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https://www.readbyqxmd.com/read/28813592/3d-printed-phema-materials-for-topographical-and-biochemical-modulation-of-dorsal-root-ganglion-cell-response
#1
Adina Badea, Joselle M McCracken, Emily G Tillmaand, Mikhail Eugene Kandel, Aaron W Oraham, Molly B Mevis, Stanislav S Rubakhin, Gabriel Popescu, Jonathan V Sweedler, Ralph G Nuzzo
Understanding and controlling the interactions occurring between cells and engineered materials are central challenges towards progress in the development of biomedical devices. In this work, we describe materials for direct ink writing (DIW), an extrusion-based type of 3D printing, that embed a custom synthetic protein (RGD-PDL) within the microfilaments of 3D-hydrogel scaffolds to modify these interactions and differentially direct tissue-level organization of complex cell populations in vitro. The RGD-PDL is synthesized by modifying poly-ᴅ-lysine (PDL) to varying extents with peptides containing the integrin-binding motif Arg-Gly-Asp (RGD)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812933/use-of-bilayer-matrix-wound-dressing-in-the-exenterated-socket
#2
Leon Rafailov, Roger E Turbin, Paul D Langer
To describe the novel use of a bilayer dermal substitute to reconstruct exenterated orbits. A retrospective chart review was performed in the practices of two surgeons (RET and PDL) of all patients who had undergone orbital exenteration between April 2014 and June 2016 and whose subsequent reconstruction included lining the socket with Integra bilayer. Patient demographics, pathologic diagnoses, surgical and post-operative complications, graft integrity, and patient acceptance were recorded. The charts of 7 patients (4 men and 3 women, ages 60-87 years) were reviewed...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812167/superficial-hemangioma-is-better-treated-by-topical-5-aminolevulinic-followed-by-595-nm-pulsed-dye-laser-therapy-rather-than-595-nm-laser-therapy-alone
#3
Ming Zeng, Songke Shen, Wei Chen, Chunjun Yang, ShengXiu Liu
The aim of this study was to compare the efficacy and adverse effects of a 595-nm pulsed dye laser therapy alone (PDL alone) with a 5-aminolevulinic (5-ALA) local application followed by a 595-nm PDL (5-ALA PDL) in the treatment of superficial hemangioma (SH). A prospectively randomized study in 181 patients with SH was carried out over a period of 24 months. One hundred and ninety-three patients were seen. One hundred and eighty-one patients with SH were enrolled, of which 165 completed final follow-up. One hundred and nineteen patients received PDL alone and 46 received 5-ALA PDL...
August 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28776112/laser-treatments-of-active-acne
#4
REVIEW
Lauren E Wiznia, Mary L Stevenson, Arielle R Nagler
The utility of laser therapy is increasingly being recognized in the treatment of active acne vulgaris. We aimed to perform a narrative review of the medical literature on the use of laser therapy for the treatment of active acne vulgaris. We performed a PubMed literature search on September 1, 2016 using the search terms "active acne," "acne," "laser therapy," and "laser surgery." Case reports, case series, cohort, and controlled trials were included. Studies of lasers in the treatment of acne, including erbium glass, Nd:YAG, pulse dye laser (PDL), potassium titanyl phosphate (KTP) laser, and laser-based photodynamic therapy, have been published...
August 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28775125/smad3-stat3-signaling-mediates-%C3%AE-cell-epithelial-mesenchymal-transition-in-chronic-pancreatitis-related-diabetes
#5
Xiangwei Xiao, Shane Fischbach, Tina Zhang, Congde Chen, Qingfeng Sheng, Ray Zimmerman, Sneha Patnaik, Joseph Fusco, Yungching Ming, Ping Guo, Chiyo Shiota, Krishna Prasadan, Nupur Gangopadhyay, Sohail Z Husain, Henry Dong, George K Gittes
Many patients with chronic pancreatitis develop diabetes (chronic pancreatitis-related diabetes; CPRD) through an undetermined mechanism. Here, we used long-term partial pancreatic duct ligation (PDL) as a model to study CPRD. We found that long-term PDL induced significant β-cell dedifferentiation, followed by a time-dependent decrease in functional β-cell mass, all specifically in the ligated tail portion of the pancreas (PDL-tail). High levels of transforming growth factor β1 (TGFβ1) were detected in the PDL-tail, mainly produced by M2 macrophages at the early stage, and by activated myofibroblasts at the later stage...
August 3, 2017: Diabetes
https://www.readbyqxmd.com/read/28764282/nature-s-benefaction-as-a-life-saver-for-an-avulsed-tooth-an-in-vitro-study
#6
Saumya Navit, Niharika Shahi, Suleman Abbas Khan, Anshul Sharma, Vartika Singh, Ratna Priya Mishra, Pragati Navit, Prerna Sharma
INTRODUCTION: Dentoalveolar trauma is a very common and avulsion is the most frequent injury. Treatment of choice following avulsion is immediate reimplantation. However, in cases where this might not be possible the prognosis of reimplanted teeth can be improved by the selection of an appropriate storage media. Prevention of ankylosis and replacement resorption depends more on the potential of storage media to maintain cell viability rather than the extraalveolar time period. AIM: To compare and evaluate the efficacy of different storage media in maintaining the viability of Periodontal Ligament (PDL) cells in an avulsed tooth...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763754/effects-of-prostaglandin-e2-on-clonogenicity-proliferation-and-expression-of-pluripotent-markers-in-human-periodontal-ligament-cells
#7
Avirut Truntipakorn, Anupong Makeudom, Thanapat Sastraruji, Prasit Pavasant, Kassara Pattamapun, Suttichai Krisanaprakornkit
BACKGROUND AND OBJECTIVE: Based on our earlier work on the response of periodontal ligament (PDL) cells to mechanical stress by induction of cyclooxygenase expression and production of prostaglandin PGE2 that could regulate mineralization of PDL cells, it was hypothesized that PGE2 had potential effects on PDL stemness. In this study, we aimed to investigate clonogenicity, proliferation and expression of certain pluripotent markers, considered to be characteristics of PDL stemness, in response to treatment with exogenously-added PGE2...
July 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28759110/effects-of-early-combinatorial-treatment-of-autologous-split-thickness-skin-grafts-in-red-duroc-pig-model-using-pulsed-dye-laser-and-fractional-co2-laser
#8
J Kevin Bailey, Britani N Blackstone, Danielle M DeBruler, Jayne Y Kim, Molly E Baumann, Kevin L McFarland, Folasade O Imeokparia, Dorothy M Supp, Heather M Powell
BACKGROUND AND OBJECTIVE: The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studies report positive outcomes following PDL or FX CO2 therapy, a number of studies have reported no benefit or worsening of the scar following treatment. The objective of this study was to directly compare the efficacy of PDL, FX CO2 , and PDL + FX CO2 laser therapy in reducing scarring post burn injury and autografting in a standardized animal model...
July 31, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28758247/pulsed-dye-laser-treatment-of-port-wine-stains-in-children-useful-tips-to-avoid-general-anesthesia
#9
Adrián Alegre-Sánchez, Bibiana Pérez-García, Pablo Boixeda
Pulsed dye laser (PDL) treatment of port-wine stains (PWSs) in children is a common procedure performed in most laser units. Pain assessment in our younger patients is a major concern, especially in those with extensive PWSs. The use of general anesthesia (GA) results in pain-free treatment, but its effects on the developing brain are far from totally understood. Thus we propose some tips that avoid the use of GA in most of our young patients, including the use of topical anesthetics and cooling systems, large laser spot size and high frequencies, early and frequent treatment with parents present, and the "introduction" and "pressure" techniques, among others...
July 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28752575/ipl-vs-pdl-in-treatment-of-facial-erythema-a-split-face-study
#10
Marc Z Handler, Bradley S Bloom, David J Goldberg
BACKGROUND: Lasers and noncoherent intense pulse light sources effectively treat vascular lesions. Intense pulsed light (IPL), a nonablative treatment for photorejuvenation, uses a flashlamp which emits noncoherent light between 400 and 1400 nm. The light may be filtered to target a specific chromophore. The pulsed dye laser (PDL), at 595 nm, has been the historical standard of care in the treatment of facial erythema. We sought to determine whether IPL may be used in lieu of PDL in reducing facial erythema...
July 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28750153/safety-and-efficacy-of-dual-wavelength-laser-1064-nm-595-nm-for-treatment-of-non-treated-port-wine-stains
#11
Tianyou Wang, Da Chen, Jingyan Yang, Gang Ma, Wenxin Yu, Xiaoxi Lin
BACKGROUND: Patients with port-wine stain (PWS) suffer physically and psychologically because of the high incidence (0.3%-0.5%) of the disease. Pulsed dye laser (PDL) at 595 nm is the gold standard of the treatment for PWS. Nevertheless, clinicians intend to determine whether the dual wavelength laser (DWL) (595 nm PDL + 1064 nm Nd:YAG) is an adequate choice in the treatment of non-treated PWS. This study is the first prospective within-patient controlled research seeking to investigate the safety and efficacy of DWL for the treatment of non-treated PWS...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28743370/computational-and-clinical-investigation-on-the-role-of-mechanical-vibration-on-orthodontic-tooth-movement
#12
Zhipeng Liao, Selma Elekdag-Turk, Tamer Turk, Johnathan Grove, Oyku Dalci, Junning Chen, Keke Zheng, M Ali Darendeliler, Michael Swain, Qing Li
The aim of this study is to investigate the biomechanics for orthodontic tooth movement (OTM) subjected to concurrent single-tooth vibration (50Hz) with conventional orthodontic force application, via a clinical study and computational simulation. Thirteen patients were recruited in the clinical study, which involved distal retraction of maxillary canines with 1.5N (150g) force for 12weeks. In a split mouth study, vibration and non-vibration sides were randomly assigned to each subject. Vibration of 50Hz, of approximately 0...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28720089/analysis-of-the-association-between-millennium-development-goals-4-5-and-the-physician-workforce-across-international-economic-strata
#13
Christopher P Morley, Dongliang Wang, Emily M Mader, Kyle P Plante, Lindsey N Kingston, Azadeh Rabiei
BACKGROUND: The Millennium Development Goals (MDGs) are 8 international development goals voluntarily adopted by 189 nations. The goals included health related aims to reduce the under-five child mortality rate by two-thirds (MDG4), and to reduce the maternal mortality ratio by three-quarters (MDG5). To assess the relationship between the healthcare workforce and MDGs 4-5, we examined the physician workforces of countries around the globe, in terms of the Physician Density Level (PDL, or number of physicians per 1000 population), and compared this rate across a number of years to several indicator variables specified as markers of progress towards MDG4 and MDG5...
July 18, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28715096/effect-of-avulsion-storage-media-on-periodontal-ligament-fibroblast-differentiation
#14
İrem Bağ, Sibel Yildirim
BACKGROUND/AIM: An avulsed tooth must be stored in a solution which maintains periodontal ligament (PDL) cell viability. The aim of this study was to compare the effects of Hank's Balanced Salt Solution (HBSS) and milk on the differentiation of PDL fibroblasts. MATERIAL AND METHODS: Eighteen extracted third molars, (n = 3 for each group), were immersed in HBSS, milk, and Dulbecco's Modified Eagle Medium-Ham's F12 (DMEM-F12) at 4 °C for 30-60 min or 12 h. The growth dynamics of PDL fibroblasts were evaluated with cell proliferation graphics and population doubling time (PDT) values...
July 17, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28713908/comparison-of-gene-expression-profiles-between-dental-pulp-and-periodontal-ligament-tissues-in-humans
#15
Ai-Xiu Gong, Jing-Han Zhang, Jing Li, Jun Wu, Lin Wang, Deng-Shun Miao
There are anatomical and functional differences between human dental pulp (DP) and periodontal ligament (PDL). However, the molecular biological differences and function of these tissues are poorly understood. In the present study, we employed a cDNA microarray array to screen for differentially expressed genes (DEGs) between human DP and PDL tissues, and used the online software WebGestalt to perform the functional analysis of the DEGs. In addition, the STRING database and KEGG pathway analysis were applied for interaction network and pathway analysis of the DEGs...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28708037/greater-sensitivity-of-oral-fibroblasts-to-smoked-vs-smokeless-tobacco
#16
Thomas E Lallier, John T Moylan, Erin Maturin
OBJECTIVE: Smokers have an increased incidence and severity of periodontal disease. While cigarette smoke contains over 4,000 chemical components that could affect periodontal tissues, less is understood about the effect of smokeless tobacco. Therefore, this study compared the effects of cigarette smoke extract (CSE) to smokeless tobacco extract (STE) on cell survival and motility of periodontal ligament (PDL) and gingival fibroblasts in vitro. METHODS: PDL and gingival fibroblasts were exposed to varying concentrations of CSE, STE or nicotine alone...
July 14, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28691752/mineral-trioxide-aggregate-improves-healing-response-of-periodontal-tissue-to-injury-in-mice
#17
I Vidovic Zdrilic, I O de Azevedo Queiroz, B G Matthews, J E Gomes-Filho, M Mina, I Kalajzic
BACKGROUND AND OBJECTIVE: Mineral trioxide aggregate (MTA) is a biomaterial used in endodontic procedures as it exerts beneficial effects on regenerative processes. In this study, we evaluate the effect of MTA on healing of periodontal ligament (PDL) and surrounding tissue, following injury, in a transgenic mouse model and on the differentiation of murine mesenchymal progenitor cells in vitro. MATERIAL AND METHODS: We used an inducible Cre-loxP in vivo fate mapping approach to examine the effects of MTA on the contributions of descendants of cells expressing the αSMA-CreERT2 transgene (SMA9(+) ) to the PDL and alveolar bone after experimental injury to the root furcation on the maxillary first molars...
July 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28689797/pudilan-xiaoyan-oral-liquid-alleviates-lps-induced-respiratory-injury-through-decreasing-nitroxidative-stress-and-blocking-tlr4-activation-along-with-nf-%C3%AE-b-phosphorylation-in-mice
#18
Liang Feng, Nan Yang, Chao Li, Gang Tian, Jing Wang, Zi-Bo Dong, Xiao-Bin Jia, Liu-Qing Di
ETHNOPHARMACOLOGICAL RELEVANCE: Pudilan xiaoyan oral liquid (PDL), collected in Chinese Pharmacopoeia, has been used clinically for treating inflammatory diseases such as upper respiratory tract infection diseases. However, its potential anti-inflammation and the mechanism are still unclear. MATERIALS AND METHODS: lipopolysaccharide (LPS) was used to induce respiratory inflammation of mice by intratracheal administration. UPLC/MS was performed for components analysis of PDL...
July 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28681925/wnt5a-suppresses-osteoblastic-differentiation-of-human-periodontal-ligament-stem-cell-like-cells-via-ror2-jnk-signaling
#19
Daigaku Hasegawa, Naohisa Wada, Shinichiro Yoshida, Hiromi Mitarai, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Hideki Sugii, Hidefumi Maeda
Wnt5a, a non-canonical Wnt protein, is known to play important roles in several cell functions. However, little is known about the effects of Wnt5a on osteoblastic differentiation of periodontal ligament (PDL) cells. Here, we examined the effects of Wnt5a on osteoblastic differentiation and associated intracellular signaling in human PDL stem/progenitor cells (HPDLSCs). We found that Wnt5a suppressed expression of bone-related genes (ALP, BSP, and Osterix) and alizarin red-positive mineralized nodule formation in HPDLSCs under osteogenic conditions...
July 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28681629/cyclic-stretch-induced-the-cytoskeleton-rearrangement-and-gene-expression-of-cytoskeletal-regulators-in-human-periodontal-ligament-cells
#20
Yaqin Wu, Jiabao Zhuang, Dan Zhao, Fuqiang Zhang, Jiayin Ma, Chun Xu
OBJECTIVE: This study aimed to explore the mechanism of the stretch-induced cell realignment and cytoskeletal rearrangement by identifying several mechanoresponsive genes related to cytoskeletal regulators in human PDL cells. MATERIAL AND METHODS: After the cells were stretched by 1, 10 and 20% strains for 0.5, 1, 2, 4, 6, 12 or 24 h, the changes of the morphology and content of microfilaments were recorded and calculated. Meanwhile, the expression of 84 key genes encoding cytoskeletal regulators after 6 and 24 h stretches with 20% strain was detected by using real-time PCR array...
July 6, 2017: Acta Odontologica Scandinavica
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