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https://www.readbyqxmd.com/read/29055278/enhanced-sensitivity-to-detection-nanomolar-level-of-cu-2-compared-to-spectrophotometry-method-by-functionalized-gold-nanoparticles-design-of-sensor-assisted-by-exploiting-first-order-data-with-chemometrics
#1
Zolaikha Rasouli, Raouf Ghavami
A simple, sensitive and efficient colorimetric assay platform for the determination of Cu(2+) was proposed with the aim of developing sensitive detection based on the aggregation of AuNPs in presence of a histamine H2-receptor antagonist (famotidine, FAM) as recognition site. This study is the first to demonstrate that the molar extinction coefficients of the complexes formed by FAM and Cu(2+) are very low (by analyzing the chemometrics methods on the first order data arising from different metal to ligand ratio method), leading to the undesirable sensitivity of FAM-based assays...
October 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055267/nature-differences-of-fulvic-acid-fractions-induced-by-extracted-sequence-as-explanatory-factors-for-binding-characteristics-of-cu-2
#2
Zhenrui Zhang, Changwei Lü, Jiang He, Manshu Gao, Boyi Zhao, Bin Zhou, Jing Guo, Haijun Zhou, Xiaoting Liu, Zhuoming Li, Wenjing Shi, Yongjie Jiao, Wenxi Zhao, Yu Zhang
The isolation of fulvic acid (FA) fractions with relatively homogeneity is a key to reveal the binding mechanisms between FA and heavy metals. In this work, nine FA fractions were obtained using sequential alkali extraction procedure and nature differences of the extracted FA fractions were considered as explanatory factors for binding characteristics of Cu(2+). The results indicate that the contents of carboxyl and phenolic groups decrease with increasing extractions along with an opposite trend for the content of nitrogen-containing groups...
October 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29055224/primary-suction-thrombectomy-for-acute-ischemic-stroke-a-meta-analysis-of-the-current-literature
#3
Jin Pyeong Jeon, Sung-Eun Kim, Chul Ho Kim
OBJECTIVES: We conducted a meta-analysis to assess the angiographic and clinical outcomes for ischemic stroke patients treated with primary suction thrombectomy and to compare the procedural outcomes based on the treatment strategies (primary suction vs. stent retriever thrombectomy). PATIENTS AND METHODS: We conducted a systemic literature review through an online data base from January 2004 through December 2016. The primary outcomes were rate of successful recanalization on final angiogram and good outcome three months after stroke onset...
October 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055163/microbial-sensor-for-drug-susceptibility-testing-of-mycobacterium-tuberculosis
#4
Zhi-Tao Zhang, Dian-Bing Wang, Chuan-You Li, Jiao-Yu Deng, Ji-Bin Zhang, Li-Jun Bi, Xian-En Zhang
AIMS: Drug susceptibility testing (DST) of clinical isolates of Mycobacterium tuberculosis (M. tuberculosis) is critical in treating tuberculosis. We demonstrate the possibility of using a microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST. METHODS AND RESULTS: The sensor is made of an oxygen electrode with M. tuberculosis cells attached to its surface. This sensor monitors the residual oxygen consumption of M. tuberculosis cells after treatment with anti-TB drugs with glycerine as a carbon source...
October 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29055128/a-generalized-outflow-boundary-condition-impedance-model-for-non-invasive-prediction-of-ischemia-in-diseased-coronary-arteries
#5
Iyad A Fayssal, Fadl Moukalled, Samir Alam, Hussain Isma'eel
This paper reports on a new boundary condition formulation to model the total coronary myocardial flow and impedance characteristics of the myocardial vascular bed for any specific patient when considered for non-invasive diagnosis of fractional flow reserve (FFR). The developed boundary condition model inherits an implicit representation of the downstream truncated vascular bed and is based on integrating patient-specific physiologic parameters that can be non-invasively extracted for each patient to account for blood flow demand to the myocardium at rest and hyperemic conditions...
October 21, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29055096/an-improved-method-for-bivariate-meta-analysis-when-within-study-correlations-are-unknown
#6
Chuan Hong, Richard D Riley, Yong Chen
Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the dependence between multiple estimates from the same study. However, standard inference procedures for multivariate meta-analysis require the knowledge of within-study correlations, which are usually unavailable. This limits standard inference approaches in practice...
October 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29055054/a-multicenter-prospective-evaluation-study-of-endoscopic-ultrasound-guided-hepaticogastrostomy-combined-with-antegrade-stenting-with-video
#7
Takeshi Ogura, Masayuki Kitano, Mamoru Takenaka, Atsushi Okuda, Kosuke Minaga, Kentaro Yamao, Yukitaka Yamashita, Keiichi Hatamaru, Chishio Noguchi, Yasuhiko Gotoh, Taira Kuroda, Tomoyuki Yokota, Hidefumi Nishikiori, Ryota Sagami, Kazuhide Higuchi, Yasutaka Chiba
OBJECTIVE: EUS-guided hepaticogastrostomy (EUS-HGS) is often indicated for advanced stage patients because it prevents the adverse events associated with EUS-HGS procedures, and provides long stent patency. EUS-guided antegrade stenting (AS) has been developed as an advanced technique. Thus, to prevent adverse events and achieve, long stent patency, EUS-AS combined with EUS-HGS (EUS-HGAS) has been reported. The aim of this study was to evaluate the technical feasibility and efficacy of EUS-HGAS in a multicenter, prospective study...
October 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29054955/trapped-ipsilateral-lateral-ventricle-a-delayed-complication-of-hemispherotomy-for-rasmussen-s-encephalitis
#8
Rajesh Shankar Iyer, Ravi Mohan Rao, Karunakaran Muthukalathi, Praveen Kumar
Hemispherotomy is the currently preferred surgical treatment option for refractory unihemispheric epilepsies. The incidence of hydrocephalus is greatly reduced in this disconnective procedure when compared with the resective procedure of anatomical hemispherectomy. We describe the occurrence of ipsilateral trapped lateral ventricle months after hemispherotomy for Rasmussen's encephalitis. There is enough evidence to suggest that this rare and interesting complication is due to the local inflammatory changes associated with the surgical trauma...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054951/community-acquired-pseudomonas-aeruginosa-meningitis
#9
Charles Gallaher, James Norman, Abhinav Singh, Frances Sanderson
Gram-negative bacilli such as Pseudomonas aeruginosa are a rare cause of meningitis. Patients developing P. aeruginosa meningitis most commonly have a history of neurosurgical procedures. We report a patient who presented with community-acquired chronic meningitis secondary to P. aeruginosa, related to surgery for otosclerosis 5 years previously.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054946/management-challenges-of-late-presentation-dacron-patch-infection-after-carotid-endarterectomy
#10
Jie Hua Xu, Nishath Altaf, Patrik Tosenovsky, Bibombe Patrice Mwipatayi
An 83-year-old man presented 4 years after right carotid endarterectomy (CEA) with an infection of his prosthetic Dacron patch. Initial scans (CT angiogram and whole body labelled white cell scan) were clear with no infection or collection noted. Systemically, the patient presented well with no recorded fevers. With an occluded left internal carotid artery and severely stenosed vertebral arteries, surgery presented a high risk of major stroke due to the lack collateral supply and this was discussed extensively...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054935/familial-history-aggregation-on-acute-appendicitis
#11
Francesc Simó Alari, Israel Gutierrez, Judit Gimenéz Pérez
Appendectomy is the most commonly performed surgical procedure, affecting 1%-8% of the paediatric population, with a total 7% lifetime risk, most likely in adolescents and young adults.A case of familial aggregation was reported in our hospital in a family composed of nine siblings from which six of them (66.6%) had been treated of acute appendicitis, five of them in our centre.Many factors have been described as predisposing to appendicitis. Several studies have highlighted the influence of genes in the evolution of this disease and its severity, demonstrating a relative risk increase by three when family history is present...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054934/radiation-induced-dna-damage-in-operators-performing-endovascular-aortic-repair
#12
Tamer El-Sayed, Ashish S Patel, Jun S Cho, James A Kelly, Francesca E Ludwinski, Prakash Saha, Oliver T Lyons, Alberto Smith, Bijan Modarai
Background -Radiation exposure during fluoroscopically-guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to measure DNA damage/repair markers in operators perfoming EVAR. Methods -Expression of the DNA damage/repair marker, gamma-H2AX (γ-H2AX) and DNA damage response (DDR) marker, phosphorylated ataxia telangiectasia mutated (pATM), were quantified in circulating lymphocytes in operators during the peri-operative period of endovascular (infra-renal [IEVAR], branched [BEVAR] and fenestrated [FEVAR]) and open aortic repair using flow cytometry...
October 20, 2017: Circulation
https://www.readbyqxmd.com/read/29054914/flow-diversion-for-the-treatment-of-posterior-inferior-cerebellar-artery-aneurysms-a-novel-classification-and-strategies
#13
Visish M Srinivasan, Michael George Zaki Ghali, Oleg E Reznik, Jacob Cherian, Maxim Mokin, Travis M Dumont, John R Gaughen, Ramesh Grandhi, Ajit S Puri, Stephen R Chen, Jeremiah N Johnson, Peter Kan
BACKGROUND: The pipeline embolization device (PED) is frequently used in the treatment of anterior circulation aneurysms, especially around the carotid siphon, with generally excellent results. However, treatment of posterior inferior cerebellar artery (PICA) aneurysms with flow diversion (FD) has not been specifically described or discussed. While there are reports of treating PICA aneurysms using placement of FD stents in the vertebral artery, there are no reports of treating these lesions by placement of flow diverting stents in the PICA vessel itself...
October 20, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29054842/acute-biventricular-mechanical-circulatory-support-for-cardiogenic-shock
#14
Sudeep Kuchibhotla, Michele L Esposito, Catalina Breton, Robert Pedicini, Andrew Mullin, Ryan O'Kelly, Mark Anderson, Dennis L Morris, George Batsides, Danny Ramzy, Mark Grise, Duc Thinh Pham, Navin K Kapur
BACKGROUND: Biventricular failure is associated with high in-hospital mortality. Limited data regarding the efficacy of biventricular Impella axial flow catheters (BiPella) support for biventricular failure exist. The aim of this study was to explore the clinical utility of percutaneously delivered BiPella as a novel acute mechanical support strategy for patients with cardiogenic shock complicated by biventricular failure. METHODS AND RESULTS: We retrospectively analyzed data from 20 patients receiving BiPella for biventricular failure from 5 tertiary-care hospitals in the United States...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054799/systematic-evaluation-of-cell-selex-enriched-aptamers-binding-to-breast-cancer-cells
#15
Laia Civit, Seyed Mohammad Taghdisi, Anna Jonczyk, Silvana Haßel, Carsten Gröber, Michael Blank, H James Stunden, Marc Beyer, Joachim Schultze, Eicke Latz, Günter Mayer
The sensitive and specific detection of pathogenic cells is essential in clinical diagnostics. To achieve this, molecular tools are required that unequivocally recognise appropriate cell surface molecules, such as biomarkers that come along with disease onset and progression. Aptamers are short single-stranded oligonucleotides that interact with cognate target molecules with high affinity and specificity. Within the last years they have gained an increased attention as cell-recognition tools. Here, we report a systematic analysis of a cell-SELEX procedure, for the identification of aptamers that recognise breast cancer cells...
October 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29054795/topical-ala-pdt-as-alternative-therapeutic-option-in-treatment-recalcitrant-dermatosis-report-of-4-cases
#16
REVIEW
Calvina Theresia, Jie Zheng, Xiao-Ying Chen
BACKGROUND: Topical Photodynamic therapy (PDT) is widely acknowledged for its safety and effectiveness in treating oncologic skin diseases such as basal cell carcinoma, actinic keratosis and squamous cell carcinoma in situ. Despite its broad applications in dermatology, this method is a relatively new therapeutic option for treating inflammatory/infectious skin diseases. OBJECTIVES: To determine whether topical PDT is a safe and effective treatment option in treating treatment-recalcitrant dermatosis...
October 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29054777/hidden-blood-loss-in-anterior-cervical-fusion-surgery-an-analysis-of-risk-factors
#17
Longfei Wen, Daxiang Jin, Weixing Xie, Yue Li, Weijian Chen, Shuncong Zhang, Xiaobing Jiang
STUDY DESIGN: a retrospective study. OBJECTIVES: Anterior cervical fusion surgery is widely used procedure in cervical spondylosis. When considering the blood re-infusion strategies of cervical fusion surgery, the amount of blood loss is one of the key element. We usually calculate the blood loss according to the surgical bleeding plus the postoperative drainage; however, it ignored the possibility that there may be a partly amount of hidden blood loss. METHODS: We performed a retrospective study to determine the risk factors for HBL in patients underwent anterior cervical fusion surgery for degenerative spine from 2013 to 2016...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054770/challenges-in-rendering-coral-triangle-habitat-richness-in-remotely-sensed-habitat-maps-the-case-of-bunaken-island-indonesia
#18
Eghbert Elvan Ampou, Sylvain Ouillon, Serge Andréfouët
The Coral Triangle is the epicenter of marine biodiversity, yet the numbers of habitats that can be found on coral reefs remain poorly described. First surveys for habitat mapping in Indonesia revealed a high number of habitats (>150) even for structurally simple reefs. To be able to represent all these habitats, typical habitat mapping procedures and performances are poorly effective even using very high resolution satellite images. Using Bunaken Island (North Sulawesi, Indonesia) as a case study, we devised a way to maintain all the in situ habitat information in remote sensing habitat map products without loss and with mapping procedures based on photo-interpretation...
October 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29054726/a-comparison-of-walking-gait-following-mechanical-and-kinematic-alignment-in-total-knee-joint-replacement
#19
Peter J McNair, Mark G Boocock, Nicholas D Dominick, Richard J Kelly, Bill J Farrington, Simon W Young
BACKGROUND: Although previous studies have compared radiological, pain, and function scores in kinematically aligned (KA) and mechanically aligned (MA) total knee arthroplasty (TKA), no previous studies have undertaken a three-dimensional (3D) gait analysis in these groups. This study compared kinematic and kinetic variables recorded during level walking in patients at least 2 years post-surgery who underwent an MA or KA procedure. METHODS: Utilizing a 9-camera motion analysis system, gait analysis was undertaken on 29 patients (MA = 15, KA = 14)...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29054720/a-randomized-comparison-of-two-robotic-virtual-reality-simulators-and-evaluation-of-trainees-skills-transfer-to-a-simulated-robotic-urethrovesical-anastomosis-task
#20
Jen Hoogenes, Nathan Wong, Badr Al-Harbi, Kevin S Kim, Saahil Vij, Elisa Bolognone, Mackenzie Quantz, Yanbo Guo, Bobby Shayegan, Edward D Matsumoto
OBJECTIVE: To determine, via a randomized comparison study, whether robotic simulator-acquired skills transfer to performance of a urethrovesical anastomosis (UVA) on a 3D-printed bladder model using the da Vinci Robot. MATERIALS AND METHODS: Medical students, surgical residents, and fellows were recruited and divided into two groups: G1 (junior trainees) and G2 (senior trainees). Participants were randomized to identical simulator training curricula on the dV-Trainer (dV-T) or da Vinci Surgical Skills Simulator (dVSSS)...
October 17, 2017: Urology
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