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https://www.readbyqxmd.com/read/28735770/to4-the-first-tityus-obscurus-%C3%AE-toxin-fully-electrophysiologically-characterized-on-human-sodium-channel-isoforms
#1
Harry Morales Duque, Caroline Barbosa Farias Mourão, Diogo Vieira Tibery, Eder Alves Barbosa, Leandro Ambrósio Campos, Elisabeth Ferroni Schwartz
Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilian Amazon, have been partially characterized in previous studies; however, little information about their electrophysiological role on sodium ion channels has been published. In the present study, we describe the purification, identification and electrophysiological characterization of a NaScTx, which was first described as Tc54 and further fully sequenced and renamed To4...
July 20, 2017: Peptides
https://www.readbyqxmd.com/read/28718263/multi-organ-dysfunction-secondary-to-yellow-scorpion-sting
#2
Muhammad Faisal Khan, Hameed Ullah
Scorpion stings are common in tropical and subtropical regions. The history and clinical manifestation warrant urgent recognition and treatment. The incidence of scorpion stings in Pakistan is not known as there is no published data available in literature. We report our experience of a yellow scorpion sting victim who required intensive care admission after developing multi-organ dysfunction.
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712915/comparative-analyses-and-implications-for-antivenom-serotherapy-of-four-moroccan-scorpion-buthus-occitanus-venoms-subspecies-tunetanus-paris-malhommei-and-mardochei
#3
Bruna Luiza Emerich, Maria Elena De Lima, Marie-France Martin-Eauclaire, Pierre E Bougis
Temporary passive immunity such as serotherapy against venoms requires the full knowledge of all venom's components. Here, four venoms from Moroccan common yellow scorpions belonging to Buthus occitanus, subspecies tunetanus, paris, malhommei, and mardochei, all collected in four different restricted areas, were analysed in deep. They were fractionated by reversed-phase high-performance liquid chromatography (RP-HPLC) and their molecular masse profile determined by off-line MALDI-TOF mass spectrometry. Characterisation of their main components was achieved by enzyme-linked immunosorbent assay (ELISA) using specific antisera against the major lethal scorpion toxins identified so far, i...
July 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28700068/implication-of-tityus-apiacas-lourenco-2002-in-scorpion-envenomations-in-the-southern-amazon-border-brazil
#4
Bruna Andressa Jung da Silva, Nelson Ferreira Fé, André Alexandre Dos Santos Gomes, Anderson da Silva Souza, Jacqueline de Almeida Gonçalves Sachett, Hui Wen Fan, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro
Herein, four cases of scorpion stings caused by Tityus apiacas recorded from the municipality of Apuí, in the southern region of the Brazilian Amazon, are described. Patients showed systemic clinical manifestations, described as unusual, involuntary, and generalized tingling and numbness, reported by patients as an electric shock sensation, lasting up to 24 hours after the sting. All patients described local pain and sensation, along with other clinical symptoms including local edema and erythema. Systemic manifestations were not life threatening...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28699006/adsorption-and-mineralization-of-ree-lanthanum-onto-bacterial-cell-surface
#5
Yangjian Cheng, Li Zhang, Xiaojing Bian, Hongyang Zuo, Hailiang Dong
A large number of rare earth element mining and application resulted in a series of problems of soil and water pollution. Environmental remediation of these REE-contaminated sites has become a top priority. This paper explores the use of Bacillus licheniformis to adsorb lanthanum and subsequent mineralization process in contaminated water. The maximum adsorption capacity of lanthanum on bacteria was 113.98 mg/g (dry weight) biomass. X-ray diffraction (XRD) and transmission electron microscopy (TEM) data indicated that adsorbed lanthanum on bacterial cell surface occurred in an amorphous form at the initial stage...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28695745/treating-autoimmune-disorders-with-venom-derived-peptides
#6
Bingzheng Shen, Zhijian Cao, Wenxin Li, Jean-Marc Sabatier, Yingliang Wu
The effective treatment of autoimmune diseases remains a challenge. Voltage-gated potassium Kv1.3 channels, which are expressed in lymphocytes, are a new therapeutic target for treating autoimmune disease. Consequently, Kv1.3 channel-inhibiting venom-derived peptides are a prospective resource for new drug discovery and clinical application. Area covered: Preclinical and clinical studies have produced a wealth of information on Kv1.3 channel-inhibiting venom-derived peptides, especially from venomous scorpions and sea anemones...
July 11, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28689960/scorpion-stings-in-jordan-an-update
#7
Zuhair S Amr, Renad Al Zou'bi, Nour Abdo, Rihan Bani Hani
OBJECTIVE: Scorpionism is an endemic public health problem in Jordan encountered by health providers in all parts of the country. This study updates epidemiological data on scorpion sting encounters in Jordan. METHODS: Data on scorpion sting encounters were obtained from government and military hospitals around the country, and the National Drug and Poison Information Center (NDPIC). P values and 95% confidence intervals (CIs) were calculated using SPSS Professional Statistics Package version 22 (IBM Corp...
July 6, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28689025/venom-derived-peptide-inhibitors-of-voltage-gated-potassium-channels
#8
REVIEW
Raymond S Norton, K George Chandy
Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade...
July 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28669947/-larvicidal-activity-of-recombinant-escherichia-coli-expressing-scorpion-neurotoxin-aait-or-b-t-i-toxin-cyt2ba-against-mosquito-larvae-and-formulations-for-enhancing-the-effects
#9
Sheng-Qun Deng, Ming-Zhi Deng, Jia-Ting Chen, Li-Lan Zheng, Hong-Juan Peng
OBJECTIVE: To assess the larvicidal effects of recombinant Escherichia coli expressing scorpion neurotoxin AaIT or Bacillus thuringiensis subsp israelensis (B.t.i) toxin Cyt2Ba against the second instar larvae of Culex pipiensquinquefasciatus and Aedes albopictus and compare different formulations for their larvicidal effects. METHODS: The AaIT- or Cyt2Ba-coding sequences were cloned into pET28a(+) and the recombinant plasmids were transformed into E. coli BL21(DE3)...
June 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28668647/toxicological-evaluation-of-the-aqueous-whole-plant-extract-of-aerva-lanata-l-juss-ex-schult-amaranthaceae
#10
Kayode S Omotoso, Flora R Aigbe, Olanrewaju A Salako, Micah C Chijioke, Oluwafunmilayo O Adeyemi
ETHNOPHARMACOLOGICAL RELEVANCE: Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported. There is, however, no scientific report on its toxicity profile to the best of our knowledge. AIM OF THE STUDY: This study was therefore aimed at investigating the toxicity profile of the aqueous extract of Aerva lanata...
June 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28668484/a-new-genus-and-species-of-scorpion-from-burma-myanmar-scorpiones-scorpiopidae-implications-for-the-taxonomy-of-the-family
#11
Wilson R Lourenço
Plethoscorpiops profusus gen. n., sp. n., belonging to the family Scorpiopidae Kraepelin, 1905 is described on the basis of two specimens, one adult female and one male juvenile collected in the Saddan Cave, in Kayin State, Hpa-An, Burma (Myanmar). This new scorpion taxon most certainly represents an endemic element for the fauna of Burma and seems to be strictly distributed inside the cave system. The new genus is characterized by a previously unknown and totally unique plethotaxic trichobothrial pattern within the family Scorpiopidae...
June 28, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28657596/antibacterial-activity-and-toxicity-of-analogs-of-scorpion-venom-isct-peptides
#12
Roberto de la Salud Bea, Adam F Petraglia, Michael R Ascuitto, Quentin M Buck
Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2-found in the venom of scorpion Opithancatus Madagascariensis-have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with alanine, valine, and leucine, enhances antibacterial activity. However, this also increases hemolytic activity. The analog with an increased net positive charge from +1 to +3 produces moderate bacterial growth inhibition but also has high hemolytic activity...
June 28, 2017: Antibiotics
https://www.readbyqxmd.com/read/28655685/severe-scorpion-envenomation-pathophysiology-and-the-role-of-inflammation-in-multiple-organ-failure
#13
M Bahloul, K Regaieg, I Chabchoub, M Kammoun, K Chtara, M Bouaziz
Scorpion stings occur on every continent except Antarctica. The correlation between young age and severity of clinical manifestations after this envenomation is well-established. Several studies have emphasized the relevance of pro-inflammatory mediators in the pathophysiological manifestations of human scorpion envenomation. Moreover, there is a significant association between pro-inflammatory cytokine levels in the blood and the severity of scorpion envenomation. Release of these cytokines increases the severity of the visceral damage induced by the direct action of the venom and the activation of both the sympathetic and parasympathetic nervous systems...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28655185/local-knockdown-of-nav1-6-relieves-pain-behaviors-induced-by-bmk-i
#14
Shichao Qin, Feng Jiang, You Zhou, Guokun Zhou, Pin Ye, Yonghua Ji
Voltage-gated sodium channels (VGSCs) in peripheral nociceptive sensory neurons are critical to transmit pain signals. BmK I purified from the venom of scorpion Buthus martensi Karsch (BmK) has been demonstrated to be the primary contributor of envenomation-associated pain. However, the role of distinct VGSCs such as Nav1.6 in the induction and maintenance of pain behaviors induced by BmK I was ambiguous. Herein, using molecular and behavioral approaches we investigated the mRNA and protein expression profiles of Nav1...
June 24, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28647179/euphorbia-neriifolia-l-review-on-botany-ethnomedicinal-uses-phytochemistry-and-biological-activities
#15
REVIEW
Prashant Y Mali, Shital S Panchal
The present review is intended to provide information on botany, ethnomedicinal uses, phytochemistry and biological activities of various parts of Euphorbia neriifolia (E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative, purgative, rubefacient, carminative and expectorant as well as in treatment of whooping cough, gonorrhoea, leprosy, asthma, dyspepsia, jaundice, enlargement of the spleen, tumours, stone in the bladder, abdominal troubles and leucoderma...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28634472/antifungal-activity-against-filamentous-fungi-of-ts1-a-multifunctional-toxin-from-tityus-serrulatus-scorpion-venom
#16
Welligton M Santussi, Karla C F Bordon, Ana P N Rodrigues Alves, Camila T Cologna, Suraia Said, Eliane C Arantes
Antimicrobial peptides (AMPs) are ubiquitous and multipotent components of the innate immune defense arsenal used by both prokaryotic and eukaryotic organisms. The search for new AMPs has increased in recent years, due to the growing development of microbial resistance to therapeutical drugs. In this work, we evaluate the effects of Tityus serrulatus venom (Tsv), its fractions and its major toxin Ts1, a beta-neurotoxin, on fungi growth. The fractions were obtained by ion-exchange chromatography of Tsv. The growth inhibition of 11 pathogenic and non-pathogenic filamentous fungi (Aspergillus fumigatus, A...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28631790/multidentate-silyl-ligands-in-transition-metal-chemistry
#17
M Simon, F Breher
Silyl ligands are of great interest in transition metal coordination chemistry since they exhibit a strong trans-influence and create electron rich metals centres, which are in turn eligible to activate reagents. This review presents and discusses the use of multidentate Si-based ligand systems in transition metal coordination chemistry. These include tri- and tetradentate pincer and scorpionate-type ligands, which have been developed in recent years in order to tailor both steric and electronic properties for achieving a defined control over the reactivity of a transition metal complex...
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28630618/perinatal-effects-of-scorpion-venoms-maternal-and-offspring-development
#18
REVIEW
Ana Leticia Coronado Dorce, Adriana do Nascimento Martins, Valquiria Abrão Coronado Dorce, Ana Leonor Abrahão Nencioni
Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possible victims. Scorpion stings alter the release of neurotransmitters and some cytokines. These mediators act as organizers and programmers in the adequate formation of the nerves, and non-physiological concentrations of them during the brain organization originate disorders and diseases that can appear later in the life of the individual...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28617636/a-sea-scorpion-s-strike-new-evidence-of-extreme-lateral-flexibility-in-the-opisthosoma-of-eurypterids
#19
W Scott Persons, John Acorn
Among the largest and most abundant aquatic predators during much of the early evolution of vertebrates, eurypterids have long been an iconic and intensely studied group of Paleozoic arthropods. We report a new specimen of the eurypterid Slimonia acuminata, which includes a fully articulated series of tail (postabdominal and telsonal) segments preserved in a tight lateral curve. Such a high degree of apparent lateral tail flexibility has not been previously recognized in eurypterids. From the perspective of hydrodynamics, the dorsoventrally flattened body plan of eurypterids would have limited the effectiveness of lateral tail motion as a means of propulsion...
July 2017: American Naturalist
https://www.readbyqxmd.com/read/28610102/a-new-species-in-the-troglomorphic-scorpion-genus-i-troglotayosicus-i-from%C3%A2-colombia-representing-the-northernmost-known-record-for-the-genus%C3%A2-scorpiones-troglotayosicidae
#20
Ricardo Botero-Trujillo, Julio C González-Gómez, Juan C Valenzuela-Rojas, Luis F García
We describe a new scorpion species in the troglomorphic genus Troglotayosicus Lourenço, 1981 from Colombia. Troglotayosicus meijdeni sp. nov. inhabits the forest leaf litter at Rivera municipality, on the western slope of the Eastern Andes. The male of the new species remains unknown; however, this species can be distinguished from other species in the genus by the female (and juvenile) morphology. The type locality of T. meijdeni sp. nov. represents the northernmost known record for a population of Troglotayosicus, further extending the known limits of distribution of this genus, and shedding more light on the distributional range of this group of scorpions in northwestern South America...
March 22, 2017: Zootaxa
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