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https://www.readbyqxmd.com/read/28522749/expansion-of-tumor-infiltrating-cd8-t-cells-expressing-pd-1-improves-the-efficacy-of-adoptive-t-cell-therapy
#1
Sarita M Fernandez-Poma, Diego Salas-Benito, Teresa Lozano, Noelia Casares, José-Ignacio Riezu-Boj, Uxua Mancheño, Edurne Elizalde, Diego Alignani, Natalia Zubeldia, Itziar Otano, Enrique Conde, Pablo Sarobe, Juan J Lasarte, Sandra Hervas-Stubbs
Recent studies have found that tumor-infiltrating lymphocytes (TIL) expressing PD-1 can recognize autologous tumor cells, suggesting that cells derived from PD-1+ TIL can be used in adoptive T cell therapy (ACT). However, no study thus far has evaluated the antitumor activity of PD-1-selected TIL in vivo. In two mouse models of solid tumors, we show that PD-1 allows identification and isolation of tumor-specific TIL without previous knowledge of their antigen specificities. Importantly, despite the high proportion of tumor-reactive T cells present in bulk CD8 TIL before expansion, only T cell products derived from sorted PD-1+, but not from PD-1- or bulk CD8 TIL, specifically recognized tumor cells...
May 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28513726/delocalized-and-localized-donating-accepting-mn-c-interactions-in-half-sandwich-cyclopentadienyl-and-pentadienyl-complexes
#2
Josué Solís-Huitrón, Noé Zúñiga-Villarreal, Diego Martínez-Otero, José Enrique Barquera-Lozada
The widely used cyclopentadienyl (Cp) ligand and the pentadienyl (Pdl) ligand have very similar molecular orbitals (MOs) but they have significantly different chemical behavior. The extensively mixing of the MOs in the Pdl ligand has prevented a quantitative explanation of the observed differences between these two ligands. In a series of synthesized close/open half sandwich manganese phosphine carbonyls, the quantum theory of atoms in molecules and the interacting quantum atom model allow us to quantify the accepting-donating capacities of both ligands and to break down the M-dienyl bond into individual atomic interactions...
May 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28512498/treatment-outcomes-of-full-pulpotomy-as-an-alternative-to-tooth-extraction-in-molars-with-hyperplastic-irreversible-pulpitis-a-case-report
#3
Saeed Asgary, Prashant Verma, Ali Nosrat
Root canal therapy (RCT) is a common and successful treatment for irreversible pulpitis due to carious pulp exposure in mature permanent teeth. However, it is often an expensive procedure, may require multiple appointments, and requires a high level of training and clinical skill, specifically in molars. Uninsured patients, low-income patients, and patients with limited access to specialist care often elect for extraction of restorable teeth with irreversible pulpitis. There is a need for an alternative affordable treatment option to preserve their teeth and maintain chewing function...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28511358/the-degree-of-phosphorus-saturation-of-agricultural-soils-in-germany-current-and-future-risk-of-diffuse-p-loss-and-implications-for-soil-p-management-in-europe
#4
P Fischer, R Pöthig, M Venohr
Decades of intensive agricultural production with excessive application of P fertilizer have resulted in the accumulation of P in soils, threatening water bodies in most industrialized countries with eutrophication. In our study, we elucidated the risk of P loss of German agricultural soils by transforming provided monitoring data of plant-available P determined by the calcium-acetate-lactate (PCAL) and double-lactate method (PDL) into the degree of phosphorus saturation (DPS). As water-soluble phosphorus (WSP) is correlated to DPS, we derived a pedotransfer function (PTF) between PCAL and WSP for different soil types...
May 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28499975/intracortical-signal-processing-of-periodontal-ligament-sensations-in-rat
#5
Aoi Minoda, Naoko Mizoguchi, Masayuki Kobayashi, Naoto Suda, Kazuyo Muramoto
The somatosensory information from the orofacial region, including the periodontal ligament (PDL), is processed in a manner that differs from that used for other body somatosensory information in the related cortices. It was reported that electrical stimulation to rat PDL elicited activation of the insular oral region (IOR) and the primary (S1) and secondary (S2) somatosensory cortices. However, the physiological relationship between S1 and S2/IOR is not well understood. To address this issue, we performed in vivo optical imaging using a voltage-sensitive dye...
May 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28488345/patterns-of-pd-1-pd-l1-and-pd-l2-expression-in-pediatric-solid-tumors
#6
Navin Pinto, Julie R Park, Erin Murphy, Jennifer Yearley, Terri McClanahan, Lakshmanan Annamalai, Douglas S Hawkins, Erin R Rudzinski
BACKGROUND: Significant antitumor effects have been observed in a variety of malignancies via blockade of immune checkpoints. Interaction of programmed death 1 (PD-1) with its ligands PD-L1 and PD-L2 suppresses T-cell function and restricts immune-mediated tumor killing. We examined expression of these proteins in children with solid tumors, as expression may serve as biomarkers of response to this class of drugs. METHODS: Sections cut from formalin-fixed paraffin-embedded (FFPE) tissue blocks were processed and evaluated for PD-1, PD-L1, and PD-L2 by immunohistochemistry (IHC) as well as by mRNA expression...
May 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28481696/contribution-of-the-pdl-to-osteotomy-repair-and-implant-osseointegration
#7
X Pei, L Wang, C Chen, X Yuan, Q Wan, J A Helms
Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of "immediate" implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28481010/dynamics-of-big-bubble-formation-in-deep-anterior-lamellar-keratoplasty-by-the-big-bubble-technique-in%C3%A2-vitro-studies
#8
Harminder S Dua, Lana A Faraj, Mohamed B Kenawy, Saief AlTaan, Mohamed S Elalfy, Tarek Katamish, Dalia G Said
PURPOSE: To examine the movement of air injected in the cornea in simulated deep anterior lamellar keratoplasty (DALK), from the needle tip to the formation of different types of big bubbles (BB) and to ascertain how air travels through the stroma and pre-Descemet's layer [Dua's layer (PDL)] to create a type-1 (air between PDL and deep stroma) and type-2BB (air between PDL and Descemet's membrane). METHODS: Air was injected in 57 sclerocorneal discs and the passage recorded...
May 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28476944/impact-of-age-on-outcomes-with-immunotherapy-for-patients-with-melanoma
#9
Allison S Betof, Ryan D Nipp, Anita Giobbie-Hurder, Romany A N Johnpulle, Krista Rubin, Samuel M Rubinstein, Keith T Flaherty, Donald P Lawrence, Douglas B Johnson, Ryan J Sullivan
BACKGROUND: Monoclonal antibodies (mAb) targeting PD-1/PD-L1 have revolutionized melanoma treatment, yet data regarding effectiveness and tolerability across age groups is limited. We sought to determine the impact of age on overall survival (OS), progression-free survival (PFS), and rates of immune-mediated toxicities in patients treated with anti-PD-1/anti-PD-L1 mAb at two academic medical centers. METHODS: We retrospectively collected data on all patients with metastatic melanoma treated with anti-PD-1/PD-L1 mAb between May 2009 and April 2015...
May 5, 2017: Oncologist
https://www.readbyqxmd.com/read/28476206/primary-cortical-neurons-on-pmcs-tio2-films-towards-bio-hybrid-memristive-device-a-morpho-functional-study
#10
Alessandro Roncador, Aura Matilde Jimenez-Garduño, Laura Pasquardini, Giovanni Giusti, Nicola Cornella, Lorenzo Lunelli, Cristina Potrich, Ruben Bartali, Lucrezia Aversa, Roberto Verucchi, Mauro Dalla Serra, Silvia Caponi, Salvatore Iannotta, Paolo Macchi, Carlo Musio
We report a comprehensive study of the biocompatibility and neurocompatibility of titanium dioxide films (TiO2) prepared by Pulsed Microplasma Cluster Source (PMCS). This technique uses supersonic pulsed beams seeded by clusters of the metal oxide synthesized in a plasma discharge. The final stoichiometry of the TiO2 thin films is tuned changing the gas mixture, achieving stoichiometric or oxygen overstoichiometric films. All the films showed consistent biocompatibility and a spontaneous absorption of poly-d-lysine (PDL) that favors the adhesion and growth of murine cortical neurons...
April 26, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28476202/periodontal-ligament-entheses-and-their-adaptive-role-in-the-context-of-dentoalveolar-joint-function
#11
REVIEW
Jeremy D Lin, Andrew T Jang, Michael P Kurylo, Jonathan Hurng, Feifei Yang, Lynn Yang, Arvin Pal, Ling Chen, Sunita P Ho
OBJECTIVE: The dynamic bone-periodontal ligament (PDL)-tooth fibrous joint consists of two adaptive functionally graded interfaces (FGI), the PDL-bone and PDL-cementum that respond to mechanical strain transmitted during mastication. In general, from a materials and mechanics perspective, FGI prevent catastrophic failure during prolonged cyclic loading. This review is a discourse of results gathered from literature to illustrate the dynamic adaptive nature of the fibrous joint in response to physiologic and pathologic simulated functions, and experimental tooth movement...
May 2, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28463085/low-intensity-pulsed-ultrasound-reduces-periodontal-atrophy-in-occlusal-hypofunctional-teeth
#12
Yuki Kasahara, Risa Usumi-Fujita, Jun Hosomichi, Sawa Kaneko, Yuji Ishida, Naoki Shibutani, Yasuhiro Shimizu, Asuka Okito, Shuji Oishi, Yoichiro Kuma, Hiroyuki Yamaguchi, Takashi Ono
OBJECTIVE: To clarify whether low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional periodontal ligament (PDL) and interradicular alveolar bone (IRAB). MATERIALS AND METHODS: Twelve-week-old male Sprague-Dawley rats were divided into three groups (n = 5 each): a normal occlusion (C) group, an occlusal hypofunction (H) group, and an occlusal hypofunction group subjected to LIPUS (HL) treatment. Hypofunctional occlusion of the maxillary first molar (M1) of the H and HL groups was induced by the bite-raising technique...
May 2, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28463045/mitigation-of-epidermal-growth-factor-receptor-inhibitor-induced-side-effects-utilizing-melanin-and-vascular-specific-lasers-a-case-report-series
#13
Karen Y Kuo, Bernice Kwong, Zakia Rahman
The advent of targeted chemotherapy has led to the emergence of new dermatologic toxicities. We sought to use lasers and light devices to treat recalcitrant cutaneous adverse effects related to cancer treatment. Three stage III or IV cancer patients with cutaneous complications due to epidermal growth factor receptor (EGFR) inhibitors were treated with melanin and vascular-specific laser and light technologies. Two patients reported reduction in papulopustular eruption following pulse dye laser (PDL) treatment...
March 2, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28447749/dental-and-periodontal-phenotypes-of-dlx2-overexpression-in-mice
#14
Jiewen Dai, Jiawen Si, Ningjuan Ouyang, Jianfei Zhang, Dandan Wu, Xudong Wang, Guofang Shen
Distal-less homeobox 2 (Dlx2) is a member of the homeodomain family of transcription factors and is important for the development of cranial neural crest cells (CNCCs)‑derived craniofacial tissues. Previous studies revealed that Dlx2 was expressed in the cementum and a targeted null mutation disrupted tooth development in mice. However, whether Dlx2 overexpression may impair in vivo tooth morphogenesis remains to be elucidated. The present study used a transgenic mouse model to specifically overexpress Dlx2 in neural crest cells in order to identify the dental phenotypes in mice by observation, micro‑computed tomography and histological examination...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447362/randomized-controlled-trial-split-faced-study-of-595-nm-pulsed-dye-laser-in-the-treatment-of-acne-vulgaris-and-acne-erythema-in-adolescents-and-early-adulthood
#15
Ramrada Lekwuttikarn, Therdpong Tempark, Susheera Chatproedprai, Siriwan Wananukul
The high prevalence of acne vulgaris in teenagers has increased comorbidities. Lasers offer alternative options for acne treatment because they have rapid action, low systemic adverse effects, and do not require everyday treatment. To study the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood, we designed a blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm(3) pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study in patients with mild to moderate acne by comparing the laser-treated and non-treated side...
April 26, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28444165/proinflammatory-mediators-related-to-orthodontically-induced-periapical-root-resorption-in-rat-mandibular-molars
#16
Yoshiro Matsumoto, Siripen Sringkarnboriboon, Takashi Ono
Objectives: The early phase of orthodontic tooth movement involves acute inflammatory response that may induce bone resorption. The aim of this study was to localize and quantify cells in the periodontium expressing proinflammatory mediators during orthodontically induced periapical root resorption of the rat mandibular molars. Materials and methods: The levels of proinflammatory cytokines interleukin-1 (IL-1) α and β, tumor necrosis factor-α (TNF-α), inflammatory enzymes cyclooxygenase (COX) 1 and 2, and their product prostaglandin E2 (PGE2) in the root resorption site were compared to those in the corresponding area of the untreated periodontal ligament (PDL) of physiologically drifting teeth...
April 22, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28440742/leptin-overexpression-in-bone-marrow-stromal-cells-promotes-periodontal-regeneration-in-a-rat-model-of-osteoporosis
#17
Baoyu Zheng, Jun Jiang, Yuling Chen, Minkui Lin, Zhibin Du, Yin Xiao, Kai Luo, Fuhua Yan
BACKGROUND: Osteoporosis (OP) is associated with widespread periodontitis and impaired periodontal healing. However, there is a lack of information about the outcomes of regenerative approaches under the influence of OP. This study investigated the effect of leptin (LEP) overexpression on the regenerative potential of bone marrow stromal cells (BMSCs) in an osteoporotic rat periodontal fenestration defect model. METHODS: Rat BMSCs were transfected with adenoviruses harboring the human (h) LEP gene...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28435369/in-vitro-comparative-evaluation-of-different-storage-media-hank-s-balanced-salt-solution-propolis-aloe-vera-and-pomegranate-juice-for-preservation-of-avulsed-tooth
#18
Prashant Babaji, Mahesh Melkundi, Raghu Devanna, B S Suresh, Vishwajit Rampratap Chaurasia, P V Gopinath
OBJECTIVES: Prognosis of the avulsed teeth is mostly affected by extraoral dry period and storage medium used to store teeth before reimplantation. However, ability of storage media can affect cell viability and success of treatment. Various storage media were tried with some success. The present study was undertaken to comparatively evaluate the efficacy of hank's balanced salt solution (HBSS), propolis, Aloe vera, and pomegranate juice (PJ) in preserving the vitality of periodontal ligament (PDL) cells of avulsed teeth...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434170/establishment-and-characterization-of-novel-epithelial-like-cell-lines-derived-from-human-periodontal-ligament-tissue-in-vitro
#19
Kallapat Tansriratanawong, Hiroshi Ishikawa, Junko Toyomura, Soh Sato
In this study, novel human-derived epithelial-like cells (hEPLCs) lines were established from periodontal ligament (PDL) tissues, which were composed of a variety of cell types and exhibited complex cellular activities. To elucidate the putative features distinguishing these from epithelial rest of Malassez (ERM), we characterized hEPLCs based on cell lineage markers and tight junction protein expression. The aim of this study was, therefore, to establish and characterize hEPLCs lines from PDL tissues. The hEPLCs were isolated from PDL of third molar teeth...
April 22, 2017: Human Cell
https://www.readbyqxmd.com/read/28416159/new-finite-element-study-protocol-clinical-simulation-of-orthodontic-tooth-movement
#20
Antoine Bouton, Yohann Simon, Florent Goussard, Luciano Teresi, Vittorio Sansalone
The aim of this work was to model tooth movement in a more clinically-exact fashion, thanks to the use of new IT tools and imaging systems (cone-beam). Image segmentation and 3D reconstruction now enable us to model the anatomy realistically, while finite element (FE) analysis makes it possible to evaluate stresses and their distribution on the level of the tooth, the periodontal ligament (PDL) and the alveolar bone when a force is applied. The principle is to monitor tooth movement by obtaining optical impressions at each stage of treatment...
April 13, 2017: International Orthodontics
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