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https://www.readbyqxmd.com/read/28927402/effects-of-premedication-with-oral-gabapentin-on-intraocular-pressure-changes-following-tracheal-intubation-in-clinically-normal-dogs
#1
Alexandra Trbolova, Masoud Selk Ghaffari, Igor Capik
BACKGROUND: Gabapentin is an antiepileptic drug widely approved as an add-on therapy for epilepsy treatment in human and dogs. There is a clinical impression that gabapentin is a suitable drug which attenuates the IOP elevation associated with tracheal intubation in humans. The present study performed to determine the effects of oral gabapentin on intraocular pressure (IOP) changes following tracheal intubation in dogs. RESULTS: Twenty adult healthy dogs were randomly assigned to treatment (n = 10) and control (n = 10) groups...
September 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28921309/lung-cancer-associated-brain-metastasis-molecular-mechanisms-and-therapeutic-options
#2
REVIEW
Meysam Yousefi, Tayyeb Bahrami, Arash Salmaninejad, Rahim Nosrati, Parisa Ghaffari, Seyed H Ghaffari
BACKGROUND: Lung cancer is the most common cause of cancer-related mortality in humans. There are several reasons for this high rate of mortality, including metastasis to several organs, especially the brain. In fact, lung cancer is responsible for approximately 50% of all brain metastases, which are very difficult to manage. Understanding the cellular and molecular mechanisms underlying lung cancer-associated brain metastasis brings up novel therapeutic promises with the hope to ameliorate the severity of the disease...
September 18, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28916186/clinical-immunological-and-genetic-spectrum-of-696-patients-with-combined-immunode%C3%AF-ciency
#3
Hassan Abolhassani, Janet Chou, Wayne Bainter, Craig Platt, Mahmood Tavassoli, Toba Momen, Marzieh Tavakol, Mohammad Hossein Eslamian, Mohammad Gharagozlou, Masoud Movahedi, Mohsen Ghadami, Amir Ali Hamidieh, Gholamreza Azizi, Reza Yazdani, Mohsen Afarideh, Alireza Ghajar, Arash Havaei, Zahra Chavoushzadeh, Seyed Alireza Mahdaviani, Taher Cheraghi, Nasrin Behniafard, Reza Amin, Soheila Aleyasin, Reza Faridhosseini, Farahzad Jabbari-Azad, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Mahboubeh Mansouri, Mehrnaz Mesdaghi, Delara Babaie, Iraj Mohammadzadeh, Javad Ghaffari, Alireza Shafiei, Najmeddin Kalantari, Hamid Ahanchian, Maryam Khoshkhui, Habib Soheili, Abbas Dabbaghzadeh, Afshin Shirkani, Rasoul Nasiri Kalmarzi, Seyed Hamidreza Mortazavi, Javad Tafaroji, Abbas Khalili, Javad Mohammadi, Babak Negahdari, Mohammad-Taghi Joghataei, Basel K Al-Ramadi, Capucine Picard, Nima Parvaneh, Nima Rezaei, Talal Chatila, Michel J Massaad, Sevgi Keles, Lennart Hammarström, Raif S Geha, Asghar Aghamohammadi
BACKGROUND: Combined immunodeficiencies (CIDs) are diseases of defective adaptive immunity with diverse clinical phenotypes. Although CIDs are more prevalent in the Middle East than Western countries, the resources for genetic diagnosis are limited. OBJECTIVES: This study aims to characterize the categories of CID patients in Iran clinically and genetically. METHODS: Clinical and laboratory data were obtained from 696 patients with CIDs. Patients were subdivided into those with syndromic (344 patients) and non-syndromic CIDs (352 patients)...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28875004/a-comparative-cytotoxic-evaluation-of-disulfiram-encapsulated-plga-nanoparticles-on-mcf-7-cells
#4
Hamidreza Fasehee, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed-Hamidollah Ghaffari, Shahab Faghihi
Background: Disulfiram is oral aldehyde dehydrogenase (ALDH) inhibitor that has been used in the treatment of alcoholism. Recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. Encapsulation of disulfiram polymeric nanoparticles (NPs) may improve its anticancer activities and protect rapid degradation of the drug. Materials andMethods: A poly (lactide-co-Glycolide) (PLGA) was developed for encapsulation of disulfiram and its delivery into breast cancer cells...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28874216/nutrient-intake-rumen-fermentation-and-growth-performance-of-dairy-calves-fed-extruded-full-fat-soybean-as-a-replacement-for-soybean-meal
#5
A ZeidAli-Nejad, G R Ghorbani, S Kargar, A Sadeghi-Sefidmazgi, A Pezeshki, M H Ghaffari
The objective of this study was to investigate the effects of extruded full-fat soybean (ESB) as a replacement for soybean meal (SBM) on nutrient intake, rumen fermentation, and growth performance of dairy calves. A total of 45 male Holstein dairy calves (42.0±0.5 kg of BW) were randomly assigned to one of three experimental diets: (1) 0% ESB (Control): 35.3% SBM no ESB; (2) 25% ESB: 27.0% SBM+9.0% ESB; and (3) 50% ESB: 19.0% SBM+19.0% ESB. All calves were weaned on day 56 of age and remained in the study until day 70 of age...
September 6, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28874136/himme-using-genetic-patterns-as-a-proxy-for-genome-assembly-reliability-assessment
#6
Jordi Abante, Noushin Ghaffari, Charles D Johnson, Aniruddha Datta
BACKGROUND: The information content of genomes plays a crucial role in the existence and proper development of living organisms. Thus, tremendous effort has been dedicated to developing DNA sequencing technologies that provide a better understanding of the underlying mechanisms of cellular processes. Advances in the development of sequencing technology have made it possible to sequence genomes in a relatively fast and inexpensive way. However, as with any measurement technology, there is noise involved and this needs to be addressed to reach conclusions based on the resulting data...
September 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28869817/dna-hypermethylation-of-tumor-suppressor-genes-rassf6-and-rassf10-as-independent-prognostic-factors-in-adult-acute-lymphoblastic-leukemia
#7
Samareh Younesian, Sepideh Shahkarami, Parisa Ghaffari, Shaban Alizadeh, Roya Mehrasa, Ardeshir Ghavamzadeh, Seyed H Ghaffari
BACKGROUND: The Hypermethylation of Ras association domain family (RASSF) often plays a key role in malignant progression of solid tumors; however, their impact on the prognosis and survival of adult ALL patients remain elusive. METHODS: The frequency of the promoter methylation pattern of RASSF6 and RASSF10 were analyzed in the peripheral blood (PB) samples taken at the time of diagnosis of 45 ALL patients. The methylation-specific PCR (MSP) assay was used to detect the DNA methylation patterns...
August 30, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28865408/peptide-based-vaccines-derived-from-fc%C3%AE%C2%B5ri-beta-subunit-can-reduce-allergic-response-in-mice-model
#8
Ahad Zare, Ali Akbar Pourfathollah, Zahra Pourpak, Janos Szebeni, Seyed Mohammad Reza Ghaffari, Gholam Ali Kardar
Current therapeutic approaches in allergic diseases especially asthma generally focus on using immunological strategies. According to the importance of FceRI in controlling allergic response we used two extracellular regions of Fc epsilon receptor I (FceRI) beta subunit peptides to design two peptide-based vaccines. Probably these peptides vaccines by triggering the immune response to FceRI can reduce the allergic symptoms through blocking the IgE specific receptor. Two extracellular parts of FceRI beta subunit were made by peptide synthesizer and conjugated with keyhole limpet Hemocyanin...
August 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28858790/image-registration-based-on-low-rank-matrix-rank-regularized-ssd
#9
Aboozar Ghaffari, Emad Fatemizadeh
Similarity measure is a main core of image registration algorithms. Spatially varying intensity distortion is an important challenge which affects the performance of similarity measures. Correlation among pixels is the main characteristic of this distortion. Similarity measures such as sum-of-squareddifferences (SSD) and mutual information (MI) ignore this correlation; Hence, perfect registration cannot be achieved in the presence of this distortion. In this paper, we model this correlation with the aid of the low rank matrix theory...
August 25, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28855609/primary-patient-derived-lung-adenocarcinoma-cell-culture-challenges-the-association-of-cancer-stem-cells-with-epithelial-to-mesenchymal-transition
#10
Verena Tiran, Joerg Lindenmann, Luka Brcic, Ellen Heitzer, Stefanie Stanzer, Nassim Ghaffari Tabrizi-Wizsy, Elvira Stacher, Herbert Stoeger, Helmut H Popper, Marija Balic, Nadia Dandachi
The cancer stem cell (CSC) and epithelial-to-mesenchymal transition (EMT) models have been closely associated and used to describe both the formation of metastasis and therapy resistance. We established a primary lung cell culture from a patient in a clinically rare and unique situation of primary resistant disease. This culture consisted of two biologically profoundly distinct adenocarcinoma cell subpopulations, which differed phenotypically and genotypically. One subpopulation initiated and sustained in spheroid cell culture (LT22s) whereas the other subpopulation was only capable of growth and proliferation under adherent conditions (LT22a)...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853135/epidemiological-characteristics-and-trends-in-the-incidence-of-animal-bites-in-maku-county-islamic-republic-of-iran-2003-2012
#11
Seyed Morteza Shamshirgaran, Hamid Barzkar, Saber Ghaffari-Fam, Ahmad Kosha, Parvin Sarbakhsh, Pari Ghasemzadeh
This study examined the epidemiological characteristics and incidence over time of animal bites in Maku County. Data were obtained from health centre records of animal bites from 2003 to 2012. Information on demographic characteristics and bite-related factors were recorded. A total of 2232 people were bitten; the frequency of bites was highest among males (75.4%), rural residents (72.3%) and those < 20 years (47.3%). Most bites were to the legs and feet (65%) and dogs were responsible for 92% of bites. Over 25% of those bitten delayed seeking care for more than a day, particularly rural residents...
August 27, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28841229/effect-of-vitamin-d-in-the-prevention-of-myocardial-injury-following-elective-percutaneous-coronary-intervention-a-pilot-randomized-clinical-trial
#12
Naser Aslanabadi, Iraj Jafaripor, Selda Sadeghi, Hadi Hamishehkar, Samad Ghaffari, Mehdi Toluey, Hanieh Azizi, Taher Entezari-Maleki
Myocardial injury following elective percutaneous coronary intervention (PCI) occurs in about one-third of patients and is associated with mortality. Platelet aggregation, thrombosis formation, and inflammation are the main causes of cardiac injury during PCI. Vitamin D plays a key role in the cardiovascular system by exerting antiplatelet, anticoagulant, and anti-inflammatory properties. There is no published study that investigated the effect of vitamin D in the prevention of cardiac injury following elective PCI...
August 25, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28836978/diurnal-variation-of-nmr-based-blood-metabolites-in-calves-fed-a-high-plane-of-milk-replacer-a-pilot-study
#13
Morteza H Ghaffari, Jayden A R MacPherson, Harma Berends, Michael A Steele
BACKGROUND: Blood profiles have been used to monitor herd health status, diagnose disorders, and predict the risk of diseases in cattle and calves. Characterizing plasma metabolites in dairy calves could provide further insight into daily metabolic variations and the mechanisms that lead to metabolic diseases. In addition, by understanding physiological ranges of plasma metabolites relative to meal and the time of feeding in healthy animals, veterinarians can accurately diagnose abnormalities with a blood test...
August 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28836347/oral-health-education-and-promotion-programmes-meta-analysis-of-17-year-intervention
#14
REVIEW
M Ghaffari, S Rakhshanderou, A Ramezankhani, M Noroozi, B Armoon
OBJECTIVES: Oral Health Education and Promotion Interventions (OHEPIs) focus on improving knowledge, to adopt favourable oral health behaviours that can enhance oral health and clinical oral health. However, no meta-analyses exist that evaluate the effectiveness of OHEPI programmes. The aim of this meta-analysis was to determine the effectiveness of oral health education and promotion programmes. METHODS: The PubMed, EMBASE, Cochrane and ScienceDirect databases from years 2000 to 2016 were searched...
August 24, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28836174/higher-frequency-of-nocturnal-blood-pressure-dipping-but-not-heart-rate-dipping-in-inflammatory-bowel-disease
#15
Leili Pourafkari, Kourosh Masnadi-Shirazi, Mohammadreza Taban, Solmaz Mohammadi, Razieh Parizad, Samad Ghaffari, Arezou Tajlil, Mir Milad Pourmousavi Khoshknab, Nader D Nader
BACKGROUND: Masked hypertension (MHTN) and lack of nocturnal dipping in blood pressure (BP) have been linked to the state of inflammation. AIMS: We aimed to assess the frequency of nocturnal patterns of BP and heart rate (HR) in patients with IBD. METHODS: Sixty-three normotensive patients with confirmed IBD during remission and 63 healthy subjects were enrolled in a case-control study. All subjects were monitored for BP and HR over a period of 24 h under ambulatory setting...
August 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28834761/novel-pan-pi3k-inhibitor-induced-apoptosis-in-apl-cells-correlates-with-suppression-of-telomerase-an-emerging-mechanism-of-action-of-bkm120
#16
Davood Bashash, Mahda Delshad, Ava Safaroghli-Azar, Majid Safa, Majid Momeny, Seyed H Ghaffari
The intertwining between cancer pathogenesis and perturbation of multitude signaling pathways ushered the cancer therapeutic approaches into an unbounded route of targeted therapies. For the nonce and among the plethora of promising inhibitors, intense interest has focused on small molecules targeting different component of PI3K axis. Intrigued by the constant activation of PI3K in leukemia, this study aimed to investigate the effects of BKM120, as the excelled member of pan PI3K inhibitors, in a panel of hematologic malignant cell lines...
August 20, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28834249/are-educating-and-promoting-interventions-effective-in-oral-health-a-systematic-review
#17
REVIEW
M Ghaffari, S Rakhshanderou, A Ramezankhani, Yab Buunk-Werkhoven, M Noroozi, B Armoon
OBJECTIVE: It is estimated that about 20%-25% of the world's population are suffering from periodontal diseases or severe gum diseases. This requires appropriate interventions. For the development of effective and evidence-based programmes tailored to the target group, the aim of this review was to survey to the effectiveness of oral health education and promotion interventions in the relevant groups of people. METHODS: The electronic databases including PubMed, EMBASE, Web of science and Cochrane Library were searched for English language studies between 2010 and (January-December) 2016...
August 22, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28828027/psychological-features-of-takotsubo-cardiomyopathy-report-of-four-cases
#18
Yaser Jenab, Seyedeh Roghaieh Hashemi, Neda Ghaffari-Marandi, Hoda Zafarghandi, Nazila Shahmansouri
Takotsubo or stress-induced cardiomyopathy is a cardiomyopathy in which the patient has a sudden onset, reversible left ventricular systolic dysfunction without any significant coronary artery disease. Four women, who were at a mean age of 64 years and suffered from chest pain exacerbated by emotional stress, were admitted as cases of acute coronary syndrome and were completely evaluated through precise history taking, physical examination, and ECG. Coronary angiography or coronary multidetector computed tomography was used to exclude significant coronary artery disease...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28828013/retentive-strength-of-orthodontic-bands-cemented-with-amorphous-calcium-phosphate-modified-glass-ionomer-cement-an-in-vitro-study
#19
Farzin Heravi, Maryam Omidkhoda, Niloufar Koohestanian, Tabassom Hooshmand, Hossein Bagheri, Negin Ghaffari
OBJECTIVES: The aim of this study was to evaluate and compare the retentive strength of orthodontic bands cemented with amorphous calcium phosphate (ACP)-containing and conventional glass ionomer cements (GICs). MATERIALS AND METHODS: One-hundred-and-twenty mandibular third molars were embedded in acrylic resin blocks with the buccal surface of crowns perpendicular to the base of the mold. The teeth were randomly divided into four groups containing 30 teeth each...
January 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28817391/tacrolimus-eye-drops-as-adjunct-therapy-in-severe-corneal-endothelial-rejection-refractory-to-corticosteroids
#20
Reza Ghaffari, Hamed Ghassemi, Mehran Zarei-Ghanavati, Golshan Latifi, Shima Dehghani, Zeeshan Haq, Ali R Djalilian
PURPOSE: To evaluate the safety and efficacy of tacrolimus eye drops as adjunctive therapy in the treatment of severe corneal endothelial rejection after penetrating keratoplasty refractory to corticosteroids. METHODS: In this prospective interventional case series, 11 eyes of 11 patients assessed for severe corneal endothelial rejection, with an inadequate response to topical, local, and systemic corticosteroids, were treated with either 0.01% or 0.05% tacrolimus eye drops 4 times daily...
October 2017: Cornea
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