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https://www.readbyqxmd.com/read/28230903/-evidence-based-medicine-in-eating-disorders-research-the-problem-of-confetti-p-values
#1
Helena Chmura Kraemer
Eating disorders hold a unique place among mental health disorders, in that salient symptoms can be objectively observed and measured rather than determined only from patient interviews or subjective evaluations. Because of this measurement advantage alone, evidence-based medicine would be expected there to make the most rapid strides. However, conclusions in Eating Disorders research, as in all medical research literature, often continue to be misleading or ambiguous. One major and long-known source of such problems is the misuse and misinterpretation of "statistical significance", with "p values" strewn throughout research papers like so much confetti, a problem that has become systemic, that is, enforced, rather than corrected, by the peer-review system...
February 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28229515/treatment-integrity-of-elaborated-semantic-feature-analysis-aphasia-therapy-delivered-in-individual-and-group-settings
#2
Vasiliki Kladouchou, Ilias Papathanasiou, Eva A Efstratiadou, Vasiliki Christaki, Katerina Hilari
BACKGROUND & AIMS: This study ran within the framework of the Thales Aphasia Project that investigated the efficacy of elaborated semantic feature analysis (ESFA). We evaluated the treatment integrity (TI) of ESFA, i.e., the degree to which therapists implemented treatment as intended by the treatment protocol, in two different formats: individual and group therapy. METHODS & PROCEDURES: Based on the ESFA manual, observation of therapy videos and TI literature, we developed two ESFA integrity checklists, for individual and group therapy, and used them to rate 15 videos of therapy sessions, delivered by three speech-language therapists (SLTs)...
February 23, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28222828/metabolic-consequences-of-obesity-and-insulin-resistance-in-polycystic-ovary-syndrome-diagnostic-and-methodological-challenges
#3
Yvonne M Jeanes, Sue Reeves
Women with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016...
February 22, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28218502/serous-tubal-intraepithelial-carcinomas-associated-with-high-grade-serous-ovarian-carcinomas-a-systematic-review
#4
REVIEW
F Chen, K Gaitskell, M J Garcia, A Albukhari, J Tsaltas, A A Ahmed
BACKGROUND: Serous tubal intraepithelial carcinomas (STICs) have been documented in high-grade serous ovarian carcinomas (HGSOCs). However, the rate of association between STICs and HGSOCs and, therefore, the fraction of HGSOCs that are likely to have originated from the fallopian tube (FT), has remained unclear. OBJECTIVE: To appraise the literature describing the association between STICs and established HGSOCs. SEARCH STRATEGY: Ovid MEDLINE and EMBASE were searched...
February 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28217021/central-pontine-myelinolysis-and-localized-fluorodeoxyglucose-uptake-seen-on-18-f-fdg-pet-ct
#5
Frederik Rønne, Peer Carsten Tfelt-Hansen, Lene Rørdam
Case report describing the finding of central pontine myelinolysis (CPM) using combined fluorine-18 ( (18)F)-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The patient was a known alcoholic who, during admission was under treatment for hyponatremia, showed a significant decline in both motor and cognitive function. Combined (18)F-FDG PET/CT showed localized FDG uptake in the pons, consistent with the finding of CPM observed on magnetic resonance imaging (MRI). CPM is a demyelinating lesion of the pons, resulting in several neurological symptoms...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28216838/color-matching-in-facial-prosthetics-a-systematic-review
#6
REVIEW
Rani Ranabhatt, Kamleshwar Singh, Ramashanker Siddharth, Shuchi Tripathi, Deeksha Arya
Color matching to the surrounding skin is extremely important in patients wearing maxillofacial prostheses. It is of utmost importance to know the different techniques of color matching and coloring in maxillofacial prostheses. The purpose of this study is to review the literature data with regard to color matching in maxillofacial prosthetics. An electronic search of peer review restricted to English language dental literature was conducted to identify the relevant scientific article on color matching and coloring in maxillofacial prostheses...
January 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28216013/methylmercury-exposure-and-cognitive-abilities-and-behavior-at-10years-of-age
#7
Klara Gustin, Fahmida Tofail, Fardina Mehrin, Michael Levi, Marie Vahter, Maria Kippler
BACKGROUND: Methylmercury (MeHg) is a known developmental neurotoxicant present in fish, yet the impact of childhood exposure is uncertain, especially in children with poor nutrition. OBJECTIVES: To evaluate associations of MeHg exposure with cognitive abilities and behavior in children from a poor rural area in Bangladesh. METHODS: The MeHg exposure was assessed in 1434 ten-year-old children by measuring mercury concentrations in hair (hair-Hg), using inductively coupled plasma mass spectrometry...
February 16, 2017: Environment International
https://www.readbyqxmd.com/read/28215137/the-australian-and-new-zealand-intensive-care-society-clinical-trials-group-point-prevalence-program-2009-2016
#8
Kelly Thompson, Naomi Hammond, Glenn Eastwood, Marino Festa, Parisa Glass, Dorrilyn Rajbhandari, Ian Seppelt, Colman Taylor, Nicola Watts, John Myburgh
BACKGROUND: Cross-sectional point prevalence studies collect observational data at a single time point and may be used to facilitate subsequent research hypotheses and discovery. METHODS: We report the process of implementation and substantive outputs of the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG) point prevalence program, conducted in participating intensive care units from 2009 to 2016. RESULTS: Seventy-seven of a maximum 197 adult ICUs across Australia and New Zealand participated in 9 specified study days over 18 days of data collection and collected data on 5043 participants, with an average of 44 ICUs per study day...
March 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28213797/long-term-outcomes-of-tot-and-tvt-procedures-for-the-treatment-of-female-stress-urinary-incontinence-a-systematic-review-and-meta-analysis
#9
REVIEW
Umberto Leone Roberti Maggiore, Enrico Finazzi Agrò, Marco Soligo, Vincenzo Li Marzi, Alex Digesu, Maurizio Serati
INTRODUCTION AND HYPOTHESES: One of the most relevant topics in the field of pelvic floor dysfunction treatment is the long-term efficacy of surgical procedures, in particular, the use of prosthesis. Hence, a systematic review and meta-analysis was conducted to evaluate the long-term effectiveness and safety of midurethral sling (MUS) procedures for stress urinary incontinence (SUI), as reported in randomised controlled trials (RCTs) and non-randomised studies. METHODS: This systematic review is based on material searched and obtained via PubMed/Medline, Scopus, and the Cochrane Library between January 2000 and October 2016...
February 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28213783/high-pten-gene-expression-is-a-negative-prognostic-marker-in-human-primary-breast-cancers-with-preserved-p53-function
#10
Synnøve Yndestad, Eilin Austreid, Stian Knappskog, Ranjan Chrisanthar, Peer Kåre Lilleng, Per Eystein Lønning, Hans Petter Eikesdal
PURPOSE: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer given neoadjuvant chemotherapy. METHODS: The association between pretreatment PTEN and PTENP1 gene expression, response to neoadjuvant chemotherapy, and recurrence-free and disease-specific survival was assessed in 364 patients with locally advanced breast cancer given doxorubicin, 5-fluorouracil/mitomycin, or epirubicin versus paclitaxel in three phase II prospective studies...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28213594/brighter-children-the-association-between-seasonality-of-birth-and-child-iq-in-a-population-based-birth-cohort
#11
Nina H Grootendorst-van Mil, Régine P M Steegers-Theunissen, Albert Hofman, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
OBJECTIVE: Season of birth has repeatedly been found to be a risk indicator for adverse neurodevelopmental outcomes. Several explanations for this finding have been put forward but no conclusion has been reached. In the current study, we explored the role of sociodemographic and biological factors in the association between season of birth and child IQ. DESIGN: In a prenatally recruited birth cohort (born in 2002-2006), we examined the association between season of birth and non-verbal IQ at age 6 years among 6034 children...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28213188/children-with-adhd-and-symptoms-of-oppositional-defiant-disorder-improved-in-behavior-when-treated-with-methylphenidate-and-adjuvant-risperidone-though-weight-gain-was-also-observed-results-from-a-randomized-double-blind-placebo-controlled-clinical-trial
#12
Leila Jahangard, Shahrokh Akbarian, Mohammad Haghighi, Mohammad Ahmadpanah, Amir Keshavarzi, Hafez Bajoghli, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
Children with ADHD often show symptoms of oppositional defiant disorders (ODD). We investigated the impact of adjuvant risperidone (RISP) to a standard treatment with methylphenidate (MPH) in children with ADHD and symptoms of ODD. Eighty-four children with ADHD and ODD (age: M=8.55; range: 7.28-9.95 years; 73.8% males) took part in a double-blind, randomized, placebo-controlled, clinical trial lasting eight weeks. Participants were randomly assigned either to the MPH+RISP (1mg/kg/d+0.5mg/d) or to the MPH+PLCO (1mg/kg/d+placebo) condition...
December 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28209517/inadvertent-hypothermia-and-mortality-in-critically-ill-adults-systematic-review-and-meta-analysis
#13
REVIEW
Panagiotis Kiekkas, Fotini Fligou, Michael Igoumenidis, Nikolaos Stefanopoulos, Evangelos Konstantinou, Vasilios Karamouzos, Diamanto Aretha
OBJECTIVE: Considering that inadvertent hypothermia (IH) is common in Intensive Care Unit (ICU) patients and can be followed by severe complications, this systematic review identified, appraised and synthesized the published literature about the association between IH and mortality in adults admitted to the ICU. DATA SOURCES: By using key terms, literature searches were conducted in Pubmed, CINAHL, Cochrane Library, Web of Science and EMBASE. REVIEW METHODS: According to PRISMA guidelines, articles published between 1980-2016 in English-language, peer-reviewed journals were considered...
February 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28207573/genome-wide-analysis-of-clopidogrel-active-metabolite-levels-identifies-novel-variants-that-influence-antiplatelet-response
#14
Joshua D Backman, Jeffrey R O'Connell, Keith Tanner, Cody J Peer, William D Figg, Shawn D Spencer, Braxton D Mitchell, Alan R Shuldiner, Laura M Yerges-Armstrong, Richard B Horenstein, Joshua P Lewis
Clopidogrel is one of the most commonly used therapeutics for the secondary prevention of cardiovascular events in patients with acute coronary syndromes. However, considerable interindividual variation in clopidogrel response has been documented, resulting in suboptimal therapy and an increased risk of recurrent events for some patients. In this investigation, we carried out the first genome-wide association study of circulating clopidogrel active metabolite levels in 513 healthy participants to directly measure clopidogrel pharmacokinetics...
February 15, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28207331/a-systematic-review-of-cardiovascular-disease-in-sexual-minorities
#15
Billy A Caceres, Abraham Brody, Rachel E Luscombe, Jillian E Primiano, Peter Marusca, Edward M Sitts, Deborah Chyun
BACKGROUND: Mental health and HIV disparities are well documented among sexual minorities, but there is a dearth of research on other chronic conditions. Cardiovascular disease remains the leading cause of death worldwide. Although sexual minorities have high rates of several modifiable risk factors for cardiovascular disease (including stress, tobacco use, and alcohol consumption), there is a paucity of research in this area. OBJECTIVES: In this systematic review, we synthesized and critiqued the existing evidence on cardiovascular disease among sexual minority adults...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28195028/academic-judgments-under-uncertainty-a-study-of-collective-anchoring-effects-in-swedish-research-council-panel-groups
#16
Lambros Roumbanis
This article focuses on anchoring effects in the process of peer reviewing research proposals. Anchoring effects are commonly seen as the result of flaws in human judgment, as cognitive biases that stem from specific heuristics that guide people when they involve their intuition in solving a problem. Here, the cognitive biases will be analyzed from a sociological point of view, as interactional and aggregated phenomena. The article is based on direct observations of ten panel groups evaluating research proposals in the natural and engineering sciences for the Swedish Research Council...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28194563/a-critical-evaluation-of-the-quality-of-published-13-c-nmr-data-in-natural-product-chemistry
#17
Wolfgang Robien
Nuclear Magnetic Resonance spectroscopy contributes very efficiently to the structure elucidation process in organic chemistry. Carbon-13 NMR spectroscopy allows direct insight into the skeleton of organic compounds and therefore plays a central role in the structural assignment of natural products. Despite this important contribution, there is no established and well-accepted workflow protocol utilized during the first steps of interpreting spectroscopic data and converting them into structural fragments and then combining them, by considering the given spectroscopic constraints, into a final proposal of structure...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28192226/use-of-preventive-medication-in-patients-with-limited-life-expectancy-a-systematic-review
#18
REVIEW
Arjun Poudel, Patsy Yates, Debra Rowett, Lisa M Nissen
CONTEXT: Optimal prescribing in patients with limited life expectancy remains unclear. OBJECTIVES: This study systematically reviews the published literature regarding the use of preventive medication in patients with reduced life expectancy. METHODS: A systematic literature search was conducted using three databases (MEDLINE, EMBASE and CINAHL). Articles published in English from January 1995 to December 2015 were retrieved for analysis to identify peer-reviewed, observational studies assessing use of preventive medications in patients with limited life expectancy...
February 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28190936/how-teacher-emotional-support-motivates-students-the-mediating-roles-of-perceived-peer-relatedness-autonomy-support-and-competence
#19
Erik A Ruzek, Christopher A Hafen, Joseph P Allen, Anne Gregory, Amori Yee Mikami, Robert C Pianta
Multilevel mediation analyses test whether students' mid-year reports of classroom experiences of autonomy, relatedness with peers, and competence mediate associations between early in the school year emotionally-supportive teacher-student interactions (independently observed) and student-reported academic year changes in mastery motivation and behavioral engagement. When teachers were observed to be more emotionally-supportive in the beginning of the school year, adolescents reported academic year increases in their behavioral engagement and mastery motivation...
April 2016: Learning and Instruction
https://www.readbyqxmd.com/read/28187164/biomechanics-of-fencing-sport-a-scoping-review
#20
Tony Lin-Wei Chen, Duo Wai-Chi Wong, Yan Wang, Sicong Ren, Fei Yan, Ming Zhang
OBJECTIVES: The aim of our scoping review was to identify and summarize current evidence on the biomechanics of fencing to inform athlete development and injury prevention. DESIGN: Scoping review. METHOD: Peer-reviewed research was identified from electronic databases using a structured keyword search. Details regarding experimental design, study group characteristics and measured outcomes were extracted from retrieved studies, summarized and information regrouped under themes for analysis...
2017: PloS One
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