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Periampullary carcinoma

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https://www.readbyqxmd.com/read/27859270/impact-of-pancreatectomy-on-long-term-patient-reported-symptoms-and-quality-of-life-in-recurrence-free-survivors-of-pancreatic-and-periampullary-neoplasms
#1
Jordan M Cloyd, Hop S Tran Cao, Maria Q B Petzel, Jason W Denbo, Nathan H Parker, Graciela M Nogueras-González, Joseph S Liles, Michael P Kim, Jeffrey E Lee, Jean-Nicolas Vauthey, Thomas A Aloia, Jason B Fleming, Matthew H G Katz
BACKGROUND: Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy. METHODS: We conducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal adenocarcinoma, periampullary carcinomas, and pancreatic neuroendocrine tumors who had undergone prior pancreatectomy. QOL and symptom burden were measured using the Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire, and psychosocial distress was measured using the Hospital Anxiety and Depression Scale...
November 11, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27776651/double-contrast-enhanced-ultrasonography-in-the-detection-of-periampullary-cancer-comparison-with-b-mode-ultrasonography-and-mr-imaging
#2
Ting Zhang, Zhong-Zhen Su, Ping Wang, Tao Wu, Wen Tang, Er-Jiao Xu, Jin-Xiu Ju, Xian-Yue Quan, Rong-Qin Zheng
PURPOSE: To investigate the value of double contrast-enhanced ultrasonography (DCEUS) in the detection of periampullary cancer. MATERIALS AND METHODS: Ninety-nine patients with surgery or biopsy-proven periampullary cancer who underwent both DCEUS and magnetic resonance imaging (MRI) examinations before operation were enrolled in our study. DCEUS in which intravenous microbubbles were used in combination with oral contrast agent and MRI were performed preoperatively to make a detection diagnosis of periampullary cancer...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27721277/does-hepatocyte-paraffin-1-expression-stand-a-role-in-determining-the-site-origin-of-an-adenocarcinoma-from-unknown-gastrointestinal-primary
#3
Rajni Yadav, Saurav Chopra, Aayushi Garg, Brijnandan Gupta, Prateek Kinra, Siddhartha Datta Gupta, Prasenjit Das
BACKGROUND: Hepatocyte Paraffin 1 (Hep Par 1) was being extensively used to recognize the hepatocellular carcinomas, until recognition of its expression in tumors without hepatocellular differentiation. AIMS AND OBJECTIVES: The aim of this study was to analyze if Hep Par 1 stain can serve as a specific marker of the small intestinal (SI) adenocarcinomas, versus other gastrointestinal tract (GIT) primary tumors. MATERIALS AND METHODS: In this retrospective cross-sectional study, normal GIT mucosa (n - 60), corresponding adenocarcinomas (n - 60) and nodal metastatic foci (n - 60) from the same patients, including 10 cases each from the esophagus, stomach, SI periampullary region, colon, rectum, and gall bladder were included...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27602165/apc-promoter-is-frequently-methylated-in-pancreatic-juice-of-patients-with-pancreatic-carcinomas-or-periampullary-tumors
#4
Mireia M Ginesta, Zamira Vanessa Diaz-Riascos, Juli Busquets, Núria Pelaez, Teresa Serrano, Miquel Àngel Peinado, Rosa Jorba, Francisco Javier García-Borobia, Gabriel Capella, Joan Fabregat
Early detection of pancreatic and periampullary neoplasms is critical to improve their clinical outcome. The present authors previously demonstrated that DNA hypermethylation of adenomatous polyposis coli (APC), histamine receptor H2 (HRH2), cadherin 13 (CDH13), secreted protein acidic and cysteine rich (SPARC) and engrailed-1 (EN-1) promoters is frequently detected in pancreatic tumor cells. The aim of the present study was to assess their prevalence in pancreatic juice of carcinomas of the pancreas and periampullary area...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27570419/management-of-gastric-and-duodenal-neuroendocrine-tumors
#5
REVIEW
Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27561734/isolating-tape-method-is-useful-for-an-early-judgment-of-curability-during-pancreaticoduodenectomy-for-pancreatic-cancer
#6
Shuichi Fujioka, Takeyuki Misawa, Katsuhiko Yanaga
Positive surgical margin of extrapancreatic nerve plexus (ENP) is a major cause of non-curative resection during pancreaticoduodenectomy (PD) for periampullary carcinoma (PC), which is difficult to detect at the early stage of PD. We describe a novel surgical technique using an isolating tape (iTape)-oriented ENP-first dissection (IOEFD) during PD. The iTape is firstly passed through the retroperitoneal space between ENP and inferior vena cava. Then, the iTape is further extracted from major vessels such as the common hepatic and superior mesenteric artery...
October 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27517148/kras-mutation-as-a-prognostic-factor-in-ampullary-adenocarcinoma-a-meta-analysis-and-review
#7
Bum Jun Kim, Hyun Joo Jang, Jung Han Kim, Hyeong Su Kim, Jin Lee
Ampullary adenocarcinoma (A-AC) is a rare malignancy arising from the ampulla of Vater. KRAS mutation is detected in 30-40% of patients with A-AC, but its clinical implication and prognostic value are not well described. We conducted this meta-analysis to investigate the association between KRAS mutation and prognosis in patients with A-AC. We searched Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases for articles including following terms in their titles, abstracts, or keywords: 'ampullary or periampullary or ampulla of vater', 'cancer or carcinoma', and 'KRAS'...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27484980/long-term-outcomes-and-prognostic-factors-in-periampullary-carcinoma
#8
Bhanu Jayanand Sunil, Ramakrishnan A Seshadri, S Gouthaman, Rama Ranganathan
PURPOSE: The aim of the study was to analyze the long-term survival and the various prognostic factors that influence overall survival in patients undergoing pancreaticoduodenectomy (PD) with non-pancreatic periampullary carcinomas. METHODS: A retrospective analysis of consecutive patients diagnosed with non-pancreatic periampullary carcinomas who underwent PD at a tertiary cancer center was performed. Univariate analysis of various prognostic factors influencing the disease-free survival (DFS) was performed using log-rank test...
August 3, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27456015/microrna-expression-in-a-readily-accessible-common-hepatic-artery-lymph-node-predicts-time-to-pancreatic-cancer-recurrence-postresection
#9
Hai V Nguyen, Jesse Gore, Xin Zhong, Sudha S Savant, Samantha Deitz-McElyea, C Max Schmidt, Michael G House, Murray Korc
Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27376210/resection-reconstruction-of-aberrant-right-hepatic-artery-during-whipple-procedure-pancreaticoduodenectomy
#10
Raza Sayyed, Iffat Rehman, Imran Khalid Niazi, Muhammed Aasim Yusuf, Aamir Ali Syed, Faisal V
Aberrant hepatic arterial anatomy poses a challenge for the surgeon during Whipple procedure. Intraoperative injury to the aberrant vasculature results in hemorrhagic or ischemic complications involving the liver and biliary tree. We report a case of replaced right hepatic artery arising from the superior mesenteric artery in a patient with periampullary carcinoma of the pancreas, undergoing pancreaticoduodenectomy. The aberrant artery was found to be coursing through the pancreatic parenchyma. This is a rare vascular anomaly...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27190786/contrast-enhanced-computed-tomographic-study-on-the-prevalence-of-duodenal-diverticulum-in-indian-population
#11
B Minu Rekha, Anuradha Chandramohan, B Sudhakar Chandran, Visalakshi Jayaseelan, J Suganthy
INTRODUCTION: Duodenal diverticulum (DD) is the second most common diverticulum, yet its incidence varies widely from 1-22% based on the mode of investigation. Computed Tomography (CT) of abdomen is the preferred modality to diagnose acute abdomen including those of complications of DD. Moreover, the prevalence of DD in Indian population is not yet been studied using CT. AIM: The current study aim to look for the prevalence of DD in Indian population using Contrast Enhanced Computed Tomography (CECT) abdomen...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27124014/successful-experience-of-laparoscopic-pancreaticoduodenectomy-and-digestive-tract-reconstruction-with-minimized-complications-rate-by-14-case-reports
#12
Yong Fan, Yanhui Zhao, Lan Pang, Yingxing Kang, Boxiong Kang, Yongyong Liu, Jie Fu, Bowei Xia, Chen Wang, Youcheng Zhang
Laparoscopic pancreatic surgery is one of the most sophisticated and advanced applications of laparoscopy in the current surgical practice. The adoption of laparoscopic pancreaticoduodenectomy (LPD) has been relatively slow due to the technical challenges. The aim of this study is to review and characterize our successful LPD experiences in patients with distal bile duct carcinoma, periampullary adenocarcinoma, pancreas head cancer, and duodenal cancer and evaluate the clinical outcomes of LPD for its potential in oncologic surgery applications...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27072272/heterogeneous-expression-of-cholecystokinin-and-gastrin-receptor-in-stomach-and-pancreatic-cancer-an-immunohistochemical-study
#13
Rajani Rai, Jong Joo Kim, Mallika Tewari, Hari Shankar Shukla
AIM: Cholecystokinin (CCK) and gastrin (Gs) are a well known trophic factor for the gastrointestinal tract and their trophic effects are shown mainly toward pancreas and stomach, respectively. Though, the exact characterization of CCK and Gs receptors subtype (cholecystokinin type A receptor [CCKAR] and cholecystokinin type B receptor/gastrin receptor [CCKBR/GR]) in stomach cancer (SC) and pancreatic cancer (PC) is still controversial and necessities further validation. SUBJECTS AND METHODS: CCKAR and CCKBR/GR expression was analyzed by immunohistochemistry in 55 SC, 25 benign gastric diseases (BGDs), 38 PC (including periampullary carcinoma), and 10 normal pancreatic tissue...
January 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27059701/synchronous-malignancies-of-the-gall-bladder-and-common-bile-duct-a-case-report
#14
Srinivas Kodaganur, Ishwar R Hosamani
BACKGROUND: Synchronous malignancies of the gall bladder and common bile duct are a rare entity. Much of our knowledge on this topic comes from Japanese literature. Most of the synchronous carcinomas described in Japanese literature are associated with the presence of an anomalous pancreatic-bile duct junction (APBDJ). CASE PRESENTATION: We report a case of synchronous malignancy of the extrahepatic biliary tree involving the fundus of the gall bladder and the intrapancreatic portion of the common bile duct (CBD)...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27048910/groove-pancreatitis-vs-pancreatic-adenocarcinoma-a-review-of-8-cases
#15
Francisco Sánchez-Bueno, Gloria Torres Salmerón, Jesús de la Peña Moral, Eduardo Ortiz Ruiz, Matilde Fuster Quiñonero, Wilfredo Víctor Gutiérrez Zárate, María Antonia Claver Valderas, Pascual Parrilla Paricio
INTRODUCTION: Groove pancreatitis (PS) is an uncommon clinical situation and radiologically it can mimic carcinoma of the periampullary area. The aim of this paper is to study a series of 8 patients who underwent surgery with preoperative diagnosis of pancreatic head mass and subsequent pathological diagnosis of PS. METHODS: In our series, 6 were men and 2 women, with an average age of 51,9 years. Before surgery, all patients had epigastric abdominal pain requiring analgesia at high doses...
June 2016: Cirugía Española
https://www.readbyqxmd.com/read/27037200/volume-outcome-relationships-in-pancreatoduodenectomy-for-cancer
#16
Lydia G M van der Geest, L Bengt van Rijssen, I Quintus Molenaar, Ignace H de Hingh, Bas Groot Koerkamp, Olivier R C Busch, Valery E P P Lemmens, Marc G H Besselink
BACKGROUND: Volume-outcome relationships in pancreatic surgery are well established, but an optimal volume remains to be determined. Studies analyzing outcomes in volume categories exceeding 20 procedures annually are lacking. STUDY DESIGN: A consecutive 3420 patients underwent PD for primary pancreatic or periampullary carcinoma (2005-2013) and were registered in the Netherlands Cancer Registry. Relationships between hospital volume (< 5, 5-19, 20-39 and ≥ 40 PDs/year) and mortality and survival were explored...
April 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27014423/endoscopic-retrograde-cholangiopancreatography-in-periampullary-diverticulum-the-challenge-of-cannulation
#17
REVIEW
Ahmed Youssef Altonbary, Monir Hussein Bahgat
Periampullary diverticulum (PAD) is duodenal outpunching defined as herniation of the mucosa or submucosa that occurs via a defect in the muscle layer within an area of 2 to 3 cm around the papilla. Although PAD is usually asymptomatic and discovered incidentally during endoscopic retrograde cholangiopancreatography (ERCP), it is associated with different pathological conditions such as common bile duct obstruction, pancreatitis, perforation, bleeding, and rarely carcinoma. ERCP has a low rate of success in patients with PAD, suggesting that this condition may complicate the technical application of the ERCP procedure...
March 25, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26977032/partial-resection-of-the-pancreatic-head-and-duodenum-for-management-of-carcinoma-of-the-ampulla-of-vater-a-case-report
#18
Xiao-Fang Liu, Kun Tang, Fu-Bo Sun, Lu-Lu Sui, Gang Xu
A 57-year-old woman presented with spontaneous pain in the upper right quadrant of the abdominal region of one year's duration. Contrast-enhanced computed tomography (CT), magnetic resonance imaging, and magnetic resonance cholangiopancreaticography revealed the presence of a tumour in the periampullary region, gallstones, cholecystitis, and biliary obstruction, as well as atrophy of the pancreas and dense adhesions involving the pancreas, portal vein, and superior mesenteric vein. Duodenoscopy revealed a papillary neoplasm, measuring 2...
March 2016: Anticancer Research
https://www.readbyqxmd.com/read/26960437/-endoscopic-therapy-for-gastroduodenal-neuroendocrine-neoplasms
#19
S Maasberg, C Jürgensen, F Scheerer, R Pschowski, S Felder, N Begum, B Wiedenmann, A Pascher, U-F Pape
Neuroendocrine neoplasms (NEN) represent a group of potentially malignant tumors, which can be located in every section of the gastrointestinal tract, the pancreas and the bronchopulmonary system. Gastroduodenal NENs have a relatively good prognosis in comparison to other subentities, e.g. pancreatic or ileojejunal NENs. In the stomach there are four different types of NENs, while in the duodenum there are five types and all vary in the malignant potential and the therapeutic approach. Due to the simple access endoscopic methods not only have diagnostic but also important therapeutic relevance in this subgroup...
April 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/26943678/primary-squamous-cell-carcinoma-of-the-ampulla-of-vater-a-case-report
#20
B Balci, B Calik, T Karadeniz, H Sahin, L Ugurlu, C Aydin
BACKGROUND: Primary squamous cell carcinoma of the ampulla of Vater is a very rare type of tumor, and the prognosis is not well known mainly due to a limited number of cases reported. Here, we aimed to report a case with primary squamous cell carcinoma of the ampulla of Vater. CASE PRESENTATION: A 54-year-old woman presented with weight loss, jaundice, and pain in the epigastric and right upper quadrant of the abdomen. With extensive radiological imaging, the patient was diagnosed with periampullary tumor and Whipple's procedure was performed...
December 2016: Surgical Case Reports
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