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https://www.readbyqxmd.com/read/29219225/dce-mri-texture-analysis-with-tumor-subregion-partitioning-for-predicting-ki-67-status-of-estrogen-receptor-positive-breast-cancers
#1
Ming Fan, Hu Cheng, Peng Zhang, Xin Gao, Juan Zhang, Guoliang Shao, Lihua Li
BACKGROUND: Breast tumor heterogeneity is related to risk factors that lead to worse prognosis, yet such heterogeneity has not been well studied. PURPOSE: To predict the Ki-67 status of estrogen receptor (ER)-positive breast cancer patients via analysis of tumor heterogeneity with subgroup identification based on patterns of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). STUDY TYPE: Retrospective study. POPULATION: Seventy-seven breast cancer patients with ER-positive breast cancer were investigated, of whom 51 had low Ki-67 expression...
December 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29217399/feasibility-of-breast-mri-after-sentinel-procedure-for-breast-cancer-with-superparamagnetic-tracers
#2
Benedict Krischer, Serafino Forte, Tilo Niemann, Rahel A Kubik-Huch, Cornelia Leo
RATIONALE: The gold standard for detection of axillary sentinel lymph nodes uses injection of a radioisotope (99Tc Nanocoll). As an alternative to this method, a magnetometer detecting the superparamagnetic tracer Sienna+® can be applied for detection of sentinel lymph nodes. The goal of this study was to determine whether interpretation of breast MRI is impaired by Sienna+® tracer residues in the operated breast and axillary lymph nodes after a sentinel procedure using this tracer...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29206917/tunicamycin-induced-er-stress-in-breast-cancer-cells-neither-expresses-grp78-on-the-surface-nor-secretes-it-into-the-media
#3
Jesús E Serrano-Negrón, Zhenbo Zhang, Andrea P Rivera-Ruiz, Aditi Banerjee, Eva C Romero-Nutz, Neysharie Sánchez-Torres, Krishna Baksi, Dipak K Banerjee
GRP78 (an Mr 78 kDa calcium dependent glucose binding protein) located in ER lumen. It functions as ER chaperone and translocates proteins for glycosylation at the asparagine residue present in the sequon Asn-X-Ser/Thr. Paraffin sections from N-glycosylation inhibitor tunicamycin treated ER-/PR-/HER2+ (double negative) breast tumor in athymic nude mice exhibited reduced N-glycan but increased GRP78 expression. We have evaluated the effect of tunicamycin on cellular localization of GRP78 in metastatic human breast cancer cells MDA-MB-231 (ER-/PR-/HER2-)...
December 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/29195638/cause-specific-mortality-among-women-of-reproductive-age-results-from-a-population-based-study-in-an-iranian-community
#4
Javad Aghazadeh, Mohammad Esmaeil Motlagh, Rasool EntezarMahdi, Mohammad Eslami, Iraj Mohebbi, Hasan Yousefzadeh, Hamidreza Farrokh-Eslamlou
PURPOSE OF STUDY: This study was conducted to evaluate the levels, patterns, and causes of mortality among women of reproductive age in Northwestern Iran. METHODS: Deaths were determined for females resident in West Azerbaijan Province of Iran and who died between March 2013 to February 2014 using reproductive age mortality survey (RAMOS). Causes of death were ascertained by verbal autopsy (VA) and classified based on the International Classification of Diseases, tenth revision (ICD-10)...
December 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/29158836/a-laser-activated-biocompatible-theranostic-nanoagent-for-targeted-multimodal-imaging-and-photothermal-therapy
#5
Liming Deng, Xiaojun Cai, Danli Sheng, Yang Yang, Eric M Strohm, Zhigang Wang, Haitao Ran, Dong Wang, Yuanyi Zheng, Pan Li, Tingting Shang, Yi Ling, Fengjuan Wang, Yang Sun
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29155879/subtypes-of-breast-cancer-show-different-spatial-distributions-of-brain-metastases
#6
Sunghyon Kyeong, Yoon Jin Cha, Sung Gwe Ahn, Sang Hyun Suh, Eun Ju Son, Sung Jun Ahn
The aim of our study was to test the hypothesis that the spatial distribution of breast cancer brain metastases (BM) differ according to their biological subtypes. MR images of 100 patients with BM from primary breast cancer were retrospectively reviewed. Patients were divided according to the biological subtype of the primary tumor, (triple-negative: 24, HER2 positive: 48, luminal: 28). All images marked with BMs were standardized to the human brain MRI atlas provided by the Montreal Neurological Institute 152 database...
2017: PloS One
https://www.readbyqxmd.com/read/29152563/integrated-radiomic-framework-for-breast-cancer-and-tumor-biology-using-advanced-machine-learning-and-multiparametric-mri
#7
Vishwa S Parekh, Michael A Jacobs
Radiomics deals with the high throughput extraction of quantitative textural information from radiological images that not visually perceivable by radiologists. However, the biological correlation between radiomic features and different tissues of interest has not been established. To that end, we present the radiomic feature mapping framework to generate radiomic MRI texture image representations called the radiomic feature maps (RFM) and correlate the RFMs with quantitative texture values, breast tissue biology using quantitative MRI and classify benign from malignant tumors...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29148579/a-step-by-step-review-on-patient-specific-biomechanical-finite-element-models-for-breast-mri-to-x-ray-mammography-registration
#8
REVIEW
Eloy García, Yago Diez, Oliver Diaz, Xavier Lladó, Robert Martí, Joan Martí, Arnau Oliver
Breast magnetic resonance imaging (MRI) and X-ray mammography are two image modalities widely used for the early detection and diagnosis of breast diseases in women. The combination of these modalities leads to a more accurate diagnosis and treatment of breast diseases. The aim of this paper is to review the registration between breast MRI and X-ray mammographic images using patient-specific finite element-based biomechanical models. Specifically, a biomechanical model is obtained from the patient's MRI volume and is subsequently used to mimic the mammographic acquisition...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29144507/the-fragile-x-mental-retardation-protein-regulates-tumor-invasiveness-related-pathways-in-melanoma-cells
#9
Francesca Zalfa, Vincenzo Panasiti, Simone Carotti, Maria Zingariello, Giuseppe Perrone, Laura Sancillo, Laura Pacini, Flavie Luciani, Vincenzo Roberti, Silvia D'Amico, Rosa Coppola, Simona Osella Abate, Rosa Alba Rana, Anastasia De Luca, Mark Fiers, Valentina Melocchi, Fabrizio Bianchi, Maria Giulia Farace, Tilmann Achsel, Jean-Christophe Marine, Sergio Morini, Claudia Bagni
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer. Here we show that FMRP is overexpressed in human melanoma with high Breslow thickness and high Clark level. Furthermore, meta-analysis of the TCGA melanoma data revealed that high levels of FMRP expression correlate significantly with metastatic tumor tissues, risk of relapsing and disease-free survival...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29120811/magnetic-resonance-mr-features-in-triple-negative-breast-cancer-tnbc-vs-receptor-positive-cancer-ntnbc
#10
Giulia Angelini, Carolina Marini, Chiara Iacconi, Dionisia Mazzotta, Monica Moretti, Eugenia Picano, Riccardo Morganti
Few reports in literature describe triple negative breast cancer (TNBC) imaging findings. Aim of the study is to determine MR-features of TNBC compared to receptor positive cancer (nTNBC). From May 2014 to May 2015, we retrospectively enrolled 31 consecutive patients with histological diagnosis of TNBC and a control group of 31 consecutive nTNBC observed in the same period, out of 602 cancer, diagnosed in our department in the same year. Histopathological analysis and MR-features of TNBC (31 patients) were compared to nTNBC (31 patients)...
October 27, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29119195/clinics-in-diagnostic-imaging-180-ductal-carcinoma-in-situ-dcis
#11
Eu Jin Tan, Tammy Hui Lin Moey, Preetha Madhukumar, Lester Chee Hao Leong
A 26-year-old woman presented with a slow-growing right breast lump. Excision biopsy of the lump showed invasive ductal carcinoma with adjacent ductal carcinoma in situ (DCIS). Preoperative imaging was performed to assess the extent of disease. Magnetic resonance (MR) imaging of the breasts showed an area of clustered ring enhancement deep to the biopsy site, which was representative of residual DCIS. DCIS is a common noninvasive malignancy that manifests as a primary breast tumour or in association with other lesions...
October 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29114617/two-and-a-half-year-clinical-experience-with-the-world-s-first-magnetic-resonance-image-guided-radiation-therapy-system
#12
Benjamin W Fischer-Valuck, Lauren Henke, Olga Green, Rojano Kashani, Sahaja Acharya, Jeffrey D Bradley, Clifford G Robinson, Maria Thomas, Imran Zoberi, Wade Thorstad, Hiram Gay, Jiayi Huang, Michael Roach, Vivian Rodriguez, Lakshmi Santanam, Harold Li, Hua Li, Jessika Contreras, Thomas Mazur, Dennis Hallahan, Jeffrey R Olsen, Parag Parikh, Sasa Mutic, Jeff Michalski
Purpose: Magnetic resonance image guided radiation therapy (MR-IGRT) has been used at our institution since 2014. We report on more than 2 years of clinical experience in treating patients with the world's first MR-IGRT system. Methods and materials: A clinical service was opened for MR-IGRT in January 2014 with an MR-IGRT system consisting of a split 0.35T magnetic resonance scanner that straddles a ring gantry with 3 multileaf collimator-equipped (60)Co heads...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29108344/diffusion-weighted-mr-imaging-in-prediction-of-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer
#13
Xue-Ying Hu, Ying Li, Guan-Qiao Jin, Shao-Lv Lai, Xiang-Yang Huang, Dan-Ke Su
This study aims to evaluate the potential of apparent diffusion coefficient (ADC) derived from diffusion-weighted MR imaging for predicting the treatment response to neoadjuvant chemotherapy (NACT) in patients with breast cancer. Magnetic resonance imaging was performed prior to NACT and after two cycles of NACT. The correlation between mean ADCpre values, mean ADCpost values, changes in ADC values and changes in tumor diameters after NACT was examined using Spearman rank correlation. A total of 164 breast cancers were enrolled in this study...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103325/myofibrillogenesis-regulator-1-mr-1-a-potential-therapeutic-target-for-cancer-and-pnkd
#14
Junxia Wang, Wuli Zhao, Hong Liu, Hongwei He, Rongguang Shao
Human myofibrillogenesis regulator 1 (MR-1) is a functional gene also known as paroxysmal nonkinesigenic dyskinesia (PNKD). It is localised on human chromosome 2q35 and three different isomers, MR-1L, MR-1M and MR-1S, are formed by alternative splicing. MR-1S promotes cardiac hypertrophy and is closely related to cancer. MR-1S is overexpressed in haematologic and solid malignancies, such as hepatoma, breast cancer and chronic myelogenous leukaemia. MR-1S causes disordered cell differentiation, initiates malignant transformation and accelerates metastasis...
November 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29101636/lyp-1-conjugated-nanoparticles-for-magnetic-resonance-imaging-of-triple-negative-breast-cancer
#15
Abedelnasser Abulrob, Slavisa Corluka, Barbara Blasiak, B Gino Falonne, Dragana Ponjevic, John Matyas, Boguslaw Tomanek
PURPOSE: Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, or Her2/neu. Both diagnosis and treatment of TNBC remain a clinical challenge. LyP-1 is a cyclic 9 amino acid peptide that can bind to breast cancer cells. The goal of this study was to design and characterize LyP-1 conjugated to fluorescent iron oxide nanoparticles (LyP-1-Fe3O4-Cy5.5) as a contrast agent for improved and specific magnetic resonance imaging (MRI) in a preclinical model of TNBC...
November 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#16
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095673/intravoxel-incoherent-motion-and-quantitative-non-gaussian-diffusion-mr-imaging-evaluation-of-the-diagnostic-and-prognostic-value-of-several-markers-of-malignant-and-benign-breast-lesions
#17
Mami Iima, Masako Kataoka, Shotaro Kanao, Natsuko Onishi, Makiko Kawai, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
Purpose To investigate the performance of integrated approaches that combined intravoxel incoherent motion (IVIM) and non-Gaussian diffusion parameters compared with the Breast Imaging and Reporting Data System (BI-RADS) to establish multiparameter thresholds scores or probabilities by using Bayesian analysis to distinguish malignant from benign breast lesions and their correlation with molecular prognostic factors. Materials and Methods Between May 2013 and March 2015, 411 patients were prospectively enrolled and 199 patients (allocated to training [n = 99] and validation [n = 100] sets) were included in this study...
November 2, 2017: Radiology
https://www.readbyqxmd.com/read/29090067/magnetic-iron-oxide-nanoparticles-as-t2-mr-imaging-contrast-agent-for-detection-of-breast-cancer-mcf-7-cell
#18
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Mohammad Suhaimi Jaafar, Amin Malik Shah Abdul Majid, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
BACKGROUND: Advances of nanotechnology have led to the development of nano-materials with both potential diagnostic and therapeutic applications. Among them, Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) have received particular attention. Modified EDC coupling fraction was used to fabricate the SPION-C595 as an MR imaging contrast agent for breast cancer detection in early stages. METHODS: Nanoprobe characterization was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDAX), and Photon Correlation Spectroscopy (PCS)...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29089348/circulating-vitamin-d-concentration-and-risk-of-seven-cancers-mendelian-randomisation-study
#19
Vasiliki I Dimitrakopoulou, Konstantinos K Tsilidis, Philip C Haycock, Niki L Dimou, Kawthar Al-Dabhani, Richard M Martin, Sarah J Lewis, Marc J Gunter, Alison Mondul, Irene M Shui, Evropi Theodoratou, Katharina Nimptsch, Sara Lindström, Demetrius Albanes, Tilman Kühn, Timothy J Key, Ruth C Travis, Karani Santhanakrishnan Vimaleswaran, Peter Kraft, Brandon L Pierce, Joellen M Schildkraut
Objective To determine if circulating concentrations of vitamin D are causally associated with risk of cancer.Design Mendelian randomisation study.Setting Large genetic epidemiology networks (the Genetic Associations and Mechanisms in Oncology (GAME-ON), the Genetic and Epidemiology of Colorectal Cancer Consortium (GECCO), and the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortiums, and the MR-Base platform).Participants 70 563 cases of cancer (22 898 prostate cancer, 15 748 breast cancer, 12 537 lung cancer, 11 488 colorectal cancer, 4369 ovarian cancer, 1896 pancreatic cancer, and 1627 neuroblastoma) and 84 418 controls...
October 31, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29082597/magnetic-resonance-molecular-imaging-of-metastatic-breast-cancer-by-targeting-extradomain-b-fibronectin-in-the-tumor-microenvironment
#20
Zheng Han, Han Cheng, Jenny G Parvani, Zhuxian Zhou, Zheng-Rong Lu
PURPOSE: Non-invasive early accurate detection of malignant breast cancer is paramount to the clinical management of the life-threatening disease. Here, we aim to test a small peptide targeted MRI contrast agent, ZD2-Gd(HP-DO3A), specific to an oncoprotein, extradomain-B fibronectin (EDB-FN), in the tumor microenvironment for MR molecular imaging of breast cancer. METHOD: EDB-FN expression in 4T1 and MDA-MB-231 cancers was analyzed with quantitative real-time PCR and western blot...
October 29, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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