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https://www.readbyqxmd.com/read/28350812/sports-related-sudden-cardiac-deaths-in-the-young-population-of-switzerland
#1
Babken Asatryan, Cristina Vital, Christoph Kellerhals, Argelia Medeiros-Domingo, Christoph Gräni, Lukas D Trachsel, Christian M Schmied, Ardan M Saguner, Prisca Eser, David Herzig, Stephan Bolliger, Katarzyna Michaud, Matthias Wilhelm
BACKGROUND: In Switzerland, ECG screening was first recommended for national squad athletes in 1998. Since 2001 it has become mandatory in selected high-risk professional sports. Its impact on the rates of sports-related sudden cardiac death (SCD) is unknown. OBJECTIVE: We aimed to study the incidence, causes and time trends of sports-related SCD in comparison to SCD unrelated to exercise in Switzerland. METHODS: We reviewed all forensic reports of SCDs of the German-speaking region of Switzerland in the age group of 10 to 39 years, occurring between 1999 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28350713/sex-specific-maximum-predicted-heart-rate-and-its-prognosis-for-mortality-and-mi
#2
Haitham M Ahmed, Mouaz H Al-Mallah, Steven J Keteyian, Clinton A Brawner, Jonathan K Ehrman, Di Zhao, Eliseo Guallar, Michael J Blaha, Erin D Michos
PURPOSE: Maximum predicted heart rate (MPHR) is traditionally calculated by (220-Age). However, this formula's validity has been questioned in women. The purpose of this study was to derive sex-specific formulas for MPHR in a clinical population, and compare their prognostic significance to the traditional formula. METHODS: This was a retrospective cohort of adults referred for exercise treadmill testing (ETT) between 1991 and 2009. Peak heart rate versus age was plotted by sex, and linear regression analysis was used to derive sex-specific MPHR formulas...
March 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28350523/comparison-of-micro-ct-and-cone-beam-ct-on-the-feasibility-of-assessing-mandibular-trabecular-structures-in-mandibular-condyle
#3
Xin Liang, Zuyan Zhang, Jianping Gu, Zhihui Wang, Bart Vandenberghe, Reinhilde Jacobs, Jie Yang, Guowu Ma, Haibin Ling, Xuchen Ma
OBJECTIVES: To evaluate the accuracy of Cone-beam CT (CBCT) in assessing trabecular structures Methods: Two human mandibles were scanned by micro-CT (Skyscan 1173 high energy spiral scan micro-CT, Skyscan NV, Kontich, Belgium) and CBCT(3D Accuitomo 170, Morita Japan). The CBCT images were reconstructed in 0.5mm and 1 mm thickness. The condylar images were selected for registration. A parallel algorithm for histogram computation was introduced to perform the registration. Mutual information (MI) value was used to evaluate the match between the images obtained from micro-CT and CBCT...
March 28, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28350453/diazaphenoxazines-and-diazaphenothiazines-synthesis-of-the-correct-isomers-reveals-they-are-highly-reactive-radical-trapping%C3%A2-antioxidants
#4
Evan A Haidasz, Derek A Pratt
The preparation of 2,4-diazaphenothiazines and 2,4-diazaphenoxazines via a copper-catalyzed intramolecular amination is described. Literature approaches which utilize easily accessed (2'-aminophenyl) 4-pyri(mi)dyl sulfides undergo a Smiles rearrangement that gives rise to the 1,3-diaza derivatives instead, confirmed by X-ray crystallography. Inversion of the polarity of the cyclization avoids the rearrangement and affords the desired products. Preliminary kinetic studies suggest that 2,4-diazaphenothiazines and diazaphenoxazines, but not the 1,3-diaza isomers, are remarkably potent radical-trapping antioxidants...
March 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28346838/hiv-1-transmission-networks-across-south-korea
#5
Mi Young Ahn, Joel O Wertheim, Woo Joo Kim, Shin-Woo Kim, Jin Soo Lee, Hea Won Ann, Yongduk Jeon, Jin Young Ahn, Je Eun Song, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, In Young Jung, Moo Hyun Kim, Wooyoung Jeong, Su Jin Jeong, Nam Su Ku, June Myung Kim, Davey M Smith, Jun Yong Choi
Molecular epidemiology can help clarify the properties and dynamics of HIV-1 transmission networks in both global and regional scales. We studied 143 HIV-1-infected individuals recruited from four medical centers of three cities in South Korea between April 2013 and May 2014. HIV-1 env V3 sequence data were generated (337-793 bp) and analyzed using a pairwise distance-based clustering approach to infer putative transmission networks. Participants whose viruses were ≤2.0% divergent according to Tamura-Nei 93 genetic distance were defined as clustering...
March 27, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28346488/comparison-of-chest-ct-findings-in-nontuberculous-mycobacterial-diseases-vs-mycobacterium-tuberculosis-lung-disease-in-hiv-negative-patients-with-cavities
#6
Cherry Kim, So Hee Park, Sang Young Oh, Sung-Soo Kim, Kyung-Wook Jo, Tae Sun Shim, Mi Young Kim
OBJECTIVES: This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS: We retrospectively reviewed 128 NTM disease patients (79 males and 49 females) with cavities in chest CT, matched for age and gender with 128 TB patients in the same period. Sputum cultures of all patients were positive for pathogens. Two independent chest radiologists evaluated the characteristics of the largest cavity and related factors...
2017: PloS One
https://www.readbyqxmd.com/read/28346422/the-metastatic-suppressor-ndrg1-inhibits-emt-migration-and-invasion-through-interaction-and-promotion-of-caveolin-1-ubiquitylation-in-human-colorectal-cancer-cells
#7
L Mi, F Zhu, X Yang, J Lu, Y Zheng, Q Zhao, X Wen, A Lu, M Wang, M Zheng, J Ji, J Sun
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells...
March 27, 2017: Oncogene
https://www.readbyqxmd.com/read/28346285/effect-of-early-revascularization-on-outcomes-in-diabetic-patients-with-stable-ischemic-heart-disease-and-previous-myocardial-infarction-in-the-bypass-angioplasty-investigation-2-diabetes-trial
#8
Matthew J Chung, Eric Novak, David L Brown
BACKGROUND: Survivors of a myocardial infarction (MI) are at a considerable risk of developing further cardiovascular events, including recurrent MI, heart failure, stroke, and death. Patients with type 2 diabetes mellitus and stable ischemic heart disease (SIHD) have worse outcomes than their nondiabetic counterparts, and those with previous MI may be at particularly high risk. Yet, little is known about the effect of adding early revascularization to intensive medical therapy in this high-risk group...
March 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28346278/effects-of-myopic-orthokeratology-on-visual-performance-and-optical-quality
#9
Guihua Liu, Zhi Chen, Feng Xue, Jing Li, Mi Tian, Xingtao Zhou, Ruihua Wei
OBJECTIVES: To analyze the changes in visual performance and optical quality after orthokeratology (ortho-k) treatment and its correlation with the magnitude of lens decentration and the diameter of treatment zone (TxZ). METHODS: A prospective study was conducted in 27 eyes of 27 patients wearing ortho-k contact lens. Area under log contrast sensitivity function (AULCSF), modulation transfer function cutoff values (MTFcutoff), Strehl ratio (SR), and objective scattering index (OSI) were measured and compared before and 1 month after ortho-k lens treatment...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28346240/combined-oral-medroxyprogesterone-levonorgestrel-intrauterine-system-treatment-for-women-with-grade-2-stage-ia-endometrial-cancer
#10
Ji Young Hwang, Da Hee Kim, Hyo Sook Bae, Mi-La Kim, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Eunah Shin, Mi Kyoung Kim
OBJECTIVE: The aim of this study was to evaluate the oncologic and pregnancy outcomes of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment in young women with grade 2-differentiated stage IA endometrial adenocarcinoma who wish to preserve fertility. METHODS: We retrospectively reviewed the medical records of patients with grade 2 stage IA endometrial adenocarcinoma who had received fertility-sparing treatment at CHA Gangnam Medical Center between 2011 and 2015...
March 24, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28346105/high-throughput-clonogenic-analysis-of-3d-cultured-patient-derived-cells-with-a-micropillar-and-microwell-chip
#11
Dong Woo Lee, Sang-Yun Lee, Lily Park, Mi-Sun Kang, Myoung-Hee Kim, Il Doh, Gyu Ha Ryu, Do-Hyun Nam
A high-throughput clonogenic assay with a micropillar-microwell chip platform is proposed by using the colony area of glioblastoma multiforme (GBM) patient-derived cells (PDCs) from colony images. Unlike conventional cell lines, PDCs from the tumor are composed of heterogeneous cell populations, and some clonogenic populations form colonies during culture while the rest die off or remain unchanged, thus causing the diverse distribution of colony size. Therefore, area-based analysis of the total colonies is not sufficient to estimate total cell viability or toxicity responses...
February 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345953/reperfusion-ventricular-arrhythmia-bursts-identify-larger-infarct-size-in-spite-of-optimal-epicardial-and-microvascular-reperfusion-using-cardiac-magnetic-resonance-imaging
#12
Kirian van der Weg, Wichert J Kuijt, Sebastiaan Cam Bekkers, Jan Gp Tijssen, Cynthia L Green, Miguel E Lemmert, Mitchell W Krucoff, Anton Pm Gorgels
AIMS: Ventricular arrhythmia (VA) bursts following recanalisation in acute ST-elevation myocardial infarction (STEMI) are related to larger infarct size (IS). Inadequate microvascular reperfusion, as determined by microvascular obstruction (MVO) using cardiac magnetic resonance imaging (CMR), is also known to be associated with larger IS. This study aimed to test the hypothesis that VA bursts identify larger infarct size in spite of optimal microvascular reperfusion. METHODS: All 65 STEMI patients from the Maastricht ST elevation (MAST) study with brisk epicardial flow (TIMI 3), complete ST recovery post-percutaneous coronary intervention and early CMR were included...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28345856/instantaneous-pulsed-light-cross-linking-of-a-polymer-gate-dielectric-for-flexible-organic-thin-film-transistors
#13
Soo Jin Kim, Mi Jang, Hee Yeon Yang, Jinhan Cho, Ho Sun Lim, Hoichang Yang, Jung Ah Lim
We report the instantaneous pulsed-light cross-linking of polymer gate dielectrics on a flexible substrate by using intensely pulsed white light (IPWL) irradiation. Irradiation with IPWL for only 1.8 s of a poly(4-vinylphenol) (PVP) thin film with the cross-linking agent poly(melamine-co-formaldehyde) (PMF) deposited on a plastic substrate was found to yield fully cross-linked PVP films. It was confirmed that the IPWL-cross-linked PVP films have smooth pinhole-free surfaces and exhibit a low leakage current density, organic solvent resistance, and good compatibility with organic semiconductor, and that they can be used as replacements for typical PVP dielectrics that are cross-linked with time and energy intensive thermal heating processes...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345853/single-crystal-like-perovskite-for-high-performance-solar-cells-using-effective-merged-annealing-method
#14
Yanliang Liu, Insoo Shin, In-Wook Hwang, Seungmin Kim, Jihoon Lee, Mi-Sun Yang, Yun Kyung Jung, Jae-Won Jang, Jung Hyun Jeong, Sung Heum Park, Kwang Ho Kim
We report a simple, low cost, and quite effective method for achieving single-crystal-like CH3NH3PbI3 perovskite leading to a significant enhancement in the performance and stability of inverted planar perovskite solar cells (IPSCs). By employing a merged annealing method during the fabrication of an IPSC for preparing the perovskite CH3NH3PbI3 film, we remarkably increase the crystallinity of the CH3NH3PbI3 film and enhance the device performance and stability. An IPSC with the indium tin oxide/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)/CH3NH3PbI3 (active layer)/ [6,6]-phenyl-C61-butyric acid methyl ester/Al structure was fabricated using the merged annealing method and exhibited significantly enhanced performance with a high power conversion efficiency of 18...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345315/the-role-of-macrophage-lipophagy-in-reverse-cholesterol-transport
#15
REVIEW
Se Jin Jeong, Mi Ni Lee, Goo Taeg Oh
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345242/multi-electron-oxidation-of-anthracene-derivatives-by-nonheme-manganese-iv-oxo-complexes
#16
Namita Sharma, Jieun Jung, Yong-Min Lee, Mi Sook Seo, Wonwoo Nam, Shunichi Fukuzumi
Six-electron oxidation of anthracene to anthraquinone by a nonheme Mn(IV)-oxo complex, [(Bn-TPEN)MnIV(O)]2+, proceeds via the rate-determining electron transfer from anthracene to [(Bn-TPEN)MnIV(O)]2+, followed by subsequent fast oxidation reactions to give anthraquinone. The reduced Mn(II) complex ([(Bn-TPEN)MnII]2+) is oxidized by [(Bn-TPEN)MnIV(O)]2+ rapidly to produce the μ-oxo dimer ([(Bn-TPEN)MnIII-O-MnIII(Bn-TPEN)]4+). The oxygen atoms of the anthraquinone product were found to derive from the manganese-oxo species by the 18O labelling experiments...
March 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28345154/outcomes-in-post-myocardial-infarction-patients-similar-to-those-of-the-pegasus-timi-54-trial-a-cohort-study-in-the-french-national-claims-database
#17
Patrick Blin, Caroline Dureau-Pournin, Régis Lassalle, Jérémy Jové, Florence Thomas-Delecourt, Cécile Droz-Perroteau, Nicolas Danchin, Nicholas Moore
AIMS: The present study aims to describe real-life outcomes in stable post-myocardial infarction (MI) patients similar to those in the PEGASUS-TIMI 54 trial (PEGASUS), which found long-term benefits of ticagrelor in patients with a history of MI. METHODS: One-year event-free post-MI patients were identified in the French claims database representative 1/97 sample (2005-2010) and followed up to 3 years. A PEGASUS-like (PL) population included patients with age ≥ 65 years, or age ≥50 and diabetes, renal dysfunction or prior MI, without stroke, end-stage renal failure or oral anticoagulation...
March 26, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28345153/the-functional-architectures-of-addition-and-subtraction-network-discovery-using-fmri-and-dcm
#18
Yang Yang, Ning Zhong, Karl Friston, Kazuyuki Imamura, Shengfu Lu, Mi Li, Haiyan Zhou, Haiyuan Wang, Kuncheng Li, Bin Hu
The neuronal mechanisms underlying arithmetic calculations are not well understood but the differences between mental addition and subtraction could be particularly revealing. Using fMRI and dynamic causal modeling (DCM), this study aimed to identify the distinct neuronal architectures engaged by the cognitive processes of simple addition and subtraction. Our results revealed significantly greater activation during subtraction in regions along the dorsal pathway, including the left inferior frontal gyrus (IFG), middle portion of dorsolateral prefrontal cortex (mDLPFC), and supplementary motor area (SMA), compared with addition...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28345145/air-pollution-and-short-term-clinical-outcomes-of-patients-with-acute-myocardial-infarction
#19
Min Woo Lee, Byoung Geol Choi, Suhng Wook Kim, Seung-Woon Rha, Min Suk Shim, Dae Jin Kim, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong
1.Ambient air pollution is well-known to be a serious risk factor for cardiovascular diseases, stroke, and death. However, the association between air pollutants (AP) exposure and short-term clinical outcomes in acute myocardial infarction (AMI) patients (pts) is not well elucidated yet. 2.In the present study, 37,880 AMI pts were enrolled finally from October 2005 to December 2013 in a nationwide large-scale, prospective, multicenter Korea AMI registry (KAMIR registry; http://www.kamir.or.kr). We obtained data on AP (e...
March 27, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28344980/discordance-in-investigator-reported-and-adjudicated-sudden-death-in-tiospir
#20
Robert A Wise, Peter R Kowey, George Austen, Achim Mueller, Norbert Metzdorf, Andy Fowler, Lorcan P McGarvey
Accurate and consistent determination of cause of death is challenging in chronic obstructive pulmonary disease (COPD) patients. TIOSPIR (N=17 135) compared the safety and efficacy of tiotropium Respimat 5/2.5 µg with HandiHaler 18 µg in COPD patients. All-cause mortality was a primary end-point. A mortality adjudication committee (MAC) assessed all deaths. We aimed to investigate causes of discordance in investigator-reported and MAC-adjudicated causes of death and their impact on results, especially cardiac and sudden death...
January 2017: ERJ Open Research
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