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https://www.readbyqxmd.com/read/29152831/laser-treatment-of-cutaneous-angiokeratomas-a-systematic-review
#1
REVIEW
Jannett Nguyen, Lance W Chapman, Dorota Z Korta, Christopher B Zachary
Angiokeratomas can present therapeutic challenges, especially in cases of extensive lesions, where traditional surgical methods carry high risks of scarring and hemorrhage. Argon, pulsed dye (PDL), neodymium-doped yttrium aluminum garnet (Nd:YAG), copper vapor, potassium titanyl phosphate, carbon dioxide, and erbium-doped yttrium aluminum garnet (Er:YAG) lasers have emerged as alternative options. To review the use and efficacy of lasers in treating angiokeratomas. A PubMed search identified randomized clinical trials, cohort studies, case series, and case reports involving laser treatment of cutaneous angiokeratomas...
November 19, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29150026/regulatory-t-cells-friends-or-foe-in-human-mycobacterium-leprae-infection
#2
Ana T Chaves, Atvaldo F Ribeiro-Junior, Sandra Lyon, Nayara I Medeiros, Fábio Cassirer-Costa, Karina S Paula, Edilamar S Alecrim, Cristiane A S Menezes, Rodrigo Correa-Oliveira, Manoel O C Rocha, Juliana A S Gomes
Regulatory T cells (Tregs) are known to control immune responses by suppressing the antigen-presenting and effector T cells. Some mechanisms adopted by Tregs in combating Mycobacterium infections have been proposed. Nevertheless, in M. leprae infection, also known as leprosy or Hansen's disease, the role of Tregs has not been completely elucidated. Using multicolor flow cytometry, we evaluated the expression of different cell surface and intracellular molecules present in Tregs from peripheral blood samples of leprosy patients...
November 13, 2017: Immunobiology
https://www.readbyqxmd.com/read/29143932/forecasting-carbon-dioxide-emissions-based-on-a-hybrid-of-mixed-data-sampling-regression-model-and-back-propagation-neural-network-in-the-usa
#3
Xin Zhao, Meng Han, Lili Ding, Adrian Cantemir Calin
The accurate forecast of carbon dioxide emissions is critical for policy makers to take proper measures to establish a low carbon society. This paper discusses a hybrid of the mixed data sampling (MIDAS) regression model and BP (back propagation) neural network (MIDAS-BP model) to forecast carbon dioxide emissions. Such analysis uses mixed frequency data to study the effects of quarterly economic growth on annual carbon dioxide emissions. The forecasting ability of MIDAS-BP is remarkably better than MIDAS, ordinary least square (OLS), polynomial distributed lags (PDL), autoregressive distributed lags (ADL), and auto-regressive moving average (ARMA) models...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29143185/osteogenic-prospective-of-deriving-human-dental-stem-cells-in-collagen-matrix-boost
#4
Tong-Jing Fang, Ding-Han Wang, Chia-Yu Wang, Raju Poongodi, Nien-Hsien Liou, Jiang-Chuan Liu, Ming-Lun Hsu, Po-Da Hong, Shih-Fang Yang, Meng-Lun Liu
Stem cells derived from oral tissue represent a highly attractive alternative source for clinical bone regeneration because they can be collected by non-invasive or minimally invasive procedures. Herein, we describe the human dental stem cells (DSCs) deriving from buccal fat pads (BFP), dental pulp (DP) of impacted teeth, and periodontal ligaments (PDL) to obtain BFPSCs, DPSCs, and PDLSCs, respectively. Cells were purified with selected medium and expanded through passages in stem cell culture medium. Purified cells were characterized for stemness by their growth rate, immunostaining, and multilineage differentiation ability...
November 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29141064/port-wine-stains-a-focused-review-on-their-management
#5
Katelyn Mariko Updyke, Amor Khachemoune
<p>Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Typically, PWS progressively darken and may become hypertrophic or nodular without treatment. There are several treatment options available for PWS from topical antiangiogenic agents to laser therapies. Vascular-specific lasers are the gold standard in treating PWS and classically pulsed dye lasers are usually the treatment of choice...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141059/a-retrospective-study-on-efficacy-of-pulsed-dye-laser-and-intense-pulsed-light-for-the-treatment-of-facial-telangiectasia
#6
Lin Gao, Ni Gao, Wenting Song, Erle Dang, Rong Yin, Li Wang, Gang Wang
<p>Both pulsed dye laser (PDL) and intense pulsed light (IPL) systems have been demonstrated to be effective for treatment of facial telangiectasia, however there have been very few comparative studies between both treatments involving purely Asian patient populations. In this study, we performed a retrospective analysis to compare the efficacy of PDL and IPL systems for the treatment of facial telangiectasia. A total of 416 patients with facial telangiectasia who were treated by PDL or IPLs in our department from August 2012 to March 2015 were included in this study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29133660/predescemetocele-a-distinct-clinical-entity
#7
Priya Narang, Amar Agarwal, Dhivya Ashok Kumar
The case report incorporates a Fourier-domain optical coherence tomography (OCT) examination for demonstration of the existence of pre-Descemet's layer (PDL; Dua's layer) overlying a descemetocele and demonstrates predescemetocele as a separate clinical entity. The prospective analysis was done in two cases that had descemetocele, and OCT demonstrated the presence of PDL over an unruptured descemetocele that offers resilience and can be treated with an elective deep anterior lamellar keratoplasty or a penetrating keratoplasty...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29117898/the-contribution-of-immune-infiltrates-and-the-local-microenvironment-in-the-pathogenesis-of-osteosarcoma
#8
Marie-Françoise Heymann, Frédéric Lézot, Dominique Heymann
Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The local microenvironment defined several tumor niches controlling the tumor growth and cell extravasation. The immune infiltrate composes one of these niches. The immune environment of osteosarcoma is mainly composed by T-lymphocytes and macrophages but also contains other subpopulations including B-lymphocytes and mast cells. Osteosarcoma cells control the recruitment and differentiation of immune infiltrating cells and establish a local immune tolerant environment favorable to the tumor growth, drug resistance and the occurrence of metastases...
November 2, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29095118/screening-and-quantification-of-18-glucocorticoid-adulterants-from-herbal-pharmaceuticals-and-health-foods-by-hplc-and-confirmed-by-lc-q-tof-ms-ms
#9
Pengfei Jin, Xiaoli Liang, Xuejun Wu, Xiaorong He, Yongmei Kuang, Xin Hu
A procedure for the screening and quantification of 18 glucocorticoids, i.e. hydrocortisone sodium succinate (HSS), prednisolone (PDL), prednisone (PDS), hydrocortisone (HCS), methylprednisolone (MPS), betamethasone (BTM), dexamethasone (DXM), triamcinolone acetonide (TA), prednisolone acetate (PLA), hydrocortisone acetate (HA), fludrocortisone acetate (FA), prednisone acetate (PA), cortisone acetate (CA), dexamethasone acetate (DA), hydrocortisone butyrate (HB), triamcinolone acetonide acetate (TAA), fluocinonide (FN) and halcinonide (HC) from herbal pharmaceuticals and health foods was established and fully validated...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29073988/drug-policy-in-bulgaria
#10
Antoniya Dimova, Maria Rohova, Elka Atanasova, Paweł Kawalec, Katarzyna Czok
Bulgaria has a mixed public-private health care financing system. Health care is financed mainly from compulsory health insurance contributions and out-of-pocket payments. Out-of-pocket payments constitute a large share of the total health care expenditure (44.14% in 2014). The share of drugs expenditure for outpatient treatment was 42.3% of the total health care expenditure in 2014, covered mainly by private payments (78.6% of the total pharmaceutical expenditure). The drug policy is run by the Ministry of Health (MoH), the National Council on Prices and Reimbursement of Medicinal Products, and the Health Technology Assessment Commission...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29071027/antibacterial-effect-of-diode-laser-in-pulpectomy-of-primary-teeth
#11
Zahra Bahrololoomi, Reza Fekrazad, Shiva Zamaninejad
Introduction: Laser irradiation has been suggested as an adjunct to traditional methods of canal preparation but few studies are available on the antibacterial effect of diode laser in pulpectomy of primary teeth. The purpose of the present study is to investigate the antibacterial effect of diode laser in pulpectomy of primary teeth, in addition to define the optimal and harmless diode lasing conditions in the root canal. Methods: A total of 125 single rooted primary teeth were selected. After traditional canal cleaning, they were divided in 2 groups...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29070950/periodontal-ligament-injection-versus-routine-local-infiltration-for-nonsurgical-single-posterior-maxillary-permanent-tooth-extraction-comparative-double-blinded-randomized-clinical-study
#12
Mohammad H Al-Shayyab
AIM: The aim of this study was to evaluate the efficacy of, and patients' subjective responses to, periodontal ligament (PDL) anesthetic injection compared to traditional local-anesthetic infiltration injection for the nonsurgical extraction of one posterior maxillary permanent tooth. MATERIALS AND METHODS: All patients scheduled for nonsurgical symmetrical maxillary posterior permanent tooth extraction in the Department of Oral and Maxillofacial Surgery at the University of Jordan Hospital, Amman, Jordan over a 7-month period were invited to participate in this prospective randomized double-blinded split-mouth study...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29070883/combined-immunotherapy-with-anti-pdl-1-pd-1-and-anti-cd4-antibodies-cures-syngeneic-disseminated-neuroblastoma
#13
Valentina Rigo, Laura Emionite, Antonio Daga, Simonetta Astigiano, Maria Valeria Corrias, Concetta Quintarelli, Franco Locatelli, Silvano Ferrini, Michela Croce
Anti-PD-1 or anti-PD-L1 blocking monoclonal antibodies (mAbs) have shown potent anti-tumor effects in adult cancer patients and clinical studies have recently been started in pediatric cancers, including high-risk/relapsing neuroblastoma (NB). Therefore, we studied the effects of anti-PD-1/PD-L1 mAbs in two syngeneic models of disseminated NB generated by the injection of either Neuro2a or NXS2 cells, which express PD-L1. In addition, we tested the combination of these agents with the immune-enhancing cytokine IL-21, the Ecto-NTPDase inhibitor POM-1, an anti-CD25 mAb targeting Treg cells, or an anti-CD4 mAb...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068580/orthodontic-intrusion-of-periodontally-compromised-maxillary-incisors-3-dimensional-finite-element-method-analysis
#14
Liwia E Minch, Michał Sarul, Rafał Nowak, Beata Kawala, Joanna Antoszewska-Smith
BACKGROUND: Loading of the compromised periodontium with orthodontic forces produces different results than those achieved in patients with healthy periodontal support. Determining the force value at a level preventing further deterioration of the patient's periodontal status, thus delivering the most precisely individualized "dose" of loading, seems to be crucial for the successful intrusion of teeth with reduced periodontal support. OBJECTIVES: The aim of the study was to determine the range of force values efficiently intruding maxillary incisors without further compromising the initially-impaired periodontal status...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29067616/a-clinical-review-of-phototherapy-for-psoriasis
#15
REVIEW
Ping Zhang, Mei X Wu
Psoriasis is an autoimmune inflammatory skin disease. In the past several decades, phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp, arms and legs, and partial nail psoriasis. A variety of light/lasers with different mechanisms of action have been developed for psoriasis including ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), and so on. Because light/laser each has specific therapeutic and adverse effects, it is important to adequately choose the sources and parameters in management of psoriasis with different pathogenic sites, severities, and duration of the disorder...
October 24, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29063603/effects-of-paraoxonase-1-on-the-cytodifferentiation-and-mineralization-of-periodontal-ligament-cells
#16
R Masumoto, J Kitagaki, M Matsumoto, S Miyauchi, C Fujihara, M Yamashita, S Yamada, M Kitamura, S Murakami
BACKGROUND AND OBJECTIVE: Single nucleotide polymorphisms (SNPs) of paraoxonase 1 (PON1) are known to be associated with the pathogenesis of osteoporosis and periodontitis. However, the effects of PON1 on the osteoblastic differentiation of periodontal ligament (PDL) cells are unclear. In this study, we examined the effects of PON1 on the osteoblastic differentiation of PDL cells, and analysed the role of PON1 SNPs on the pathogenesis of aggressive periodontitis (AgP) in the Japanese population...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29055015/small-molecule%C3%A2-inhibition-of-pd-1-transcription-is-an-effective-alternative-to-antibody-blockade-in-cancer-therapy
#17
Alison Taylor, David Rothstein, Christopher E Rudd
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase GSK-3α/β, is a central regulator of PD-1 transcription in CD8+ T cells. Here, we show that the use of small molecule inhibitors of GSK-3α/β (GSK-3i) to reduce pcdc1 (PD-1) transcription and expression was as effective as anti-PD-1 and PDL-1 blocking antibodies in the control of B16 melanoma, or EL4 lymphoma, in primary tumor and metastatic settings...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29045803/chitosan-based-trilayer-scaffold-for-multitissue-periodontal-regeneration
#18
E M Varoni, S Vijayakumar, E Canciani, A Cochis, L De Nardo, G Lodi, L Rimondini, M Cerruti
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues-namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)-based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultaneous healing. We produced 2 porous compartments for bone and gingiva regeneration by cross-linking with genipin either medium molecular weight (MMW) or low molecular weight (LMW) CH and freeze-drying the resulting scaffolds...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29033087/micro-computed-tomography-versus-the-cross-sectioning-method-to-evaluate-dentin-defects-induced-by-different-mechanized-instrumentation-techniques
#19
Carolina Pessoa Stringheta, Rina Andréa Pelegrine, Augusto Shoji Kato, Laila Gonzales Freire, Elaine Faga Iglecias, Giulio Gavini, Carlos Eduardo da Silveira Bueno
INTRODUCTION: The objective of this study was to compare the methods of micro-computed tomography (micro-CT) and cross-sectioning followed by stereomicroscopy in assessing dentinal defects after instrumentation with different mechanized systems. METHODS: Forty mesial roots of mandibular molars were scanned and divided into 4 groups (n = 10): Group R, Reciproc; Group PTN, ProTaper Next; Group WOG, WaveOne Gold; Group PDL, ProDesign Logic. After instrumentation, the roots were once again submitted to a micro-CT scan, and then sectioned at 3, 6, and 9 mm from the apex, and assessed for the presence of complete and incomplete dentinal defects under a stereomicroscope...
October 12, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29028628/role-of-pdgf-bb-in-proliferation-differentiation-and-maintaining-stem-cell-properties-of-pdl-cells-in-vitro
#20
Zornitsa Mihaylova, Rozaliya Tsikandelova, Pavel Sanimirov, Natalia Gateva, Vanyo Mitev, Nikolay Ishkitiev
OBJECTIVE: Platelet-derived growth factor-BB (PDGF-BB) is one of the most abundant growth factors in platelet derived products and has been shown to stimulate regeneration after tissue injury. There is a population of mesenchymal stem cells (MSC) in human periodontal ligament (PDL) which can contribute to tissue regeneration under appropriate conditions. DESIGN: PDL cells were isolated and characterized using stem cell and differentiation markers via immunofluorescence and flow cytometry and then cultured in vitro and treated with different concentrations of PDGF-BB...
September 25, 2017: Archives of Oral Biology
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