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https://www.readbyqxmd.com/read/28749320/reliability-of-heart-rate-mobile-apps-in-young-healthy-adults-exploratory-study-and-research-directions
#1
Maria Parpinel, Laura Scherling, Stefano Lazzer, Vincenzo Della Mea
BACKGROUND: Recently, a number of smartphone apps appeared that allow for heart rate measurements basing on the photoplethysmography principle. In fact, almost every smartphone now has a camera with flash that could be used for that. Some studies appeared on the reliability of some of those apps, with heterogeneous results. OBJECTIVES: The present study aims at adding up evidence in particular during physical activity, by comparing 3 apps on two different platforms (IOs and Android), on a broad range of heart rates...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749249/an-autopsy-verified-case-of-steroid-responsive-encephalopathy-with-convulsion-and-a-false-positive-result-from-the-real-time-quaking-induced-conversion-assay
#2
Yuichi Hayashi, Yasushi Iwasaki, Nobuaki Yoshikura, Takahiko Asano, Maya Mimuro, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Mari Yoshida, Takashi Inuzuka
We report an autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion (RT-QUIC) assay. A 61-year-old Japanese man presented with acute onset of consciousness disturbance, and convulsions, but without a past medical or family history of progressive dementia, epilepsy, or prion disease. Brain diffusion and fluid-attenuated inverted recovery MR images revealed edematous cortical hyper-intensity, which diminished after the acute phase...
July 27, 2017: Prion
https://www.readbyqxmd.com/read/28748967/melanocytic-nevi-and-non-neoplastic-hyperpigmentations
#3
C Clemente
This is the first of three chapters that will be progressively published on Pathologica as updating activity of the Italian Study Group of Dermatopathology (GISD), Italian Society of Pathology and Cytology (SIAPeC IAP). The first chapter concerns non-neoplastic hyperpigmented skin lesions and nevi, the second will address the topics of dysplastic nevus, borderline and low malignant potential melanocytic proliferations and the third melanoma in its variants and differential diagnoses with a supplement on the immunohistochemistry and molecular support to diagnostic and prognostic definition of nevi and melanomas...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748836/morphometric-and-morphological-appraisal-of-the-eggs-of-anopheles-stephensi-diptera-culicidae-from-india
#4
Varun Tyagi, Sunil Dhiman, Ajay K Sharma, A R Srivastava, Bipul Rabha, D Sukumaran, Vijay Veer
BACKGROUND & OBJECTIVES: Anopheles stephensi is one of the most important urban malaria vectors in India and contribute about 12% of total malaria cases. An. stephensi has three ecological variants; type, intermediate and mysorensis that can be differentiated on the basis of differences in number of ridges on egg float and on the basis of spiracular indices. Because of its anthropophilic nature the 'type' form is an efficient malaria vector. In the present study, the egg surface morphometry and morphology of An...
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28748523/management-and-prevention-of-saphenous-vein-graft-failure-a-review
#5
REVIEW
Peter McKavanagh, Bobby Yanagawa, George Zawadowski, Asim Cheema
Coronary artery bypass grafting (CABG) remains a vital treatment for patients with multivessel coronary artery disease (CAD), especially diabetics. The long-term benefit of the internal thoracic artery graft is well established and remains the gold standard for revascularization of severe CAD. It is not always possible to achieve complete revascularization through arterial grafts, necessitating the use of saphenous vein grafts (SVG). Unfortunately, SVGs do not have the same longevity, and their failure is associated with significant adverse cardiac outcomes and mortality...
July 26, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28748465/automated-patch-clamp-methods-for-the-herg-cardiac-potassium-channel
#6
Sylvie Houtmann, Brigitte Schombert, Camille Sanson, Michel Partiseti, G Andrees Bohme
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced function of this potassium channel involved in the repolarization of the cardiac action potential can produce a type of life-threatening cardiac ventricular arrhythmias called Torsades de Pointes (TdP). Therefore, hERG inhibitory activity of newly synthetized molecules is a relevant structure-activity metric for compound prioritization and optimization in medicinal chemistry phases of drug discovery...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28748414/the-effect-of-arterial-curvature-on-blood-flow-in-arterio-venous-fistulae-realistic-geometries-and-pulsatile-flow
#7
L Grechy, F Iori, R W Corbett, W Gedroyc, N Duncan, C G Caro, P E Vincent
Arterio-Venous Fistulae (AVF) are regarded as the "gold standard" method of vascular access for patients with End-Stage Renal Disease (ESRD) who require haemodialysis. However, up to 60% of AVF do not mature, and hence fail, as a result of Intimal Hyperplasia (IH). Unphysiological flow and oxygen transport patterns, associated with the unnatural and often complex geometries of AVF, are believed to be implicated in the development of IH. Previous studies have investigated the effect of arterial curvature on blood flow in AVF using idealized planar AVF configurations and non-pulsatile inflow conditions...
July 26, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28748149/the-prognostic-value-of-residual-coronary-stenoses-after-functionally-complete-revascularisation
#8
EDITORIAL
Dennis T L Wong
Fractional flow reserve (FFR) has become the gold standard for functional assessment of coronary artery stenosis. Studies have confirmed the superiority of FFR guided percutaneous coronary intervention (PCI) compared to angiography guided PCI. Due to the high cost of FFR, it is not economically viable for FFR to be incorporated into every routine invasive coronary angiography. As a result, visual estimation of diameter stenosis on invasive coronary angiography still remains the cornerstone for decision making regarding revascularisation treatment for patients...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28748116/gout-an-old-disease-in-new-perspective-a-review
#9
REVIEW
Gaafar Ragab, Mohsen Elshahaly, Thomas Bardin
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747737/open-source-software-for-automatic-detection-of-cone-photoreceptors-in-adaptive-optics-ophthalmoscopy-using-convolutional-neural-networks
#10
David Cunefare, Leyuan Fang, Robert F Cooper, Alfredo Dubra, Joseph Carroll, Sina Farsiu
Imaging with an adaptive optics scanning light ophthalmoscope (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina. Quantitative analysis of AOSLO images typically requires manual grading, which is time consuming, and subjective; thus, automated algorithms are highly desirable. Previously developed automated methods are often reliant on ad hoc rules that may not be transferable between different imaging modalities or retinal locations. In this work, we present a convolutional neural network (CNN) based method for cone detection that learns features of interest directly from training data...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747190/bone-mineral-density-in-people-living-with-hiv-a-narrative-review-of-the-literature
#11
REVIEW
M J Kruger, T A Nell
Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public health concern. Changing nutritional, as well as social behaviour, play integral roles in the prevalence and incidence of decreased BMD. Furthermore, human immunodeficiency virus (HIV) specifically, has a negative impact on BMD and although highly active antiretroviral therapy increases the prognosis for HIV-infected individuals, BMD still seem to decrease further...
July 26, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28747097/tissue-engineering-strategies-to-improve-osteogenesis-in-the-juvenile-swine-alveolar-cleft-model
#12
Montserrat Caballero, Donna C Jones, Zhengyuan Shan, Sajjad Soleimani, John A van Aalst
Alveolar <b>(gumline)</b> clefts are the most common congenital bone defect in humans, affecting 1 in 700 live births. Treatment <b>to repair these bony</b> defects relies on autologous, <b>cancellous</b> bone transfer from the iliac crest. This harvest requires a second surgical site <b>with increased </b>surgical time associated with potential complications, <b>while providing only limited cancellous bone</b>. Improvements in treatment protocols that avoid these limitations would be beneficial to patients with clefts and other craniofacial bone defects...
July 26, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28746177/correlation-between-high-intensity-zone-on-mri-and-discography-in-patients-with-low-back-pain
#13
Huadong Wang, Zhonghai Li, Chunli Zhang, Weisheng Zhang, Li Li, Jidong Guo, Wenwen Wu, Shuxun Hou
The aim of this study was to analyze the correlation between high-intensity zone (HIZ) on magnetic resonance imaging (MRI) of a lumbar disc and positive pain response assessed by discography for the diagnosis and treatment of discogenic low back pain (LBP). Thirty-seven patients aged 21 to 59 years with chronic LBP but without any neurological symptoms or lumbar disc herniation who underwent MRI and subsequent discography were included in this study. During discography, concordant pain was regarded as positive, whereas discordant pain and no pain were regarded as negative...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746125/comparison-of-pedicle-screw-fixation-strength-among-different-transpedicular-trajectories-a-finite-element-study
#14
Keitaro Matsukawa, Yoshiyuki Yato, Richard A Hynes, Hideaki Imabayashi, Naobumi Hosogane, Yasuo Yoshihara, Takashi Asazuma, Koichi Nemoto
STUDY DESIGN: Comparative biomechanical study by finite element (FE) method. OBJECTIVE: To investigate the pullout strength of pedicle screws using different insertional trajectories. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation has become the gold standard for spinal fusion, however, not much has been done to clarify how the fixation strength of pedicle screws are affected by insertional trajectories and bone properties. MATERIALS AND METHODS: Three-dimensional FE models of 20 L4 vertebrae were constructed from the computed tomographic data...
August 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28746018/splenic-abscess-in-immunocompetent-patients-managed-primarily-without-splenectomy-a-series-of-7-cases
#15
S Divyashree, Nikhil Gupta
INTRODUCTION: Splenic abscesses are rare in immunocompetent adults. Despite advances in diagnosis and treatment, these abscesses are still potentially life threatening. Various factors have been reported to predispose otherwise immunocompetent adults to splenic abscesses. Splenectomy was once considered the "gold standard" treatment. However, the trend is shifting to a conservative approach. CASE DESCRIPTION: We describe seven cases of splenic abscess in immunocompetent adults, the cause of which ranged from tuberculosis to salmonella and was as rare as Plasmodium vivax...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28745560/genetic-perspective-of-uniparental-mitochondrial-dna-landscape-on-the-punjabi-population-pakistan
#16
Shahzad Bhatti, Sana Abbas, Muhammad Aslamkhan, Marcella Attimonelli, Magali Segundo Trinidad, Hikmet Hakan Aydin, Erica Martinha Silva de Souza, Gerardo Rodriguez Gonzalez
To investigate the uniparental genetic structure of the Punjabi population from mtDNA aspect and to set up an appropriate mtDNA forensic database, we studied maternally unrelated Punjabi (N = 100) subjects from two caste groups (i.e. Arain and Gujar) belonging to territory of Punjab. The complete control region was elucidated by Sanger sequencing and the subsequent 58 different haplotypes were designated into appropriate haplogroups according to the most recently updated mtDNA phylogeny. We found a homogenous dispersal of Eurasian haplogroup uniformity among the Punjab Province and exhibited a strong connotation with the European populations...
July 26, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28745132/joint-incorporation-of-randomised-and-observational-evidence-in-estimating-treatment-effects
#17
John Ferguson, Alberto Alvarez-Iglesias, John Newell, John Hinde, Martin O' Donnell
In evidence-based medicine, randomised trials are regarded as a gold standard in estimating relative treatment effects. Nevertheless, a potential gain in precision is forfeited by ignoring observational evidence. We describe a simple estimator that combines treatment estimates from randomised and observational data and investigate its properties by simulation. We show that a substantial gain in estimation accuracy, compared with the estimator based solely on the randomised trial, is possible when the observational evidence has low bias and standard error...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28745012/validation-of-the-early-detection-primary-care-checklist-in-an-italian-community-help-seeking-sample-the-checklist-per-la-valutazione-dell-esordio-psicotico
#18
Lorenzo Pelizza, Andrea Raballo, Enrico Semrov, Luigi Rocco Chiri, Silvia Azzali, Ilaria Scazza, Sara Garlassi, Federica Paterlini, Francesca Fontana, Rosanna Favazzo, Luana Pensieri, Michela Fabiani, Leonardo Cioncolini, Simona Pupo
BACKGROUND: To establish the concordant validity of the "Checklist per la Valutazione dell'Esordio Psicotico" (CVEP) in an Italian help-seeking population. The CVEP is the Italian adaptation of the "early detection Primary Care Checklist," a 20-item tool specifically designed to assist primary care practitioners in identifying young people in the early stages of psychosis. METHODS: The checklist was completed by the referring practitioners of 168 young people referred to the "Reggio Emilia At Risk Mental States" Project, an early detection infrastructure developed under the aegis of the Regional Project on Early Detection of Psychosis in the Reggio Emilia Department of Mental Health...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28744859/lateral-and-axial-cutting-efficiency-of-instruments-manufactured-with-conventional-nickel-titanium-and-novel-gold-metallurgy
#19
R A Vasconcelos, A Arias, O A Peters
AIM: To isolate the effect of metallurgy in lateral and axial cutting efficacy against plastic and bovine dentine substrates by comparing two rotary systems with identical design but manufactured with either conventional nickel-titanium or heat-treated gold alloy. METHODOLOGY: A total of 258 ProTaper Universal (PTU) and ProTaper Gold (PTG) Shaping instruments were used. Bending behaviour was assessed to determine the appropriate displacement associated with a 2 N force in lateral cutting...
July 26, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28744842/the-quantitative-structural-and-compositional-analyses-of-degenerating-intervertebral-discs-using-magnetic-resonance-imaging-and-contrast-enhanced-micro-computed-tomography
#20
Kevin H Lin, Simon Y Tang
The intervertebral disc (IVD) is susceptible to degenerative changes that are associated with low back pain. Murine models are often used to investigate the mechanistic changes in the development, aging, and diseased states of the IVD, yet the detection of early degenerative changes in structure is challenging because of the minute size of the murine IVDs. Histology is the gold standard for examining the IVD structure, but it is susceptible to sectioning artifacts, spatial biases, and requires the destructive preparation of the sample...
July 25, 2017: Annals of Biomedical Engineering
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