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JOURNAL ARTICLE
Genshan Zhang, Wei Jiang, Fangxun He, Jie Fu, Xiangshang Xu, Xuelai Luo, Zhixin Cao
BACKGROUND: PNPLA3 is a promising target for the treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease. ARO-PNPLA3 is a drug that efficiently lowers PNPLA3 expression in hepatocytes at the mRNA level, resulting in a significant reduction in liver fat in Phase I clinical trials. However, the long-term effects and potential side effects of ARO-PNPLA3 are not well understood. METHODS: We conducted a two-sample, two-step Mendelian randomization (MR) analysis to investigate the association between PNPLA3 inhibition and 10 cardiovascular diseases (CVDs), as well as the role of lipid traits as mediators...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
#2
JOURNAL ARTICLE
Mi Zhang, Kairong Du, Yun Lu, Wei Wu, Huan Yan, Qiaoli Jiang, Liang Liu, Xiaobo Feng
Pregabalin is the first-line treatment for neuropathic pain. Cases of cutaneous hypersensitivity reactions caused by pregabalin generally occur within 2 weeks of initiating medication. We report a rare case of a delayed cutaneous hypersensitivity reaction caused by pregabalin, which was confirmed by a drug provocation test. A 72-year-old man with severe herpes zoster neuralgia developed maculopapular drug eruption covering 80% to 90% of his total body surface area after 40 days of combined multidrug analgesia...
April 2024: Journal of International Medical Research
#3
JOURNAL ARTICLE
Charlotte E Greer, Janice Chew-Harris, Philip D Adamson, Chris J Pemberton, John W Pickering, Anna P Pilbrow, Chris M Frampton, Richard W Troughton, Robert N Doughty, A Mark Richards
BACKGROUND: Growth differentiation factor-15 (GDF-15) has been shown to be associated with adverse clinical outcomes in patients after an acute coronary syndrome when measured soon after an event. Although dynamic in the acute phase after myocardial injury, GDF-15 has been shown to remain stable during convalescence. In this study, we aimed to assess the value of GDF-15 as a long-term prognostic marker for clinical outcomes when measured in the convalescent phase following an acute coronary syndrome...
April 18, 2024: Journal of Applied Laboratory Medicine
#4
JOURNAL ARTICLE
Duy Cong Tran, Linh Hoang Gia Le, Truc Thanh Thai, Sy Van Hoang, Minh Duc Do, Binh Quang Truong
The pathogenesis and prognosis of patients with acute myocardial infarction (AMI) may be influenced by both genetic and environmental factors. Findings on the relationship of polymorphisms in various genes encoding the renin-angiotensin-aldosterone system with coronary artery lesions and mortality in AMI patients are inconsistent. The aim of this study was to determine whether the AGTR1 A1166C genetic polymorphism affects coronary artery lesions and 1-year mortality in post-AMI patients. Patients with their first AMI admitted to Cho Ray Hospital, Vietnam, from January 2020 to August 2021 were enrolled in this prospective clinical study...
2024: PloS One
#5
JOURNAL ARTICLE
Zurui Ao, Xiaomei Hu, Shengli Tao, Xie Hu, Guoquan Wang, Mingjia Li, Fang Wang, Litang Hu, Xiuyu Liang, Jingfeng Xiao, Asadilla Yusup, Wenhua Qi, Qinwei Ran, Jiayi Fang, Jinfeng Chang, Zhenzhong Zeng, Yongshuo Fu, Baolin Xue, Ping Wang, Kefei Zhao, Le Li, Wenkai Li, Yumei Li, Mi Jiang, Yuanhe Yang, Haihua Shen, Xia Zhao, Yue Shi, Bo Wu, Zhengbing Yan, Mengjia Wang, Yanjun Su, Tianyu Hu, Qin Ma, Hao Bai, Lijun Wang, Ziyan Yang, Yuhao Feng, Danhua Zhang, Erhan Huang, Jiamin Pan, Huiying Ye, Chen Yang, Yanwei Qin, Chenqi He, Yanpei Guo, Kai Cheng, Yu Ren, Haitao Yang, Chengyang Zheng, Jiangling Zhu, Shaopeng Wang, Chengjun Ji, Biao Zhu, Hongyan Liu, Zhiyao Tang, Zhiheng Wang, Shuqing Zhao, Yanhong Tang, Hanfa Xing, Qinghua Guo, Yu Liu, Jingyun Fang
China's massive wave of urbanization may be threatened by land subsidence. Using a spaceborne synthetic aperture radar interferometry technique, we provided a systematic assessment of land subsidence in all of China's major cities from 2015 to 2022. Of the examined urban lands, 45% are subsiding faster than 3 millimeters per year, and 16% are subsiding faster than 10 millimeters per year, affecting 29 and 7% of the urban population, respectively. The subsidence appears to be associated with a range of factors such as groundwater withdrawal and the weight of buildings...
April 19, 2024: Science
#6
JOURNAL ARTICLE
Sankar Maity, Somdev Pahari, Santanu Santra, Madhurima Jana
A series of atomistic molecular dynamics (MD) simulations were carried out with a hydrated 1,2-dimyristoyl- sn -glycero-3-phosphocholine (DMPC) bilayer with the variation of glucose concentrations from 0 to 30 wt % in the presence of 0.3 M NaCl. The study suggested that although the thickness of the lipid bilayer dropped significantly with the increase in glucose concentration, it expanded laterally at high glucose levels due to the intercalation of glucose between the headgroups of adjacent lipids. We adopted the surface assessment via the grid evaluation method to compute the deviation of the bilayer's key structural features for the different amounts of glucose present...
April 18, 2024: Journal of Chemical Information and Modeling
#7
JOURNAL ARTICLE
Sheng Shu, Yuko Tsutsui, Rajkanwar Nathawat, Wei Mi
Levels of lipopolysaccharide (LPS), an essential glycolipid on the surface of most gram-negative bacteria, are tightly controlled-making LPS synthesis a promising target for developing new antibiotics. Escherichia coli adaptor protein LapB (YciM) plays an important role in regulating LPS synthesis by promoting degradation of LpxC, a deacetylase that catalyzes the first committed step in LPS synthesis. Under conditions where LPS is abundant, LapB recruits LpxC to the AAA+ protease FtsH for degradation. LapB achieves this by simultaneously interacting with FtsH through its transmembrane helix and LpxC through its cytoplasmic domain...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#8
JOURNAL ARTICLE
Marina Hutchins, Tracy Douglas, Lea Pollack, Julia B Saltz
AbstractSocial behaviors can be influenced by the genotypes of interacting individuals through indirect genetic effects (IGEs) and can also display developmental plasticity. We investigated how developmental IGEs, which describe the effects of a prior social partner's genotype on later behavior, can influence aggression in male Drosophila melanogaster . We predicted that developmental IGEs cannot be estimated by simply extending the effects of contextual IGEs over time and instead have their own unique effects on behavior...
May 2024: American Naturalist
#9
JOURNAL ARTICLE
Mahdi Aarabi, Ankit Pandey, Bill Poirier
In this work, the <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>Crystal</mml:mi></mml:mrow> </mml:math> code, developed previously by the authors to find "holes" as well as legitimate transition states in existing potential energy surface (PES) functions [JPC Lett. 11, 6468 (2020)], is retooled to perform on-the-fly "direct dynamics"-type PES explorations, as well as automatic construction of new PES functions. In all of these contexts, the chief advantage of <mml:math xmlns:mml="https://www...
June 5, 2024: Journal of Computational Chemistry
#10
JOURNAL ARTICLE
Hongtao Yin, Lixiang Ma, Yanqing Zhou, Xiuying Tang, Runjun Li, Yingjun Zhou, Jiaxiu Shi, Jun Zhang
Effects of angiotensin receptor/neprilysin inhibitors (ARNI) on ventricular remodeling in patients with heart failure, especially heart failure with reduced ejection fraction (HFrEF), are better than those of angiotensin-converting enzyme inhibitors (ACEI). Acute myocardial infarction (AMI) complicated by mitral regurgitation exacerbates ventricular remodeling and increases the risk of heart failure. There is limited evidence on the effects of early administration of ARNI in patients with AMI complicated by mitral regurgitation...
April 18, 2024: Heart and Vessels
#11
REVIEW
Hadir Aljohani, Fares S Alrubaish, Waad M Alghamdi, Fawaz Al-Harbi
BACKGROUND: Linagliptin is an oral dipeptidyl peptidase DPP-4 inhibitor, which is indicated for the treatment of Type 2 diabetes mellitus (T2DM) as monotherapy or add-on to therapy with other hypoglycemic drugs. OBJECTIVES: We aimed to summarize the evidence from randomized controlled trials (RCTs) to assess the safety of linagliptin focusing on cardiovascular risks among subjects with type 2 diabetes mellitus. METHODS: We conducted a systematic search across the following databases: Medline, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials...
April 18, 2024: Therapeutic Innovation & Regulatory Science
#12
JOURNAL ARTICLE
I Vaněčková, J Zicha
A new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospitalization for heart failure...
April 18, 2024: Physiological Research
#13
JOURNAL ARTICLE
D Benak, F Kolar, M Hlavackova
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6-methyladenosine (m6A), N6,2'-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), pseudouridine (?), 5 methylcytidine (m5C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure...
April 18, 2024: Physiological Research
#14
JOURNAL ARTICLE
Juliana Meneghetti da Rosa, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Léia Sena, Renato Nisihara, Altair Rogerio Ambrosio, Iara J Messias-Reason
BACKGROUND: The process of tissue injury in coronary artery disease (CAD) has been associated with activation of the complement system, partly due to the action of mannose-binding lectin (MBL) and C3, which are expressed in atherosclerotic lesions. OBJECTIVE: The aim of this study was to evaluate the serum levels of MBL and C3 in patients with CAD and to compare them with healthy controls. Additionally, we aim to assess the correlation between MBL and C3 levels and cardiometabolic parameters...
April 18, 2024: Immunological Investigations
#15
JOURNAL ARTICLE
Lin Chen, Xuemei Tao, Minghui Zeng, Yuqin Li, Jiaxin Han, Yuekui Wang, Yonggang Liu, Ruifang Shi, Rui Su, Liang Xu, Yuqiang Mi
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a new nomenclature proposed in 2023. We aimed to compare the diagnostic efficacy of noninvasive tests (NITs) for advanced fibrosis under different nomenclatures in patients with chronic hepatitis B (CHB). A total of 844 patients diagnosed with CHB and concurrent steatotic liver disease (SLD) by liver biopsy were retrospectively enrolled and divided into four groups. The performances of fibrosis-4 (FIB-4), gamma-glutamyl transpeptidase to platelet ratio index (GPRI), aspartate aminotransferase to platelet ratio index (APRI), and liver stiffness measurement (LSM) were compared among the four groups...
April 2024: Journal of Medical Virology
#16
JOURNAL ARTICLE
Kang-Su Shin, Min-Seung Park, Mi Yeon Lee, Eun Hye Cho, Hee-Yeon Woo, Hyosoon Park, Min-Jung Kwon
Glycated albumin (GA) reflects glycemic status for the past three weeks. GA level demonstrates a strong correlation with HbA1c level and is used as an adjunctive biomarker for diagnosis and monitoring of type 2 diabetes mellitus (T2DM). In this study, we validated the predictive performance of baseline GA for development of T2DM in healthy individuals in Korea. From August 2013 to September 2014, the medical records of 3,771 healthy Koreans were retrospectively reviewed. Each participant was categorized into tertiles based on initial GA level...
April 18, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
#17
JOURNAL ARTICLE
Kylie Gorney
Recent years have seen a growing interest in the development of person-fit statistics for tests with polytomous items. Some of the most popular person-fit statistics for such tests belong to the class of standardized person-fit statistics, <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:mrow><mml:mi>T</mml:mi></mml:mrow> <mml:annotation>$$ T $$</mml:annotation></mml:semantics> </mml:math> , that is assumed to have a standard normal null distribution...
April 17, 2024: British Journal of Mathematical and Statistical Psychology
#18
JOURNAL ARTICLE
Chunlu Dong, Haidong Ma, Ningning Mi, Wenkang Fu, Jianfeng Yi, Long Gao, Haiping Wang, Yanxian Ren, Yanyan Lin, Fangfang Han, Zhou Chen, Wence Zhou
INTRODUCTION: Pancreatic cancer (PC) is a malignancy with poor prognosis. This investigation aimed to determine the relevant genes that affect the prognosis of PC and investigate their relationship with immune infiltration. METHODS: : First, we acquired PC single-cell chip data from the GEO database to scrutinize dissimilarities in immune cell infiltration and differential genes between cancerous and adjacent tissues. Subsequently, we combined clinical data from TCGA to identify genes relevant to PC prognosis...
2024: Frontiers in Oncology
#19
JOURNAL ARTICLE
Aaron A Gurayah, Ruben Blachman-Braun, Christopher J Machado, Matthew M Mason, Helen Y Hougen, Ali Mouzannar, Mark L Gonzalgo, Bruno Nahar, Sanoj Punnen, Dipen J Parekh, Chad R Ritch
OBJECTIVES: The objective of this study is to investigate the association between major adverse cardiac events (MACE) and clinical factors of patients undergoing radical cystectomy (RC) for bladder cancer. MATERIALS AND METHODS: A retrospective analysis using the 2015-2020 National Surgical Quality Improvement Program database was performed on patients who underwent RC for bladder cancer. MACE was defined as any report of cerebrovascular accident, myocardial infarction, or thromboembolic events (pulmonary embolism or deep vein thrombosis)...
April 2024: BJUI compass
#20
JOURNAL ARTICLE
Abdullah Baraean, Mahmoud Kassas, Md Shafiul Alam, Mohamed A Abido
This paper proposes an advanced control approach to controlling a DC-DC buck converter for a proton exchange membrane (PEM) electrolyzer within the framework of a direct current (DC) microgrid. The proposed adaptive backstepping terminal sliding mode control (ABTSMC) leverages a physics-informed neural network (PINN) to accurately estimate and compensate for system uncertainty. The composite controller achieves finite-time convergence of the tracking error by combining backstepping control and terminal sliding mode control (TSMC)...
April 15, 2024: Heliyon
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