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Periampullary carcinoma

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https://www.readbyqxmd.com/read/28353594/does-the-pancreatic-volume-reduction-rate-using-serial-computed-tomographic-volumetry-predict-new-onset-diabetes-after-pancreaticoduodenectomy
#1
Sung Pil Yun, Hyung-Il Seo, Suk Kim, Dong Uk Kim, Dong Hoon Baek
Volume reduction of the pancreatic tissues following a pancreatectomy can lead to the deterioration of glucose homeostasis. This is defined as pancreatogenic diabetes mellitus (DM). The objective of this study was to investigate the occurrence of new-onset DM (NODM) and evaluate the risk factors, including the pancreas volume reduction rate in patients undergoing pancreaticoduodenectomy (PD).Sixty-six patients without preoperative DM underwent PD for periampullary tumors between August 2007 and December 2012 and were included in this analysis...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28351309/plasma-microrna192-in-combination-with-serum-ca19-9-as-non-invasive-prognostic-biomarker-in-periampullary-carcinoma
#2
K Murali Manohar, Mitnala Sasikala, Yesaswini Kvsrr, V Sunil, Rupjyoti Talukdar, Hvv Murthy, C Ramji, G V Rao, R Pradeep, D Nageshwar Reddy
In this study, circulating microRNAs (miRNAs) are being investigated as non-invasive biomarkers for early diagnosis and prognosis of human cancers. Since the prognosis for pancreatobiliary subtype of periampullary carcinoma is poor, we assessed the prognostic relevance of miRNAs in combination with CA19-9 as noninvasive biomarker in periampullary carcinoma. Circulating miRNAs in plasma and serum CA19-9 were evaluated in periampullary carcinoma patients (n = 109) undergoing Whipple's pancreaticoduodenectomy and in healthy volunteers (n = 92)...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28260769/morbidity-and-mortality-after-pancreatoduodenectomy-a-five-year-experience-in-bangabandhu-sheikh-mujib-medical-university
#3
B C Das, A S Khan, N E Elahi, M S Uddin, B C Debnath, Z R Khan
Mortality and morbidity was assessed after adoption of a systematic care for patient with pancreatoduodenectomy starting from patient selection and preparation, operative technique, and postoperative care. In this prospective study seventy patients who underwent pancreatoduodenectomy for periampullary carcinoma with curative intent between January 2010 and December 2014 were carefully analyzed prospectively. Patients were selected those who had ampullary carcinoma, lower bile duct carcinoma and small size carcinoma head of pancreas without local invasion and distant metastasis, and the patient who did not have any major disabling comorbid diseases...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28151854/endoscopic-radiofrequency-ablation-combined-with-fully-covered-self-expandable-metal-stent-for-inoperable-periampullary-carcinoma-in-a-liver-transplant-patient-a-case-report
#4
Qing Tian, Guijie Wang, Yamin Zhang, Yan Jin, Zilin Cui, Xiaoye Sun, Zhongyang Shen
RATIONALE: Postliver transplant periampullary carcinoma is an extremely uncommon disease. PATIENT CONCERNS: Cutaneous jaundice in a patient who had received a liver transplant 4 years earlier. DIAGNOSIS: Periampullary carcinoma. INTERVENTIONS: Radiofrequency ablation plus fully covered self-expanding metal stents (FCSEMS). OUTCOMES: The treatment of malignant neoplasm of the ampulla of Vater is the patient by radiofrequency ablation plus FCSEMS placement was successful...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28087967/periampullary-carcinoma-with-penile-metastasis
#5
W C Pui, N A Nik Azim
Periampullary carcinoma metastases are usually located at regional nodes, adjacent organs, liver or lung. On the other hand, metastatic penile cancer is uncommon. Penile metastasis usually originates from pelvic region with prostate and bladder being the most frequent primary location. We present a very rare case of periampullary carcinoma with penile metastasis in a 49-year-old man. He initially presented with early ampullary type periampullary carcinoma and had pyloric preserving pancreatoduodenectomy and adjuvant chemotherapy...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28029673/histopathologic-analysis-of-pancreaticoduodenectomy-specimen
#6
R Dhakhwa, N Kafle
INTRODUCTION: Whipple's Pancreaticoduodenectomy has increasingly been used as an appropriate resectional procedure for tumors of the periampullary region which are pancreatic, periampullary, ampullary and biliary tumors. Our aim was to study the distribution and histopathologic features of these tumors and to examine local trends of periampullary neoplasms resected with a PD. METHODS: A descriptive study was conducted in the department of Pathology, Kathmandu Medical College Teaching Hospital from July 2013 to June 2016...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27994339/carcinoma-of-the-ampulla-of-vater-associated-with-annular-pancreas
#7
Mallika Tewari, Ashish Verma, H S Shukla
Carcinoma of the ampulla of Vater associated with annular pancreas is a rare entity. Only seven cases have been reported so far in the English literature. We herein report one such case in a 42-year-lady who presented with progressively increasing jaundice and pain in the upper abdomen for past 2 months. A magnetic resonance cholangiopancreaticography (MRCP) and MRI revealed an annular pancreas with an ampullary mass and a dilated CBD. An upper gastrointestinal endoscopic biopsy from the ampullary mass revealed a moderately differentiated adenocarcinoma...
October 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27859270/impact-of-pancreatectomy-on-long-term-patient-reported-symptoms-and-quality-of-life-in-recurrence-free-survivors-of-pancreatic-and-periampullary-neoplasms
#8
Jordan M Cloyd, Hop S Tran Cao, Maria Q B Petzel, Jason W Denbo, Nathan H Parker, Graciela M Nogueras-González, Joseph S Liles, Michael P Kim, Jeffrey E Lee, Jean-Nicolas Vauthey, Thomas A Aloia, Jason B Fleming, Matthew H G Katz
BACKGROUND: Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy. METHODS: We conducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal adenocarcinoma, periampullary carcinomas, and pancreatic neuroendocrine tumors who had undergone prior pancreatectomy. QOL and symptom burden were measured using the Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire, and psychosocial distress was measured using the Hospital Anxiety and Depression Scale...
February 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27776651/double-contrast-enhanced-ultrasonography-in-the-detection-of-periampullary-cancer-comparison-with-b-mode-ultrasonography-and-mr-imaging
#9
COMPARATIVE STUDY
Ting Zhang, Zhong-Zhen Su, Ping Wang, Tao Wu, Wen Tang, Er-Jiao Xu, Jin-Xiu Ju, Xian-Yue Quan, Rong-Qin Zheng
PURPOSE: To investigate the value of double contrast-enhanced ultrasonography (DCEUS) in the detection of periampullary cancer. MATERIALS AND METHODS: Ninety-nine patients with surgery or biopsy-proven periampullary cancer who underwent both DCEUS and magnetic resonance imaging (MRI) examinations before operation were enrolled in our study. DCEUS in which intravenous microbubbles were used in combination with oral contrast agent and MRI were performed preoperatively to make a detection diagnosis of periampullary cancer...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27721277/does-hepatocyte-paraffin-1-expression-stand-a-role-in-determining-the-site-origin-of-an-adenocarcinoma-from-unknown-gastrointestinal-primary
#10
Rajni Yadav, Saurav Chopra, Aayushi Garg, Brijnandan Gupta, Prateek Kinra, Siddhartha Datta Gupta, Prasenjit Das
BACKGROUND: Hepatocyte Paraffin 1 (Hep Par 1) was being extensively used to recognize the hepatocellular carcinomas, until recognition of its expression in tumors without hepatocellular differentiation. AIMS AND OBJECTIVES: The aim of this study was to analyze if Hep Par 1 stain can serve as a specific marker of the small intestinal (SI) adenocarcinomas, versus other gastrointestinal tract (GIT) primary tumors. MATERIALS AND METHODS: In this retrospective cross-sectional study, normal GIT mucosa (n - 60), corresponding adenocarcinomas (n - 60) and nodal metastatic foci (n - 60) from the same patients, including 10 cases each from the esophagus, stomach, SI periampullary region, colon, rectum, and gall bladder were included...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27602165/apc-promoter-is-frequently-methylated-in-pancreatic-juice-of-patients-with-pancreatic-carcinomas-or-periampullary-tumors
#11
Mireia M Ginesta, Zamira Vanessa Diaz-Riascos, Juli Busquets, Núria Pelaez, Teresa Serrano, Miquel Àngel Peinado, Rosa Jorba, Francisco Javier García-Borobia, Gabriel Capella, Joan Fabregat
Early detection of pancreatic and periampullary neoplasms is critical to improve their clinical outcome. The present authors previously demonstrated that DNA hypermethylation of adenomatous polyposis coli (APC), histamine receptor H2 (HRH2), cadherin 13 (CDH13), secreted protein acidic and cysteine rich (SPARC) and engrailed-1 (EN-1) promoters is frequently detected in pancreatic tumor cells. The aim of the present study was to assess their prevalence in pancreatic juice of carcinomas of the pancreas and periampullary area...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27570419/management-of-gastric-and-duodenal-neuroendocrine-tumors
#12
REVIEW
Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27561734/isolating-tape-method-is-useful-for-an-early-judgment-of-curability-during-pancreaticoduodenectomy-for-pancreatic-cancer
#13
Shuichi Fujioka, Takeyuki Misawa, Katsuhiko Yanaga
Positive surgical margin of extrapancreatic nerve plexus (ENP) is a major cause of non-curative resection during pancreaticoduodenectomy (PD) for periampullary carcinoma (PC), which is difficult to detect at the early stage of PD. We describe a novel surgical technique using an isolating tape (iTape)-oriented ENP-first dissection (IOEFD) during PD. The iTape is firstly passed through the retroperitoneal space between ENP and inferior vena cava. Then, the iTape is further extracted from major vessels such as the common hepatic and superior mesenteric artery...
October 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27517148/kras-mutation-as-a-prognostic-factor-in-ampullary-adenocarcinoma-a-meta-analysis-and-review
#14
Bum Jun Kim, Hyun Joo Jang, Jung Han Kim, Hyeong Su Kim, Jin Lee
Ampullary adenocarcinoma (A-AC) is a rare malignancy arising from the ampulla of Vater. KRAS mutation is detected in 30-40% of patients with A-AC, but its clinical implication and prognostic value are not well described. We conducted this meta-analysis to investigate the association between KRAS mutation and prognosis in patients with A-AC. We searched Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases for articles including following terms in their titles, abstracts, or keywords: 'ampullary or periampullary or ampulla of vater', 'cancer or carcinoma', and 'KRAS'...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27484980/long-term-outcomes-and-prognostic-factors-in-periampullary-carcinoma
#15
Bhanu Jayanand Sunil, Ramakrishnan A Seshadri, S Gouthaman, Rama Ranganathan
PURPOSE: The aim of the study was to analyze the long-term survival and the various prognostic factors that influence overall survival in patients undergoing pancreaticoduodenectomy (PD) with non-pancreatic periampullary carcinomas. METHODS: A retrospective analysis of consecutive patients diagnosed with non-pancreatic periampullary carcinomas who underwent PD at a tertiary cancer center was performed. Univariate analysis of various prognostic factors influencing the disease-free survival (DFS) was performed using log-rank test...
August 3, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27456015/microrna-expression-in-a-readily-accessible-common-hepatic-artery-lymph-node-predicts-time-to-pancreatic-cancer-recurrence-postresection
#16
Hai V Nguyen, Jesse Gore, Xin Zhong, Sudha S Savant, Samantha Deitz-McElyea, C Max Schmidt, Michael G House, Murray Korc
Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27376210/resection-reconstruction-of-aberrant-right-hepatic-artery-during-whipple-procedure-pancreaticoduodenectomy
#17
Raza Sayyed, Iffat Rehman, Imran Khalid Niazi, Muhammed Aasim Yusuf, Aamir Ali Syed, Faisal V
Aberrant hepatic arterial anatomy poses a challenge for the surgeon during Whipple procedure. Intraoperative injury to the aberrant vasculature results in hemorrhagic or ischemic complications involving the liver and biliary tree. We report a case of replaced right hepatic artery arising from the superior mesenteric artery in a patient with periampullary carcinoma of the pancreas, undergoing pancreaticoduodenectomy. The aberrant artery was found to be coursing through the pancreatic parenchyma. This is a rare vascular anomaly...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27190786/contrast-enhanced-computed-tomographic-study-on-the-prevalence-of-duodenal-diverticulum-in-indian-population
#18
B Minu Rekha, Anuradha Chandramohan, B Sudhakar Chandran, Visalakshi Jayaseelan, J Suganthy
INTRODUCTION: Duodenal diverticulum (DD) is the second most common diverticulum, yet its incidence varies widely from 1-22% based on the mode of investigation. Computed Tomography (CT) of abdomen is the preferred modality to diagnose acute abdomen including those of complications of DD. Moreover, the prevalence of DD in Indian population is not yet been studied using CT. AIM: The current study aim to look for the prevalence of DD in Indian population using Contrast Enhanced Computed Tomography (CECT) abdomen...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27124014/successful-experience-of-laparoscopic-pancreaticoduodenectomy-and-digestive-tract-reconstruction-with-minimized-complications-rate-by-14-case-reports
#19
Yong Fan, Yanhui Zhao, Lan Pang, Yingxing Kang, Boxiong Kang, Yongyong Liu, Jie Fu, Bowei Xia, Chen Wang, Youcheng Zhang
Laparoscopic pancreatic surgery is one of the most sophisticated and advanced applications of laparoscopy in the current surgical practice. The adoption of laparoscopic pancreaticoduodenectomy (LPD) has been relatively slow due to the technical challenges. The aim of this study is to review and characterize our successful LPD experiences in patients with distal bile duct carcinoma, periampullary adenocarcinoma, pancreas head cancer, and duodenal cancer and evaluate the clinical outcomes of LPD for its potential in oncologic surgery applications...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27072272/heterogeneous-expression-of-cholecystokinin-and-gastrin-receptor-in-stomach-and-pancreatic-cancer-an-immunohistochemical-study
#20
Rajani Rai, Jong Joo Kim, Mallika Tewari, Hari Shankar Shukla
AIM: Cholecystokinin (CCK) and gastrin (Gs) are a well known trophic factor for the gastrointestinal tract and their trophic effects are shown mainly toward pancreas and stomach, respectively. Though, the exact characterization of CCK and Gs receptors subtype (cholecystokinin type A receptor [CCKAR] and cholecystokinin type B receptor/gastrin receptor [CCKBR/GR]) in stomach cancer (SC) and pancreatic cancer (PC) is still controversial and necessities further validation. SUBJECTS AND METHODS: CCKAR and CCKBR/GR expression was analyzed by immunohistochemistry in 55 SC, 25 benign gastric diseases (BGDs), 38 PC (including periampullary carcinoma), and 10 normal pancreatic tissue...
January 2016: Journal of Cancer Research and Therapeutics
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