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https://www.readbyqxmd.com/read/28523482/an-rct-investigating-patient-driven-versus-physician-driven-titration-of-biasp-30-in-patients-with-type-2-diabetes-uncontrolled-using-nph-insulin
#1
Abdelmjid Chraibi, Shoorook Al-Herz, Bich Dao Nguyen, Djoko W Soeatmadji, Anil Shinde, Balasubramanian Lakshmivenkataraman, Samir H Assaad-Khalil
INTRODUCTION: The aim of this study was to confirm the efficacy of patient-driven titration of BIAsp 30 in terms of glycemic control, by comparing it to physician-driven titration of BIAsp 30, in patients with type 2 diabetes in North Africa, the Middle East, and Asia. METHODS: A 20-week, open-label, randomized, two-armed, parallel-group, multicenter study in Egypt, Indonesia, Morocco, Saudi Arabia, and Vietnam. Patients (n = 155) with type 2 diabetes inadequately controlled using neutral protamine Hagedorn (NPH) insulin were randomized to either patient-driven or physician-driven BIAsp 30 titration...
May 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28502690/the-clinical-effect-of-postoperative-hyperbaric-oxygen-therapy-on-idiopathic-normal-pressure-hydrocephalus-a-retrospective-and-comparative-analysis-of-61-patients-with-ventriculoperitoneal-shunt
#2
Lin Yang, Xingdong Wang, Yuping Li, Lang Chen, Zhengcun Yan, Lei She, Jun Dong
PURPOSE: The aim of the study was to examine the clinical effect of postoperative hyperbaric oxygen (HBO) therapy on symptoms and signs in the ventriculoperitoneal (VP) shunt insertion treatment of idiopathic normal pressure hydrocephalus (iNPH). MATERIALS AND METHODS: We conducted a retrospective analysis of 61 patients treated at our institution for iNPH since 2007. Patients were stratified into 2 groups according to undergoing pure VP shunt with gravitational valves (Group 1) or combined with postoperative HBO therapy (Group 2)...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28498794/diagnosis-of-normal-pressure-hydrocephalus-use-of-traditional-measures-in-the-era-of-volumetric-mr-imaging
#3
Nityanand Miskin, Hersh Patel, Ana M Franceschi, Benjamin Ades-Aron, Alexander Le, Brianna E Damadian, Christian Stanton, Yafell Serulle, James Golomb, Oded Gonen, Henry Rusinek, Ajax E George
Purpose To assess the diagnostic performance of the callosal angle (CA) and Evans index (EI) measures and to determine their role versus automated volumetric methods in clinical radiology. Materials and Methods Magnetic resonance (MR) examinations performed before surgery (within 1-5 months of the MR examination) in 36 shunt-responsive patients with normal-pressure hydrocephalus (NPH; mean age, 75 years; age range, 58-87 years; 26 men, 10 women) and MR examinations of age- and sex-matched patients with Alzheimer disease (n = 34) and healthy control volunteers (n = 36) were studied...
May 10, 2017: Radiology
https://www.readbyqxmd.com/read/28484522/cerebrospinal-fluid-dynamics-study-in-communicating-hydrocephalus
#4
Vengalathur Ganesan Ramesh, Vidhya Narasimhan, Chandramouli Balasubramanian
CONTEXT: Communicating hydrocephalus often poses a challenge in diagnosis and management decisions. AIMS: The objective of this study is to measure the opening pressure (Po), pressure volume index (PVI), and cerebrospinal fluid outflow resistance (Rout), in patients with communicating hydrocephalus using bolus lumbar injection method and to evaluate its diagnostic and prognostic value. MATERIALS AND METHODS: The study was conducted in 50 patients with communicating hydrocephalus, including normal pressure hydrocephalus (NPH) (19), post-meningitic hydrocephalus (23) and post-traumatic hydrocephalus (8)...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28482175/use-of-selenium-to-alleviate-naphthalene-induced-oxidative-stress-in-trifolium-repens-l
#5
Yingping Huang, Jueying Huang, Yizhi Song, Huigang Liu
Polycyclic aromatic hydrocarbons (PAHs) are among the most dangerous of environmental contaminants, due to their toxicity, carcinogenicity and mutagenicity. This study investigated the use of selenium (Se) to protect plants from the toxic effects of naphthalene (NPH). Exposing Trifolium repens L. (white clover) to a high concentration of NPH (soil spiked to 500mgkg(-1)) for 60 d significantly decreased biomass, CO2 assimilation rate (Pn), stomatal conductance (Gs) and intercellular CO2 concentration (Ci), while inducing production of H2O2 and malondialdehyde (MDA)...
May 5, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28466661/dose-unit-establishment-for-a-new-basal-insulin-using-joint-modeling-of-insulin-dose-and-glycemic-response
#6
Yongming Qu, Junxiang Luo, Parag Garhyan, Caryl J Antalis, Annette M Chang, Scott J Jacober
BACKGROUND: For new insulin analogs with properties that vary from human insulin, defining activity in units of human insulin based on glycemic lowering efficacy may be challenging. Here we present a new method that can be used to quantify a unit dose of an experimental insulin when the traditional euglycemic clamp method is not adequate. METHODS: Joint modeling of insulin dose and the glycemic outcome variable hemoglobin A1c (HbA1c), where both were response variables, was used to evaluate insulin unit potency for basal insulin peglispro (BIL)...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28460569/neurological-outcome-and-frequency-of-overdrainage-in-normal-pressure-hydrocephalus-directly-correlates-with-implanted-ventriculo-peritoneal-shunt-valve-type
#7
Yavor Bozhkov, Karl Roessler, Nirjhar Hore, Michael Buchfelder, Sebastian Brandner
BACKGROUND: The correlation between neurological outcome and frequency of overdrainage in the management of idiopathic normal pressure hydrocephalus (iNPH) using different ventriculoperitoneal shunt valve types is under investigation. Thus, we retrospectively compared one group of iNPH patients implanted with a programmable differential pressure valve (DPV) with another group treated by implantation of a DPV in combination with a flow-regulated anti-siphon device valve (ASD). METHODS: A retrospective evaluation of clinical outcome and frequency of overdrainage of 40 consecutive iNPH patients following surgical management between 08/2010 and 08/2014 was performed...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28421968/chronic-toxicology-studies-of-basal-insulin-peglispro-in-rats-and-dogs-a-novel-pegylated-insulin-lispro-analog-with-a-prolonged-duration-of-action
#8
Richard A Byrd, Jamie L Blackbourne, Mary Pat Knadler, Albert E Schultze, John L Vahle
Basal insulin peglispro (BIL) consists of insulin lispro with a 20-kDa polyethylene glycol (PEG) moiety covalently attached to lysine B28. Because chronic parenteral administration of PEGylated proteins to animals has sometimes resulted in PEG vacuolation of tissue macrophages, renal tubular cells, and choroid plexus ependymal cells, we investigated whether chronic subcutaneous (sc) injection of BIL in rats (52 weeks) and dogs (39 weeks) was associated with systemic toxicities or other changes, including vacuolation of tissue macrophages, renal tubular cells, and ependymal cells...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28421284/oropharyngeal-dysphagia-in-secondary-normal-pressure-hydrocephalus-due-to-corticobulbar-tract-compression-cases-series-and-review-of-literature
#9
Kwang Wook Jo, Youngkook Kim, Geun-Young Park, Ik Seong Park, Yongjun Jang, Sohn Dong Gyun, Sun Im
The association and mechanism involved in swallowing disturbance and normal pressure hydrocephalus (NPH) needs to be established. We report a case report where a patient who showed progressive swallowing dysfunction was diagnosed with secondary NPH. Tractography analysis showed corticobulbar tract compression by ventricular dilation. Drainage operation led to the recovery of tract volume with an improvement of swallowing function. We also report ten case series in which secondary NPH was associated with a swallowing disturbance...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28416566/structure-of-deah-rha-atpase-prp43p-bound-to-rna-implicates-a-pair-of-hairpins-and-motif-va-in-translocation-along-rna
#10
Yangzi He, Jonathan P Staley, Gregers Rom Andersen, Klaus H Nielsen
Three families of nucleic acid-dependent ATPases (DEAH/RHA, Ski2-like and NS3/NPH-II), termed the DExH ATPases, are thought to execute myriad functions by processive, ATP-dependent, 3' to 5' translocation along single-stranded nucleic acid. While the mechanism of translocation of the viral NS3/NPH-II family has been studied extensively, it has not been clear if or how the principles that have emerged for this family extend to the other two families. Here we report the crystal structure of the yeast DEAH/RHA family ATPase Prp43p, which functions in splicing and ribosome biogenesis, in complex with poly-uracil and a non-hydrolysable ATP analogue...
April 17, 2017: RNA
https://www.readbyqxmd.com/read/28394405/modeling-pharmacokinetic-profiles-of-insulin-regimens-to-enhance-understanding-of-subcutaneous-insulin-regimens
#11
Lai San Tham, Karen Schneck, Ali Ertekin, Jesus Reviriego
Insulin pharmacokinetics following subcutaneous administration were modeled, simulated, and displayed through an interactive and user-friendly interface to illustrate the time course of administered insulins frequently prescribed, providing a simple tool for clinicians through a straightforward visualization of insulin regimens. Pharmacokinetic data of insulin formulations with different onset and duration of action from several clinical studies, including insulin glargine, regular insulin, neutral protamine Hagedorn (NPH), insulin lispro, and premixed preparations of NPH with regular insulin (Mix 70/30), and insulin lispro protamine suspension with insulin lispro (Mix 50/50, Mix 75/25), were used to develop a predictive population pharmacokinetic model of insulins with consideration of factors such as insulin formulation, weight-based dosing, body-weight effect on volume of distribution, and administration time relative to meals, on the insulin time-action profile...
April 10, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28390870/insulin-not-glutamine-dipeptide-reduces-lipases-expression-and-prevents-fat-wasting-and-weight-loss-in-walker-256-tumor-bearing-rats
#12
Hely de Morais, Flaviane de Fatima Silva, Francemilson Goulart da Silva, Milene Ortiz Silva, Maria Fernanda Rodrigues Graciano, Maria Isabel Lovo Martins, Ângelo Rafael Carpinelli, Tânia Longo Mazucco, Roberto Barbosa Bazotte, Helenir Medri de Souza
Cachexia is the main cause of mortality in advanced cancer patients. We investigated the effects of insulin (INS) and glutamine dipeptide (GDP), isolated or associated, on cachexia and metabolic changes induced by Walker 256 tumor in rats. INS (NPH, 40 UI/kg, sc) or GDP (1.5g/kg, oral gavage) was once-daily administered during 11 days after tumor cell inoculation. GDP, INS or INS+GDP treatments did not influence the tumor growth. However, INS and INS+GDP prevented retroperitoneal fat wasting and body weight loss of tumor-bearing rats...
April 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28366602/clinical-outcomes-of-switching-from-insulin-glargine-to-nph-insulin-in-indigent-patients-at-a-charitable-pharmacy-the-charitable-insulin-nph-care-for-the-indigent-cinci-study
#13
Russell Curington, Mike Espel, Pamela C Heaton, Heidi Luder, Bethanne Brown
OBJECTIVES: To assess the clinical outcomes of indigent patients with type 2 diabetes served by a charitable pharmacy after therapy change from insulin glargine to NPH insulin. DESIGN: This was a 24-week prospective pilot study. SETTING: Community charitable pharmacy. PARTICIPANTS: Underserved, financially disadvantaged adults with type 2 diabetes. INTERVENTION: Conversion from insulin glargine to NPH insulin...
March 30, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28323508/nefopam-hydrochloride-loaded-microspheres-for-post-operative-pain-management-synthesis-physicochemical-characterization-and-in-vivo-evaluation
#14
Neelam Sharma, Sandeep Arora, Jitender Madan
Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management. Microspheres were synthesized using poly-3-hydroxybutyrate and poly-(ɛ-caprolactone) by double emulsion solvent evaporation technique. NPH-MS were characterized through FTIR, PXRD and SEM. In-vitro drug release study revealed sustained behavior till 24 h. Haemolysis was <5% which signified haemocompatibility of formulation. ED50 in rat tail-flick anti-nociceptive test was found ∼18...
March 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28314484/impact-of-health-policy-and-practice-on-finding-the-best-fit-for-patients-with-type-2-diabetes-after-metformin-failure-croatian-pilot-study
#15
Maja Cigrovski Berković, Davorka Herman Mahečić, Marina Gradišer, Ines Bilić-Ćurčić
AIM: We assessed the impact of clinical practice and health policy on the choice and efficacy of different second-line therapies for the treatment of type 2 diabetes (T2DM) after failure of metformin. METHODS: This retrospective database analysis included 200 patients with a follow-up period of 6 months. The primary end-point was achievement of HbA1c <7% and fasting (FBG) and postprandial glucose levels (PPG) <7.2mmol/L and <10mmol/L, respectively after three and six months of different add-on treatments...
June 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28302979/development-of-a-method-for-measuring-phytanic-acid-as-a-lifestyle-related-disease-biomarker-in-rat-serum-using-ultra-fast-liquid-chromatography-ultraviolet-spectrophotometry-combined-with-a-modified-2-nitrophenylhydrazine-derivatization-method
#16
Aoi Miyamoto, Takahiko Aoyama, Masahiro Okamura, Noboru Fukuda, Takahiro Ueno, Masanori Abe, Yoshiaki Matsumoto
A simple and rapid ultra-fast liquid chromatography-ultraviolet spectrophotometry (UFLC-UV) method combined with modified 2-nitrophenylhydrazine (2-NPH) derivatization was developed for determining phytanic acid (Phy) in rat serum. Serum Phy and heptadecanoic acid (the internal standard) were derivatized by 2-NPH at ambient temperature for 20 min and extracted in n-hexane. After extracting derivatized Phy (D-Phy) and derivatized IS from the reaction mixture, the extracts were separated with a YMC-Pack C8 column (150 × 3...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28302210/-risk-factors-for-neonatal-pulmonary-hemorrhage-in-the-neonatal-intensive-care-unit-of-a-municipal-hospital
#17
Jie Fan, Ming-Yan Hei, Xi-Lin Huang, Xiao-Ping Li
OBJECTIVE: To investigate the risk factors for neonatal pulmonary hemorrhage (NPH) in the neonatal intensive care unit (NICU) of a municipal hospital, and to provide a basis for the early identification and treatment of NPH. METHODS: A total of 112 neonates who were admitted to the NICU of Shaoyang Central Hospital of Hunan Province and diagnosed with NPH were enrolled as the case group. A nested case-control method was used to select, as a control group (n=224), the neonates who underwent the treatment with an assisted mechanical ventilator and did not experience pulmonary hemorrhage...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28277235/variation-in-the-level-of-detail-in-pediatric-voiding-cystourethrogram-reports
#18
Anthony J Schaeffer, Jeanne S Chow, Anastasia Ivanova, Gang Cui, Saul P Greenfield, J Michael Zerin, Alejandro Hoberman, Ranjiv I Mathews, Tej K Mattoo, Myra A Carpenter, Marva Moxey-Mims, Russell W Chesney, Caleb P Nelson
INTRODUCTION: Voiding cystourethrogram (VCUG) provides a wealth of data on urinary tract function and anatomy, but few standards exist for reporting VCUG findings. OBJECTIVE: We aimed to assess variability in VCUG reports and to test our hypothesis that VCUG reports from pediatric facilities and pediatric radiologists are more complete than those performed at other facilities or by non-pediatric radiologists. STUDY DESIGN: We analyzed original VCUG reports from children enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28261095/substrate-dependence-of-competitive-nucleotide-pyrophosphatase-phosphodiesterase1-npp1-inhibitors
#19
Sang-Yong Lee, Soumya Sarkar, Sanjay Bhattarai, Vigneshwaran Namasivayam, Steven De Jonghe, Holger Stephan, Piet Herdewijn, Ali El-Tayeb, Christa E Müller
Nucleotide pyrophosphatase/phosphodiesterase type 1 (NPP1) is a membrane glycoprotein involved in the hydrolysis of extracellular nucleotides. Its major substrate is ATP which is converted to AMP and diphosphate. NPP1 was proposed as a new therapeutic target in brain cancer and immuno-oncology. Several NPP1 inhibitors have been reported to date, most of which were evaluated vs. the artificial substrate p-nitrophenyl 5'-thymidine monophosphate (p-Nph-5'-TMP). Recently, we observed large discrepancies in inhibitory potencies for a class of competitive NPP1 inhibitors when tested vs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28239728/chemistry-of-cs2-and-scnph-adducts-of-the-pyramidal-phosphinidene-bridged-complex-mo2cp-%C3%AE-%C3%AE%C2%BA-1-%C3%AE%C2%BA-1-%C3%AE-5-pc5h4-co-2-%C3%AE-6-hmes-pme3
#20
Isabel G Albuerne, M Angeles Alvarez, M Esther García, Daniel García-Vivó, Miguel A Ruiz
The title complex reacted readily with CS2 and SCNPh to give the phosphinidene-cumulene adducts [Mo2Cp{μ-κ(1)P:κ(1)S,η(5)-P(CS2)C5H4}(CO)2(η(6)-HMes*)(PMe3)] and [Mo2Cp{μ-κ(1)P:κ(1)S,η(5)-P(C(NPh)S)C5H4}(CO)2(η(6)-HMes*)(PMe3)] respectively (Mes* = 2,4,6-C6H2(t)Bu3), as a result of the formal insertion of the C[double bond, length as m-dash]S bond of the heterocumulene into the metallocene Mo-P bond of the phosphinidene complex. The newly formed species bear a pyramidal P atom with a lone electron pair involved in fast inversion, and displayed strong nucleophilicity which enabled easy addition at the P site of carbon-based electrophiles and chalcogen atoms, while the uncoordinated S and N atoms were also competitive nucleophilic sites in these complexes...
March 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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