keyword
MENU ▼
Read by QxMD icon Read
search

Alt

keyword
https://www.readbyqxmd.com/read/28945041/-dynamic-serum-metabolomics-study-of-liver-injury-in-rats-caused-by-polygonum-multifulorum
#1
Zhi-Jie Ma, Qi Li, Kui-Jun Zhao, Jia-Bo Wang, Xiao-He Xiao
Liquid chromatography-mass spectrometry method was used for determination of metabolic fingerprint spectrum in rat serum, and the method of multivariate statistical analysis was used to compare the metabolism spectrum difference and screen significantly related biomarkers. The dynamic change trend was investigated at the same time. The dynamic metabonomics changes of liver injury in rats caused by Polygonum multifulorum(PM) were investigated; significantly related biomarkers were found and their dynamic change trend was investigated to provide basis for internal mechanism and early clinical diagnosis...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945035/-preliminary-research-on-effect-of-licorice-processed-tripterygium-wilfordii-on-reducing-liver-toxicity
#2
Xiao-Mei Zhao, Man Gong, Jie-Ming Dong, Jia-Bo Wang, Xiao-He Xiao, Kui-Jun Zhao, Zhi-Jie Ma
To explore the effect of the licorice-processed Tripterygium wilfordii on reducing the liver toxicity. In animal experiments, the liver toxicity of T. wilfordii was evaluated both before and after processing, and the differences in liver tissue biopsy, serum biochemical indexes and inflammatory cell factor among blank group, T. wilfordii group and licorice-processed T. wilfordii group were observed. Liver tissue biopsy results showed that liver tissue injury was obvious in T. wilfordii group, and no obvious injury was found in licorice-processed T...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28943788/production-of-formula-see-text-and-formula-see-text-mesons-up-to-high-transverse-momentum-in-pp-collisions-at-2-76-tev
#3
S Acharya, D Adamová, M M Aggarwal, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, N Ahmad, S U Ahn, S Aiola, A Akindinov, S N Alam, D S D Albuquerque, D Aleksandrov, B Alessandro, D Alexandre, R Alfaro Molina, A Alici, A Alkin, J Alme, T Alt, I Altsybeev, C Alves Garcia Prado, M An, C Andrei, H A Andrews, A Andronic, V Anguelov, C Anson, T Antičić, F Antinori, P Antonioli, R Anwar, L Aphecetche, H Appelshäuser, S Arcelli, R Arnaldi, O W Arnold, I C Arsene, M Arslandok, B Audurier, A Augustinus, R Averbeck, T Awes, M D Azmi, A Badalà, Y W Baek, S Bagnasco, R Bailhache, R Bala, A Baldisseri, M Ball, R C Baral, A M Barbano, R Barbera, F Barile, L Barioglio, G G Barnaföldi, L S Barnby, V Barret, P Bartalini, K Barth, J Bartke, E Bartsch, M Basile, N Bastid, S Basu, B Bathen, G Batigne, A Batista Camejo, B Batyunya, P C Batzing, I G Bearden, H Beck, C Bedda, N K Behera, I Belikov, F Bellini, H Bello Martinez, R Bellwied, L G E Beltran, V Belyaev, G Bencedi, S Beole, A Bercuci, Y Berdnikov, D Berenyi, R A Bertens, D Berzano, L Betev, A Bhasin, I R Bhat, A K Bhati, B Bhattacharjee, J Bhom, L Bianchi, N Bianchi, C Bianchin, J Bielčík, J Bielčíková, A Bilandzic, G Biro, R Biswas, S Biswas, J T Blair, D Blau, C Blume, G Boca, F Bock, A Bogdanov, L Boldizsár, M Bombara, G Bonomi, M Bonora, J Book, H Borel, A Borissov, M Borri, E Botta, C Bourjau, P Braun-Munzinger, M Bregant, T A Broker, T A Browning, M Broz, E J Brucken, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, P Buhler, S A I Buitron, P Buncic, O Busch, Z Buthelezi, J B Butt, J T Buxton, J Cabala, D Caffarri, H Caines, A Caliva, E Calvo Villar, P Camerini, A A Capon, F Carena, W Carena, F Carnesecchi, J Castillo Castellanos, A J Castro, E A R Casula, C Ceballos Sanchez, P Cerello, B Chang, S Chapeland, M Chartier, J L Charvet, S Chattopadhyay, S Chattopadhyay, A Chauvin, M Cherney, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, S Cho, P Chochula, K Choi, M Chojnacki, S Choudhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Colamaria, D Colella, A Collu, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, M E Connors, J G Contreras, T M Cormier, Y Corrales Morales, I Cortés Maldonado, P Cortese, M R Cosentino, F Costa, S Costanza, J Crkovská, P Crochet, E Cuautle, L Cunqueiro, T Dahms, A Dainese, M C Danisch, A Danu, D Das, I Das, S Das, A Dash, S Dash, S De, A De Caro, G de Cataldo, C de Conti, J de Cuveland, A De Falco, D De Gruttola, N De Marco, S De Pasquale, R D De Souza, H F Degenhardt, A Deisting, A Deloff, C Deplano, P Dhankher, D Di Bari, A Di Mauro, P Di Nezza, B Di Ruzza, M A Diaz Corchero, T Dietel, P Dillenseger, R Divià, Ø Djuvsland, A Dobrin, D Domenicis Gimenez, B Dönigus, O Dordic, T Drozhzhova, A K Dubey, A Dubla, L Ducroux, A K Duggal, P Dupieux, R J Ehlers, D Elia, E Endress, H Engel, E Epple, B Erazmus, F Erhardt, B Espagnon, S Esumi, G Eulisse, J Eum, D Evans, S Evdokimov, L Fabbietti, J Faivre, A Fantoni, M Fasel, L Feldkamp, A Feliciello, G Feofilov, J Ferencei, A Fernández Téllez, E G Ferreiro, A Ferretti, A Festanti, V J G Feuillard, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, E M Fiore, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, A Francescon, A Francisco, U Frankenfeld, G G Fronze, U Fuchs, C Furget, A Furs, M Fusco Girard, J J Gaardhøje, M Gagliardi, A M Gago, K Gajdosova, M Gallio, C D Galvan, P Ganoti, C Gao, C Garabatos, E Garcia-Solis, K Garg, P Garg, C Gargiulo, P Gasik, E F Gauger, M B Gay Ducati, M Germain, P Ghosh, S K Ghosh, P Gianotti, P Giubellino, P Giubilato, E Gladysz-Dziadus, P Glässel, D M Goméz Coral, A Gomez Ramirez, A S Gonzalez, V Gonzalez, P González-Zamora, S Gorbunov, L Görlich, S Gotovac, V Grabski, L K Graczykowski, K L Graham, L Greiner, A Grelli, C Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, N Grion, J M Gronefeld, F Grosa, J F Grosse-Oetringhaus, R Grosso, L Gruber, F R Grull, F Guber, R Guernane, B Guerzoni, K Gulbrandsen, T Gunji, A Gupta, R Gupta, I B Guzman, R Haake, C Hadjidakis, H Hamagaki, G Hamar, J C Hamon, J W Harris, A Harton, D Hatzifotiadou, S Hayashi, S T Heckel, E Hellbär, H Helstrup, A Herghelegiu, G Herrera Corral, F Herrmann, B A Hess, K F Hetland, H Hillemanns, B Hippolyte, J Hladky, B Hohlweger, D Horak, S Hornung, R Hosokawa, P Hristov, C Hughes, T J Humanic, N Hussain, T Hussain, D Hutter, D S Hwang, R Ilkaev, M Inaba, M Ippolitov, M Irfan, V Isakov, M Ivanov, V Ivanov, V Izucheev, B Jacak, N Jacazio, P M Jacobs, M B Jadhav, S Jadlovska, J Jadlovsky, S Jaelani, C Jahnke, M J Jakubowska, M A Janik, P H S Y Jayarathna, C Jena, S Jena, M Jercic, R T Jimenez Bustamante, P G Jones, A Jusko, P Kalinak, A Kalweit, J Kamin, J H Kang, V Kaplin, S Kar, A Karasu Uysal, O Karavichev, T Karavicheva, L Karayan, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, P Khan, S A Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, M M Kielbowicz, B Kileng, D Kim, D W Kim, D J Kim, H Kim, J S Kim, J Kim, M Kim, M Kim, S Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, G Kiss, J L Klay, C Klein, J Klein, C Klein-Bösing, S Klewin, A Kluge, M L Knichel, A G Knospe, C Kobdaj, M Kofarago, T Kollegger, A Kolojvari, V Kondratiev, N Kondratyeva, E Kondratyuk, A Konevskikh, M Kopcik, M Kour, C Kouzinopoulos, O Kovalenko, V Kovalenko, M Kowalski, G Koyithatta Meethaleveedu, I Králik, A Kravčáková, M Krivda, F Krizek, E Kryshen, M Krzewicki, A M Kubera, V Kučera, C Kuhn, P G Kuijer, A Kumar, J Kumar, L Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, S Kushpil, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, C Lagana Fernandes, I Lakomov, R Langoy, K Lapidus, C Lara, A Lardeux, A Lattuca, E Laudi, R Lavicka, L Lazaridis, R Lea, L Leardini, S Lee, F Lehas, S Lehner, J Lehrbach, R C Lemmon, V Lenti, E Leogrande, I León Monzón, P Lévai, S Li, X Li, J Lien, R Lietava, S Lindal, V Lindenstruth, C Lippmann, M A Lisa, V Litichevskyi, H M Ljunggren, W J Llope, D F Lodato, P I Loenne, V Loginov, C Loizides, P Loncar, X Lopez, E López Torres, A Lowe, P Luettig, M Lunardon, G Luparello, M Lupi, T H Lutz, A Maevskaya, M Mager, S Mahajan, S M Mahmood, A Maire, R D Majka, M Malaev, I Maldonado Cervantes, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, V Manko, F Manso, V Manzari, Y Mao, M Marchisone, J Mareš, G V Margagliotti, A Margotti, J Margutti, A Marín, C Markert, M Marquard, N A Martin, P Martinengo, J A L Martinez, M I Martínez, G Martínez García, M Martinez Pedreira, A Mas, S Masciocchi, M Masera, A Masoni, A Mastroserio, A M Mathis, A Matyja, C Mayer, J Mazer, M Mazzilli, M A Mazzoni, F Meddi, Y Melikyan, A Menchaca-Rocha, E Meninno, J Mercado Pérez, M Meres, S Mhlanga, Y Miake, M M Mieskolainen, D L Mihaylov, K Mikhaylov, L Milano, J Milosevic, A Mischke, A N Mishra, D Miśkowiec, J Mitra, C M Mitu, N Mohammadi, B Mohanty, M Mohisin Khan, E Montes, D A Moreira De Godoy, L A P Moreno, S Moretto, A Morreale, A Morsch, V Muccifora, E Mudnic, D Mühlheim, S Muhuri, M Mukherjee, J D Mulligan, M G Munhoz, K Münning, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, C J Myers, B Naik, R Nair, B K Nandi, R Nania, E Nappi, A Narayan, M U Naru, H Natal da Luz, C Nattrass, S R Navarro, K Nayak, R Nayak, T K Nayak, S Nazarenko, A Nedosekin, R A Negrao De Oliveira, L Nellen, S V Nesbo, F Ng, M Nicassio, M Niculescu, J Niedziela, B S Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, P Nomokonov, G Nooren, J C C Noris, J Norman, A Nyanin, J Nystrand, H Oeschler, S Oh, A Ohlson, T Okubo, L Olah, J Oleniacz, A C Oliveira Da Silva, M H Oliver, J Onderwaater, C Oppedisano, R Orava, M Oravec, A Ortiz Velasquez, A Oskarsson, J Otwinowski, K Oyama, Y Pachmayer, V Pacik, D Pagano, P Pagano, G Paić, P Palni, J Pan, A K Pandey, S Panebianco, V Papikyan, G S Pappalardo, P Pareek, J Park, W J Park, S Parmar, A Passfeld, S P Pathak, V Paticchio, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, L G Pereira, H Pereira Da Costa, D Peresunko, E Perez Lezama, V Peskov, Y Pestov, V Petráček, V Petrov, M Petrovici, C Petta, R P Pezzi, S Piano, M Pikna, P Pillot, L O D L Pimentel, O Pinazza, L Pinsky, D B Piyarathna, M Pł Oskoń, M Planinic, J Pluta, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, B Polichtchouk, N Poljak, W Poonsawat, A Pop, H Poppenborg, S Porteboeuf-Houssais, J Porter, J Pospisil, V Pozdniakov, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, G Puddu, P Pujahari, V Punin, J Putschke, H Qvigstad, A Rachevski, S Raha, S Rajput, J Rak, A Rakotozafindrabe, L Ramello, F Rami, D B Rana, R Raniwala, S Raniwala, S S Räsänen, B T Rascanu, D Rathee, V Ratza, I Ravasenga, K F Read, K Redlich, A Rehman, P Reichelt, F Reidt, X Ren, R Renfordt, A R Reolon, A Reshetin, K Reygers, V Riabov, R A Ricci, T Richert, M Richter, P Riedler, W Riegler, F Riggi, C Ristea, M Rodríguez Cahuantzi, K Røed, E Rogochaya, D Rohr, D Röhrich, P S Rokita, F Ronchetti, L Ronflette, P Rosnet, A Rossi, A Rotondi, F Roukoutakis, A Roy, C Roy, P Roy, A J Rubio Montero, O V Rueda, R Rui, R Russo, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, S Saarinen, S Sadhu, S Sadovsky, K Šafařík, S K Saha, B Sahlmuller, B Sahoo, P Sahoo, R Sahoo, S Sahoo, P K Sahu, J Saini, S Sakai, M A Saleh, J Salzwedel, S Sambyal, V Samsonov, A Sandoval, D Sarkar, N Sarkar, P Sarma, M H P Sas, E Scapparone, F Scarlassara, R P Scharenberg, H S Scheid, C Schiaua, R Schicker, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, S Schuchmann, J Schukraft, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, R Scott, M Šefčík, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, K Senosi, S Senyukov, E Serradilla, P Sett, A Sevcenco, A Shabanov, A Shabetai, O Shadura, R Shahoyan, A Shangaraev, A Sharma, A Sharma, M Sharma, M Sharma, N Sharma, A I Sheikh, K Shigaki, Q Shou, K Shtejer, Y Sibiriak, S Siddhanta, K M Sielewicz, T Siemiarczuk, D Silvermyr, C Silvestre, G Simatovic, G Simonetti, R Singaraju, R Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, M Slupecki, N Smirnov, R J M Snellings, T W Snellman, J Song, M Song, F Soramel, S Sorensen, F Sozzi, E Spiriti, I Sputowska, B K Srivastava, J Stachel, I Stan, P Stankus, E Stenlund, J H Stiller, D Stocco, P Strmen, A A P Suaide, T Sugitate, C Suire, M Suleymanov, M Suljic, R Sultanov, M Šumbera, S Sumowidagdo, K Suzuki, S Swain, A Szabo, I Szarka, A Szczepankiewicz, M Szymanski, U Tabassam, J Takahashi, G J Tambave, N Tanaka, M Tarhini, M Tariq, M G Tarzila, A Tauro, G Tejeda Muñoz, A Telesca, K Terasaki, C Terrevoli, B Teyssier, D Thakur, S Thakur, D Thomas, R Tieulent, A Tikhonov, A R Timmins, A Toia, S Tripathy, S Trogolo, G Trombetta, V Trubnikov, W H Trzaska, B A Trzeciak, T Tsuji, A Tumkin, R Turrisi, T S Tveter, K Ullaland, E N Umaka, A Uras, G L Usai, A Utrobicic, M Vala, J Van Der Maarel, J W Van Hoorne, M van Leeuwen, T Vanat, P Vande Vyvre, D Varga, A Vargas, M Vargyas, R Varma, M Vasileiou, A Vasiliev, A Vauthier, O Vázquez Doce, V Vechernin, A M Veen, A Velure, E Vercellin, S Vergara Limón, R Vernet, R Vértesi, L Vickovic, S Vigolo, J Viinikainen, Z Vilakazi, O Villalobos Baillie, A Villatoro Tello, A Vinogradov, L Vinogradov, T Virgili, V Vislavicius, A Vodopyanov, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, D Voscek, D Vranic, J Vrláková, B Wagner, J Wagner, H Wang, M Wang, D Watanabe, Y Watanabe, M Weber, S G Weber, D F Weiser, J P Wessels, U Westerhoff, A M Whitehead, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, M C S Williams, B Windelband, W E Witt, S Yalcin, P Yang, S Yano, Z Yin, H Yokoyama, I-K Yoo, J H Yoon, V Yurchenko, V Zaccolo, A Zaman, C Zampolli, H J C Zanoli, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, M Zhalov, H Zhang, X Zhang, Y Zhang, C Zhang, Z Zhang, C Zhao, N Zhigareva, D Zhou, Y Zhou, Z Zhou, H Zhu, J Zhu, X Zhu, A Zichichi, A Zimmermann, M B Zimmermann, S Zimmermann, G Zinovjev, J Zmeskal
The invariant differential cross sections for inclusive [Formula: see text] and [Formula: see text] mesons at midrapidity were measured in pp collisions at [Formula: see text] TeV for transverse momenta [Formula: see text] GeV/c and [Formula: see text] GeV/c, respectively, using the ALICE detector. This large range in [Formula: see text] was achieved by combining various analysis techniques and different triggers involving the electromagnetic calorimeter (EMCal). In particular, a new single-cluster, shower-shape based method was developed for the identification of high-[Formula: see text] neutral pions, which exploits that the showers originating from their decay photons overlap in the EMCal...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28943446/evaluation-of-genotoxicity-and-subchronic-toxicity-of-the-standardized-leaves-infusion-extract-of-copaifera-malmei-harms-in-experimental-models
#4
Eduarda Pavan, Amilcar Sabino Damazo, Larissa Maria Scalon Lemos, Bulus Adzu, Sikiru Olaitan Balogun, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Copaifera malmei Harms (Fabaceae), known mainly as óleo-mirim, is a native and endemic plant found in the states of Mato Grosso and Goiás of Brazil. The plant's leaves infusion is popularly used by riverine communities of the northern Araguaia microregion, Mato Grosso, Brazil, for the treatment of gastric ulcers and inflammatory diseases of the respiratory tract. The gastric antiulcer activity of the standardized leaves infusion extract of Copaifera malmei (SIECm) in rodents has been reported...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28943299/interaction-of-quindoline-derivative-with-telomeric-repeat-containing-rna-induces-telomeric-dna-damage-response-in-cancer-cells-through-inhibition-of-telomeric-repeat-factor-2
#5
Yan Zhang, Deying Zeng, Jiaojiao Cao, Mingxue Wang, Bing Shu, Guotao Kuang, Tian-Miao Ou, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang, Ding Li
BACKGROUND: Telomeric repeat-containing RNA (TERRA) is a large non-coding RNA in mammalian cells, which forms an integral component of telomeric heterochromatin. TERRA can bind to an allosteric site of telomeric repeat factor 2 (TRF2), a key component of Shelterin that protect chromosome termini. Both TERRA and TRF2 have been recognized as promising new therapeutic targets for cancer treatment. METHODS: Our methods include FRET assay, SPR, CD, microscale thermophoresis (MST), enzyme-linked immunosorbent assay (ELISA), chromatin immunoprecipitation (ChIP), colony formation assays, Western blot, immunofluorescence, cell cycle arrest and apoptosis detection, and xCELLigence real-time cell analysis (RTCA)...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28943212/modification-of-fasciocutaneous-radial-forearm-free-flap-to-achieve-two-layer-closure-during-reconstruction-of-circumferential-hypopharyngeal-defects
#6
M Abu-Serriah, S Loughran
Circumferential defects of the hypopharynx are a reconstructive challenge. Various local, regional and free flaps have been described with each having advantages and disadvantages in terms of functional outcomes. The fasciocutaneous radial forearm free flap (RFFF) is one of the most common free flaps used for reconstructing circumferential hypopharyngeal defects. The skin paddle is pliable and reasonably matches the native hypopharyngeal wall. It is easy to raise, has predictable vascular anatomy and a long pedicle...
September 21, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28943104/fructose-1-6-diphosphate-prevents-alcohol-induced-liver-injury-through-inhibiting-oxidative-stress-and-promoting-alcohol-metabolism-in-mice
#7
Ling Li, Yifei Wu, Fangyuan Yin, Qin Feng, Xiaoliang Dong, Ruhui Zhang, Zhimin Yin, Lan Luo
Fructose 1, 6-diphosphate (FDP), a glycolytic intermediate,has been identified to possess antioxidant activities. Here we show the protective effect of FDP against alcohol-induced liver injury in mice and the underlying mechanisms. The in vivo experiments demonstrated that FDP, orally administered to mice, dose-dependently suppressed alcohol (50%, v/v, 12ml/kg)-induced increase of serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum triglyceride (TG) level and hepatic malondialdehyde (MDA) level...
September 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28942826/nitric-oxide-synthase-inhibitors-protect-against-brain-and-liver-damage-caused-by-acute-malathion-intoxication
#8
Omar M E Abdel-Salam, Eman R Youness, Nadia A Mohammed, Noha N Yassen, Yasser A Khadrawy, Safinaz Ebrahim El-Toukhy, Amany A Sleem
OBJECTIVE: To investigate the effect of N(G)-nitro-l-arginine methyl ester (l-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, and 7-nitroindazole (7-NI), a selective neuronal NOS inhibitor, on oxidative stress and tissue damage in brain and liver and on DNA damage of peripheral blood lymphocytes in malathion intoxicated rats. METHODS: Malathion (150 mg/kg) was given intraperitoneally (i.p.) along with l-NAME or 7-NI (10 or 20 mg/kg, i.p.) and rats were euthanized 4 h later...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942443/a-novel-role-of-sirt1-fgf-21-in-taurine-protection-against-cafeteria-diet-induced-steatohepatitis-in-rats
#9
Azza H Abd Elwahab, Basma K Ramadan, Mona F Schaalan, Amina M Tolba
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the alarmingly rising clinical problems in the 21st century with no effective drug treatment until now. Taurine is an essential amino acid in humans that proved efficacy as a non-pharmacological therapy in a plethora of diseases; however, its impact on NAFLD remains elusive. The aim of the current study is to evaluate the protective mechanism of taurine in experimental steatohepatitis induced by junk food given as cafeteria-diet (CAF-D) in male albino rats...
September 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28942082/elucidation-of-protective-efficacy-of-pentahydroxy-flavone-isolated-from-madhuca-indica-against-arsenite-induced-cardiomyopathy-role-of-nrf-2-ppar-%C3%AE-c-fos-and-c-jun
#10
Anwesha A Mukherjee, Amit D Kandhare, Subhash L Bodhankar
BACKGROUND: Madhuca indica J. F. Gmel. (Sapotaceae) is widely used ethnobotanically as anti-diabetic, antipyretic, hepatoprotective, anti-inflammatory and analgesic. It was shown to possess potent anti-apoptotic property. THE AIM OF THE STUDY: To evaluate the possible mechanism of action of isolated phytoconstituent from Madhuca indica Leaves methanolic extract (MI-ALC) on arsenic-induced cardiotoxicity in rats. MATERIALS AND METHODS: The 3,5,7,3',4'-Pentahydroxy flavone (QTN) was isolated and characterized by using HPTLC, (1)H NMR, and LC-MS from MI-ALC...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28941826/icp-drc-ms-analysis-of-serum-essential-and-toxic-element-levels-in-postmenopausal-prediabetic-women-in-relation-to-glycemic-control-markers
#11
Margarita G Skalnaya, Anatoly V Skalny, Eugeny P Serebryansky, Vasily V Yurasov, Anastasia A Skalnaya, Alexey A Tinkov
PURPOSE: Assessment of the influence of prediabetes on serum trace element and electrolyte levels in postmenopausal women. METHODS: A total of 80 prediabetic and 80 healthy postmenopausal women took part in the present study. Serum was analyzed for glucose, insulin, insulin resistance index (HOMA-IR), total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT). Glycated haemoglobin (HbA1c) levels were also assessed...
September 14, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28941695/antioxidant-and-hepatoprotective-effects-of-a-cerana-honey-against-acute-alcohol-induced-liver-damage-in-mice
#12
Haoan Zhao, Ni Cheng, Liangliang He, Guoxia Peng, Xiaofeng Xue, Liming Wu, Wei Cao
A. cerana honey, gathered from Apis cerana Fabricius (A. cerana), has not been fully studied. Samples of honey originating from six geographical regions (mainly in the Qinling Mountains of China) were investigated to determine their antioxidant and hepatoprotective effects against acute alcohol-induced liver damage. The results showed that A. cerana honeys from the Qinling Mountains had high total phenolic contents (345.1-502.1mgGAkg(-1)), ascorbic acid contents (153.8-368.4mgkg(-1)), and strong antioxidant activities in DPPH radical scavenging activity assays (87...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941653/in-vitro-and-in-vivo-study-of-the-application-of-volvox-spheres-to-co-culture-vehicles-in-liver-tissue-engineering
#13
Siou Han Chang, Han Hsiang Huang, Pei Leun Kang, Yu Chian Wu, Ming-Huang Chang, Shyh Ming Kuo
Volvox sphere is a biomimetic concept of a natural Volvox, wherein a large outer sphere contains smaller inner spheres, which can encapsulate cells and provide a double-layer three-dimensional environment for culturing cells. This study simultaneously encapsulated rat mesenchymal stem cells (MSCs) and AML12 hepatocytes in volvox spheres and extensively evaluated the effects of various culturing modes on cell functions and fates. The results showed that compared with a static flask culture, MSCs encapsulated in volvox spheres differentiated into hepatocyte-like cells with a 2-fold increase in albumin (ALB) expression and a 2...
September 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28941598/energy-matched-moderate-and-high-intensity-exercise-training-improves-nonalcoholic-fatty-liver-disease-risk-independent-of-changes-in-body-mass-or-abdominal-adiposity-a-randomized-trial
#14
Nathan C Winn, Liu Ying, R Scott Rector, Elizabeth J Parks, Jamal A Ibdah, Jill A Kanaley
BACKGROUND AND PURPOSE: Exercise training is commonly prescribed for individuals diagnosed with nonalcoholic fatty liver disease (NAFLD); however, consensus regarding the volume and intensity of exercise for optimal benefits is lacking. Thus, we determined whether high intensity interval exercise training (HIIT) produced greater reductions in intrahepatic lipid (IHL) content and NAFLD risk factors compared with energy-matched moderate intensity continuous exercise training (MICT) in obese adults with liver steatosis...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28941137/incidence-determinants-and-outcomes-of-pregnancy-associated-hepatitis-b-flares-a-regional-hospital-based-cohort-study
#15
Tatyana Kushner, Pamela A Shaw, Ankush Kalra, Lora Magaldi, Pooja Monpara, Gurneet Bedi, Karen Krok, Sierra Centkowski, Katherine Dalldorf, Julia D'souza, Dina Halegoua-De Marzio, David S Goldberg, Stacey Trooskin, Lisa D Levine, Sindhu K Srinivas, James D Lewis, Kimberly A Forde, Vincent Lo Re
BACKGROUND & AIMS: There is limited knowledge about hepatitis B virus (HBV) flare among pregnant women. We evaluated the incidence, determinants, and outcomes of HBV flare in a multicultural cohort of pregnant HBV-infected women in the United States. METHODS: We performed a retrospective cohort study of pregnant hepatitis B surface antigen-positive women cared for at hospital-based clinics of four medical centers in Southeastern Pennsylvania from 2006-2015. The main outcome was incident HBV flare (alanine aminotransferase [ALT] ≥2 times upper limit of normal) during pregnancy or within 6 months after delivery...
September 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28941136/comparison-of-surgical-outcomes-between-patients-with-unilateral-and-bilateral-chronic-rhinosinusitis
#16
Daniel M Beswick, Jess C Mace, Naweed I Chowdhury, Jeremiah A Alt, Peter H Hwang, Adam S DeConde, Timothy L Smith
BACKGROUND: Although the majority of patients with chronic rhinosinusitis without nasal polyposis (CRSsNP) suffer from bilateral disease, a subset suffer from unilateral disease. Currently, outcomes following endoscopic sinus surgery (ESS) for medically recalcitrant CRS are inferred from outcomes for patients with bilateral disease. This study compares outcomes of ESS between patients with unilateral and bilateral disease. METHODS: Patients with CRSsNP who failed appropriate medical therapy and elected ESS were enrolled between 2011 and 2015...
September 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28940824/clinical-implications-of-controlled-attenuation-parameter-in-a-health-check-up-cohort
#17
Min-Sun Kwak, Goh Eun Chung, Jong In Yang, Jeong Yoon Yim, Su Jin Chung, Se Young Jung, Joo Sung Kim
BACKGROUND & AIMS: Evaluation of the controlled attenuation parameter (CAP) is a promising noninvasive method for assessing hepatic steatosis. Despite the increasing reliability of the CAP for assessing steatosis in subjects with chronic liver disease, few studies have evaluated the CAP in asymptomatic subjects without overt liver disease. Therefore, we aimed to evaluate the usefulness of the CAP for a health check-up population. METHODS: We enrolled subjects who underwent abdominal ultrasonography (US), FibroScan (Echosens, France) and blood sampling during medical health check-ups...
September 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940714/tear-drop-free-anterolateral-thigh-flap-a-versatile-design-for-lower-limb-reconstruction-after-trauma
#18
Sergio Razzano, Samir Ramadan, Andrea Figus, Richard M Haywood
BACKGROUND: In lower limb reconstruction the cosmetic outcome is influenced by the contouring of the flap at the recipient site as well as by the donor site closure. It is also important to minimise compression of the flap pedicle. We discuss the outcomes of a versatile ALT flap design that allows freedom in skin paddle tailoring without elongating the scar, reduction of the tension over the pedicle and improved cosmetic results of both donor and recipient sites. METHODS: Between January 2009 and October 2015, 27 patients underwent reconstruction using tear drop ALTs...
September 21, 2017: Microsurgery
https://www.readbyqxmd.com/read/28940313/n-glycolylneuraminic-acid-knockout-reduces-erythrocyte-sequestration-and-thromboxane-elaboration-in-an-ex-vivo-pig-to-human-xenoperfusion-model
#19
Arielle Cimeno, Wessam Hassanein, Beth M French, Jessica M Powell, Lars Burdorf, Olga Goloubeva, Xiangfei Cheng, Dawn M Parsell, Jagdeece Ramsoondar, Kasinath Kuravi, Todd Vaught, Mehmet C Uluer, Emily Redding, Natalie O'Neill, Christopher Laird, Alena Hershfeld, Ivan Tatarov, Kathryn Thomas, David Ayares, Agnes M Azimzadeh, Richard N Pierson, Rolf N Barth, John C LaMattina
BACKGROUND: Wild-type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood cells causing sequestration, in addition to antibody-mediated xenograft injury. One such carbohydrate is N-glycolylneuraminic acid (Neu5Gc), a sialic acid molecule synthesized in pigs but not in humans. Here, we evaluate livers with and without Neu5Gc in an ex vivo liver xeno perfusion model...
September 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28939470/market-entry-power-pharmacokinetics-what-makes-a-successful-drug-innovation
#20
Susanne Alt, Axel Helmstädter
Depending on the timing of market entry, radical innovations can be distinguished from incremental innovations. Whereas a radical innovation typically is the first available derivative of a drug class, incremental innovations are launched later and show a certain benefit compared with the radical innovation. Here, we use historical market data relating to pharmacokinetic (PK), pharmacodynamic (PD), and other drug-related properties to investigate which derivatives within certain drug classes have been most successful on the market...
September 20, 2017: Drug Discovery Today
keyword
keyword
12459
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"