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https://www.readbyqxmd.com/read/28221097/supplemental-breast-mr-imaging-screening-of-women-with-average-risk-of-breast-cancer
#1
Christiane K Kuhl, Kevin Strobel, Heribert Bieling, Claudia Leutner, Hans H Schild, Simone Schrading
Purpose To investigate the utility and accuracy of breast magnetic resonance (MR) imaging as a supplemental screening tool in women at average risk for breast cancer and to investigate the types of cancer detected with MR imaging screening. Materials and Methods This prospective observational study was conducted at two academic breast centers in women aged 40-70 years without breast cancer-associated risk factors (lifetime risk <15%). Between January 2005 and December 2013, women with at least minimal residual breast tissue (American College of Radiology categories A-D) and normal conventional imaging findings (screening mammography with or without screening ultrasonography [US]) were invited to undergo supplemental MR imaging screening...
February 21, 2017: Radiology
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#2
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28186859/multimodality-imaging-based-evaluation-of-single-lumen-silicone-breast-implants-for-rupture
#3
Stephen J Seiler, Pooja B Sharma, Jody C Hayes, Ramapriya Ganti, Ann R Mootz, Emily D Eads, Sumeet S Teotia, W Phil Evans
Breast implants are frequently encountered on breast imaging studies, and it is essential for any radiologist interpreting these studies to be able to correctly assess implant integrity. Ruptures of silicone gel-filled implants often occur without becoming clinically obvious and are incidentally detected at imaging. Early diagnosis of implant rupture is important because surgical removal of extracapsular silicone in the breast parenchyma and lymphatics is difficult. Conversely, misdiagnosis of rupture may prompt a patient to undergo unnecessary additional surgery to remove the implant...
February 10, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28185146/mr-imaging-features-associated-with-distant-metastasis-free-survival-of-patients-with-invasive-breast-cancer-a-case-control-study
#4
Sung Eun Song, Sung Ui Shin, Hyeong-Gon Moon, Han Suk Ryu, Kwangsoo Kim, Woo Kyung Moon
PURPOSE: Preoperative breast magnetic resonance (MR) imaging features of primary breast cancers may have the potential to act as prognostic biomarkers by providing morphologic and kinetic features representing inter- or intra-tumor heterogeneity. Recent radiogenomic studies reveal that several radiologist-annotated image features are associated with genes or signal pathways involved in tumor progression, treatment resistance, and distant metastasis (DM). We investigate whether preoperative breast MR imaging features are associated with worse DM-free survival in patients with invasive breast cancer...
February 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28168682/a-magnetic-resonance-image-guided-breast-needle-intervention-robot-system-overview-and-design-considerations
#5
Samuel Byeongjun Park, Jung-Gun Kim, Ki-Woong Lim, Chae-Hyun Yoon, Dong-Jun Kim, Han-Sung Kang, Yung-Ho Jo
PURPOSE: We developed an image-guided intervention robot system that can be operated in a magnetic resonance (MR) imaging gantry. The system incorporates a bendable needle intervention robot for breast cancer patients that overcomes the space limitations of the MR gantry. METHODS: Most breast coil designs for breast MR imaging have side openings to allow manual localization. However, for many intervention procedures, the patient must be removed from the gantry. A robotic manipulation system with integrated image guidance software was developed...
February 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28166261/radiomic-analysis-reveals-dce-mri-features-for-prediction-of-molecular-subtypes-of-breast-cancer
#6
Ming Fan, Hui Li, Shijian Wang, Bin Zheng, Juan Zhang, Lihua Li
The purpose of this study was to investigate the role of features derived from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and to incorporated clinical information to predict the molecular subtypes of breast cancer. In particular, 60 breast cancers with the following four molecular subtypes were analyzed: luminal A, luminal B, human epidermal growth factor receptor-2 (HER2)-over-expressing and basal-like. The breast region was segmented and the suspicious tumor was depicted on sequentially scanned MR images from each case...
2017: PloS One
https://www.readbyqxmd.com/read/28162171/-application-study-of-differentiating-malignant-benign-from-breast-lesions-using-multiple-b-value-dwi
#7
H B Dong, G Y Wang, Y D Li
Objective: To explore the diagnostic value of multi b-value DWI (MB-DWI) in the identification of benign and malignant breast lesions. Methods: From October 2013 to December 2015, a total of 54 cases from Ningbo Medical Center Lihuili Hospital (22 benign cases with a total of 24 lesions, 32 malignant cases with a total of 38 lesions) were examined with conventional MR scan, single b-value DWI, and multiple b-value DWI (0, 10, 20, 30, 50, 100, 200, 400, 800, 1 200, 2 000, 3 000 s/mm(2)). GE ADW4.5 workstation was used to calculate the value of standard apparent diffusion coefficient (ADC(standard)), slow apparent diffusion coefficient(ADC(slow)), fast apparent diffusion coefficient (ADC(fast)) and fraction of ADC(fast)(f(fast))...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28152264/prediction-of-malignancy-by-a-radiomic-signature-from-contrast-agent-free-diffusion-mri-in-suspicious-breast-lesions-found-on-screening-mammography
#8
Sebastian Bickelhaupt, Daniel Paech, Philipp Kickingereder, Franziska Steudle, Wolfgang Lederer, Heidi Daniel, Michael Götz, Nils Gählert, Diana Tichy, Manuel Wiesenfarth, Frederik B Laun, Klaus H Maier-Hein, Heinz-Peter Schlemmer, David Bonekamp
PURPOSE: To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X-ray mammography can be categorized into malignant and benign with unenhanced magnetic resonance (MR) mammography with diffusion-weighted imaging and T2 -weighted sequences. MATERIALS AND METHODS: From an asymptomatic screening cohort, 50 women with mammographically suspicious findings were examined with contrast-enhanced breast MRI (ceMRI) at 1.5T. Out of this protocol an unenhanced, abbreviated diffusion-weighted imaging protocol (ueMRI) including T2 -weighted, (T2 w), diffusion-weighted imaging (DWI), and DWI with background suppression (DWIBS) sequences and corresponding apparent diffusion coefficient (ADC) maps were extracted...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28121639/ultrasound-tomography-evaluation-of-breast-density-a-comparison-with-noncontrast-magnetic-resonance-imaging
#9
Elizabeth A M OʼFlynn, Jeremie Fromageau, Araminta E Ledger, Alessandro Messa, Ashley DʼAquino, Minouk J Schoemaker, Maria Schmidt, Neb Duric, Anthony J Swerdlow, Jeffrey C Bamber
OBJECTIVES: Ultrasound tomography (UST) is an emerging whole-breast 3-dimensional imaging technique that obtains quantitative tomograms of speed of sound of the entire breast. The imaged parameter is the speed of sound which is used as a surrogate measure of density at each voxel and holds promise as a method to evaluate breast density without ionizing radiation. This study evaluated the technique of UST and compared whole-breast volume averaged speed of sound (VASS) with MR percent water content from noncontrast magnetic resonance imaging (MRI)...
January 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28108330/pleiotropic-responses-to-methionine-restriction
#10
Gene P Ables, Jay E Johnson
Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in both organs during MR. In fat, MR induced a futile lipid cycle concomitant with beige AT accumulation, producing elevated energy expenditure. In liver, MR upregulated fibroblast growth factor 21 and improved glucose metabolism in aged mice and in response to a high-fat diet...
January 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28104942/accuracy-of-mri-for-prediction-of-response-to-neo-adjuvant-chemotherapy-in-triple-negative-breast-cancer-compared-to-other-subtypes-of-breast-cancer
#11
Gaurav J Bansal, Divya Santosh
PURPOSE: The aim of this study was to compare the accuracy of magnetic resonance imaging (MRI) for the prediction of response to neo-adjuvant chemotherapy in triple negative (TN) breast cancer, with respect to other subtypes. MATERIALS AND METHODS: There were a total of 1610 breast cancers diagnosed between March 2009 and August 2014, out of which 82 patients underwent MRI before and after neo-adjuvant chemotherapy but just before surgery. TN cancers were analyzed with respect to others subtypes...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28102957/rf-safety-assessment-of-a-bilateral-four-channel-transmit-receive-7-tesla-breast-coil-sar-versus-tissue-temperature-limits
#12
Thomas M Fiedler, Mark E Ladd, Andreas K Bitz
PURPOSE: The purpose of this work was to perform an RF safety evaluation for a bilateral four-channel transmit/receive breast coil and to determine the maximum permissible input power for which RF exposure of the subject stays within recommended limits. The safety evaluation was done based on SAR as well as on temperature simulations. In comparison to SAR, temperature is more directly correlated with tissue damage, which allows a more precise safety assessment. The temperature simulations were performed by applying three different blood perfusion models as well as two different ambient temperatures...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28090007/ductal-carcinoma-in-situ-detected-during-prospective-mr-imaging-screening-of-a-woman-with-a-brca2-mutation-the-first-case-report-in-japan
#13
Mitsuhiro Tozaki, Seigo Nakamura, Dai Kitagawa, Takuji Iwase, Rie Horii, Futoshi Akiyama, Masami Arai
The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This case is significant and it verifies the importance of MRI screening in breast or ovarian cancer-free BRCA1/2 mutation carriers who do not exhibit positive mammographic or ultrasonographic findings.
January 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28079289/apocrine-metaplasia-found-at-mr-biopsy-is-there-something-to-be-learned
#14
Yiming Gao, Vandana Dialani, Carolynn DeBenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast lesions which underwent MR-guided biopsy, yielding ApoM on pathology analysis were included...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#15
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28067435/mr-imaging-findings-in-molecular-subtypes-of-breast-cancer-according-to-birads-system
#16
Lidia Navarro Vilar, Salvador Pascual Alandete Germán, Rosana Medina García, Esther Blanc García, Natalia Camarasa Lillo, José Vilar Samper
To evaluate magnetic resonance imaging (MRI) findings, according to Breast Imaging-Reporting and Data System (BI-RADS), and to relate them with molecular subtypes of breast cancer. The MRI findings were reviewed retrospectively in 201 women diagnosed of invasive breast cancer confirmed by surgery and were compared with the molecular subtypes. Following the BI-RADS, MRI findings included disease type, size, enhancement, morphology and contrast kinetics. In mass-like lesion types were studied shape, margin and enhancement, and in nonmass-like lesion types, distribution modifiers and internal enhancement...
January 9, 2017: Breast Journal
https://www.readbyqxmd.com/read/28066808/effect-of-mr-imaging-contrast-thresholds-on-prediction-of-neoadjuvant-chemotherapy-response-in-breast-cancer-subtypes-a-subgroup-analysis-of-the-acrin-6657-i-spy-1-trial
#17
Wen Li, Vignesh Arasu, David C Newitt, Ella F Jones, Lisa Wilmes, Jessica Gibbs, John Kornak, Bonnie N Joe, Laura J Esserman, Nola M Hylton
Functional tumor volume (FTV) measurements by dynamic contrast-enhanced magnetic resonance imaging can predict treatment outcomes for women receiving neoadjuvant chemotherapy for breast cancer. Here, we explore whether the contrast thresholds used to define FTV could be adjusted by breast cancer subtype to improve predictive performance. Absolute FTV and percent change in FTV (ΔFTV) at sequential time-points during treatment were calculated and investigated as predictors of pathologic complete response at surgery...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28055246/validation-of-a-semi-automated-technique-to-accurately-measure-abdominal-fat-distribution-using-ct-and-mri-for-clinical-risk-stratification
#18
Mohammed Abdul Waduud, Amal Sharaf, Iain Roy, Rosario Lopez-Gonzalez, Andrew Hart, David McGill, Giles Roditi, John Biddlestone
OBJECTIVES: A valid method for accurate quantification of abdominal fat distribution (AFD) using both computer tomography (CT) and magnetic resonance imaging (MRI) is described. This method will be primarily useful in the prospective risk stratification of patients undergoing reconstructive breast surgery. Secondary applications in many other clinical specialities are foreseen. METHODS: 15 sequential patients who had undergone breast reconstruction following both CT and MRI imaging (30 scans) were retrospectively identified at our single centre...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28050694/survival-prediction-using-temporal-muscle-thickness-measurements-on-cranial-magnetic-resonance-images-in-patients-with-newly-diagnosed-brain-metastases
#19
Julia Furtner, Anna S Berghoff, Omar M Albtoush, Ramona Woitek, Ulrika Asenbaum, Daniela Prayer, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Bernadette Aretin, Rupert Bartsch, Christoph C Zielinski, Veronika Schöpf, Matthias Preusser
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two independent cohorts of 188 breast cancer (BC) and 247 non-small cell lung cancer (NSCLC) patients (overall: 435 patients). RESULTS: Survival analysis using a Cox regression model showed a reduced risk of death by 19% with every additional millimetre of baseline TMT in the BC cohort and by 24% in the NSCLC cohort...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28048929/su-c-207b-04-automated-segmentation-of-pectoral-muscle-in-mr-images-of-dense-breasts
#20
E Verburg, S N de Waard, W B Veldhuis, C H van Gils, Kga Gilhuijs
PURPOSE: To develop and evaluate a fully automated method for segmentation of the pectoral muscle boundary in Magnetic Resonance Imaging (MRI) of dense breasts. METHODS: Segmentation of the pectoral muscle is an important part of automatic breast image analysis methods. Current methods for segmenting the pectoral muscle in breast MRI have difficulties delineating the muscle border correctly in breasts with a large proportion of fibroglandular tissue (i.e., dense breasts)...
June 2016: Medical Physics
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