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Wei DU, Changhe Pang, Yake Xue, Qingjun Zhang, Xinting Wei
It has previously been reported that dihydroartemisinin (DHA) is an effective novel anticancer compound in a number of types of tumor cells. Previous studies have demonstrated the anticancer activity of DHA in gioma cells. However, its underlining mechanism remains unclear. In the present study, the anticancer activity of DHA was examined in the glioma cell lines BT325 and C6. Western blot analysis was also employed to determine the signaling pathway changes. It was demonstrated that DHA effectively inhibited cell growth and induced apoptosis in glioma cells...
November 2015: Oncology Letters
Micha Barchana, Menahem Margaliot, Irena Liphshitz
INTRODUCTION: Mobile phones are in extensive use worldwide and concerns regarding their role in tumor formation were raised. Over the years multiple studies were published in order to investigate this issue using several approaches. The current study looks at secular trends of brain gliomas (low and high grade) incidence and changes in tumor's laterality over 30 years in a population extensively using this technology with a possible correlation to the spread of use of mobile phones. MATERIALS AND METHODS: All brain gliomas that were diagnosed from 1980-2009 were included and subdivided into two groups--low and high grade...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Zarina Begum, Susobhan Sarkar, Joydeep Mukherjee, Anirban Ghosh, Samares Chaudhuri, Swapna Chaudhuri
BACKGROUND: Microglial cells are considered to be the chief immunomodulatory cells of the brain. These cells play a crucial role against various neurodegenerative diseases. When modulated microglia have been shown to exert a potential anti-tumor immune response against brain neoplasms. Although several specific BRMs like IL-2, IFNgamma have been shown to modulate the microglia to get an effective anti-tumor immune response, associated toxicities and detrimental side effects have posed severe limitation in there use particularly for therapeutic purposes...
July 2003: Cancer Biology & Therapy
Celia Chen, Salim Okera, Peter E Davies, Dinesh Selva, John L Crompton
PURPOSE: To assess the clinical presentation and long-term visual outcome in a series of patients with craniopharyn-gioma. METHODS: Retrospective case review. RESULTS: Thirty-six patients were reviewed, comprising 19 female patients and 17 male patients. The age range was 2-77 years with a bimodal distribution of 17 children (mean age 10 years) and 19 adults (mean age 47 years). Blurred vision was the most common visual complaint (23 cases, 64%) and headache the most frequent systemic complaint (19 cases, 53%)...
June 2003: Clinical & Experimental Ophthalmology
R Alemany, C Gómez-Manzano, J Fueyo
The transfer of genetic material as a therapy (gene therapy) is one of the experimental treatments being considered in patients with brain tumors resistant to any conventional treatment. Several clinical trials have proved that the intratumoral administration of genes is fairly safe for patients, however the anti-tumor effect of these strategies remains suboptimal. One of the main problems in cancer gene therapy is the failure of current vectors to achieve enough tumor transduction in a suficient number of cells...
March 2001: Neurología: Publicación Oficial de la Sociedad Española de Neurología
S J Nygaard, P H Pedersen, T Mikkelsen, A J Terzis, O B Tysnes, R Bjerkvig
Confrontation cultures between glioma spheroids and brain cell aggregates are well established in glioma research, and the model reflects several similarities to the in vivo brain tumour invasive process. The lipid-binding fluorescent carbocyanine dyes DiO (3,3'-dioctadecyloxacarbocyanine perchlorate) and DiI (1,1'-dioctadecyl-3,3,3,'3,'-tetramethylinocarbocyanine perchlorate) are widely used in cell biology as tracers for studying cell movement. Mature brain cell aggregates grown from fetal rat brain cells, and spheroids initiated from two glioma cell lines (GaMg and D-54Mg) were stained with DiO and DiI, respectively...
1995: Invasion & Metastasis
J Hildebrand, R Badjou, E Collard-Ronge, A Delforge, M Malarme, T Spiro, B Sztern, A Vandensteene, P A Stryckmans
Seven patients with recurrent brain gliomas were treated by a single dose of CCNU 390 mg per m2. In five cases, chemotherapy was followed by autologous bone marrow transfusion containing 1.5 to 3 X 10(8) nucleated cells, 2.8 to 18 X 10(4) clusters plus colonies and 0.4 to 5 X 10(4) colonies forming cells per kg of body weight. Two patients were not grafted. None of these patients showed a clear cut response to the treatment as judged by clinical improvement and changes of the brain CT-scan. In 3 patients blood toxicity occurred early and was severe...
May 1980: Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
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