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Breast mr

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https://www.readbyqxmd.com/read/28643383/multiecho-pseudo-golden-angle-stack-of-stars-thermometry-with-high-spatial-and-temporal-resolution-using-k-space-weighted-image-contrast
#1
Bryant T Svedin, Allison Payne, Bradley D Bolster, Dennis L Parker
PURPOSE: Implement and evaluate a 3D MRI method to measure temperature changes with high spatial and temporal resolution and large field of view. METHODS: A multiecho pseudo-golden angle stack-of-stars (SOS) sequence with k-space weighted image contrast (KWIC) reconstruction was implemented to simultaneously measure multiple quantities, including temperature, initial signal magnitude M(0), transverse relaxation time ( T2*), and water/fat images. Respiration artifacts were corrected using self-navigation...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28643295/fat-suppression-techniques-for-breast-mri-dixon-versus-spectral-fat-saturation-for-3d-t1-weighted-at-3%C3%A2-t
#2
Anastasia Kalovidouri, Natacha Firmenich, Benedicte M A Delattre, Marlise Picarra, Christoph D Becker, Xavier Montet, Diomidis Botsikas
OBJECTIVE: To compare two fat suppression techniques used for 3D T1-weighted sequence in breast MRI (magnetic resonance imaging), namely Dixon versus spectral fat saturation (fat sat). MATERIALS AND METHODS: All breast MRI examinations performed in a Philips 3 T unit between March 2013 and October 2015 including either a Dixon or a fat sat sequence were retrospectively analyzed. The examinations were subjectively evaluated by two independent experienced readers in a scale of 5 for overall quality of fat suppression, homogeneity of fat suppression, definition of anatomic structures and focal lesions, diagnostic confidence for axillary and internal mammary regions and the presence of artifacts, 1 corresponding to excellent and 5 to non-diagnostic quality...
June 22, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28624749/prevalence-and-clinical-significance-of-incidental-extra-mammary-findings-in-breast-magnetic-resonance-imaging-a-retrospective-study-of-1070-patients
#3
Wieland Staab, Jan Menke, Christian Sohns, Susanne Wienbeck, Lukas Bauer, Johannes Tammo Kowallick, Frank Konietschke, Thorsten Derlin, Joachim Lotz, Jan Martin Sohns
PURPOSE: The purpose of this study was to analyze the prevalence of extra-mammary findings in magnetic resonance imaging (MRI). MATERIALS AND METHODS: Data from 1070 consecutive breast MRI studies was analyzed. MR-BI-RADS (Breast Imaging Reporting and Data System) was used to classify the risk category. RESULTS: According to MR-BI-RADS, 915 (85.5%) of 1070 women were classified into MR-BI-RADS categories 1-3, and 155 (14.5%) into MR-BI-RADS categories 4-5...
June 10, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28624020/a-new-method-to-reduce-false-positive-results-in-breast-mri-by-evaluation-of-multiple-spectral-regions-in-proton-mr-spectroscopy
#4
Paola Clauser, Magda Marcon, Matthias Dietzel, Pascal A T Baltzer
OBJECTIVES: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of (1)H-MRS of the breast and reduce false positive findings. METHODS: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T scanner were eligible for this IRB-approved prospective study. Suspicious enhancing lesions ≥8mm underwent single-voxel point-resolved (1)H-MRS (PRESS, TR=2000ms, TE=272ms)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622420/technical-note-comparison-of-megavoltage-dual-energy-and-single-energy-ct-based-%C3%AE-maps-for-a-4-channel-breast-coil-in-pet-mri
#5
John C Patrick, R Terry Thompson, Aaron So, John Butler, David Faul, Robert Z Stodilka, Slav Yartsev, Frank S Prato, Stewart Gaede
PURPOSE: The purpose of this study was to describe and evaluate methods for calculating a megavoltage computed tomography (MVCT) derived MR hardware attenuation map (μ-map) and dual-energy CT (DECT) for 511 keV photons. METHODS: Phantom measurements were acquired on a whole-body hybrid PET/MRI system, using a four-channel receive-only MR radiofrequency (RF) breast coil. Two acquisitions were performed: with the phantoms positioned in the four-channel RF breast coil, and without the breast coil...
June 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28617548/bioinformatic-analysis-of-prognostic-value-of-arap3-in-breast-cancer-and-the-associated-signaling-pathways
#6
J-J Han, B-R Du, C-H Zhang
OBJECTIVE: In this study, we tried to pool previous annotated genomic data to assess the association between ARAP3 expression and metastatic relapse (MR) risk in patients with breast cancer. Moreover, we also investigated the signaling pathways in which ARAP3 might be involved in breast cancer. MATERIALS AND METHODS: The raw microarray data (GDS5666) that compared gene transcriptional profiles of 4T1 derived lung-aggressive explant and primary tumor explant were reanalyzed to identify the dysregulated genes...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617547/mastl-is-a-potential-poor-prognostic-indicator-in-er-breast-cancer
#7
B-Z Zhuge, B-R Du, X-L Meng, Y-Q Zhang
OBJECTIVE: In this study, we aimed to explore prognostic value of MASTL (microtubule-associated serine/threonine kinase-like) in breast cancer patients on the basis of ER status and molecular subtypes. MATERIALS AND METHODS: The raw microarray data (GDS5666) of 4T1 derived bone-aggressive explant and primary tumor explant were reanalyzed to identify the dysregulated genes. To pool previous annotated genomic data that assessed the association between MASTL expression and metastatic relapse (MR) risk, MR-free survival, any event (AE, defined as any relapse or death) risk, and AE-free survival in breast cancer patients, a meta-analysis was performed by bc-GenExMiner 4...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#8
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28609204/surveillance-of-women-with-the-brca1-or-brca2-mutation-by-using-biannual-automated-breast-us-mr-imaging-and-mammography
#9
Jan C M van Zelst, Roel D M Mus, Gwendolyn Woldringh, Matthieu J C M Rutten, Peter Bult, Suzan Vreemann, Mathijn de Jong, Nico Karssemeijer, Nicoline Hoogerbrugge, Ritse M Mann
Purpose To evaluate a multimodal surveillance regimen including yearly full-field digital (FFD) mammography, dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging, and biannual automated breast (AB) ultrasonography (US) in women with BRCA1 and BRCA2 mutations. Materials and Methods This prospective multicenter trial enrolled 296 carriers of the BRCA mutation (153 BRCA1 and 128 BRCA2 carriers, and 15 women with first-degree untested relatives) between September 2010 and November 2012, with follow-up until November 2015...
June 13, 2017: Radiology
https://www.readbyqxmd.com/read/28609163/imaging-appearance-and-clinical-impact-of-preoperative-breast-mri-in-pregnancy-associated-breast-cancer
#10
Kelly S Myers, Lauren A Green, Lizza Lebron, Elizabeth A Morris
OBJECTIVE: The purpose of this study is to describe the imaging features of pregnancy-associated breast cancer (PABC) on breast MRI and to consider the impact of preoperative MRI on patient management. MATERIALS AND METHODS: A retrospective review of medical records from January 1994 to May 2014 identified 183 women who presented with a new diagnosis of breast cancer during pregnancy or within 1 year postpartum. MR images were available for 53 of these patients, all of whom were included in the study...
June 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28608119/breast-specific-sensuality-and-sexual-function-in-cancer-survivorship-does-surgical-modality-matter
#11
Jennifer S Gass, Michaela Onstad, Sarah Pesek, Kristin Rojas, Sara Fogarty, Ashley Stuckey, Christina Raker, Don S Dizon
PURPOSE: More early-staged breast cancer patients are choosing mastectomy. No studies have addressed breast-specific sensuality (BSS), defined as the breast's role during intimacy. We explored BSS among women undergoing lumpectomy (L), mastectomy alone (M), or with reconstruction (MR) and analyzed the association of surgical modality with sexual function. METHODS: Women undergoing breast cancer surgery between 2000 and 2013 were eligible for survey using investigator-generated questions and the Female Sexual Function Index (FSFI)...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28600647/hybrid-18-f-fdg-pet-mri-might-improve-locoregional-staging-of-breast-cancer-patients-prior-to-neoadjuvant-chemotherapy
#12
Briete Goorts, Stefan Vöö, Thiemo J A van Nijnatten, Loes F S Kooreman, Maaike de Boer, Kristien B M I Keymeulen, Romy Aarnoutse, Joachim E Wildberger, Felix M Mottaghy, Marc B I Lobbes, Marjolein L Smidt
PURPOSE: Our purpose in this study was to assess the added clinical value of hybrid (18)F-FDG-PET/MRI compared to conventional imaging for locoregional staging in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). METHODS: In this prospective study, primary invasive cT2-4 N0 or cT1-4 N+ breast cancer patients undergoing NAC were included. A PET/MRI breast protocol was performed before treatment. MR images were evaluated by a breast radiologist, blinded for PET images...
June 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28586291/evaluation-of-the-utility-of-screening-mammography-for-high-risk-women-undergoing-screening-breast-mr-imaging
#13
Glen Lo, Anabel M Scaranelo, Hana Aboras, Sandeep Ghai, Supriya Kulkarni, Rachel Fleming, Karina Bukhanov, Pavel Crystal
Purpose To evaluate the value of mammography in detecting breast cancer in high-risk women undergoing screening breast magnetic resonance (MR) imaging. Materials and Methods An ethics-approved, retrospective review of prospective databases was performed to identify outcomes of 3934 screening studies (1977 screening MR imaging examinations and 1957 screening mammograms) performed between January 2012 and July 2014 in 1249 high-risk women. Performance measures including recall and cancer detection rates, sensitivity, specificity, and positive predictive values were calculated for both mammography and MR imaging...
June 6, 2017: Radiology
https://www.readbyqxmd.com/read/28582633/performance-benchmarks-for-screening-breast-mr-imaging-in-community-practice
#14
Janie M Lee, Laura Ichikawa, Elizabeth Valencia, Diana L Miglioretti, Karen Wernli, Diana S M Buist, Karla Kerlikowske, Louise M Henderson, Brian L Sprague, Tracy Onega, Garth H Rauscher, Constance D Lehman
Purpose To compare screening magnetic resonance (MR) imaging performance in the Breast Cancer Surveillance Consortium (BCSC) with Breast Imaging Reporting and Data System (BI-RADS) benchmarks. Materials and Methods This study was approved by the institutional review board and compliant with HIPAA and included BCSC screening MR examinations collected between 2005 and 2013 from 5343 women (8387 MR examinations) linked to regional Surveillance, Epidemiology, and End Results program registries, state tumor registries, and pathologic information databases that identified breast cancer cases and tumor characteristics...
June 5, 2017: Radiology
https://www.readbyqxmd.com/read/28579430/cry2-is-suppressed-by-foxm1-mediated-promoter-hypermethylation-in-breast-cancer
#15
Lingling Liu, Hong Shen, Yang Wang
Loss of CRY2 confers aggressive phenotypes to breast cancer. However, the mechanism of its downregulation and its prognostic value in breast cancer are still not clear. Our data mining in TCGA breast cancer cohort (TCGA-BRCA) showed that the luminal A subtype of breast cancer had the highest CRY2 expression, while the basal-like subtype had the lowest CRY2 expression. The ER+ group had significantly higher CRY2 expression than the ER- group. Demethylation treatment using 5-AZA-dC significantly restored CRY2 expression in MDA-MB-231 and BT549 cells...
June 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28579267/preliminary-results-of-a-simplified-breast-mri-protocol-to-characterize-breast-lesions-comparison-with-a-full-diagnostic-protocol-and-a-review-of-the-current-literature
#16
Valeria Romeo, Renato Cuocolo, Raffaele Liuzzi, Albina Riccardi, Antonello Accurso, Alessandra Acquaviva, Roberta Buonocore, Massimo Imbriaco
RATIONALE AND OBJECTIVES: This study aimed to investigate whether a simplified breast magnetic resonance imaging (MRI) protocol consisting of a localizer, one precontrast sequence, and three time-point postcontrast sequences (at 28 seconds, 84 seconds and 252 seconds after the contrast agent administration) is suitable for the characterization of breast lesions as compared to a full diagnostic protocol (FDP). This study also aimed to review the current literature concerning abbreviated breast MRI protocols and offer an alternative protocol...
June 1, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28567547/breast-mr-imaging-for-the-assessment-of-residual-disease-following-initial-surgery-for-breast-cancer-with-positive-margins
#17
Julia Krammer, Elissa R Price, Maxine S Jochelson, Elizabeth Watson, Melissa P Murray, Stefan O Schoenberg, Elizabeth A Morris
OBJECTIVES: To determine the accuracy of post-operative MR in predicting residual disease in women with positive margins, emphasizing the size thresholds at which residual disease can be confidently identified. METHODS: This IRB-approved HIPAA-compliant retrospective study included 175 patients with MR after positive margins following initial surgery for breast cancer. Two expert readers independently re-evaluated MR images for evidence of residual disease at the surgical cavity and multifocal/multicentric disease...
May 31, 2017: European Radiology
https://www.readbyqxmd.com/read/28558007/the-clinical-significance-of-accompanying-nme-on-preoperative-mr-imaging-in-breast-cancer-patients
#18
Hye Mi Gweon, Joon Jeong, Eun Ju Son, Ji Hyun Youk, Jeong-Ah Kim, Kyung Hee Ko
PURPOSE: To investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance. METHODS: Between January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size...
2017: PloS One
https://www.readbyqxmd.com/read/28550025/30-years-of-the-mineralocorticoid-receptor-mineralocorticoid-receptor-null-mice-informing-cell-type-specific-roles
#19
REVIEW
Timothy J Cole, Morag J Young
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1-2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28541897/capacitive-micro-machined-ultrasound-transducers-for-interstitial-high-intensity-ultrasound-therapies
#20
W Apoutou N'Djin, Bjoern Gerold, Jeremy Vion, Michael Canney, An Nguyen-Dinh, Alexandre Carpentier, Jean-Yves Chapelon
Capacitive Micro-machined Ultrasound Transducers (CMUTs) exhibit several potential advantages over conventional piezo technologies for use in therapeutic ultrasound devices, including: ease of miniaturization and integration with electronics, broad bandwidth (>several MHz), and compatibility with magnetic resonance imaging (MRI). In this work, the electro-acoustic performance of CMUTs designed for interstitial high intensity contact ultrasound (HICU) applications was evaluated and the feasibility of generating ultrasound-induced heating and thermal destruction of biological tissues was studied...
May 24, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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