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https://www.readbyqxmd.com/read/29673703/snake-venoms-from-angola-intra-specific-variations-and-immunogenicity
#1
Paula Regina Simões de Oliveira, Felipe Silva de França, Isadora Maria Villas Boas, Marisa Maria Teixeira da Rocha, Sávio Stefanini Sant'Anna, Maria de Lourdes Bastos, Denise V Tambourgi
Snakebite is a public health problem in many countries of world. These accidents are considered a Neglected Tropical Disease and are responsible for a high morbidity and mortality index in the South and Southeast Asia and Sub-Saharan Africa. Angolan snake venoms are poorly investigated and no specific antivenom against them is available in the country. Thus, the aim of this study was to evaluate biochemical and immunogenic properties of male and female venoms from Naja nigricollis, Bitis arietans and Bitis gabonica snakes...
April 16, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29666096/devil-is-in-the-detail
#2
John Roshan Jacob, Amal Paul, Anoop George Alex
A 15-year-old girl of Asian origin, hailing from a rural agrarian background, presented with history of multiple episodes of dizziness for 3 years. The episodes were precipitated mostly by emotional and/or physical stress and relieved on lying down, with a few episodes culminating in transient loss of consciousness. As preliminary cardiac and neurological evaluation were normal, she was being treated by the primary physician as a case of probable psychogenic syncope, supported by the consistent association of the episodes with emotional stress...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29664034/incidence-prognosis-of-acute-kidney-injury-in-individuals-of-snakebite-in-a-tertiary-care-hospital-in-india
#3
Ramulu Pulimaddi, Amruth Rao Parveda, Balkishan Brahmanpally, Paul Marx Kalakanda, K Ramakrishna, Venkata Ramana Devi Chinnapaka
Background & objectives: The snakebites are considered to be an occupational hazard in agriculture workers and the snake handlers, resulting in a considerable morbidity, mortality and economical implications. This study was conducted to determine the incidence, clinical presentation, renal injury and clinical outcome in snakebite victims who developed acute kidney injury (AKI). Methods: This hospital-based prospective, observational study was done on 100 cases who were admitted for the management of snakebite and found to develop AKI in a tertiary care hospital at Hyderabad, India...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29662699/quality-of-who-guidelines-on-snakebite-the-neglect-continues
#4
Soumyadeep Bhaumik, Soushieta Jagadesh, Zohra Lassi
No abstract text is available yet for this article.
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29661659/the-association-between-heat-waves-and-other-meteorological-parameters-and-snakebites-israel-national-study
#5
Sagi Shashar, Maayan Yitshak-Sade, Roman Sonkin, Victor Novack, Eli Jaffe
BACKGROUND: Published annual estimates report a global burden of 2.5 million snakebite cases and >100,000 deaths. In Israel, envenomations are the third most frequent cause of poisonings that are of moderate to major clinical severity. Most studies focus on the clinical descriptions of snakebites in tropical climates, and we sought to investigate the association between snakebite frequency and meteorological parameters. OBJECTIVE: We sought to investigate the seasonality of snakebites and evaluate the association between increasingly common heat waves and other meteorological parameters and snakebite frequency in a semiarid nontropical climate...
April 13, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29659601/in-vitro-assessment-of-cytotoxic-activities-of-lachesis-muta-muta-snake-venom
#6
Stephanie Stransky, Fernanda Costal-Oliveira, Letícia Lopes-de-Souza, Clara Guerra-Duarte, Carlos Chávez-Olórtegui, Vania Maria Martin Braga
Envenomation by the bushmaster snake Lachesis muta muta is considered severe, characterized by local effects including necrosis, the main cause of permanent disability. However, cellular mechanisms related to cell death and tissue destruction, triggered by snake venoms, are poorly explored. The purpose of this study was to investigate the cytotoxic effect caused by L. m. muta venom in normal human keratinocytes and to identify the cellular processes involved in in cellulo envenomation. In order to investigate venom effect on different cell types, Alamar Blue assay was performed to quantify levels of cellular metabolism as a readout of cell viability...
April 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29657394/ethnoveterinary-treatments-for-common-cattle-diseases-in-four-districts-of-the-southern-province-zambia
#7
Michelo Syakalima, Martin Simuunza, Victor Chisha Zulu
Aim: Ethno veterinary knowledge has rarely been recorded, and no or limited effort has been made to exploit this knowledge despite its widespread use in Zambia. This study documented the types of plants used to treat important animal diseases in rural Zambia as a way of initiating their sustained documentation and scientific validation. Materials and Methods: The study was done in selected districts of the Southern Zambia, Africa. The research was a participatory epidemiological study conducted in two phases...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29651298/true-or-false-coral-snake-is-it-worth-the-risk-a-micrurus-corallinus-case-report
#8
Marcelo Abrahão Strauch, Guilherme Jones Souza, Jordana Nahar Pereira, Tyelli Dos Santos Ramos, Marcelo Oliveira Cesar, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto, Paulo A Melo
Background: Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus , which together represent almost 80% of accidents. In addition to their less aggressive behavior, habits and morphology of coral snakes are determinant factors for such low incidence of accidents. Although Micrurus bites are rare, victims must be rescued and hospitalized in a short period of time, because this type of envenoming may evolve to a progressive muscle weakness and acute respiratory failure...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29629287/infrequent-use-of-medicinal-plants-from-india-in-snakebite-treatment
#9
REVIEW
Manali Sughosh Upasani, Sughosh Vishweshwar Upasani, Vishal Gokul Beldar, Chetana Gokul Beldar, Pranjal P Gujarathi
Snakes have fascinated humankind for millennia. Snakebites are a serious medical, social, and economic problem that are experienced worldwide; however, they are most serious in tropical and subtropical countries. The reasons for this are 1) the presence of more species of the most dangerous snakes, 2) the inaccessibility of immediate medical treatment, and 3) poor health care. The goal of this study was to collect information concerning rare, less utilized, and less studied medicinal plants. More than 100 plants were found to have potential to be utilized as anti-snake venom across India...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29626137/snakebites-in-africa-and-europe-a-military-perspective-and-update-for-contemporary-operations
#10
REVIEW
Daniel Wilkins, D S Burns, D Wilson, D A Warrell, L E M Lamb
Snakebite envenoming is rare among military patients, with few cases reported in recent years. Increasingly, however, military operations are taking place in remote parts of Africa, which are inhabited by numerous species of venomous snake, and in Europe, where dangerous species exist but are less common. Bites from a venomous snake may prove fatal, and therefore military medics must be adequately prepared to manage them. This paper reviews the most medically significant species of venomous snake present in Africa and Europe, before suggesting an evidence-based approach to snakebite prevention and management, including possible changes to the UK's Clinical Guidelines for Operations...
April 5, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29621529/severe-snakebite-envenomation-in-french-guiana-when-antivenom-is-not-available
#11
Hatem Kallel, Claire Mayence, Stéphanie Houcke, Cyrille Mathien, Hossein Mehdaoui, José María Gutiérrez, Bruno Megarbane, Didier Hommel, Dabor Resiere
In French Guiana, Bothrops atrox, Bothrops brazili, Bothrops bilineatus, Lachesis muta and Micrurus sp are responsible for most cases of snakebite envenomation. The clinical features in patients suffering from envenomations by viperid snakes involve local tissue damage and systemic manifestations, such as hemorrhage, coagulopathies and hemodynamic instability. We report a severe case of envenomation in a patient bitten by a large unidentified pit viper in French Guiana. Due to lack of antivenom, the patient only received symptomatic management...
April 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29621528/what-can-be-learned-in-the-snake-antivenom-field-from-the-developments-in-human-plasma-derived-products
#12
Thierry Burnouf
Human plasma-derived medicinal products and snake antivenom immunoglobulins are unique and complex therapeutic protein products. Human plasma products are obtained by fractionating large pools of plasma collected from blood plasma donors. They comprise a wide range of protein products, including polyvalent and hyperimmune immunoglobulins, coagulation factors, albumin, and various protease inhibitors that are transfused to patients affected by congenital or acquired protein deficiencies, immunological disorders, or metabolic diseases...
April 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29617989/knowledge-of-venomous-snakes-snakebite-first-aid-treatment-and-prevention-among-clinicians-in-northern-nigeria-a-cross-sectional-multicentre-study
#13
Godpower C Michael, Bukar A Grema, Ibrahim Aliyu, Mohammed A Alhaji, Teslim O Lawal, Haliru Ibrahim, Aminu G Fikin, Fatima S Gyaran, Kennedy N Kane, Thomas D Thacher, Abba K Badamasi, Emmanuel Ogwuche
Background: Snakebite envenoming causes considerable morbidity and mortality in northern Nigeria. The clinician's knowledge of snakebite impacts outcome. We assessed clinicians' knowledge of snakebite envenoming to highlight knowledge and practice gaps for possible intervention to improve snakebite outcomes. Methods: This was a cross-sectional multicentre study of 374 doctors selected from the accident and emergency, internal medicine, family medicine/general outpatient, paediatrics and surgery departments of nine tertiary hospitals in northern Nigeria using a multistage sampling technique...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29616630/the-antivenom-efficacy-against-a-viper-bite-without-medical-treatment-for-3-days-a-case-report
#14
H Alaoui, Y Aissaoui, M Zoubir, M Boughalem
Snakebites can be deadly, depending on the course of extremely serious hemorrhagic complications in the absence of antivenom, which remains the only specific and effective treatment, if it is introduced in time. We report the case of a young patient of 18 years, bitten by a snake and receiving only tradition care until admission to intensive care 3 days later, with advanced bleeding and inflammation; four vials of FAV-Africa antivenom were administered and resulted in dramatic improvement in his condition. This result confirms the empirical concept that delay in management should under no circumstances exclude the administration of antivenom...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29615942/association-between-fear-and-beauty-evaluation-of-snakes-cross-cultural-findings
#15
Eva Landová, Natavan Bakhshaliyeva, Markéta Janovcová, Šárka Peléšková, Mesma Suleymanova, Jakub Polák, Akif Guliev, Daniel Frynta
According to the fear module theory, humans are evolutionarily predisposed to perceive snakes as prioritized stimuli and exhibit a fast emotional and behavioral response toward them. In Europe, highly dangerous snake species are distributed almost exclusively in the Mediterranean and Caspian areas. While the risk of a snakebite is relatively low in Central Europe, Azerbaijan, on the other hand, has a high occurrence of the deadly venomous Levant viper ( Macrovipera lebetina ). We hypothesize that co-habitation with this dangerous snake has shaped the way in which humans evaluate snake species resembling it...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29611503/accuracy-of-the-lee-white-clotting-time-performed-in-the-hospital-routine-to-detect-coagulopathy-in-bothrops-atrox-envenomation
#16
Jose Diego de Brito Sousa, Jacqueline Almeida Gonçalves Sachett, Sâmella Santos Oliveira, Iran Mendonça-da-Silva, Hedylamar Oliveira Marques, Marcus Vinicius Guimarães de Lacerda, Hui Wen Fan, Wuelton Marcelo Monteiro
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee-White clotting time (LWCT) is a simple and inexpensive test and available even in remote health facilities. However, the diagnostic value of such test needs to be evaluated to accurately diagnose coagulopathy in the clinical practice. This study aimed to assess the reliability of the LWCT performed in hospital routine to diagnose venom-induced coagulopathy...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29572088/predictive-factors-for-death-after-snake-envenomation-in-myanmar
#17
Kyi-Phyu Aye, Vipa Thanachartwet, Chit Soe, Varunee Desakorn, Supat Chamnanchanunt, Duangjai Sahassananda, Thanom Supaporn, Visith Sitprija
INTRODUCTION: Factors predictive for death from snake envenomation vary between studies, possibly due to variation in host genetic factors and venom composition. This study aimed to evaluate predictive factors for death from snake envenomation in Myanmar. METHODS: A prospective study was performed among adult patients with snakebite admitted to tertiary hospitals in Yangon, Myanmar, from May 2015 to August 2016. Data including clinical variables and laboratory parameters, management, and outcomes were evaluated...
March 20, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29547237/snakebite-poisoning-in-spain
#18
Cristina Martín-Sierra, Santiago Nogué-Xarau, Miguel Ángel Pinillos Echeverría, José Miguel Rey Pecharromán
Emergencies due to snakebites, although unusual in Spain, are potentially serious. Of the 13 species native to the Iberian peninsula, only 5 are poisonous: 2 belong to the Colubridae family and 3 to the Viperidae family. Bites from these venemous snakes can be life-threatening, but the venomous species can be easily identified by attending to certain physical traits. Signs denoting poisoning from vipers, and the appropriate treatment to follow, have changed in recent years.
2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29546833/natural-snake-venom-inhibitors-and-their-pharmaceutical-uses-challenges-and-possibilities
#19
Soledad Lorena Saavedra, Lucia Avila, Silvana Laura Giudicessi, Fernando Albericio, Silvia Andrea Camperi, Osvaldo Cascone, Maria Camila Martinez-Ceron
Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms...
February 23, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29530470/snakebites-treated-in-north-carolina-emergency-departments-october-2013-september-2015
#20
Katherine J Harmon, Marilyn Goss Haskell, Courtney H Mann, Anna E Waller
INTRODUCTION: North Carolina (NC) is home to more than 30 species of indigenous venomous and nonvenomous snakes. Snakebites can cause debilitating and potentially fatal injuries. However, there is a lack of current information available describing the incidence of snakebites in NC. Therefore, we performed this study of snakebites treated in NC emergency departments (EDs) using the statewide syndromic surveillance system, the North Carolina Disease Event Tracking and Epidemiologic Collection Tool (NC DETECT)...
March 9, 2018: Wilderness & Environmental Medicine
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