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https://www.readbyqxmd.com/read/29470108/application-of-80-kvp-scan-and-raw-data-based-iterative-reconstruction-for-reduced-iodine-load-abdominal-pelvic-ct-in-patients-at-risk-of-contrast-induced-nephropathy-referred-for-oncological-assessment-effects-on-radiation-dose-image-quality-and-renal-function
#1
Yasunori Nagayama, Shota Tanoue, Akinori Tsuji, Joji Urata, Mitsuhiro Furusawa, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Eri Yoshida, Morikatsu Yoshida, Masafumi Kidoh, Machiko Tateishi, Yasuyuki Yamashita
OBJECTIVE: To evaluate the image quality, radiation dose, and renal safety of contrast medium (CM)-reduced abdominal-pelvic CT combining 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE) in patients with renal dysfunction for oncological assessment. METHODS: We included 45 patients with renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73m2) who underwent reduced-CM abdominal-pelvic CT (360 mgI/kg, 80-kVp, SAFIRE) for oncological assessment...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29469229/hypolipidemic-and-antioxidant-properties-of-oryzanol-concentrate-in-reducing-diabetic-nephropathy-via-srebp1-down-regulation-rather-than-beta-oxidation
#2
G Bhaskaragoud, V Geetha, T Sharanappa, A S Mohan Kumar, C Hema Kumar, G Suresh Kumar
SCOPE: Diabetic nephropathy (DN) is a micro-vascular complication of chronic diabetes. Sterol regulatory element binding protein1 (SREBP1) participation in the development of DN is reported. Oryzanol Concentrate (OC) at 0.1 and 0.3% was tested for its antioxidant and hypolipidemic effects. The aim of the work was to study the involvement of OC in the amelioration of DN in STZ induced diabetic animal model. METHODS AND RESULTS: Animals were grouped into Starch, High fat and OC treated control/diabetic groups (SFC/SFD, HFC/HFD, OFC/OFD)...
February 22, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29468160/adhesion-gpcrs-in-kidney-development-and-disease
#3
REVIEW
Salvador Cazorla-Vázquez, Felix B Engel
Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, kidney cancer represents 5% of all new diagnosed cancers. As currently no effective therapies exist to restore kidney function after CKD- as well as cancer-induced renal damage, it is important to elucidate new regulators of kidney development and disease as new therapeutic targets. G protein-coupled receptors (GPCRs) represent the most successful class of pharmaceutical targets...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29467950/genetic-polymorphisms-in-hla-dp-and-stat4-are-associated-with-iga-nephropathy-in-a-southwest-chinese-population
#4
Bin Yang, Junlong Zhang, Xinle Liu, Zhuochun Huang, Zhenzhen Su, Yun Liao, Lanlan Wang
IgA nephropathy (IgAN) is the most common chronic glomerular disease worldwide. Genetic factors are thought to be crucial in the pathogenesis of IgAN. However, few data are available on the relationship between human leucocyte antigen (HLA) and signal transducer and activator of transcription 4 (STAT4) polymorphisms and IgAN susceptibility in the Chinese population. Therefore, we examined HLA-DP/DQ and STAT4 polymorphisms (rs3077, rs9277535, rs7453920 and rs7574865) in a total of 630 subjects including 140 IgAN and 490 healthy controls in Chinese...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29466798/antithrombin-%C3%A2-is-a-novel-predictor-for-contrast-induced-nephropathy-after-coronary-angiography
#5
Rui Wu, Yiwei Kong, Jianyong Yin, Rulian Liang, Zeyuan Lu, Niansong Wang, Qing Zhao, Yang Zhou, Chungen Yan, Feng Wang, Mingyu Liang
BACKGROUND/AIMS: Antithrombin Ⅲ (AT Ⅲ) is an important endogenous anticoagulant and has strong anti-inflammatory properties. Low ATⅢ activity is considered to be a predictor of poor outcomes in several conditions, including acute kidney injury after cardiac surgery. However, the association between the ATⅢ level and the occurrence of contrast induced nephropathy (CIN) has not been elucidated. In this study, our aim was to identify the potential predictive value of ATⅢ for CIN...
February 16, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29465872/-acid-uric-key-player-in-a-recently-recognized-devastating-nephropathy-and-in-the-development-of-chronic-kidney-disease
#6
Antoine Humbert, Fabien Stucker
Uric acid has been known since long ago for its implication in gout and in certain kinds of nephrolithiasis. However, its role in models of acute and chronic nephropathies has been the focus of many new developments. The so called Mesoamerican nephropathy is a devastating disease that has caused more than 20'000 deaths in central America these last few years among sugarcane workers. Acid uric could play a key role in its physiopathology. Moreover, acid uric tends to be recognized as an independent factor of development and progression in chronic kidney disease, opening a way for new therapeutic targets...
February 21, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29465063/posterior-reversible-encephalopathy-syndrome-in-the-emergency-service
#7
M Yigit, E Yigit, K A Turkdogan
Posterior reversible encephalopathy syndrome (PRES) is an entity characterized by headache, altered mental status, seizures, visual disturbances, and focal neurological signs. The most common etiologies of PRES are hypertension and renal failure, and the most frequent pathophysiology is hyperperfusion. PRES is generally symmetrical, often in the occipital and parietal lobes, and is typically characterized by vasogenic edema in the subcortical white matter. This study involves a 38-year-old female patient who had hypertension, used immunosuppressive drugs and was also found to have nephropathy...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29464270/diabetes-modifies-the-role-of-prostanoids-and-potassium-channels-which-regulate-the-hypereactivity-of-the-rabbit-renal-artery-to-bnp
#8
José M Centeno, Luis Miranda-Gómez, Mikahela A López-Morales, Teresa Jover-Mengual, María C Burguete, Vannina G Marrachelli, María Castelló-Ruiz, Alicia Aliena-Valero, Enrique Alborch, Francisco J Miranda
Diabetic nephropathy is associated with increased risk of cardiovascular disease. B-type natriuretic peptide (BNP) plays an important role in cardiovascular pathophysiology and therapeutics. The aim of the present study was to investigate the influence of experimental diabetes on the mechanisms that regulate the relaxant response of the rabbit renal artery to BNP. Arterial relaxations to BNP were enhanced in diabetic rabbits. Indomethacin enhanced BNP-induced relaxation in control rabbits but showed no effect in diabetic rabbits...
February 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29464201/prediction-of-early-bk-virus-infection-in-kidney-transplant-recipients-by-the-number-of-cells-with-intranuclear-inclusion-bodies-decoy-cells
#9
Yoshiteru Yamada, Tomohiro Tsuchiya, Isao Inagaki, Mitsuru Seishima, Takashi Deguchi
Background: BK virus (BKV) is the cause of nephropathy. Because BKV nephropathy can progress to graft loss, early diagnosis of BKV infection is very important. In this study, we aimed to investigate the utility of quantifying cells with intranuclear inclusion bodies (decoy cells) in urinary sediment for the screening and monitoring of BKV infection in renal transplant recipients at our hospital. Methods: This was a retrospective single-center study. Urine sediment examination was performed at each outpatient visit, and the number of decoy cells was measured in the whole microscopic field...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464200/polyomavirus-bk-nephropathy-associated-transcriptomic-signatures-a-critical-reevaluation
#10
Ling Pan, Zili Lyu, Benjamin Adam, Gang Zeng, Zijie Wang, Yuchen Huang, Zahidur Abedin, Parmjeet Randhawa
Background: Recent work using DNA microarrays has suggested that genes related to DNA replication, RNA polymerase assembly, and pathogen recognition receptors can serve as surrogate tissue biomarkers for polyomavirus BK nephropathy (BKPyVN). Methods: We have examined this premise by looking for differential regulation of these genes using a different technology platform (RNA-seq) and an independent set 25 biopsies covering a wide spectrum of diagnoses. Results: RNA-seq could discriminate T cell-mediated rejection from other common lesions seen in formalin fixed biopsy material...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29463395/-cardiovascular-protection-of-diabetic-patient-with-chronic-renal-disease-and-particular-case-of-end-stage-renal-disease-in-elderly-patients
#11
P Zaoui, T Hannedouche, C Combe
Type 2 diabetes has an increasing prevalence. Life expectancy is dominated by cardiovascular risk, which is the leading cause of death in these patients. Up to one third of diabetic patients will develop diabetic nephropathy related to micro-angiopathy. Renal impairment further increases cardiovascular risk. Reducing cardiovascular morbidity and mortality is a major public health issue, as well as early preventing and managing chronic kidney disease (CKD). Good glycemic control prevents the micro-vascular complications of the disease (retinopathy, nephropathy, etc...
June 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29462869/modulation-of-vegf-a-alternative-splicing-as-a-novel-treatment-in-chronic-kidney-disease
#12
REVIEW
Megan Stevens, Sebastian Oltean
Vascular endothelial growth factor A (VEGF-A) is a prominent pro-angiogenic and pro-permeability factor in the kidney. Alternative splicing of the terminal exon of VEGF-A through the use of an alternative 3' splice site gives rise to a functionally different family of isoforms, termed VEGF-Axxx b, known to have anti-angiogenic and anti-permeability properties. Dysregulation of the VEGF-Axxx /VEGF-Axxx b isoform balance has recently been reported in several kidney pathologies, including diabetic nephropathy (DN) and Denys-Drash syndrome...
February 15, 2018: Genes
https://www.readbyqxmd.com/read/29462715/a-new-model-of-diabetic-nephropathy-in-c57bl-6-mice-challenged-with-advanced-oxidation-protein-products
#13
Xiaoyan Bai, Xiao Li, Jianwei Tian, Liting Xu, Jiao Wan, Youhua Liu
There remains a lack of robust mouse models with key features of advanced human diabetic nephropathy (DN). Few options of murine models of DN require mutations to be superimposed to obtain desired phenotypic characteristics. Most genetically modified mice are on the C57BL/6 background; however, they are notorious for resistance to develop DN. To overcome these conundrums, this study reports a novel DN model by challenging with advanced oxidation protein products (AOPPs) in streptozotocin-induced diabetic C57BL/6 mice...
February 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29462574/adiponectin-receptor-agonist-adiporon-decreased-ceramide-and-lipotoxicity-and-ameliorated-diabetic-nephropathy
#14
Sun Ryoung Choi, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Yaeni Kim, Beom Soon Choi, Yong-Soo Kim, Hye Won Kim, Kyung-Min Lim, Min Jeong Kim, Cheol Whee Park
BACKGROUND: Adiponectin is known to take part in the regulation of energy metabolism. AdipoRon, an orally-active synthetic adiponectin agonist, binds to both adiponectin receptors (AdipoR)1/R2 and ameliorates diabetic complications. Among the lipid metabolites, the ceramide subspecies of sphingolipids have been linked to features of lipotoxicity, including inflammation, cell death, and insulin resistance. We investigated the role of AdipoRon in the prevention and development of type 2 diabetic nephropathy...
February 17, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29461477/anti-renal-fibrotic-effect-of-exercise-training-in-hypertension
#15
Ching Huang, Yi-Yuan Lin, Ai-Lun Yang, Tang-Wei Kuo, Chia-Hua Kuo, Shin-Da Lee
The purpose of this study was to evaluate the effects of exercise training on renal fibrosis in hypertensive rats. Masson's trichrome staining and Western blotting were performed on the excised renal cortex from sixteen male spontaneously hypertensive rats (SHR), which were randomly divided into either a sedentary hypertensive group (SHR) or exercise hypertensive group (SHR-EX, running on an exercise treadmill for 60 min/day, 5 sessions/week, for 12 weeks), and from eight male Wistar-Kyoto rats which served as a sedentary normotensive group (WKY)...
February 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29461232/nephropathy-in-early-rheumatoid-arthritis-patients-does-a-significant-risk-exist
#16
D Rekalov, A Prytkova, R Kulynych, G Protsenko, V Protsenko
Objective of the study layed in assessment of the pathophysiological relation between cell-mediated immunity (tumor necrosis factor-alpha (TNF-α) inflammatory cytokine) activation and renal dysfunction in the patients with early rheumatoid arthritis. We analyzed the data from 35 early rheumatoid arthritis (RA) patients of average age of 50,71±2,25 years (ranged 18-76 years, 80% of women) with 9,21±0,43 months mean duration of the disease by the time of the study initiation. Urine and blood tests were performed to verify the main indicators of kidney function and inflammation cytokines significant interaction...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29460894/-the-clinical-and-morphological-characteristics-of-c1q-glomerulopathy
#17
V A Varshavsky, A N Grishina, N V Chebotareva, E I Gudkova
C1q glomerulopathy is a rare variety of chronic glomerulonephritis manifested as C1q deposition revealed by immunofluorescence microscopy. The pathogenesis and etiology of the disease have not been studied. The paper deals with the results of clinical, morphological, immunofluorescence, and electron microscopic examinations in 13 patients with C1q glomerulopathy. Light microscopy more commonly revealed membranous nephropathy, mesangioproliferative glomerulonephritis, and nephrosclerosis. Immunofluorescence microscopy detected a C1q fraction in association with other deposits, more frequently IgM and IgG ones...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29460412/the-relationship-between-hemoglobin-level-and-the-type-1-diabetic-nephropathy-in-anhui-han-s-patients
#18
Jun Jiang, Lan Lei, Xiaowan Zhou, Peng Li, Ren Wei
BACKGROUND: Recent studies have shown that low hemoglobin (Hb) level promote the progression of chronic kidney disease. This study assessed the relationship between Hb level and type 1 diabetic nephropathy (DN) in Anhui Han's patients. METHODS: There were a total of 236 patients diagnosed with type 1 diabetes mellitus and (T1DM) seen between January 2014 and December 2016 in our centre. Hemoglobin levels in patients with DN were compared with those without DN. The relationship between Hb level and the urinary albumin-creatinine ratio (ACR) was examined by Spearman's correlational analysis and multiple stepwise regression analysis...
February 20, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29459010/plasma-microrna-signature-of-patients-with-iga-nephropathy
#19
Jingjing Wu, Huo Zhang, Weiwei Wang, Mingxia Zhu, Lian-Wen Qi, Tongshan Wang, Wenfang Cheng, Jun Zhu, Xia Shan, Zebo Huang, Lan Zhang, Yan Chen, Bin Sun, Xiufen Zhao, Jun Qian, Wei Zhu, Xin Zhou, Changying Xing
We looked for differentially expressed MicroRNAs (miRNAs) in Immunoglobulin A nephropathy (IgAN). Forty-eight miRNAs were identified through the initial screening phase (2 IgAN pools vs. 1 normal control (NC) pool) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel (miRCURY-Ready-to-Use-PCR-Human-panel-I + II-V1 .M). By qRT-PCR, these miRNAs were further assessed in the training (32 IgAN VS. 31 NCs) and testing stages (51 IgAN VS. 51 NCs). The renal pathological lesions of patients with IgAN were evaluated according to Lee's grading system...
April 5, 2018: Gene
https://www.readbyqxmd.com/read/29458003/fgf-23-pth-and-vitamin-d-status-in-end-stage-renal-disease-patients-affected-by-vdr-foki-and-bsmi-variants
#20
Mouna Bouksila, Wajih Kaabachi, Mehdi Mrad, Wided Smaoui, Elhem Cheour El Kateb, Mohammed Karim Zouaghi, Kamel Hamzaoui, Afef Bahlous
OBJECTIVES: The aim of this study was to evaluate the association between two VDR SNPs FokI and BsmI and mineral status in ESRD patients. DESIGN AND METHODS: Our case-control study included 100 patients with chronic renal failure in ESRD and 149 healthy subjects. We measured the serum Vitamin D levels and the serum intact PTH level by Electrochemiluminescence Technology (cobas E411 analyzer). We evaluated the serum FGF23 levels by indirect ELISA method. The genotyping of two VDR gene variants FokI and BsmI was carried out by PCR-RFLP technique...
February 16, 2018: Clinical Biochemistry
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