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https://www.readbyqxmd.com/read/28928086/mass-spectrometry-based-metabolic-signatures-of-sex-steroids-in-breast-cancer
#1
REVIEW
Man Ho Choi
Owing to controversy over the effects of steroids on breast cancer pathophysiology, comprehensive quantification of steroid hormones has been extensively considered in both clinical practice and biomarker discovery studies. In contrast to the traditional immunoaffinity-based assays, which show cross-reactivity and have poor validity at low levels of sex steroids, mass spectrometry is becoming a promising tool for measuring steroid levels in complex biological specimens. The Endocrine Society has announced and continuously updated on technical advances to apply high-quality breakthroughs in the clinical sciences...
September 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28923722/high-doses-of-ethylenediurea-edu-as-soil-drenches-did-not-increase-leaf-n-content-or-cause-phytotoxicity-in-willow-grown-in-fertile-soil
#2
Evgenios Agathokleous, Elena Paoletti, William J Manning, Mitsutoshi Kitao, Costas J Saitanis, Takayoshi Koike
Ground-level ozone (O3) levels are nowadays elevated in wide regions of the Earth, causing significant effects on plants that finally lead to suppressed productivity and yield losses. Ethylenediurea (EDU) is a chemical compound which is widely used in research projects as phytoprotectant against O3 injury. The EDU mode of action remains still unclear, while there are indications that EDU may contribute to plants with nitrogen (N) when the soil is poor in N and the plants have relatively small leaf area. To reveal whether the N content of EDU acts as a fertilizer to plants when the soil is not poor in N and the plants have relatively large total plant leaf area, willow plants (Salix sachalinensis Fr...
September 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918154/hot-topic-geographical-distribution-and-strain-diversity-of-lactobacillus-wasatchensis-isolated-from-cheese-with-unwanted-gas-formation
#3
Michele Culumber, Donald J McMahon, Fatih Ortakci, Lauren Montierth, Beatriz Villalba, Jeffery R Broadbent, Craig J Oberg
Lactobacillus wasatchensis, an obligate heterofermentative nonstarter lactic acid bacteria (NSLAB) implicated in causing gas defects in aged cheeses, was originally isolated from an aged Cheddar produced in Logan, Utah. To determine the geographical distribution of this organism, we isolated slow-growing NSLAB from cheeses collected in different regions of the United States, Australia, New Zealand, and Ireland. Seven of the cheeses showed significant gas defects and 12 did not. Nonstarter lactic acid bacteria were isolated from these cheeses on de Man, Rogosa, and Sharpe medium supplemented with ribose, a preferred substrate for Lb...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917259/successful-treatment-with-hyperbaric-oxygen-therapy-for-pneumatosis-cystoides-intestinalis-as-a-complication-of-granulomatosis-with-polyangiitis-a-case-report
#4
Kensuke Nakatani, Takaharu Kato, Shinichiro Okada, Risa Matsumoto, Kazuhiro Nishida, Hiroyasu Komuro, Toshiyuki Suganuma
BACKGROUND: Although gastrointestinal involvement in patients with granulomatosis with polyangiitis is uncommon, it is associated with mild to severe life-threatening complications. We present a case of pneumatosis cystoides intestinalis in a patient with granulomatosis with polyangiitis that was treated successfully with hyperbaric oxygen. CASE PRESENTATION: A 70-year-old Japanese man with a 3-year history of granulomatosis with polyangiitis consulted our hospital with a complaint of severe back pain...
September 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28915807/descemet-membrane-detachment-in-femtosecond-laser-assisted-cataract-surgery-a-case-report
#5
Peiqing Chen, Yanan Zhu, Ke Yao
BACKGROUND: Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design. CASE PRESENTATION: An 85-year-old man with apparent cornea arcus senilis underwent femtosecond laser-assisted cataract surgery in his right eye. A biplanar model was chosen for the main incision...
September 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28898792/laparoscopic-management-for-spontaneous-jejunal-perforation-caused-by-nonspecific-ulcer-a-case-report
#6
Tatsuma Sakaguchi, Katsuji Tokuhara, Kazuyoshi Nakatani, Masanori Kon
INTRODUCTION: Nonspecific small bowel ulcers are rare and there have been limited reports. We applied laparoscopic surgery successfully for the perforation caused by this disease of jejunum. PRESENTATION OF CASE: A 70-year-old man visited to our hospital with complaint of abdominal pain and fever. He was diagnosed abdominal peritonitis with findings of intraperitoneal gas and fluid. Emergency laparoscopic surgery was performed. A perforation 5mm in diameter was recognized in jejunum opposite side of mesentery...
September 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28870011/inhibitory-effect-of-an-ethanol-extract-of-a-rice-bran-mixture-including-angelica-gigas-cnidium-officinale-artemisia-princeps-and-camellia-sinensis-on-brucella-abortus-uptake-by-professional-and-non-professional-phagocytes
#7
Huynh Tan Hop, Lauren Togonon Arayan, Alisha Wehdnesday Bernardo Reyes, Tran Xuan Ngoc Huy, Eun Jin Baek, WonGi Min, Hu Jang Lee, Chun Hee Lee, Man Hee Rhee, Suk Kim
In this study, we evaluated the inhibitory effect of a rice bran mixture extract (RBE) on Brucella (B.) abortus pathogenesis in professional (RAW 264.7) and non-professional (HeLa) phagocytes. We fermented the rice bran mixture and then extracted with 50% ethanol followed by gas chromatography-mass spectrometry to identify components in RBE. Our results clearly showed that RBE caused a significant reduction in the adherence of B. abortus in both cell lines. Furthermore, analysis of phagocytic signaling proteins by Western blot revealed that RBE pretreatment resulted in inhibition of phosphorylation of JNK, ERK and p38, leading to decline of internalization compared with the controls...
September 5, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28865332/metabolomic-study-for-monitoring-of-biomarkers-in-mouse-plasma-with-asthma-by-gas-chromatography-mass-spectrometry
#8
Chan Seo, Yun-Ho Hwang, Hyeon-Seong Lee, Youngbae Kim, Tae Hwan Shin, Gwang Lee, Young-Jin Son, Hangun Kim, Sung-Tae Yee, Ae Kyung Park, Man-Jeong Paik
Asthma is a multifaceted chronic disease caused by an alteration of various genetic and environmental factors that is increasing in incidence worldwide. However, the biochemical mechanisms regarding asthma are not completely understood. Thus, we performed of metabolomic study for understanding of the biochemical events by monitoring of altered metabolism and biomarkers in asthma. In mice plasma, 27 amino acids(AAs), 24 fatty acids(FAs) and 17 organic acids(OAs) were determined by ethoxycarbonyl(EOC)/methoxime(MO)/tert-butyldimethylsilyl(TBDMS) derivatives with GC-MS...
August 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28862705/membrane-and-genomic-dna-dual-targeting-of-citrus-flavonoid-naringenin-against-staphylococcus-aureus
#9
Lang-Hong Wang, Man-Sheng Wang, Xin-An Zeng, Xi-Ming Xu, Charles S Brennan
The antimicrobial mechanism of naringenin, one of the citrus antibacterial flavonoids against food-borne Staphylococcus aureus ATCC 6538, was investigated in this study. Analysis of gas chromatography-mass spectrometry (GC-MS) and fluorescence showed that relatively low concentrations of naringenin caused perturbations in the membrane fatty acid composition and the conformation of membrane proteins through changing the microenvironment of phenylalanine, tyrosine, and tryptophan residues. Exposure of naringenin at higher levels significantly increased membrane permeability and changed the morphology of S...
September 1, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28861268/diagnostic-laparoscopy-for-pneumatosis-intestinalis-in-a-very-elderly-patient-a-case-report
#10
Shuhei Ito, Takaaki Masuda, Noboru Harada, Ayumi Matsuyama, Motoharu Hamatake, Takashi Maeda, Shinichi Tsutsui, Hiroyuki Matsuda, Koshi Mimori, Teruyoshi Ishida
INTRODUCTION: Pneumatosis intestinalis is rare but may be associated with life-threatening intra-abdominal conditions such as intestinal ischemia or perforation. However, it can be difficult, particularly in the very elderly, to identify candidates for immediate surgical intervention. PRESENTATION OF CASE: A 94-year-old man with abdominal distension underwent abdominal computed tomography, which demonstrated accumulation of air bubbles within the intestinal wall and some free intraperitoneal air, suggestive of pneumatosis intestinalis...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28844544/case-of-78-year-old-male-with-cerebral-gas-embolism-associated-with-combined-pulmonary-fibrosis-and-emphysema
#11
Yuichiro Shirota, Takahiro Nakayama, Mizuki Kitamura, Ichiro Imafuku
Cerebral gas embolism (CGE) from the thoracic cavity is commonly associated with invasive procedures, and cases of spontaneous CGE are rare. A 78-year-old man presented with severe spontaneous CGE associated with combined pulmonary fibrosis and emphysema (CPFE). To the best of our knowledge, the comorbidity of CGE in a CPFE patient has not been documented until now. The patient became unconscious with left hemiparesis at approximately 2 a.m. Computed tomography scan revealed minute air densities scattered in the deep white matter of the right frontal lobe...
August 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28838565/a-case-of-methemoglobinemia-successfully-treated-with-hyperbaric-oxygenation-monotherapy
#12
Youngmo Cho, Sung Wook Park, Sang-Kyoon Han, Hyung Bin Kim, Seok Ran Yeom
BACKGROUND: Methylene blue is the first-line therapy for methemoglobinemia, but it can be intermittently unavailable due to production issues. For this clinical scenario, alternative treatment options need to be explored. Hyperbaric oxygenation (HBO) is conventionally applied as an adjunctive therapy during the systemic administration of methylene blue. Currently, little is known regarding the effects of HBO monotherapy in methemoglobinemia. We report a case of methemoglobinemia that was successfully treated with HBO monotherapy...
August 21, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28831761/laparoscopic-repair-of-parahiatal-hernia-after-esophagectomy-a-case-report
#13
Yuji Akiyama, Takeshi Iwaya, Fumitaka Endo, Takehiro Chiba, Takeshi Takahara, Koki Otsuka, Hiroyuki Nitta, Keisuke Koeda, Masaru Mizuno, Yusuke Kimura, Akira Sasaki
BACKGROUND: Diaphragmatic hernia is a potential complication of esophagectomy, which usually occurs as a hiatal hernia and more frequently after minimally invasive esophagectomy. Parahiatal hernia is a rare form of diaphragmatic hernia, and to the best of our knowledge, parahiatal hernia after esophagectomy has not been previously reported. Here, we report a case of parahiatal hernia after esophagectomy that was successfully managed laparoscopically. CASE PRESENTATION: A 73-year-old man underwent thoracoscopic esophagectomy for esophageal cancer with gastric tube reconstruction via the posterior mediastinum...
August 23, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28828518/favorable-outcome-of-conservative-management-of-extensive-bladder-ischemia-complicating-prostatic-artery-embolization
#14
Hippocrates Moschouris, Konstantinos Stamatiou, Ioannis Kornezos, Victoria Kartsouni, Katerina Malagari
This is a report of a case of bladder ischemia which complicated bilateral prostatic artery embolization in an 80-year-old man with benign prostate hyperplasia and indwelling bladder catheter. Reflux of 100 μm microspheres into superior vesical arteries was the most likely cause. An unenhanced computed tomography (CT) scan performed immediately post-embolization showed retention of contrast in the left anterolateral bladder wall. Five days later, CT showed gas collections and dehiscence of the bladder wall at the same site, involving an area of 47 × 42 mm...
August 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28821709/assessment-of-the-announced-north-korean-nuclear-test-using-long-range-atmospheric-transport-and-dispersion-modelling
#15
Pieter De Meutter, Johan Camps, Andy Delcloo, Piet Termonia
On 6 January 2016, the Democratic People's Republic of Korea announced to have conducted its fourth nuclear test. Analysis of the corresponding seismic waves from the Punggye-ri nuclear test site showed indeed that an underground man-made explosion took place, although the nuclear origin of the explosion needs confirmation. Seven weeks after the announced nuclear test, radioactive xenon was observed in Japan by a noble gas measurement station of the International Monitoring System. In this paper, atmospheric transport modelling is used to show that the measured radioactive xenon is compatible with a delayed release from the Punggye-ri nuclear test site...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28791069/outcome-of-macular-hole-surgery-in-bietti-crystalline-dystrophy
#16
Ramin Nourinia, Mohammad Hossein Dehghan, Sahba Fekri
PURPOSE: To describe a 42-year-old man, a known case of Bietti crystalline dystrophy who underwent surgery for unilateral full thickness macular hole. CASE REPORT: Clinical features, color fundus photographs, and optical coherence tomography, electroretinography, and electrooculography findings of the patient are reported. His visual acuity improved from counting fingers to 20/50 after pars plana deep vitrectomy with internal limiting membrane (ILM) peeling and gas injection...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28764707/delayed-anastomotic-leakage-following-laparoscopic-intersphincteric-resection-for-lower-rectal-cancer-report-of-four-cases-and-literature-review
#17
Masayoshi Iwamoto, Kenji Kawada, Koya Hida, Suguru Hasegawa, Yoshiharu Sakai
BACKGROUND: Anastomotic leakage (AL) is one of the most dreadful postoperative complications because it can result in increased morbidity and mortality as well as poorer long-term prognosis. Although most studies of AL limited their investigation time to a period of 30 days postoperatively, only a few studies have shown that AL can occur after that period. Here, we report four patients of rectal cancer with delayed AL following laparoscopic intersphincteric resection (ISR) and conduct a literature review on delayed AL...
August 1, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28753141/atrial-esophageal-fistula-secondary-to-ablation-for-atrial-fibrillation-a-case-series-and-review-of-the-literature
#18
Lily K Fatula, William D Bolton, Allyson L Hale, Barry R Davis, James E Stephenson, Sharon Ben-Or
This article describes 2 patients who presented to our institution with left atrial esophageal fistula after atrial fibrillation ablation; it also compares our experience with other atrial esophageal fistula cases reported in the literature. We performed a retrospective review of 2 patients who presented to our hospital between July 2015 and September 2015 with atrial esophageal fistula. Patient A, a 57-year-old man, presented 31 days postablation with a fever and right-sided weakness. A chest computed tomography showed gas in the left atrium and esophagus; an echocardiogram confirmed the diagnosis of atrial esophageal fistula...
July 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28740394/a-case-of-iatrogenic-pneumothorax-in-which-chest-tube-placement-could-be-avoided-by-intraoperative-evaluation-with-transthoracic-ultrasonography
#19
Izumi Sato, Hirotsugu Kanda, Megumi Kanao-Kanda, Atsushi Kurosawa, Takayuki Kunisawa
We report a case of iatrogenic pneumothorax in which chest tube placement was avoided by continuous intraoperative evaluation with transthoracic ultrasonography. A 53-year-old man had undergone a subsegmentectomy. While attempting to place a central venous catheter in the right internal jugular vein after the induction of anesthesia, we identified gas absorption during the puncture and suspected a pneumothorax. Chest X-ray revealed an ~5-mm collapse of the right lung apex. Tension pneumothorax was a concern during surgery because of the long-term positive pressure ventilation, but we decided to start the operation without preventative chest tube placement...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28727387/focal-cryotherapy-step-by-step-technique-description
#20
Cristina Redondo, Victor Srougi, José Batista da Costa, Mohammed Baghdad, Guillermo Velilla, Igor Nunes-Silva, Sebastien Bergerat, Silvia Garcia-Barreras, François Rozet, Alexandre Ingels, Marc Galiano, Rafael Sanchez-Salas, Eric Barret, Xavier Cathelineau
INTRODUCTION AND OBJECTIVE: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa). The purpose of this video is to describe the procedure step by step. MATERIALS AND METHODS: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. RESULTS: The procedure is performed under general anesthesia, with the patient in lithotomy position. Briefly, the equipament utilized includes the cryotherapy console coupled with an ultrasound system, argon and helium gas bottles, cryoprobes, temperature probes and an urethral warming catheter...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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