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https://www.readbyqxmd.com/read/29759661/integrity-of-the-urethral-sphincter-complex-nerve-sparing-and-long-term-continence-status-after-robotic-assisted-radical-prostatectomy
#1
Myong Kim, Myungchan Park, Sahyun Pak, Seung-Kwon Choi, Myungsun Shim, Cheryn Song, Hanjong Ahn
BACKGROUND: The applicability of the sphincter complex integral theory to robotic-assisted radical prostatectomy (RARP) is unclear, with little known about the long-term effect of sphincter complex integrity on continence. OBJECTIVE: To determine whether the preoperative anatomical and functional features of the sphincter complex and the degree of nerve-sparing affect long-term continence after RARP. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 529 patients who underwent RARP at a single tertiary center...
May 11, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29758960/biomechanical-investigation-of-orthodontic-treatment-planning-based-on-orthodontic-force-measurement-and-finite-element-method-before-implementation-a-case-study
#2
Jianlei Wu, Yunfeng Liu, Jianxing Zhang, Wei Peng
BACKGROUND: Orthodontic treatment planning (OTP) is primarily depended on clinical experiences of orthodontists at present, while equivocal OTP would increase the possibility of treatment failure. OBJECTIVE: The objective was to investigate a methodology for quantitatively evaluating OTP, using theoretical analyses, orthodontic forces measurement (OFM) and finite element method (FEM). METHODS: An OTP was theoretically designed based on a clinical case and forces on incisors in OTP were measured on a specialized platform...
April 27, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29751334/treatment-of-advanced-her2-positive-breast-cancer-2018-and-beyond
#3
REVIEW
Noam Pondé, Mariana Brandão, Georges El-Hachem, Emilie Werbrouck, Martine Piccart
In the 1980s the importance of HER2 signalling to the aberrant behaviour of a subset of breast cancer cells was recognized for the first time and, consequently, a hitherto unknown subtype of breast cancer - HER2-positive (HER2+) breast cancer was identified. The development of the anti-HER2 class of drugs, first with trastuzumab, followed closely by lapatinib, pertuzumab, and T-DM1, has improved outcomes dramatically. Nevertheless, metastatic HER2+ breast cancer remains an incurable disease and new therapeutic options are needed...
May 2, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29744754/less-is-more-similar-efficacy-in-three-sessions-and-seven-sessions-of-pulsed-dye-laser-treatment-in-infantile-port-wine-stain-patients
#4
Jiafang Zhu, Wenxin Yu, Tianyou Wang, Yijie Chen, Dongze Lyu, Lei Chang, Gang Ma, Xiaoxi Lin
Port-wine stains (PWS) affect 0.3 to 0.5% of newborns and pulsed dye laser (PDL) remains the treatment of choice. However, no reliable study regarding the benefits of more frequent has been conducted. We designed the present study to evaluate whether more frequent PDL treatments in infantile patients would achieve further lightening of erythema. We prospectively investigated 20 infants with PWS. Two adjacent sites were both treated for a 12-week duration and randomly allocated to be treated for seven sessions at 2-week intervals or three sessions at 6-week intervals...
May 10, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29744214/comparison-of-biofilm-formation-and-migration-of-streptococcus-mutans-on-tooth-roots-and-titanium-miniscrews
#5
Kittipong Laosuwan, Don Jeevanie Epasinghe, Zhaoming Wu, Wai Keung Leung, David William Green, Han Sung Jung
Periodontitis and peri-implantitis are inflammatory diseases caused by periodontal pathogenic bacteria leading to destruction of supporting periodontal/peri-implant tissue. However, the progression of inflammatory process of these two diseases is different. The bacterial biofilm is the source of bacteria during the inflammatory process. As the bacteria migrate down the surface of tooth or titanium implant, the inflammation spreads along with it. Streptococcus mutans has an important role in oral bacterial biofilm formation in early stage biofilm before the microbiota shift to late stage and become more virulent...
April 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29738816/can-red-light-5-aminolevulinic-photodynamic-therapy-cure-port-wine-stains-on-comb-animal-model
#6
Yongxian Lai, Haiyan Zhang, Minglei Wei, Jie Ji, Lei Shi, Peiru Wang, Bo Wang, Zheng Huang, Xiuli Wang
OBJECTIVE: To study the curative effect of red-light 5-Aminolevulinic photodynamic therapy(ALA-PDT) to port wine stains(PWS) on comb animal model. METHODS: 160 male cocks were randomly divided into 16 groups. The ALA only group was given ALA only topical or systemic application. Light only groups were only given 630 nm red light irradiation with different light density. ALA-PDT groups were given red light after the application of topical or systemic ALA. PDL group was given PDL irradiation...
May 5, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29735482/cd71-erythroid-suppressor-cells-promote-fetomaternal-tolerance-through-arginase-2-and-pdl-1
#7
Cole Delyea, Najmeh Bozorgmehr, Petya Koleva, Garett Dunsmore, Shima Shahbaz, Vivian Huang, Shokrollah Elahi
Survival of the allogeneic pregnancy depends on the maintenance of immune tolerance to paternal alloantigens at the fetomaternal interface. Multiple localized mechanisms contribute to the fetal evasion from the mother's immune rejection as the fetus is exposed to a wide range of stimulatory substances such as maternal alloantigens, microbes and amniotic fluids. In this article, we demonstrate that CD71+ erythroid cells are expanded at the fetomaternal interface and in the periphery during pregnancy in both humans and mice...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29734391/vibration-paradox-in-orthodontics-anabolic-and-catabolic-effects
#8
Mani Alikhani, Sarah Alansari, Mohammad A Hamidaddin, Chinapa Sangsuwon, Bandar Alyami, Soumya N Thirumoorthy, Serafim M Oliveira, Jeanne M Nervina, Cristina C Teixeira
Vibration in the form of High Frequency Acceleration (HFA) is anabolic on the craniofacial skeleton in the absence of inflammation. Orthodontic forces trigger an inflammation-dependent catabolic cascade that is crucial for tooth movement. It is unknown what effect HFA has on alveolar bone if applied during orthodontic treatment. The objectives of this study are to examine the effect of HFA on the rate of tooth movement and alveolar bone, and determine the mechanism by which HFA affects tooth movement. Adult Sprague Dawley rats were divided to control, orthodontic force alone (OTM), and different experimental groups that received the same orthodontic forces and different HFA regimens...
2018: PloS One
https://www.readbyqxmd.com/read/29730700/risk-seeking-for-losses-is-associated-with-5-httlpr-but-not-with-transient-changes-in-5-ht-levels
#9
Philipp T Neukam, Nils B Kroemer, Yacila I Deza Araujo, Lydia Hellrung, Shakoor Pooseh, Marcella Rietschel, Stephanie H Witt, Uwe Schwarzenbolz, Thomas Henle, Michael N Smolka
RATIONALE: Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIVES: To test whether high 5-HT levels decrease loss aversion, risk-seeking for gains, and risk-seeking for losses. METHODS: In a first session, 611 participants were genotyped for 5-HTTLPR and performed a mixed gambles (MGA) task and two probability discounting tasks for gains and losses, respectively (PDG/PDL)...
May 5, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29730290/cystathionine-gamma-lyase-h-2-s-contributes-to-osteoclastogenesis-during-bone-remodeling-induced-by-mechanical-loading
#10
Shenzheng Mo, Yongmei Hua
Hydrogen sulfide (H2 S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement. Recently, we found that osteoclasts could produce H2 S. However, whether H2 S modulates bone remodeling by affecting osteoclasts remains unclear. In this study, we found that CSE-H2 S was a dominant H2 S generating system in osteoclasts, while CBS did not generate H2 S...
May 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29726520/passive-mode-locking-resulting-from-weak-polarization-dependence-based-on-evanescent-field-interaction-with-a-monolayer-graphene-absorber
#11
Guiming Li, Yuan Chen, Xiaohong Yan, Luming Zhao
Weak polarization dependence based on evanescent field interaction with a monolayer graphene absorber is demonstrated. By covering single-layer graphene on the top of a fiber taper, the symmetry of the light field propagation was destroyed. Polarization-dependent loss (PDL) of 2 dB was obtained, and no saturable absorption was observed. Passive mode locking was achieved by using the graphene-covered fiber taper in a fiber laser. It is found that the weak PDL down to 2 dB is capable for achieving mode locking in a fiber laser...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29720325/histological-evaluation-of-periodontal-ligament-in-human-after-orthodontic-treatment-with-piezosurgery-and-monolateral-tooth-dislocation-and-ligament-distraction-technique-a-first-morphologic-and-histologic-evaluation
#12
D Bertossi, P F Galzignato, G Conti, U Luciano, A Gualdi, C Corega, P Faccioni, D Donadello, L Lanaro, E Grendene, A Sbarbati, D De Santis, R Nocini, P F Nocini
Traditional orthodontic tooth movement is based on the concept that application of a protracted force causes alveolar bone remodelling and adaptive changes in periodontal and dental tissues. Thus, if orthodontic tooth movement is described as a biological bone reaction to orthodontic forces mediated by the periodontal ligament (PDL), this event involves a series of sophisticated signal transduction processes that allows the PDL compression with specific histologic and biomolecular modifications. However, the preservation of the integrity of the PDL is generally difficult to achieve when it is associated with a long duration of orthodontic treatment...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29698133/viability-and-reproducibility-of-periodontal-ligament-cells-on-avulsed-teeth-stored-in-ham-s-f-10-solution
#13
Maryam Talebi, Iman Parisay, Jalil Tavakol Afshari, Arezoo Shajiei, Mostafa Sofiani Ghadim
OBJECTIVES: The purpose of the present study was to evaluate the efficacy of Ham's F-10 in maintaining the viability and reproducibility of PDL cells on avulsed teeth. STUDY DESIGN: Sixty mature, healthy extracted premolars were used. The experimental media used were Ham's F-10, Hank's balanced salt solution (HBSS), skim milk, and tap water (n = 15 specimens each). Cell viability was tested after 1, 3, 6, and 24 h storage in medium. Cell reproducibility was assessed by methyl-thiazol-tetrazolium (MTT) assay after1, 3, and 6 h storage in Ham's F-10, HBSS, and tap water...
April 26, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29694875/influence-of-micropatterning-on-human-periodontal-ligament-cells-behavior
#14
Lisha Zheng, Jingyi Jiang, Jinpeng Gui, Lingyu Zhang, Xiaoyi Liu, Yan Sun, Yubo Fan
The periodontal ligament (PDL) is highly ordered connective tissue located between the alveolar bone and cementum. An aligned and organized architecture is required for its physiological function. We applied micropatterning technology to arrange PDL cells in 10- or 20-μm-wide extracellular protein patterns. Cell and nuclear morphology, cytoskeleton, proliferation, differentiation, and matrix metalloproteinase system expression were investigated. Micropatterning clearly elongated PDL cells with a low cell-shape index and low spreading area...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29688731/molecular-recombination-phenomena-in-palladium-ii-based-self-assembled-complexes
#15
Sudhakar Ganta, Dillip K Chand
A series of self-assembled binuclear complexes (1-4) of Pd2 L'2 L2 composition are prepared by combination of selected cis-protected palladium(II) component cis-PdL' with equimolar amount of the nonchelating bidentate ligand 1,3-bis((pyridine-4-yl)methyl)urea, L. The cis-protecting unit L' crafted in the complexes [Pd2 (L')2 (L)2 ](NO3 )4 , 1-4, are ethylenediamine (en), tetramethylethylenediamine (tmeda), 2,2'-bipyridine (bpy), and 1,10-phenanthroline (phen), respectively. Complexation of palladium(II) with the ligand L, however, resulted in the self-assembled trinuclear complex [Pd3 (L)6 ](NO3 )6 , 5, of Pd3 L6 composition...
April 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29676592/pulsed-dye-laser-as-an-adjuvant-treatment-for-discoid-lupus-erythematosus-a-randomized-controlled-trial
#16
Pawinee Rerknimitr, Nucharin Tekacharin, Ratchathorn Panchaprateep, Jade Wititsuwannakul, Pattarin Tangtanatakul, Nattiya Hirankarn, Pravit Asawanonda
PURPOSE: To evaluate the efficacy and safety of PDL for DLE in a double blinded, randomized, controlled fashion. METHOD: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Treatments with the PDL (595nm) were delivered every 4 weeks for 4 consecutive months. The patients were evaluated at weeks 0, 4, 8, 12, 16 and 24. Erythema index (EI) and Texture index (TI) were obtained by Antera3D®...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29672601/expression-of-immune-checkpoint-regulators-cytotoxic-t-lymphocyte-antigen-4-ctla-4-and-programmed-death-ligand-1-pd-l1-in-female-breast-carcinomas
#17
Ari Kassardjian, Peter I Shintaku, Neda A Moatamed
BACKGROUND: Immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) have emerged as promising new targets for cancer therapeutics. While tumor expression of PD-L1 has been shown to have objective responses to anti-PD-L1 immunotherapies, the clinical implications of CTLA-4 expression in tumor cells or immune cells in the tumor microenvironment is still controversial. We investigated the expression of CTLA-4 and PD-L1 in human breast tumors and provided a scoring system for the systematic evaluation of CTLA-4 staining...
2018: PloS One
https://www.readbyqxmd.com/read/29665251/human-periodontal-fibroblasts-viability-stored-in-custodiol-%C3%A2-coconut-water-and-propolis-an-ex-vivo-study
#18
Lama Awawdeh, Rana Naman Haimour, Suhad Hussein Al-Jundi, Khaled Al-Qaoud
BACKGROUND/AIMS: Successful replantation of an avulsed tooth depends on the regeneration of periodontal ligament (PDL) attachment which is affected by the transport medium, dry time and storage time. Various storage media have been studied but the search for the optimum storage medium is still needed to determine the ideal material and storage time to maintain PDL cells. The aim of this study was to determine the ability of Custodiol® , coconut water from different stages of maturity and propolis as storage media for avulsed teeth by evaluating the viability of PDL cells for different time intervals...
April 17, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29655565/the-tolerogenic-role-of-ifn-%C3%AE
#19
REVIEW
Primož Rožman, Urban Švajger
Due to its extremely pleiotropic nature, the complex effects of IFN-γ exerted both on immune and non-immune cell types still remain only partially understood. The longstanding view of IFN-γ as being a predominantly inflammatory cytokine is constantly challenged by increasing demonstrations of its direct or indirect regulatory roles. Interferon-γ can exert tolerogenic effects on both innate and adaptive immune cell types, promoting tolerance of various antigen-presenting cells, and augmenting function and differentiation of regulatory T cells, respectively...
April 7, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29643764/the-idh1-mutation-induced-oncometabolite-2-hydroxyglutarate-may-affect-dna-methylation-and-expression-of-pd-l1-in-gliomas
#20
Luyan Mu, Yu Long, Changlin Yang, Linchun Jin, Haipeng Tao, Haitao Ge, Yifan E Chang, Aida Karachi, Paul S Kubilis, Gabriel De Leon, Jiping Qi, Elias J Sayour, Duane A Mitchell, Zhiguo Lin, Jianping Huang
Background: Malignant gliomas are heterogeneous brain tumors with the potential for aggressive disease progression, as influenced by suppressive immunoediting. Given the success and enhanced potential of immune-checkpoint inhibitors in immunotherapy, we focused on the connections between genetic alterations affected by IDH1 mutations and immunological landscape changes and PDL-1 expression in gliomas. Methods: Paired surgically resected tumors from lower-grade gliomas (LGGs) and glioblastomas (GBM) were investigated, and a genetic analysis of patients' primary tumor samples culled from TCGA datasets was performed...
2018: Frontiers in Molecular Neuroscience
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