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https://www.readbyqxmd.com/read/29458214/effect-of-tetrahedral-dna-nanostructures-on-proliferation-and-osteo-odontogenic-differentiation-of-dental-pulp-stem-cells-via-activation-of-the-notch-signaling-pathway
#1
Mi Zhou, Nan-Xin Liu, Si-Rong Shi, Yong Li, Qi Zhang, Quan-Quan Ma, Tao-Ran Tian, Wen-Juan Ma, Xiao-Xiao Cai, Yun-Feng Lin
Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29457917/clinical-characteristics-and-long-term-prognosis-of-elderly-onset-crohn-s-disease
#2
Eun Mi Song, Nayoung Kim, Sun-Ho Lee, Kiju Chang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
OBJECTIVES: This study aimed to evaluate the clinical characteristics and clinical course of Asian elderly-onset Crohn's disease (EOCD) patients in a large well-defined cohort of South Korean IBD patients. MATERIALS AND METHODS: From the Asan inflammatory bowel disease registry, we identified 29 EOCD patients (diagnosed with CD in age of 60 years or over) out of 2989 CD patients (1.0%). After excluding two patients with unclear data, 27 EOCD were matched with 108 young-onset CD (YOCD) and 108 middle age-onset CD (MOCD) for the interval from symptom onset to diagnosis (±3 years) and follow-up duration (±3 years)...
February 19, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29457624/-coordinated-heart-failure-care-in-poland-towards-optimal-organisation-of-the-health-care-system
#3
Jadwiga Nessler, Adam Kozierkiewicz, Andrzej Gackowski, Piotr Ponikowski, Ewa Straburzynska-Migaj, Izabella Uchmanowicz, Piotr Hoffman, Krzysztof Chlebus, Grzegorz Gielerak, Mariusz Gąsior, Tomasz Grodzicki, Jakub Gierczyński, Piotr Jankowski, Jarosław Kaźmierczak, Jacek Legutko, Przemysław Leszek, Maciej Miłkowski, Grzegorz Opolski, Piotr Rozentryt, Adam Windak, Adam Witkowski, Mirosław J Wysocki, Andrzej Zapaśnik, Tomasz Zdrojewski
Heart failure has becoming an increasing medical, economic, and social problem globally. The prevalence of this syndrome is rising, and despite unequivocal positive effects of modern therapy, reduction of mortality has been achieved at the cost of more frequent hospitalisations. Unlike in many European countries, in Poland heart failure is usually recognised later, at a more advanced stage of the disease, leaving less time for ambulatory treatment and resulting in a high number of hospitalisations. The current paper presents the most important data regarding morbidity and mortality due to heart failure in Poland...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29457348/fixed-dose-vs-free-dose-combinations-for-the-management-of-hypertension-an-analysis-of-81-958-patients
#4
Peter Bramlage, Stefanie Schmidt, Helen Sims
Fixed-dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed-dose or free-dose (freeDC) ramipril/amlodipine (R/A) or candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients were prescribed R/A and 10 495 C/A. For both R/A and C/A, FDC patients were younger (both P < .001) and less comorbid. Prior MI (OR: 0.61 and 0.60), prior stroke (OR: 0.68 and 0.70) and CHD (OR: 0.68 and 0.64) were negatively associated with FDC use, whereas hyperlipidemia was positively associated (OR: 1...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29456706/comparison-of-single-and-triple-injection-methods-for-ultrasound-guided-interscalene-brachial-plexus-blockade
#5
Cun-Jin Wang, Ya-Li Ge, Ju Gao, Feng-Yun Long, Zhi-Hua Mi, Tian-Feng Huang, Xiang-Zhi Fang, Xiao-Ping Chen, Yu-Si Hua, Yang Zhang
Ultrasound-guided interscalene brachial plexus blockade (IBPB) has a relatively high success rate in shoulder surgery; however, whether multiple injections are superior to a single injection (SI) is currently unknown. In the present study, ultrasound-guided SI and triple-injection (TI) IBPBs were compared in a prospective randomized trial. A total of 111 patients undergoing arthroscopic shoulder surgery and presenting with an American Society of Anesthesiologists physical status grading of I-II were randomly allocated to receive IBPB with 15 ml of 1% ropivacaine as a SI or TI...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456702/application-of-pre-injection-of-dexmedetomidine-of-different-doses-in-pediatric-intravenous-general-anesthesia-without-tracheal-intubation
#6
Mi Zhou, Qiang Wang, Qiong Zhang, Yifei Liu, Leyun Zhan, Aihua Shu
This study observed the clinical efficacy of pre-injection of dexmedetomidine of different doses before surgery and the adverse reactions during the recovery period in pediatric intravenous general anesthesia without tracheal intubation. Pediatric patients who received general anesthesia without tracheal intubation before surgery from January 2016 to March 2017 were randomly divided into four groups (n=30), and were respectively treated with intravenous pump infusion of loaded dexmedetomidine of high-dose (2...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456666/microrna-125b-1-3p-mediates-intervertebral-disc-degeneration-in-rats-by-targeting-teashirt-zinc-finger-homeobox-3
#7
Xiaotong Meng, Yue Zhu, Lin Tao, Sichao Zhao, Shui Qiu
The present study aimed to investigate the association between Teashirt zinc finger homeobox 3 (TSHZ3) and the nucleus pulposus (NP) of intervertebral discs in rats. TSHZ3 was identified from the differentially expressed micro (mi)RNAs in the expression profile of GSE63492 by identifying the overlapped target genes of microRNA (miR)-125b-1-3p across different databases. TSHZ3 small interfering RNA (siRNA) and an miR-125b-1-3p inhibitor were used for gene silencing and gene silencing efficiency was assessed by reverse transcription-polymerase chain reaction...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456659/prmt1-rbm15-axis-regulates-megakaryocytic-differentiation-of-human-umbilical-cord-blood-cd34-cells
#8
Shuiling Jin, Yanfang Mi, Jing Song, Peipei Zhang, Yanyan Liu
Protein arginine methyltransferase 1 (PRMT1) serves pivotal roles in various cellular processes. However, its role in megakaryocytic differentiation has not been clearly reported. The aim of the present study was to explore the role of the PRMT-RNA binding motif protein 15 (RBM15) axis in human MK differentiation and the feasibility of targeting PRMT1 for leukemia treatment. In the present study, PRMT1 was overexpressed and the RBM15 protein was knocked down in human umbilical cord blood cluster of differentiation (CD)34+ cells and the cells were then cultured in megakaryocytic differentiation medium...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456549/global-dna-methylation-in-the-chestnut-blight-fungus-cryphonectria-parasitica-and-genome-wide-changes-in-dna-methylation-accompanied-with-sectorization
#9
Kum-Kang So, Yo-Han Ko, Jeesun Chun, Jyotiranjan Bal, Junhyun Jeon, Jung-Mi Kim, Jaeyoung Choi, Yong-Hwan Lee, Jin Hoe Huh, Dae-Hyuk Kim
Mutation in CpBck1 , an ortholog of the cell wall integrity mitogen-activated protein kinase kinase kinase (MAPKKK) of Saccharomyces cerevisiae , in the chestnut blight fungus Cryphonectria parasitica resulted in a sporadic sectorization as culture proceeded. The progeny from the sectored area maintained the characteristics of the sector, showing a massive morphogenetic change, including robust mycelial growth without differentiation. Epigenetic changes were investigated as the genetic mechanism underlying this sectorization...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29456526/ammonia-oxidizing-archaea-and-bacteria-differentially-contribute-to-ammonia-oxidation-in-sediments-from-adjacent-waters-of-rushan-bay-china
#10
Hui He, Yu Zhen, Tiezhu Mi, Lulu Fu, Zhigang Yu
Ammonia oxidation plays a significant role in the nitrogen cycle in marine sediments. Ammonia-oxidizing archaea (AOA) and bacteria (AOB) are the key contributors to ammonia oxidation, and their relative contribution to this process is one of the most important issues related to the nitrogen cycle in the ocean. In this study, the differential contributions of AOA and AOB to ammonia oxidation in surface sediments from adjacent waters of Rushan Bay were studied based on the ammonia monooxygenase ( amoA ) gene...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29456464/three-dimensional-multiscale-multistable-and-geometrically-diverse-microstructures-with-tunable-vibrational-dynamics-assembled-by-compressive-buckling
#11
Xin Ning, Heling Wang, Xinge Yu, Julio A N T Soares, Zheng Yan, Kewang Nan, Gabriel Velarde, Yeguang Xue, Rujie Sun, Qiyi Dong, Haiwen Luan, Chan Mi Lee, Aditya Chempakasseril, Mengdi Han, Yiqi Wang, Luming Li, Yonggang Huang, Yihui Zhang, John Rogers
Microelectromechanical systems remain an area of significant interest in fundamental and applied research due to their wide ranging applications. Most device designs, however, are largely two-dimensional and constrained to only a few simple geometries. Achieving tunable resonant frequencies or broad operational bandwidths requires complex components and/or fabrication processes. The work presented here reports unusual classes of three-dimensional (3D) micromechanical systems in the form of vibratory platforms assembled by controlled compressive buckling...
April 11, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29456111/methyllucidone-inhibits-stat3-activity-by-regulating-the-expression-of-the-protein-tyrosine-phosphatase-meg2-in-du145-prostate-carcinoma-cells
#12
Yena Jin, Young Hwan Kim, Jin Yong Park, Yu-Jin Lee, Hyun-Mi Oh, Sung-Kyu Choi, Dong Cho Han, Byoung-Mog Kwon
During the search for signal transducer and activator of transcription 3 (STAT3) inhibitors from natural products, methyllucidone, isolated from Lindera species (Lauraceae), was identified as a STAT3 inhibitor. Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Methyllucidone decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, Bcl-2, Mcl-1, and survivin...
February 8, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29455786/examination-of-the-appropriate-timing-of-reperfusion-therapy-for-recent-myocardial-infarction-a-japanese-single-center-retrospective-study
#13
Yukio Mizuguchi, Hiroki Shibutani, Sho Hashimoto, Takeshi Yamada, Norimasa Taniguchi, Shunsuke Nakajima, Tetsuya Hata, Akihiko Takahashi
BACKGROUND: The various guidelines clearly mention the treatment strategies for in patient of acute myocardial infarction (MI) presenting more than 24h from symptom onset (recent myocardial infarction, RMI). However, the appropriate timing of reperfusion for RMI is unclear. METHODS: We retrospectively evaluated 525 consecutive MI patients who underwent percutaneous coronary intervention (PCI) in our hospital between January 2008 and December 2012. RESULTS: Sixty RMI patients were more frequently associated with cardiac complications such as myocardial rupture (3...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455776/confronting-system-barriers-for-st-elevation-mi-in-low-and-middle-income-countries-with-a-focus-on-india
#14
Sameer Mehta, Christopher Granger, Cindy Lee Grines, Alice Jacobs, Timothy D Henry, Ivan Rokos, Alexandra Lansky, Andreas Baumbach, Roberto Botelho, Alexandra Ferre, Isaac Yepes, Roopa Salwan, Jamshed Dalal, Jitendra Makkar, Neeraj Bhalla, Sundeep Mishra, Vinod Vijan, Shirish Hiremath
Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455574/immune-responsive-resolvin-d1-programs-myocardial-infarction-induced-cardiorenal-syndrome-in-heart-failure
#15
Ganesh V Halade, Vasundhara Kain, Charles N Serhan
Resolvins are innate, immune responsive, bioactive mediators generated after myocardial infarction (MI) to resolve inflammation. The MI-induced bidirectional interaction between progressive left ventricle (LV) remodeling and kidney dysfunction is known to advance cardiorenal syndrome (CRS). Whether resolvins limit MI-induced cardiorenal inflammation is unclear. Thus, to define the role of exogenous resolvin D (RvD)-1 in post-MI CRS, we subjected 8-12-wk-old male C57BL/6 mice to coronary artery ligation. RvD1 was injected 3 h after MI...
February 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29455311/accelerated-molecular-breeding-of-a-novel-p-tgms-line-with-broad-spectrum-resistance-to-rice-blast-and-bacterial-blight-in-two-line-hybrid-rice
#16
Jiaming Mi, Dabing Yang, Yi Chen, Jiefeng Jiang, Haipeng Mou, Junbin Huang, Yidan Ouyang, Tongmin Mou
BACKGROUND: Breeding two-line hybrid rice with disease resistance is an effective approach to stabilize rice yield in commercial rice production of China. RESULTS: We improved the blast and bacterial blight resistance of Guangzhan63-4S, an elite photoperiod- and thermo-sensitive male sterile (P/TGMS) line widely used in two-line hybrid rice, by introducing the R genes Pi2 and Xa7 conferring resistance to rice blast and bacterial blight, respectively. Through the backcrossing and gene pyramiding breeding coupled with molecular marker-assisted selection, a new P/TGMS line Hua1228S carrying Pi2, Xa7, and tms5 was developed...
February 17, 2018: Rice
https://www.readbyqxmd.com/read/29455158/american-heart-association-s-life-s-simple-7-at-middle-age-and-prognosis-after-myocardial-infarction-in-later-life
#17
Yejin Mok, Yingying Sang, Shoshana H Ballew, Casey M Rebholz, Wayne D Rosamond, Gerardo Heiss, Aaron R Folsom, Josef Coresh, Kunihiro Matsushita
BACKGROUND: The American Heart Association recommends focusing on 7 health factors (Life's Simple 7) for primordial prevention of cardiovascular health. However, whether greater adherence to Life's Simple 7 in midlife improves prognosis after myocardial infarction (MI) in later life is unknown. METHODS AND RESULTS: In 1277 participants who developed MI during the ARIC (Atherosclerosis Risk in Communities) Study follow-up, a 14-point score of Life's Simple 7 was constructed according to the status (2 points for ideal, 1 point for intermediate, and 0 points for poor) of each of 7 factors (smoking, adiposity, physical activity, diet, total cholesterol, blood pressure, and fasting glucose) at baseline (1987-1989)...
February 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29455099/largely-enhanced-bioethanol-production-through-the-combined-use-of-lignin-modified-sugarcane-and-xylose-fermenting-yeast-strain
#18
Ja Kyong Ko, Je Hyeong Jung, Fredy Altpeter, Baskaran Kannan, Ha Eun Kim, Kyoung Heon Kim, Hal S Alper, Youngsoon Um, Sun-Mi Lee
The recalcitrant structure of lignocellulosic biomass is a major barrier in efficient biomass-to-ethanol bioconversion processes. The combination of feedstock engineering via modification in the lignin synthesis pathway of sugarcane and co-fermentation of xylose and glucose with a recombinant xylose utilizing yeast strain produced 148% more ethanol compared to that of the wild type biomass and control strain. The lignin reduced biomass led to a substantially increased release of fermentable sugars (glucose and xylose)...
February 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29455018/acute-massive-pulmonary-thromboembolism-treated-by-selective-catheter-directed-thrombolysis
#19
Feng Hai, Chen Xueming, Zhang Zhiwen, Li Chenyu, Fang Jie, Zhang Zhe, Lian Lishan, Zhu Renming, Yu Hongzhi, Liu Bin
OBJECTIVE: To evaluate the safety and efficacy of selective catheter-directed thrombolysis in treating acute massive pulmonary thromboembolism (AMPTE). MATERIALS AND METHODS: Twenty-six AMPTE patients were enrolled between March 2010 and March 2013. A Uni*Fuse infusion system was inserted into the main pulmonary artery thrombus. The thrombolytic regimen included an intraoperative bolus injection of 250,000 IU urokinase, followed by continuous thrombolytic infusion of 5,000IU/kg...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29454989/one-year-study-of-pm-2-5-in-xinxiang-city-north-china-seasonal-characteristics-climate-impact-and-source
#20
Jinglan Feng, Hao Yu, Kai Mi, Xianfa Su, Yi Li, Qilu Li, Jianhui Sun
This study was conducted in order to explore the seasonal characteristics, climate impact and source of PM2.5 in Xinxiang, China. Daily PM2.5 samples were collected at urban site from January to December in 2015. Average PM2.5 concentration was 100.6 ± 65.8 μg m-3 in Xinxiang, which was several times higher than China Ambient Air Quality Standards (GB3095-2012). Secondary inorganic aerosols (SIA) constituted 70% of the total ionic concentrations. The average concentration of SO4 2- was 6.4 ± 12.0 μg m-3 , which ranked the highest among the water-soluble ions analyzed...
February 15, 2018: Ecotoxicology and Environmental Safety
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