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Davood Azadi, Tahereh Motallebirad, Kazem Ghaffari, Hasan Shojaei
Background: Tuberculosis is one of the most important infectious diseases that has claimed its victims throughout much of known human history. With Koch's discovery of the tubercle bacillus as the etiologic agent of the disease, his sanitary and hygienic measures, which were based on his discovery and the development of a vaccine against tuberculosis by Albert Calmette and Camille Guérin in 1921, an attenuated Mycobacterium bovis strain, bacilli Calmette-Guérin (BCG), and the discovery of the first antibiotic against tuberculosis, streptomycin by Selman Waksman in 1943, soon led to the opinion that appropriate control measures had become available for tuberculosis and it had been assumed that the disease could ultimately be eradicated...
2018: Open Microbiology Journal
Vijay Menon, Saghi Ghaffari
PURPOSE OF REVIEW: Work in the past decade has revealed key functions of the evolutionary conserved transcription factors Forkhead box O (FOXO) in the maintenance of homeostatic hematopoiesis. Here the diverse array of FOXO functions in normal and diseased hematopoietic stem and progenitor cells is reviewed and the main findings in the past decade are highlighted. Future work should reveal FOXO-regulated networks whose alterations contribute to hematological disorders. RECENT FINDINGS: Recent studies have identified unanticipated FOXO functions in hematopoiesis including in hematopoietic stem and progenitor cells (HSPC), erythroid cells, and immune cells...
May 17, 2018: Current Opinion in Hematology
Roujin Ghaffari, Niloofar Eslahi, Elnaz Tamjid, Abdolreza Arash Simchi
Novel hydrogel nanoparticles with dual triggerable release properties based on fibrous structural proteins (Keratin) and thermoresponsive copolymers (Pluronic) is introduced. The nanoparticle was used for Curcumin delivery, as an effective and safe anticancer agent, hydrophobicity of which has limited its clinical application. The drug was loaded into hydrogel nanoparticles by a single-step nanoprecipitation method. The drug-loaded nanoparticles had an average dimeter of 165 nm and 66 nm at 25ºC and 37ºC, respectively...
May 17, 2018: ACS Applied Materials & Interfaces
Elmira Ebrahimi, Amir Almasi-Hashiani, Kimia Ghaffari, Reza Shirkoohi
Increase in the copy number of ERBB2 , a Tyrosine Kinase Receptor (TKR) leads to the overexpression of oncogene product and consequently uncontrolled cell proliferation which has been reported in different aggressive cancers with mitochondrial malfunctions. Although, amplification of ERBB2 has been reported in different studies; however, the association between changes in mitochondrial DNA content and the ERBB2 gene copy number is poorly understood. The relative mitochondrial DNA content of breast cancer tumor tissues of 70 patients who were referred to Imam Khomeini Hospital Complex was determined using quantitative Real-time PCR...
2018: EXCLI Journal
Jorine J L P Voss, Angela R Stermer, Rashin Ghaffari, Richa Tiwary, John Henry Richburg
The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to an accumulation of CD11b+ immune cells in the testicular interstitial space that closely correlates with a robust incidence of germ cell (GC) apoptosis. Here we test the hypothesis that the infiltrating immune cells contribute to GC apoptosis. Postnatal day 28 Fischer rats that received an oral dose of 700 mg/kg MEHP showed a significant infiltration of both CD11bc+/CD68+/CD163- macrophages and neutrophils...
May 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Kais Belwafi, Olivier Romain, Sofien Gannouni, Fakhreddine Ghaffari, Ridha Djemal, Bouraoui Ouni
BACKGROUND: Brain-computer interface (BCI) is a new communication pathway for users with neurological deficiencies. The implementation of a BCI system requires complex electroencephalography (EEG) signal processing including filtering, feature extraction and classification algorithms. Most of current BCI systems are implemented on personal computers. Therefore, there is a great interest in implementing BCI on embedded platforms to meet system specifications in terms of time response, cost effectiveness, power consumption, and accuracy...
May 5, 2018: Journal of Neuroscience Methods
Narges Kalantari, Salman Ghaffari, Masomeh Bayani
Background: Cryptosporidiosis is an important cause of diarrhea in children and immunosuppressive patients. The current study was intended to evaluate the prevalence rate of Cryptosporidium infection and clarify the epidemiological characteristics of the infection in both children and immunosuppressive patients in Iran. Methods: Five English electronic databases including PubMed, Google Scholar, Science Direct, Scopus and Cochrane, and two Persian language databases Magiran and Scientific Information Database were searched...
2018: Caspian Journal of Internal Medicine
Mohtasham Ghaffari, Bahram Armoon, Sakineh Rakhshanderou, Yadollah Mehrabi, Hamid Soori, Ozelem Simsekoghlu, Javad Harooni
INTRODUCTION: The use of seat belts could prevent severe collision damage to people in vehicle accidents and keep passengers safe from sustaining serious injuries; for instance, it could prevent passengers from being thrown out of a vehicle after the collision. The current systematic review will identify and analyse the determinants of seat belt use behaviour. METHODS AND ANALYSIS: We will include qualitative, quantitative and mixed methods studies reporting the acquired data from passengers aged more than 12 years and drivers, from both commercial and personal vehicles...
May 3, 2018: BMJ Open
Zeinab Latifi, Amir Fattahi, Kobra Hamdi, Aliye Ghasemzadeh, Pouran Karimi, Hamid Reza Nejabati, Marefat Ghaffari Novin, Leila Roshangar, Mohammad Nouri
Introduction: The importance of seminal vesicle secretion and uterine Wnt signaling for uterus preparation and embryo implantation has been described. Materials and Methods: In this study, we evaluated the gene expression of Wnt ligands (Wnt4 and Wnt5a) and their corresponding receptors (Fzd2 and Fzd6) using qRT-PCR and active β-catenin protein levels using western blotting in the uterine tissue of female mice mated with intact and seminal vesicle-excised (SVX) males during the pre-implantation window...
April 2018: Geburtshilfe und Frauenheilkunde
Ailar Nakhlband, Morteza Eskandani, Yadollah Omidi, Nazli Saeedi, Samad Ghaffari, Jaleh Barar, Alireza Garjani
Introduction: Cardiovascular diseases (CVDs) is recognized as the leading cause of mortality worldwide. The increasing prevalence of such disease demands novel therapeutic and diagnostic approaches to overcome associated clinical/social issues. Recent advances in nanotechnology and biological sciences have provided intriguing insights to employ targeted Nanomachines to the desired location as imaging, diagnosis, and therapeutic modalities. Nanomedicines as novel tools for enhanced drug delivery, imaging, and diagnosis strategies have shown great promise to combat cardiovascular diseases...
2018: BioImpacts: BI
Yaseen Rashidi, Hesam Manaflouyan, Fatemeh Pournaghi Azar, Zeinab Nikniaz, Leila Nikniaz, Samad Ghaffari
Introduction: This study aimed at evaluating knowledge and awareness of hypertension and the risk factors for hypertension among hypertensive patients. Methods: In this study, 110 hypertensive patients were enrolled and filled out two self-administered questionnaires. The first questionnaire was about the demographic characteristics and the second one was about the knowledge (n = 10), attitude (n = 9) and practice (n = 8). The internal consistency and the stability of the questionnaires were approved. The Mann-Whitney U test and Kruskal-Wallis and Spearman correlation coefficient were used for statistical analysis...
2018: Journal of Cardiovascular and Thoracic Research
Zohreh Ghorbani, Seyed Morteza Shamshirgaran, Samad Ghaffari, Parvin Sarbakhsh, Farzad Najafipour, Nayyereh Aminisani
BACKGROUND AND OBJECTIVE: There is remarkable alteration in hypertension prevalence and awareness, and their correlates among various geographic locations and ethnic groups. The aim of this study was to report hypertension prevalence, awareness, and its correlates as well as hypertension treatment, and control among Azari people aged 35 years and older. MATERIALS AND METHODS: The pilot phase of the Azar Cohort Study; a state level of a nationwide PERSIAN cohort study was conducted in Khameneh city between October 2014 and January 2015...
2018: Journal of Education and Health Promotion
Zahra Ghaffari, Mehdi Rahimmalek, Mohammad R Sabzalian
Essential oil (EO) composition, phenolic content, and antioxidant activity were investigated in 17 P. abrotanoides populations collected from different geographical regions in Iran. The highest (3.61%) and lowest (1.25%) essential oil yields were measured in populations from Semnan Province (PSESM2 ) and PISKS from Isfahan Province, respectively. GC-MS analysis identified camphor (4.05-35.94%), 1,8-cineole (7.15-24.34%), borneol (0-21.75%), and α-pinene (2.05-10.33%) as the main constituents of Perovskia essential oil...
April 23, 2018: Chemistry & Biodiversity
Elham Mousavinejad, Mohammad Ali Ghaffari, Forough Riahi, Maryam Hajmohammadi, Zeinab Tiznobeyk, Masoumeh Mousavinejad
Antioxidants and oxidative stress can participate in pathobiochemical mechanisms of autism spectrum disorders (ASDs). The aim was to identify the effects of early CoQ10 supplementation on oxidative stress in children with ASDs. Ninety children with ASDs were included in this study, based on DSM-IV criteria and using Childhood Autism Rating Scale (CARS) scores. Concentrations of CoQ10 , MDA, total antioxidant status (TAS) assay, and antioxidant enzymes (superoxide dismutase or SOD and glutathione peroxidase or GPx) activity were determined in serum before and after 100 days of supportive therapy with CoQ10 at daily doses of 30 and 60 mg...
April 4, 2018: Psychiatry Research
Leili Pourafkari, Aidin Baghbani-Oskouei, Mehrnoush Toufan, Samad Ghaffari, Nader D Nader
Hypoplasia of the mitral leaflets is rarely reported in adults. We reported a 45-year-old man presented to us with palpitation, dyspnea, and severe mitral regurgitation. In echocardiographic examination, an immobile hypoplastic posterior mitral leaflet (PML) was detected. A review of clinical and echocardiographic findings of all reported cases revealed that mitral regurgitation was the most common finding associated with PML hypoplasia/uni-leaflet mitral valve. PML hypoplasia is rare and often an incidental diagnosis during echocardiography, which could be relatively well tolerated since adulthood and carries a good prognosis...
April 20, 2018: Echocardiography
Ahmad Separham, Bahram Sohrabi, Arezou Tajlil, Leili Pourafkari, Robabeh Sadeghi, Samad Ghaffari, Nader D Nader
BACKGROUND: Lead aVR provides prognostic information in various settings in patients with ischemia. We aim to investigate the role of a positive T wave in lead aVR in non-ST segment myocardial infarction (NSTEMI). METHODS: In a prospective cohort study, we included 400 patients with NSTEMI. Presentation electrocardiogram (ECG) was investigated for presence of a positive T wave as well as ST segment elevation (STE) in aVR and study variables were compared. Predictors of primary outcome defined as hospital major adverse cardiovascular events (MACE) and secondary outcome, defined as three-vessel coronary disease and/or left main coronary artery stenosis (3VD/LMCA) stenosis in angiography, were determined in multivariate logistic regression analysis...
April 19, 2018: Annals of Noninvasive Electrocardiology
Amaneh Mahmoudian, Razieh Torabi Chafjiri, Atefeh Alipour, Abbas Shamsalinia, Fatemeh Ghaffari
Introduction: Older adults with chronic disease are more vulnerable to abuse. Early and accurate detection of the elderly abuse phenomenon can help identify health-promoting solutions for the elderly, their family, and society. The purpose of this study was to design and evaluate the psychometric properties of a questionnaire on elderly abuse by family caregivers among older adults on hemodialysis. Methods: Qualitative and quantitative research methodologies were used to develop the questionnaire...
2018: Clinical Interventions in Aging
Marjan Rabani-Bavojdan, Mozhgan Rabani-Bavojdan, Ghodratollah Rajabizadeh, Nahid Kaviani, Ali Bahramnejad, Zohreh Ghaffari, Mehdi Shafiei-Bafti
Background: The aim of this study was to investigate the effectiveness of the harm reduction group therapy based on Bandura's self-efficacy theory on risky behaviors of sex workers in Kerman, Iran. Methods: A quasi-experimental two-group design (a random selection with pre-test and post-test) was used. A risky behaviors questionnaire was used to collect. The sample was selected among sex workers referring to drop-in centers in Kerman. Subjects were allocated to two groups and were randomly classified into two experimental and control groups...
July 2017: Addiction & Health
H Omidi-Mirzaei, A Azarfar, A Kiani, M Mirzaei, M H Ghaffari
The objective of this study was to investigate the effects of the physical forms of starter and forage sources on feed intake, growth performance, rumen pH, and blood metabolites of dairy calves. Forty male Holstein calves (41.3 ± 3.5 kg of body weight) were used (n = 10 calves per treatment) in a 2 × 2 factorial arrangement of treatments with the factors being physical forms of starter (coarse mash and texturized) and forage source [alfalfa hay (AH) and wheat straw (WS)]. Individually housed calves were randomly assigned to 1 of the 4 dietary treatments, including (1) coarsely mashed (CM; coarse ground grains combined with a mash supplement) starter feed with AH (CM-AH), (2) coarsely mashed starter feed with WS (CM-WS), (3) texturized feed starter (TF; includes steam-flaked corn, steam-rolled barley combined with a pelleted supplement) with AH (TF-AH), and (4) TF with WS (TF-WS)...
April 11, 2018: Journal of Dairy Science
Guy R Adami, Christy C Tangney, Jessica L Tang, Yalu Zhou, Saba Ghaffari, Ankur Naqib, Saurabh Sinha, Stefan J Green, Joel L Schwartz
Consumption of green tea (GT) extracts or purified catechins has shown the ability to prevent oral and other cancers and inhibit cancer progression in rodent models, but the evidence for this in humans is mixed. Working with humans, we sought to understand the source of variable responses to GT by examining its effects on oral epithelium. Lingual epithelial RNA and lingual and gingival microbiota were measured before and after 4 weeks of exposure in tobacco smokers, whom are at high risk of oral cancer. GT consumption had on average inconsistent effects on miRNA expression in the oral epithelium...
April 12, 2018: Scientific Reports
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