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https://www.readbyqxmd.com/read/29448628/functionalized-magnetic-plga-nanospheres-for-targeting-and-bioimaging-of-breast-cancer
#1
Seung-Jun Lee, Hee-Jin Kim, Yong-Min Huh, Il Won Kim, Jae Hyun Jeong, Jin-Chul Kim, Jong-Duk Kim
Superparamagnetic iron oxide nanoparticles (SPIONs) are actively used as highly sensitive imaging probes to provide contrast in MRI. In this study, we propose the use of SPIONs encapsulated with antibody-conjugated poly(lactic-co-glycolic acid) (PLGA) as a potent theragnostic agent. The SPIONs were synthesized by a chemical co-precipitation method of ferric and ferrous ions, and subsequently encapsulated with PLGA by using an emulsification-diffusion method. Herceptin was chemically conjugated to the SPION-encapsulating PLGA nanoparticles to target the human epidermal growth factor receptor 2 (Her2/neu) overexpressing breast cancers...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446125/feasibility-of-high-spatiotemporal-resolution-for-an-abbreviated-3d-radial-breast-mri-protocol
#2
Jorge E Jimenez, Roberta M Strigel, Kevin M Johnson, Leah C Henze Bancroft, Scott B Reeder, Walter F Block
PURPOSE: To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam. METHODS: A local low-rank temporal reconstruction approach that also uses parallel imaging and spatial compressed sensing was designed to create rapid volumetric frame rates during a contrast-enhanced breast exam (vastly undersampled isotropic projection [VIPR] spatial compressed sensing with temporal local low-rank [STELLR])...
February 14, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29433060/dual-tumor-targeted-multifunctional-magnetic-hyaluronic-acid-micelles-for-enhanced-mr-imaging-and-combined-photothermal-chemotherapy
#3
Shaohui Zheng, Jiwon Han, Zhen Jin, Chang-Sei Kim, Sukho Park, Kyu-Pyo Kim, Jong-Oh Park, Eunpyo Choi
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29427210/a-study-of-association-of-oncotype-dx-recurrence-score-with-dce-mri-characteristics-using-multivariate-machine-learning-models
#4
Ashirbani Saha, Michael R Harowicz, Weiyao Wang, Maciej A Mazurowski
PURPOSE: To determine whether multivariate machine learning models of algorithmically assessed magnetic resonance imaging (MRI) features from breast cancer patients are associated with Oncotype DX (ODX) test recurrence scores. METHODS: A set of 261 female patients with invasive breast cancer, pre-operative dynamic contrast enhanced magnetic resonance (DCE-MR) images and available ODX score at our institution was identified. A computer algorithm extracted a comprehensive set of 529 features from the DCE-MR images of these patients...
February 9, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29413756/the-assessment-of-background-parenchymal-enhancement-bpe-in-a-high-risk-population-what-causes-bpe
#5
Chao You, Anna K Kaiser, Pascal Baltzer, Julia Krammer, Yajia Gu, Weijun Peng, Stefan O Schönberg, Clemens G Kaiser
OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression...
January 27, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29405123/prototype-volumetric-ultrasound-tomography-image-guidance-system-for-prone-stereotactic-partial-breast-irradiation-proof-of-concept
#6
Tsuicheng D Chiu, David Parsons, Yue Zhang, Brian Hrycushko, Bo Zhao, Rajiv Chopra, Nathan Kim, Ann Spangler, Asal Rahimi, Robert D Timmerman, Steve B Jiang, Weiguo Lu, Xuejun Gu
Accurate dose delivery in Stereotactic partial breast irradiation (S-PBI) is challenging because of the target position uncertainty caused by breast deformation, the target volume changes caused by lumpectomy cavity shrinkage, and target delineation uncertainty on simulation computed tomography (CT) images caused by poor soft tissue contrast. We have developed a volumetric ultrasound tomography (UST) image guidance system for prone position S-PBI. The system is composed of a novel 3D printed rotation water tank, a patient-specific resin breast immobilization cup, and a 1D array ultrasound transducer...
February 6, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29399889/local-contrast-enhanced-mr-images-via-high-dynamic-range-processing
#7
Shekhar S Chandra, Craig Engstrom, Jurgen Fripp, Ales Neubert, Jin Jin, Duncan Walker, Olivier Salvado, Charles Ho, Stuart Crozier
PURPOSE: To develop a local contrast-enhancing and feature-preserving high dynamic range (HDR) image processing algorithm for multichannel and multisequence MR images of multiple body regions and tissues, and to evaluate its performance for structure visualization, bias field (correction) mitigation, and automated tissue segmentation. METHODS: A multiscale-shape and detail-enhancement HDR-MRI algorithm is applied to data sets of multichannel and multisequence MR images of the brain, knee, breast, and hip...
February 4, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29397610/-application-of-decision-curve-on-evaluation-of-mri-predictive-model-for-early-assessing-pathological-complete-response-to-neoadjuvant-therapy-in-breast-cancer
#8
Y J He, X T Li, Z Q Fan, Y L Li, K Cao, Y S Sun, T Ouyang
Objective: To construct a dynamic enhanced MR based predictive model for early assessing pathological complete response (pCR) to neoadjuvant therapy in breast cancer, and to evaluate the clinical benefit of the model by using decision curve. Methods: From December 2005 to December 2007, 170 patients with breast cancer treated with neoadjuvant therapy were identified and their MR images before neoadjuvant therapy and at the end of the first cycle of neoadjuvant therapy were collected. Logistic regression model was used to detect independent factors for predicting pCR and construct the predictive model accordingly, then receiver operating characteristic (ROC) curve and decision curve were used to evaluate the predictive model...
January 23, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29392160/distinguishing-benign-and-malignant-breast-tumors-preliminary-comparison-of-kinetic-modeling-approaches-using-multi-institutional-dynamic-contrast-enhanced-mri-data-from-the-international-breast-mr-consortium-6883-trial
#9
Anna G Sorace, Savannah C Partridge, Xia Li, Jack Virostko, Stephanie L Barnes, Daniel S Hippe, Wei Huang, Thomas E Yankeelov
Comparative preliminary analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data collected in the International Breast MR Consortium 6883 multicenter trial was performed to distinguish benign and malignant breast tumors. Prebiopsy DCE-MRI data from 45 patients with suspicious breast lesions were obtained. Semiquantitative mean signal-enhancement ratio ([Formula: see text]) was calculated for all lesions, and quantitative pharmacokinetic, parameters [Formula: see text], [Formula: see text], and [Formula: see text], were calculated for the subset with available [Formula: see text] maps ([Formula: see text])...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29388904/breast-mr-imaging-before-surgery-outcomes-in-patients-with-invasive-lobular-carcinoma-by-using-propensity-score-matching
#10
Su Min Ha, Eun Young Chae, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Woo Jung Choi
Purpose To investigate the association between preoperative breast magnetic resonance (MR) imaging and surgical outcomes in patients with invasive lobular carcinoma (ILC) by using propensity score matching to decide whether MR examination is beneficial in the ILC subtype of breast cancer. Materials and Methods The authors identified 603 patients with ILC who underwent surgery between January 2005 and December 2016. Of the 603 patients, 369 (61.2%) underwent MR imaging. The authors calculated the MR detection rate of additional lesions that were occult at mammography and ultrasonography and analyzed any alterations in surgical management...
January 31, 2018: Radiology
https://www.readbyqxmd.com/read/29388800/stromal-fibrosis-imaging-features-with-diagnostic-contribution-of-diffusion-weighted-mr-imaging
#11
Ravza Yilmaz, Zuhal Bayramoglu, Merve Gulbiz Kartal, Emine Caliskan, Artur Salmaslioglu, Memduh Dursun, Gulden Acunas
OBJECTIVE: To describe magnetic resonance imaging (MRI) and ultrasonography (US) findings of breast stromal fibrosis (SF) and compare apparent diffusion coefficient (ADC) stromal fibrosis values with breast cancer and normal parenchyma. METHODS: Forty-five patients (ages 22‒74) with histopathologically proven SF who underwent MRI were included in this study. Their MRI and US features were examined and categorized. The mean ADC values for SF contralateral normal parenchyma, and breast malignancy of the control group values were calculated and compared among each other...
February 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29386472/assessment-of-the-quality-of-breast-mr-imaging-using-the-modified-dixon-method-and-frequency-selective-fat-suppression-a-phantom-study
#12
Yasuo Takatsu, Katsusuke Kyotani, Tsuyoshi Ueyama, Tosiaki Miyati, Kenichirou Yamamura, Atsushi Andou
To obtain objective and concrete data by physically assessing the quality of breast magnetic resonance images based on the fat-suppression effect by the modified Dixon method (mDixon) and frequency-selective fat suppression (e-Thrive) using an original lipid-content breast phantom that could easily reveal the influence of non-uniform fat suppression in breast magnetic resonance imaging. The fat-suppression uniformity was approximately seven times superior when using mDixon compared with when using e-Thrive...
January 30, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29380033/contrast-enhanced-mri-after-neoadjuvant-chemotherapy-of-breast-cancer-lesion-to-background-parenchymal-signal-enhancement-ratio-for-discriminating-pathological-complete-response-from-minimal-residual-tumour
#13
Soo-Yeon Kim, Nariya Cho, Sung Ui Shin, Han-Byoel Lee, Wonshik Han, In Ae Park, Bo Ra Kwon, Soo Yeon Kim, Su Hyun Lee, Jung Min Chang, Woo Kyung Moon
OBJECTIVES: To retrospectively investigate whether the lesion-to-background parenchymal signal enhancement ratio (SER) on breast MRI can distinguish pathological complete response (pCR) from minimal residual cancer following neoadjuvant chemotherapy (NAT), and compare its performance with the conventional criterion. METHODS: 216 breast cancer patients who had undergone NAT and MRI and achieved pCR or minimal residual cancer on surgical histopathology were included...
January 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29372076/effects-of-diffusion-time-on-non-gaussian-diffusion-and-intravoxel-incoherent-motion-ivim-mri-parameters-in-breast-cancer-and-hepatocellular-carcinoma-xenograft-models
#14
Mami Iima, Tomomi Nobashi, Hirohiko Imai, Sho Koyasu, Tsuneo Saga, Yuji Nakamoto, Masako Kataoka, Akira Yamamoto, Tetsuya Matsuda, Kaori Togashi
Background: Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated in tumors. Purpose: To investigate the relationship between diffusion time and diffusion parameters in breast cancer and hepatocellular carcinoma xenograft mouse models...
January 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29371992/prediction-of-low-risk-breast-cancer-using-quantitative-dce-mri-and-its-pathological-basis
#15
Tingting Xu, Lin Zhang, Hong Xu, Sifeng Kang, Yali Xu, Xiaoyu Luo, Ting Hua, Guangyu Tang
Purpose: This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers and to explore the possible pathological basis. Materials and Methods: Approval from the institutional review board and informed consent were acquired for this study. The MR images of 104 patients with pathologically proven breast cancer (104 lesions) were prospectively analyzed...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29357842/breast-magnetic-resonance-imaging-for-surveillance-of-women-with-a-personal-history-of-breast-cancer-outcomes-stratified-by-interval-between-definitive-surgery-and-surveillance-mr-imaging
#16
Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon
BACKGROUND: Women with a personal history of breast cancer are at increased risk of future breast cancer events, and may benefit from supplemental screening methods that could enhance early detection of subclinical disease. However, current literature on breast magnetic resonance (MR) imaging surveillance is limited. We investigated outcomes of surveillance breast magnetic resonance (MR) imaging in women with a personal history of breast cancer. METHODS: We reviewed 1053 consecutive breast MR examinations that were performed for surveillance in 1044 women (median age, 53 years; range, 20-85 years) previously treated for breast cancer between August 2014 and February 2016...
January 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29356636/recall-rate-benchmark-for-screening-breast-mr-imaging-in-community-practice
#17
David Seidenwurm, Jonathan Breslau
No abstract text is available yet for this article.
February 2018: Radiology
https://www.readbyqxmd.com/read/29356631/does-texture-analysis-of-mr-images-of-breast-tumors-help-predict-response-to-treatment
#18
Massimo Imbriaco, Renato Cuocolo
No abstract text is available yet for this article.
February 2018: Radiology
https://www.readbyqxmd.com/read/29351560/the-correlation-of-background-parenchymal-enhancement-in-the-contralateral-breast-with-patient-and-tumor-characteristics-of-mri-screen-detected-breast-cancers
#19
Suzan Vreemann, Albert Gubern-Mérida, Cristina Borelli, Peter Bult, Nico Karssemeijer, Ritse M Mann
PURPOSE: Higher background parenchymal enhancement (BPE) could be used for stratification of MRI screening programs since it might be related to a higher breast cancer risk. Therefore, the purpose of this study is to correlate BPE to patient and tumor characteristics in women with unilateral MRI-screen detected breast cancer who participated in an intermediate and high risk screening program. As BPE in the affected breast may be difficult to discern from enhancing cancer, we assumed that BPE in the contralateral breast is a representative measure for BPE in women with unilateral breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29341018/magnetic-resonance-spectroscopy-studies-of-mouse-models-of-cancer
#20
Menglin Cheng, Kristine Glunde
Magnetic resonance spectroscopy (MRS) or spectroscopic imaging (MRSI) enables the detection of metabolites, amino acids, and lipids, among other biomolecules, in tumors of live mouse models of cancer. Tumor-bearing mice are anesthetized by breathing isoflurane in a magnetic resonance (MR) scanner dedicated to small animal MR. Here we describe the overall setup and steps for measuring 1H and 31P MRS and 1H MRSI of orthotopic breast tumor models in mice with surface coils. This protocol can be adapted to the use of volume coils to measure 1H and 31P MRS(I) of tumor models that grow inside the body...
2018: Methods in Molecular Biology
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