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https://www.readbyqxmd.com/read/28238932/mono-2-ethylhexyl-phthalate-induced-sertoli-cell-injury-stimulates-the-production-of-pro-inflammatory-cytokines-in-fisher-344-rats
#1
Angela R Stermer, Caitlin J Murphy, Rashin Ghaffari, Kristin R Di Bona, Jorine J Voss, John H Richburg
Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the peripubertal rat-specific infiltration of macrophages after MEHP exposure is due, in part, to an increase in SC-specific inflammatory cytokine expression. To rule out that GC apoptosis itself is responsible for macrophage recruitment, rats were exposed to a direct germ cell toxicant, methoxy acetic acid (MAA), but no infiltration of macrophages was observed...
February 23, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28237128/primary-immunodeficiency-diseases-in-northern-iran
#2
I Mohammadzadeh, B Moazzami, J Ghaffari, A Aghamohammadi, N Rezaei
INTRODUCTION: Primary immunodeficiency diseases (PID) are a heterogeneous group of inherited disorders, characterised by recurrent severe infections, autoimmunity and lymphoproliferation. Despite impressive progress in identification of novel PID, there is an unfortunate lack of awareness among physicians in identification of patients with PID, especially in non-capital cities of countries worldwide. RESULT: This study was performed in a single-centre paediatric hospital in Northern Iran during a 21-year period (1994-2015)...
February 22, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28237025/geometric-requirements-for-tectorial-membrane-traveling-waves-in-the-presence-of-cochlear-loads
#3
Jonathan B Sellon, Roozbeh Ghaffari, Dennis M Freeman
Recent studies suggest that wave motions of the tectorial membrane (TM) play a critical role in determining the frequency selectivity of hearing. However, frequency tuning is also thought to be limited by viscous loss in subtectorial fluid. Here, we analyze effects of this loss and other cochlear loads on TM traveling waves. Using a viscoelastic model, we demonstrate that hair bundle stiffness has little effect on TM traveling waves calculated with physiological parameters, that the limbal attachment can cause small (<20%) increases in TM wavelength, and that viscous loss in the subtectorial fluid can cause small (<20%) decreases in TM wave decay constants...
February 22, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28227877/a-wearable-computing-platform-for-developing-cloud-based-machine-learning-models-for-health-monitoring-applications
#4
Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari, Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari
Wearable sensors have the potential to enable clinical-grade ambulatory health monitoring outside the clinic. Technological advances have enabled development of devices that can measure vital signs with great precision and significant progress has been made towards extracting clinically meaningful information from these devices in research studies. However, translating measurement accuracies achieved in the controlled settings such as the lab and clinic to unconstrained environments such as the home remains a challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218039/demethylation-and-alterations-in-the-expression-level-of-the-cell-cycle-related-genes-as-possible-mechanisms-in-arsenic-trioxide-induced-cell-cycle-arrest-in-human-breast-cancer-cells
#5
Farima Moghaddaskho, Haniyeh Eyvani, Mohsen Ghadami, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
Arsenic trioxide (As2O3) has been used clinically as an anti-tumor agent. Its mechanisms are mostly considered to be the induction of apoptosis and cell cycle arrest. However, the detailed molecular mechanisms of its anti-cancer action through cell cycle arrest are poorly known. Furthermore, As2O3 has been shown to be a potential DNA methylation inhibitor, inducing DNA hypomethylation. We hypothesize that As2O3 may affect the expression of cell cycle regulatory genes by interfering with DNA methylation patterns...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28216654/performance-kinetic-and-biodegradation-pathway-evaluation-of-anaerobic-fixed-film-fixed-bed-reactor-in-removing-phthalic-acid-esters-from-wastewater
#6
Ehsan Ahmadi, Samira Yousefzadeh, Mohsen Ansari, Hamid Reza Ghaffari, Ali Azari, Mohammad Miri, Alireza Mesdaghinia, Ramin Nabizadeh, Babak Kakavandi, Peyman Ahmadi, Mojtaba Yegane Badi, Mitra Gholami, Kiomars Sharafi, Mostafa Karimaei, Mahboobeh Ghoochani, Masoud Binesh Brahmand, Seyed Mohsen Mohseni, Maryam Sarkhosh, Soheila Rezaei, Hosseinali Asgharnia, Emad Dehghanifard, Behdad Jafari, Alireza Mortezapour, Vahid Kazemi Moghaddam, Mohammad Molla Mahmoudi, Nader Taghipour
Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine disrupting effects on human health. Industrial wastewater has been reported as an important environment with high concentrations of PAEs. In the present study, four short-chain PAEs including diallyl phthalate (DAP), diethyl phthalate (DEP), dimethyl phthalate (DMP), and phthalic acid (PA) were selected as a substrate for anaerobic fixed film fixed bed reactor (AnFFFBR)...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178288/monitoring-gait-in-multiple-sclerosis-with-novel-wearable-motion-sensors
#7
Yaejin Moon, Ryan S McGinnis, Kirsten Seagers, Robert W Motl, Nirav Sheth, John A Wright, Roozbeh Ghaffari, Jacob J Sosnoff
BACKGROUND: Mobility impairment is common in people with multiple sclerosis (PwMS) and there is a need to assess mobility in remote settings. Here, we apply a novel wireless, skin-mounted, and conformal inertial sensor (BioStampRC, MC10 Inc.) to examine gait characteristics of PwMS under controlled conditions. We determine the accuracy and precision of BioStampRC in measuring gait kinematics by comparing to contemporary research-grade measurement devices. METHODS: A total of 45 PwMS, who presented with diverse walking impairment (Mild MS = 15, Moderate MS = 15, Severe MS = 15), and 15 healthy control subjects participated in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28164050/extraskeletal-mesenchymal-chondrosarcoma-of-shoulder-an-extremely-rare-case
#8
Salman Ghaffari, Ali Farsavian, Seyed Mohamad Mehdi Daneshpoor, Masoud Shayesteh Azar
INTRODUCTION: Extraskeletal chondrosarcoma (EMC) is a rare, aggressive neoplasm which has been seen in the soft tissue area. This soft tissue sarcoma is classified to myxoid and mesenchymal based on histologic criteria. The mesenchymal subtype has a poor prognosis. In approximately 50% of patient with EMC, we could observe soft tissue lesion and stippled calcification in the conventional radiography. CASE REPORT: In the current paper, we introduced a 47-year-old Iranian male patient having painless, mobile, nontender, and firm mass in left shoulder...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28161222/fast-for-blunt-abdominal-trauma-correlation-between-positive-findings-and-admission-acid-base-measurement
#9
Kamran Heidari, Mehrdad Taghizadeh, Sadrollah Mahmoudi, Hamidreza Panahi, Ensieh Ghaffari Shad, Shadi Asadollahi
PURPOSE: This study aimed to determine any association between positive findings in ultrasonography examination and initial BD value with regard to diagnosis of intra-abdominal bleeding following blunt abdominal trauma. METHODS: A prospective, multi-center study of consecutive adult patients was performed from April to September 2015. Demographics, initial vital signs and arterial BD were evaluated with respect to presence of any association with intra-abdominal bleeding and in-hospital mortality...
January 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28135646/gap-free-segmentation-of-vascular-networks-with-automatic-image-processing-pipeline
#10
Chih-Yang Hsu, Mahsa Ghaffari, Ali Alaraj, Michael Flannery, Xiaohong Joe Zhou, Andreas Linninger
Current image processing techniques capture large vessels reliably but often fail to preserve connectivity in bifurcations and small vessels. Imaging artifacts and noise can create gaps and discontinuity of intensity that hinders segmentation of vascular trees. However, topological analysis of vascular trees require proper connectivity without gaps, loops or dangling segments. Proper tree connectivity is also important for high quality rendering of surface meshes for scientific visualization or 3D printing...
March 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28125433/pi3k-%C3%AE-inhibition-using-cal-101-exerts-apoptotic-effects-and-increases-doxorubicin-induced-cell-death-in-pre-b-acute-lymphoblastic-leukemia-cells
#11
Ava Safaroghli-Azar, Davood Bashash, Parisa Sadreazami, Majid Momeny, Seyed H Ghaffari
The frequency of dysregulated PI3K in acute lymphoblastic leukemia (ALL) coupled with the critical role of this signaling pathway in the acquisition of chemoresistant phenotype lend compelling weight to the application of PI3K inhibitors for the treatment of ALL. In this study, we found that abrogation of the PI3K pathway using CAL-101, a selective inhibitor of PI3K p110-δ, exerts a cytotoxic effect against Nalm-6 pre-B-ALL cells. Our results showed that the growth-suppressive effect is mediated, at least partially, by G1 arrest as a result of upregulated p21...
January 25, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28116268/pseudoaneurysm-of-the-posterior-tibial-artery-following-removal-of-tibial-plate-a-rare-case
#12
Salman Ghaffari, Hossein Farsavian, Seyed Mohamad Mehdi Daneshpoor, Masoud Shayesteh
INTRODUCTION: Pseudoaneurysm is a rare complication reported after any surgery such as ORIF of fracture, plate removal, ankle or knee arthroscopy or arthroplasty. To our knowledge, pseudoaneurysms of the posterior tibial artery after tibial plate removal are a rare phenomenon. We report a case of a 18-year-old male patient who had pseudoaneurysm of posterior tibial artery following plate removal. CASE PRESENTATION: A 18-year-old male was referred to our outpatient clinic because of mass-like lesion in his left calf...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28107693/attrition-among-iranian-nursing-students-a-qualitative-study
#13
Mansoureh Ashghali Farahani, Fatemeh Ghaffari, Fatemeh Oskouie, Mansoureh Zagheri Tafreshi
Attrition is a major challenge facing nursing students that results in substantial costs on the education, health, and treatment systems across countries and can have an unwanted effect on the quality and quantity of health services provided as well as on the health of citizens. This descriptive study investigated nursing students' perceptions toward factors influencing attrition. We conducted a qualitative study using a content analysis approach. Nineteen students enrolled in nursing bachelor program were recruited using purposive and snowball sampling...
January 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28104557/a-comparative-study-on-capability-of-different-tree-species-in-accumulating-heavy-metals-from-soil-and-ambient-air
#14
Ahmad Alahabadi, Mohammad Hassan Ehrampoush, Mohammad Miri, Hamideh Ebrahimi Aval, Samira Yousefzadeh, Hamid Reza Ghaffari, Ehsan Ahmadi, Parvaneh Talebi, Zeynab Abaszadeh Fathabadi, Fatemeh Babai, Ali Nikoonahad, Kiomars Sharafi, Ahmad Hosseini-Bandegharaei
Heavy metals (HMs) in the urban environment can be bio-accumulated by plant tissues. The aim of this study was to compare fourteen different tree species in terms of their capability to accumulate four airborne and soilborne HMs including; zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd). Samplings were performed during spring, summer, and fall seasons. To compare bioaccumulation ability, bio-concentration factor (BCF), comprehensive bio-concentration index (CBCI), and metal accumulation index (MAI) were applied...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28096480/chronic-tophaceous-gout
#15
Mahmoud Jabalameli, Abolfazl Bagherifard, Hosseinali Hadi, Vahid Behshad, Salman Ghaffari
No abstract text is available yet for this article.
January 17, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28074878/microscopic-evolution-of-laboratory-volcanic-hybrid-earthquakes
#16
H O Ghaffari, W A Griffith, P M Benson
Characterizing the interaction between fluids and microscopic defects is one of the long-standing challenges in understanding a broad range of cracking processes, in part because they are so difficult to study experimentally. We address this issue by reexamining records of emitted acoustic phonon events during rock mechanics experiments under wet and dry conditions. The frequency spectrum of these events provides direct information regarding the state of the system. Such events are typically subdivided into high frequency (HF) and low frequency (LF) events, whereas intermediate "Hybrid" events, have HF onsets followed by LF ringing...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070261/the-effect-of-utilizing-organizational-culture-improvement-model-of-patient-education-on-coronary-artery-bypass-graft-patients-anxiety-and-satisfaction-theory-testing
#17
Mansoureh Ashghali Farahani, Fatemeh Ghaffari, Faezeh Norouzinezhad, Roohangiz Jamshidi Orak
INTRODUCTION: Due to the increasing prevalence of arteriosclerosis and the mortality caused by this disease, Coronary Artery Bypass Graft (CABG) has become one of the most common surgical procedures. Utilization of patient education is approved as an effective solution for increasing patient survival and outcomes of treatment. However, failure to consider different aspects of patient education has turned this goal into an unattainable one. The objective of this research was to determine the effect of utilizing the organizational culture improvement model of patient education on CABG patients' anxiety and satisfaction...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28069896/anti-tumor-effects-of-shikonin-derivatives-on-human-medullary-thyroid-carcinoma-cells
#18
Carina Hasenoehrl, Gert Schwach, Nassim Ghaffari-Tabrizi-Wizsy, Robert Fuchs, Nadine Kretschmer, Rudolf Bauer, Roswitha Pfragner
New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radio- and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Onosma paniculata containing several shikonin derivatives. The unsubstituted shikonin derivative was found to be the most effective compound with an IC50 of 1...
January 9, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28054503/inhibition-of-telomerase-using-bibr1532-enhances-doxorubicin-induced-apoptosis-in-pre-b-acute-lymphoblastic-leukemia-cells
#19
Davood Bashash, Mohadeseh Zareii, Ava Safaroghli-Azar, Mir Davood Omrani, Seyed H Ghaffari
OBJECTIVES: Interest into targeting telomerase in cancer has increased by the recent disclosure that elevated telomerase activity is associated with disease recurrence and poor outcome in cancers. In addition, cellular acquisition of unlimited replicative potential, which is closely related to the maintenance of telomeres mostly via the reactivation of telomerase, has been shown to confer loss of sensitivity to a wide range of anti-neoplastic agents. METHODS: To evaluate whether telomerase inhibition using non-nucleosidic inhibitor of telomerase BIBR1532 could enhance cytotoxic effect of doxorubicin in acute lymphoblastic leukemia, Nalm-6 pre-B ALL cells were subjected to combination treatment and subsequent cell viability, growth kinetics, caspase-3 activity, and transcriptional alteration of p73, p21, FOXO3a, c-Myc, hTERT, and other apoptosis-related target genes were investigated...
January 5, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28052203/dietary-n-6-n-3-fatty-acid-ratios-alter-rumen-fermentation-parameters-and-microbial-populations-in-goats
#20
Mahdi Ebrahimi, Mohamed Ali Rajion, Kazeem Dauda Adeyemi, Saeid Jafari, Mohammad Faseleh Jahromi, Ehsan Oskoueian, Goh Yong Meng, Morteza Hosseini Ghaffari
Revealing the ruminal fermentation patterns and microbial populations as affected by dietary n-6:n-3 PUFA ratio would be useful for further clarifying the role of the rumen in the lipid metabolism of ruminants. The objective of the present study was to investigate the effects of dietary n-6:n-3 PUFA ratios on fermentation characteristics, fatty acid (FA) profiles, and microbial populations in the rumen of goats. A total of twenty-one goats were randomly assigned to three dietary treatments with different n-6:n-3 PUFA ratios of 2...
February 1, 2017: Journal of Agricultural and Food Chemistry
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