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Breast mr

Katie M Parkins, Amanda M Hamilton, Ashley V Makela, Yuanxin Chen, Paula J Foster, John A Ronald
Cellular MRI involves sensitive visualization of iron-labeled cells in vivo but cannot differentiate between dead and viable cells. Bioluminescence imaging (BLI) measures cellular viability, and thus we explored combining these tools to provide a more holistic view of metastatic cancer cell fate in mice. Human breast carcinoma cells stably expressing Firefly luciferase were loaded with iron particles, injected into the left ventricle, and BLI and MRI were performed on days 0, 8, 21 and 28. The number of brain MR signal voids (i...
October 21, 2016: Scientific Reports
Young Gyung Shin, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, Hee Jung Moon
Purpose: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). Methods: Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups...
August 29, 2016: Ultrasonography
Sung Eun Song, Min Sun Bae, Jung Min Chang, Nariya Cho, Han Suk Ryu, Woo Kyung Moon
BACKGROUND: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer has two distinct subtypes according to hormone receptor (HR) status. Survival, pattern of recurrence, and treatment response differ between HR-/HER2+ and HR+/HER2+ cancers. PURPOSE: To investigate imaging and clinicopathologic features of HER2+ cancers and their correlation with HR expression. MATERIAL AND METHODS: Between 2011 and 2013, 252 consecutive patients with 252 surgically confirmed HER2+ cancers (125 HR- and 127 HR+) were included...
October 17, 2016: Acta Radiologica
Atsushi Mizuma, Chikage Kijima, Eiichiro Nagata, Shunya Takizawa
Metastasis of breast cancer is often detected through a long-term course and difficult to diagnose. We report a case of brachial plexopathy suspected to be the initial lesion of breast cancer metastasis, which was only detected by magnetic resonance (MR) neurography. A 61-year-old woman was admitted to our hospital within 2 years after operation for breast cancer because of progressive dysesthesia and motor weakness initially in the upper limb on the affected side and subsequently on the contralateral side...
May 2016: Case Reports in Oncology
Linda Linton, Monica Taylor, Sheila Dunn, Lisa Martin, Sonia Chavez, Greg Stanitz, Ella Huszti, Salomon Minkin, Norman Boyd
BACKGROUND: In previous work in young women aged 15-30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle...
2016: PloS One
Min Sun Bae, Su Hyun Lee, A Jung Chu, Sung Ui Shin, Han Suk Ryu, Woo Kyung Moon
Purpose To determine additional cancer yield of magnetic resonance (MR) imaging in women with breast cancer detected at screening ultrasonography (US) and to identify a subgroup of women who are likely to benefit from preoperative MR imaging. Materials and Methods This study was approved by the institutional review board, and the requirement for informed consent was waived. A retrospective review of 374 women (median age, 48 years; age range, 30-74 years) with breast cancer detected at screening US (invasive, n = 321) who underwent preoperative breast MR imaging between 2007 and 2013 was performed...
October 6, 2016: Radiology
Jae-Hun Kim, Eun Sook Ko, Yaeji Lim, Kyung Soo Lee, Boo-Kyung Han, Eun Young Ko, Soo Yeon Hahn, Seok Jin Nam
Purpose To determine the relationship between tumor heterogeneity assessed by means of magnetic resonance (MR) imaging texture analysis and survival outcomes in patients with primary breast cancer. Materials and Methods Between January and August 2010, texture analysis of the entire primary breast tumor in 203 patients was performed with T2-weighted and contrast material-enhanced T1-weighted subtraction MR imaging for preoperative staging. Histogram-based uniformity and entropy were calculated. To dichotomize texture parameters for survival analysis, the 10-fold cross-validation method was used to determine cutoff points in the receiver operating characteristic curve analysis...
October 4, 2016: Radiology
Savannah C Partridge, Noam Nissan, Habib Rahbar, Averi E Kitsch, Eric E Sigmund
: Diffusion-weighted MRI (DWI) holds potential to improve the detection and biological characterization of breast cancer. DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI. Potential benefits include improved differentiation of benign and malignant breast lesions, assessment and prediction of therapeutic efficacy, and noncontrast detection of breast cancer. The breast presents a unique imaging environment with significant physiologic and inter-subject variations, as well as specific challenges to achieving reliable high quality diffusion-weighted MR images...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Elżbieta Jodłowska, Rafał Czepczyński, Agata Czarnywojtek, Amanda Rewers, Grażyna Jarząbek, Witold Kędzia, Marek Ruchała
Similarly to the applications described in the first part of this publication, positron emission tomography with computed tomography (PET/CT) is also gaining importance in monitoring a tumour's response to therapy and diagnosing breast cancer recurrences. This is additionally caused by the fact that many new techniques (dual-time point imaging, positron emission tomography with magnetic resonance PET/MR, PET/CT mammography) and radiotracers (16α-18F-fluoro-17β-estradiol, 18F-fluorothymidine) are under investigation...
2016: Contemporary Oncology Współczesna Onkologia
Carlo Cavedon, Gabriele Meliadò, Linda Rossi, Lucia Camera, Ilaria Baglio, Francesca Caumo, Stefania Montemezzi
INTRODUCTION: The aim of this work was to assess the role of 3T-MR spectroscopy (MRS) in the multi-parametric MRI evaluation of breast lesions, using a pattern-recognition based classification method. METHODS: 291 patients (301 lesions, median 2.3cm(3)) were enrolled in the study (age 18-85y, mean 54.2y). T1-TSE (TR/TE=400/10ms) and T2-STIR imaging (TR/TE=5000/60ms), dynamic-contrast-enhanced MRI (DCE-MRI), apparent diffusion coefficient (ADC) (b=0-800s/mm(2)), and single-voxel MRS (10×10×10mm(3), PRESS, TR/TE=3000ms/135ms) were performed by means of a 3T scanner...
September 13, 2016: Physica Medica: PM
Clemens G Kaiser, Pascal Baltzer, Anna K Kaiser, Julia Krammer, Michael Uder, Werner A Kaiser, Matthias Dietzel
PURPOSE: To examine "constant lesion sharpness" as a morphological diagnostic sign in the differential diagnosis between benign and malignant lesions. MATERIAL AND METHODS: This prospective study had institutional review board approval and was HIPAA compliant. In total 1014 consecutive patients were examined (mean age 55 years ± 13 years) and evaluated in our University hospital towards the morphological shape of the lesion borders. The "Constant sharpness Sign" was defined as a lesion remaining continuously sharp for the duration of the dynamic scan...
2016: European Journal of Radiology Open
Emma Stanley, Andrea Cradock, James Bisset, Ciara McEntee, Martin J O'Connell
OBJECTIVES: This study aims to assess the effect of sensory stimulation on patient MRI experience, and to assess whether sensory stimulation has a significant effect on MR image quality. METHODS: Case-control study conducted over 4 months, involving patients undergoing MRI brain, cervical spine, breast and prostate. N=106 patients, 64 cases and 42 controls. Cases underwent sensory stimulation during the scan in the form of a scented cotton pad placed in the scanner near their head and/or calming bird noises played over headphones...
September 9, 2016: British Journal of Radiology
M Funke
Advances in imaging of the female breast have substantially influenced the diagnosis and probably also the therapy and prognosis of breast cancer in the past few years. This article gives an overview of the most important imaging modalities in the diagnosis of breast cancer. Digital mammography is considered to be the gold standard for the early detection of breast cancer. Digital breast tomosynthesis can increase the diagnostic accuracy of mammography and is used for the assessment of equivocal or suspicious mammography findings...
October 2016: Der Radiologe
Samuel L Rice, Kent P Friedman
Hybrid imaging systems have dramatically improved thoracic oncology patient care over the past 2 decades. PET-MR imaging systems have the potential to further improve imaging of thoracic neoplasms, resulting in diagnostic and therapeutic advantages compared with current MR imaging and PET-computed tomography systems. Increasing soft tissue contrast and lesion sensitivity, improved image registration, reduced radiation exposure, and improved patient convenience are immediate clinical advantages. Multiparametric quantitative imaging capabilities of PET-MR imaging have the potential to improve understanding of the molecular mechanisms of cancer and treatment effects, potentially guiding improvements in diagnosis and therapy...
October 2016: PET Clinics
Annasofia Anemone, Lorena Consolino, Dario Livio Longo
OBJECTIVES: X-ray iodinated contrast media have been shown to generate contrast in MR images when used with the chemical exchange saturation transfer (CEST) approach. The aim of this study is to compare contrast enhancement (CE) capabilities and perfusion estimates between radiographic molecules and a Gd-based contrast agent in two tumour murine models with different vascularization patterns. METHODS: MRI-CEST and MRI-CE T1w images were acquired in murine TS/A and 4 T1 breast tumours upon sequential i...
August 29, 2016: European Radiology
Jennifer Gillman, Jennifer Chun, Shira Schwartz, Freya Schnabel, Linda Moy
PURPOSE: The purpose was to evaluate the relationship between body mass index (BMI), mammographic breast density, magnetic resonance (MR) background parenchymal enhancement (BPE), and MR fibroglandular tissue (FGT) in women with breast cancer. METHODS: Our institutional database was queried for patients with preoperative mammography and breast MR imaging. RESULTS: There were 573 women eligible for analysis. Elevated BMI was associated with advanced stage of disease (P=...
August 12, 2016: Clinical Imaging
Antonella Petrillo, Roberta Fusco, Salvatore Filice, Vincenza Granata, Orlando Catalano, Paolo Vallone, Maurizio Di Bonito, Massimiliano D'Aiuto, Massimo Rinaldo, Immacolata Capasso, Mario Sansone
PURPOSE: To obtain breast vascular map and to assess correlation between predominant feeding vessel and tumor location with a semi-automatic method compared to conventional radiologic reading. METHODS: 148 malignant and 75 benign breast lesions were included. All patients underwent bilateral MR imaging. Written informed consent was obtained from the patients before MRI. The local ethics committee granted approval for this study. Semi-automatic breast vascular map and predominant vessel detection was performed on MRI, for each patient...
2016: PloS One
Woo Jung Choi, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Eun Young Chae
BACKGROUND: The objective of the study was to compare the accuracy of different magnetic resonance (MR) sequences for measuring tumor size and to evaluate whether the imaging and histopathologic features affect the accuracy of the tumor size estimation on the MR sequence. PATIENTS AND METHODS: Eight hundred women were included. The maximum diameter of the tumor was measured on T2-weighted (T2W) sequences, early-subtracted dynamic contrast-enhanced (DCE) T1-weighted (T1W) sequences, and maximal intensity projection (MIP) reconstructions...
July 29, 2016: Clinical Breast Cancer
Eun Young Chae, Hee Jung Shin, Suhkmann Kim, Hyeon-Man Baek, Dahye Yoon, Siwon Kim, Ye Eun Shim, Hak Hee Kim, Joo Hee Cha, Woo Jung Choi, Jeong Hyun Lee, Ji Hoon Shin, Hee Jin Lee, Gyungyub Gong
The purpose of this study was to evaluate the role of high-resolution magic angle spinning (HR-MAS) 1H nuclear magnetic resonance (NMR) spectroscopy in patients with ductal carcinoma in situ (DCIS) diagnosed on preoperative biopsy. We investigated whether the metabolic profiling of tissue samples using HR-MAS 1H NMR spectroscopy could be used to distinguish between DCIS lesions with or without an invasive component. Our institutional review board approved this combined retrospective and prospective study. Tissue samples were collected from 30 patients with pure DCIS and from 30 with DCIS accompanying invasive carcinoma...
2016: PloS One
Somit Mittal, Mohd Khalid, Aamir Bin Sabir, Saifullah Khalid
STUDY DESIGN: Retrospective study. PURPOSE: To note the magnetic resonance imaging (MRI) differences between pathologically proven cases of atypical spinal tuberculosis and spinal metastasis in 40 cases. OVERVIEW OF LITERATURE: Spinal tuberculosis, or Pott's spine, constitutes less than 1% of all cases of tuberculosis and can be associated with a neurologic deficit. Breast, prostate and lung cancer are responsible for more than 80% of metastatic bone disease cases, and spine is the most common site of bone metastasis...
August 2016: Asian Spine Journal
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