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https://www.readbyqxmd.com/read/29774388/withholding-or-withdrawing-of-life-sustaining-therapy-in-older-adults-%C3%A2-80-years-admitted-to-the-intensive-care-unit
#1
Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision)...
May 17, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29772608/activity-behaviours-in-lean-and-morbidly-obese-pregnant-women
#2
Caterina Fazzi, Nor Mohd-Shukri, Fiona C Denison, David H Saunders, Jane E Norman, Rebecca M Reynolds
Interventions to increase physical activity in pregnancy are challenging for morbidly obese women. Targeting sedentary behaviours may be a suitable alternative to increase energy expenditure. We aimed to determine total energy expenditure, and energy expended in sedentary activities in morbidly obese and lean pregnant women. We administered the Pregnancy Physical Activity Questionnaire PPAQ (non-objective) and the Actical accelerometer (objective) to morbidly obese (BMI≥40kg/m²) and lean (BMI≤25Kg/M²) pregnant women recruited in early (<24 weeks), and late (≥24 weeks) gestation...
May 17, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29749139/physical-inactivity-and-unhealthy-metabolic-status-are-associated-with-decreased-natural-killer-cell-activity
#3
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Jae Myun Lee, Tae Il Kim
PURPOSE: Several studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity according to physical activity and metabolic status. MATERIALS AND METHODS: A cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatory cytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29725498/characterization-of-portuguese-centenarian-eating-habits-nutritional-biomarkers-and-cardiovascular-risk-a-case-control-study
#4
A Pereira da Silva, A Valente, C Chaves, A Matos, A Gil, A C Santos, J P Gorjão-Clara, M Bicho
Background and Aims: Eating habits may contribute to longevity. We characterized the eating habits and cardiovascular risk (CVR) biomarkers in Portuguese centenarians (CENT) compared to controls. Methods and Results: Centenarians ( n = 253), 100.26 ± 1.98 years, were compared with 268 controls (67.51 ± 3.25), low (LCR) and high (HCR) CVR (QRISK®2-2016). Anthropometric and body composition were evaluated by bioimpedance. Abdominal obesity, BMI, and fat mass (FM) cut-offs were according to the WHO...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29677809/effect-of-ball-milling-on-electrochemical-properties-of-sulfur-polyacrylonitrile-span-cathode-in-li-s-battery
#5
Gyu-Bong Cho, Hea-Bin Park, Jae-Seung Jeong, Myung-Rang Chae, Yeon-Min Im, Lee Han-Gyeol, Park Sang-Hui, Ki-Won Kim
Ball-milling process was applied to increase sulfur content in sulfur/polyacrylonitrile (SPAN) composites and improve electrochemical properties of Li/S batteries. In contrast to as-received PAN, pre-heated PAN was pulverized by the ball-milling, resulting in the continuous size reduction with increasing the milling time. Sulfur contents in SPAN composites synthesized with a pre-heated and milled PAN were increased with prolonging the milling time and the maximum content reached 44.5% for the milling time of 10 h...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29648662/long-term-causes-of-death-in-patients-with-infective-endocarditis-who-undergo-medical-therapy-only-or-surgical-treatment-a-nationwide-population-based-study
#6
Lauge Østergaard, Louise Bruun Oestergaard, Trine Kiilerich Lauridsen, Anders Dahl, Mavish Chaudry, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun, Nana Valeur, Lars Køber, Emil Loldrup Fosbøl
OBJECTIVES: It is known that patients surviving infective endocarditis have a poor long-term prognosis; however, few studies have addressed the long-term causes of death in patients surviving the initial hospitalization. METHODS: Using Danish administrative registries, we identified patients admitted to a hospital with 1st time infective endocarditis in the period from January 1996 to December 2014, who were alive at the time of discharge. The study population was categorized into (i) patients undergoing medical therapy only and (ii) patients undergoing surgical and medical treatment...
April 10, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29626489/microrna-repertoire-and-comparative-analysis-of-andrias-davidianus-infected-with-ranavirus-using-deep-sequencing
#7
Yan Meng, Haifeng Tian, Qiaomu Hu, Hongwei Liang, Lingbing Zeng, Hanbing Xiao
Andrias davidianus is a large and economically important amphibian in China. Ranavirus infection causes serious losses in A. davidianus farming industry. MicroRNA mediated host-pathogen interactions are important in antiviral defense. In this study, five small-RNA libraries from ranavirus infected and non-infected A. davidianus spleens were sequenced using high throughput sequencing. The miRNA expression pattern, potential functions, and target genes were investigated. In total, 1356 known and 431 novel miRNAs were discovered...
April 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29604482/diagnostic-value-of-status-epilepticus-severity-score-for-survival-conditions-of-patients-with-status-epilepticus-a-prisma-compliant-systematic-review-and-meta-analysis
#8
Peipei Wang, Yong Guan, Xiaoyan Lin, Qiang Wang, Chun Fu, Xiaogang Wang, Shaoping Lv
OBJECTIVE: In recent years, the Status Epilepticus Severity Score (STESS) has been widely used to predict survival conditions of patients with status epilepticus (SE). However, the diagnostic value of STESS has not yet been evaluated. We therefore performed this meta-analysis to assess the overall diagnostic accuracy of STESS for predicting survival condition of patients with SE. METHODS: Systemic searches for relevant published studies were conducted in EMBASE, PubMed, Web of Science, and Cochrange databases up to July 2, 2017...
March 28, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29558557/behavioral-counseling-for-skin-cancer-prevention-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#9
REVIEW
Nora B Henrikson, Caitlin C Morrison, Paula R Blasi, Matt Nguyen, Kendall C Shibuya, Carrie D Patnode
Importance: Exposure to UV radiation, especially in childhood, increases skin cancer risk. Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for skin cancer prevention to inform the US Preventive Services Task Force (USPSTF). Data Sources: Cochrane Central Register of Controlled Trials, MEDLINE, and PubMed were searched for studies published from January 2009 to March 31, 2016, for skin cancer prevention and from August 2005 to March 31, 2016, for skin self-examination...
March 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29553262/assembly-of-multifold-helical-polyoxometalate-based-metal-organic-frameworks-as-anode-materials-in-lithium-ion-batteries
#10
Meng-Ting Li, Xi-Ya Yang, Ji-Sen Li, Ning Sheng, Guo-Dong Liu, Jing-Quan Sha, Ya-Qian Lan
For exploring the multifold helical fabrication of polyoxometalate (POM)-based hybrid compounds, four POM-based crystalline compounds with different meso-helices, H3 [Ag27 (trz)16 (H2 O)6 ][SiW12 O40 ]2 ·5H2 O (1), H[Ag27 (trz)16 (H2 O)4 ][PW12 O40 ]2 ·2H2 O (2), [Ag23 (trz)14 (H2 O)2 ][HSiW12 O40 ] (3), and [Ag23 (trz)14 (H2 O)2 ][PW12 O40 ] (4), were successfully isolated by using the delicate 1,2,3-triazole ligand and silver ions in this work. Crystal analysis reveals that compounds 1 and 2 and compounds 3 and 4 are isomorphous and display 2-/4-fold mixed meso-helices and simple 2-fold meso-helices, respectively...
April 2, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29547845/biodegradation-of-wastewater-in-alternating-aerobic-anoxic-lab-scale-pilot-plant-by-alcaligenes-sp-s-3-isolated-from-agricultural-field
#11
S R Geed, Sachin Prasad, M K Kureel, R S Singh, B N Rai
The isolated microbial Alcaligenes sp. S3 from the agricultural field was used for the biodegradation of synthetic wastewater containing atrazine. This study was conducted in an alternating aerobic-anoxic lab scale pilot plant. The performance of continuously operated pilot plant was evaluated in three different phases with varying atrazine concentration. The best performance of plant was observed in phase-II. The atrazine (200 mg/L) having COD value 1356 mg/L was used with varying flow rate and 90.56% COD removal was obtained at a flow rate of 300 mL/h on 122th day of operation...
March 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29527837/patterns-of-rpoc-mutations-in-drug-resistant-mycobacterium-tuberculosis-isolated-from-patients-in-south-korea
#12
Yeo Jun Yun, Jong Seok Lee, Je Chul Yoo, Eunjin Cho, Dahee Park, Yoon Hoh Kook, Keun Hwa Lee
BACKGROUND: Rifampicin (RFP) is one of the principal first-line drugs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory mutations have been identified in rpoC that restore the fitness of RFP-resistant M. tuberculosis strains with mutations in rpoB. To investigate rpoC mutation patterns, we analyzed 93 clinical M. tuberculosis isolates from patients in South Korea...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29512405/symptom-attribution-and-treatment-seeking-in-australian-veterans
#13
Breanna K Wright, Helen L Kelsall, David M Clarke, Alexander C McFarlane, Malcolm R Sim
To understand the role of symptom attribution in treatment-seeking behaviours, survey results of 1356 veterans (age = 38-72 years) were analysed. Controlling for symptom frequency, significant relationships were found for specialist and psychological-related consultations. Those who favoured psychological explanations for symptoms were more likely to attend specialist and psychology-related consultations and filled significantly more prescriptions than people who predominantly explained symptoms by situational factors (normalisers)...
March 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29441451/trauma-psychosocial-factors-and-help-seeking-in-three-immigrant-groups-in-finland
#14
Carla C Schubert, Raija-Leena Punamäki, Jaana Suvisaari, Päivikki Koponen, Anu Castaneda
Multiple psychosocial factors influence help-seeking behavior among immigrants, but studies have focused on separate issues in single cultural groups. This study tested a model of help-seeking behavior among three ethnically different immigrant groups. Participants were 1356 Somali, Russian, and Kurdish immigrants (18-64 years). They reported past traumatic events, social network, acculturation indices, trust in services, and mental health as well as usage of mental and somatic health services. Structural equation modeling (SEM) with multigroup procedure was applied...
February 13, 2018: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29343184/foot-strike-pattern-in-preschool-children-during-running-sex-and-shod-unshod-differences
#15
Pedro Á Latorre-Román, Juan A Párraga-Montilla, Ignacio Guardia-Monteagudo, Felipe García-Pinillos
PURPOSE: This study aims to determine the foot strike patterns (FSPs) and neutral support (no inversion [INV]/eversion [EVE] and no foot rotation) in preschool children, as well as to determine the influence of shod/unshod conditions and sex. METHODS: A total of 1356 children aged 3-6 years (673 boys and 683 girls) participated in this study. A sagittal and frontal-plane video (240 Hz) was recorded using a high-speed camcorder to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/ eversion (INV/EVE) and foot rotation on initial contact...
January 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29318985/a-randomised-controlled-trial-and-economic-evaluation-of-intraoperative-cell-salvage-during-caesarean-section-in-women-at-risk-of-haemorrhage-the-salvo-cell-salvage-in-obstetrics-trial
#16
Khalid S Khan, Philip Moore, Matthew Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Tracy Roberts, Carol McLoughlin, Lee Beresford, James Geoghegan, Jane Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Louise Jackson, Doris Lanz, Julie Dodds
BACKGROUND: Caesarean section is associated with blood loss and maternal morbidity. Excessive blood loss requires transfusion of donor (allogeneic) blood, which is a finite resource. Cell salvage returns blood lost during surgery to the mother. It may avoid the need for donor blood transfusion, but reliable evidence of its effects is lacking. OBJECTIVES: To determine if routine use of cell salvage during caesarean section in mothers at risk of haemorrhage reduces the rates of blood transfusion and postpartum maternal morbidity, and is cost-effective, in comparison with standard practice without routine salvage use...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29299974/do-pregnant-women-want-to-know-the-sex-of-the-expected-child-at-routine-ultrasound-and-are-they-interested-in-sex-selection
#17
Margareta Larsson, Minna Berglund, Emelie Jarl, Tanja Tydén
BACKGROUND: The aim of the study was to investigate if expecting parents wanted to know the sex of the fetus during ultrasound examination and if they had discussed it with the midwife. Another aim was to explore any interest in sex selection. METHODS: A longitudinal survey in early and late pregnancy among 2393 women in Sweden. RESULTS: Almost all (95.8%, n = 2289) women had discussed sex determination with the partner before the ultrasound scan, and 57% (n = 1356) of women and their partners wanted to find out the fetal sex...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29296770/osteonecrosis-of-the-femoral-head-in-sickle-cell-disease-prevalence-comorbidities-and-surgical-outcomes-in-california
#18
Oyebimpe Adesina, Ann Brunson, Theresa H M Keegan, Ted Wun
Osteonecrosis of the femoral head (ONFH) is a prevalent complication of sickle cell disease (SCD) that has not been well described in population-based cohort studies. Using California's Office of Statewide Planning and Development discharge databases (1991-2013), we estimated the cumulative incidence of ONFH after accounting for the competing risk of death and used a multivariable Cox proportional hazards regression to identify factors associated with ONFH diagnosis. We also calculated rates of readmissions to the hospital or emergency department within 30 to 90 days of hip replacement surgery...
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29258236/lc-ms-ms-detection-of-karlotoxins-reveals-new-variants-in-strains-of-the-marine-dinoflagellate-karlodinium-veneficum-from-the-ebro-delta-nw-mediterranean
#19
Bernd Krock, Julia A Busch, Urban Tillmann, Francisco García-Camacho, Asterio Sánchez-Mirón, Juan J Gallardo-Rodríguez, Lorenzo López-Rosales, Karl B Andree, Margarita Fernández-Tejedor, Matthias Witt, Allan D Cembella, Allen R Place
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the detection and quantitation of karlotoxins in the selected reaction monitoring (SRM) mode. This novel method was based upon the analysis of purified karlotoxins (KcTx-1, KmTx-2, 44-oxo-KmTx-2, KmTx-5), one amphidinol (AM-18), and unpurified extracts of bulk cultures of the marine dinoflagellate Karlodinium veneficum strain CCMP2936 from Delaware (Eastern USA), which produces KmTx-1 and KmTx-3. The limit of detection of the SRM method for KmTx-2 was determined as 2...
December 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29233111/effectiveness-of-two-community-based-strategies-on-disease-knowledge-and-health-behaviour-regarding-malaria-diarrhoea-and-pneumonia-in-ghana
#20
Blanca Escribano-Ferrer, Margaret Gyapong, Jane Bruce, Solomon A Narh Bana, Clement T Narh, Naa-Korkor Allotey, Roland Glover, Charity Azantilow, Constance Bart-Plange, Isabella Sagoe-Moses, Jayne Webster
BACKGROUND: Ghana has developed two community-based strategies that aim to increase access to quality treatment for malaria, diarrhoea and suspected pneumonia, and to improve household and family practices: integrated Community Case Management (iCCM) and Community-based Health Planning and Services (CHPS). The objective of the study was to assess the effectiveness of iCCM and CHPS on disease knowledge and health behaviour regarding malaria, diarrhoea and pneumonia. METHODS: A household survey was conducted two and eight years after implementation of iCCM in the Volta and Northern Regions of Ghana respectively, and more than ten years of CHPS implementation in both regions...
December 12, 2017: BMC Public Health
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