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https://www.readbyqxmd.com/read/29458225/-indication-quality-concepts-and-ethical-implications
#1
Andrea Dörries
BACKGROUND: In recent times - also due to new laws - a good "indication quality" has been called for. The aim of this paper is to contribute to the debate about "indication quality" by looking into the meaning of the term "indication" as well as the meaning of an adequate understanding of quality. METHODS: Initially, a conceptual analysis is made of how indication is an integral part of the therapeutic decision-making process between physician and patient, in which, next to evidence-based elements, also normative elements are included (step 1)...
February 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29458216/institution-of-a-comprehensive-postpartum-hemorrhage-bundle-at-a-large-academic-center-does-not-immediately-reduce-maternal-morbidity
#2
Rebecca Feldman Hamm, Eileen Wang, Kathleen O'Rourke, April Romanos, Sindhu K Srinivas
OBJECTIVE: Obstetric hemorrhage is a leading cause of morbidity and mortality. We sought to assess whether institution of a postpartum hemorrhage (PPH) bundle could improve maternal morbidity in our population. STUDY DESIGN: Preintervention data (PRE) was collected on all deliveries at Hospital of the University of Pennsylvania between October 15, 2013 and December 15, 2013. A two-pronged, multidisciplinary educational and procedural intervention related to PPH was instituted from March 2015 to June 2015...
February 19, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29458201/computer-assisted-surgery-in-acetabular-fractures-virtual-reduction-of-acetabular-fracture-using-the-first-patient-specific-biomechanical-model-simulator
#3
M Boudissa, H Oliveri, M Chabanas, J Tonetti
Preoperative planning for the management of acetabular fracture is founded on geometric models allowing virtual repositioning of the bone fragments, but not taking account of soft tissue and the realities of the surgical procedure. The present technical note reports results using the first simulator to be based on a patient-specific biomechanical model, simulating the action of forces on the fragments and also the interactions between soft issue and bone: muscles, capsules, ligaments, and bone contacts. In all 14 cases, biomechanical simulation faithfully reproduced the intraoperative behavior of the various bone fragments and reduction quality...
February 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29458195/human-dorsal-root-ganglion-pulsed-radiofrequency-treatment-modulates-cerebrospinal-fluid-lymphocytes-and-neuroinflammatory-markers-in-chronic-radicular-pain
#4
Basabjit Das, Melissa Conroy, David Moore, Joanne Lysaght, Connail McCrory
Radicular pain is a common cause of disability. Traditionally treatment has been either epidural steroid injection providing short-term relief or surgery with associated complications. Pulsed radiofrequency (PRF) applied to the Dorsal Root Ganglion (DRG) is a minimally invasive day-care treatment, which is gaining significant clinical acceptance in a selective group of patients with pure radicular pain. Greater insights into the immunomodulatory effects of this procedure may help to further optimise its application and find alternative treatment options...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458194/differential-effects-of-acute-versus-chronic-stress-on-ethanol-sensitivity-evidence-for-interactions-on-both-behavioral-and-neuroimmune-outcomes
#5
Tamara L Doremus-Fitzwater, Jacqueline E Paniccia, Anny Gano, Andrew Vore, Terrence Deak
Acute alcohol intoxication induces significant alterations in brain cytokines. Since stress challenges also profoundly impact central cytokine expression, these experiments examined the influence of acute and chronic stress on ethanol-induced brain cytokine responses. In Experiment 1, adult male rats were exposed to acute footshock. After a post-stress recovery interval of 0, 2, 4, or 24 h, rats were administered ethanol (4 g/kg; intragastric), with trunk blood and brains collected 3 h later. In non-stressed controls, acute ethanol increased expression of Il-6 and IκBα in the hippocampus...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458161/multiple-mycotoxin-analysis-in-nut-products-occurrence-and-risk-characterization
#6
Sara C Cunha, S Sá, José O Fernandes
Nuts consumption plays an important role in Mediterranean diet, being a good source of proteins, vitamins, minerals and unsaturated fatty acids. However, nuts can be also a source of harmful mycotoxins with negative impact on human health. In this work, the occurrence of 16 mycotoxins belonging to different chemical classes, was assessed in several nut products. The analytical method used was based on modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) procedure followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458153/eus-guided-transluminal-interventions
#7
Uzma D Siddiqui, Michael J Levy
The role of endoscopic ultrasound (EUS) has transitioned from a diagnostic to a therapeutic one over the past 40 years. With the advent of curvilinear array echoendoscopes in the 1990's with an accessory channel, multiple tools and devices have been developed and utilized for a variety of transluminal interventions. EUS provides a viable option and is becoming the procedure of choice for many interventions including bile and pancreatic duct drainage, guiding angiotherapy, pancreatic fluid collection management, gallbladder drainage, and creating a gastrojejunostomy...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29458136/changes-in-anatomic-position-of-root-canal-orifices-in-pluriradicular-teeth-following-re-location-during-endodontic-treatment
#8
Darian Rusu, Petra Surlin, Stratul Stefan-Ioan, Marius Boariu, Calniceanu Horia, Adrian Kasaj, Cosmin Sinescu, Didilescu Andreea
Direct access to the root canals in posterior teeth for endodontic treatment is most frequently facilitated by the straightening of the coronal parts of the root canals, having as a consequence the relocation of the canal orifices on the map of the floor of the pulp chamber (Christie & Thompson, 1994). This procedure intentionally moves the coronal aspect of a canal away from the center of the chamber, while simultaneously removing internal dentin from the pulp chamber walls. The aim of this study was to evaluate the displacement resulting from the relocation of root canal orifices during the initial phase of rotary root canal treatment in molars using the dental operating microscope (DOM) and digital image processing...
February 16, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29457971/visible-light-photocatalysis-does-it-make-a-difference-in-organic-synthesis
#9
Leyre Marzo, Santhosh K Pagire, Oliver Reiser, Burkhard König
Visible light photocatalysis has evolved over the last decade into a widely used method in organic synthesis. For many important transformations, such as cross-coupling reactions, alpha-amino functionalizations, cycloadditions, ATRA reactions, or fluorinations, photocatalytic variants have been reported. In this review, we try to compare classical and photocatalytic procedures for selected classes of reactions and highlight their advantages and limitations. In many cases, the photocatalytic reactions proceed at milder reaction conditions, typically at room temperature, and stoichiometric reagents are replaced by simple oxidants or reductants, like air oxygen or amines...
February 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29457950/knowledge-and-skills-of-critical-care-nurses-in-assisting-with-intubation
#10
Chris Williams, Andrew Parry
Assisting with tracheal intubation is an aspect of clinical practice that requires knowledge and skill if the procedure is to be carried out in a timely and safe manner. Maintaining this knowledge and skill requires good quality education and regular opportunities to practise. These two factors appear to be inconsistent in critical care units. This article details an audit performed on a large tertiary referral centre critical care unit. It was undertaken in two phases: the first was a self-assessment of knowledge and the second was a practical assessment of the audit subjects in a simulated setting...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457933/computer-guided-inferior-alveolar-nerve-lateralization-with-simultaneous-implant-placement-a-preliminary-report
#11
Mohamed Atef, Mohamed Mounir
Placement of Dental implants in the posterior mandibular alveolar ridges may become a challenging procedure due to limited bone height between the crest of the ridge and the inferior alveolar canal. The aim of this study was to introduce an innovative, less invasive, highly accurate and easy surgical technique of inferior alveolar nerve lateralization in the posterior deficient mandible using a special customized 3D-printed surgical guide in order to enhance the bone height for implant placement. This was a case series study included 7 patients with unilateral edentulous mandibular alveolar ridges...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29457928/an-atraumatic-retractor-for-interdisciplinary-use-in-conventional-laparoscopy-and-robotic-surgery
#12
Ibrahim Alkatout
BACKGROUND: The removal of obstacles from the surgical field is a crucial aspect of any procedure in gynecological, urological or visceral laparoscopic surgery. Reliable instruments and skilled assistance are essential for the smooth execution of procedures. Blunt forceps are commonly used to keep tissue away from the operating field. The range of existing instruments has been enhanced by the introduction of laparoscopic retractors. However, no laparoscopic retractor can be used without causing tissue damage...
February 19, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29457906/optimized-phenotypic-biomarker-discovery-and-confounder-elimination-via-covariate-adjusted-projection-to-latent-structures-from-metabolic-spectroscopy-data
#13
Joram M Posma, Isabel Garcia-Perez, Timothy M D Ebbels, John C Lindon, Jeremiah Stamler, Paul Elliott, Elaine Holmes, Jeremy K Nicholson
Metabolism is altered by genetics, diet, disease status, environment and many other factors. Modelling either one of these is often done without considering the effects of the other covariates. Attributing differences in metabolic profile to one of these factors needs to be done while controlling for the metabolic influence of the rest. We describe here a data analysis framework and novel confounder-adjustment algorithm for multivariate analysis of metabolic profiling data. Using simulated data we show that similar numbers of true associations and significantly less false positives are found compared to other commonly used methods...
February 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29457872/simple-method-for-the-determination-of-personal-care-product-ingredients-in-lettuce-by-ultrasound-assisted-extraction-combined-with-solid-phase-microextraction-followed-by-gc-ms
#14
Jerónimo Cabrera-Peralta, Araceli Peña-Alvarez
A simple method for the simultaneous determination of personal care product ingredients: galaxolide, tonalide, oxybenzone, 4-methylbenzyliden camphor, padimate-o, 2-ethylhexyl methoxycinnamate, octocrylene, triclosan and methyl triclosan in lettuce by ultrasound-assisted extraction combined with solid-phase microextraction followed by gas chromatography with mass spectrometry was developed. Lettuce was directly extracted by ultrasound-assisted extraction with methanol, this extract was combined with water, extracted by solid-phase microextraction in immersion mode and analyzed by gas chromatography with mass spectrometry...
February 19, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29457852/successful-management-of-living-donor-liver-transplantation-for-biliary-atresia-with-single-ventricle-physiology-from-peri-transplant-through-total-cavopulmonary-connection-a-case-report
#15
Yohei Yamada, Ken Hoshino, Takayuki Oyanagi, Ryohei Gatayama, Jun Maeda, Nobuyuki Katori, Yasushi Fuchimoto, Taizo Hibi, Masahiro Shinoda, Kentaro Matsubara, Hideaki Obara, Ryo Aeba, Yuko Kitagawa, Hiroyuki Yamagishi, Tatsuo Kuroda
Children with single ventricle physiology have complete mixing of the pulmonary and systemic circulations, requiring staged procedures to achieve a separation of these circulations, or Fontan circulation. The single ventricle physiology significantly increases the risk of mortality in children undergoing non-cardiac surgery. As liver transplantation for patients with single ventricle physiology is particularly challenging, only a few reports have been published. We herein report a case of successful LDLTx for an 8-month-old pediatric patient with biliary atresia, heterotaxy, and complex heart disease of single ventricle physiology...
February 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29457755/novel-approach-for-ces1-genotyping-integrating-single-nucleotide-variants-and-structural-variation
#16
Ditte Bjerre, Henrik Berg Rasmussen
AIM: Development of a specific procedure for genotyping of CES1A1 (CES1) and CES1A2, a hybrid of CES1A1 and the pseudogene CES1P1. MATERIALS & METHODS: The number of CES1A1 and CES1A2 copies and that of CES1P1 were determined using real-time PCR. Long range PCRs followed by secondary PCRs allowed sequencing of single nucleotide variants in CES1A1 and CES1A2. Results & conlusion: A procedure consisting of two main steps was developed. Its first main step, the copy number determination, informed about presence of CES1A2 ...
February 19, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29457698/feasibility-of-a-novel-tacking-method-of-securing-mesh-in-transabdominal-preperitoneal-inguinal-hernia-repair-secure-tacking-against-recurrence
#17
Yoshio Nagahisa, Ryuju Kawashima, Ryu Matsumoto, Masaki Harada, Kazuki Hashida, Michio Okabe, Kazuyuki Kawamoto
INTRODUCTION: Postoperative chronic pain is an important outcome of hernia surgery. In laparoscopic hernia surgery, either fixation outside the trapezoid of disaster or no fixation is recommended to avoid postoperative pain. To avoid recurrence are transabdominal preperitoneal (TAPP) hernia repair, the myopectineal orifice must be covered with mesh during TAPP, but lifting or shrinking of the mesh can lead to recurrence. The aim of this study was to evaluate the feasibility of a novel technique for mesh fixation to prevent the mesh from lifting off...
February 19, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29457663/tandem-functionalization-in-one-highly-branched-polymer-with-layered-structure
#18
Xiaosong Cao, Yi Shi, Weiping Gan, Haifeng Gao
In this report, we developed a hyperbranched polymer with multi-layer structure to demonstrate the possibility of highly efficient tandem functionalization reactions at different domains within one nanostructured platform. The polymer scaffold was constructed using the chain-growth copper-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization of three functional monomers with sequential monomer addition in one pot. Subsequent reactions onto different monomer units exhibited efficient functionalization in each segment, constructing a highly sophisticated polymer structure via a robust procedure...
February 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29457654/chemoselective-glycosylation-of-peptides-via-s-alkylation-reaction
#19
Stefania De Luca, Enrica Calce, Valeria Manchise, Michele Saviano, Giuseppe Digilio
An efficient and fast procedure in execution for synthesizing S-linked glycopeptides is reported. It uses activated molecular sieves as a base to promote the selective S-alkylation of readily prepared cysteine-containing peptides, upon reaction of appropriate glycosyl halides. Due to the very mild conditions employed, the chemoselective linkage of the electrophilic sugar with a peptide sulfhydryl group occurred in a satisfactory yield, allowing the incorporation of mono and disaccharide moieties. The sugar-peptide conjugates obtained from α-D-glycosyl derivatives adopt a beta-S-conformation, indicating the high stereoselectivity of the substitution reaction...
February 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29457626/-transesophageal-echocardiography-in-adults-guidelines-of-the-working-group-on-echocardiography-of-the-polish-cardiac-society
#20
Piotr Lipiec, Janusz Bąk, Wojciech Braksator, Marcin Fijałkowski, Andrzej Gackowski, Zbigniew Gąsior, Jarosław D Kasprzak, Anna Klisiewicz, Mirosław Kowalski, Tomasz Kukulski, Katarzyna Mizia-Stec, Edyta Płońska-Gościniak, Piotr Pruszczyk, Bożena Sobkowicz, Piotr Szymański, Andrzej Szyszka, Olga Trojnarska, Andrzej Wysokiński, Piotr Hoffman
This document presents current Polish guidelines on the clinical use of transesophageal echocardiography, including guidance of percutaneous procedures and intraoperative echocardiography, in adult patients. The authors present recommendations regarding indications and contraindications, staff and equipment requirements, patient preparation and information, examination protocol, reporting and reimbursement.
2018: Kardiologia Polska
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