Asako Inohaya, Yoshitsugu Chigusa, Masahito Takakura, Shingo Io, Min-A Kim, Yu Matsuzaka, Eriko Yasuda, Yusuke Ueda, Yosuke Kawamura, Shiro Takamatsu, Haruta Mogami, Yasuhiro Takashima, Masaki Mandai, Eiji Kondoh
The intervillous space of human placenta is filled with maternal blood, and villous trophoblasts are constantly exposed to the shear stress generated by maternal blood pressure and flow throughout the entire gestation period. However, the effects of shear stress on villous trophoblasts and their biological significance remain unknown. Here, using our recently established naïve human pluripotent stem cells-derived cytotrophoblast stem cells (nCTs) and a device that can apply arbitrary shear stress to cells, we investigated the impact of shear stress on early-stage trophoblasts...
October 31, 2023: Biology of Reproduction