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https://www.readbyqxmd.com/read/28811229/necrotizing-fasciitis-following-venomous-snakebites-in-a-tertiary-hospital-of-southwest-taiwan
#1
Yao-Hung Tsai, Wei-Hsiu Hsu, Kuo-Chin Huang, Pei-An Yu, Chi-Lung Chen, Liang Tseng Kuo
BACKGROUND: Necrotizing fasciitis following venomous snakebites is uncommon. The purpose of this study was to describe the initial clinical features of necrotizing fasciitis after snakebites, and to identify the risk factors for patients with cellulitis who later developed necrotizing fasciitis. METHODS: Sixteen patients with surgically-confirmed necrotizing fasciitis and 25 patients diagnosed with cellulitis following snakebites were retrospectively reviewed over a 6-year period...
August 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28807018/the-neglected-burden-of-snakebites-in-cameroon-a-review-of-the-epidemiology-management-and-public-health-challenges
#2
Joel Noutakdie Tochie, Mazou N Temgoua, Tsi Njim, Danwang Celestin, Ronni Tankeu, Njinkeng J Nkemngu
OBJECTIVES: Snakebite is an underestimated medical and surgical emergency in developing countries responsible for a high disease burden. Optimal management of snake envenomation in these resource-limited settings is precluded by several public health challenges. In this review, we discuss the disease burden of snakebites in Cameroon and the public health challenges of its management in view of making recommendations essential for policy-making. MEDLINE, African Journals Online and Google Scholar were searched from January 1990 to February 2017 for studies addressing snakebite in Cameroon...
August 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28804495/snakebite-envenomation-turns-again-into-a-neglected-tropical-disease
#3
Jean-Philippe Chippaux
On June 9(th), 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches. It should also expand the accessibility of antivenoms. Let us hope that it also leads to cooperation among stakeholders, aiming at improving the management of snakebites in developing countries.
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28799310/venomous-snake-bite-in-india-why-do-50-000-indians-die-every-year
#4
Jaideep C Menon, Joseph K Joseph, Romulus E Whitaker
Snakebite is an occupational hazard causing considerable morbidity and mortality worldwide, particularly so in tropical countries like India. An estimated 50,000 Indians die due to venomous snakebite every year, seventy percent of whom are males between the ages of 20 to 50 years. Along with the associated morbidity and mortality, snakebite leads to a significant financial burden on the victim, both by way of hospital bills and labour hours lost. Snakebite is also a cause for considerable psychological stress among survivors...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28793021/the-epidemiology-of-snakebite-in-the-rio-grande-do-norte-state-northeastern-brazil
#5
Aluska Vieira Tavares, Kaliany Adja Medeiros de Araújo, Michael Radan de Vasconcelos Marques, Alecxandro Alves Vieira, Renner de Souza Leite
This report is a retrospective study of the epidemiology of snakebite cases recorded from 2007 to 2014 in the Rio Grande do Norte State, northeastern Brazil. Data was collected from the Injury Notification Information System database of the Health Department of Rio Grande do Norte. A total of 3,019 cases were studied. Cases were distributed over all months of the period studied and occurred mainly in rural areas. Snakes of the genus Bothrops, Crotalus, Micrurus, Lachesis and non-venomous snakes were responsible for 1,507, 185, 52, 6 and 673 cases, respectively...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28764628/snakebites-reducing-their-international-impact
#6
David A Warrell
No abstract text is available yet for this article.
August 7, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28764620/the-australian-snakebite-project-2005-2015-asp-20
#7
MULTICENTER STUDY
Christopher I Johnston, Nicole M Ryan, Colin B Page, Nicholas A Buckley, Simon Ga Brown, Margaret A O'Leary, Geoffrey K Isbister
OBJECTIVE: To describe the epidemiology, treatment and adverse events after snakebite in Australia. DESIGN: Prospective, multicentre study of data on patients with snakebites recruited to the Australian Snakebite Project (2005-2015) and data from the National Coronial Information System. Setting, participants: Patients presenting to Australian hospitals with suspected or confirmed snakebites from July 2005 to June 2015 and consenting to participation. MAIN OUTCOME MEASURES: Demographic data, circumstances of bites, clinical effects of envenoming, results of laboratory investigations and snake venom detection kit (SVDK) testing, antivenom treatment and adverse reactions, time to discharge, deaths...
August 7, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28759785/in%C3%A2-vitro-cleavage-of-bioactive-peptides-by-peptidases-from-bothrops-jararaca-venom-and-its-neutralization-by-bothropic-antivenom-produced-by-butantan-institute-major-contribution-of-serine-peptidases
#8
Alexandre Kazuo Kuniyoshi, Roberto Tadashi Kodama, Luis Henrique Ferreira Moraes, Bruno Duzzi, Leo Kei Iwai, Ismael Feitosa Lima, Daniela Cajado-Carvalho, Fernanda Vieira Portaro
In Brazil, envenomation by Bothrops pitvipers is responsible for over 73% of snakebites, and their venom is a rich source of proteolytic enzymes. Most studies have demonstrated that Bothrops jararaca venom acts on macromolecular substrates, causing an imbalance in the victim's hemostatic system. In contrast, fewer studies have examined the proteolytic activity on small molecules such as peptides. In this study, we used a set of bioactive peptides (insulin B chain, Met-enkephalin, Leu-enkephalin, neuropeptide Y, peptide YY, pancreatic polypeptide, substance P and somatostatin) to identify new peptide substrates for the metallopeptidases and serine peptidases from the B...
July 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28759578/heterologous-expression-of-the-antimyotoxic-protein-dm64-in-pichia-pastoris
#9
Saulo Martins Vieira, Surza Lucia Gonçalves da Rocha, Ana Gisele da Costa Neves-Ferreira, Rodrigo Volcan Almeida, Jonas Perales
Snakebite envenomation is a neglected condition that constitutes a public health problem in tropical and subtropical countries, including Brazil. Interestingly, some animals are resistant to snake envenomation due to the presence of inhibitory glycoproteins in their serum that target toxic venom components. DM64 is an acidic glycoprotein isolated from Didelphis aurita (opossum) serum that has been characterized as an inhibitor of the myotoxicity induced by bothropic toxins bearing phospholipase A2 (PLA2) structures...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28755820/prolonged-coagulopathy-ecchymoses-and-microangiopathic-hemolytic-anemia-following-hump-nosed-pit-viper-hypnale-hypnale-bite-in-sri-lanka
#10
Rathnayaka Mudiyanselage M K Namal Rathnayaka, Senanayake A M Kularatne, Anusha Nishanthi Ranathunga, Mahinda Kumarasinghe, Jayantha Rajapakse, Shirani Ranasinghe
A 74-year-old previously healthy woman was bitten by a hump-nosed pit viper (Hypnale hypnale) at dusk causing incoagulable blood lasting for 6 days. Further, she developed ecchymoses over her forearms, upper arms, hands, and lower back on day 4 after the snakebite, and microangiopathic hemolytic anemia (MAHA). Features of this nature are rare after hump-nosed pit viper bite.
July 26, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28751219/structural-studies-with-bnsp-7-reveal-an-atypical-oligomeric-conformation-compared-to-phospholipases-a2-like-toxins
#11
Lino Fernando G de Lima, Rafael J Borges, Maria Alejandra Viviescas, Carlos A H Fernandes, Marcos R M Fontes
There are 2.5 million cases of snakebite per year and approximately 100,000 at 150,000 deaths. Thus, it is considered an important public health problem by the World Health Organization. Snakes from the Bothrops genus may cause severe local effects in the victims, so it is important to develop inhibitors to treat local effects in patients. In addition, approximately 30 different species of bothropic snakes have been described that may present differences in their venom composition. Small structural differences in the venom proteins may result in different ligands binding...
July 24, 2017: Biochimie
https://www.readbyqxmd.com/read/28746861/investigation-of-the-inhibitory-potential-of-phospholipase-a2-inhibitor-gamma-from-sinonatrix-annularis-to-snake-envenomation
#12
Shengwei Xiong, Yunyun Luo, Lipeng Zhong, Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang
SaPLIγ is a novel gamma phospholipase A2 inhibitor (PLI) recently isolated from Sinonatrix annularis, a Chinese endemic non-venomous snake. To explore the neutralization effects of saPLIγ in snakebite envenomation, a dose equivalent to LD50 of Deinagkistrodon acutus, Agkistrodon halys and Naja atra venom with/without saPLIγ was inoculated into the gastrocnemius muscle of female Kunming mice. The ability of saPLIγ to inhibit myonecrosis and systemic toxicity were evaluated through investigations of muscle histopathology, and determination of the serum levels of creatine kinase (CK), lactate dehydrogenase isoenzyme1 (LDH1) and aspartate transferase (AST)...
July 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28733908/assessment-of-cultivable-oral-bacterial-flora-from-important-venomous-snakes-of-india-and-their-antibiotic-susceptibilities
#13
Innus K Shaikh, Prashant P Dixit, Balasaheb S Pawade, Mugdha Potnis-Lele, Babasaheb P Kurhe
Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities...
July 21, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28719273/bungarus-multicinctus-multicinctus-snakebite-in-taiwan
#14
Yan-Chiao Mao, Po-Yu Liu, Liao-Chun Chiang, Shu-Chen Liao, Hung-Yuan Su, Szu-Yin Hsieh, Chen-Chang Yang
AbstractAlthough specific antivenom is available in Taiwan, respiratory failure and general pain frequently accompany Bungarus multicinctus envenomation and there have been few reports on the management of B. multicinctus envenomation. We retrospectively analyzed 44 cases of B. multicinctus bite admitted to Taichung Veterans General Hospital (VGH) or to Taipei VGH. Demographic data, treatment, and outcome of patients with and without respiratory failure were compared. In this study, 20.5% patients had bites without noticeable signs or symptoms of significant envenoming, 27...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28708892/cross-recognition-of-a-pit-viper-crotalinae-polyspecific-antivenom-explored-through-high-density-peptide-microarray-epitope-mapping
#15
Mikael Engmark, Bruno Lomonte, José María Gutiérrez, Andreas H Laustsen, Federico De Masi, Mikael R Andersen, Ole Lund
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies purified from the blood of hyper-immunized animals. Knowledge on antibody recognition sites (epitopes) on snake venom proteins is limited, but may be used to provide molecular level explanations for antivenom cross-reactivity. In turn, this may help guide antivenom development by elucidating immunological biases in existing antivenoms. In this study, we have identified and characterized linear elements of B-cell epitopes from 870 pit viper venom protein sequences by employing a high-throughput methodology based on custom designed high-density peptide microarrays...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28703020/epidemiology-and-clinical-outcomes-of-snakebite-in-the-elderly-a-toxic-database-study
#16
Meghan B Spyres, Anne-Michelle Ruha, Kurt Kleinschmidt, Rais Vohra, Eric Smith, Angela Padilla-Jones
INTRODUCTION: Epidemiologic studies of snakebites in the United States report typical victims to be young men. Little is known regarding other demographics including children and the elderly. The objective of this study was to describe the epidemiology and clinical manifestations of snake bite in elderly patients reported to the ToxIC (Toxicology Investigators Consortium) North American Snakebite Registry (NASBR) Methods: This was a multicenter analysis of a prospectively collected cohort of patients with snakebite reported to the ToxIC NASBR between 1 January 2013 and 31 December 2015...
July 13, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28698056/daboia-vipera-palaestinae-envenomation-in-horses-clinical-and-hematological-signs-risk-factors-for-mortality-and-construction-of-a-novel-severity-scoring-system
#17
Sharon Tirosh-Levy, Reut Solomovich, Judith Comte, Gila A Sutton, Amir Steinman
Daboia palaestinae is the most common venomous snake in Israel and an important cause of envenomations in humans and animals. Although specific antivenom is produced from horses, little documentation exists regarding the characteristics of envenomed horses. This survey was constructed to describe the clinical, hematological and biochemical characteristics of D. palaestinae envenomation in horses, to identify risk factors for fatality and to construct a prognostic snakebite severity scale (SSS) to be used by veterinarians in the field...
July 8, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28692641/poor-efficacy-of-preemptive-amoxicillin-clavulanate-for-preventing-secondary-infection-from-bothrops-snakebites-in-the-brazilian-amazon-a-randomized-controlled-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Jacqueline A G Sachett, Iran Mendonça da Silva, Eliane Campos Alves, Sâmella S Oliveira, Vanderson S Sampaio, Fábio Francesconi do Vale, Gustavo Adolfo Sierra Romero, Marcelo Cordeiro Dos Santos, Hedylamar Oliveira Marques, Mônica Colombini, Ana Maria Moura da Silva, Fan Hui Wen, Marcus V G Lacerda, Wuelton M Monteiro, Luiz C L Ferreira
BACKGROUND: Secondary bacterial infections from snakebites contribute to the high complication rates that can lead to permanent function loss and disabilities. Although common in endemic areas, routine empirical prophylactic use of antibiotics aiming to prevent secondary infection lacks a clearly defined policy. The aim of this work was to estimate the efficacy of amoxicillin clavulanate for reducing the secondary infection incidence in patients bitten by Bothrops snakes, and, secondarily, identify risk factors for secondary infections from snakebites in the Western Brazilian Amazon...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28683119/the-socio-economic-burden-of-snakebite-in-sri-lanka
#19
Anuradhani Kasturiratne, Arunasalam Pathmeswaran, A Rajitha Wickremasinghe, Shaluka F Jayamanne, Andrew Dawson, Geoff K Isbister, Hithanadura Janaka de Silva, David G Lalloo
BACKGROUND: Snakebite is a major problem affecting the rural poor in many of the poorest countries in the tropics. However, the scale of the socio-economic burden has rarely been studied. We undertook a comprehensive assessment of the burden in Sri Lanka. METHODS: Data from a representative nation-wide community based household survey were used to estimate the number of bites and deaths nationally, and household and out of pocket costs were derived from household questionnaires...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28673600/on-the-chemotherapeutic-agents-localization-in-tissue-by-means-of-snake-venoms
#20
Oleksii S Rukhlenko, Georgy Th Guria, Andrey I Vorobiev
The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a tumour can be exposed to high-dose therapeutic influence but the target organ may be isolated from the rest of circulatory system only for a relatively short period of time. During systemic injection of anti-tumour agents dose limitations are dictated by side toxicity danger...
July 2017: Medical Hypotheses
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