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https://www.readbyqxmd.com/read/29024771/development-of-dot-elisa-for-the-detection-of-venoms-of-major-indian-venomous-snakes
#1
Innus K Shaikh, Prashant P Dixit, Balasaheb S Pawade, Indrasen G Waykar
India remained an epicenter for the snakebite-related mortality and morbidities due to widespread agricultural activities across the country and a considerable number of snakebites offended by Indian cobra (Naja naja), common krait (Bungarus caeruleus), Russell's viper (Daboia russelii), and saw-scaled viper (Echis carinatus). Presently, there is no selective test available for the detection of snake envenomation in India before the administration of snake antivenin. Therefore, the present study aimed to develop rapid, sensitive assay for the management of snakebite, which can detect venom, responsible snake species and serve as a tool for the reasonable administration of snake antivenin, which have scarcity across the world...
October 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28990237/dereplication-by-hplc-dad-esi-ms-ms-and-screening-for-biological-activities-of-byrsonima-species-malpighiaceae
#2
Karina Fraige, Alessandra Cristina Dametto, Maria Luiza Zeraik, Larissa de Freitas, Amanda Correia Saraiva, Alexandra Ivo Medeiros, Ian Castro-Gamboa, Alberto José Cavalheiro, Dulce Helena S Silva, Norberto Peporine Lopes, Vanderlan S Bolzani
INTRODUCTION: Byrsonima species have been used in the treatment of gastrointestinal and gynecological inflammations, skin infections and snakebites. Based on their biological activities, it is important to study other organisms from this genus and to identify their metabolites. OBJECTIVES: To determine the metabolic fingerprinting of methanol and ethyl acetate extracts of four Byrsonima species (B. intermedia, B. coccolobifolia, B. verbascifolia and B. sericea) by HPLC-DAD-ESI-MS/MS and evaluate their in vitro antioxidant, anti-glycation, anti-inflammatory and cytotoxic activities...
October 9, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28980622/snakebite-envenoming
#3
José María Gutiérrez, Juan J Calvete, Abdulrazaq G Habib, Robert A Harrison, David J Williams, David A Warrell
This corrects the article DOI: 10.1038/nrdp.2017.63.
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28977188/-safety-profile-of-heterologous-serum-produced-by-the-butantan-institute-in-s%C3%A3-o-paulo-sp-brazil-from-2012-to-2015
#4
Vera Lúcia Gattás, Patrícia Emília Braga, Marcelo Eiji Koike, Maria Beatriz Lucchesi, Alexander Roberto Precioso
OBJECTIVE: to describe the safety profile of the heterologous serum produced by the Butantan Institute (BI) of São Paulo-SP, Brazil. METHODS: a descriptive study of adverse events (AEs) post-exposure to serum produced by the BI, encoded in the medical terminology of the Medical Dictionary for Regulatory Activities (MedDRA), and spontaneously reported to BI from 2012 to 2015. RESULTS: 52 individuals reported AEs, mainly related to Bothrops antivenom (n=11), diphtheria antitoxin (n=9) and unspecified snakebite serum (n=9); a mean of 3...
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28975491/the-epidemiology-clinical-course-and-management-of-snakebites-in-the-north-american-snakebite-registry
#5
Anne-Michelle Ruha, Kurt C Kleinschmidt, Spencer Greene, Meghan B Spyres, Jeffrey Brent, Paul Wax, Angela Padilla-Jones, Sharan Campleman
The American College of Medical Toxicology established the North American Snakebite Registry (NASBR), a national database of detailed, prospectively collected information regarding snake envenomation in the United States, in 2013. This report describes the epidemiology, clinical course, and management of snakebites in the NASBR. All cases entered into the NASBR between January 1, 2013 and December 31, 2015 were identified. Descriptive statistics are used to report results. Fourteen sites in 10 states entered 450 snakebites...
October 3, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28965753/leishmania-mexicana-cell-death-achieved-by-cleoserrata-serrata-jacq-iltis-learning-from-maya-healers
#6
Lorena Noemi Alamilla-Fonseca, José Delgado-Domínguez, Jaime Zamora-Chimal, Rocely Buenaventura Cervantes-Sarabia, Adelina Jiménez-Arellanes, José Fausto Rivero-Cruz, Ingeborg Becker
ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Cleoserrata serrata (Jacq.) Iltis are widely used in South-Central Mexico to treat wounds and bacterial skin infections and in Panama by Kuna, Ngöbe-Buglé, and Teribe Indians for tropical warm baths and by Kunas in the form of "Ina kuamakalet" for snakebites. AIMS OF THE STUDY: To evaluate the effect of Cleoserrata serrata extract on growth and viability of L. mexicana amastigotes and promastigotes in vitro, as well as on bacteria that usually co-infect skin ulcers...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28962866/in-vitro-metabolism-of-4-5-dimethoxycanthin-6-one-by-human-liver-microsomes-and-its-inhibition-on-human-cyp1a2
#7
Xiaolei Miao, Jiaojiao You, Junjun Wang, Yong Chen
AIMS: P. quassioides is a traditional Chinese medicine used for the treatment of gastroenteritis, snakebite, infection and hypertension in China. 4, 5-dimethoxycanthin-6-one is one of the main active canthinone alkaloid isolated from P. quassioides. The aim of this work was to identify the cytochrome P (CYP) 450 enzymes responsible for the metabolism of 4, 5-dimethoxycanthin-6-one (DCO) and to evaluate the inhibitory effect of DCO on CYP activity in human liver microsomes (HLM) in vitro...
September 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28959667/a-hospital-based-epidemiological-study-of-snakebite-in-paschim-medinipur-district-west-bengal-india
#8
Sumana Sarkhel, Rituparna Ghosh, Koushik Mana, Kripasindhu Gantait
OBJECTIVE: Snakebite is a serious medical problem in Paschim Medinipur district, West Bengal, India. In the present study, hospital based data on snakebite cases and deaths were collected from 10 blocks of the district to obtain a picture of this neglected public health issue. METHODS: Retrospective data of snakebite and deaths from 2012 to 2016 was collected from the 5 Rural hospitals (RH) and 5 Block level Primary Health Centres(BPHC) of the ten blocks of Paschim Medinipur district in a prescribed format addressing issues including the demographic factors regarding the victims, seasonal pattern, history of snakebite in previous 5 years, outcome of the bite, any reporting of death...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28953092/the-effects-of-mucuna-pruriens-extract-on-histopathological-and-biochemical-features-in-the-rat-model-of-ischemia
#9
Vanishri S Nayak, Nitesh Kumar, Antony S D'Souza, Sunil S Nayak, Sri P Cheruku, K Sreedhara Ranganath Pai
Stroke is considered to be one of the most important causes of death worldwide. Global ischemia causes widespread brain injury and infarctions in various regions of the brain. Oxidative stress can be considered an important factor in the development of tissue damage, which is caused because of arterial occlusion with subsequent reperfusion. Kapikacchu or Mucuna pruriens, commonly known as velvet bean, is well known for its aphrodisiac activities. It is also used in the treatment of snakebites, depressive neurosis, and Parkinson's disease...
September 25, 2017: Neuroreport
https://www.readbyqxmd.com/read/28951306/anti-platelet-aggregation-activity-of-two-novel-acidic-asp49-phospholipases-a2-from-bothrops-brazili-snake-venom
#10
Juliana C Sobrinho, Anderson M Kayano, Rodrigo Simões-Silva, Jorge J Alfonso, Ana F Gomez, Maria C Vega Gomez, Fernando B Zanchi, Laura A Moura, Vivian R Souza, André L Fuly, Eliandre de Oliveira, Saulo L da Silva, José R Almeida, Juliana P Zuliani, Andreimar M Soares
Phospholipases A2 (PLA2s) are important enzymes present in snake venoms and are related to a wide spectrum of pharmacological effects, however the toxic potential and therapeutic effects of acidic isoforms have not been fully explored and understood. Due to this, the present study describes the isolation and biochemical characterization of two new acidic Asp49-PLA2s from Bothrops brazili snake venom, named Braziliase-I and Braziliase-II. The venom was fractionated in three chromatographic steps: ion exchange, hydrophobic interaction and reversed phase...
September 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28944701/in-response-to-are-changes-necessary-in-the-medical-management-of-a-patient-with-snakebite-regarding-the-incidence-of-hypersensitivity-reaction-to-antivenom-polyvalent-immune-fab
#11
Justin Rizer, Joshua King, Nathan Charlton
No abstract text is available yet for this article.
September 25, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28915823/patients-with-acute-poisoning-presenting-to-an-urban-emergency-department-of-a-tertiary-hospital-in-tanzania
#12
Ghaniya S Mbarouk, Hendry R Sawe, Juma A Mfinanga, John Stein, Shankar Levin, Victor Mwafongo, Michael S Runyon, Teri A Reynolds, Kent R Olson
BACKGROUND: Poisoning is a major public health concern in sub-Saharan Africa, affecting patients of all age groups. Poisoned patients often present to the emergency department (ED) and prompt evaluation and appropriate management are imperative to ensure optimal outcomes. Unfortunately, little is known about the specific presentations of poisoned patients in East Africa. We describe the clinical and epidemiological features of patients presenting to the Muhimbili National Hospital (MNH) ED with suspected toxicological syndromes...
September 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28913414/diversity-of-aerobic-bacteria-isolated-from-oral-and-cloacal-cavities-from-free-living-snakes-species-in-costa-rica-rainforest
#13
Allan Artavia-León, Ariel Romero-Guerrero, Carolina Sancho-Blanco, Norman Rojas, Rodolfo Umaña-Castro
Costa Rica has a significant number of snakebites per year and bacterial infections are often complications in these animal bites. Hereby, this study aims to identify, characterize, and report the diversity of the bacterial community in the oral and cloacal cavities of venomous and nonvenomous snakes found in wildlife in Costa Rica. The snakes where captured by casual encounter search between August and November of 2014 in the Quebrada González sector, in Braulio Carrillo National Park. A total of 120 swabs, oral and cloacal, were taken from 16 individuals of the Viperidae and Colubridae families...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28905944/snakebite-envenoming
#14
REVIEW
José María Gutiérrez, Juan J Calvete, Abdulrazaq G Habib, Robert A Harrison, David J Williams, David A Warrell
Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects...
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28905943/snakebite-envenoming
#15
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28904556/medicinal-plants-for-the-treatment-of-local-tissue-damage-induced-by-snake-venoms-an-overview-from-traditional-use-to-pharmacological-evidence
#16
REVIEW
Juliana Félix-Silva, Arnóbio Antônio Silva-Junior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28884034/snakebite-induced-thrombotic-microangiopathy-leading-to-renal-cortical-necrosis
#17
Ying Mao Gn, Arvind Ponnusamy, Vikram Thimma
Renal complications from snakebite result in high mortality and morbidity. Acute kidney injury (AKI) occurs in 5-30% of cases. Renal manifestation could include acute tubular necrosis, cortical necrosis, interstitial nephritis, glomerulonephritis, and vasculitis. We present a case of thrombotic microangiopathy (TMA) resulting in renal cortical necrosis. Renal biopsy showed fibrin thrombi in glomeruli and arterioles with cortical necrosis. Our patient progressed to end-stage renal disease.
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28878435/assessment-of-knowledge-about-snakebite-management-amongst-healthcare-providers-in-the-provincial-and-two-district-hospitals-in-savannakhet-province-lao-pdr
#18
Vongphoumy Inthanomchanh, Joshua A Reyer, Joerg Blessmen, Ketkesone Phrasisombath, Eiko Yamamoto, Nobuyuki Hamajima
Snakebite is a neglected condition and a common public health problem in Lao People's Democratic Republic (Lao PDR), with a high incidence of up to 1,105 cases per 100,000 persons per year. Snakebite patients with systemic envenoming do not receive effective treatment at local health facilities. Healthcare providers have only limited knowledge in assessing and providing the correct treatment for venomous snakebites. A cross-sectional study was conducted among 119 healthcare providers in Savannakhet Province, Lao PDR, with respect to their socio-demographic characteristics, knowledge of snake identification, and management of snakebite...
August 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28877511/severe-neurotoxicity-requiring-mechanical-ventilation-in-a-dog-envenomed-by-a-red-bellied-black-snake-pseudechis-porphyriacus-and-successful-treatment-with-an-experimental-bivalent-whole-equine-igg-antivenom
#19
A M Padula, E M Leister
Snakebite in dogs from Pseudechis porphyriacus (red-bellied black snake; RBBS) is a common envenomation treated by veterinarians in Australia where this snake occurs. This case report describes the successful treatment of a clinically severe RBBS envenomation in a dog with an experimental bivalent equine whole IgG antivenom and mechanical ventilation, following its presentation in a cyanotic state. The cause of the cyanosis and respiratory distress was considered due to paralysis from neurotoxins in RBBS venom...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28867663/high-density-peptide-microarray-exploration-of-the-antibody-response-in-a-rabbit-immunized-with-a-neurotoxic-venom-fraction
#20
Mikael Engmark, Martin C Jespersen, Bruno Lomonte, Ole Lund, Andreas H Laustsen
Polyvalent snakebite antivenoms derive their therapeutic success from the ability of their antibodies to neutralize venom toxins across multiple snake species. This ability results from a production process involving immunization of large mammals with a broad suite of toxins present in venoms. As a result of immunization with this wide range of toxins, many polyvalent antivenoms have a high degree of cross-reactivity to similar toxins in other snake venoms - a cross-reactivity which cannot easily be deconvoluted...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
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