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JOURNAL ARTICLE
Jesús Troya, Guillermo Pousada, Rafael Micán, Carlos Galera, José Sanz, Ignacio de Los Santos, Carlos Dueñas, Noemí Cabello, Cristina Martín, María Josefa Galindo, María Ángeles Garcinuño, Roberto Pedrero-Tomé, Luis Buzón
BACKGROUND: Switching strategy with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) has become a gold standard for people living with HIV (PLWH), achieving high efficacy and safety rates. However, data regarding immune status in long-term real-life cohorts of pretreated patients are needed. METHODS: We performed a multicentre, non-controlled, retrospective study in virologically suppressed PLWH switching to B/F/TAF. We evaluated CD4+, CD8+ and CD4+/CD8+ ratio, efficacy and safety at weeks 48 and 96...
January 24, 2024: Journal of Antimicrobial Chemotherapy
#22
JOURNAL ARTICLE
Mary Ann Banerji, John B Buse, Naji Younes, Heidi Krause-Steinrauf, Adline Ghazi, Melissa Lee, Jean Park, Rodica Pop-Busui, Chantal Underkofler, Stephen P Fortmann
OBJECTIVE: We report mortality outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) among people with type 2 diabetes diagnosed within 10 years and no recent history of cardiovascular events or cancer. RESEARCH DESIGN AND METHODS: Overall mortality rates and major causes of death were assessed over an average of 5 years of follow-up. Cause of death was adjudicated centrally by a committee masked to treatment assignment...
April 1, 2024: Diabetes Care
#23
JOURNAL ARTICLE
Miyahra Haniko P Lopez, Sophie H Guenin, Jennifer Laborada, Mark G Lebwohl
Post-hyaluronic acid filler nodules are uncommon, unpredictable complications that present a challenge to clinical therapy. We report a case of a female in her fifties who developed edema and nodules 6 weeks after hyaluronic acid (HA) filler injection. After minimal improvement with oral steroids and intralesional hyaluronidase, a trial of oral abrocitinib was initiated, which yielded significant clinical improvement. Thus, abrocitinib may be a novel therapeutic option for delayed-onset nodules following injection of hyaluronic acid...
January 1, 2024: Journal of Drugs in Dermatology: JDD
#24
JOURNAL ARTICLE
Wenxiu Wang, Zhenhuang Zhuang, Zimin Song, Yimin Zhao, Tao Huang
BACKGROUND: Little is known about the role that combined sleep behaviors play in the association with chronic liver disease (CLD) risk. METHODS: We included 408,560 participants initially free of CLD from the UK Biobank. A healthy sleep pattern was defined by early chronotype, sleep duration of 7-8 h/day, no insomnia, no snoring, and no excessive daytime sleepiness. Cox regression models were used to examine the association of healthy sleep pattern with incident CLD and their interaction with PNPLA3 genetic risk...
January 8, 2024: Journal of Affective Disorders
#25
JOURNAL ARTICLE
Kun-Te Lin, Zih-Yang Lin, Cheng-Chieh Huang, Shang-Yan Yu, Jing-Lan Huang, Jian-Houng Lin, Yan-Ren Lin
INTRODUCTION: Focused assessment with sonography for trauma helps detect abdominal free fluid. Prehospital ultrasound scanning is also important because the early diagnosis of hemoperitoneum may reduce the time to definitive treatment in the hospital. This study investigated whether prehospital ultrasound scanning can help detect abdominal free fluid. MATERIALS AND METHODS: In this systematic review, relevant databases were searched for studies investigating prehospital ultrasound examinations for abdominal free fluid in trauma patients...
January 7, 2024: BMC Emergency Medicine
#26
JOURNAL ARTICLE
Tim Tippin, Shamia Faison, Virna Schuck, John Dunn, Odin Naderer
Smallpox was eradicated in 1980 but remains a biothreat due to the potential release of variola virus into the general population. Brincidofovir, the second medicine approved by the US Food and Drug Administration to treat smallpox, is metabolized by oxidative and hydrolytic pathways. The oxidative pathway is initiated by cytochrome P450 4F2 (CYP4F2), an enzyme lacking clinical probes for drug interaction studies. The aim of this work was to assess the impact of reduced activity CYP4F2 variants (rs2108622, C/T and T/T) on brincidofovir pharmacokinetics as a surrogate for drug inhibition...
January 3, 2024: Clinical Pharmacology in Drug Development
#27
REVIEW
Amanda Marselin, Lia Amalia, Lucia K Dinarti
OBJECTIVE: The clinical outcome and quality of life of CHD patients are greatly influenced by medication adherence. Non-adherence of CHD patients to treatment results in sub-optimal clinical outcomes and increasing costs. This study aims to describe effectiveness of the intervention to improve the medication adherence in CHD patients. METHODS: Systematic review methodology was used in this study. Scopus and PubMed were used to search the relevant article systematically...
2023: Journal of the Saudi Heart Association
#28
JOURNAL ARTICLE
Ting Zhang, Yinxiao Peng, Jun Li
OBJECTIVES: The study aimed to compare the efficacy and safety of percutaneous kyphoplasty (PKP) and vertebral body stenting (VBS) in the treatment of osteoporotic vertebral compression fractures (OVCFs) and evaluate the clinical efficacy, Cobb angle correction, and cement leakage associated with both methods for OVCFs. PATIENTS AND METHODS: A systematic search was conducted in PubMed, EMBASE, Cochrane Library, Medline, China National Knowledge, and Wanfang Data for clinical studies comparing VBS with PKP for OVCF up to May 2023...
January 1, 2024: Joint diseases and related surgery
#29
JOURNAL ARTICLE
Shraddha Patkar, Aditya Kunte, Vikram Chaudhari, Mahesh Goel
BACKGROUND: Up to 60% of incidentally detected gallbladder cancers (GBCs) have a primary stage of pathologic T2 stage (pT2), defined by invasion of the peri-adventitial tissue by the tumour, a plane breached during a simple cholecystectomy. This study assesses the impact of incidental detection of pT2 GBCs on survival outcomes. METHODS: Retrospective analysis of pT2 GBCs undergoing a curative resection was performed. Patients who received neoadjuvant chemotherapy before an upfront radical resection were excluded...
December 13, 2023: Journal of Surgical Oncology
#30
JOURNAL ARTICLE
Jiali Song, Anna Kosovicheva, Benjamin Wolfe
Driving requires vision, yet there is little empirical data about how vision and cognition support safe driving. It is difficult to study perception during natural driving because the experimental rigor required would be dangerous and unethical to implement on the road. The driving environment is complex, dynamic, and immensely variable, making it extremely challenging to accurately replicate in simulation. Our proposed solution is to study vision using stimuli which reflect this inherent complexity by using footage of real driving situations...
December 11, 2023: Behavior Research Methods
#31
JOURNAL ARTICLE
Valliappan Muthu, Ritesh Agarwal, Shivaprakash Mandya Rudramurthy, Deepak Thangaraju, Manoj Radhakishan Shevkani, Atul K Patel, Prakash Srinivas Shastri, Ashwini Tayade, Sudhir Bhandari, Vishwanath Gella, Jayanthi Savio, Surabhi Madan, Vinaykumar Hallur, Venkata Nagarjuna Maturu, Arjun Srinivasan, Nandini Sethuraman, Raminder Pal Singh Sibia, Sanjay Pujari, Ravindra Mehta, Tanu Singhal, Puneet Saxena, Varsha Gupta, Vasant Nagvekar, Parikshit Prayag, Dharmesh Patel, Immaculata Xess, Pratik Savaj, Inderpaul Singh Sehgal, Naresh Panda, Gayathri Devi Rajagopal, Riya Sandeep Parwani, Kamlesh Patel, Anuradha Deshmukh, Aruna Vyas, Raghava Rao Gandra, Srinivas Kishore Sistla, Priyadarshini A Padaki, Dharshni Ramar, Saurav Sarkar, Bharani Rachagulla, Pattabhiraman Vallandaramam, Krishna Prabha Premachandran, Sunil Pawar, Piyush Gugale, Pradeep Hosamani, Sunil Narayan Dutt, Satish Nair, Hariprasad Kalpakkam, Sanjiv Badhwar, Kiran Kumar Kompella, Nidhi Singla, Milind Navlakhe, Amrita Prayag, Gagandeep Singh, Poorvesh Dhakecha, Arunaloke Chakrabarti
OBJECTIVES: To compare COVID-19-associated pulmonary mucormycosis (CAPM) with COVID-19-associated rhino-orbital mucormycosis (CAROM), ascertain factors associated with CAPM among patients with COVID-19, and identify factors associated with 12-week mortality in CAPM. METHODS: We performed a retrospective multicenter cohort study. All study participants had COVID-19. We enrolled CAPM, CAROM, and COVID-19 subjects without mucormycosis (controls; age-matched). We collected information on demography, predisposing factors, and details of COVID-19 illness...
December 9, 2023: Clinical Microbiology and Infection
#32
JOURNAL ARTICLE
C P Prado, R F Cooke, A K Munhoz, S K Munhoz, M C G de Sousa, V M P da Silva, K G Pohler, J L M Vasconcelos
This experiment evaluated pregnancy losses from day 30 of gestation to calving in Bos indicus females, and evaluated if serum haptoglobin concentrations during early gestation impacts subsequent pregnancy losses. A total of 4926 Nelore females were used, being 1802 nulliparous heifers inseminated as yearlings (precocious heifers), 1356 nulliparous heifers inseminated at 24 months of age (conventional heifers), 887 suckling primiparous cows, and 881 suckling multiparous cows. Cows were assigned to an ovulation synchronization + fixed-time artificial insemination (FTAI) protocol from day -11 to 0 of the experiment...
November 17, 2023: Theriogenology
#33
JOURNAL ARTICLE
Naswandi Nur, Antonius Suwanto, Anja Meryandini, Maggy Thenawidjaja Suhartono, Esti Puspitasari, Hyung Kwoun Kim
BACKGROUND: Lipases have emerged as essential biocatalysts, having the ability to contribute to a wide range of industrial applications. Microbial lipases have garnered significant industrial attention due to their stability, selectivity, and broad substrate specificity. In the previous study, a unique lipolytic bacterium (Micrococcus luteus EMP48-D) was isolated from tempeh. It turns out the bacteria produce an acidic lipase, which is important in biodiesel production. Our main objectives were to clone the acidic lipase and investigate its potential in biodiesel production...
December 1, 2023: Journal, Genetic Engineering & Biotechnology
#34
JOURNAL ARTICLE
Melek Demir, Ahmet Çalışkan, İlknur Kaleli, Büşra Dönmez, Hatice Er, Çağrı Ergin
INTRODUCTION: In this study, we aimed to monitor anti-spike and anti-nucleocapsid antibodies positivity in healthcare workers (HCWs) vaccinated with two doses of inactivated CoronaVac® (Sinovac, China) vaccine. METHODS: Overall, 242 volunteer HCWs were included. Of the participants, 193 were HCWs without history of prior documented COVID-19 (Group 1), while 49 had history of prior documented COVID-19 before vaccination (Group 2). The participants were followed up for SARS-CoV-2 antibodies positivity at four different blood sampling time points (immediately before the second vaccine dose and at the 1st , 3rd months and 141-150 days after the second dose)...
December 2022: Germs
#35
JOURNAL ARTICLE
Lara D LaDage, Gail L McCormick, Travis R Robbins, Anna S Longwell, Tracy Langkilde
Stress experienced during ontogeny can have profound effects on the adult phenotype. However, stress can also be experienced intergenerationally, where an offspring's phenotype can be moulded by stress experienced by the parents. Although early-life and intergenerational stress can alter anatomy, physiology, and behaviour, nothing is known about how these stress contexts interact to affect the neural phenotype. Here, we examined how early-life and intergenerational stress affect the brain in eastern fence lizards ( Sceloporus undulatus )...
November 29, 2023: Proceedings. Biological Sciences
#36
JOURNAL ARTICLE
Sidra Hassan, Urayama Syun-Ichi, Saba Shabeer, Chien-Fu Wu, Hiromitsu Moriyama, Robert H A Coutts, Ioly Kotta-Loizou, Atif Jamal
Paeciliomyces variotii is a thermo-tolerant, ubiquitous fungus commonly found in food products, indoor environments, soil and clinical samples. It is a well-known biocontrol agent used against phytopathogenic fungi and its metabolites have many industrial applications. Rare reports of P. variotii- related human infections have been found in the medical literature. In this study, we report for the first time the infection of P. variotii isolated from a soil sample collected in a rice field with a double-stranded RNA virus, Paeciliomyces variotii partitivirus 1 (PvPV-1) in the family Partitiviridae...
November 2023: Journal of General Virology
#37
JOURNAL ARTICLE
Yi Stephanie Zhang, Abu T Taha, Isabel J B Thompson, Jeremy D Keenan, Daphne Yang, Joshua Wu, Jay M Stewart
PURPOSE: Epidemiologically, men have a higher incidence, severity, and progression of diabetic retinopathy (DR) than women. We investigated microvascular differences between men and women with diabetes on optical coherence tomography angiography (OCTA). METHODS: Three × 3 mm OCTA macula scans of non-diabetic and patients with diabetes were obtained. Vascular parameters included parafoveal vessel density (VD), vessel length density (VLD), and flow index (FI) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) as well as foveal avascular zone (FAZ) area and perimeter...
November 1, 2023: Translational Vision Science & Technology
#38
JOURNAL ARTICLE
Charlotte Ide-Walters, Claire Champ, Amy Hirst, Chris Jenkins, Vanessa Martinez, Charlene McShane
BACKGROUND: Cancer Research UK ran a mass-media campaign for 6 weeks from Sept 1, 2022, to Sept 13, 2022, targeted to people aged 50 years and older and from a lower social-grade (C2DE) in Northern Ireland. The campaign was developed to target barriers to help-seeking for the target audience. With this evaluation, we aimed to compare reported barriers and self-reported help-seeking before and after the campaign to assess changes potentially related to the campaign. METHODS: We ran cross-sectional surveys that collected data from independent participants before the campaign (wave 1; n=1262; July 18-Aug 31, 2022) and after the campaign (wave 2; n=1250; Oct 3-Nov 3, 2022; N=2512)...
November 2023: Lancet
#39
JOURNAL ARTICLE
Qian Yao, Jin Xu, Nan Tang, Weiji Chen, Quliang Gu, He Li
The soil environment for straw return is a rich and valuable library containing many microorganisms and proteins. In this study, we aimed to screen a high-quality β-glucosidase (BGL) from the soil metagenomic library and to overcome the limitation of the low extraction rate of resveratrol in Polygonum cuspidatum. This includes the construction of a soil metagenomic library, screening of BGL, bioinformatics analysis, cloning, expression, immobilization, enzymatic property analysis, and application for the transformation of polydatin...
November 21, 2023: Environmental Research
#40
JOURNAL ARTICLE
Pernell Tomasi, Hussein Abdel-Haleem
Brassica carinata has received considerable attention as a renewable biofuel crop for semi-arid zones due to its high oil content and polyunsaturated fatty acids contents. It is important to develop new drought-resistant cultivars of B. carinata production to expand its areas into more arid regions. The accumulation of leaf cuticular wax on plant surfaces is one mechanism that reduces non-stomatal water loss, thus increasing drought resistance in plants. To explore phenotypic variations in cuticular wax in B...
October 29, 2023: Plants (Basel, Switzerland)
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