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Kyeong Seop Kim, Tae Ha Kim, Mi Ae Kim, Jung Sick Lee, Young Chang Sohn
Neuropeptides in the central nervous system regulate reproductive activities in vertebrates. Ala-Pro-Gly-Trp-NH2 (APGWamide), a neuromediator expressed in the neural ganglia of mollusks, controls sexual maturation and reproduction. To clarify the role of APGWamide in sexual behavior regulation and gamete cell maturation in mollusks, we cloned the cDNA of APGWamide precursor (Hdh-APGWamide) and examined the spatiotemporal expression of the transcript in the Pacific abalone Haliotis discus hannai. The 222-amino acid sequence of the precursor deduced from the cDNA sequence showed typical features of gastropod APGWamide precursors...
April 18, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Jong Jin Kim, Bosu Jeong, Yongin Cho, Mi-Hyang Kwon, Yong-Ho Lee, Uk Kang, Eun Seok Kang
Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects...
April 20, 2018: Scientific Reports
Chao Wang, Boya Zhang, Yu Lin, Yang Dong
AIM: To evaluate the role of adenovirus-mediated transduction human VEGF isoform 165 via direct myocardial injection in rats with an occluded circumflex coronary artery, and the possible underlying mechanism. METHODS: Sprague-Dawley rats were induced myocardial infarction (MI) with ligation of the left coronary artery. Rats were randomly divided into 4 groups: 1) the sham group; 2) the MI group; 3) the NS (normal saline) group and 4) the VEGF group. Direct myocardial injection of 0...
March 2018: Annals of Clinical and Laboratory Science
Peter Faries, Michael Jaff, Patrick Peeters, Yazan Khatib, David Roberts, Marc Bosiers, Rajesh Malik, Reid Ravin, John Rundback
OBJECTIVE: The DURABILITY Iliac clinical study evaluated the safety and effectiveness of two nitinol self-expanding stents for the treatment of atherosclerotic common and external iliac artery lesions up to 10 cm in length and >50% stenosis in subjects with Rutherford Classification peripheral arterial disease stages 2-4. METHODS: DURABILITY Iliac was a prospective, multicenter, core lab adjudicated, nonrandomized clinical study enrolling 75 subjects from 15 sites in the United States and Europe...
April 17, 2018: Annals of Vascular Surgery
Davood Najafi, Ramezan Ali Taheri, Abouzar Najafi, Abbas Abbas Rouhollahi, Manuel Alvarez-Rodriguez
The aim of this study was to compare the effectiveness of antioxidants including Achillea millefolium extract (AmE) (n0t1.5: 1.5, n0t3: 3 and n0t4.5: 4.5 mg/L) and AmE loaded in nano phytosome (n1t1.5: 1.5, n1t3: 3 and n1t4.5: 4.5 mg/L) in the freezing of Ross 308 rooster semen. Sperm motility (CASA), membrane integrity (HOS test), viability, total abnormality and enzymatic parameters (SOD, CAT and GPx) were assessed after thawing. AmE-loaded nano phytosome at a concentration of 3 mg/l resulted in significantly (P < 0...
April 17, 2018: Cryobiology
Dandan Yang, Luo Xu, Feifei Guo, Xiangrong Sun, Di Zhang, Mi Wang
Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (Arc) on feeding and glucose-responsive (GR) neurons physiology in a diet-induced obesity (DIO) and diet-induced obesity resistant (DR) rat model. Administration of orexin-A or cannabinoid receptor type-1 (CB1 R) antagonist AM251 altered the firing of GR neurons in the Arc...
April 6, 2018: Neuropeptides
Alexander S Kirpich, Miguel Ibarra, Oleksandr Moskalenko, Justin M Fear, Joseph Gerken, Xinlei Mi, Ali Ashrafi, Alison M Morse, Lauren M McIntyre
BACKGROUND: Metabolomics has the promise to transform the area of personalized medicine with the rapid development of high throughput technology for untargeted analysis of metabolites. Open access, easy to use, analytic tools that are broadly accessible to the biological community need to be developed. While technology used in metabolomics varies, most metabolomics studies have a set of features identified. Galaxy is an open access platform that enables scientists at all levels to interact with big data...
April 20, 2018: BMC Bioinformatics
Tiange Chen, Xiang Li, Jingang Yang, Jingyi Hu, Meilin Xu, Yong Qin, Yuejin Yang
The effects of treatment often vary over subpopulations characterized by baseline patient features. Detection of such treatment-subgroup interaction is of central importance to precision medicine and personalized care. In this paper, we propose an analytical framework for treatment-subgroup interactions detection and treatment effectiveness heterogeneity evaluation in a real-world data setting. Model-based recursive partitioning analysis (MOB) is used for subgroup identification, filter-based confounder selection and multivariate logistic regression are used for confounding reduction and treatment effectiveness assessment...
2018: Studies in Health Technology and Informatics
Seung Mi Lee, Min-Young Kim, Young Heon Kim
We investigated the effects of strain on the electronic structures of InAsxP1-x using quantum mechanical density functional theory calculations. The electronic band gap and electron effective mass decreased with the increase of the uniaxial tensile strain along the [0001] direction of wurtzite InAs0.75P0.25. Therefore, faster electron movements are expected. These theoretical results are in good agreement with the experimental measurements of InAs0.75P0.25 nanowire.
September 1, 2018: Journal of Nanoscience and Nanotechnology
Seung-Mi Lee, Jea-Yeon Kim, Jai-Won Byeon
Accidental failures and explosions of lithium-ion batteries have been reported in recent years. To determine the root causes and mechanisms of these failures from the perspective of material degradation, failure analysis was conducted for an intentionally shorted lithium-ion battery. The battery was subjected to electrical overcharging and mechanical pressing to simulate internal short-circuiting. After in situ measurement of the temperature increase during the short-circuiting of the electrodes, the disassembled battery components (i...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Mi Yeon Byun, Ji Sun Kim, Dae-Won Park, Man Sig Lee
The increasing role of catalysis by noble metals coupled with their high price requires the development of cheaper and more effective catalysts, e.g., highly dispersed supported catalyst. Herein, Pd supported on Al2O3 catalysts prepared by deposition-precipitation under different conditions were subjected to X-ray diffraction, N2-physisorption, NH3/CO2 temperature programmed desorption, CO-chemisorption, and field-emission transmission electron microscopy analyses, which revealed that the size and distribution of Pd particles were influenced by Al2O3 support type (particle size and phase transition) and preparation conditions (metal precursor type, pH value, and solution temperature)...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Tae Yang Son, Mi Ae Jeong, Sang Yong Nam
Amorphous fluoropolymers have been studied in the past few decades and received extensive attention due to their unique and useful properties. One of the remarkable properties of amorphous fluoropolymers is high fractional free volume (FFV), and they tend to retain large amounts of solvent inside their polymer chains. In this study, amorphous flouoropolymer membranes were employed to examine the influences of the residual solvent and drying condition on the thermal properties, gas permeation behavior, and structure change by the polymer chains...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Jinwoo Park, Mi Choi, Cheong-Soo Hwang
In this study, water-dispersible manganese (II) ion-doped ZnS nanocrystals (ZnS:Mn NCs) were synthesized by capping the surface with L-glycine molecules at various pH conditions. The UV-Visible and solution photoluminescence (PL) spectra showed broad peaks approximately at 330 and 590 nm, respectively. The calculated relative quantum efficiencies were in the range of 4.9∼5.8%, and the average particle sizes measured from the HR-TEM images were about 8 nm. Moreover, the surface charges of the corresponding ZnS:Mn-Gly NCs were determined by the electrophoretic method as: (-)14...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Ali M Allahdina, Paul F Stetson, Susan Vitale, Wai T Wong, Emily Y Chew, Fredrick L Ferris Iii, Paul A Sieving, Catherine Cukras
Purpose: As optical coherence tomography (OCT) minimum intensity (MI) analysis provides a quantitative assessment of changes in the outer nuclear layer (ONL), we evaluated the ability of OCT-MI analysis to detect hydroxychloroquine toxicity. Methods: Fifty-seven predominantly female participants (91.2% female; mean age, 55.7 ± 10.4 years; mean time on hydroxychloroquine, 15.0 ± 7.5 years) were enrolled in a case-control study and categorized into affected (i.e...
April 1, 2018: Investigative Ophthalmology & Visual Science
Sean L Zheng, Alistair J Roddick, Rochan Aghar-Jaffar, Matthew J Shun-Shin, Darrel Francis, Nick Oliver, Karim Meeran
Importance: The comparative clinical efficacy of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors for treatment of type 2 diabetes is unknown. Objective: To compare the efficacies of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality and cardiovascular end points using network meta-analysis. Data Sources: MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, and published meta-analyses from inception through October 11, 2017...
April 17, 2018: JAMA: the Journal of the American Medical Association
Mi Kyung Kim
No abstract text is available yet for this article.
April 2018: Diabetes & Metabolism Journal
Young Jin Choi, Hae Rin Oh, Jae Won Oh, Kyu Rang Kim, Mi Jin Kim, Baek Jo Kim, Won Gi Baek
Although atmospheric carbon dioxide (CO₂) has no apparent direct effect on human health, it does have direct effects on plants. The present study evaluated the influence of increased CO₂ levels on the concentration of allergens from common ragweed pollen by setting up a chamber study to model future air conditions and a field study to evaluate current air conditions. For the chamber study, we established 20 ragweed plants in an open-top chamber under different CO₂ levels (380-400, 500-520, 600-620, and 1,000-1,100 parts per million [ppm])...
May 2018: Allergy, Asthma & Immunology Research
Sang Heon Kim, Ji Yong Moon, Jae Hyun Lee, Ga Young Ban, Sujeong Kim, Mi Ae Kim, Joo Hee Kim, Min Hye Kim, Chan Sun Park, So Young Park, Hyouk Soo Kwon, Jae Woo Kwon, Jae Woo Jung, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, You Sook Cho, Kwang Ha Yoo, Yeon Mok Oh, Byung Jae Lee, An Soo Jang, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon
PURPOSE: Severe asthma and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) are difficult to control and are often associated with poor clinical outcomes. However, much is not understood regarding the diagnosis and treatment of severe asthma and ACOS. To evaluate the current perceptions of severe asthma and COPD among asthma and COPD specialists, we designed an e-mail and internet-based questionnaire survey. METHODS: Subjects were selected based on clinical specialty from among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Academy of Tuberculosis and Respiratory Diseases...
May 2018: Allergy, Asthma & Immunology Research
Ling Chen, Xiongze Zhang, Bing Liu, Lan Mi, Feng Wen
IMPORTANCE: Fundus aging and its imaging features BACKGROUND: To characterize the demographic and multimodal-imaging features of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA). DESIGN: A hospital-based retrospective study. PARTICIPANTS: 875 normal fundi fellow eyes from 875 patients underwent indocyanine green angiography (ICGA), fluorescence angiography (FA), autofluorescence (AF) and spectral-domain optical coherence tomography (OCT)...
April 19, 2018: Clinical & Experimental Ophthalmology
Eun Joo Kim, Mi-Seon Kong, Sang Geon Park, Sheri J Y Mizumori, Jeiwon Cho, Jeansok J Kim
Predation is considered a major selective pressure in the evolution of fear, but the neurophysiology of predator-induced fear is unknown. We simultaneously recorded lateral amygdala (LA) and prelimbic (PL) area neuronal activities as rats exited a safe nest to search for food in an open space before, during, and after encountering a "predator" robot programmed to surge from afar. Distinct populations of LA neurons transiently increased spiking as rats either advanced or fled the robot, whereas PL neurons showed longer-lasting spike trains that preceded and persisted beyond LA activity...
April 2018: Science Advances
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