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https://www.readbyqxmd.com/read/28717397/how-do-we-avoid-disaster-when-exiting-the-european-medicines-agency-making-the-most-of-brexit-in-pharmaceutical-regulation
#1
EDITORIAL
Anthony James Hatswell
As the UK prepares to leave the EU, it must decide what path it is to take with a large number of regulatory and technical agencies who provide collaboration at the European level. In the case of pharmaceuticals, the European Medicines Agency (EMA) provides pan-European licencing for novel pharmaceuticals. Should the UK depart from the EMA system, this article highlights the loss to patients immediately (slower access to novel treatments), and in the long term by having no access to some novel products as companies choose not to launch in the UK...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28714811/policymap-mapping-social-determinants-of-health
#2
Yunting Fu, Sharon Whitfield, Tyler Nix
PolicyMap is a mapping resource from The Reinvestment Fund that offers access to a range of demographic and health-related data, including chronic disease incidence, health care provider locations, food access, mass transit, and other social determinates of health. This column features a sample search and describes the types of outputs available with PolicyMap.
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28711892/3-d-bioprinting-law-regulation-perspectives
#3
Vitalii Pashkov, Andrii Harkusha
INTRODUCTION: Achieved level of technical progress moves us closer and closer to practical use of 3-d bioprinting technologies in real life. Such perspective raise a wide variety of crucial legal issues from the acceptable model of regulation of the science and its' societal effects to problems of the commercialization of the technology and potential restrictions of its use. Some key points on concept of legal regulation of abovementioned sphere is a base of this study. MATERIAL AND METHODS: Scientific discussion on 3-D bioprinting, European Union`s and US experience in patenting of 3-D bioprinting technologies, European Medicine Agency (EMA) or the US Food and Drug Administration (FDA) regulations, European Medical Technology Industry Association (EUCOMED) Acts...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711521/a-comparison-of-resetting-and-nonresetting-contingencies-in-progressive-duration-schedules
#4
Morgan Valois, Sara Peck, Tom Byrne
We compared two progressive schedules of reinforcement in which rats received access to sweetened condensed milk for depressing and holding down a response lever. Duration requirements increased after each reinforcer delivery in a manner similar to progressive-ratio schedules. Under one schedule, any response duration less than that required for reinforcement had no programmed consequences. Under the second schedule, the cumulative duration of all responses could meet the reinforcement criteria. Breaking points were consistently higher when all lever presses, regardless of duration, contributed to meeting the reinforcer requirements...
July 12, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28708736/mifepristone-plasma-level-and-glucocorticoid-receptor-antagonism-associated-with-response-in-patients-with-psychotic-depression
#5
Thaddeus Block, Georgios Petrides, Harvey Kushner, Ned Kalin, Joseph Belanoff, Alan Schatzberg
BACKGROUND: Psychotic depression has no Food and Drug Administration-approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing a biologically targeted treatment opportunity. The purpose of this study was to explore the clinical and biological effects of short-duration (7-day) glucocorticoid receptor antagonism with mifepristone and the role of mifepristone plasma levels in patients with psychotic depression. METHODS: This double-blind, randomized study took place at 34 US clinical research centers and included patients with a diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, major depressive disorder, severe, with psychotic features...
July 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28708245/health-equity-issues-related-to-childhood-obesity-a-scoping-review
#6
Clemencia M Vargas, Elsie M Stines, Herta S Granado
PURPOSE: The purpose of this scoping review was to determine the health-equity issues that relate to childhood obesity. METHODS: Health-equity issues related to childhood obesity were identified by analyzing food environment, natural and built environment, and social environment. The authors searched Medline, PubMed, and Web of Science, using the keywords "children" and "obesity." Specific terms for each environment were added: "food desert," "advertising," "insecurity," "price," "processing," "trade," and "school" for food environment; "urban design," "land use," "transportation mode," "public facilities," and "market access" for natural and built environment; and "financial capacity/poverty," "living conditions," "transport access," "remoteness," "social support," "social cohesion," "working practices," "eating habits," "time," and "social norms" for social environment...
July 14, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28707111/limiting-the-cost-of-mutualism-the-defensive-role-of-elongated-gynophore-in-the-leafflower-moth-mutualism
#7
Saori Furukawa, Atsushi Kawakita
Mutualisms are interactions from which both partners benefit but may collapse if mutualists' costs and benefits are not aligned. Host sanctions are one mechanism whereby hosts selectively allocate resources to the more cooperative partners and thereby reduce the fitness of overexploiters; however, many mutualisms lack apparent means of host sanctions. In mutualisms between plants and pollinating seed parasites, such as those between leafflowers and leafflower moths, pollinators consume subsets of the seeds as larval food in return for their pollination service...
July 14, 2017: Oecologia
https://www.readbyqxmd.com/read/28706778/evaluation-of-healthy2go-a-country-store-transformation-project-to-improve-the-food-environment-and-consumer-choices-in-appalachian-kentucky
#8
Joshua A Rushakoff, Daniel E Zoughbie, Nancy Bui, Katerina DeVito, Leila Makarechi, Hitomi Kubo
Rates of obesity and type 2 diabetes in Kentucky's Cumberland Valley region are among the highest in the United States and limited access to healthy food contributes to these epidemics. The aim of Healthy2Go (H2G), a country store transformation project launched by Spread the Health Appalachia (STHA), was to improve awareness and availability of healthy options in small, rural stores. Ten country stores participated in H2G and received training and technical assistance to increase availability and awareness of healthy foods...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28706311/first-report-of-the-fig-cyst-nematode-heterodera-fici-kirjanova-on-fig-tree-ficus-carica-in-ontario-canada
#9
Fengcheng Sun, Neil Henry, Qing Yu
Although fig trees are a popular ornamental fruit tree in subtropical regions, some hardy species, such as Ficus carica, have been grown in the west coast of British Columbia and southern Ontario in Canada. The fig cyst nematode, Heterodera fici Kirjanova, is a pest on fig plants, and the heavy infestation can cause retarded growth and yellowing of leaves (Maqbool et al., 1987). In the spring of 2016, a sample of rhizosphere from a potted fig (F. carica) seedling was submitted to the Nematology Laboratory, Canadian Food Inspection Agency...
June 2017: Journal of Nematology
https://www.readbyqxmd.com/read/28704944/sphenostylis-stenocarpa-ex-a-rich-harms-a-fading-genetic-resource-in-a-changing-climate-prerequisite-for-conservation-and-sustainability
#10
Catherine Veronica Nnamani, Sunday Adesola Ajayi, Happiness Ogba Oselebe, Christopher John Atkinson, Anastasia Ngozi Igboabuchi, Eucharia Chizoba Ezigbo
The southeastern part of Nigeria is one of the major hotspots of useful plant genetic resources. These endemic species are associated with a rich indigenous knowledge and cultural diversity in relation to their use and conservation. Sphenostylis stenocarpa (ex. A. Rich.) Harms., (African Yam Bean (AYB)), is one such crop within the family of Fabaceae. Its nutritional and eco-friendly characteristics have value in ameliorating malnutrition, hidden hunger and environmental degradation inherent in resource-poor rural and semi-rural communities throughout Africa...
July 12, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28704674/urban-growth-and-water-access-in-sub-saharan-africa-progress-challenges-and-emerging-research-directions
#11
REVIEW
S Dos Santos, E A Adams, G Neville, Y Wada, A de Sherbinin, E Mullin Bernhardt, S B Adamo
For the next decade, the global water crisis remains the risk of highest concern, and ranks ahead of climate change, extreme weather events, food crises and social instability. Across the globe, nearly one in ten people is without access to an improved drinking water source. Least Developed Countries (LDCs) especially in sub-Saharan Africa (SSA) are the most affected, having disproportionately more of the global population without access to clean water than other major regions. Population growth, changing lifestyles, increasing pollution and accelerating urbanization will continue to widen the gap between the demand for water and available supply especially in urban areas, and disproportionately affect informal settlements, where the majority of SSA's urban population resides...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28701300/duodenal-and-ileal-glucose-infusions-differentially-alter-gastrointestinal-peptides-appetite-response-and-food-intake-a-tube-feeding-study
#12
Sally D Poppitt, Hyun Sang Shin, Anne-Thea McGill, Stephanie C Budgett, Kim Lo, Malcolm Pahl, Janice Duxfield, Mark Lane, John R Ingram
Background: Activation of the ileal brake through the delivery of nutrients into the distal small intestine to promote satiety and suppress food intake provides a new target for weight loss. Evidence is limited, with support from naso-ileal lipid infusion studies.Objective: The objective of the study was to investigate whether glucose infused into the duodenum and ileum differentially alters appetite response, food intake, and secretion of satiety-related gastrointestinal peptides.Design: Fourteen healthy male participants were randomly assigned to a blinded 4-treatment crossover, with each treatment of single-day duration...
July 12, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28701220/identification-of-qtl-with-large-effect-on-seed-weight-in-a-selective-population-of-soybean-with-genome-wide-association-and-fixation-index-analyses
#13
Long Yan, Nicolle Hofmann, Shuxian Li, Marcio Elias Ferreira, Baohua Song, Guoliang Jiang, Shuxin Ren, Charles Quigley, Edward Fickus, Perry Cregan, Qijian Song
BACKGROUND: Soybean seed weight is not only a yield component, but also a critical trait for various soybean food products such as sprouts, edamame, soy nuts, natto and miso. Linkage analysis and genome-wide association study (GWAS) are two complementary and powerful tools to connect phenotypic differences to the underlying contributing loci. Linkage analysis is based on progeny derived from two parents, given sufficient sample size and biological replication, it usually has high statistical power to map alleles with relatively small effect on phenotype, however, linkage analysis of the bi-parental population can't detect quantitative trait loci (QTL) that are fixed in the two parents...
July 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28700928/molecular-state-of-the-membrane-active-antibiotic-daptomycin
#14
Ming-Tao Lee, Wei-Chin Hung, Meng-Hsuan Hsieh, Hsiung Chen, Yu-Yung Chang, Huey W Huang
Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic membranes of Gram-positive pathogens, causing membrane permeabilization to ions and cell death. The antibiotic activity is calcium-ion dependent and correlates with the target membrane's content of phosphatidylglycerol (PG). For such a complex reaction with membranes, it has been difficult to uncover the molecular process that underlies its antibacterial activity...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28699098/effects-of-a-2014-statewide-policy-change-on-cash-value-voucher-redemptions-for-fruits-vegetables-among-participants-in-the-supplemental-nutrition-program-for-women-infants-and-children-wic
#15
Janice O Okeke, Ruwani M Ekanayake, Melissa L Santorelli
Purpose In 2014, the New Jersey Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) began requiring WIC-authorized stores to stock at least two fresh fruits and two fresh vegetables. We aimed to evaluate the effect of this policy change on fruit and vegetable purchases among WIC-participating households and to assess variation by household access to a healthy food store such as a supermarket or large grocery store. Description Households with continuous WIC enrollment from June 2013 to May 2015 were included (n = 16,415)...
July 12, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28697616/perceptions-attitudes-and-challenges-about-obesity-and-adopting-a-healthy-lifestyle-among-health-workers-in-pietermaritzburg-kwazulu-natal-province
#16
Patrick Simfukwe, Brian Van Wyk, Charl Swart
BACKGROUND: The prevalence of obesity is reported to be high and increasing among health workers, in both high-income and low-income countries, which in turn is a common risk factor for all non-communicable diseases. This is alarming, as health workers not only serve the community's health needs but should also serve as role models for a healthy lifestyle. It is therefore important that obesity among health workers is addressed and prevented. OBJECTIVE: The aim of the study was to explore perceptions and attitudes about obesity among health workers in three selected hospitals in Pietermaritzburg, and to identify the barriers to adopting a healthy lifestyle...
June 22, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28696546/effect-of-germination-and-extrusion-on-physicochemical-properties-and-nutritional-qualities-of-extrudates-and-tortilla-from-wheat
#17
Lijia Zhu, Akinbode A Adedeji, Sajid Alavi
Wheat is the most common grain in the temperate region. Modifying its constituent through food processing improves its functionality and nutrient access. In this study, the combined effect of germination and extrusion on physicochemical properties and nutritional qualities of extrudates and tortilla from wheat was evaluated. Results showed that germination significantly increased (P <0.05) the γ-aminobutyric acid content in germinated whole wheat (GW) and extruded germinated whole wheat (EGW) as compared to the control of whole wheat (WW)...
July 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28694825/rapid-separation-of-indole-glucosinolates-in-roots-of-chinese-cabbage-brassica-rapa-subsp-pekinensis-by-high-performance-liquid-chromatography-with-diode-array-detection
#18
Alfredo Aires, Rosa Carvalho
Glucosinolates are a class of sulphur-containing plant compounds with diverse biological properties. They have been found exclusively in the Brassicaceae family plants and studied exhaustively in biosynthetic and application perspectives. The aim of this current study is to present a simple and updated method to quantify indole glucosinolate content in hairy root cultures of Chinese cabbage by HPLC-DAD-UV/Vis. Method validation controls were performed and recovery experiments were assayed. The data was statically treated and compared with published works...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28693670/the-right-to-food-and-the-planetary-boundaries-framework
#19
Wiebina Heesterman
The 'Right to Food' is a legal entitlement owed to all human beings established in international law more than half a century ago. Fulfilment of the right has been entrusted to states parties to the 1966 International Covenant on Economic, Social and Cultural Rights (ICESCR). However, in practice, the right is often breached because of hostility or indifference from individuals or institutions refusing access to provisions, or because of vicissitudes of nature. Adverse impacts due to human interference in natural processes are increasingly noticeable in the area of food production...
March 1, 2017: Science Progress
https://www.readbyqxmd.com/read/28692485/safety-and-tolerability-of-cariprazine-in-patients-with-acute-exacerbation-of-schizophrenia-a-pooled-analysis-of-four-phase-ii-iii-randomized-double-blind-placebo-controlled-studies
#20
Willie Earley, Suresh Durgam, Kaifeng Lu, István Laszlovszky, Marc Debelle, John M Kane
Cariprazine, a potent dopamine D3 and D2 receptor partial agonist antipsychotic with preferential binding to D3 receptors, is Food and Drug Administration approved for treating schizophrenia and manic or mixed episodes of bipolar I disorder. A post-hoc safety/tolerability analysis of data from the four acute trials in the cariprazine schizophrenia clinical development program (NCT00404573; NCT00694707; NCT01104766; NCT01104779) was carried out using the overall safety population (all patients who received ≥1 dose of study drug) and modal daily dose subgroups (1...
July 7, 2017: International Clinical Psychopharmacology
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