keyword
MENU ▼
Read by QxMD icon Read
search

Pdl

keyword
https://www.readbyqxmd.com/read/28230773/programmed-death-ligand-1-pd-l1-tumor-expression-is-associated-with-a-better-prognosis-and-diabetic-disease-in-triple-negative-breast-cancer-patients
#1
Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Federica Rao, Valentina Peluso, Rossella De Cecio, Michela Piezzo, Gabriella Landi, Michelino De Laurentiis, Monica Cantile, Maurizio Di Bonito
Triple Negative Breast Cancers (TNBC) subtype is an aggressive disease with poor clinical outcome. The only treatment available is surgery followed by chemotherapy or radiotherapy. Programmed death-ligand 1 (PD-L1) is a trans-membrane protein expressed on a wide variety of cells including immune cells, epithelial and vascular endothelial cells. Recently, PD-1/PD-L1 pathway signaling was described as an adaptive immune resistance mechanism enacted by the tumor cells to evade the immune response. Its presence on tumor cell membranes, acquired for this reason, through time, is an important prognostic value...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28227956/a-wirelessly-powered-homecage-with-animal-behavior-analysis-and-closed-loop-power-control
#2
Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Donald Rainnie, Chia-Chun Hsu, Teresa E Madsen, Morgan Tinkler, Daniel Canales, Zheyuan Wang, S Abdollah Mirbozorgi, Maysam Ghovanloo, Yaoyao Jia
This paper presents a new EnerCage-homecage system, EnerCage-HC2, for longitudinal electrophysiology data acquisition experiments on small freely moving animal subjects, such as rodents. EnerCage-HC2 is equipped with multi-coil wireless power transmission (WPT), closed-loop power control, bidirectional data communication via Bluetooth Low Energy (BLE), and Microsoft Kinect® based animal behavior tracking and analysis. The EnerCage-HC2 achieves a homogeneous power transfer efficiency (PTE) of 14% on average, with ~42 mW power delivered to the load (PDL) at a nominal height of 7 cm by the closed-loop power control mechanism...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227885/orthodontic-force-simulation-of-tooth-pdl-bone-complex-under-archwire-loading
#3
Xinwen Zhou, Zeyang Xia, Yangzhou Gan, Dongxia Zhang, Jing Xiong, Peng Fang, Guanglin Li, Qunfei Zhao, Xinwen Zhou, Zeyang Xia, Yangzhou Gan, Dongxia Zhang, Jing Xiong, Peng Fang, Guanglin Li, Qunfei Zhao, Zeyang Xia, Peng Fang, Xinwen Zhou, Dongxia Zhang, Yangzhou Gan, Guanglin Li, Jing Xiong, Qunfei Zhao
Orthodontic force simulation is very important for the guidance of clinical orthodontic treatment. Previous works were mainly conducted by directly loading the force on a single or a few teeth. However, in clinic, the orthodontic force is provided by loading orthodontic appliances, and there currently is no appropriate way to measure the force on the teeth provided by the loaded appliances. This study presents a method to simulate the orthodontic force of a whole Tooth-Periodontal Ligament-Bone Complex (TPBC) by directly loading the archwire to the dentition applying the finite element method...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227511/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#4
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Maysam Ghovanloo, Byunghun Lee, Bruce Ash, Xingyuan Tong, Pyungwoo Yeon, Abdollah Mirbozorgi, Helmut Eckhardt
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm(3) neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226904/optimal-wireless-receiver-structure-for-omnidirectional-inductive-power-transmission-to-biomedical-implants
#5
Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani
In order to achieve omnidirectional inductive power transmission to biomedical implants, the use of several orthogonal coils in the receiver side (Rx) has been proposed in the past. In this paper, the optimal Rx structure for connecting three orthogonal Rx coils and the power management is found to achieve the maximum power delivered to the load (PDL) in the presence of any Rx coil tilting. Unlike previous works, in which a separate power management has been used for each coil to deliver power to the load, different resonant Rx structures for connecting three Rx coils to a single power management are studied...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223136/wnt3%C3%AE-and-transforming-growth-factor-%C3%AE-induce-myofibroblast-differentiation-from-periodontal-ligament-cells-via-different-pathways
#6
Hui Xu, Yao He, Jian Q Feng, Rui Shu, Zhe Liu, Jingyu Li, Yating Wang, Yang Xu, Huan Zeng, Xin Xu, Zichao Xiang, Chaoran Xue, Ding Bai, Xianglong Han
Myofibroblasts are specialized cells that play a key role in connective tissue remodeling and reconstruction. Alpha-smooth muscle actin (α-SMA), vimentin and tenascin-C are myofibroblast phenotype, while α-SMA is the phenotypic marker. The observation that human periodontal ligament cells (hPDLCs) differentiate into myofibroblasts under orthodontic force has provided a new perspective for understanding of the biological and biomechanical mechanisms involved in orthodontic tooth movement. However, the cell-specific molecular mechanisms leading to myofibroblast differentiation in the periodontal ligament (PDL) remain unclear...
February 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28222387/baicalein-enhances-the-osteogenic-differentiation-of-human-periodontal-ligament-cells-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#7
Li-Jiao Chen, Bi-Bo Hu, Xin-Lian Shi, Man-Man Ren, Wen-Bin Yu, Sheng-Dan Cen, Rong-Dang Hu, Hui Deng
OBJECTIVE: Periodontium regeneration is one of the most important processes for periodontitis therapy. Human periodontal ligament cells (hPDLCs) play a vital role in the repair and regeneration of periodontal tissues. Our study aimed to investigated the mechanisms underlying the promotion of hPLDCs osteogenic differentiation by baicalein. DESIGN: hPDLCs were obtained from periodontal ligament (PDL) tissues by primary culture. The MTT assay was used to determine the growth curves of hPDLCs treated with different concentrations of baicalein (1...
February 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28221099/sphingomyelin-phosphodiesterase-3-enhances-cytodifferentiation-of-periodontal-ligament-cells
#8
S Miyauchi, J Kitagaki, R Masumoto, A Imai, K Kobayashi, A Nakaya, S Kawai, C Fujihara, Y Asano, M Yamashita, M Yanagita, S Yamada, M Kitamura, S Murakami
Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors analyzed the effects of Smpd3 on the cytodifferentiation of human PDL (HPDL) cells. The authors found that Smpd3 increases the mRNA expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells...
March 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28208234/the-influence-of-traumatic-occlusion-on-the-repair-process-for-teeth-following-subluxation
#9
Marina Fuzette Amaral, Caio Vinicius Lourenço Debortoli, Wilson Roberto Poi, Sônia Regina Panzarini, Daniela Atili Brandini
BACKGROUND/AIM: Traumatic occlusion can cause morphofunctional alterations that interfere in the homeostasis of the periodontium The aim of this study was to assess the influence of traumatic occlusion (TO) on the periodontal repair process for teeth following subluxation. MATERIALS AND METHODS: Ninety Wistar rats aged 12 weeks were divided into three groups: control (C), subluxation (S) and subluxation with traumatic occlusion (S+TO). Subluxation was created with an impact force of 900 cN applied by a tensiometer and TO was created with a direct composite resin filling...
February 16, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28194153/nasal-polyp-derived-mesenchymal-stromal-cells-exhibit-lack-of-immune-associated-molecules-and-high-levels-of-stem-progenitor-cells-markers
#10
Pedro Wey Barbosa de Oliveira, Rogério Pezato, Juan Sebastian Henao Agudelo, Claudina Angela Perez-Novo, Wim Vanden Berghe, Niels Olsen Câmara, Danilo Candido de Almeida, Luís Carlos Gregorio
Mesenchymal stromal cells (MSCs) are considered adult progenitor stem cells and have been studied in a multitude of tissues. In this context, the microenvironment of nasal polyp tissue has several inflammatory cells, but their stroma compartment remains little elucidated. Hence, we isolated MSCs from nasal polyps Polyp-MSCs (PO-MSCs) and compared their molecular features and gene expression pattern with bone marrow-derived MSCs (BM-MSCs). Initially, both PO-MSCs and BM-MSCs were isolated, cultivated, and submitted to morphologic, differentiation, phenotypic, immunosuppressive, and gene expression assays...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28191762/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#11
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28191657/prospective-open-label-rater-blinded-and-self-controlled-pilot-study-of-the-treatment-of-proliferating-superficial-infantile-hemangiomas-with-0-5-topical-timolol-cream-versus-595-nm-pulsed-dye-laser
#12
Hanru Ying, Yun Zou, Wenxin Yu, Yajing Qiu, Gang Ma, Lei Chang, Yifei Gu, Dongze Lyu, Xiaoxi Lin
Topical timolol and 595-nm pulsed dye laser (PDL) are both widely used in the treatment of superficial infantile hemangiomas (IH). However, to date, there is no reliable study comparing the therapeutic outcomes between the two treatment options. We designed the present study to evaluate and compare the efficacy and safety of timolol cream and PDL in the treatment of superficial proliferating IH. Twenty-one patients with superficial IH were included in the study. Each lesion was divided into two regions; one part was treated with 0...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28187321/development-and-parameter-identification-of-a-visco-hyperelastic-model-for-the-periodontal-ligament
#13
Huixiang Huang, Wencheng Tang, Qiyan Tan, Bin Yan
The present study developed and implemented a new visco-hyperelastic model that is capable of predicting the time-dependent biomechanical behavior of the periodontal ligament. The constitutive model has been implemented into the finite element package ABAQUS by means of a user-defined material subroutine (UMAT). The stress response is decomposed into two constitutive parts in parallel which are a hyperelastic and a time-dependent viscoelastic stress response. In order to identify the model parameters, the indentation equation based on V-W hyperelastic model and the indentation creep model are developed...
January 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28186730/engineered-hydrogen-bonded-glycopolymer-capsules-and-their-interactions-with-antigen-presenting-cells
#14
Kristian Kempe, Sue D Xiang, Paul Wilson, Md Arifur Rahim, Yi Ju, Michael R Whittaker, David M Haddleton, Magdalena Plebanski, Frank Caruso, Thomas P Davis
Hollow glycopolymer microcapsules were fabricated by hydrogen-bonded layer-by-layer (LbL) assembly, and their interactions with a set of antigen presenting cells (APCs), including dendritic cells (DCs), macrophages (MACs), and myeloid derived suppressor cells (MDSCs), were investigated. The glycopolymers were obtained by cascade postpolymerization modifications of poly(oligo(2-ethyl-2-oxazoline methacrylate)-stat-glycidyl methacrylate) involving the modification of the glycidyl groups with propargylamine and the subsequent attachment of mannose azide by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)...
February 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28185198/validation-of-anti-mouse-pdl-1-goat-polyclonal-antibody-staining-with-mouse-pdl-1-in-situ-hybridization-on-adjacent-sections-of-cell-pellets-and-mouse-tumors
#15
Jacob Ricca, Mesruh Turkekul, Afsar Barlas, Dmitry Yarilin, Sho Fujisawa, Ning Fan, Matthew Brendel, Dmitriy Zamarin, Jedd D Wolchok, Katia Manova-Todorova
Finding a valid antibody to detect mouse programmed death ligand 1 (PDL-1) by immunohistochemistry or immunofluorescence staining has been notoriously difficult. Successful validation of an antibody requires the use of multiple detection methods with the ability to compare appropriate positive and negative controls. Here, we describe in detail the protocols used to validate a mouse-specific PDL-1 antibody used in immunohistochemistry staining with an mRNA in situ hybridization on adjacent sections of mouse B16 tumor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28177531/recruitment-of-bone-marrow-derived-cells-to-the-periodontal-ligament-via-the-stromal-cell-derived-factor-1-c-x-c-chemokine-receptor-type-4-axis
#16
M Kaku, M Kitami, J M Rosales Rocabado, T Ida, Y Akiba, K Uoshima
BACKGROUND/OBJECTIVES: The periodontal ligament (PDL) is a non-mineralized connective tissue that exists between the alveolar bone and root surface cementum and plays important roles in tooth function. The PDL harbors a remarkable reserve of multipotent stem cells, which maintain various types of cells. However, the sources of these stem cells, other than their developmental origin, are not well understood. MATERIAL AND METHODS: To elucidate the recruitment of bone marrow (BM)-derived stem cells in the PDL, green fluorescent protein (GFP)-expressing BM-derived cells were transplanted into the femoral BM of immunodeficient rats, and the distribution and expression of stem cell markers in the PDL were analyzed in vivo...
February 8, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28168994/oxidative-stress-and-no-generation-in-the-rat-pancreatitis-induced-by-pancreatic-duct-ligation
#17
Igor Buchwalow, Jürgen Schnekenburger, Dmitri Atiakshin, Vera Samoilova, Eduard Wolf, Werner Boecker, Katharina Tiemann
The interaction between nitric oxide (NO) and superoxides is critical in the development of an acute pancreatitis. Previously, we reported that the expression of superoxides and of the NO-generating enzyme (NO synthase, NOS) was up-regulated in the human pancreatitis, especially within the exocrine compartment indicating an exceptional susceptibility of the exocrine parenchyma to oxidative stress. The aim of the present study was to compare the regulation of NO signalling pathways in the human pancreatitis and in an animal model of an acute pancreatitis induced by pancreatic duct ligation (PDL) in rats...
February 3, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28167967/enhancement-of-anti-inflammatory-and-osteogenic-abilities-of-mesenchymal-stem-cells-via-cell-to-cell-adhesion-to-periodontal-ligament-derived-fibroblasts
#18
Keita Suzuki, Naoyuki Chosa, Shunsuke Sawada, Naoki Takizawa, Takashi Yaegashi, Akira Ishisaki
Mesenchymal stem cells (MSCs) are involved in anti-inflammatory events and tissue repair; these functions are activated by their migration or homing to inflammatory tissues in response to various chemokines. However, the mechanism by which MSCs interact with other cell types in inflammatory tissue remains unclear. We investigated the role of periodontal ligament fibroblasts (PDL-Fs) in regulating the anti-inflammatory and osteogenic abilities of bone marrow-derived- (BM-) MSCs. The expression of monocyte chemotactic protein- (MCP-)1 was significantly enhanced by stimulation of PDL-Fs with inflammatory cytokines...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28165889/force-induced-h2s-by-pdlscs-modifies-osteoclastic-activity-during-tooth-movement
#19
F Liu, F Wen, D He, D Liu, R Yang, X Wang, Y Yan, Y Liu, X Kou, Y Zhou
Hydrogen sulfide (H2S), a gasotransmitter, has been recently linked to mesenchymal stem cell (MSC) function and bone homeostasis. Periodontal ligament stem cells (PDLSCs) are the main MSCs in PDL, which respond to mechanical force to induce physiological activities during orthodontic tooth movement (OTM). However, it is unknown whether mechanical force might induce endogenous H2S production by PDLSCs to regulate alveolar bone homeostasis. Here, we used a mouse OTM model to demonstrate that orthodontic force-induced endogenous H2S production in PDL tissue was associated with macrophage accumulation and osteoclastic activity in alveolar bone...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28165872/nampt-is-an-essential-regulator-of-ra-mediated-periodontal-inflammation
#20
D Kim, G Lee, Y H Huh, S Y Lee, K H Park, S Kim, J Kim, J Koh, J Ryu
Recent studies have indicated a potential correlation between rheumatoid arthritis (RA) and periodontal inflammation. We undertook this study to verify whether RA mediates periodontitis-like phenotypes in experimental mouse models of RA and to explore the role of nicotinamide phosphoribosyltransferase (NAMPT) in periodontal inflammation during RA pathogenesis. Periodontal inflammation and alveolar bone loss have been reported in mice with collagen-induced arthritis (CIA) and in genetically modified tumor necrosis factor-α (TNF-α) transgenic (TG) mouse models...
February 1, 2017: Journal of Dental Research
keyword
keyword
12464
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"