Cleandra Gregório, Shefali Thakur, Raquel Camara Rivero, Simone Márcia Dos Santos Machado, Cyrille Cuenin, Christine Carreira, Valerie White, Ian A Cree, Katarina Vukojevic, Merica Glavina Durdov, Alessandro Bersch Osvaldt, Patricia Ashton-Prolla, Zdenko Herceg, Fazlur Rahman Talukdar
Genetic and epigenetic alterations of the telomere maintenance machinery like telomere length and telomerase reverse transcriptase (encoded by TERT gene) are reported in several human malignancies. However, there is limited knowledge on the status of the telomere machinery in periampullary carcinomas (PAC) which are rare and heterogeneous groups of cancers arising from different anatomic sites around the ampulla of Vater. In the current study, we investigated the relative telomere length (RTL) and the most frequent genetic and epigenetic alterations in the TERT promoter in PAC and compared it with tumor-adjacent nonpathological duodenum (NDu)...
May 5, 2023: Gene