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https://www.readbyqxmd.com/read/28549143/bile-acids-and-tryptophan-metabolism-are-novel-pathways-involved-in-metabolic-abnormalities-in-bpa-exposed-pregnant-mice-and-male-offspring
#1
Martha Susiarjo, Frances Xin, Martha Stefaniak, Clementina Mesaros, Rebecca A Simmons, Marisa S Bartolomei
Increasing evidence has demonstrated that exposure to endocrine disrupting chemicals (EDCs) impacts maternal and fetal health, but the underlying mechanisms are still unclear. We have previously shown that dietary exposure to 10 µg/kg bw/day and 10 mg/kg bw/day bisphenol A (BPA) during pregnancy induced metabolic abnormalities in F1 male offspring and gestational glucose intolerance in F0 pregnant mice. The aim of this study is to elucidate the underlying etiologies of BPA exposure-induced metabolic disease by analyzing male fetal liver metabolome...
May 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28548927/the-impact-of-delayed-commencement-of-adjuvant-chemotherapy-eight-or-more-weeks-on-survival-in-stage-ii-and-iii-colon-cancer-a-national-population-based-cohort-study
#2
Young Wan Kim, Eun Hee Choi, Bo Ra Kim, Woo-Ah Ko, Yeong-Mee Do, Ik Yong Kim
BACKGROUND: To examine the impact of chemotherapy delay on survival in patients with stage II or III colon cancer and the factors associated with the delay (≥8 weeks) of adjuvant chemotherapy. METHODS: Patients undergoing curative resection and adjuvant chemotherapy in a national population-based cohort were included. RESULTS: Among 5355 patients, 154 (2.9%) received chemotherapy more than 8 weeks after surgery. Based on a multivariate analysis, the risk factors associated with chemotherapy delay ≥8 weeks were older age [65 to 74 years (hazard ratio [HR]=1...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548846/ambient-size-distributions-and-lung-deposition-of-aerosol-dithiothreitol-measured-oxidative-potential-a-contrast-between-soluble-and-insoluble-particles
#3
Ting Fang, Linghan Zeng, Dong Gao, Vishal Verma, Aleksandr B Stefaniak, Rodney J Weber
Ambient particulate matter (PM) may upset redox homeostasis leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OP^DTT (dithiothreitol assay, measure of oxidative potential per air volume) are reported for a road-side and urban site. The average water-insoluble fractions were 23% and 51%, and 37% and 39% for fine and coarse mode at the road-side and urban site, respectively, measured during different periods. Water-soluble OP^DTT was unimodal peaked near 1-2...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548613/recommendations-for-research-on-suicide-loss-a-commentary
#4
Robert A Neimeyer, Julie Cerel, Myfanwy Maple
As detailed in the lead article in this Special Issue, the Survivors of Suicide Loss Task Force of the National Action Alliance for Suicide Prevention in the United States has recently worked to formulate national guidelines to mitigate the harmful after-effects of suicide in social and family systems. In the present article, we elaborate on one of four strategic directions addressed by the Task Force, namely the development of goals and objectives for surveillance, research and evaluation of the impact of suicide loss...
May 26, 2017: Death Studies
https://www.readbyqxmd.com/read/28548494/resource-footprints-are-good-proxies-of-environmental-damage
#5
Zoran J N Steinmann, Aafke M Schipper, Mara Hauck, Stefan Giljum, Gregor Wernet, Mark A J Huijbregts
Environmental footprints are increasingly used to quantify and compare environmental impacts of for example products, technologies, households, or nations. This has resulted in a multitude of footprint indicators, ranging from relatively simple measures of resource use (water, energy, materials) to integrated measures of eventual damage (for example, extinction of species). Yet, the possible redundancies among these different footprints have not yet been quantified. This paper analyzes the relationships between two comprehensive damage footprints and four resource footprints associated with 976 products...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548289/effects-of-food-borne-nanomaterials-on-gastrointestinal-tissues-and-microbiota
#6
REVIEW
Hans Bouwmeester, Meike van der Zande, Mark A Jepson
Ingestion of engineered nanomaterials is inevitable due to their addition to food and prevalence in food packaging and domestic products such as toothpaste and sun cream. In the absence of robust dosimetry and particokinetic data, it is currently challenging to accurately assess the potential toxicity of food-borne nanomaterials. Herein, we review current understanding of gastrointestinal uptake mechanisms, consider some data on the potential for toxicity of the most commonly encountered classes of food-borne nanomaterials (including TiO2 , SiO2, ZnO, and Ag nanoparticles), and discuss the potential impact of the luminal environment on nanoparticle properties and toxicity...
May 26, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28548239/impact-of-barium-enema-on-acute-diverticulitis-recurrence-a-retrospective-cohort-study-of-349-patients
#7
Francisco J Medina-Fernández, Lidia Rodríguez-Ortiz, Dimas J Garcilazo-Arismendi, Elena Navarro-Rodríguez, Eva M Torres-Tordera, César A Díaz-López, Javier Briceño
AIM: Acute diverticulitis is becoming a health concern in western countries as its incidence is increasing. Currently, one of the accepted theories on possible causes of diverticular perforation is the impactation of faecal residuals into some diverticula. Our aim was to evaluate whether barium impactation might have a negative effect by promoting diverticular inflammation/rupture and thereby acute diverticulitis recurrence. METHODS: A retrospective cohort study (January 2005/December 2015) was conducted at the Reina Sofia University Hospital of Cordoba (Spain)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28547926/transdisciplinarity-in-health-care-a-concept-analysis
#8
Vanessa Van Bewer
AIM: To analyze the concept of transdisciplinarity and provide an enhanced definition of transdisciplinarity in health care. BACKGROUND: The term transdisciplinarity is increasingly prevalent in health care research and has been identified as important to improving the effectiveness and efficiency in health care. However, the term continues to be misappropriated and poorly understood by researchers and clinicians alike which hinders its potential use and impact...
May 26, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28547806/examining-the-psychological-and-social-impact-of-relative-age-in-primary-school-children-a-cross-sectional-survey
#9
A Price, K Allen, O C Ukoumunne, R Hayes, T Ford
BACKGROUND: A number of studies demonstrate that children who are younger within their school year have poorer academic attainment and are more likely to have special educational needs. Few, however, have considered the impact relative age may have on child mental health, behaviour and happiness in school. METHODS: This paper utilized data from the Supporting Teachers and Children in Schools study (2075 pupils aged 5 to 9 years from 80 primary schools) to explore the relationship among relative age, behaviour and happiness in school...
May 25, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28547746/the-support-needs-of-parents-having-a-child-with-a-chronic-kidney-disease-a-focus-group-study
#10
W W Geense, B G I van Gaal, J L Knoll, E A M Cornelissen, T van Achterberg
BACKGROUND: Parents of children with a chronic kidney disease (CKD) have a crucial role in the management of their child's disease. The burden on parents is high: they are often exhausted, depressed and experience high levels of stress and a low quality of life, which could have a negative impact on their child's health outcomes. Support aiming at preventing and reducing parental stress is essential. Therefore, it is necessary to have insight in the problems and support needs among these parents...
May 25, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28547656/influence-of-clinical-societal-and-treatment-variables-on-racial-differences-in-er-pr-breast-cancer-survival
#11
M E Roseland, K Schwartz, J J Ruterbusch, L Lamerato, R Krajenta, J Booza, Michael S Simon
BACKGROUND: African American (AA) women with breast cancer have persistently higher mortality compared to whites. We evaluated racial disparities in mortality among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer. METHODS: The study population included 542 women (45% AA) diagnosed with ER/PR-negative Stage I through III breast cancer treated at the Henry Ford Health System (HFHS) between 1996 and 2005. Linked datasets from HFHS, Metropolitan Detroit Cancer Surveillance System, and the U...
May 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28547375/the-effects-of-ozone-on-human-health
#12
Daniela Nuvolone, Davide Petri, Fabio Voller
Ozone is a highly reactive, oxidative gas associated with adverse health outcome, including mortality and morbidity. Data from monitoring sites worldwide show levels of ozone often exceeding EU legislation threshold and the more restrictive WHO guidelines for the protection of human health. Well-established evidence has been produced for short-term effects, especially on respiratory and cardiovascular systems, associated to ozone exposure. Less conclusive is the evidence for long-term effects, reporting suggestive associations with respiratory mortality, new-onset asthma in children and increased respiratory symptom effects in asthmatics...
May 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28547179/telomere-length-measurement-by-qpcr-in-birds-is-affected-by-storage-method-of-blood-samples
#13
Sophie Reichert, Hannah Froy, Winnie Boner, Theresa M Burg, Francis Daunt, Robert Gillespie, Kate Griffiths, Sue Lewis, Richard A Phillips, Dan H Nussey, Pat Monaghan
Given the potential role of telomeres as biomarkers of individual health and ageing, there is an increasing interest in studying telomere dynamics in a wider range of taxa in the fields of ecology and evolutionary biology. Measuring telomere length across the lifespan in wild animal systems is essential for testing these hypotheses, and may be aided by archived blood samples collected as part of longitudinal field studies. However, sample collection, storage, and DNA extraction methods may influence telomere length measurement, and it may, therefore, be difficult to balance consistency in sampling protocol with making the most of available samples...
May 25, 2017: Oecologia
https://www.readbyqxmd.com/read/28546971/the-impact-of-the-customer-relationship-management-on-organizational-productivity-customer-trust-and-satisfaction-by-using-the-structural-equation-model-a-study-in-the-iranian-hospitals
#14
Maryam Yaghoubi, Hamed Asgari, Marzieh Javadi
CONTEXT: One of the challenges in the fiercely competitive space of health organizations is responding to customers and building trust and satisfaction in them in the shortest time, with best quality and highest productivity. Hence the aim of this study is to survey the impact of customer relationship management (CRM) on organizational productivity, customer loyalty, satisfaction and trust in selected hospitals of Isfahan (in Iran). MATERIALS AND METHODS: This study is a correlation descriptive research...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546970/the-impact-of-mother-s-literacy-on-child-dental-caries-individual-data-or-aggregate-data-analysis
#15
Ali-Akbar Haghdoost, Hossein Hessari, Mohammad Reza Baneshi, Maryam Rad, Arash Shahravan
INTRODUCTION: To evaluate the impact of mother's literacy on child dental caries based on a national oral health survey in Iran and to investigate the possibility of ecological fallacy in aggregate data analysis. MATERIALS AND METHODS: Existing data were from second national oral health survey that was carried out in 2004, which including 8725 6 years old participants. The association of mother's literacy with caries occurrence (DMF (Decayed, Missing, Filling) total score >0) of her child was assessed using individual data by logistic regression model...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546959/an-evaluation-of-oral-health-related-quality-of-life-in-orthodontic-patients-treated-with-fixed-and-twin-blocks-appliances
#16
Emad Em Alzoubi, Racha Hariri, Kevin Mulligan, Nikolai Attard
OBJECTIVE: To study the impact of orthodontic treatment on the quality of life in two patient groups, one treated with the twin block appliance and the other with fixed appliances. MATERIALS AND METHODS: Ninety-eight patients, aged between 10 and 16 years, were recruited in the fixed (20 males and 29 females) or functional (29 males and 20 females) treatment groups. The oral health-related quality of life (OHRQoL) was measured before treatment and followed up at the end of the treatment...
April 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/28546772/the-impact-of-socioeconomic-status-and-multimorbidity-on-mortality-a-population-based-cohort-study
#17
Nikoline Lund Jensen, Henrik Søndergaard Pedersen, Mogens Vestergaard, Stewart W Mercer, Charlotte Glümer, Anders Prior
OBJECTIVE: Multimorbidity (MM) is more prevalent among people of lower socioeconomic status (SES), and both MM and SES are associated with higher mortality rates. However, little is known about the relationship between SES, MM, and mortality. This study investigates the association between educational level and mortality, and to what extent MM modifies this association. METHODS: We followed 239,547 individuals invited to participate in the Danish National Health Survey 2010 (mean follow-up time: 3...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28546754/patient-perceived-health-related-quality-of-life-before-and-after-laparoscopic-aortobifemoral-bypass
#18
Syed Sh Kazmi, Anne H Krog, Simen T Berge, Jon O Sundhagen, Mehdi Sahba, Ragnhild S Falk
BACKGROUND: In patients operated with laparoscopic aortobifemoral bypass (LABFB) for atherosclerotic obstruction in aortoiliac segment, the main focus of the reports published during the last two decades has been morbidity and mortality. The primary objective of this study was to examine the health-related quality of life (HRQL) in these patients before and after LABFB. PATIENTS AND METHODS: Fifty consecutive patients (27 females) with Trans-Atlantic Inter-Society Consensus II, type D lesions were prospectively included...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28546741/sj%C3%A3-gren-s-syndrome-is-associated-with-negatively-variable-impacts-on-domains-of-health-related-quality-of-life-evidence-from-short-form-36-questionnaire-and-a-meta-analysis
#19
REVIEW
Qiuxiang Zhang, Xulin Wang, Haoyang Chen, Biyu Shen
PURPOSE: The purpose of this article was to systematically review the literature to identify the impact of primary Sjögren's syndrome (pSS) on specific health-related quality of life (HRQoL) domains. METHODS: A meta-analysis was performed, and the related articles were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine, and Web of Science databases and in reference lists of articles and systematic reviews...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28546735/nonparametric-regression-method-for-broad-sense-agreement
#20
Akm Fazlur Rahman, Limin Peng, Amita Manatunga, Ying Guo
Characterizing the correspondence between an ordinal measurement and a continuous measurement is often of interest in mental health studies. To this end, Peng, Li, Guo, and Manatunga (2011) introduced the concept of broad sense agreement (BSA) and developed nonparametric estimation and inference for a BSA measure. In this work, we propose a non-parametric regression framework for BSA, which provides a robust tool to further investigate population heterogeneity in BSA. We develop inferential procedures including regression function estimation and hypothesis testing...
2017: Journal of Nonparametric Statistics
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