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A Matveeva, L Kovalevska, I Kholodnyuk, T Ivanivskaya, E Kashuba
AIM: To study the status of the tumor growth factor beta (TGFB) pathway in chronic lymphocytic leukemia (CLL) cells and to uncover molecular details underlying CLL cell genesis. OBJECTS AND METHODS: The study was conducted on peripheral blood samples of patients with CLL using the following methods: RNA isolation, analysis of expression of transcription factors using RT2 profiler assay, bioinformatics analysis of publicly available data bases on expression. RESULTS: We have shown that the TGFB - SMAD canonical pathway is not active in CLL cells...
December 2017: Experimental Oncology
Elisabeth Pietilä Holmner, Britt-Marie Stålnacke, Paul Enthoven, Gunilla Stenberg
OBJECTIVE: To explore patient experiences of participating in multimodal pain rehabilitation in primary care. SUBJECTS: Twelve former patients (7 women and 5 men) in multimodal rehabilitation in primary care were interviewed about their experiences of multimodal rehabilitation. METHODS: The interviews were analysed using qualitative content analysis. RESULTS: Analysis resulted in 4 categories: (i) from discredited towards obtaining redress; (ii) from uncertainty towards knowledge; (iii) from loneliness towards togetherness; and (iv) "acceptance of pain": an ongoing process...
October 27, 2017: Journal of Rehabilitation Medicine
Dragana Gabrić, Sven Seiwerth, Anja Baraba, Vanja Vučićević, Boras
OBJECTIVE: Ishemic bone disease has multifactorial etiologies. Cronic dental infections should be eliminated to prevent osteonecrosis of the jaw. CASE REPORT: We report an unusual case of osteonecrosis due to the pulpal-peridontal syndrome and subsequent pulp necrosis. A case of 38 year old woman who presented with exposed bone, 8 mm in diameter, in the lingual area of the right lower third molar. The patient was otherwise healthy and was not taking any medications...
March 2017: Acta Stomatologica Croatica
Antonio Martinez-Lopez, Gonzalo Blasco-Morente, Israel Perez-Lopez, Salvador Arias-Santiago
No abstract text is available yet for this article.
March 3, 2017: Medicina Clínica
Mehdi Hedayati, Zahra Nozhat, Masoomeh Hannani
Thyroid cancer, the most common endocrine neoplasia, consists of four main types of carcinomas: papillary, follicular, and anaplastic, all with thyroid follicular origin, and medullary thyroid cancer (MTC) related to para-follicular cells. Cronic diseases such as diverse cancers may be associated with cachexia, especially at advanced stage. Cancer-induced cachexia is associated with diminished quality of life, functional performance, reduced response to antitumor therapy, and increased morbidity and mortality...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
D Costantino, C Guaraldi, M Costantino, V E Bounous
Postpartum pain is a frequent condition that negatively affects women's quality of life, interferring with everyday life. Analgesic drugs and surgery are often contraindicated in pregnancy and during breast feeding. This review of the literature aims to evaluate the rational of the association of lipoic acid and omega-3 employ in the management of postpartum pain. Lipoic acid is a cofactor essential in mitochondrial metabolism with antioxidant and anti-inflammatory activity. Lipoic acid has been shown to be effective in neuropatic pain treatment in patients with sciatica, carpal tunnel syndrome and diabetic neuropathy...
October 2015: Minerva Ginecologica
I Birsan
AIM: This study was to determine the markers representative of pathogenic periodontal microflora [Prevotella intermedia (P.i), Tannerella forsythia (T.f) [Bacteroides forsythus], Treponema denticola (T.d), Actinobacillus actinomycetemcomitans (A.a), Porphyromonas gingivalis (P.g)] in the dental plaque of adolescents with various degrees of severity of periodontium inflammation. METHODS: Forty-patients aged 15-16 years of age were examined using PMA, CPI and Green-Vermillion indices (Müller 2001)...
February 2015: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Sandra Alexandre Lozano, Carme Marquilles Bonet, Joan-Enric Torra I Bou, Marta Llobet Burgués
The cronicity of a wound can be produced by the alteration of several factors. One of the agents that can produce a delay in the wound healing process is malnutrition. According with the evidence, nutrition is an important factor in chronic wound prevention and treatment. The prevalence of low extremity wounds increases in population aged 65 or more. As we became older, malnutrition risk is more relevant due to physiological changes related to ageing. We describe a clinical case of a torpid venous leg ulcer in an elder patient centering on nutrition assessment and management...
May 2014: Revista de Enfermería
Giuseppe Fiorentino, Anna Annunziata, Rosa Cauteruccio, Raffaele Cobuccio, Mario Caputi
SESSION TITLE: Pediatric PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: to evaluate the feasibility of low-level BCPAP in pediatric patients affected by cronic respiratory failure secondary to congenital heart disease (univentricular heart) with tracheostomy tube. METHODS: 8 pediatric patients, aged between 3 and 20 months with congenital heart disease corrected surgically. After tracheostomy, it was not possible to wean according to classical procedures of weaning...
March 1, 2014: Chest
Morana Bilić, Vlatko Micković, Zoran Loncar
The aim of this study was to analyze the association between chronic low back pain (LBP) in chronic post-traumatic stress disorder (PTSD) with quality and intensity of pain experience. A total of 406 war veterans from 1991-1995 war in Croatia participated in this study. They were divided into four groups, according to psychiatric interview, psychometric testing and the presence of LBP verified by the imaging of lumbar area, into: (i) war veterans suffering from PTSD and LBP (N = 102), (ii) war veterans suffering from PTSD only (N = 108), (iii) war veterans suffering from LBP only (N = 99) and (iv) healthy controls (N = 97)...
December 2013: Collegium Antropologicum
S V Got'e, M Iu Shagidulin, N A Onishchenko, M E Krasheninnikov, I M Il'inskiĭ, N P Mozheĭko, A V Liundup, E A Volkova, K I Petrakov, P V Avramov, N V Perova, V I Sevast'ianov
On an experimental model of chronic fibrotic liver damage (male rats Wistar (n-60), damage of CCl4, the duration of the experiment 90 days) it was studied the effectiveness of cell therapy for the correction of chronic liver failure. These rats were divided into 3 experimental groups: in the Ist-group (control, n=10) isotonic saline (650 mkl.) was injected; in the IInd-group (n=20) suspension of liver cells was applicated in a dose 8 - l0 x 10(6) cells; in the IIIrd-group (n=30) suspension of liver cells and bone marrow cells (mesenchymal stromal cells) in ratio 5:1 were used as cell associates on microparticles intjectable heterogeneous biopolymer hydrogel "SpheroGEL" (cell-engineering design) in common dose 8 - l0 x 10(6) It was ascertained that in the 2nd and in the 3rd groups the accelerated normalization of disturbed liver functional indices (ALT, AST, ALP) took place - to 30 days, but in the control group only to 90 days...
2013: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Radu Badea, Liliana Chiorean, Dana Damian, Geza Molnar, Ofelia Anton
Mesenteric panniculitis represents a cronic inflammation of the adipose tissue of the mesentery which can present sometimes with the imagistic aspect of one or multiples pseudotumors. We present the case of female patient in which mesenteric panniculitis was found accidentally during a routine abdominal ultrasound examination leading to differential diagnostics problems. Color Doppler and contrast enhancement ultrasonography were helpful for diagnosis evidencing a benign circulatory signal.
September 2013: Medical Ultrasonography
Jinhuo Luo
In this paper, we derive and analyze a mathematical model for the interactions between phytoplankton and zooplankton in a periodic environment, in which the growth rate and the intrinsic carrying-capacity of phytoplankton are changing with respect to time and nutrient concentration. A threshold value: "Predator's average growth rate" is introduced and it is proved that the phytoplankton-zooplankton ecosystem is permanent (both populations survive cronically) and possesses a periodic solution if and only if the value is positive...
October 2013: Mathematical Biosciences
F Floccari, A Granata, R Rivera, F Marrocco, A Santoboni, M Malaguti, S Andrulli, L Di Lullo
TAPSE measurement during echocardiography is a well known measure of right heart systo-diastolic function. Low TAPSE means reduced cranio-caudal excursion of tricuspidal annulus, sign of both reduced ejection fraction and reduced distensibility of right ventricle. It is a good prognostic index for cardiac mortality risk in CHF patients, adding significant prognostic information to NYHA stadiation. Nephrologists do not always fully aware of right ventricular function in their patients affected by chronic renal failure (CRF), even if this datum is probably crucial in vascular access policy...
December 2012: Journal of Ultrasound
Özlem Özen Ekmekci, Meryem Tahmaz, Semih Altıparmak, Gülnar Gülaçtı, A Kadir Ergen, A Baki Kumbasar, Sezer Sepetcioğlu, Y Ali Öner
Strongyloides stercoralis is an intestinal nematode of humans that infects tens of millions of people worldwide. It is a rarely reported parasitic infestation in Turkey. Disseminated strongyloidiosis may develop in patients with immunodeficiencies. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Glucocorticoid treatment is one of the conditions most specifically associated with triggering hyperinfection, but cases have been reported in association with hematologic malignancy, malnutrition, and AIDS...
2013: Türkiye Parazitolojii Dergisi
Luis Eduardo Hernández-Ibarra, Francisco J Mercado-Martínez
OBJECTIVE: To examine health care provided to chronically ill people in the Popular Health Insurance (Seguro Popular) from the perspective of patients and health professionals. MATERIALS AND METHODS: A qualitative study was carried out in Guadalajara, Mexico. 40 chronically ill people, and 14 health professionals of primary health centers participated in the study. Information was gathered using semi-structured interviews; critical discourse analysis was carried out...
April 2013: Salud Pública de México
Fernando Arévalo, Violeta Aragón, Pedro Montes, Teresa Pérez Narrea, Eduardo Monge
OBJECTIVES: 1) To determine the prevalence of increased number of eosinophils in colonic mucosa of patients with lymphocytic colitis (LC). 2) To determine the coexistence of eosinophilic colitis (EC) in patients with lymphocytic colitis. MATERIALS AND METHODS: slides of adult patients with cronic diarrhea with diagnosis of LC were reviewed between October 2009 and March 2012. The number of eosinophils was quantified. RESULTS: Sixty eight patients with LC were included...
January 2013: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Dario DiFrancesco
Many diverse data support a role of the funny current (If) in pacemaking and heart rate control. Among them, clinically relevant applications have special impact, since they translate the concept of funny channel-based pacemaking into practical developments of potential therapeutic value. For example, the If role in pacemaking is the basis for a pharmacological approach to heart rate control. Ivabradine, a specific f-channel blocker acting as a 'pure heart rate reducing' agent, is used today as a therapeutic tool in chronic stable angina and heart failure...
September 1, 2013: Journal of Physiology
A Gambelunghe, C Antognelli, N Murgia, M dell'Omo, V N Talesa, G Muzi
Crystalline silica (Min-U-Sil-5) induces oxidative stress in human bronchial epithelial cells (BEAS-2B), through the intracellular accumulation of ROS that cause oxidative damage leading to the degradation of extracellular matrix (ECM) proteins and to the loss of cell adhesion molecules inducing apoptosis and genotoxic damage. This paper briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which the cronic and cumulative exposure to crystalline silica can induce cellular damage that promotes changes in extracellular matrix and in apoptosis gene expression...
July 2011: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Sem Decani, Veronica Federighi, Elisa Baruzzi, Andrea Sardella, Giovanni Lodi
Topical corticosteroids are considered first-line therapy in patients with chronic inflammatory oral mucosal diseases; among them, clobetasol propionate is one of the most widely used in oral medicine. Under physiological conditions, the transmucosal application is characterized by a significantly greater absorption than the skin application. Contrary to many publications about the side effects of topical corticosteroids in dermatology, few studies have investigated the systemic effects due to local application of these drugs on oral mucosa...
December 2014: Journal of Dermatological Treatment
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