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Recurrent Respiratory Papillomatosis

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https://www.readbyqxmd.com/read/28231366/comparison-of-cidofovir-and-the-measles-mumps-and-rubella-vaccine-in-the-treatment-of-recurrent-respiratory-papillomatosis
#1
Ryan Kent Meacham, Jerome W Thompson
We conducted a retrospective study of the use of cidofovir and the measles, mumps, and rubella (MMR) vaccineas adjunctive treatments to lesion debridement in patients with recurrent respiratory papillomatosis (RRP). Our study population was made up of 15 children-7 boys and 8 girls, aged 1 to 16 years at diagnosis (mean: 6.2)-with pathologically confirmed RRP who had been followed for at least 1 year. In addition to demographic data, we compiled information on disease severity, the type of adjunctive treatment administered to each patient, the frequency of debridements, the length of observation, and remission rates...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28208177/feasibility-and-associated-limitations-of-office-based-laryngeal-surgery-using-carbon-dioxide-lasers
#2
Hao-Chun Hu, Shu-Yi Lin, Yi-Ting Hung, Shyue-Yih Chang
Importance: There are few reports evaluating awake, office-based carbon dioxide (CO2) laser surgery for laryngeal lesions. To date, this study was the largest reported case series of office-based laryngeal surgery by fiber delivery CO2 laser. Office-based laryngeal surgical procedures have become increasingly popular. Technical problems and treatment outcomes associated with the use of a CO2 laser for office-based laryngeal surgery have yet to be fully addressed. Objectives: To discuss a single institution's clinical experience with office-based CO2 laser laryngeal surgery and the feasibility and limitations associated with this procedure...
February 16, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28193306/quality-of-life-of-young-patients-with-recurrent-respiratory-papillomatosis
#3
B B Montaño-Velázquez, J Nolasco-Renero, J E Parada-Bañuelos, F Garcia-Vázquez, S Flores-Medina, C S García-Romero, K Jáuregui-Renaud
OBJECTIVE: To assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media. METHOD: Participants and their parents completed the Pediatric Quality of Life Inventory 4.0. RESULTS: Patients with recurrent respiratory papillomatosis and their parents reported lower quality of life than healthy subjects (p < 0...
February 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28171734/imiquimod-injection-to-rabbit-vocal-folds
#4
Stephanie E Teng, Gregory R Dion, Danielle N Sin, Nao Hiwatashi, Peter A Benedict, Milan R Amin, Ryan C Branski
Objective Given the recalcitrant nature of recurrent respiratory papillomatosis, targeted therapies to reduce disease burden are fundamental to improved patient care paradigms. We seek to demonstrate the safety of imiquimod injection into vocal fold mucosa by evaluating the degree of laryngeal edema, histopathologic changes to vocal fold structure, and serologic interferon α (IFNα) levels following injection. Study Design Preclinical. Setting Academic institution. Subjects and Methods Six New Zealand White rabbits underwent unilateral injection of 100 µg of sterile imiquimod (1 µg/µL), with 100 µL of normal saline injected into the contralateral vocal fold...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28109479/therapeutic-use-of-the-hpv-vaccine-in-recurrent-respiratory-papillomatosis-a-case-report
#5
Christopher Sullivan, Stuart Curtis, Jason Mouzakes
Recurrent Respiratory Papillomatosis (RRP) is a condition characterized by recurring squamous papillomas in the aerodigestive tract due to Human Papilloma Virus (HPV) infection. Treatment includes surgical debridement of the lesions often with adjuvant therapy. A newer adjuvant agent being tested is the HPV vaccine. The case report includes a child with RRP who underwent 10 surgeries in a year with an average inter-surgical interval (ISI) of 46 days. The patient then received the scheduled regimen of 3 doses of 9 valent HPV vaccine...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28072562/a-systematic-review
#6
Sarah Drejet, Stacey Halum, Matthew Brigger, Elaine Skopelja, Noah P Parker
Objectives (1) To systematically identify studies evaluating the use of intralesional cidofovir or bevacizumab as an adjunct in adult recurrent respiratory papillomatosis, determine disease severity and functional outcomes, and assess study quality. (2) To compare outcomes between the 2 adjuncts. Data Sources Ovid Medline, EMBASE, Scopus, and Clinical-Trials.gov . Review Methods Data sources were systematically searched. A priori inclusion and exclusion criteria were instituted. Quality was evaluated with the Newcastle-Ottawa Quality Assessment Scale...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27863633/intersurgical-interval-increased-with-use-of-quadrivalent-human-papillomavirus-vaccine-gardasil-in-a-pediatric-patient-with-recurrent-respiratory-papillomatosis-a-case-report
#7
Maraya M Baumanis, Charles A Elmaraghy
This is a case of a 4 year old female with recalcitrant recurrent respiratory papillomatosis with decreasing intersurgical interval that had improvement in clinical course after administration of the quadrivalent HPV vaccine.
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27861969/quality-of-life-of-patients-with-recurrent-respiratory-papillomatosis
#8
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy. STUDY DESIGN: Prospective cross-sectional questionnaire research. METHODS: Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27821867/impaired-t-cell-dependent-humoral-immune-response-associated-with-juvenile-onset-recurrent-respiratory-papillomatosis-progression
#9
Xunyao Wu, Guoliang Wang, Xi Chen, Jie Zhang, Jing Zhao, Jun Wang, Yang Xiao, Jun Tai, Shengcai Wang, Guixiang Wang, Hua Wang, Lina Bai, Jingang Gui, Xin Ni
Whether humoral immunity plays a role in HPV type 6 or 11 virus-mediated Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP) remains unknown. In the present study, serum total IgG level in 44 JORRP patients was significantly decreased compared with that in 40 healthy controls. Moreover, expanded CD3(-)CD19(+) B cells with down-regulation of CD23, CD40, HLA-DR and up-regulation of CD86 expression were found in the peripheral blood of JORRP patients. Flow cytometry analysis of B-cell compartment showed that the frequency of both CD19(+)CD27(hi) plasma cells and CD19(+)CD27(+) memory B cells were decreased in JORRP patients...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27759910/laryngopharyngeal-reflux-and-herpes-simplex-virus-type-2-are-possible-risk-factors-for-adult-onset-recurrent-respiratory-papillomatosis-prospective-case-control-study
#10
M Formánek, D Jančatová, P Komínek, P Matoušek, K Zeleník
OBJECTIVE: The human papillomavirus (HPV) causes recurrent respiratory papillomatosis (RRP). Although HPV prevalence is high, the incidence of papillomatosis is low. Thus, factors other than HPV infection probably contribute to RRP. This study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (ChT) and whether laryngopharyngeal reflux (LPR) occurs in this group of patients more often. DESIGN: Prospective case-control study...
October 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27637752/clinical-features-and-surgical-treatment-for-chinese-juvenile-onset-current-respiratory-papillomatosis-jorrp
#11
Weixin Cui, Wen Xu, Qingwen Yang, Rong Hu
Juvenile onset current respiratory papillomatosis (JORRP), which is the commonest benign laryngeal disease in children, has not been well investigated. This study aimed at further evaluating the clinical features and surgery for such children with JORRP. Patients diagnosed as JORRP in our department from January 2011 to June 2014 were enrolled, and the demographic and clinical data were collected. All the patients were followed up after surgery, and the recurrences were recorded. A total of 124 patients were included and categorized into low recurrence (<4/year, n = 97) and high recurrence (≥4/year, n = 27) groups based on the recurrence at diagnosis, respectively...
February 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27600632/validation-of-the-distress-thermometer-and-problem-list-in-patients-with-recurrent-respiratory-papillomatosis
#12
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
Objective There is no specific clinical tool for physicians to detect psychosocial and physical distress or health care need in patients with recurrent respiratory papillomatosis (RRP). The main aim of this study is to validate the RRP-adapted Distress Thermometer and Problem List (DT&PL). Study Design Prospective cross-sectional questionnaire research. Setting Academic tertiary care medical centers in Groningen, Netherlands, and Helsinki, Finland. Subjects and Methods Ninety-one juvenile- and adult-onset RRP patients participated from the departments of otorhinolaryngology-head and neck surgery of the University Medical Center Groningen, Netherlands, and Helsinki University Hospital, Finland...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27515839/multidimensional-vocal-assessment-after-laser-treatment-for-recurrent-respiratory-papillomatosis
#13
Takeyuki Kono, Haruna Yabe, Kosuke Uno, Koichiro Saito, Kaoru Ogawa
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a benign epithelial tumor that exhibits a high frequency of recurrence. This study assesses the vocal function after laser treatment for RRP, particularly in relation to the frequency of surgery. STUDY DESIGN: Retrospective study. METHODS: Thirty RRP patients who underwent laser surgery that controlled the tumor were included. Preoperative and postoperative Grade, Roughness, Breathiness, Asthenia, and Strain Scale, videostroboscopic findings, aerodynamic and acoustic parameters, and self-assessment questionnaires were measured and compared with an age- and sex-matched control group...
August 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27500575/-the-association-of-the-severe-clinical-course-of-respiratory-papillomatosis-with-certain-hla-dq-alleles
#14
O M Kolesnikova
We undertook the analysis of genetic polymorphism of the HLADQA1 and DQB1 genes in the patients presenting with recurrent respiratory papillomatosis (n=21) with the use of the multiprimer polymerase chain reaction. The results of the study give evidence that the identification of DQ 2.5 and DQ 7.5 haplotypes encoded by the DQA1 *0501, DQB1 *0201, DQA1 *0505, and DQB1 *0301 alleles as well as the carriage of type 16 human papilloma virus (HPV) in combination with these haplotypes in the patients with recurrent respiratory papillomatosis can be used for the prognostication of the severity of this disease...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27349143/lung-parenchymal-involvement-in-juvenile-recurrent-respiratory%C3%A2-papillomatosis
#15
Ajay Lall, Kamal Gera, Jaya Kumar
No abstract text is available yet for this article.
September 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27339455/laryngeal-inflammatory-myofibroblastic-tumor-imt-a-case-report-and-review-of-the-literature
#16
Sok Yan Tay, Abhilash Balakrishnan
BACKGROUND: This case report is interesting as cases of children with laryngeal inflammatory myofibroblastic tumor are not common and previously had been presented as isolated case reports. This is the first case report in Asia describing a laryngeal inflammatory myofibroblastic tumor and its removal using an endoscopic approach. CASE PRESENTATION: Our patient is a 12-year-old Malay girl from Singapore who presented with hoarseness without respiratory distress. The initial impression was that of a granuloma or a papilloma...
June 23, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27242951/office-based-management-of-recurrent-respiratory-papilloma
#17
Kevin M Motz, Alexander T Hillel
This review will highlight the indications and benefits of office-based therapy for recurrent respiratory papillomatosis (RRP) and discuss the utilization of photo-dynamic lasers and adjuvant medical therapy in office-based settings. Office-based management of RRP allows for more timely interventions, is preferred by the majority of patients, and negates the risk of general anesthesia. Current literature argues for the utilization of KTP laser over CO2 laser for office-based treatment of RRP. Medical therapies for RRP are limited, but agents such as bevacizumab are promising and have been shown to reduce disease burden...
June 2016: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/27234949/-anogenital-warts-in-a-major-venereology-clinic-centro-de-sa%C3%A3%C2%BAde-da-lapa-lisbon-2008-to-2014
#18
Ana Gameiro, João Alves, Irene Santo, Jacinta Azevedo
INTRODUCTION: Human papillomavirus infection is the most common sexual transmitted infection in the world, being associated with different diseases, namely anogenital warts, recurrent respiratory papillomatosis and anal, cervical, and oropharyngeal cancers. Among sexually active people, approximately 1% has anogenital warts, 90% of cases resulting from genotypes 6 and 11. MATERIAL AND METHODS: Patients diagnosed with first episode of anogenital warts from 2008 to 2014 in Lisbon's major venereology clinic were identified, and characterized according to sex, sexual orientation, age, warts location, and number of sexual partners...
February 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27217191/impact-of-hpv-vaccination-on-anogenital-warts-and-respiratory-papillomatosis
#19
Zoon Wangu, Katherine K Hsu
Human papillomavirus (HPV), the most common sexually transmitted infection in the US and worldwide, can cause cancers, anogenital warts (AGW), and recurrent respiratory papillomatosis (RRP) in men, women, and children. Global incidence of AGW ranges from 160-289 cases per 100,000 person-years and peaks in young men and women in the third decade of life. RRP has an estimated incidence of 3 per 1 million person-years in children. Pre-licensure trial efficacy, modeling and time-trend ecological studies have shown a significant short-term impact of 4vHPV vaccine...
June 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27208548/prevalence-and-management-of-recurrent-respiratory-papillomatosis-rrp-in-the-uk-cross-sectional-study
#20
A J Donne, K Keltie, H Cole, A J Sims, H Patrick, S Powell
OBJECTIVES: To estimate the number of patients with recurrent respiratory papillomatosis currently managed in secondary and tertiary health care in the UK and the frequency of its treatment with radiofrequency cold ablation (Coblation(™) ). DESIGN: Cross-sectional survey of ENT consultants in the UK with validation using Hospital Episode Statistics (HES) inpatient data. SETTING: Online survey. PARTICIPANTS: ENT consultants in the UK...
February 2017: Clinical Otolaryngology
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