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https://www.readbyqxmd.com/read/29203373/betulinic-oleanolic-and-ursolic-acids-inhibit-the-enzymatic-and-biological-effects-induced-by-a-p-i-snake-venom-metalloproteinase
#1
Lina María Preciado, Paola Rey-Suárez, Isabel Cristina Henao, Jaime Andrés Pereañez
Betulinic acid (BA), Oleanolic acid (OA) and Ursolic acid (UA), are pentacyclic triterpenoids with widespread occurrence throughout the plant kingdom, these compounds are widely recognized by their pharmacological and biological properties, such as, anti-tumoral, anti-inflammatory, anti-microbial and hepatoprotective activity. In this work we determined the inhibitory ability of these compounds on the enzymatic, hemorrhagic, myotoxic and edema-inducing activities of Batx-I, a P-I metalloproteinase isolated from Bothrops atrox venom...
December 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29201102/enzymatic-analysis-of-iranian-echis-carinatus-venom-using-zymography
#2
Mostafa Kamyab, Euikyung Kim, Seyed Mehdi Hoseiny, Ramin Seyedian
Snakebite is a common problem especially in tropical areas all over the world including Iran. Echis carinatus as one of the most dangerous Iranian snakes is spreading in this country excluding central and northwest provinces. In this study gelatinase and fibrinogenolytic properties as two disintegrating matrix metalloproteinase enzymes were evaluated by a strong clear halo between 56-72 kDa in addition to another band located 76-102 kDa for gelatinase and one major band around 38 kDa for fibrinogenolytic enzyme respectively...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29183746/assessment-of-the-anti-snakebite-properties-of-extracts-of-aniba-fragrans-ducke-lauraceae-used-in-folk-medicine-as-complementary-treatment-in-cases-of-envenomation-by-bothrops-atrox
#3
Valéria Mourão de Moura, Noranathan da Costa Guimarães, Luana Travassos Batista, Luciana A Freitas-de-Sousa, Joanderson de Sousa Martins, Maria Carolina Scheffer de Souza, Patrícia D Oliveira de Almeida, Wuelton Marcelo Monteiro, Ricardo Bezerra de Oliveira, Maria Cristina Dos-Santos, Rosa Helena Veras Mourão
ETHNOPHARMACOLOGICAL RELEVANCE: Extracts of leaves and bark of Aniba fragrans are used as tea (decoction) to treat snakebites in communities in the Brazilian Amazon. The aqueous extract of the leaves of A. fragrans has been proven to be effective against Bothrops venom, but only when pre-incubated with the venom. This study sought to assess the potential of different types of extract of this species to inhibit the biological activities of Bothrops atrox venom (BaV) when used the same way as in folk medicine...
November 25, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29181643/vibrational-spectroscopy-of-muscular-tissue-intoxicated-by-snake-venom-and-exposed-to-photobiomodulation-therapy
#4
Willians Fernando Vieira, Bruno Kenzo-Kagawa, Maria Helena Mesquita Britto, Helder José Ceragioli, Kumiko Koibuchi Sakane, Vitor Baranauskas, Maria Alice da Cruz-Höfling
The pathogenesis of myonecrosis caused by myotoxins from bothropic venom is associated with local extracellular matrix (ECM) disintegration, hemorrhage, and inflammation. Search for alternative methods associated with serum therapy is mandatory to neutralize the fast development of local damage following snakebites. The experimental use of photobiomodulation therapy (PBMT) in murine models has shown promising results relative to structural and functional recovery from bothropic snakebite-induced myonecrosis...
November 28, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29179990/snakebite-by-micrurus-averyi-schmidt-1939-in-the-brazilian-amazon-basin-case-report-coral-snakebite-by-micrurus-averyi
#5
REVIEW
Iran Mendonça da Silva, Jorge Contreras Bernal, Pedro Ferreira Gonçalves Bisneto, Antônio Magela Tavares, Valéria Mourão de Moura, Claudio S Monteiro-Junior, Rima Raad, Paulo Sergio Bernarde, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro
Micrurus snakes, commonly known as coral snakes, are responsible for 0.4% of the snakebites envenomings in Brazil. In this report, we describe a case of envenoming by Micrurus averyi, the black-headed coral snake, recorded in the western Brazilian Amazon. To the best of our knowledge, this is the first published case perpetrated by this species. The major complaint of the patient was an intense local pain and paresthesia. Examination of the bite site revealed edema extending from the left foot up the left leg that was accompanied by erythema involving the foot and distal third of the leg...
November 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29176824/safety-and-efficacy-of-a-freeze-dried-trivalent-antivenom-for-snakebites-in-the-brazilian-amazon-an-open-randomized-controlled-phase-iib-clinical-trial
#6
Iran Mendonça-da-Silva, Antônio Magela Tavares, Jacqueline Sachett, José Felipe Sardinha, Lilian Zaparolli, Maria Fátima Gomes Santos, Marcus Lacerda, Wuelton Marcelo Monteiro
BACKGROUND: In tropical areas, a major concern regarding snakebites treatment effectiveness relates to the failure in liquid antivenom (AV) distribution due to the lack of an adequate cold chain in remote areas. To minimize this problem, freeze-drying has been suggested to improve AV stability. METHODS AND FINDINGS: This study compares the safety and efficacy of a freeze-dried trivalent antivenom (FDTAV) and the standard liquid AV provided by the Brazilian Ministry of Health (SLAV) to treat Bothrops, Lachesis and Crotalus snakebites...
November 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29171346/computational-and-in-vitro-insights-on-snake-venom-phospholipase-a2-inhibitor-of-phytocompound-ikshusterol3-o-glucoside-of-clematis-gouriana-roxb-ex-dc
#7
Sathishkumar Chinnasamy, Subbiah Nagarajan, Thirunavukkarasu Sivaraman, Karthikeyan Muthusamy
Ikshusterol3-O-glucoside was isolated from Clematis gouriana Roxb. ex DC root. A structure of the isolated compound was determined on the basis of various spectroscopic interpretations (UV, NMR, FTIR, and GC-MS-EI). This structure was submitted in the PubChem compound database (SID 249494133). SID 249494133 was carried out by density functional theory calculation to observe the chemical stability and electrostatic potential of this compound. The absorption, distribution, metabolism, excretion (ADME) property of this compound was predicted to evaluate the drug likeness and toxicity...
November 24, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29158707/a-novel-monocyclic-triterpenoid-and-a-norsesquaterpenol-from-the-aerial-parts-of-suaeda-monoica-forssk-ex-j-f-gmel-with-cell-proliferative-potential
#8
Mansour S Al-Said, Nasir A Siddiqui, Mohamed Ahmed Mukhair, Mohammad K Parvez, Perwez Alam, Mohd Ali, Anzarul Haque
Suaeda monoica Forssk. ex J.F. Gmel (Chenopodiaceae), a mangrove herb, is distributed in tropical Africa, Arabian Peninsula, India, Pakistan, Palestine and Jordan. The plant parts are used to treat sore throat, hepatitis, wounds, rheumatism, paralysis, asthma, snakebites, skin disease and ulcer. Two new phytoconstituents characterized as 13,17-octahydropentalene-4,4,10,23-tetramethyl-17,21-diisopropyl-tetradecahydrocyclo-[a]-phenanthrene-(14), 20(23), 21(30)-trien-5α-ol (SMC-3) and [1,4,4-trimethyl-cyclopent-1(5)-enyl]-9,10,17,21-tetramethyl-9α-ol-16α (17α)-epoxy heptadecan-6,10-dione (SMC-4) belong to the class norsesquaterpenol and monocyclic triterpenoid, respectively, along with two known compounds 3-epi-lupeol (SMC-1) and 4-cyclopentylpyrocatechol (SMC-2) have been isolated from the ethanol extract of aerial parts of S...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29155815/allopurinol-attenuates-acute-kidney-injury-following-bothrops-jararaca-envenomation
#9
Pedro Henrique França Gois, Monique Silva Martines, Daniela Ferreira, Rildo Volpini, Daniele Canale, Ceila Malaque, Renato Crajoinas, Adriana Castello Costa Girardi, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro
Snakebites have been recognized as a neglected public health problem in several tropical and subtropical countries. Bothrops snakebites frequently complicate with acute kidney injury (AKI) with relevant morbidity and mortality. To date, the only treatment available for Bothrops envenomation is the intravenous administration of antivenom despite its several limitations. Therefore, the study of novel therapies in Bothrops envenomation is compelling. The aim of this study was to evaluate the protective effect of Allopurinol (Allo) in an experimental model of Bothrops jararaca venom (BJ)-associated AKI...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29152044/structure-based-discovery-of-thiosemicarbazone-metalloproteinase-inhibitors-for-hemorrhage-treatment-in-snakebites
#10
Francis B Ferreira, Thiago M Pereira, Dayane L N Souza, Daiana S Lopes, Vitor Freitas, Veridiana M R Ávila, Arthur E Kümmerle, Carlos Mauricio R Sant'Anna
The venoms of snakes are composed by many toxins, which are responsible for various toxic effects including intense pain, bleeding disorders, and local tissue damage caused by hemorrhage and necrosis. The snake venom metalloproteinases (SVMPs) are proteolytic zinc-dependent enzymes acting in different hemostatic mechanisms. In this work, a structure-based molecular modeling strategy was used for the rational design, by means of a homology 3D model of an SVMP isolated from Bothrops pauloensis venom (BpMP-I), followed by synthesis and in vitro evaluation of new thiosemicarbazones as the first inhibitors of the B...
November 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29151420/-clinical-application-of-vsd-negative-pressure-aspiration-and-detoxification-in-severe-snake-bite
#11
Zhipeng Zheng, Gonglei Chen, Wei Liang, Xu Ji, Jing Yin, Meiling Liu, Wentao Chen, Yigang Yu, Wei Chen
OBJECTIVE: To assess the clinical efficacy of vacuum sealing drainage (VSD) in the treatment of mixed poisonous snake bite. METHODS: A prospective study was conducted. Forty-three snake bite patients by mixed poisonous snakes admitted to Department of Emergency of the 175th Hospital of People's Liberation Army from February 2015 to February 2017 were enrolled. All patients were divided into routine treatment group (n = 20) and VSD treatment group (n = 23) according to whether early incision decompression and using the VSD technique...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29147044/effective-polyvalent-affordable-antivenom-needed-to-treat-snakebite-in-nepal
#12
Bhola R Shrestha, Deb P Pandey, Krishna P Acharya, Chhabilal Thapa-Magar, Fahim Mohamed, Geoffrey K Isbister
No abstract text is available yet for this article.
October 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29142382/capillary-leak-syndrome-following-snakebite-envenomation
#13
REVIEW
V Udayabhaskaran, E T Arun Thomas, Bhagya Shaji
Capillary leak syndrome is a unique complication that follows Russell's viper envenomation. This syndrome has a very high fatality rate and is characterized by parotid swelling, chemosis, periorbital edema, hypotension, albuminuria, hypoalbuminemia, and hemoconcentration. This syndrome is frequently recognized from the southern parts of India, especially from the state of Kerala. It has been postulated that a vascular apoptosis inducing component of Russell's viper venom that is not neutralized by the commercially available anti-snake venom (ASV) is responsible for this complication as it occurs even after adequate doses of ASV administration in most cases...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29138643/interactions-of-desmethoxyyangonin-a-secondary-metabolite-from-renealmia-alpinia-with-human-monoamine-oxidase-a-and-oxidase-b
#14
Narayan D Chaurasiya, Francisco León, Yuanqing Ding, Isabel Gómez-Betancur, Dora Benjumea, Larry A Walker, Stephen J Cutler, Babu L Tekwani
Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4'-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29133665/a-rare-case-of-bilateral-tractional-retinal-detachment-following-snakebite
#15
Nicey Roy Thomas, Debmalya Das, Kumar Saurabh, Rupak Roy
A 13-year-old female presented with diminution of vision in both eyes for 3 months following snakebite. Best-corrected visual acuities were hand movement in both eyes. Fundoscopy showed vitreous hemorrhage, and B-scan ultrasonography revealed an underlying tractional retinal detachment (TRD) involving the macula in both eyes. Patient underwent 25-gauge pars plana vitrectomy in conjunction with belt buckling, endolaser, and silicone oil tamponade in the left eye. At 6 weeks postoperatively, best-corrected visual acuity of the left eye was noted to be 20/200 with settled TRD and attached retina...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29124975/ulnar-artery-pseudoaneurysm-and-compartment-syndrome-formation-after-snake-bite-to-the-left-forearm
#16
Lan Pin, Xie Lutao, Fang Weijun, Pan Feng, Chen Chaohui, Wu Jianrong
OBJECTIVE: To report the outcome of a patient who developed pseudoaneurysms and compartment syndrome after a Deinagkistrodon acutus snakebite. CASE REPORT: A 61-year-old man, bitten by Deinagkistrodon acutus in his left forearm, came to the hospital eight hours after the bite. Despite the use of antivenom and supportive therapy, the patient developed compartment syndrome of the left forearm, the tissue pressure was elevated and fasciotomy was arranged. During the initial surgery, part of the necrotic tissues was removed...
November 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29114379/mosquito-net-and-snakebite
#17
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29113958/comparison-of-two-jatropha-species-euphorbiaceae-used-popularly-to-treat-snakebites-in-northeastern-brazil-chemical-profile-inhibitory-activity-against-bothrops-erythromelas-venom-and-antibacterial-activity
#18
Juliana Félix-Silva, Jacyra A S Gomes, Júlia M Fernandes, Angela K C Moura, Yamara A S Menezes, Elizabeth C G Santos, Denise V Tambourgi, Arnóbio A Silva-Junior, Silvana M Zucolotto, Matheus F Fernandes-Pedrosa
ETHNOPHARMACOLOGICAL RELEVANCE: Jatropha species (Euphorbiaceae) are largely used in traditional medicine to treat different pathologies in Africa, Asia and Latin America. In Northeastern Brazilian folk medicine, several Jatropha species, such as Jatropha gossypiifolia L. and Jatropha mollissima (Pohl) Baill., are indistinctly used to treat snakebites. AIM OF THE STUDY: To compare two of the Brazilian most used Jatropha species for snakebites (J. gossypiifolia and J...
November 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29108023/health-seeking-behavior-following-snakebites-in-sri-lanka-results-of-an-island-wide-community-based-survey
#19
Dileepa Senajith Ediriweera, Anuradhani Kasturiratne, Arunasalam Pathmeswaran, Nipul Kithsiri Gunawardena, Shaluka Francis Jayamanne, David Griffith Lalloo, Hithanadura Janaka de Silva
INTRODUCTION: Sri Lanka has a population of 21 million and about 80,000 snakebites occur annually. However, there are limited data on health seeking behavior following bites. We investigated the effects of snakebite and envenoming on health seeking behavior in Sri Lanka. METHODS: In a community-based island-wide survey conducted in Sri Lanka 44,136 households were sampled using a multistage cluster sampling method. An individual who reported experiencing a snakebite within the preceding 12 months was considered a case...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29107670/new-findings-from-the-first-transcriptome-of-the-bothrops-moojeni-snake-venom-gland
#20
Fernanda Gobbi Amorim, Romualdo Morandi-Filho, Patricia Tieme Fujimura, Carlos Ueira-Vieira, Suely Vilela Sampaio
Snakebites are a serious health problem in tropical countries. In Brazil, the genus Bothrops (Viperidae family) causes most of the ophidic accidents, characterized by proteolysis and haemorrhage. Snake venoms are rich sources of toxins with great therapeutic and biotechnological potential and omics approaches is a valuable tool for identification of new bioactive components in the venom. In this study, we described the first transcriptome of the venom gland of Bothrops moojeni snake, using the next-generation sequencing with the Illumina platform...
October 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
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