MEG data were recorded in a magnetically shielded room with a whole-head 122 channel biomagnetometer. Following MEG, a ventriculoperitoneal (VP) shunt was placed in his head and greatly improved his symptomatology. Spontaneous MEG recordings revealed lower magnetic fields at frontal and frontotemporal regions compared to central and posterior regions...
April 18, 2018: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29669386/the-essential-ectoenzyme-smnpp5-from-the-human-intravascular-parasite-schistosoma-mansoni-is-an-adpase-and-a-potent-inhibitor-of-platelet-aggregation
#12
Manal Elzoheiry, Akram A Da'dara, Armelle M deLaforcade, Samar N El-Beshbishi, Patrick J Skelly
Schistosomes are intravascular parasitic platyhelminthes infecting > 200 million people globally and causing a debilitating disease, schistosomiasis. Despite the relatively large size of the adult worms and their disruption of blood flow, surprisingly, they do not appear to provoke thrombus formation around them in vivo. We hypothesize that proteins expressed at the host-parasite interface are key to this ability. Here, we functionally express an ectonucleotide pyrophosphatase/phosphodiesterase homologue, SmNPP5, that is expressed at the tegumental surface of intravascular Schistosoma mansoni ...
April 18, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29649221/long-acting-insulin-analogues-for-type-1-diabetes-an-overview-of-systematic-reviews-and-meta-analysis-of-randomized-controlled-trials
#13
Fernanda O Laranjeira, Keitty R C de Andrade, Ana C M G Figueiredo, Everton N Silva, Mauricio G Pereira
BACKGROUND: The comparison between long acting insulin analogues (LAIA) and human insulin (NPH) has been investigated for decades, with many randomized controlled trials (RCTs) and systematic reviews giving mixed results. This overlapping and contradictory evidence has increased uncertainty on coverage decisions at health systems level. AIM: To conduct an overview of systematic reviews and update existing reviews, preparing new meta-analysis to determine whether LAIA are effective for T1D patients compared to NPH...
2018: PloS One
https://www.readbyqxmd.com/read/29617486/-structure-of-primary-healthcare-units-for-treating-persons-with-diabetes-cycles-i-and-ii-of-the-brazilian-national-program-to-improve-access-and-quality
#14
Rosália Garcia Neves, Suele Manjourany Silva Duro, Javier Muñiz, Teresa Rosalia Pérez Castro, Luiz Augusto Facchini, Elaine Tomasi
The objective was to describe the necessary structure for treating diabetes patients in the primary healthcare system, as evaluated in Cycles I and II of the Brazilian National Program for the Improvement of Access and Quality (PMAQ) in 2012 and 2014, according to the municipalities' characteristics. A descriptive study was used to assess primary care units whose teams participated in Cycles I and II of the PMAQ in 2012 and 2014. The study used variables from Module I of the external evaluation of the PMAQ that addresses the primary care units' structure...
March 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29617268/antidiabetic-and-renoprotective-effect-of-anogeissus-acuminata-leaf-extract-on-experimentally-induced-diabetic-nephropathy
#15
Archana M Navale, Archana Paranjape
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Hyperglycemia, oxidative stress, and inflammation are some of the mechanisms involved in renal damage. Anogeissus acuminata (AA) is used in India as an antidiabetic agent and has potent antioxidant activity. However, it has never been evaluated for its effect on diabetic nephropathy. Hence, in the present study we aimed to evaluate its effect on streptozotocin-induced diabetes mellitus and its renal complications...
April 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29575413/rising-synchrony-controls-western-north-american-ecosystems
#16
Bryan A Black, Peter van der Sleen, Emanuele Di Lorenzo, Daniel Griffin, William J Sydeman, Jason B Dunham, Ryan R Rykaczewski, Marisol García-Reyes, Mohammad Safeeq, Ivan Arismendi, Steven J Bograd
Along the western margin of North America, the winter expression of the North Pacific High (NPH) strongly influences interannual variability in coastal upwelling, storm track position, precipitation, and river discharge. Coherence among these factors induces covariance among physical and biological processes across adjacent marine and terrestrial ecosystems. Here, we show that over the past century the degree and spatial extent of this covariance (synchrony) has substantially increased, and is coincident with rising variance in the winter NPH...
March 25, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29541870/a-minimal-physiologically-based-pharmacokinetic-model-with-a-nested-endosome-compartment-for-novel-engineered-antibodies
#17
Dongfen Yuan, Frederik Rode, Yanguang Cao
We proposed here a minimal physiologically based pharmacokinetic (mPBPK) model for a group of novel engineered antibodies in mice and humans. These antibodies are designed with altered binding properties of their Fc domain with neonatal Fc receptor (FcRn) or the Fab domain with their cognate targets (recycling antibodies) in acidic endosomes. To enable simulations of such binding features in the change of antibody pharmacokinetics and its target suppression, we nested an endothelial endosome compartment in parallel with plasma compartment based on our previously established mPBPK model...
March 14, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29520439/validation-of-davson-s-equation-in-patients-suffering-from-idiopathic-normal-pressure-hydrocephalus
#18
Afroditi-Despina Lalou, Virginia Levrini, Matthew Garnett, Eva Nabbanja, Dong-Joo Kim, Laurent Gergele, Anna Bjornson, Zofia Czosnyka, Marek Czosnyka
INTRODUCTION: The so-called Davson's equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (If ) and sagittal sinus pressure (PSS ) There is a controversy over whether this fundamental equation is applicable in patients with normal pressure hydrocephalus (NPH). We investigated the relationship between Rout and ICP and also other compensatory, clinical and demographic parameters in NPH patients. METHOD: We carried out a retrospective study of 229 patients with primary NPH who had undergone constant-rate infusion studies in our hospital...
May 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29492569/significant-association-of-slow-vasogenic-icp-waves-with-normal-pressure-hydrocephalus-diagnosis
#19
Andreas Spiegelberg, Matthias Krause, Juergen Meixensberger, Burkhardt Seifert, Vartan Kurtcuoglu
OBJECTIVE: We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal. MATERIALS AND METHODS: We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492566/is-there-a-link-between-icp-derived-infusion-test-parameters-and-outcome-after-shunting-in-normal-pressure-hydrocephalus
#20
Eva Nabbanja, Marek Czosnyka, Nicole C Keong, Matthew Garnett, John D Pickard, Despina Afroditi Lalou, Zofia Czosnyka
OBJECTIVE: The term "hydrocephalus" encompasses a range of disorders characterised by clinical symptoms, abnormal brain imaging and derangement of cerebrospinal fluid (CSF) dynamics. The ability to elucidate which patients would benefit from CSF diversion (a shunt or third ventriculostomy) is often unclear. Similar difficulties are encountered in shunted patients to predict the scope for improvement by shunt re-adjustment or revision. MATERIALS AND METHODS: We compared retrospective pre-shunting infusion test results performed in 310 adult patients diagnosed with normal pressure hydrocephalus (NPH) and their improvement after shunting...
2018: Acta Neurochirurgica. Supplement
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