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Manfei Si, Lin Jia, Kun Song, Qing Zhang, Beihua Kong
OBJECTIVE: Uterine sarcomas are rare, highly aggressive tumors with an unfavorable prognosis. The role of lymphadenectomy (LAD) remains controversial for this particular tumor type. To examine whether LAD can assist in prognosis or clinical benefits for uterine sarcoma patients, we performed a meta-analysis based on published studies. METHODS: We initially identified published studies by searching the PubMed database up to 30 November 2015. Study quality was evaluated systematically using the Newcastle-Ottawa Scale for assessing the quality of studies for inclusion in meta-analyses...
September 23, 2016: International Journal of Gynecological Cancer
Moses Okpeku, Ali Esmailizadeh, Adeniyi C Adeola, Liping Shu, Yesheng Zhang, Yangzi Wang, Timothy M Sanni, Ikhide G Imumorin, Sunday O Peters, Jiajin Zhang, Yang Dong, Wen Wang
The immune systems are fundamentally vital for evolution and survival of species; as such, selection patterns in innate immune loci are of special interest in molecular evolutionary research. The interferon regulatory factor (IRF) gene family control many different aspects of the innate and adaptive immune responses in vertebrates. Among these, IRF3 is known to take active part in very many biological processes. We assembled and evaluated 1356 base pairs of the IRF3 gene coding region in domesticated goats from Africa (Nigeria, Ethiopia and South Africa) and Asia (Iran and China) and the wild goat (Capra aegagrus)...
2016: PloS One
Lars Wallentin, Lars Lindhagen, Elisabet Ärnström, Steen Husted, Magnus Janzon, Søren Paaske Johnsen, Frederic Kontny, Tibor Kempf, Lars-Åke Levin, Bertil Lindahl, Mats Stridsberg, Elisabeth Ståhle, Per Venge, Kai C Wollert, Eva Swahn, Bo Lagerqvist
BACKGROUND: The FRISC-II trial was the first randomised trial to show a reduction in death or myocardial infarction with an early invasive versus a non-invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome. Here we provide a remaining lifetime perspective on the effects on all cardiovascular events during 15 years' follow-up. METHODS: The FRISC-II prospective, randomised, multicentre trial was done at 58 Scandinavian centres in Sweden, Denmark, and Norway...
October 15, 2016: Lancet
Jakob Manthey, Philippe Laramée, Steve Parrott, Jürgen Rehm
BACKGROUND: A considerable economic burden has been repeatedly associated with alcohol dependence (AD) - mostly calculated using aggregate data and alcohol-attributable fractions (top-down approach). However, this approach is limited by a number of assumptions, which are hard to test. Thus, cost estimates should ideally be validated with studies using individual data to estimate the same costs (bottom-up approach). However, bottom-up studies on the economic burden associated with AD are lacking...
2016: BMC Public Health
Seil Oh, Shinya Goto, Gabriele Accetta, Pantep Angchaisuksiri, A John Camm, Frank Cools, Sylvia Haas, Gloria Kayani, Yukihiro Koretsune, Toon Wei Lim, Frank Misselwitz, Martin van Eickels, Ajay K Kakkar
OBJECTIVE: To compare the distribution of international normalized ratios (INRs) in patients receiving vitamin K antagonist (VKA) for newly diagnosed atrial fibrillation in Eastern and Southeastern Asia and in other regions of the world (ORW) represented in the ongoing, global observational study GARFIELD-AF. METHODS AND RESULTS: 3621 and 13,541 patients were recruited prospectively in 2010-2013 from Asia and ORW, respectively. At baseline, excluding patients with unknown antithrombotic treatment, 1356 (37...
November 15, 2016: International Journal of Cardiology
Márta Patyi, Zsuzsanna Tóth, Edit Kelemen, Gyula Tálosi
INTRODUCTION: The extended beta-lactamase producing Enterobacteriaceae may cause asymptomatic carriage if present in the colon of premature infants or pregnant women. AIM: To assess the incidence of colonization among mothers whose infants were admitted to Neonatal Intensive Center on the day of their delivery for this pathogen. METHOD: From October 1, 2013 until October 31, 2015 the authors screened mothers on the day of their delivery for this pathogen...
August 2016: Orvosi Hetilap
Ann John, Chukwudi Okolie, Alison Porter, Chris Moore, Gareth Thomas, Richard Whitfield, Rossana Oretti, Helen Snooks
BACKGROUND: Non-accidental non-fatal poisoning (NANFP) is associated with high risk of repeat episodes and fatality. This cross-sectional study aims to describe the data sources and epidemiology of non-fatal poisonings (NFPs) presenting to the emergency ambulance service. METHODS: We assessed incidents of NFP across Wales from electronic ambulance call centre records and paper records completed by attending ambulance crews, December 2007 to February 2008. We descriptively analysed data completed by attending crews...
2016: BMJ Open
Matthew L Carlson, Nicole M Tombers, Colin L W Driscoll, Jamie J Van Gompel, John I Lane, Aditya Raghunathan, Kelly D Flemming, Michael J Link
OBJECTIVES: The frequency of intratumoral hemorrhage (ITH) in vestibular schwannoma (VS) remains undefined. METHODS: Retrospective case series of all patients diagnosed with hemorrhagic VS between 2003 and 2015 at a single tertiary academic skull base center. RESULTS: Five patients with ITH were evaluated, representing 0.4% of all newly diagnosed VS evaluated at the authors' center during this time. The median age at time of diagnosis was 66 years (range 39-83), four of five cases occurred in men, and all had sporadic unilateral tumors...
August 12, 2016: Laryngoscope
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S Lein
Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole-brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high-resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and 1,356 large-format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates...
November 1, 2016: Journal of Comparative Neurology
Ryan Martin, Gabrielle Giersch, Courtney Stosnider, Jacob D Ridings, Christopher J Womack, Trent A Hargens
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Teresa M Leyro, Erin E Crew, Susan W Bryson, Anna Lembke, Steffani R Bailey, Judith J Prochaska, Lisa Henriksen, Stephen P Fortmann, Joel D Killen, Diana T Killen, Sharon M Hall, Sean P David
OBJECTIVE: The goal of the current study was to empirically compare successive cohorts of treatment-seeking smokers who enrolled in randomised clinical trials in a region of the USA characterised by strong tobacco control policies and low smoking prevalence, over the past three decades. DESIGN: Retrospective treatment cohort comparison. SETTING: Data were collected from 9 randomised clinical trials conducted at Stanford University and the University of California, San Francisco, between 1990 and 2013...
2016: BMJ Open
Yuko Momose, Mari Maeda-Yamamoto, Hiroshi Nabetani
We conducted a systematic review of the literature for the ability of green tea epigallocatechin gallate (EGCG) to lower low-density lipoprotein cholesterol (LDL-C). Study subjects were limited to healthy individuals and randomized, controlled trials on human serum lipid levels, especially LDL-C, conducted. A total of 17 trials (n = 1356) met all of the inclusion criteria. According to weighted mean differences for changes from baseline with 95% confidence intervals (CI), 107-856 mg/d of EGCG for 4 to 14 weeks reduced LDL-C by -9...
September 2016: International Journal of Food Sciences and Nutrition
Brian J Nankivell, Chow H PʼNg, Philip J OʼConnell, Jeremy R Chapman
BACKGROUND: The contribution of calcineurin inhibitors (CNI) nephrotoxicity to progressive kidney transplant injury remains debated, with little long-term data from the modern tacrolimus (TAC) era using lower doses. METHODS: This longitudinal cohort study evaluated histological evidence of CNI nephrotoxicity from normal donor kidneys of successful kidney-pancreas transplant recipients during cyclosporine (CSA) and TAC eras, analyzed by intention-to-treat. RESULTS: From 200 patients, 1622 adequate prospective protocol (84...
August 2016: Transplantation
Fausto Petrelli, Serena Di Cosimo, Veronica Lonati, Sandro Barni
Metastatic breast cancer (MBC) is treated with cytotoxic drugs or endocrine agents according to the site and extent of the disease, biology, previous treatments, and the patient's condition, comorbidities, and wishes. In MBC, vinorelbine (VRB) and capecitabine (X; VRB + X) are chemotherapy drugs that hold activity as first or later lines of therapy. We conducted a systematic literature review and meta-analysis to quantify the efficacy of the VRB + X combination in HER2-negative (HER2(-)) MBC. We searched PubMed, EMBASE, SCOPUS, Web of Science, the Cochrane Library, and CINAHL for phase II/III clinical trials that assessed VRB + X for patients with HER2(-) MBC...
May 13, 2016: Clinical Breast Cancer
Cristina Gómez-Aix, Laura Pascual, Joaquín Cañizares, María Amelia Sánchez-Pina, Miguel A Aranda
BACKGROUND: Viruses are among the most destructive and difficult to control plant pathogens. Melon (Cucumis melo L.) has become the model species for the agriculturally important Cucurbitaceae family. Approaches that take advantage of recently developed genomic tools in melon have been extremely useful for understanding viral pathogenesis and can contribute to the identification of target genes for breeding new resistant cultivars. In this work, we have used a recently described melon microarray for transcriptome profiling of two melon cultivars infected with two strains of Melon necrotic spot virus (MNSV) that only differ on their 3'-untranslated regions...
2016: BMC Genomics
Irina Bancos, Shrikant Tamhane, Muhammad Shah, Danae A Delivanis, Fares Alahdab, Wiebke Arlt, Martin Fassnacht, M Hassan Murad
OBJECTIVE: To perform a systematic review of published literature on adrenal biopsy and to assess its performance in diagnosing adrenal malignancy. METHODS: Medline In-Process and Other Non-Indexed Citations, MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trial were searched from inception to February 2016. Reviewers extracted data and assessed methodological quality in duplicate. RESULTS: We included 32 observational studies reporting on 2174 patients (39...
August 2016: European Journal of Endocrinology
Xingxing Gu, Chuan-Jia Tong, Sarish Rehman, Li-Min Liu, Yanglong Hou, Shanqing Zhang
Low-cost, long-life, and high-performance lithium batteries not only provide an economically viable power source to electric vehicles and smart electricity grids but also address the issues of the energy shortage and environmental sustainability. Herein, low-cost, hierarchically porous, and nitrogen-doped loofah sponge carbon (N-LSC) derived from the loofah sponge has been synthesized via a simple calcining process and then applied as a multifunctional blocking layer for Li-S, Li-Se, and Li-I2 batteries. As a result of the ultrahigh specific area (2551...
June 29, 2016: ACS Applied Materials & Interfaces
Stephanie Matta, Elie Chammas, Chadi Alraies, Antoine Abchee, Wael AlJaroudi
BACKGROUND: Sedentary lifestyle has become prevalent in our community. Recent data showed controversy on the effect of regular exercise on left ventricular compliance and myocardial relaxation. HYPOTHESIS: We sought to assess whether physical inactivity is an independent predictor of diastolic dysfunction in or community, after adjustment for several covariates. METHODS: Consecutive outpatients presenting to the echocardiography laboratory between July 2013 and June 2014 were prospectively enrolled...
May 2016: Clinical Cardiology
Ki Jung Chang, Chang Hyung Hong, Si Heon Kim, Kang Soo Lee, Hyun Woong Roh, Dae Ryong Kang, Seong Hye Choi, Seong Yoon Kim, Duk L Na, Sang Won Seo, Do-Kwan Kim, Yunhwan Lee, Young Ki Chung, Ki Young Lim, Jai Sung Noh, Sang Joon Son
BACKGROUND: We compared the validity of models of subcortical ischemic depression (SID) and depression-executive dysfunction syndrome (DED) in predicting functional disability in the elderly. METHODS: We obtained data from elderly Korean subjects (n=1356) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A generalized estimating equation (GEE) model was constructed to measure functional disability using instrumental activity of daily living as a primary outcome...
September 2016: Archives of Gerontology and Geriatrics
Mary LeCloux, Peter Maramaldi, Kristie Thomas, Elizabeth Wharff
Developing policies and interventions that increase rates of mental health service use for suicidal adolescents is crucial for suicide prevention. Data from a sample of suicidal youth (n = 1356) from the National Longitudinal Study of Adolescent Health (Add Health) were analyzed to examine whether type of insurance, receipt of routine medical care, and access to school-based mental health treatment predicted mental health service use cross-sectionally and longitudinally. Rates of mental health service use were low in cross-sectional analyses at all three waves (∼11%-30%), despite the fact that respondents were at high risk for suicide attempts and depression...
May 4, 2016: Journal of Behavioral Health Services & Research
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