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https://www.readbyqxmd.com/read/29768534/impact-of-dexmedetomidine-on-hemodynamics-in-rabbits
#1
Jianjun Ren, Changfa Li, Shuxian Ma, Jiangli Wu, Yanjie Yang
PURPOSE: To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits. METHODS: A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29756692/the-presence-of-elastic-compression-stockings-reduces-the-fluid-responsiveness-of-patients-in-the-operating-room
#2
Elie Zogheib, Julien Maizel, Nabil Cherradi, Ammar Benammar, Béatrice Labont, Abdel Hchikat, Michael Bernasinski, Faouzi Trojette, Michel Slama, Hervé Dupont
BACKGROUND: To investigate whether elastic compression stockings (ECS) can affect fluid responsiveness parameters before and during passive leg raising (PLR) maneuvers. METHODS: In the operating room (OR), we performed a prospective study including patients referred for cardiac surgery. Blood pressure (BP), ΔPP, heart rate (HR), central venous pressure (CVP), stroke volume (SV) and aortic blood flow (ABF) (by esophageal doppler) were measured according to four conditions: supine position without ECS (baseline 1), lower limbs raised to an angle of 45° (PLR 1), returned to the supine position with ECS (baseline 2), then a second PLR maneuver with ECS was performed (PLR 2)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29747290/-the-relationship-between-arterial-blood-lactate-clearance-prognosis-and-myocardial-damage-in-patients-with-septic-shock-after-early-goal-directed-therapy
#3
X L Shang, D W Liu, X T Wang, H W He, H M Zhang, L X Su, P Pan
Objective: To evaluate the prognostic value of arterial blood lactate clearance based on central venous oxygen saturation and perfusion index in patients with septic shock related myocardial injury after early goal-directed therapy. Methods: One hundred and fifty-seven patients with septic shock after early resuscitation were enrolled from August 2013 to July 2016 in ICU at Peking Union Medical College Hospital. Parameters indicating early resuscitation included central venous pressure (CVP) 8-12 mmHg (1 mmHg=0...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29746600/impact-of-positive-end-expiratory-pressure-on-cerebral-hemodynamic-in-paediatric-patients-with-post-traumatic-brain-swelling-treated-by-surgical-decompression
#4
Silvia De Rosa, Gianluca Villa, Paola Franchi, Aldo Mancino, Federica Tosi, Marina Alessandra Martin, Simona Bazzano, Giorgio Conti, Silvia Maria Pulitanò
INTRODUCTION: The objective of our present study is to evaluate the impact of different PEEP levels on cerebral hemodynamic, gas exchanges and respiratory system mechanics in paediatric patients with post-traumatic brain swelling treated with decompressive craniectomy (DC). MATERIALS AND METHODS: A prospective physiologic study was carried out on 14 paediatric patients presenting with severe traumatic brain swelling treated with DC. Transcranial Doppler ultrasonography was performed on the middle cerebral artery bilaterally after DC...
2018: PloS One
https://www.readbyqxmd.com/read/29744618/association-between-central-venous-pressure-as-assessed-by-echocardiography-left-ventricular-function-and-acute-cardio-renal-syndrome-in-patients-with-st-segment-elevation-myocardial-infarction
#5
Shafik Khoury, Arie Steinvil, Amir Gal-Oz, Gilad Margolis, Aviram Hochstatd, Yan Topilsky, Gad Keren, Yacov Shacham
BACKGROUND: Recent reports have demonstrated the adverse effects of venous congestion on renal function in patients with heart failure. None of these trials, however, has evaluated the effect of acute myocardial ischemia on the occurrence of acute kidney injury (AKI). METHODS: We conducted a retrospective study of 1336 ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) between June 2012 and June 2016...
May 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29729082/a-case-series-of-perioperative-variables-in-relation-to-short-term-outcomes-in-pediatric-renal-transplant-recipients
#6
Celine Y Y Goh, Helen Hume-Smith, Nicos Kessaris, Stephen D Marks
Multiple perioperative variables have been shown in existing literature to influence long-term outcomes of pediatric RTx, such as allograft survival. Their impact on short-term outcomes is not as well-documented. This case series aims to investigate the effects of nine perioperative variables on two short-term outcomes in pRTR: 1-week post-operative eGFR and post-operative LOS. A total of 73 pRTR transplanted over 3 years from 2012 to 2014 at a single center were studied retrospectively and statistical analyses were performed...
May 5, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29722468/comparison-of-treatment-outcomes-between-convergent-procedure-and-catheter-ablation-for-paroxysmal-atrial-fibrillation-evaluated-with-implantable-loop-recorder-monitoring
#7
Matevž Jan, David Žižek, Živa Miriam Geršak, Borut Geršak
INTRODUCTION: While catheter ablation (CA) is an established treatment for symptomatic paroxysmal atrial fibrillation (AF), convergent epicardial and endocardial ablation procedure (CVP) has been primarily used to treat persistent AF. The aim of this single-center, prospective, randomized study was to compare treatment efficacy of CA and CVP in paroxysmal AF patients by monitoring AF, atrial tachycardia (AT) and atrial flutter (AFL) recurrence with Implantable Loop Recorder (ILR). METHODS AND RESULTS: Fifty patients (74% male) with history of paroxysmal AF were randomized between CA and CVP...
May 3, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29721645/midazolam-increases-preload-dependency-during-endotoxic-shock-in-rabbits-by-affecting-venous-vascular-tone
#8
Jianxiao Chen, Tao Yu, Federico Longhini, Xiwen Zhang, Songqiao Liu, Ling Liu, Yi Yang, Haibo Qiu
BACKGROUND: Septic patients often require sedation in intensive care unit, and midazolam is one of the most frequently used sedatives among them. But the interaction between midazolam and septic shock is not known. The aim of this study is to investigate the effects of midazolam on preload dependency in an endotoxic shock model by evaluating systemic vascular tone and cardiac function. METHODS: Eighteen rabbits were randomly divided into three groups: Control group, MID1 group and MID2 group...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29708882/does-it-take-a-village-fostering-gender-equity-among-early-adolescents-in-nepal
#9
Rebecka Lundgren, Susannah Gibbs, Brad Kerner
Background Gender inequity contributes to a range of poor health outcomes. Early adolescence presents a window of opportunity for gender transformative interventions to shift inequitable gender norms, attitudes and behaviors. Objective The objective of this study is to evaluate a set of individual, family and community interventions to increase gender equity among very young adolescents (VYAs) in rural Nepal. Methods Two communities received the individual-level Choices intervention as well the family and community Voices and Promises interventions (CVP)...
April 30, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29653247/somatosensory-changes-at-forearm-donor-sites-following-three-different-surgical-flap-techniques
#10
Fang Wang, Xu Ding, Jinglu Zhang, Xiaomeng Song, Yunong Wu, Peter Svensson, Kelun Wang
BACKGROUND: The aim of this study was to investigate the somatosensory changes at the forearm donor region after using different types of modified flap surgical techniques. METHODS: Thirty-one patients, who underwent oral and maxillofacial reconstructive surgery involving the use of a traditional radial forearm flap (TRFF) or two modified radial forearm flap techniques (MRFF-I; MRFF-II), participated in the study. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), pressure pain threshold (PPT), mechanical detection threshold (MDT), and mechanical pain threshold (MPT) were assessed at four sites of the forearms corresponding to the middle of the vascular pedicle (VP) area, the middle of the forearm flap area, and the corresponding contralateral sites (cVP and cFF) at about 5...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29614507/renoprotective-postoperative-monitoring-what-is-the-best-method-for-computing-renal-perfusion-pressure-an-observational-prospective-multicentre-study
#11
Csaba Kopitko, Laszlo Medve, Tibor Gondos
BACKGROUND: Low mean arterial pressure (MAP) is a well-known risk factor for postoperative acute kidney injury (AKI), but probably it is not the sole hemodynamic parameter that can influence the development of renal failure. There are data in cardiac patients supporting the role of renal venous congestion in the development of AKI. The aim of our study was to determine a combination of factors best predicting the development of AKI. METHODS: Data were collected prospectively for adult patients admitted after major abdominal surgery to 9 Hungarian intensive care units...
April 3, 2018: Nephron
https://www.readbyqxmd.com/read/29609914/an-online-cross-sectional-comparison-of-women-with-symptoms-of-persistent-genital-arousal-painful-persistent-genital-arousal-and-chronic-vulvar-pain
#12
Robyn A Jackowich, Leah Pink, Allan Gordon, Évéline Poirier, Caroline F Pukall
BACKGROUND: Persistent genital arousal disorder (PGAD) is an understudied condition characterized by unwanted physiologic genital arousal in the absence of subjective sexual arousal. Markos and Dinsmore (Int J STD AIDS 2013;24:852-858) theorized that PGAD shares a number of similarities with vulvodynia (unexplained chronic vulvar pain [CVP]), including symptom characteristics and comorbidities. AIM: To compare medical histories, symptom characteristics, pain characteristics, and daily functioning among women with persistent genital pain (PGA) (n = 42), painful PGA (n = 37), and CVP (n = 42) symptoms...
April 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29593416/influence-of-stroke-volume-variation-on-fluid-treatment-and-postoperative-complications-in-thoracic-surgery
#13
Cengiz Sahutoglu, Erbil Turksal, Seden Kocabas, Fatma Zekiye Askar
Background: Fluid management in critically ill patients usually relies on increasing preload to augment cardiac output. In the present study, we aimed to evaluate whether stroke volume variation (SVV) can guide fluid therapy and reduce complications. Patients and methods: In this retrospective study, a total of 88 patients who underwent lobectomy were divided into two groups: group 1 (SVV, n=43) and group 2 (conventional or central venous pressure [CVP], n=45). Heart rate, blood pressure, oxygen saturation, SVV (only group 1), CVP (all patients), urea, creatinine, and hemoglobin levels before and after surgery, use of fluid, blood and inotropic agents, and postoperative complications were recorded retrospectively...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29580146/segregating-the-distinct-effects-of-sedentary-behavior-and-physical-activity-on-older-adults-cardiovascular-profile-part-2-isotemporal-substitution-approach
#14
Declan J Ryan, Jorgen A Wullems, Georgina K Stebbings, Christopher I Morse, Claire E Stewart, Gladys L Onambele-Pearson
BACKGROUND: The aim of the study was to provide an isotemporal substitution model to predict how changes in physical behavior may affect the cardiovascular parameters (CVPs) of older adults. METHODS: Participants wore a thigh-mounted accelerometer for 7 days. Phenotype of the carotid, brachial, and popliteal artery was conducted using ultrasound. Isotemporal substitution was used to simulate the degree to which replacing 1 hour of physical behavior with another would affect CVP...
March 26, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29577856/blood-flow-regulates-zebrafish-caudal-vein-plexus-angiogenesis-by-erk5-klf2a-nos2b-signaling
#15
X Xie, T Zhou, Y Wang, H Chen, D Lei, L Huang, Y Wang, X Jin, T Sun, J Tan, T Yin, J Huang, H Gregersen, G Wang
Vascular network formation induced by angiogenesis plays an important role in many physiological and pathological processes. However, the role of blood flow and underlying mechanisms in vascular network formation, for example for the development of the caudal vein plexus (CVP), is poorly understood. In this study on tnnt2a-MO injection and chemical blood flow modulator treatment in zebrafish embryos, we demonstrated that decreased blood flow disrupted CVP formation. The hemodynamic force was quantitatively analyzed...
March 22, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29573604/value-of-the-combination-of-renal-resistance-index-and-central-venous-pressure-in-the-early-prediction-of-sepsis-induced-acute-kidney-injury
#16
Jieqiong Song, Wei Wu, Yizhou He, Shilong Lin, Duming Zhu, Ming Zhong
PURPOSE: Early prediction of acute kidney injury (AKI) in septic patients is difficult. This study aimed to assess the values of renal resistive index (RI), central venous pressure (CVP), and their combination in the early prediction of sepsis-induced AKI. METHODS: A prospective cohort study was performed in septic patients. The variables potentially associated with AKI were recorded at admission and compared between the AKI and non-AKI groups. The variables independently associated with sepsis-induced AKI were identified using multivariable logistic regression, and the area under the receiver operating characteristic curve (AUROC) analysis was calculated...
June 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29569112/phenylephrine-increases-cardiac-output-by-raising-cardiac-preload-in-patients-with-anesthesia-induced-hypotension
#17
A F Kalmar, S Allaert, P Pletinckx, J-W Maes, J Heerman, J J Vos, M M R F Struys, T W L Scheeren
Induction of general anesthesia frequently induces arterial hypotension, which is often treated with a vasopressor, such as phenylephrine. As a pure α-agonist, phenylephrine is conventionally considered to solely induce arterial vasoconstriction and thus increase cardiac afterload but not cardiac preload. In specific circumstances, however, phenylephrine may also contribute to an increase in venous return and thus cardiac output (CO). The aim of this study is to describe the initial time course of the effects of phenylephrine on various hemodynamic variables and to evaluate the ability of advanced hemodynamic monitoring to quantify these changes through different hemodynamic variables...
March 22, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29563210/venous-waveform-morphological-changes-associated-with-treatment-of-symptomatic-venous-sinus-stenosis
#18
James L West, Rebecca M Garner, Garret P Greeneway, Justin R Traunero, Carol A Aschenbrenner, Jasmeet Singh, Stacey Q Wolfe, Kyle M Fargen
INTRODUCTION: Venous outflow obstruction is recognized as a contributing factor in a subset of patients with idiopathic intracranial hypertension (IIH). Little is known about venous sinus waveform morphology or how it changes after stenting. METHODS: Fifteen patients with IIH underwent waveform recording during catheter venography and manometry. Ten patients (Group A) with venous sinus stenosis and pressure gradient ≥7 mm Hg underwent waveform recording during awake venography and during stenting under general anesthesia...
March 21, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29543518/the-heart%C3%A2-s-rhythm-n-blues-sex-differences-in-circadian-variation-patterns-of-vagal-activity-vary-by-depressive-symptoms-in-predominantly-healthy-employees
#19
Marc N Jarczok, Corina Aguilar-Raab, Julian Koenig, Michael Kaess, Jeremy C Borniger, Randy J Nelson, Martica Hall, Beate Ditzen, Julian F Thayer, Joachim E Fischer
INTRODUCTION: Successful regulation of emotional states is positively associated to mental health, while difficulties in regulating emotions are negatively associated to overall mental health and in particular associated with anxiety or depression symptoms. A key structure associated to socio-emotional regulatory processes is the central autonomic network. Activity in this structure is associated to vagal activity can be indexed noninvasively and simply by measures of peripheral cardiac autonomic modulations such as heart rate variability...
March 15, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29538440/impact-of-large-volume-paracentesis-on-respiratory-parameters-including-transpulmonary-pressure-and-on-transpulmonary-thermodilution-derived-hemodynamics-a-prospective-study
#20
Ulrich Mayr, Eugen Karsten, Tobias Lahmer, Sebastian Rasch, Philipp Thies, Benedikt Henschel, Gerrit Fischer, Roland M Schmid, Wolfgang Huber
INTRODUCTION: Appropriate mechanical ventilation and prevention of alveolar collaps is mainly dependent on transpulmonary pressure TPP. TPP is assessed by measurement of esophageal pressure EP, largely influenced by pleural and intraabdominal pressure IAP. Consecutively, TPP-guided ventilation might be particularly useful in patients with high IAP. This study investigates the impact of large volume paracentesis LVP on TPP, EP, IAP as well as on hemodynamic and respiratory function in patients with liver cirrhosis and tense ascites...
2018: PloS One
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