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https://www.readbyqxmd.com/read/28240008/role-of-plasticity-region-genes-and-cage-gene-of-cagpai-of-helicobacter-pylori-in-development-of-gastrointestinal-gi-diseases
#1
Shokufe GholizadeTobnagh, Seyedeh Zahra Bakhti, Saeid Latifi Navid, Saber Zahri, Fatemeh Sadat Bakhti
Background: Helicobacter pylori is a Gram-negative, micro aerophilic bacterium in the human stomach that is associated with the development of gastrointestinal ailments such as peptic ulcer (PU) and gastric cancer (GC). In the present study, plasticity region genes (jhp0940, jhp0945 and jhp0947) and and cagE gene of cagPAI were assessed independently and in combination for their ability to predict clinical consequences. Materials and Methods: A total of 211 strains which were isolated from patients with different gastrointestinal diseases (114 with non-atrophic gastritis, 59 with PU, and 38 with GC) were genotyped by PCR and sequencing...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240007/delineation-of-margins-for-the-planning-target-volume-ptv-for-image-guided-radiotherapy-igrt-of-gastric-cancer-based-on-intrafraction-motion
#2
Paulina Leszczyńska, Wojciech Leszczyński, Jerzy Wydmański, Dębiec Kinga, Agnieszka Namysł Kaletka, Andrzej Tukiendorf, Leszek Hawrylewicz
Background: Application of the image-guided radiotherapy (IGRT) system for gastric cancer involving daily verification of patient positioning on the treatment machine allows minimisation of geometrical errors as a consequence of intra- and inter-fraction motion. The purpose of this study was to define the intrafraction motion in gastric cancer patients during a treatment session based on the IGRT system and designation of margins around the clinical target volume CTV (internal target volume ITV) necessary to delineate the planning target volume (PTV)...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240005/surgery-for-diverticulitis-in-the-21st-century-recent-evidence
#3
Arden M Morris, Cindy Kin
Sigmoid diverticulitis is an increasingly common disease in Western countries. As technology has led to increased knowledge about the disease and options for treatment, management strategies have become less certain. In previous years, the rationale for early elective surgery was largely preventive, due to concern that diverticulitis recurrence would result in increased risk of sepsis or the need for a colostomy. New technology has enabled diagnosis, through computed tomography scans, predictive information through clinical and administrative databases, and less invasive treatment options, through laparoscopic techniques...
February 24, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28239999/glioblastoma-multiforme-a-review-of-its-epidemiology-and-pathogenesis-through-clinical-presentation-and-treatment
#4
Farina Hanif, Kanza Muzaffar, Kahkashan Perveen, Saima M Malhi, Shabana U Simjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. Despite advances in treatment modalities it remains largely incurable. The objective of our review is to provide a holistic picture of GBM epidemiology, etiology, pathogenesis, clinical findings and treatment. A literature search was conducted for GBM at PubMed and Google Scholar, with relevant key words like glioblastoma multiforme, pathogenesis, signs and symptoms, treatment etc., and papers published until 2015 were reviewed...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239996/re-presentations-and-recurrent-events-following-initial-management-of-the-acute-paediatric-scrotum-a-5-year-review
#5
Shareena Lala, Neil Price, Vipul Upadhyay
BACKGROUND: Previous reviews report relatively low rates of post-operative complications for acute scrotal exploration. The aim of this study was to evaluate the re-presentation to hospital in boys with previous acute scrotal pathology, reviewing contralateral symptoms, post-operative complications, testicular torsion following fixation and failure of conservative management of testicular appendage (TA) torsion. METHODS: All boys under 16 years presenting to our unit with an acute scrotum from January 2008 to December 2012 (5-year period) were identified...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28239984/cost-effectiveness-of-extended-release-naltrexone-to-prevent-relapse-among-criminal-justice-involved-persons-with-a-history-of-opioid-use-disorder
#6
Sean M Murphy, Daniel Polsky, Joshua D Lee, Peter D Friedmann, Timothy W Kinlock, Edward V Nunes, Richard J Bonnie, Michael Gordon, Donna T Chen, Tamara Y Boney, Charles P O'Brien
BACKGROUND/AIMS: Criminal-justice-involved persons are highly susceptible to opioid relapse and overdose-related deaths. In a recent randomized trial, we demonstrated the effectiveness of extended release naltrexone (XR-NTX; Vivitrol®) in preventing opioid relapse among criminal-justice-involved U.S. adults with a history of opioid use disorder. The cost of XR-NTX may be a significant barrier to adoption. Thus, it is important to account for improved quality of life, and downstream cost-offsets...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28239979/beyond-sodium-phosphate-and-potassium-potential-dietary-interventions-in-kidney-disease
#7
EDITORIAL
Jaimon T Kelly, Megan Rossi, David W Johnson, Katrina L Campbell
People with kidney disease are advised to restrict individual nutrients, such as sodium, potassium, and phosphate, in line with current best practice guidelines. However, there is limited evidence to support the efficacy of single nutrient strategies, and compliance remains a challenge for clinicians to overcome. Many factors contribute to poor compliance with dietary prescriptions, including conflicting priorities for single nutrient restriction, the arduous self-monitoring required, and the health-related knock-on effects resulting from targeting these nutrients in isolation...
February 26, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28239978/sleep-disordered-breathing-and-its-management-in-children-with-achondroplasia
#8
Rossana Tenconi, Sonia Khirani, Alessandro Amaddeo, Caroline Michot, Geneviève Baujat, Vincent Couloigner, Livio De Sanctis, Syril James, Michel Zerah, Valérie Cormier-Daire, Brigitte Fauroux
Sleep-disordered breathing is a common feature in children with achondroplasia. The aim of our study was to review the poly(somno)graphic (P(S)G) findings and consequent treatments in children with achondroplasia followed in the national reference center for skeletal dysplasia. A retrospective review of the clinical charts and P(S)G of 43 consecutive children (mean age 3.9 ± 3.5 years) with achondroplasia seen over a period of 2 years was performed. Twenty four (59%) children had obstructive sleep apnea (OSA)...
February 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28239974/simultaneous-monitoring-of-monoamines-amino-acids-nucleotides-and-neuropeptides-by-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-neurosecretion-in-bovine-chromaffin-cells
#9
Aneta Wojnicz, José Avendaño-Ortiz, Ricardo de Pascual, Lucía Ruiz-Pascual, Antonio G García, Ana Ruiz-Nuño
The primary functions of adrenal medullary chromaffin cells are the synthesis and storage in their chromaffin vesicles of the catecholamines noradrenaline (NA) and adrenaline (AD), and their subsequent release into the bloodstream by Ca(2+) -dependent exocytosis under conditions of fear or stress (fight or flight response). Several monoamines, nucleotides and opiates, such as leucine-enkephalin (LENK) and methionine-enkephalin (MENK), are also co-stored and co-released with the catecholamines. However, other neurotransmitters have not been studied in depth...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239961/in-pursuit-of-neurophenotypes-the-consequences-of-having-autism-and-a-big-brain
#10
David G Amaral, Deana Li, Lauren Libero, Marjorie Solomon, Judy Van de Water, Ann Mastergeorge, Letitia Naigles, Sally Rogers, Christine Wu Nordahl
A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD...
February 27, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28239956/spreading-of-thelazia-callipaeda-in-greece
#11
E Papadopoulos, A Komnenou, A Thomas, E Ioannidou, V Colella, D Otranto
Thelazia callipaeda (Spirurida, Thelaziidae), the so-called oriental eyeworm, has been increasingly reported as an agent of infection in animals and humans from many European countries. Clinical signs range from subclinical to moderate or severe ocular disorders (e.g., epiphora, photophobia, conjunctivitis, keratitis, ulcers). The disease has been also diagnosed in animals from countries of the Balkan area (e.g., Croatia, Bosnia and Herzegovina and Serbia), but only a single case of canine thelaziosis, presumably autochthonous, was reported in Northern Greece...
February 26, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28239953/depression-anxiety-and-health-related-quality-of-life-amongst-patients-who-are-starting-dialysis-treatment
#12
Ana Rebollo Rubio, José Miguel Morales Asencio, Ma Eugenia Pons Raventos
BACKGROUND: Chronic kidney disease (CKD) has a severe impact on patients' health-related quality of life (HRQL). The start of renal replacement therapy (RRT) significantly influences psychological, physical and social aspects of life. OBJECTIVES: To analyse the HRQL and psychological status (anxiety and depression) at the start of RRT. METHODS: We undertook an observational descriptive cross-sectional study. A total of 152 patients starting RRT were recruited for the study...
February 27, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28239951/the-technical-efficiency-of-oral-healthcare-provision-evaluating-role-substitution-in-national-health-service-dental-practices-in-england
#13
Harry Hill, Stephen Birch, Martin Tickle, Ruth McDonald, Paul Brocklehurst
OBJECTIVES: In many countries increasing use is being made of dental care professionals (DCPs) to provide aspects of clinical activity previously undertaken by dentists. This study evaluates the differences in practice efficiency associated with the utilisation of DCPs in the provision of General Dental Services in the National Health Service (NHS) in England. METHODS: One hundred twenty-one NHS practices completed a questionnaire and shared practice information held at the NHS Business Services Authority...
February 27, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28239948/burnout-depression-and-suicidal-ideation-in-dental-and-dental-hygiene-students
#14
George R Deeb, Sarah Braun, Caroline Carrico, Patricia Kinser, Daniel Laskin, Janina Golob Deeb
INTRODUCTION: The aim of this study was to assess the relationship between burnout, depressive symptoms and suicidal ideation in dental and dental hygiene students and to evaluate the influence of gender, programme type and year of study. SUBJECTS AND METHODS: Third- and fourth-year dental (DS) and first- and second-year hygiene students (DHS) completed the Patient Health Questionnaire (PHQ-9) and an abbreviated Maslach Burnout Inventory online as measures of depressive symptoms/suicidality and burnout, respectively...
February 27, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28239947/analysis-of-early-hepatic-artery-thrombosis-after-liver-transplantation
#15
Zhicheng Xue, Maogen Chen, Xuzhi Zhang, Guodong Wang, Xiaoshun He, Linwei Wu, Yi Ma
BACKGROUND: Hepatic artery thrombosis (HAT) is one of the deadliest complications after orthotopic liver transplantation (OLT). This study aimed to identify risk factors and summarize the experience of HAT management after OLT. METHODS: Clinical data of 407 adult patients who received OLT in our centres from July 2011 to December 2015 were retrospectively investigated. RESULTS: The incidence rate of early HAT was 2.0% (8/407). Recipient/donor weight ratio ≥1...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28239944/pancreatoduodenectomy-and-the-risk-of-complications-from-perioperative-fluid-administration
#16
Preetjote Gill, Terence C Chua, Yeqian Huang, Shreya Mehta, Anubhav Mittal, Anthony J Gill, Jaswinder S Samra
BACKGROUND: The dogma of administering sufficient intravenous fluids aggressively to avoid under-resuscitation has recently been challenged. Evidence suggests that excessive perioperative fluid administration may be associated with negative clinical outcomes in gastrointestinal surgery. This study examines the impact of fluid administration on perioperative outcomes in patients undergoing pancreatoduodenectomy (PD). METHODS: A retrospective analysis of 202 patients undergoing PD between January 2004 and August 2015 was performed...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28239942/extended-treatment-for-cigarette-smoking-cessation-a-randomized-control-trial
#17
Jennifer R Laude, Steffani R Bailey, Erin Crew, Ann Varady, Anna Lembke, Danielle McFall, Anna Jeon, Diana Killen, Joel D Killen, Sean P David
AIM: To test the potential benefit of extending cognitive-behavioral therapy (CBT) relative to not extending CBT on long-term abstinence from smoking. DESIGN: Two-group parallel randomised controlled trial. Patients were randomized to receive non-extended CBT (n = 111) or extended CBT (n = 112) following a 26-week open-label treatment. SETTING: Community clinic in the USA. PARTICIPANTS: 219 smokers (mean age: 43 years; mean cigarettes/day: 18)...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28239939/combining-the-gpr40-agonist-fasiglifam-with-sitagliptin-improves-glycemic-control-in-patients-with-type-2-diabetes-with-or-without-metformin-a-randomized-12-week-trial
#18
Xuejun V Peng, John F Marcinak, Marsha G Raanan, Charlie Cao
AIMS: To evaluate the efficacy and safety of fasiglifam, an orally active G protein-coupled receptor 40 agonist, in combination with the dipeptidyl peptidase-4 inhibitor sitagliptin, in patients with type 2 diabetes inadequately controlled with diet/exercise (± metformin). METHODS: In this randomized, double-blind, phase II study, 368 patients received once-daily placebo, sitagliptin 100 mg, fasiglifam 25 or 50 mg, or the combination of sitagliptin 100 mg plus fasiglifam 25 or 50 mg...
February 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28239935/isolation-and-characterization-of-an-atypical-siberian-sturgeon-herpesvirus-strain-in-russia-novel-north-american-acipenserid-herpesvirus-2-strain-in-europe
#19
A Doszpoly, I M Kalabekov, R Breyta, I S Shchelkunov
Siberian sturgeon herpesvirus (SbSHV) was isolated in Russia for the first time in 2006. Nine SbSHV isolates were recovered from different fish hatcheries producing the same cytopathic effect in cell cultures, the same clinical signs and mortality kinetics in virus-infected fish and the same virus neutralization pattern and shared identical nucleotide sequences. In 2011, a new isolate was recovered from juvenile sturgeon, which caused completely different cytopathic effect. That isolate was not readily neutralized by Siberian sturgeon hyperimmune antisera, and its DNA was not recognized by the routine PCR developed for SbSHV detection...
February 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28239930/secondary-cutaneous-peripheral-t-cell-lymphoma-unspecified-with-generalized-benign-looking-dermatitis-a-possibly-distinct-peripheral-t-cell-lymphoma
#20
Woo Jin Lee, Hyun Ji Kang, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, Mi Woo Lee
BACKGROUND: Cutaneous lymphomas are a heterogeneous group of tumors with various clinical manifestations, histological features, and prognoses. METHODS: Among 425 cases of cutaneous lymphoma, we describe eight cases of peripheral T-cell lymphoma, unspecified, presenting with generalized benign-looking dermatitis. RESULTS: Our case series included eight cases of secondary cutaneous peripheral T-cell lymphoma, unspecified. The observed clinical morphology features included drug eruption-like generalized morbilliform maculopatches in two cases, generalized folliculitis-like papules in two cases, and generalized eczematous dermatitis-like papules and patches in four cases...
February 27, 2017: International Journal of Dermatology
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