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https://www.readbyqxmd.com/read/27895875/takeaways-from-pre-contrast-t1-and-t2-breast-magnetic-resonance-imaging-in-women-with-recently-diagnosed-breast-cancer
#1
Seung Hee Han, Yeong Yi An, Bong Joo Kang, Sung Hun Kim, Eun Jae Lee
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE - MRI) has been widely used in the management of breast cancer, and its diagnostic value in breast imaging has been demonstrated. There have only been a few reports regarding the usefulness of pre-contrast imaging. Knowledge about clinically significant findings of preoperative, pre-contrast T1 and T2 MR images will allow more accurate decisions regarding patient treatment and management. OBJECTIVES: The aim of this study was to evaluate the clinically significant findings of preoperative, pre-contrast T1 and T2 MR images in recently diagnosed breast cancer patients...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27879583/breast-tissue-expanders-with-magnetic-ports-clinical-experience-at-1-5-t
#2
Nanda Deepa Thimmappa, Martin R Prince, Kari L Colen, Christina Y Ahn, Silvina P Dutruel, Srikanth R Boddu, David T Greenspun, Julie V Vasile, Constance M Chen, Hakan Usal, Christine H Rohde, Jeremiah S Redstone, Maria M LoTempio, Oren Z Lerman, Anik K Nath, Robert J Allen, Joshua L Levine
BACKGROUND: The purpose of this study was to evaluate breast tissue expanders with magnetic ports for safety in patients undergoing abdominal/pelvic magnetic resonance angiography before autologous breast reconstruction. METHODS: Magnetic resonance angiography of the abdomen and pelvis at 1.5 T was performed in 71 patients in prone position with tissue expanders with magnetic ports labeled "MR Unsafe" from July of 2012 to May of 2014. Patients were monitored during magnetic resonance angiography for tissue expander-related symptoms, and the chest wall tissue adjacent to the tissue expander was examined for injury at the time of tissue expander removal for breast reconstruction...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27875106/neoadjuvant-systemic-therapy-in-breast-cancer-association-of-contrast-enhanced-mr-imaging-findings-diffusion-weighted-imaging-findings-and-tumor-subtype-with-tumor-response
#3
Gorane Santamaría, Xavier Bargalló, Pedro Luis Fernández, Blanca Farrús, Xavier Caparrós, Martin Velasco
Purpose To investigate the performance of tumor subtype and various magnetic resonance (MR) imaging parameters in the assessment of tumor response to neoadjuvant systemic therapy (NST) in patients with breast cancer and to outline a model of pathologic response, considering pathologic complete response (pCR) as the complete absence of any residual invasive cancer or ductal carcinoma in situ (DCIS). Materials and Methods This was an institutional review board-approved retrospective study, with waiver of the need to obtain informed consent...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27861232/safety-and-efficacy-of-magnetic-resonance-guided-vacuum-assisted-large-volume-breast-biopsy-mr-guided-valb
#4
Simone Schrading, Kevin Strobel, Annika Keulers, Timm Dirrichs, Christiane K Kuhl
OBJECTIVE: Magnetic resonance (MR)-guided vacuum-biopsy is technically demanding and may fail depending on target-lesion size or breast size, and location of lesions within the breast. We developed an MR-guided vacuum-assisted biopsy protocol that collects larger amounts of tissue, aiming at an at least partial or complete ablation of the target-lesion, just as it is intended during surgical (excisional) biopsy. Rationale is to avoid biopsy failures (false-negative results due to undersampling) by collecting larger amounts of tissue...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27859861/development-of-a-7%C3%A2-t-rf-coil-system-for-breast-imaging
#5
Junghwan Kim, Tales Santini, Kyongtae Ty Bae, Narayan Krishnamurthy, Yujuan Zhao, Tiejun Zhao, Tamer S Ibrahim
In ultrahigh-field MRI, such as 7 T, the signal-to-noise ratio (SNR) increases while transmit (Tx) field (B1(+) ) can be degraded due to inhomogeneity and elevated specific absorption rate (SAR). By applying new array coil concepts to both Tx and receive (Rx) coils, the B1(+) homogeneity and SNR can be improved. In this study, we developed and tested in vivo a new RF coil system for 7 T breast MRI. An RF coil system composed of an eight-channel Tx-only array based on a tic-tac-toe design (can be combined to operate in single-Tx mode) in conjunction with an eight-channel Rx-only insert was developed...
November 11, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27853751/quantitative-mri-radiomics-in-the-prediction-of-molecular-classifications-of-breast-cancer-subtypes-in-the-tcga-tcia-data-set
#6
Hui Li, Yitan Zhu, Elizabeth S Burnside, Erich Huang, Karen Drukker, Katherine A Hoadley, Cheng Fan, Suzanne D Conzen, Margarita Zuley, Jose M Net, Elizabeth Sutton, Gary J Whitman, Elizabeth Morris, Charles M Perou, Yuan Ji, Maryellen L Giger
Using quantitative radiomics, we demonstrate that computer-extracted magnetic resonance (MR) image-based tumor phenotypes can be predictive of the molecular classification of invasive breast cancers. Radiomics analysis was performed on 91 MRIs of biopsy-proven invasive breast cancers from National Cancer Institute's multi-institutional TCGA/TCIA. Immunohistochemistry molecular classification was performed including estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and for 84 cases, the molecular subtype (normal-like, luminal A, luminal B, HER2-enriched, and basal-like)...
2016: NPJ Breast Cancer
https://www.readbyqxmd.com/read/27835038/family-matters-collaboration-and-conflict-among-the-steroid-receptors-raises-a-need-for-group-therapy
#7
Matthew J Sikora
Antiestrogen therapies targeting the function of estrogen receptor (ER) have been the cornerstone of therapy for ER+ breast cancer for decades. However, as long as these therapies have been in use, it has also been evident that response to antiestrogen therapy is not based solely on ER expression but that other factors modify breast cancer antiestrogen response. Such factors may include ER's relatives in the steroid hormone receptor (HR) family, androgen receptor (AR), progesterone receptor (PR), glucocorticoid receptor (GR), and mineralocorticoid receptor (MR)...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27814819/an-abbreviated-protocol-for-high-risk-screening-breast-mri-saves-time-and-resources
#8
Susan C Harvey, Phillip A Di Carlo, Bonmyong Lee, Eniola Obadina, Dorothy Sippo, Lisa Mullen
PURPOSE: To review the ability of an abbreviated, high-risk, screening, breast MRI protocol to detect cancer and save resources. METHODS: High-risk screening breast MR images were reviewed, from both an abbreviated protocol and a full diagnostic protocol. Differences in cancer detection, scanner utilization, interpretation times, and need for additional imaging were recorded in an integrated data form, and reviewed and compared. RESULTS: A total of 568 MRI cases were reviewed, with the abbreviated and full protocols...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27805423/the-potential-of-multiparametric-mri-of-the-breast
#9
Katja Pinker, Thomas H Helbich, Elizabeth A Morris
Magnetic resonance imaging (MRI) is an essential tool in breast imaging, with multiple established indications. Dynamic contrast-enhanced MRI (DCE-MRI) is the backbone of any breast MRI protocol and has an excellent sensitivity and good specificity for breast cancer diagnosis. DCE-MRI provides high-resolution morphological information, as well as some functional information about neo-angiogenesis as a tumour-specific feature. To overcome limitations in specificity, several other functional MRI parameters have been investigated and the application of these combined parameters is defined as multiparametric MRI (mpMRI) of the breast...
November 2, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27790545/the-role-of-mr-mammography-in-differentiating-benign-from-malignant-in-suspicious-breast-masses
#10
Padhmini Balasubramanian, Vijaya Karthikeyan Murugesan, Vinoth Boopathy
INTRODUCTION: Magnetic Resonance (MR) Mammography is being increasingly used now-a-days for the evaluation of breast lesions. AIM: To find out the effectiveness and the exact role of MR mammography in differentiating benign lesions from malignant lesions in patients with palpable, suspicious breast masses found on routine conventional imaging techniques. MATERIALS AND METHODS: It was a prospective study wherein patients with suspicious breast lesions were subjected to MR mammography...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27788960/comparison-of-magnetic-resonance-imaging-and-computed-tomography-for-breast-target-volume-delineation-in-prone-and-supine-positions
#11
Elise M Pogson, Geoff P Delaney, Verity Ahern, Miriam M Boxer, Christine Chan, Steven David, Marion Dimigen, Jennifer A Harvey, Eng-Siew Koh, Karen Lim, George Papadatos, Mei Ling Yap, Vikneswary Batumalai, Elizabeth Lazarus, Kylie Dundas, Jesmin Shafiq, Gary Liney, Catherine Moran, Peter Metcalfe, Lois Holloway
PURPOSE: To determine whether T2-weighted MRI improves seroma cavity (SC) and whole breast (WB) interobserver conformity for radiation therapy purposes, compared with the gold standard of CT, both in the prone and supine positions. METHODS AND MATERIALS: Eleven observers (2 radiologists and 9 radiation oncologists) delineated SC and WB clinical target volumes (CTVs) on T2-weighted MRI and CT supine and prone scans (4 scans per patient) for 33 patient datasets. Individual observer's volumes were compared using the Dice similarity coefficient, volume overlap index, center of mass shift, and Hausdorff distances...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27788951/magnetic-resonance-image-guided-radiation-therapy-for-external-beam-accelerated-partial-breast-irradiation-evaluation-of-delivered-dose-and-intrafractional-cavity-motion
#12
Sahaja Acharya, Benjamin W Fischer-Valuck, Thomas R Mazur, Austen Curcuru, Karl Sona, Rojano Kashani, Olga Green, Laura Ochoa, Sasa Mutic, Imran Zoberi, H Harold Li, Maria A Thomas
PURPOSE: To use magnetic resonance image guided radiation therapy (MR-IGRT) for accelerated partial-breast irradiation (APBI) to (1) determine intrafractional motion of the breast surgical cavity; and (2) assess delivered dose versus planned dose. METHODS AND MATERIALS: Thirty women with breast cancer (stages 0-I) who underwent breast-conserving surgery were enrolled in a prospective registry evaluating APBI using a 0.35-T MR-IGRT system. Clinical target volume was defined as the surgical cavity plus a 1-cm margin (excluding chest wall, pectoral muscles, and 5 mm from skin)...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27788035/mr-imaging-for-diagnosis-of-malignancy-in-mammographic-microcalcifications-a-systematic-review-and-meta-analysis
#13
Barbara Bennani-Baiti, Pascal A Baltzer
Purpose To assess the use of magnetic resonance (MR) imaging for diagnosis of malignancy in lesions that manifest as microcalcifications at mammography. Materials and Methods Two independent readers performed a systematic review of the literature published as of February 1, 2016, by using predefined search terms. All studies in which contrast material-enhanced MR imaging was used for assessment of mammographic microcalcifications that were assigned Breast Imaging Reporting and Data System (BI-RADS) scores of 3-5 were deemed eligible...
October 27, 2016: Radiology
https://www.readbyqxmd.com/read/27780660/clinical-utility-of-real-time-mr-navigated-ultrasound-with-supine-breast-mri-for-suspicious-enhancing-lesions-not-identified-on-second-look-ultrasound
#14
Doo Kyoung Kang, Yongsik Jung, Sehwan Han, Ji Young Kim, Tae Hee Kim
This study evaluated the usefulness of magnetic resonance (MR)-navigated ultrasound (US) for evaluation of magnetic resonance imaging (MRI)-detected lesions not visible on second-look US and analyzed differences in lesion-to-nipple distance between supine and prone positions. Of the 831 consecutive patients who were diagnosed with breast cancer and examined with breast MRI from June 2013 to September 2015, 40 lesions in 37 patients who underwent MR-navigated US for MRI-detected lesions that were not visible on second-look US were included...
October 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27779802/quantification-of-breast-stiffness-using-mr-elastography-at-3-tesla-with-a-soft-sternal-driver-a-reproducibility-study
#15
Jeffrey R Hawley, Prateek Kalra, Xiaokui Mo, Brian Raterman, Lisa D Yee, Arunark Kolipaka
PURPOSE: Previous studies of breast MR elastography (MRE) evaluated the technique at magnetic field strengths of 1.5 Tesla (T) with the breast in contact with the driver. The aim of this study is to evaluate breast stiffness measurements and their reproducibility using a soft sternal driver at 3T and compare the results with qualitative measures of breast density. MATERIALS AND METHODS: Twenty-two healthy volunteers each underwent two separate breast MRE scans in a 3T MRI...
October 25, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27779790/voxelwise-analysis-of-simultaneously-acquired-and-spatially-correlated-18-f-fluorodeoxyglucose-fdg-pet-and-intravoxel-incoherent-motion-metrics-in-breast-cancer
#16
Jason Ostenson, Akshat C Pujara, Artem Mikheev, Linda Moy, Sungheon G Kim, Amy N Melsaether, Komal Jhaveri, Sylvia Adams, David Faul, Christopher Glielmi, Christian Geppert, Thorsten Feiweier, Kimberly Jackson, Gene Y Cho, Fernando E Boada, Eric E Sigmund
PURPOSE: Diffusion-weighted imaging (DWI) and (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG-PET) independently correlate with malignancy in breast cancer, but the relationship between their structural and metabolic metrics is not completely understood. This study spatially correlates diffusion, perfusion, and glucose avidity in breast cancer with simultaneous PET/MR imaging and compares correlations with clinical prognostics. METHODS: In this Health Insurance Portability and Accountability Act-compliant prospective study, with written informed consent and approval of the institutional review board and using simultaneously acquired FDG-PET and DWI, tissue diffusion (Dt ), and perfusion fraction (fp ) from intravoxel incoherent motion (IVIM) analysis were registered to FDG-PET within 14 locally advanced breast cancers...
October 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27767185/a-multimodality-imaging-model-to-track-viable-breast-cancer-cells-from-single-arrest-to-metastasis-in-the-mouse-brain
#17
Katie M Parkins, Amanda M Hamilton, Ashley V Makela, Yuanxin Chen, Paula J Foster, John A Ronald
Cellular MRI involves sensitive visualization of iron-labeled cells in vivo but cannot differentiate between dead and viable cells. Bioluminescence imaging (BLI) measures cellular viability, and thus we explored combining these tools to provide a more holistic view of metastatic cancer cell fate in mice. Human breast carcinoma cells stably expressing Firefly luciferase were loaded with iron particles, injected into the left ventricle, and BLI and MRI were performed on days 0, 8, 21 and 28. The number of brain MR signal voids (i...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27764910/magnetic-resonance-imaging-and-pathological-characteristics-of-pure-mucinous-carcinoma-in-the-breast-according-to-echogenicity-on-ultrasonography
#18
Young Gyung Shin, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, Hee Jung Moon
Purpose: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). Methods: Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups...
August 29, 2016: Ultrasonography
https://www.readbyqxmd.com/read/27754920/mr-and-mammographic-imaging-features-of-her2-positive-breast-cancers-according-to-hormone-receptor-status-a-retrospective-comparative-study
#19
Sung Eun Song, Min Sun Bae, Jung Min Chang, Nariya Cho, Han Suk Ryu, Woo Kyung Moon
BACKGROUND: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer has two distinct subtypes according to hormone receptor (HR) status. Survival, pattern of recurrence, and treatment response differ between HR-/HER2+ and HR+/HER2+ cancers. PURPOSE: To investigate imaging and clinicopathologic features of HER2+ cancers and their correlation with HR expression. MATERIAL AND METHODS: Between 2011 and 2013, 252 consecutive patients with 252 surgically confirmed HER2+ cancers (125 HR- and 127 HR+) were included...
October 17, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27721757/a-case-of-suspected-breast-cancer-metastasis-to-brachial-plexus-detected-by-magnetic-resonance-neurography
#20
Atsushi Mizuma, Chikage Kijima, Eiichiro Nagata, Shunya Takizawa
Metastasis of breast cancer is often detected through a long-term course and difficult to diagnose. We report a case of brachial plexopathy suspected to be the initial lesion of breast cancer metastasis, which was only detected by magnetic resonance (MR) neurography. A 61-year-old woman was admitted to our hospital within 2 years after operation for breast cancer because of progressive dysesthesia and motor weakness initially in the upper limb on the affected side and subsequently on the contralateral side...
May 2016: Case Reports in Oncology
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