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https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#1
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29770348/quantitative-live-cell-reporter-assay-for-noncanonical-wnt-activity
#2
Edith P Karuna, Michael W Susman, Hsin-Yi Henry Ho
Noncanonical Wnt signaling functions independently of the β-catenin pathway to control diverse developmental processes, and dysfunction of the pathway contributes to a number of human pathological conditions, including birth defects and metastatic cancer. Progress in the field, however, has been hampered by the scarcity of functional assays for measuring noncanonical Wnt signaling activity. We recently described the Wnt5a-Ror-Kif26b (WRK) reporter assay, which directly monitors a post-transcriptional regulatory event in noncanonical Wnt signaling...
March 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29768397/lipopolysaccharide-exposure-alleviates-asthma-in-mice-by-regulating-th1-th2-and-treg-th17-balance
#3
Fengxia Ding, Zhou Fu, Bo Liu
BACKGROUND It is generally believed that endotoxin exposure exacerbates risk of developing asthmatic symptoms. However, recent studies have indicated that prior bacterial exposure may prevent future symptoms of asthma. Here, we evaluated the influence of pre-exposure to different concentrations of lipopolysaccharide (LPS) to subsequent ovalbumin (OVA) allergen sensitization and challenge. MATERIAL AND METHODS Four-week-old Balb/c mice were treated intranasally with varying concentrations of LPS (1 ug, 10 ug, and 100 ug) or sterile PBS for 10 days, then 2 weeks later they were exposed to OVA...
May 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29765931/decreased-breg-th17-ratio-improved-the-prognosis-of-patients-with-ulcerative-colitis
#4
Xue Bing, Liang Linlang, Chen Keyan
Objective: To investigate the effects of regulatory B (Breg) cells and T helper 17 (Th17) cells on pathogenesis of ulcerative colitis, explore the clinical significance of Breg/Th17 ratio on the prognosis of ulcerative colitis, and provide the theoretical basis for the targeted therapy, diagnosis, and prognosis of the disease. Methods: Peripheral blood and colonic mucosa were collected from patients with ulcerative colitis. Hematoxylin-eosin staining was used to observe the pathological changes of colonic mucosa...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29762822/linc-ror-promotes-endometrial-cell-proliferation-by-activating-the-pi3k-akt-pathway
#5
X-Y Xu, J Zhang, Y-H Qi, M Kong, S-A Liu, J-J Hu
OBJECTIVE: To observe the expressions of Linc-ROR and proteins in the PI3K-Akt pathway in an ectopic lesion of adenomyosis. PATIENTS AND METHODS: The expression of Linc-ROR in the ectopic endometrium, eutopic endometrium, and normal endometrium of adenomyosis was detected by qRT-PCR. Western blot was used to detect the protein expressions of PI3K-Akt in endometriosis and lesion endometriosis. Cell counting kit-8 (CCK-8) assay was utilized to detect cell proliferative activity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29757590/imbalance-of-peripheral-blood-t-helper-type-17-responses-in-patients-with-vitiligo
#6
Farinaz Behfarjam, Parvine Mansouri, Zohreh Jadali
There is growing evidence to suggest that Th cells play pivotal roles in a variety of chronic inflammatory diseases, including vitiligo. However, the exact role of different subsets of Th cells in the pathogenesis of vitiligo is still a question. The purpose of present study was to determine the mRNA expression level of Th17 master transcription factor retinoic acid receptor-related orphan receptors gamma (RORɣt) and cytokine mRNA and protein expression profiles of Th17 cells. 22 patients with vitiligo and 22 normal subjects were enrolled in the study...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29750038/signals-of-bleeding-among-direct-acting-oral-anticoagulant-users-compared-to-those-among-warfarin-users-analyses-of-the-post-marketing-fda-adverse-event-reporting-system-faers-database-2010-2015
#7
Thamir M Alshammari, Sondus I Ata, Mansour Adam Mahmoud, Tariq M Alhawassi, Hisham S Aljadhey
Purpose: To analyze and compare the signals of bleeding from the use of direct-acting oral anticoagulants (DOACs) in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database over 5 years. Methods: Reports of bleeding and of events with related terms submitted to the FAERS between October 2010 and September 2015 were retrieved and then analyzed using the reporting odds ratio (ROR). The signals of bleeding associated with DOAC use were compared with the signals of bleeding associated with warfarin use utilizing the FAERS databases...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29746915/cognition-and-dementia-related-adverse-effects-with-sacubitril-valsartan-analysis-of-the-fda-adverse-event-report-system-database
#8
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
BACKGROUND: As neprilysin is involved in the degradation of amyloid-beta, there is concern the angiotensin-neprilysin inhibitor, sacubitril-valsartan, could increase the risk for dementia. METHODS: We analyzed adverse event cases submitted to the FDA adverse event report system between July 2015 and March 2017. Cognition and dementia related adverse event cases were defined using broad and narrow structured medical queries. RESULTS: During the period evaluated, 9,004 adverse event reports (out of a total of 2,249,479) involved the use of sacubitril-valsartan...
May 7, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29746914/cognition-and-dementia-related-adverse-effects-with-sacubitril-valsartan-analysis-of-the-fda-adverse-event-report-system-database
#9
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
BACKGROUND: As neprilysin is involved in the degradation of amyloid-beta, there is concern the angiotensin-neprilysin inhibitor, sacubitril-valsartan, could increase the risk for dementia. METHODS: We analyzed adverse event cases submitted to the FDA adverse event report system between July 2015 and March 2017. Cognition and dementia related adverse event cases were defined using broad and narrow structured medical queries. RESULTS: During the period evaluated, 9,004 adverse event reports (out of a total of 2,249,479) involved the use of sacubitril-valsartan...
May 7, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29743811/the-immunoregulation-of-th17-in-host-against-intracellular-bacterial-infection
#10
REVIEW
Yonghong Li, Chaojun Wei, Hui Xu, Jing Jia, Zhenhong Wei, Rui Guo, Yanjuan Jia, Yu Wu, Yuanting Li, Xiaoming Qi, Zhenhao Li, Xiaoling Gao
T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, ROR γ , and ROR α ), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF- β , IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17 plays a crucial role in host defense against a variety of pathogens, including bacteria and viruses. The underlying mechanisms by which Th17 performs include dendritic cell (DC) regulation, neutrophil recruitment, Th1 modulation, and T regulatory cell (Treg) balance...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29740327/extracellular-vesicles-as-carriers-of-non-coding-rnas-in-liver-diseases
#11
REVIEW
Junfa Yang, Changyao Li, Lei Zhang, Xiao Wang
Extracellular vesicles (EVs) are small membranous vesicles secreted from normal, diseased, and transformed cells in vitro and in vivo . EVs have been found to play a critical role in cell-to-cell communication by transferring non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long ncRNAs (lncRNAs) and so on. Emerging evidence shows that transferring biological information through EVs to neighboring cells in intercellular communication not only keep physiological functions, but also participate in the pathogenesis of liver diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29720397/increased-long-qt-and-torsade-de-pointes-reporting-on-tamoxifen-compared-with-aromatase-inhibitors
#12
Virginie Grouthier, Benedicte Lebrun-Vignes, Andrew M Glazer, Philippe Touraine, Christian Funck-Brentano, Antoine Pariente, Carine Courtillot, Anne Bachelot, Dan M Roden, Javid J Moslehi, Joe-Elie Salem
OBJECTIVE: A prolonged QTc (LQT) is a surrogate for the risk of torsade de pointes (TdP). QTc interval duration is influenced by sex hormones: oestradiol prolongs and testosterone shortens QTc. Drugs used in the treatment of breast cancer have divergent effects on hormonal status. METHODS: We performed a disproportionality analysis using the European database of suspected adverse drug reaction (ADR) reports to evaluate the reporting OR (ROR χ2 ) of LQT, TdP and ventricular arrhythmias associated with selective oestrogen receptor modulators (SERMs: tamoxifen and toremifene) as opposed to aromatase inhibitors (AIs: anastrozole, exemestane and letrozole)...
May 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29694511/long-non-coding-rna-ror-aggravates-myocardial-ischemia-reperfusion-injury
#13
Weiwei Zhang, Ying Li, Peng Wang
Long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of cardiovascular diseases, especially in myocardial infarction and ischemia/reperfusion (I/R). However, the underlying molecular mechanism remains unclear. In this study, we determined the role and the possible underlying molecular mechanism of lncRNA-ROR in myocardial I/R injury. H9c2 cells and human cardiomyocytes (HCM) were subjected to either hypoxia/reoxygenation (H/R), I/R or normal conditions (normoxia). The expression levels of lncRNA-ROR were detected in serum of myocardial I/R injury patients, H9c2 cells, and HCM by qRT-PCR...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29690669/-lincrna-ror-functions-as-a-cerna-to-regulate-oct4-sox2-and-nanog-expression-by-sponging-mir-145-and-its-effect-on-biologic-characteristics-of-colonic-cancer-stem-cells
#14
Z Y Yan, X C Sun
Objective: To investigate the impact of lincRNA-ROR, a ceRNA by binding miR-145 on the expression of the downstream genes Oct4, Sox2 and Nanog, and related biological characteristics of colon cancer stem cells, and to elucidate the clinical significance of this molecular regulatory network. Methods: Fifty-two cases of colorectal cancer tissue and adjacent tissue were collected at Nanyang City Central Hospital and Nanyang Second Hospital, Henan Province, from 2014 to 2016. Real-time quantitative polymerase chain reaction (qPCR) was used to detect the expression of lincRNA-ROR and miR-145 in colorectal cancer tissue and isolated colon cancer cells...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29686529/notch1-signaling-regulates-the-th17-treg-immune-imbalance-in-patients-with-psoriasis-vulgaris
#15
Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang
Purpose: To evaluate the regulating effect of Notch1 signaling on Th17/Treg immune imbalance in psoriasis vulgaris (PV). Materials and Methods: Notch1, Hes-1, ROR γ t, Foxp3, IL-17, and IL-10 mRNA expression, as well as Th17 and Treg cell percentages in peripheral CD4+ T cells, were detected by real-time quantitative RT-PCR and flow cytometry, and serum concentrations of IL-17 and IL-10 were detected by ELISA in 36 PV patients and 32 healthy controls. Additionally, CD4+ T cells from 12 PV patients were treated with γ -secretase inhibitor DAPT, and the above indexes were measured...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29673594/lincrna-ror-mir-145-promote-invasion-and-metastasis-in-triple-negative-breast-cancer-via-targeting-muc1
#16
Jianli Ma, Yue Yang, Desheng Huo, Zanyu Wang, Xiaoyu Zhai, Jing Chen, Huixin Sun, Weiwei An, Jing Jie, Pengxiang Yang
Triple-negative breast cancer (TNBC) was associated with high rates of cancer recurrence and metastasis and currently no available molecularly target. Accumulating evidences have established the importance of lincRNA-ROR as a marker of cancers. In order to better understand the mechanism of lincRNA-ROR in TNBC, we provided a novel molecular target into the regulatory invasion and metastasis in present research. We found that lincRNA-ROR was upregulated in TNBC cell lines and tissue samples. The aberrant expression of lincRNA-ROR was shown to increase invasion and metastasis in MDA-MB-231 and loss of function by siRNA reverse these process...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29671140/profiling-surgeon-performance-for-breast-cancer-lumpectomy-by-composite-measurement-of-reoperations-cosmetic-outcomes-and-patient-preferences
#17
Annie L Dunham, Luis D Ramirez, Choua A Vang, Jared H Linebarger, Jeffrey Landercasper
BACKGROUND: Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the model-reoperation rate (ROR) and cosmetic outcome (COSM). METHODS: A prospective database was reviewed for stage 0-3 patients undergoing initial lumpectomy by three surgeons from 2010 to 2015...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29663729/hepatitis-b-infection-reported-with-cancer-chemotherapy-analyzing-the-us-fda-adverse-event-reporting-system
#18
Akimasa Sanagawa, Yuji Hotta, Tomoya Kataoka, Yasuhiro Maeda, Masahiro Kondo, Yoshihiro Kawade, Yoshihiro Ogawa, Ryohei Nishikawa, Masahiro Tohkin, Kazunori Kimura
We conducted data mining using the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database on spontaneously reported adverse events to evaluate the association between anticancer drug therapy and hepatitis B infection. Reports of hepatitis B infection were retrieved from the FAERS database. The reporting odds ratio (ROR) was used to estimate the association between hepatitis B infection and various anticancer agents and drug combinations. We detected statistically significant risk signals of hepatitis B for 33 of 64 anticancer agents by ROR (26 cytotoxicity drugs and seven molecular-targeted drugs)...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29661234/characterization-of-serious-adverse-drug-reactions-as-cause-of-emergency-department-visit-in-children-a-5-years-active-pharmacovigilance-study
#19
Niccolò Lombardi, Giada Crescioli, Alessandra Bettiol, Ettore Marconi, Antonio Vitiello, Roberto Bonaiuti, Anna Maria Calvani, Stefano Masi, Ersilia Lucenteforte, Alessandro Mugelli, Lisa Giovannelli, Alfredo Vannacci
BACKGROUND: To describe frequency, preventability and seriousness of adverse drug reactions (ADRs) in children as cause of emergency department (ED) admission and to evaluate the association between specific factors and the reporting of ADRs. METHODS: A retrospective analysis based on reports of suspected ADRs collected between January 1st, 2012 and December 31st, 2016 in the ED of Meyer Children's Hospital (Italy). Demographics, clinical status, suspected drugs, ADR description, and its degree of seriousness were collected...
April 16, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29625335/cerebrospinal-fluid-il-10-as-an-early-stage-discriminative-marker-between-multiple-sclerosis-and-neuro-beh%C3%A3-et-disease
#20
Meriam Belghith, Khadija Bahrini, Mariem Kchaou, Olfa Maghrebi, Samir Belal, Mohamed Ridha Barbouche
Multiple Sclerosis (MS) and Neuro-Behçet's Disease (NBD) are two recurrent disorders affecting the central nervous system (CNS) by causing inflammation and irreversible damage. Inaugural clinical symptoms for both diseases might be very similar and definitive diagnosis could be delayed. The present study aimed to find out possible differences at early stages in the transcription factors/cytokines expression profiles in blood and cerebrospinal fluid (CSF) of MS and NBD patients which could be useful discriminative markers...
April 3, 2018: Cytokine
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