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https://www.readbyqxmd.com/read/28542506/impact-evaluation-of-different-cash-based-intervention-modalities-on-child-and-maternal-nutritional-status-in-sindh-province-pakistan-at-6-mo-and-at-1-y-a-cluster-randomised-controlled-trial
#1
Bridget Fenn, Tim Colbourn, Carmel Dolan, Silke Pietzsch, Murtaza Sangrasi, Jeremy Shoham
BACKGROUND: Cash-based interventions (CBIs), offer an interesting opportunity to prevent increases in wasting in humanitarian aid settings. However, questions remain as to the impact of CBIs on nutritional status and, therefore, how to incorporate them into emergency programmes to maximise their success in terms of improved nutritional outcomes. This study evaluated the effects of three different CBI modalities on nutritional outcomes in children under 5 y of age at 6 mo and at 1 y. METHODS AND FINDINGS: We conducted a four-arm parallel longitudinal cluster randomised controlled trial in 114 villages in Dadu District, Pakistan...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28542394/incorporating-public-priorities-in-the-ocean-health-index-canada-as-a-case-study
#2
Rémi M Daigle, Philippe Archambault, Benjamin S Halpern, Julia S Stewart Lowndes, Isabelle M Côté
The Ocean Health Index (OHI) is a framework to assess ocean health by considering many benefits (called 'goals') provided by the ocean provides to humans, such as food provision, tourism opportunities, and coastal protection. The OHI framework can be used to assess marine areas at global or regional scales, but how various OHI goals should be weighted to reflect priorities at those scales remains unclear. In this study, we adapted the framework in two ways for application to Canada as a case study. First, we customized the OHI goals to create a national Canadian Ocean Health Index (COHI)...
2017: PloS One
https://www.readbyqxmd.com/read/28542036/a-survey-of-renal-impairment-pharmacokinetic-studies-for-new-oncology-drug-approvals-in-the-usa-from-2010-to-early-2015-a-focus-on-development-strategies-and-future-directions
#3
Jim J Xiao, Jiyun S Chen, Bert L Lum, Richard A Graham
The US Food and Drug Administration (FDA) issued a guidance document in 2010 on pharmacokinetic (PK) studies in renal impairment (RI) on the basis of observations that substances such as uremic toxins might result in altered drug metabolism and excretion. No specific recommendations for oncology drugs were included. We surveyed the publicly available FDA review documents of 29 small molecule oncology drugs approved between 2010 and the first quarter of 2015. The objectives were as follows: (i) summarize the impact of RI on PK at the time of the initial new drug application; (ii) identify limitations of the guidance; and (iii) outline an integrated approach to study the impact of RI on these drugs...
May 24, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28541498/how-food-insecurity-could-lead-to-obesity-in-lmics-%C3%A2-when-not-enough-is-too-much-a-realist-review-of-how-food-insecurity-could-lead-to-obesity-in-low-and-middle-income-countries
#4
Penny Farrell, Anne Marie Thow, Seye Abimbola, Neha Faruqui, Joel Negin
While food insecurity is a well-known cause of under-nutrition and stunting, in recent decades it has also been linked with obesity. Understanding and thus minimising the risk factors for obesity in low- and middle-income country contexts, which often lack the health system capacity to treat the consequent obesity-related illnesses, is crucial. This study adopted realist review methodology because it enabled us to analyse and organise the evidence from low- and middle-income countries into a coherent scheme...
May 24, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28541467/global-epidemiology-of-ctx-m-%C3%AE-lactamases-temporal-and-geographical-shifts-in-genotype
#5
Edward R Bevan, Annie M Jones, Peter M Hawkey
Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation...
May 25, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28539267/computational-prediction-integrating-the-inhibition-kinetics-of-gallotannin-on-%C3%AE-glucosidase
#6
Li-Mei Yue, Jinhyuk Lee, Li Zheng, Yong-Doo Park, Zhuo-Ming Ye, Jun-Mo Yang
Due to the finding that inhibition of α-glucosidase is directly associated with treatment of several diseases, the development of a selective inhibitor for targeting α-glucosidase is important. Gallotannin (GT) is a natural ingredient that has been used as a food additive and for medicinal applications. In this study, we performed a computational docking experiment involving the pre-simulation of the binding mechanism of GT, and the effect of GT on α-glucosidase was evaluated with inhibitory kinetics based on its polyphenol properties...
May 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28538914/the-regulation-and-adoption-of-health-technologies-under-brazil-s-unified-health-system-barriers-to-access-to-medicines-for-diseases-of-poverty
#7
Rafael Santos Santana, Evandro de Oliveira Lupatini, Silvana Nair Leite
The study aimed to examine the regulation and adoption of health technologies for the diseases of poverty in the Brazil's Unified Health System (SUS). An exploratory, descriptive study was conducted between January and May 2016 consisting of the search and analysis of relevant documents on the websites of Brazil's National Health Surveillance Agency, the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), the National Commission for the Adoption of Technologies by the SUS, and Saúde Legis (the Ministry of Health's Legislation System)...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538853/-social-programs-and-reducing-obesity-in-peru-reflections-from-the-research
#8
Francisco Diez-Canseco, Lorena Saavedra-Garcia
In recent decades, overweight or obesity have increased dramatically in middle- and low-income countries; a situation which consolidates chronic non-communicable diseases (NCD) as one of the leading causes of mortality and disability worldwide. Currently, half the people in Peru over the age of 15 years are overweight, and one fifth suffer from obesity. The situation is worsening and increasingly affects people in poverty, who frequently benefit from food supplement programs designed to combat food insecurity and malnutrition...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538841/-nutritional-traffic-light-system-for-processed-foods-qualitative-study-of-awareness-understanding-attitudes-and-practices-in-ecuador
#9
Wilma B Freire, William F Waters, Gabriela Rivas-Mariño
Objectives.: To analyze awareness, understanding, attitudes, and practices related to the nutritional traffic light system (NTLS) on processed food packaging in Ecuador. Materials and methods.: 21 discussions were held in focus groups (FG) in populations of various sizes in the coastal, mountainous, and eastern regions. Nine interviews were conducted with key informants (KI) representing large, medium, and small enterprises producing or selling processed foods. Results...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28537330/-eating-together-is-associated-with-food-behaviors-and-demographic-factors-of-older-japanese-people-who-live-alone
#10
M Ishikawa, Y Takemi, T Yokoyama, K Kusama, Y Fukuda, T Nakaya, M Nozue, N Yoshiike, K Yoshiba, F Hayashi, N Murayama
OBJECTIVE: This study aimed to examine the relationships between eating together and subjective health, frailty, food behaviors, food accessibility, food production, meal preparation, alcohol intake, socioeconomic factors and geography among older Japanese people who live alone. DESIGN: A cross-sectional, multilevel survey was designed. The questionnaire was distributed by post and self-completed by participants. SETTING: The sample was drawn from seven towns and cities across Japan...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28537087/a-comparison-of-characteristics-and-food-insecurity-coping-strategies-between-international-and-domestic-postsecondary-students-using-a-food-bank-located-on-a-university-campus
#11
Mahitab Hanbazaza, Geoff D C Ball, Anna P Farmer, Katerina Maximova, Jasmine Farahbakhsh, Noreen D Willows
PURPOSE: We compared food insecurity status, coping strategies, demographic characteristics, and self-rated health of international and domestic postsecondary students requesting emergency food hampers from a campus food bank (CFB). METHODS: We collected data from a cross-sectional convenience sample of domestic and international students who accessed the CFB at the University of Alberta. RESULTS: Food insecurity was prevalent (international students: n = 26/27 (96...
May 24, 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28536592/trait-associations-in-diversity-panels-of-the-two-common-bean-phaseolus-vulgaris-l-gene-pools-grown-under-well-watered-and-water-stress-conditions
#12
Asrat Asfaw, Daniel Ambachew, Trushar Shah, Matthew W Blair
Common beans are a warm-season, food legume cultivated in areas prone to water limitation throughout their growing season. This study assessed the magnitude and pattern of trait associations for a total of 202 common bean genotypes divided into panels of 81 Andean and 121 Mesoamerican gene pool accessions grown under contrasting treatments of well-watered, non-stress, and water-limited, terminal drought-stress conditions. Linear correlation, complex path coefficient, and genetic divergence analyses were used to dissect the relationship dynamics between traits and the relative contribution of adaptive traits to differentiation among gene pools and genotypes based on drought stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28535737/the-influence-of-migration-on-dietary-practices-of-ghanaians-living-in-the-united-kingdom-a-qualitative-study
#13
Hibbah Araba Osei-Kwasi, Katie Powell, Mary Nicolaou, Michelle Holdsworth
BACKGROUND: Previous studies have identified a process of dietary acculturation when migrant groups adopt the food patterns of the host country. AIM: The aim of this study was to explore the influence of migration on dietary practices and the process of dietary acculturation amongst Ghanaians living in the UK. SUBJECT AND METHODS: A qualitative study of adults aged ≥ 25yrs (n = 31) of Ghanaian ancestry living in Greater Manchester using face to face interviews...
May 23, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28535183/time-caloric-restriction-inhibits-the-neoplastic-transformation-of-cirrhotic-liver-in-rats-treated-with-diethylnitrosamine
#14
Christian Molina-Aguilar, María de Jesús Guerrero-Carrillo, Jesús Javier Espinosa-Aguirre, Sitlali Olguin-Reyes, Thania Castro-Belio, Olivia Vázquez-Martínez, Julieta Berenice Rivera-Zavala, Mauricio Díaz-Muñoz
Hepatocellular cancer is the most common type of primary liver cancer. Cirrhosis is the main risk factor that generates this malady. It has been proven that caloric restriction protocols and restricted feeding schedules are protective in experimental carcinogenic models. We tested the influence of a time-caloric restriction protocol (2 h of food access during the daytime for 18 weeks) in an experimental model of cirrhosis-hepatocarcinoma produced by weekly administration of diethylnitrosamine. Our results indicate that time-caloric restriction reduced hepatomegaly and prevented the increase in blood leukocytes promoted by diethylnitrosamine...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28535176/invited-commentary-30-year-perspective-on-the-seven-countries-study
#15
Henry Blackburn
In a 1986 article (Am J Epidemiol. 1986;124(6):903-915), Keys et al. described and discussed 15-year findings from 15 cohorts of the Seven Countries Study (SCS), the first systematic study of diet, risk characteristics, disease-specific death rates, and their ecologic and individual associations both among and within whole populations of working men in regions with contrasting traditional diets. The SCS findings included 30-fold cohort differences in rates of death from coronary heart disease and 3-fold differences in rates of death from all causes, along with strong ecologic associations among diet, risk factors, and disease rates...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534060/food-swamps-by-area-socioeconomic-deprivation-in-new-zealand-a-national-study
#16
Zaynel Sushil, Stefanie Vandevijvere, Daniel J Exeter, Boyd Swinburn
OBJECTIVES: A nationwide spatial analysis of community retail food environments in relation to area socioeconomic deprivation was conducted in New Zealand. METHODS: Addresses from about 20,000 registered food outlets were retrieved from all 66 Councils. Outlets were classified, geocoded and (spatially) validated. The analysis included 4087 convenience, 4316 fast food/takeaway and 1271 supermarket and fruit/vegetable outlets and excluded outlets not considered 'healthy' or 'unhealthy'...
May 22, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28533753/age-related-assessment-of-sugar-and-protein-intake-of-ceratitis-capitata-in-ad-libitum-conditions-and-modeling-its-relation-to-reproduction
#17
Nikos A Kouloussis, Petros T Damos, Charalambos S Ioannou, Constantinos Tsitsoulas, Nikos T Papadopoulos, David Nestel, Dimitris S Koveos
In the inquiry on the age related dietary assessment of an organism, knowledge of the distributional patterns of food intake throughout the entire life span is very important, however, age related nutritional studies often lack robust feeding quantification methods due to their limitations in obtaining short-term food-intake measurements. In this study, we developed and standardized a capillary method allowing precise life-time measurements of food consumption by individual adult medflies, Ceratitis capitata (Diptera: Tephritidae), under laboratory conditions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28533568/leveraging-geotagged-twitter-data-to-examine-neighborhood-happiness-diet-and-physical-activity
#18
Quynh C Nguyen, Suraj Kath, Hsien-Wen Meng, Dapeng Li, Ken Robert Smith, James A VanDerslice, Ming Wen, Feifei Li
OBJECTIVES: Using publicly available, geotagged Twitter data, we created neighborhood indicators for happiness, food and physical activity for three large counties: Salt Lake, San Francisco and New York. METHODS: We utilize 2.8 million tweets collected between February-August 2015 in our analysis. Geo-coordinates of where tweets were sent allow us to spatially join them to 2010 census tract locations. We implemented quality control checks and tested associations between Twitter-derived variables and sociodemographic characteristics...
August 2016: Applied Geography
https://www.readbyqxmd.com/read/28533253/selexipag-for-the-treatment-of-pulmonary-arterial-hypertension
#19
Zachary R Noel, Kazuhiko Kido, Tracy E Macaulay
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, safety and tolerability, dosing and administration, and place in therapy of selexipag, an orally administered selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension (PAH), are reviewed. SUMMARY: The first-in-class oral prostacyclin IP receptor agonist selexipag (Uptravi, Actelion Pharmaceuticals) was approved by the Food and Drug Administration in December 2015...
May 22, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28532440/uptake-of-hiv-testing-in-burkina-faso-an-assessment-of-individual-and-community-level-determinants
#20
Fati Kirakoya-Samadoulougou, Kévin Jean, Mathieu Maheu-Giroux
BACKGROUND: Previous studies have highlighted a range of individual determinants associated with HIV testing but few have assessed the role of contextual factors. The objective of this paper is to examine the influence of both individual and community-level determinants of HIV testing uptake in Burkina Faso. METHODS: Using nationally representative cross-sectional data from the 2010 Demographic and Health Survey, the determinants of lifetime HIV testing were examined for sexually active women (n = 14,656) and men (n = 5680) using modified Poisson regression models...
May 22, 2017: BMC Public Health
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