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https://www.readbyqxmd.com/read/28631301/prevention-of-lupus-nephritis-development-in-nzb-nzw-mice-by-selective-blockade-of-cd28
#1
Laetitia Laurent, Awena Lefur, Rozenn Le Bloas, Mélanie Néel, Caroline Mary, Anne Moreau, Nicolas Poirier, Bernard Vanhove, Fadi Fakhouri
Systemic Lupus Erythematosus (SLE) is a chronic systemic inflammatory disease. Autoantibodies (autoAbs) against double-stranded DNA (ds DNA), the hallmark of lupus, are produced and maintained by the interaction between auto-reactive B cells and CD4(+) T cells. This interplay is controlled by the CD28/CD80-86/CTLA-4 axis. Here we investigated whether selective blockade of CD28-CD80/86 co-stimulatory interactions abrogates lupus nephritis development in a murine model of SLE. To this aim, NZB/NZW F1 mice were treated for 3 months, either with an anti-CD28 Fab' fragment or a control Fab'-IgG...
June 20, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28631261/distinct-post-translational-features-of-type-i-collagen-are-conserved-in-mouse-and-human-periodontal-ligament
#2
D M Hudson, M Garibov, D R Dixon, T Popowics, D R Eyre
BACKGROUND AND OBJECTIVE: Specifics of the biochemical pathways that modulate collagen cross-links in the periodontal ligament (PDL) are not fully defined. Better knowledge of the collagen post-translational modifications that give PDL its distinct tissue properties is needed to understand the pathogenic mechanisms of human PDL destruction in periodontal disease. In this study, the post-translational phenotypes of human and mouse PDL type I collagen were surveyed using mass spectrometry...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28612428/outcomes-and-prognostic-factors-that-influence-the-success-of-tooth-autotransplantation-in-children-and-adolescents
#3
Vasiliki Kafourou, Huei Jinn Tong, Peter Day, Nadine Houghton, R James Spencer, Monty Duggal
BACKGROUND/AIM: Tooth autotransplantation has been advocated for replacement of missing teeth, or teeth that are unsuitable for restoration. The aim of this study was to investigate the outcomes and prognostic factors that influenced the success of tooth transplantation in a paediatric population. MATERIALS AND METHODS: Data was extracted from the records of 75 patients (89 teeth). Demographic and prognostic factors were recorded and analyzed for the clinical and radiographic outcomes for periodontal ligament (PDL) and pulp healing of transplanted teeth...
June 14, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28604262/current-evidence-on-the-socket-shield-technique-a-systematic-review
#4
Amit Srikant Gharpure, Neel B Bhatavadekar
The recently popularised socket-shield technique involves intentional retention of a section of the remnant root at the time of immediate implant placement to preserve the buccal/proximal bone from resorption. The objective of this systematic review was to assess the literature available on the socket-shield technique and weigh its biological plausibility and long-term clinical prognosis. A Systematic Search was performed in PubMed-Medline, Embase, Web of Knowledge, Google Scholar and Cochrane Central for clinical/ animal studies up to April 2017...
June 12, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28597116/secretory-leukocyte-protease-inhibitor-regulates-human-periodontal-ligament-cell-production-of-pro-inflammatory-cytokines
#5
Daniel Svensson, Alexandra Aidoukovitch, Emma Anders, Daniel Jönsson, Daniel Nebel, Bengt-Olof Nilsson
OBJECTIVE: Regulation of immune-like cell properties of periodontal ligament (PDL) cells is not understood. We investigate the importance of secretory leukocyte protease inhibitor (SLPI) for production of pro-inflammatory cytokines in human PDL cells. MATERIALS AND METHODS: PDL cells were isolated from teeth extracted for orthodontic reasons. Cellular location of SLPI was investigated by immunocytochemistry. Cytokine transcript and protein expression were assessed by quantitative real-time RT-PCR and Western blotting...
June 8, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28590058/transgelin-mediates-transforming-growth-factor-%C3%AE-1-induced-proliferation-of-human-periodontal-ligament-cells
#6
H Mitarai, N Wada, D Hasegawa, S Yoshida, M Sonoda, A Tomokiyo, S Hamano, S Serita, H Mizumachi, H Maeda
BACKGROUND AND OBJECTIVE: Human periodontal ligament cells (HPDLCs) express transforming growth factor-β1 (TGF-β1) that regulates differentiation and proliferation, and plays key roles in homeostasis of PDL tissue. Transgelin is a cytoskeleton-associated protein with an Smad-binding element in its gene promoter region. In this study, we examined the localization and potential function of transgelin in PDL tissue and cells. MATERIAL AND METHODS: Microarray analysis of HPDLC lines (2-14, 2-23 and 2-52) was performed...
June 7, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28578892/proteome-expression-in-human-periodontal-ligament-after-delayed-hypothermic-preservation
#7
Sin-Yeon Cho, Junhee Park, Won-Yoon Chung, Euiseong Kim, Il-Young Jung, Seong-Ho Choi, Kwang-Kyun Park, Seung-Jong Lee
INTRODUCTION: Previous occasional successes after delayed replantation suggest that the presence of viable cells may not be the only factor for successful periodontal regeneration in delayed replantation. Various other factors such as proteins or the extracellular matrix (ECM) may play a role in this process. The purpose of this study was to characterize changes in the proteome components of periodontal ligament (PDL) tissue after hypothermic preservation of the tooth. METHODS: Extracted teeth were divided into 4 groups: immediate sampling, sampling after 1 week of preservation at 4°C, sampling after 2 weeks of preservation at 4°C, and sampling after 1 week of dry storage at room temperature as a negative control...
June 1, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28578703/effects-of-platelet-rich-plasma-prp-on-human-gingival-fibroblast-osteoblast-and-periodontal-ligament-cell-behaviour
#8
Eizaburo Kobayashi, Masako Fujioka-Kobayashi, Anton Sculean, Vivianne Chappuis, Daniel Buser, Benoit Schaller, Forenc Dőri, Richard J Miron
BACKGROUND: The use of platelet rich plasma (PRP, GLO) has been used as an adjunct to various regenerative dental procedures. The aim of the present study was to characterize the influence of PRP on human gingival fibroblasts, periodontal ligament (PDL) cells and osteoblast cell behavior in vitro. METHODS: Human gingival fibroblasts, PDL cells and osteoblasts were cultured with conditioned media from PRP and investigated for cell migration, proliferation and collagen1 (COL1) immunostaining...
June 2, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28561950/poly-n-4-aminobutyl-acrylamide-as-mimetic-polylysine-for-improving-survival-and-differentiation-of-cerebellar-granule-neurons
#9
Yu-Hsin Wang, Shao-Hsuan Chang, Daxen Mau-Hsu, Jyh-Horng Wang, Tai-Horng Young
Poly(N-(4-aminobutyl)-acrylamide) (P4Am) and poly-d-lysine (PDL) possess the same butylamine side chain. The main difference is the peptide structure, which is in the main chain of PDL but in the side chain of P4Am. PDL has been extensively used in the preparation of neuronal cultures. We assumed neurons are sensitive enough to distinguish such structure difference so these two cationic polymers were compared at serial coating concentrations for culturing cerebellar granule neurons from 7-day-old Wistar rats in this study...
May 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28560407/tensile-strength-suppresses-the-osteogenesis-of-periodontal-ligament-cells-in-inflammatory-microenvironments
#10
Chaofan Sun, Fen Liu, Shendan Cen, Lijiao Chen, Yi Wang, Hao Sun, Hui Deng, Rongdang Hu
The present study aimed to investigate the role of orthodontic force in osteogenesis differentiation, matrix deposition and mineralization in periodontal ligament cells (PDLCs) cells in inflammatory microenvironments. The mesenchymal origin of PDLCs was confirmed by vimentin and cytokeratin staining. PDLCs were exposed to inflammatory cytokines (5 ng/ml IL‑1β and 10 ng/ml TNF‑α) and/or tensile strength (0.5 Hz, 12% elongation) for 12, 24 or 48 h. Cell proliferation and tensile strength‑induced cytokine expression were assessed by MTT assay and ELISA, respectively...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28547733/comparative-evaluation-of-post-traumatic-periodontal-ligament-cell-viability-using-three-storage-media
#11
V V Kokkali, V Bendgude, G Sharangpani
AIM: To evaluate the potential of milk, coconut water and buttermilk in maintaining periodontal ligament cell (PDL) viability. METHODS: Freshly extracted premolars (55) were divided into three experimental groups each having 15 teeth and the negative and positive control groups which had 5 teeth per group. The teeth in the experimental groups were immersed in their respective storage medium for a period of 75 min before the laboratory procedures were performed...
May 25, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28544936/effect-of-follicular-dendritic-cell-secreted-protein-on-gene-expression-of-human-periodontal-ligament-cells
#12
Lin Xiang, Na Xin, Ying Yuan, Xiaogang Hou, Junwei Chen, Na Wei, Ping Gong
OBJECTIVE: The objective of this study was to investigate the specific roles of follicular dendritic cell secreted protein (FDC-SP), a protein exists in saliva, in the inhibition of calcium precipitation during periodontal regeneration, as well as affect phenotype expression of human periodontal ligament cells (hPDLCs) during the differentiation process. DESIGN: To investigate this, we applied microarray technology to identify gene expression changes in hPDLCs transfected with FDC-SP and then clustered them according to their biological functions...
May 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28544606/effects-of-tooth-storage-media-on-periodontal-ligament-preservation
#13
Md Riasat Hasan, Hiroaki Takebe, Nazmus Shalehin, Nobuko Obara, Takashi Saito, Kazuharu Irie
BACKGROUND / AIMS: An easily available tooth storage medium is required to preserve a tooth after avulsion. Milk and Hank's balanced salt solution (HBSS) are recommended as tooth storage media, and egg white is also reported to be comparable with milk. The aim of the present study was to histologically and immunohistochemically evaluate the effect of different tooth storage media on the periodontal ligament (PDL) of extracted teeth. MATERIAL AND METHODS: This experiment used HBSS, milk and egg white as tooth storage media...
May 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28543887/treatment-of-venous-lake-with-multi-wavelength-595-and-1064-nm-lasers-in-asian-fitzpatrick-skin-type-iv-patients
#14
Jing Yang, Xiaohong Guo, Xiaorong Tong, Juan Tao
BACKGROUND: Multi-wavelength lasers are reportedly useful for treating venous lake (VL) in Caucasian patients. However, the same parameters may not be safe for Asian patients with Fitzpatrick skin type (FST) IV. PURPOSE: Report experience with using multi-wavelength laser for VL treatment in Asian patients with FST IV. METHODS: Seventeen episodes of VL in 15 Chinese patients with FST IV were treated. 595-nm pulsed dye (PDL) laser followed by 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser were administered...
May 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28542267/discerning-morpho-anatomical-physiological-and-molecular-multiformity-in-cultivated-and-wild-genotypes-of-lentil-with-reconciliation-to-salinity-stress
#15
Dharmendra Singh, Chandan Kumar Singh, Shanti Kumari, Ram Sewak Singh Tomar, Sourabh Karwa, Rajendra Singh, Raja Bahadur Singh, Susheel Kumar Sarkar, Madan Pal
One hundred and sixty two genotypes of different Lens species were screened for salinity tolerance in hydroponics at 40, 80 and 120 mM sodium chloride (NaCl) for 30 d. The germination, seedling growth, biomass accumulation, seedling survivability, salinity scores, root and shoot anatomy, sodium ion (Na+), chloride ion (Cl-) and potassium ion (K+) concentrations, proline and antioxidant activities were measured to evaluate the performance of all the genotypes. The results were compared in respect of physiological (Na+, K+ and Cl-) and seed yield components obtained from field trials for salinity stress conducted during two years...
2017: PloS One
https://www.readbyqxmd.com/read/28531913/methods-of-isolation-and-characterization-of-stem-cells-from-different-regions-of-oral-cavity-using-markers-a-systematic-review
#16
REVIEW
Kavarthapu Avinash, Sankari Malaippan, Jayakumar Nadathur Dooraiswamy
Background: Periodontitis is a destructive inflammatory disorder of the periodontium caused by the destruction of periodontal tissues namely the PDL, cementum, alveolar bone, and gingiva. Once these tissues are lost, the foremost goal of periodontal therapy is to regenerate the diseased tissues if possible to their original form, architecture, and function. Various regenerative procedures were employed and still a gap was found in achieving the goal. As stem cells are characterized by their ability to self-renew and differentiate to produce specialized cells, there could be a possibility of using them for regenerative therapy...
May 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28528603/a-retrospective-study-of-multiple-sequential-light-and-laser-sources-to-activate-aminolevulinic-acid-in-the-treatment-of-acne-vulgaris
#17
Daniel P Friedmann, Mitchel P Goldman, Sabrina G Fabi, Isabella Guiha
Reports of the sequential use of multiple light and laser sources for topical 5-aminolevulinic acid (ALA) activation in photodynamic therapy (PDT) of inflammatory acne vulgaris are lacking. The authors sought to retrospectively compare field-directed ALA-PDT with blue light only, blue light + pulsed dye laser (PDL), blue light + intense pulsed light (IPL), blue light + PDL + IPL, or blue light + red light + PDL + IPL for inflammatory acne of the face or upper trunk. Results showed a trend toward greater patient-reported improvement with comparable tolerability using multiple, sequential light sources in ALA-PDT for acne vulgaris, albeit not statistically significant...
2017: Skinmed
https://www.readbyqxmd.com/read/28528141/portland-cement-induces-human-periodontal-ligament-cells-to-differentiate-by-upregulating-mir-146a
#18
Min-Ching Wang, Li-Yin Yeh, Wen-Yu Shih, Wan-Chun Li, Kuo-Wei Chang, Shu-Chun Lin
BACKGROUND/PURPOSE: Bioaggregates such as Portland cement (PC) can be an economical alternative for mineral trioxide aggregate (MTA) with additional benefit of less discoloration. MTA has been known to induce differentiations of several dental cells. MicroRNAs are important regulators of biological processes, including differentiation, physiologic homeostasis, and disease progression. This study is to explore how PC enhances the differentiation of periodontal ligament (PDL) cells in microRNAs level...
May 18, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28522749/expansion-of-tumor-infiltrating-cd8-t-cells-expressing-pd-1-improves-the-efficacy-of-adoptive-t-cell-therapy
#19
Sarita M Fernandez-Poma, Diego Salas-Benito, Teresa Lozano, Noelia Casares, José-Ignacio Riezu-Boj, Uxua Mancheño, Edurne Elizalde, Diego Alignani, Natalia Zubeldia, Itziar Otano, Enrique Conde, Pablo Sarobe, Juan J Lasarte, Sandra Hervas-Stubbs
Recent studies have found that tumor-infiltrating lymphocytes (TIL) expressing PD-1 can recognize autologous tumor cells, suggesting that cells derived from PD-1+ TIL can be used in adoptive T cell therapy (ACT). However, no study thus far has evaluated the antitumor activity of PD-1-selected TIL in vivo. In two mouse models of solid tumors, we show that PD-1 allows identification and isolation of tumor-specific TIL without previous knowledge of their antigen specificities. Importantly, despite the high proportion of tumor-reactive T cells present in bulk CD8 TIL before expansion, only T cell products derived from sorted PD-1+, but not from PD-1- or bulk CD8 TIL, specifically recognized tumor cells...
May 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28513726/delocalized-and-localized-donating-accepting-mn-c-interactions-in-half-sandwich-cyclopentadienyl-and-pentadienyl-complexes
#20
Josué Solís-Huitrón, Noé Zúñiga-Villarreal, Diego Martínez-Otero, José Enrique Barquera-Lozada
The widely used cyclopentadienyl (Cp) ligand and the pentadienyl (Pdl) ligand have very similar molecular orbitals (MOs) but they have significantly different chemical behavior. The extensively mixing of the MOs in the Pdl ligand has prevented a quantitative explanation of the observed differences between these two ligands. In a series of synthesized close/open half sandwich manganese phosphine carbonyls, the quantum theory of atoms in molecules and the interacting quantum atom model allow us to quantify the accepting-donating capacities of both ligands and to break down the M-dienyl bond into individual atomic interactions...
May 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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