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https://www.readbyqxmd.com/read/28077331/physiological-behavioral-changes-induced-by-a-fraction-with-antitumor-cleronade-diterpenes-from-an-atlantic-forest-brazilian-plant-and-computational-intermolecular-interactions-with-neuron-receptors
#1
Éverton José Ferreira de Araújo, Antônia Amanda Cardoso de Almeida, Oskar Almeida Silva, Iwyson Henrique Fernandes da Costa, Luis Mário Rezende Júnior, Francisco das Chagas Alves Lima, Luciano da Silva Lopes, Alberto José Cavalheiro, Paulo Michel Pinheiro Ferreira
ETHNOPHARMACOLOGICAL RELEVANCE: Casearia sylvestris is a medicinal plant traditionally used to treat snakebites, wounds, inflammation and gastric ulcers and scientific supports for have demonstrated its antitumor, antihyperlipidemic and antiparasitic properties. AIM OF THE STUDY: To assess the effects of a fraction with casearins (FC) on adult mice using classical experimental models of animal behavior and theoretical calculations to verify the interaction of Casearin X (Cas X) with neuron receptors...
January 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28035960/a-survey-of-snakebite-knowledge-among-field-forces-in-china
#2
Chulin Chen, Li Gui, Ting Kan, Shuang Li, Chen Qiu
A snakebite is a neglected extrinsic injury associated with high morbidity and global mortality. Members of Chinese field forces are at high risk of snakebites, and their perception and knowledge of snakebites are unknown. The aim of this study is to assess perception and knowledge of snakebites in field forces in southeast China; Methods: A cross-sectional questionnaire-based survey was conducted in July 2016. A total of 216 field force members participated in this study; Results: A total of 10.3% had experienced snakebites and 86...
December 26, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28001213/an-overview-of-bothrops-erythromelas-venom
#3
Neriane Monteiro Nery, Karla Patrícia Luna, Carla Freire Celedônio Fernandes, Juliana Pavan Zuliani
This review discusses studies on the venom of Bothrops erythromelas published over the past 36 years. During this period, many contributions have been made to understand the venomous snake, its venom, and its experimental and clinical effects better. The following chronological overview is based on 29 articles that were published between 1979 and 2015, with emphasis on diverse areas. The complexity of this task demands an integration of multidisciplinary research tools to study toxinology. This science is in need of renewed conceptual and experimental platforms aimed at obtaining a profound understanding of the highly complex pathophysiology of snakebite envenoming and toxins isolated from snakes...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27993635/the-potential-of-aqueous-extracts-of-bellucia-dichotoma-cogn-melastomataceae-to-inhibit-the-biological-activities-of-bothrops-atrox-venom-a-comparison-of-specimens-collected-in-the-states-of-par%C3%A3-and-amazonas-brazil
#4
Valéria Mourão de Moura, Luana Yamille Andrade de Souza, Noranathan da Costa Guimarães, Ilia Gilmara Carvalho Dos Santos, Patrícia Danielle Oliveira de Almeida, Ricardo Bezerra de Oliveira, Rosa Helena Veras Mourão, Maria Cristina Dos-Santos
ETHNOPHARMACOLOGICAL IMPORTANCE: The effectiveness of aqueous extract of Bellucia dichotoma Cogn. (Melastomataceae) specimems collected in Santarém, PA, against some biological activities of Bothrops atrox venom (BaV) has been scientifically proven. Here, we analyzed the components and assessed the anti-snakebite potential of aqueous extracts of bark of B. dichotoma collected in Manaus, AM, (AEBd-MAO) and Santarém, PA, (AEBd-STM), both in Brazil. MATERIALS AND METHODS: The phytochemical profiles of the aqueous extracts were identified using thin layer chromatography (TLC), and the concentrations of phenolics were determined by colorimetric assay...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27942175/snakebite-mediated-acute-kidney-injury-prognostic-predictors-oxidative-and-carbonyl-stress-a-prospective-study
#5
P Mukhopadhyay, R Mishra, D Mukherjee, R Mishra, M Kar
Snake bite is an occupational hazard in India and important preventable cause of acute kidney injury (AKI). This study was done to estimate the magnitude of snakebite-induced AKI (SAKI) who required renal replacement therapy, prognostic predictors, and final outcome, and to measure the oxidative and carbonyl stress (CS) level in SAKI patient who underwent hemodialysis (HD). All SAKI patients dialyzed between April 2010 and July 2011 in NRS Medical College were included. Demographical, clinical, and biochemical data were analyzed, and patients are followed to discharge or death...
November 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27940763/childhood-victims-of-snakebites-2000-2013
#6
Joann Schulte, Kristina Domanski, Eric Anthony Smith, Annelle Menendez, Kurt C Kleinschmidt, Brett A Roth
BACKGROUND: Snakebites are not a reportable condition (to state health departments), and 1 major assessment of US children with snakebites was published 50 years ago. Increasing urbanization, population shifts south and west, newer antivenom therapy, and the importation of exotic snakes may have changed snakebites. Poison control centers are often consulted on treatment and collect surveillance data. METHODS: Generic codes for venomous, nonvenomous, and unknown snakebites were used to characterize victims aged ≤18 years reported to US poison control centers between 2000 and 2013...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27930893/severe-snakebite-envenoming-in-intensive-care
#7
REVIEW
Jiří Valenta, Zdeněk Stach, Pavel Michálek
Snakebites by exotic venomous snakes can cause serious or even life-threatening envenoming. In Europe and North America most victims are breeders, with a few snakebites from wild native American rattlesnakes. The envenomed victims may present in organ and/or system failure with muscle paralysis, respiratory failure, circulatory instability, acute kidney injury, severe coagulation disorder, and local disability - compartment syndrome and necrosis. Best managed by close collaboration between clinical toxicology and intensive care, most severe envenomings are managed primarily by intensive care physicians...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27903075/australian-taipan-oxyuranus-spp-envenoming-clinical-effects-and-potential-benefits-of-early-antivenom-therapy-australian-snakebite-project-asp-25
#8
Christopher I Johnston, Nicole M Ryan, Margaret A O'Leary, Simon G A Brown, Geoffrey K Isbister
CONTEXT: Taipans (Oxyuranus spp.) are medically important venomous snakes from Australia and Papua New Guinea. The objective of this study was to describe taipan envenoming in Australian and its response to antivenom. METHODS: Confirmed taipan bites were recruited from the Australian Snakebite Project. Data were collected prospectively on all snakebites, including patient demographics, bite circumstances, clinical effects, laboratory results, complications and treatment...
November 30, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27890774/inhibition-of-local-effects-induced-by-bothrops-erythromelas-snake-venom-assessment-of-the-effectiveness-of-brazilian-polyvalent-bothropic-antivenom-and-aqueous-leaf-extract-of-jatropha-gossypiifolia
#9
Juliana Félix-Silva, Jacyra A S Gomes, Jacinthia B Xavier-Santos, Júlia G R Passos, Arnóbio A Silva-Junior, Denise V Tambourgi, Matheus F Fernandes-Pedrosa
Bothrops erythromelas is a snake of medical importance responsible for most of the venomous incidents in Northeastern Brazil. However, this species is not included in the pool of venoms that are used in the Brazilian polyvalent bothropic antivenom (BAv) production. Furthermore, it is well known that antivenom therapy has limited efficacy against venom-induced local effects, making the search for complementary alternatives to treat snakebites an important task. Jatropha gossypiifolia is a medicinal plant widely indicated in folk medicine as an antidote for snakebites, whose effectiveness against Bothrops jararaca venom (BjV) has been previously demonstrated in mice...
January 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27888371/protective-effect-of-the-sulfated-agaran-isolated-from-the-red-seaweed-laurencia-aldingensis-against-toxic-effects-of-the-venom-of-the-snake-lachesis-muta
#10
Ana Cláudia Rodrigues da Silva, Luciana Garcia Ferreira, Maria Eugênia Rabello Duarte, Mutue Toyota Fujii, Eladio Flores Sanchez, Miguel Daniel Noseda, André Lopes Fuly
Snakebite is a serious occupational hazard affecting mainly rural populations of tropical and subtropical developing countries. Lachesis muta (Bushmaster) bites are extremely serious but are rarely reported in the literature. Bushmaster envenomings are characterized by intense local pain, edema, neurotoxicity, hypotension, local hemorrhage, and dramatic systemic alterations. Antivenom treatment has regularly been used for more than a century; however, it fails to neutralize local tissue damage and hemorrhage, leading to morbidity or disabilities in victims...
November 25, 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27886134/priority-actions-and-progress-to-substantially-and-sustainably-reduce-the-mortality-morbidity-and-socioeconomic-burden-of-tropical-snakebite
#11
Robert A Harrison, José María Gutiérrez
The deliberations and conclusions of a Hinxton Retreat convened in September 2015, entitled "Mechanisms to reverse the public health neglect of snakebite victims" are reported. The participants recommended that the following priority actions be included in strategies to reduce the global impact of snake envenoming: (a) collection of accurate global snakebite incidence, mortality and morbidity data to underpin advocacy efforts and help design public health campaigns; (b) promotion of (i) public education prevention campaigns; (ii) transport systems to improve access to hospitals and (iii) establishment of regional antivenom-efficacy testing facilities to ensure antivenoms' effectiveness and safety;...
November 24, 2016: Toxins
https://www.readbyqxmd.com/read/27886127/viperid-envenomation-wound-exudate-contributes-to-increased-vascular-permeability-via-a-damps-tlr-4-mediated-pathway
#12
Alexandra Rucavado, Carolina A Nicolau, Teresa Escalante, Junho Kim, Cristina Herrera, José María Gutiérrez, Jay W Fox
Viperid snakebite envenomation is characterized by inflammatory events including increase in vascular permeability. A copious exudate is generated in tissue injected with venom, whose proteomics analysis has provided insights into the mechanisms of venom-induced tissue damage. Hereby it is reported that wound exudate itself has the ability to induce increase in vascular permeability in the skin of mice. Proteomics analysis of exudate revealed the presence of cytokines and chemokines, together with abundant damage associated molecular pattern molecules (DAMPs) resulting from both proteolysis of extracellular matrix and cellular lysis...
November 24, 2016: Toxins
https://www.readbyqxmd.com/read/27885284/snakebite-in-nepal-neglected-public-health-challenge
#13
K B Karki
No abstract text is available yet for this article.
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27871786/ischemic-brain-infarcts-and-intracranial-haemorrhages-following-russell-s-viper-daboia-russelii-bite-in-sri-lanka
#14
R M M K Namal Rathnayaka, S A M Kularatne, K D M Kumarasinghe, Janaka Ranaweera, P E A Nishanthi Ranathunga
Snakebite is an important medical problem in Sri Lanka. Of the deadly venomous snakes, Russell's viper (Daboia russelii) is widely distributed and responsible for most of the fatalities of snakebite in the country. It is not uncommon to see atypical manifestations in Russell's viper bite. We report the events of intracranial haemorrhages and multiple ischemic brain infarcts following Russell's viper (Daboia russelii) bite of a previously healthy 43-years-old male who succumbed to envenoming.
January 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27867095/identification-of-snake-venom-allergens-by-two-dimensional-electrophoresis-followed-by-immunoblotting
#15
Yujing Hu, Liming Yang, Haiwei Yang, Shaoheng He, Ji-Fu Wei
This allergic reaction to snake venom was described to occur in patients after recurrent exposure through bites in amateur and professional snake handlers, which might be underestimated and contribute to fatal snakebites in victim, independently from the toxicity of the venom itself. Few allergens were identified from snake venoms by normal SDS-PAGE, which cannot separate the snake venom completely. In the present study, we identified nine potential allergens by two-dimensional (2D) electrophoresis followed by immunoblotting (named as allergenomics) in Protobothrops mucrosquamatus venom...
January 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27861683/-hospitalizations-due-to-external-causes-involving-contact-with-animals-in-a-general-hospital-in-the-interior-of-bahia-state-brazil-2009-2011
#16
Érica Assunção Carmo, Adriana Alves Nery, Cleber Souza de Jesus, Cezar Augusto Casotti
OBJECTIVE: to describe the characteristics of hospitalizations due to external causes involving contact with animals in a general hospital in the interior of Bahia State (BA), Brazil, from 2009 to 2011. METHODS: this was a descriptive study using data on hospital admissions in Jequié-BA. RESULTS: there were 246 admissions owing to accidents involving contact with animals, especially venomous ones (83.3% snake venom, and 6.5% scorpion venom); most involved male victims (66...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27847818/aqueous-leaf-extract-of-jatropha-mollissima-pohl-bail-decreases-local-effects-induced-by-bothropic-venom
#17
Jacyra Antunes Dos Santos Gomes, Juliana Félix-Silva, Júlia Morais Fernandes, Juliano Geraldo Amaral, Norberto Peporine Lopes, Eryvaldo Sócrates Tabosa do Egito, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus. The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost. Thus, the search for alternative therapies to treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27824133/high-throughput-immuno-profiling-of-mamba-dendroaspis-venom-toxin-epitopes-using-high-density-peptide-microarrays
#18
Mikael Engmark, Mikael R Andersen, Andreas H Laustsen, Jigar Patel, Eric Sullivan, Federico de Masi, Christian S Hansen, Jens V Kringelum, Bruno Lomonte, José María Gutiérrez, Ole Lund
Snakebite envenoming is a serious condition requiring medical attention and administration of antivenom. Current antivenoms are antibody preparations obtained from the plasma of animals immunised with whole venom(s) and contain antibodies against snake venom toxins, but also against other antigens. In order to better understand the molecular interactions between antivenom antibodies and epitopes on snake venom toxins, a high-throughput immuno-profiling study on all manually curated toxins from Dendroaspis species and selected African Naja species was performed based on custom-made high-density peptide microarrays displaying linear toxin fragments...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27820835/snakebite-envenoming-a-combined-density-equalizing-mapping-and-scientometric-analysis-of-the-publication-history
#19
David A Groneberg, Victoria Geier, Doris Klingelhöfer, Alexander Gerber, Ulrich Kuch, Beatrix Kloft
Estimates suggest that more than 25,000 to 125,000 people die annually from snakebite envenomation worldwide. In contrast to this major disease burden, thorough bibliometric studies do not exist so far that illustrate the overall research activity over a long time span. Therefore, the NewQIS-platform conducted an analysis on snakebite envenoming using the Thomson Reuters database Web of Science. To determine and assess changes regarding the scientific activities and to specifically address the more recent situation we analyzed two time intervals (t)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27814368/chronic-musculoskeletal-disabilities-following-snake-envenoming-in-sri-lanka-a-population-based-study
#20
Subashini Jayawardana, Ariaranee Gnanathasan, Carukshi Arambepola, Thashi Chang
BACKGROUND: Snakebite is a major public health problem in agricultural communities in the tropics leading to acute local and systemic impairments with resultant disabilities. Snakebite related long-term musculoskeletal disabilities have been a neglected area of research. We conducted a population-based, cross-sectional study in an agricultural community to describe the chronic musculoskeletal disabilities of snake envenoming. METHODOLOGY/PRINCIPAL FINDINGS: A sample representative of residents of a single district in a region of high incidence of snake envenoming was recruited to identify ever snakebite victims...
November 2016: PLoS Neglected Tropical Diseases
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