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https://www.readbyqxmd.com/read/28548314/scorpionate-complexes-of-aza-18-crown-6-containing-fluoronitrophenyl-substituents-as-studied-by-esi-ms
#1
Rafał Frański, Magdalena Onyszkiewicz, Błażej Gierczyk
RATIONALE: Coordination of a metal cation by a nitro group is rare and the interaction between them is usually weak. Examples of complexes in which such an interaction takes place are metal complexes of cyclams containing nitrophenyl or nitrobenzyl substituents. It seemed to be interesting to check if in the complexes of respective crown ether conjugates the interaction can also take place. METHODS: We synthesized the respective conjugates of aza-18-crown-6, namely fluoro-substituted N-nitrophenylaza-18C6 conjugates...
May 26, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28540206/acute-kidney-injury-from-different-poisonous-substances
#2
Rubina Naqvi
AIM: To report our experience of acute kidney injury (AKI) developed after exposure to poisonous substance. METHODS: Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016. This institution is a tertiary care center for renal care in the metropolitan city of Karachi, Pakistan. History of ingested substance, symptoms on presentation, basic laboratory tests on arrival, mode of treatment and outcome were recorded from all patients and are presented here...
May 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28536661/successful-use-of-extracorporeal-membrane-oxygenation-for-the-treatment-of-cardiogenic-shock-due-to-scorpion-envenomation
#3
Amine Tarmiz, Imene Mgarrech, Chokri Kortas, Sofiane Jerbi
Introduction. The occurrence of a cardiogenic shock is a rare presentation after scorpion envenomation. The treatment includes classically the use of inotropes and specific vasodilators. Case Presentation. We report a case of an 11-year-old boy presenting with cardiogenic shock and pulmonary edema after a scorpion sting. Despite adequate management at the emergency department and intensive care unit, the patient's hemodynamic status worsened rapidly, justifying his transfer to our department for ventricular mechanical assistance by venoarterial extracorporeal membrane oxygenation...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28528674/sodium-channels-and-venom-peptide-pharmacology
#4
Mathilde R Israel, Bryan Tay, Jennifer R Deuis, Irina Vetter
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28528669/modulation-of-ion-channels-by-cysteine-rich-peptides-from-sequence-to-structure
#5
Mehdi Mobli, Eivind A B Undheim, Lachlan D Rash
Venom peptides are natural ligands of ion channels and have been used extensively in pharmacological characterization of various ion channels and receptors. In this chapter, we survey all known venom peptide ion-channel modulators. Our survey reveals that the majority of venom peptides characterized to date target voltage-gated sodium or potassium channels. We further find that the majority of these peptides are found in scorpion and spider venoms. We discuss the influence of the pharmacological tools available in biasing discovery and the classical "toxin-to-sequence" approach to venom peptide biodiscovery...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28527288/-partial-purification-of-peptides-present-in-the-tityus-macrochirus-buthidae-scorpion-venom-and-preliminary-assessment-of-their-cytotoxicity
#6
Clara Andrea Rincón-Cortés, Edgar Antonio Reyes-Montaño, Nohora Angélica Vega-Castro
INTRODUCTION: Scorpion venom contains peptides with neurotoxic action primarily active on ion channels in the nervous system of insects and mammals. They are also characterized as cytolytic and anticancer, biological characteristics that have not yet been reported for the Tityus macrochirus venom. OBJECTIVE: To assess if the total T. macrochirus venom and the fraction of partially purified peptides decrease the viability of various tumor-derived cell lines. MATERIALS AND METHODS: The scorpion venom was collected by electrical stimulation and, subsequently, subjected to chromatography, electrophoresis, and ultrafiltration with Amicon Ultra 0...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28525944/oxidative-stress-and-some-biochemical-alterations-due-to-scorpion-leiurus-quinquestriatus-crude-venom-in-rats
#7
Muhammad M A Salman, Seddik Hammad
Scorpion envenomation is a common medical problem in many countries; it is an important cause of morbidity and mortality. The venom of Leiurus quinquestriatus (LQ) is responsible for a number of deaths in children and adults. It has been stated that specific pathophysiological conditions such as generation of oxygen free radicals may trigger the onset of multiple organ dysfunction; therefore, the present study aimed to assess the oxidative stress mediated by LQ crude venom and its effect on the biochemical parameters in rats...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28516208/safety-and-efficiency-of-active-immunization-with-detoxified-antigen-against-scorpion-venom-side-effect-evaluation
#8
Nassrine Bachsais, Lila Boussag-Abib, Fatima Laraba-Djebari
OBJECTIVE: The efficiency and safety of vaccine are the most important properties, however, as any medication, it can induce side effects. This prophylactic therapy could be used to prevent the lethal and pathophysiological effects induced after scorpion envenomation. METHODS: In this study, detoxified venom associated to alum adjuvant (V*alum) is used as a vaccine against scorpion venom for immunization of mice. We evaluate the safety and the inflammatory response of this vaccine...
May 17, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28502745/pi5-and-pi6-two-undescribed-peptides-from-the-venom-of-the-scorpion-pandinus-imperator-and-their-effects-on-k-channels
#9
T Olamendi-Portugal, A Csoti, J M Jimenez-Vargas, F Gomez-Lagunas, G Panyi, L D Possani
This work reports the isolation, chemical and functional characterization of two previously unknown peptides purified from the venom of the scorpion Pandinus imperator, denominated Pi5 and Pi6. Pi5 is a classical K(+)-channel blocking peptide containing 33 amino acid residues with 4 disulfide bonds. It is the first member of a new subfamily, here defined by the systematic number α-KTx 24.1. Pi6 is a peptide of unknown real function, containing only two disulfide bonds and 28 amino acid residues, but showing sequence similarities to the κ-family of K-channel toxins...
May 11, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28494175/the-effect-of-plasmapheresis-on-treating-disseminated-intravascular-coagulation-dic-caused-by-a-hemiscorpius-lepturus-gadim-sting
#10
Babak Mostafazadeh, Ahmad Gorbani, Mitra Mogaddaspour, Hamid Reza Khoddami Vishteh
INTRODUCTION: The highest mortality from scorpion stings in Iran is due to the stings of a particular type of scorpion known as Hemiscorpius lepturus (H. lepturus, Gadim in local language). The present study aimed at investigating the use of plasmapheresis to treat severe cases of H. lepturus stings. METHOD: This pilot study was a randomized clinical trial conducted from June 2015 to June 2016 in Razi hospital of Ahvaz, Iran. Twenty-nine patients who had been stung by H...
May 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28488065/spect-imaging-and-radionuclide-therapy-of-glioma-using-131-i-labeled-buthus-martensii-karsch-chlorotoxin
#11
Wenli Qiao, Lingzhou Zhao, Shan Wu, Changcun Liu, Lilei Guo, Yan Xing, Jinhua Zhao
Gliomas, the most prevalent type of brain tumor in adults, are associated with high rates of morbidity and mortality. Recent studies on (131)I labeled scorpion toxins suggest they can be developed as tumor-specific agents for glioma diagnosis and treatment. This study investigated the potential of (131)I labeled Buthus martensii Karsch chlorotoxin ((131)I-BmK CT) as a new approach for targeted imaging and therapy of glioma. The results showed that (131)I can be successfully linked to BmK CT with satisfactory radiochemical purity and stability and that (131)I-BmK CT markedly inhibited glioma cell growth in a dose and time dependent manner, with significant accumulation in glioma cells in vitro...
May 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28477410/supported-c-scorpionate-vanadium-iv-complexes-as-reusable-catalysts-for-xylene-oxidation
#12
Jiawei Wang, Luisa Martins, Ana P C Ribeiro, Sónia A C Carabineiro, José L Figueiredo, Armando J L Pombeiro
C-scorpionate vanadium(IV) [VOxCl3-x{κ3-RC(pz)3}] [pz = pyrazol-1-yl; x = 0, R = SO3 (1); x = 1, R = CH2OH (2) or CH2OSO2Me (3)] complexes supported on functionalized carbon nanotubes (CNT) are the first V-scorpionate catalysts used so far for the neat oxidation of o-, m- or p-xylene, with TBHP (70% aqueous solution), to the corresponding toluic acids (main products), tolualdehydes and methylbenzyl alcohols. Remarkably, a p-toluic acid yield of 43% (73% selectivity, TON = 1.34 × 103) was obtained with 2@CNT in a simple microwave-assisted mild oxidation procedure, using a very low catalyst charge (3...
May 6, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28474015/highly-thermally-stable-and-robust-enantiopure-zirconium-nnn-scorpionates-for-the-controlled-ring-opening-polymerization-of-rac-lactide
#13
Antonio Otero, Juan Fernández-Baeza, Andrés Garcés, Luis F Sánchez-Barba, Agustín Lara-Sánchez, Jaime Martínez-Ferrer, María P Carrión, Ana M Rodríguez
A series of enantiopure alkoxide and thioalkoxide zirconium derivatives [Zr(ER)3(κ(3)-R,R-fbpza)] (1-6) (E = O, R = CHMe21, CHMeEt 2, CH2SiMe33, 2,6-C6H3Me24, 4-(t)BuPh 5; E = S, R = 4-(t)BuPh 6) has been prepared for use as thermally stable and robust initiators in the ROP of rac-lactide. The compounds were prepared by alcoholysis or thioalcoholysis of the tris(amide) precursor [Zr(NMe2)3(κ(3)-R,R-fbpza)] [R,R-fbpzaH = N-p-fluorophenyl-(1R)-1-[(1R)-6,6-dimethylbicyclo[3.1.1]-2-hepten-2-yl]-2,2-bis(3,5-dimethylpyrazol-1-yl)ethylamine] with ROH and ArEH (E = O, S) in a 1 : 3 molar ratio...
May 5, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28459137/lysine-to-arginine-mutagenesis-of-chlorotoxin-enhances-its-cellular-uptake
#14
Paola G Ojeda, Sónia Troeira Henriques, Yijun Pan, Joseph A Nicolazzo, David J Craik, Conan K Wang
Chlorotoxin (CTX), a disulfide-rich peptide from the scorpion Leiurus quinquestriatus, has several promising biopharmaceutical properties, including preferential affinity for certain cancer cells, high serum stability, and cell penetration. These properties underpin its potential for use as a drug design scaffold, especially for the treatment of cancer; indeed, several analogues of CTX have reached clinical trials. Here, we focus on its ability to internalize into cells - a trait associated with a privileged sub-class of peptides called cell-penetrating peptides - and whether it can be improved through conservative substitutions...
April 29, 2017: Biopolymers
https://www.readbyqxmd.com/read/28457601/a-new-species-of-diplocentrus-scorpiones-diplocentridae-with-punctate-pedipalp-surfaces-a-diagnostic-character-within-the-mexicanus-group
#15
Carlos E Santibáñez-López, Edmundo González-Santillán
Diplocentrus duende n. sp. is described based on adult males collected from a locality in the Tehuacán-Cuicatlán Valley, Mexico. This species has punctate pedipalp surfaces, a condition present only in four other species of this specious genus. As suggested here, this condition has evolved independently in these species within the "mexicanus" group of Diplocentrus from the rest of the diplocentrids.
April 27, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28455977/detection-of-braf-nras-kit-gnaq-gna11-and-map2k1-2-mutations-in-russian-melanoma-patients-using-lna-pcr-clamp-and-biochip-analysis
#16
Marina Emelyanova, Lilit Ghukasyan, Ivan Abramov, Oxana Ryabaya, Evgenia Stepanova, Anna Kudryavtseva, Asiya Sadritdinova, Cholpon Dzhumakova, Tatiana Belysheva, Sergey Surzhikov, Lyudmila Lyubchenko, Alexander Zasedatelev, Tatiana Nasedkina
Target inhibitors are used for melanoma treatment, and their effectiveness depends on the tumor genotype. We developed a diagnostic biochip for the detection of 39 clinically relevant somatic mutations in the BRAF, NRAS, KIT, GNAQ, GNA11, MAP2K1 and MAP2K2 genes.We used multiplex locked nucleic acid (LNA) PCR clamp for the preferable amplification of mutated over wild type DNA. The amplified fragments were labeled via the incorporation of fluorescently labeled dUTP during PCR and were hybridized with specific oligonucleotides immobilized on a biochip...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28438053/scorpion-venom-causes-upregulation-of-p53-and-downregulation-of-bcl-xl-and-bid-protein-expression-by-modulating-signaling-proteins-erk-1-2-and-stat3-and-dna-damage-in-breast-and-colorectal-cancer-cell-lines
#17
Abdulrahman Khazim Al-Asmari, Anvarbatcha Riyasdeen, Mozaffarul Islam
Scorpion venoms efficiently block the normal neurotransmitter signaling pathway by prejudicing the ion channel operating mechanism in the body system. Besides its negative effect, venoms also possess some beneficial qualities for humans. They have also been shown to exhibit anticancer properties in various cancer types. This unique property of the venom as an anticancer agent is mainly a result of its role in initiating apoptosis and inhibiting several signaling cascade mechanisms that promote cancer cell proliferation and growth...
April 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28425546/variable-coordination-of-tris-2-pyridyl-phosphine-and-its-oxide-toward-m-hfac-2-a-metal-specifiable-switching-between-the-formation-of-mono-and-bis-scorpionate-complexes
#18
Alexander V Artem'ev, Alexey V Kashevskii, Artem S Bogomyakov, Alexander Yu Safronov, Anastasiya O Sutyrina, Anton A Telezhkin, Irina V Sterkhova
An unexpected substitution of the anionic chelating ligands at the M(II) centre by a neutral tripodal ligand has been observed in the reaction of Mn(II), Co(II), Ni(II) and Cu(II) hexafluoroacetylacetonates (hfac) with tris(2-pyridyl)phosphine (Py3P) or its oxide (Py3P = O). The nature of the metal ion in M(hfac)2 and the M/L ratio determine the degree of substitution of hfac-anions (partial vs. total) and therefore, the structure of the complex formed (scorpionate vs. bis-scorpionate ones, respectively). Hence, the reaction of the ligands with [Cu(hfac)2(H2O)2] in an equimolar ratio affords scorpionate [Cu(N,N',N''-Py3P = X)(O,O'-hfac)(O-hfac)], wherein one hfac-ligand chelates metal, while the other hfac acts as an O-monodentate one...
May 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28416444/the-pharmacology-of-voltage-gated-sodium-channel-activators
#19
REVIEW
Jennifer R Deuis, Alexander Mueller, Mathilde R Israel, Irina Vetter
Toxins and venom components that target voltage-gated sodium (NaV) channels have evolved numerous times due to the importance of this class of ion channels in the normal physiological function of peripheral and central neurons as well as cardiac and skeletal muscle. NaV channel activators in particular have been isolated from the venom of spiders, wasps, snakes, scorpions, cone snails and sea anemone and are also produced by plants, bacteria and algae. These compounds have provided key insight into the molecular structure, function and pathophysiological roles of NaV channels and are important tools due to their at times exquisite subtype-selectivity...
April 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28415833/molecular-characterization-and-biodiversity-of-a-putative-chlorotoxin-from-the-iranian-yellow-scorpion-odontobuthus-doriae
#20
Maryam Naderi Soorki, Amir Jalali, Hamid Galehdari
BAckground: Chloride channels have already been over-expressed in the different types of cancer. Chlorotoxins, as the blocking agent of these channels, have been indicated to be an effective drug against tumors. In this study, we characterized a putative chlorotoxin from a cDNA library of the venom glands obtained from the Iranian scorpion Odontobuthus doriae. Methods: A cDNA library was constructed from venom gland transcriptome of six scorpions. The cDNA encoding Odontobuthus doriae chlorotoxin was isolated from the library, and its putative peptide was characterized by some bioinformatics software such as protein blast, SignalP4...
April 18, 2017: Iranian Biomedical Journal
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