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Fluid responsiveness

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https://www.readbyqxmd.com/read/28339567/role-of-biomechanical-forces-in-hyperfiltration-mediated-glomerular-injury-in-congenital-anomalies-of-the-kidney-and-urinary-tract
#1
Tarak Srivastava, Ganesh Thiagarajan, Uri S Alon, Ram Sharma, Ashraf El-Meanawy, Ellen T McCarthy, Virginia J Savin, Mukut Sharma
Congenital anomalies of the kidney and urinary tract (CAKUT) including solitary kidney constitute the main cause of progressive chronic kidney disease (CKD) in children. Children born with CAKUT develop signs of CKD only during adolescence and do not respond to renin-angiotensin-aldosterone system blockers. Early cellular changes underlying CKD progression to end-stage renal disease by early adulthood are not well understood. The mechanism of maladaptive hyperfiltration that occurs from loss of functional nephrons, including solitary kidney, is not clear...
January 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28338557/ruthenium-106-brachytherapy-in-the-treatment-of-circumscribed-choroidal-hemangioma
#2
Masood Naseripour, Arash Maleki, Arezoo Astaraki, Ahad Sedaghat, Ramin Jaberi, Stacey Lee, Zohreh Azma, Sukhum Silpa-Archa
PURPOSE: To examine the efficacy and safety of Ruthenium-106 plaque radiotherapy in the treatment of circumscribed choroidal hemangioma. METHODS: Twenty-one eyes of 21 patients diagnosed with symptomatic circumscribed choroidal hemangioma who underwent Ruthenium-106 plaque radiotherapy were included in the study. Clinical response, ancillary tests finding improvement, and major side effects were evaluated. RESULTS: From the initial to the 1-year follow-up visits, vision improved in 12 eyes (57%), was stable in 7 eyes (33%), and became worse in 2 eyes (10%)...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28338391/modifications-in-human-oral-fibroblast-ultrastructure-collagen-production-and-lysosomal-compartment-in-response-to-e-cigarette-fluids
#3
Silvia Sancilio, Marialucia Gallorini, Amelia Cataldi, Laura Sancillo, Rosa Alba Rana, Viviana di Giacomo
Background Many smokers have recently turned to electronic cigarettes (e-cigarettes) because they have been marketed as a cheaper and safer smokeless alternative to traditional cigarettes, and a possible smoking cessation tool. Even though the safety of these electronic devices is still not fully known, there is evidence of their cytotoxicity on cells which belong to the oral cavity. In a previous paper the increase of reactive oxygen production and Bax expression, followed by the occurrence of apoptosis, were demonstrated in human gingival fibroblasts...
March 24, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28337914/electrically-actuated-valves-for-woven-fabric-lateral-flow-devices
#4
Tanya Narahari, Dhananjaya Dendukuri, Shashi K Murthy
The integration of flow control elements into low-cost biosensors, presents a significant engineering challenge. This article describes the development and integration of active, chemical valves into lateral flow devices, using a scalable, single-step, weaving-based manufacturing approach. The valve was constructed from an electrically conductive polymer, polypyrrole. The polymer switches between wetting and non-wetting states when it is reduced and oxidized via the application of an electrochemical potential...
March 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28337902/helicobacter-pylori-in-periodontal-pockets-and-saliva-a-possible-role-in-gastric-infection-relapses
#5
L Azzi, F Carinci, S Gabaglio, F Cura, F Croveri, L Tettamanti, A Tagliabue, S Segato
It has been a long time since the scientific community started to speculate upon the presence of Helicobacter pylori (HP) in periodontal pockets as an extra-gastric reservoir responsible for gastric relapses after eradication therapy. The aim of this study is to evaluate the presence of oral HP in a group of patients who underwent examination for gastric infection. Sixty patients were enrolled in the current study, subdivided into two groups: 30 patients with a positive result for HP gastric infection with C-Breath Test Urea examination, and 30 patients with a negative result for HP gastric infection...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337868/inflammation-in-lung-after-acute-myocardial-infarction-is-induced-by-dendritic-cell-mediated-immune-response
#6
L J Hu, W Y Ren, Q J Shen, H Y Ji, L Zhu
The present study was performed to describe the changes of lung tissues in mice with acute myocardial infarction (AMI) and also explain the cell mechanism involved in inflammation in lung. AMI was established by left coronary ligation in mice. Then mice were divided into three groups: control group, MW1 group (sampling after surgery for one week) and MW2 group (sampling after surgery for two weeks). Afterwards, measurement of lung weight and lung histology, cell sorting in bronchoalveolar lavage (BAL) fluid and detection of several adhesive molecules, inflammatory molecules as well as enzyme associated with inflammation were performed...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28336818/increased-exposure-to-sodium-during-pregnancy-and-lactation-changes-basal-and-induced-behavioral-and-neuroendocrine-responses-in-adult-male-offspring
#7
Marcia S Silva, Fabiana Lúcio-Oliveira, Andre Souza Mecawi, Lucas F Almeida, Silvia G Ruginsk, Michael P Greenwood, Mingkwan Greenwood, Laura Vivas, Lucila L K Elias, David Murphy, José Antunes-Rodrigues
Excessive sodium (Na(+)) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28336609/transition-from-turbulent-to-coherent-flows-in-confined-three-dimensional-active-fluids
#8
Kun-Ta Wu, Jean Bernard Hishamunda, Daniel T N Chen, Stephen J DeCamp, Ya-Wen Chang, Alberto Fernández-Nieves, Seth Fraden, Zvonimir Dogic
Transport of fluid through a pipe is essential for the operation of macroscale machines and microfluidic devices. Conventional fluids only flow in response to external pressure. We demonstrate that an active isotropic fluid, composed of microtubules and molecular motors, autonomously flows through meter-long three-dimensional channels. We establish control over the magnitude, velocity profile, and direction of the self-organized flows and correlate these to the structure of the extensile microtubule bundles...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28336525/extracellular-tdp-43-aggregates-target-mapk-mak-mrk-overlapping-kinase-mok-and-trigger-caspase-3-il-18-signaling-in-microglia
#9
María M Leal-Lasarte, Jaime M Franco, Adahir Labrador-Garrido, David Pozo, Cintia Roodveldt
Dysregulated microglial responses are central in neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar disease (FTLD). Pathologic TDP-43, which is typically found in intracellular inclusions, is a misfolding protein with emerging roles in ALS and FTLD. Recently, TDP-43 species have been found in extracellular fluids of patients; however, the overall implications of TDP-43-mediated signaling linked to neuroinflammation are poorly understood. Our work-the first, to our knowledge, to focus on innate immunity responses to TDP-43 aggregates-shows that such species are internalized by microglia and cause abnormal mobilization of endogenous TDP-43...
March 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28336260/the-analysis-of-human-conjunctival-epithelium-proteome-in-ocular-surface-diseases-using-impression-cytology-and-2d-dige
#10
Javier Soria, Arantxa Acera, Juan A Durán, Ana Boto-de-Los-Bueis, Almudena Del-Hierro-Zarzuelo, Nerea González, Rebeca Reigada, Tatiana Suárez
Conjunctival impression cytology samples from patients with meibomian gland dysfunction (MGD), dry eye (DE), and healthy subjects (CT) were collected for determination of the degree of squamous metaplasia (SM) by PAS-hematoxylin staining and for comparative proteomic analyses by 2D-DIGE. The protein spots with discriminant expression were identified by MALDI-TOF/TOF mass spectrometry. Three independent statistical studies were conducted: i). Analysis of differential protein expression between study groups: We observed increased expression of proteins S100A4, S100A8, retinal dehydrogenase-1, peroxiredoxin-1, annexin-A1, annexin-A2, α-enolase, and glutathione S-transferase-P in DE, whereas the highest expression of peroxiredoxin-6, actin cytoplasmic-1, peroxiredoxin-2, and heat shock protein HSP-90-α was observed in MGD; ii)...
March 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28336072/microneedle-enzyme-sensor-arrays-for-continuous-in-vivo-monitoring
#11
Anthony E G Cass, Sanjiv Sharma
Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28335648/inflammation-and-pharmacokinetics-potential-implications-for-hiv-infection
#12
Sharon M Seifert, Jose R Castillo-Mancilla, Kristine M Erlandson, Peter L Anderson
The physiological changes accompanying inflammation may alter the pharmacokinetics (PK) of certain medications. Individuals infected with HIV have chronically elevated inflammatory markers despite viral suppression following effective antiretroviral therapy (ART), as well as age-related inflammation. Understanding the potential clinical implications of inflammation on the PK of medications is important for understanding dose-response relationships and necessitates future research. Areas covered: An extensive literature search was carried out using PubMed and associated bibliographies to summarize the current state of knowledge regarding altered PK in response to inflammation and its application to the field of HIV...
March 24, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28335396/optimization-of-conditions-for-cyanidin-3-oglucoside-c3g-nanoliposome-production-by-response-surface-methodology-and-cellular-uptake-studies-in-caco-2-cells
#13
Tisong Liang, Rongfa Guan, Haitao Shen, Qile Xia, Mingqi Liu
We aimed to optimize the formulation of C3G nanoliposomes using response surface methodology. Additionally, we evaluated the stability, particle change, and encapsulation efficiency (EE) of C3G nanoliposomes under different temperatures and storage durations, as well as in simulated gastrointestinal juice (SGF) and simulated intestinal fluid. The morphology of C3G nanoliposomes was observed by transmission electron microscope. The ability of C3G nanoliposomes to affect cancer cell morphology and inhibit cancer cell proliferation was studied with Caco-2 cells...
March 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335297/rotation-of-magnetization-derived-from-brownian-relaxation-in-magnetic-fluids-of-different-viscosity-evaluated-by-dynamic-hysteresis-measurements-over-a-wide-frequency-range
#14
Satoshi Ota, Ryoichi Kitaguchi, Ryoji Takeda, Tsutomu Yamada, Yasushi Takemura
The dependence of magnetic relaxation on particle parameters, such as the size and anisotropy, has been conventionally discussed. In addition, the influences of external conditions, such as the intensity and frequency of the applied field, the surrounding viscosity, and the temperature on the magnetic relaxation have been researched. According to one of the basic theories regarding magnetic relaxation, the faster type of relaxation dominates the process. However, in this study, we reveal that Brownian and Néel relaxations coexist and that Brownian relaxation can occur after Néel relaxation despite having a longer relaxation time...
September 10, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335253/soft-interaction-in-liposome-nanocarriers-for-therapeutic-drug-delivery
#15
REVIEW
Domenico Lombardo, Pietro Calandra, Davide Barreca, Salvatore Magazù, Mikhail A Kiselev
The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action...
June 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334407/organismal-and-spatial-partitioning-of-energy-and-macronutrient-transformations-within-a-hypersaline-mat
#16
Jennifer M Mobberley, Stephen R Lindemann, Hans C Bernstein, James J Moran, Ryan S Renslow, Jerome Babauta, Dehong Hu, Haluk Beyenal, William C Nelson
Phototrophic mat communities are model ecosystems for studying energy cycling and elemental transformations because complete biogeochemical cycles occur over millimeter-to-centimeter scales. Characterization of energy and nutrient capture within hypersaline phototrophic mats has focused on specific processes and organisms, however little is known about community-wide distribution of and linkages between these processes. To investigate energy and macronutrient capture and flow through a structured community, the spatial and organismal distribution of metabolic functions within a compact hypersaline mat community from Hot Lake have been broadly elucidated through species-resolved metagenomics and geochemical, microbial diversity, and metabolic gradient measurements...
March 15, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28334198/molecular-mechanisms-involved-in-the-interaction-of-neisseria-meningitidis-with-cells-of-the-human-blood-cerebrospinal-fluid-barrier
#17
Alexandra Schubert-Unkmeir
Neisseria meningitidis is one of the most common aetiological agents of bacterial meningitis, affecting predominantly children and young adults. The interaction of N. meningitidis with human endothelial cells lining blood vessels of the blood-cerebrospinal-fluid barrier (B-CSFB) is critical for meningitis development. In recent decades, there has been a significant increase in understanding of the molecular mechanisms involved in the interaction of N. meningitidis with brain vascular cells. In this review, we will describe how N...
March 3, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28333858/immune-reconstitution-inflammatory-syndrome-causing-progressive-optic-nerve-edema-in-cryptococcal-meningitis
#18
Astrid C Werner, Laurel N Vuong, Thomas R Hedges, Caroline R Baumal
PURPOSE: To report an human immunodeficiency virus-positive patient undergoing therapy for cryptococcal meningitis who developed progressive optic disc edema that was steroid responsive. METHODS: Observational case report. RESULTS: One month after commencing antifungal treatment for cryptococcal meningitis, the patient developed bilateral, progressive, recurrent optic disc edema with subretinal fluid that coincided with initiation of highly active antiretroviral therapy and recovery of CD4 cell counts...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333855/serous-retinopathy-associated-with-cisplatin-treatment
#19
Spencer Langevin, Jonathan S Chang, Stanley Chang
BACKGROUND/PURPOSE: To describe a case of serous retinopathy and associated photoreceptor atrophy after intravenous cisplatin therapy. METHODS: Evaluation was performed using electroretinogram, optical coherence tomography, fundus autofluorescence, and funduscopic examinations to assess the extent of retinal disease, toxicity, and eventual atrophy. RESULTS: A 56 year-old man with metastatic small cell carcinoma with vision changes after initiation of cisplatin therapy...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333572/new-insights-on-complement-inhibitor-cd59-in-mouse-laser-induced-choroidal-neovascularization-mislocalization-after-injury-and-targeted-delivery-for-protein-replacement
#20
Gloriane Schnabolk, Mee Keong Beon, Stephen Tomlinson, Bärbel Rohrer
PURPOSE: The membrane attack complex (MAC) in choriocapillaris (CC) and retinal pigment epithelium (RPE) increase with age and disease (age-related macular degeneration). MAC assembly can be inhibited by CD59, a membrane-bound regulator. Here we further investigated the role of CD59 in murine choroidal neovascularization (CNV), a model involving both CC and RPE, and tested whether CR2-CD59, a soluble targeted form of CD59, provides protection. METHODS: Laser-induced CNV was generated in wild type and CD59a-deficient mice (CD59(-/-))...
March 23, 2017: Journal of Ocular Pharmacology and Therapeutics
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