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https://www.readbyqxmd.com/read/29141792/cd25-gene-polymorphism-and-multiple-sclerosis
#1
EDITORIAL
Fereshteh Alsahebfosoul, Rasoul Salehi, Sara Ghaffari, Hamidreza Jahanbani-Ardakani, Masoud Etemadifar, Mohammad Kazemi, Seyed-Hossein Abtahi
No abstract text is available yet for this article.
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29128812/pharmacological-evidence-for-the-involvement-of-adenosine-triphosphate-sensitive-potassium-channels-in-chloroquine-induced-itch-in-mice
#2
Sattar Ostadhadi, Arash Foroutan, Nazgol-Sadat Haddadi, Abbas Norouzi-Javidan, Majid Momeny, Ghazaleh Zarrinrad, Seyed Hamid Ghaffari, Ahmad-Reza Dehpour
BACKGROUND: Chloroquine (CQ) evokes itch in human and scratching behavior in rodents through a histamine-independent pathway. Chloroquine directly excites peripheral sensory neurons which convey itch signals to the central nervous system. It has been revealed that ATP-sensitive potassium channels (KATP channels) are important in regulating neuronal excitability. Thus, we aimed to investigate the involvement of KATP channels in CQ-induced itch which may also reveal a linkage between metabolic state of cells and itch...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29126049/large-scale-subject-specific-cerebral-arterial-tree-modeling-using-automated-parametric-mesh-generation-for-blood-flow-simulation
#3
Mahsa Ghaffari, Kevin Tangen, Ali Alaraj, Xinjian Du, Fady T Charbel, Andreas A Linninger
In this paper, we present a novel technique for automatic parametric mesh generation of subject-specific cerebral arterial trees. This technique generates high-quality and anatomically accurate computational meshes for fast blood flow simulations extending the scope of 3D vascular modeling to a large portion of cerebral arterial trees. For this purpose, a parametric meshing procedure was developed to automatically decompose the vascular skeleton, extract geometric features and generate hexahedral meshes using a body-fitted coordinate system that optimally follows the vascular network topology...
October 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29122251/the-effect-of-acupressure-on-pain-anxiety-and-the-physiological-indexes-of-patients-with-cancer-undergoing-bone-marrow-biopsy
#4
Moloud Sharifi Rizi, Abbas Shamsalinia, Fatemeh Ghaffari, Shahrbanoo Keyhanian, Bahram Naderi Nabi
OBJECTIVES: This study aimed to determine the effect of acupressure on pain intensity, anxiety, and physiological indexes of patients with cancer undergoing bone marrow biopsy and aspiration. METHODS: The study was designed as a randomized, double-blinded, controlled trial. Ninety samples was selected using the convenience sampling method, then for allocation groups random block sampling was used (30 for each group). The three groups were similar by age and gender...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29097735/mammalian-%C3%AE-2-ampk-regulates-intrinsic-heart-rate
#5
Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J Jung, Kirill V Tarasov, Emily J Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R St Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D Ziman, Jack M Moen, Daniel R Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G Matt, Yelena S Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M Siggs, John Gomes, Hannah Muskett, Mahon L Maguire, Youlia Beglov, Matthew Kelly, Pedro P N Dos Santos, Nicola J Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J P Ferguson, Jürgen E Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M Channon, Richard J Cornall, Eduardo B Sternick, David J Paterson, Charles S Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G Lakatta, Hugh Watkins, Houman Ashrafian
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemmal Ca(2+) release...
November 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/29082365/exposure-of-neonatal-mice-to-sevoflurane-may-induce-male-germ-cell-apoptosis-in-testicular-tissue-after-puberty
#6
Maryam Nezhad Sistani, Anahid Maleki, Maryam Salimi, Marefat Ghaffari Novin, Hamid Nazarian
BACKGROUND: common use of sevoflurane in congenital defects during repeated surgeries may have detrimental effects on spermatogenesis after puberty. OBJECTIVE: This study investigated sevoflurane effects on spermatogenesis process in male mature mice after exposure in prepubertal time. MATERIALS AND METHODS: 24 neonatal NMRI male mice were randomly classified in three groups. Experimental 1 and 2 groups (exposure to 1 minimum alveolar concentration (MAC) and 2 MAC sevoflurane, respectively in 2 lit/min oxygen (O2) for 7 days (30 min, daily) and control...
August 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29078275/motion-microscopy-for-visualizing-and-quantifying-small-motions
#7
Neal Wadhwa, Justin G Chen, Jonathan B Sellon, Donglai Wei, Michael Rubinstein, Roozbeh Ghaffari, Dennis M Freeman, Oral Büyüköztürk, Pai Wang, Sijie Sun, Sung Hoon Kang, Katia Bertoldi, Frédo Durand, William T Freeman
Although the human visual system is remarkable at perceiving and interpreting motions, it has limited sensitivity, and we cannot see motions that are smaller than some threshold. Although difficult to visualize, tiny motions below this threshold are important and can reveal physical mechanisms, or be precursors to large motions in the case of mechanical failure. Here, we present a "motion microscope," a computational tool that quantifies tiny motions in videos and then visualizes them by producing a new video in which the motions are made large enough to see...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29076562/a-systematic-review-of-empirical-studies-on-methodology-and-burden-of-informal-patient-payments-in-health-systems
#8
REVIEW
Abdolvahed Khodamoradi, Mohammad Payam Ghaffari, Reza Daryabeygi-Khotbehsara, Haniye Sadat Sajadi, Reza Majdzadeh
INTRODUCTION: Informal patients' payments (IPPs) is a sensitive subject. The aim of current study was to assess the trends in informal payment studies and explore methods of IPPs measurement, prevalence, and features (payment type, volume, and receiver) in various contexts. METHODS: A search strategy was developed to identify peer-reviewed articles addressing informal payments on PubMed, Science Direct, Web of Science, Scopus, and CINAHL. A total of 1252 studies were identified initially...
October 27, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29064011/using-the-theory-of-planned-behavior-framework-for-designing-interventions-related-to-organ-donation
#9
M Ghaffari, M Latifi, C A Rocheleau, K Najafizadeh, S Rakhshanderou, A Ramezankhani
No abstract text is available yet for this article.
October 24, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29063394/multivariate-curve-resolution-of-organic-pollution-patterns-in-mangrove-forest-sediment-from-qeshm-island-and-khamir-port-persian-gulf-iran
#10
Mahsa Dadashi, Sanaz Ghaffari, Alireza Riyahi Bakhtiari, Roma Tauler
Straight-chain alkanes (n-alkanes) have been proposed as biomarkers to assess petroleum pollution sources in marine environments. In this work, three sampling sites were selected along Iranian-protected mangrove forests in the Persian Gulf. Sample sites were chosen to represent different compositions and sources of n-alkanes in surface sediments (0-5 cm) from different locations in the Khamir Port, in the middle part of the Gulf, and in the Qeshm Island. Samples were analyzed by gas chromatography-mass spectrometry (GC-MS), and the obtained n-alkanes concentrations were analyzed by principal component analysis (PCA) and multivariate curve resolution alternating least squares (MCR-ALS) to deduce their possible sources and distribution patterns...
October 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29043284/exploring-the-position-of-community-based-nursing-in-iran-a-qualitative-study
#11
Heshmatolah Heydari, Zahra Rahnavard, Fatemeh Ghaffari
BACKGROUND: Community-based nursing focuses on providing health services to families and communities in the second and third levels of prevention and this can improve the individuals, families and communities' quality of life, and reduce the healthcare costs. The aim of this study was to explore the status of community-based nursing in Iran. METHODS: This qualitative study was conducted from March to November 2015, in Tehran, Iran, using the content analysis approach...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29038395/acute-interstitial-nephritis-induced-by-citrullus-colocynthis
#12
Shokoufeh Savaj, Mohammad Ghaffari, Mohammad Amin Abbasi, Javad Azar
Acute interstitial nephritis (AIN) is known as a common cause of acute kidney injury, found in 15% to 27% of kidney biopsies. Drug-induced AIN is currently the most common cause of AIN. The most common medications causing AIN are antibiotics and nonsteroidal anti-inflammatory drugs. We describe a case of Citrullus colocynthis (herbal remedy for diabetes mellitus and weight reduction) that induced AIN. A 31-year-old woman with major thalassemia, diabetes mellitus, and hepatitis C infection was admitted because of flank pain and unexpected increase in serum creatinine level...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29017374/prevalence-of-sexually-transmitted-infections-and-their-risk-factors-among-female-sex-workers-in-isfahan-iran-a-cross-sectional-study
#13
Maryam Nasirian, Sina Kianersi, Shervin Ghaffari Hoseini, Nazila Kassaian, Majid Yaran, Parisa Shoaei, Behrooz Ataei, Reza Fadaei, Marjan Meshkati, Alireza Emami Naeini, Mojtaba Rostami Jalilian
OBJECTIVES: Female sex workers (FSWs) are at high risk of sexually transmitted infections (STIs) and form a core group to facilitate STI spreading. We aimed to estimate the prevalence of STIs among FSWs who attended Female Harm Reduction Center of Isfahan, Iran, and to determine the association between risky behaviors and STIs. STUDY DESIGN: In a cross-sectional study, 99 FSWs were recruited and interviewed about demographic characteristics and risky behaviors. A trained midwife examined FSWs for genital ulcer, abnormal vaginal discharge, and cervicitis...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28990117/expression-of-matrix-metalloproteinase-12-is-highly-specific-for-non-proliferating-invasive-trophoblasts-in-the-first-trimester-and-temporally-regulated-by-oxygen-dependent-mechanisms-including-hif-1a
#14
Ursula Hiden, Christian P Eyth, Alejandro Majali-Martinez, Gernot Desoye, Carmen Tam-Amersdorfer, Berthold Huppertz, Nassim Ghaffari Tabrizi-Wizsy
During first trimester pregnancy, trophoblast cells invade from the placenta into the maternal decidua where they anchor the placenta and remodel luminal structures like spiral arteries. This process depends on proteases secreted by invading trophoblasts, which degrade extracellular matrix (ECM). We here aimed to identify proteases particularly important for trophoblast invasion. We generated a list of proteases capable of degrading decidual ECM and trophoblast integrins using MEROPS database and compared expression of these proteases between primary trophoblasts isolated from first trimester placenta (FT, n = 3), representing an invasive phenotype, vs trophoblasts isolated from term pregnancy (TT, n = 3), representing a non-invasive trophoblast phenotype...
October 9, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28989593/colorectal-cancer-screening-a-comprehensive-review-to-recent-non-invasive-methods
#15
REVIEW
Leila Hamzehzadeh, Meysam Yousefi, Seyed-Hamidollah Ghaffari
Colorectal cancer (CRC) is one of the most common cancers worldwide and considered to be one of the hassles in medical communities. CRC develops from precancerous polyps in the colon or rectum and is preventable and curable by an early diagnosis and with the removal of premalignant polyps. In recent years, scientists have looked for inexpensive and safe ways to detect CRC in its earliest stages. Strong evidence shows that screening for CRC is a crucial way to reduce the incidence and mortality of this devastating disease...
July 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28986387/determination-of-reference-values-for-intraocular-pressure-and-schirmer-tear-test-results-in-clinically-normal-domestic-donkeys-equus-asinus
#16
Masoud Selk Ghaffari, Amin Sabzevari, SeyedMehdi Ghamsari, Hussein Shad
This study was conducted to establish normal reference range for the Schirmer tear test (STT) and intraocular pressure (IOP) in clinically normal donkeys for use in clinical practice. Sixteen adult Ethiopian domestic donkeys were used in this study. Complete ophthalmic examinations were performed without chemical restraint. STT values were evaluated in both eyes of all donkeys using a commercial STT strip. IOP was measured in both eyes with a Tono-Pen Vet (Reichert. USA) without using regional nerve blocks...
October 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28986276/expression-and-localization-of-relaxin-family-peptide-receptor-4-in-human-spermatozoa-and-impact-of-insulin-like-peptide-5-on-sperm-functions
#17
Imaneh Shamayeli Yeganeh, Amir Hossein Taromchi, Fatemeh Fadaei Fathabadi, Reza Nejatbakhsh, Marefat Ghaffari Novin, Saeed Shokri
Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily peptide that interacts with the relaxin family peptide receptor 4 (RXFP4). Numerous recent studies have focused on the functional effects of INSL5 on fat and glucose metabolism. Although there is no evidence that the human sperm may be a candidate target of INSL5, it has been detected in mice testis and sperm. Therefore, the present study sought to analyze the localization and expression of RXFP4 on human sperm and determine the efficiency of INSL5 in human sperm...
October 4, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28986145/peptides-for-targeting-%C3%AE-b2-crystallin-fibrils
#18
Mehdi Ghaffari Sharaf, Sibel Cetinel, Valentyna Semenchenko, Karim F Damji, Larry D Unsworth, Carlo Montemagno
Crystallins are a major family of proteins located within the lens of the eye. Cataracts are thought to be due to the formation of insoluble fibrillar aggregates, which are largely composed of proteins from the crystallin family. Today the only cataract treatment that exists is surgery and this can be difficult to access for individuals in the developing world. Development of novel pharmacotherapeutic approaches for the treatment of cataract rests on the specific targeting of these structures. βB2-crystallin, a member of β-crystallin family, is a large component of the crystallin proteins within the lens, and as such was used to form model fibrils in vitro...
October 3, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28980195/air-pollution-and-admissions-due-to-st-elevation-myocardial-infarction-a-time-series-study-from-northwest-of-iran
#19
Samad Ghaffari, Reza Hajizadeh, Leili Pourafkari, Behrouz Shokouhi, Arezou Tajlil, Sarvin Mazani, Hadiseh Kavandi, Hosein Ansari, Nader D Nader
We investigated the association between the levels of air pollutants and the number of daily admissions due to ST segment elevation myocardial infarction (STEMI) in a metropolitan in the northwest of Iran. Daily concentrations of common air pollutants were obtained for the greater city of Tabriz for a period of 2 years. These reports included sulfur dioxide (SO2), nitrogen dioxide (NO2), nitric oxide (NO), nitrogen byproducts (NOx), carbon monoxide (CO), ozone (O3), and particulate matters < 10 μm (PM10)...
October 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28975536/asthma-disease-as-cause-of-admission-to-hospitals-due-to-exposure-to-ambient-oxidants-in-mashhad-iran
#20
Hamid Reza Ghaffari, Hamideh Ebrahimi Aval, Ahmad Alahabadi, Adel Mokammel, Ramzanali Khamirchi, Samira Yousefzadeh, Ehsan Ahmadi, Abolfazl Rahmani-Sani, Mehdi Estaji, Amin Ghanbarnejad, Abdolmajid Gholizadeh, Mahmoud Taghavi, Mohammad Miri
Nowadays, asthma is one of the most common chronic respiratory diseases, worldwide. Many reports have emphasized the correlation between the short-term exposure to the ambient air pollutants and acute respiratory diseases, especially among children with asthmatic symptoms. The aim of this study was to evaluate the relationship between the exposure to three atmospheric antioxidants (NO2, SO2, and O3) and hospital admission due to asthmatic disease (HAAD) in the city of Mashhad, Iran. The concentrations of atmospheric antioxidants were obtained from the real-time monitoring stations located in the city...
October 4, 2017: Environmental Science and Pollution Research International
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