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https://www.readbyqxmd.com/read/29223137/sysmex-uf-1000i-flow-cytometer-to-screen-urinary-tract-infections-the-uriscam-multicentre-study
#1
O Herráez, M A Asencio, R Carranza, M M Jarabo, M Huertas, O Redondo, A Arias, S Jiménez-Álvarez, S Solís, P Zamarrón, M S Illescas, M A Galán
The new Sysmex UF-1000i analyzer - which incorporates bacteria morphology distinction - allows to automatically screen samples to be cultured at microbiology laboratories. We have evaluated the feasibility and accuracy of Sysmex UF-1000i to screen urine tract infections (UTIs). A total amount of 2,468 urine samples from six Spanish hospitals were analysed. Demographic and clinical data such as age, gender, source and sample type, preserving conditions, cytometer parameters (bacteria, leucocytes, and bacteria morphology) as well as urine culture results (gold standard) were recorded...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29223133/how-stress-contributes-to-autoimmunity-lessons-from-sj%C3%A3-gren-s-syndrome-ss
#2
REVIEW
Fotini N Skopouli, Stergios Katsiougiannis
A large body of clinical evidence on the association between stressful life events and autoimmune diseases suggests that stress may play an important role in the pathogenesis of these disorders. In this article, we discuss the effects of stress, not on the immune system but on specific cell populations against which the autoimmune reactivity is directed. Using Sjögren's syndrome as a model autoimmune disease, we review the role of stress in the initiation and perpetuation of autoimmune reactivity. We present data that reveal the effects of stress on salivary gland epithelial cells, suggesting that stress can become immunogenic through its various effects on salivary gland epithelium...
December 9, 2017: FEBS Letters
https://www.readbyqxmd.com/read/29222963/preoperative-biliary-drainage-adversely-affects-surgical-outcomes-in-periampullary-cancer-a-retrospective-and-propensity-score-matched-analysis
#3
Hongeun Lee, Youngmin Han, Jae Ri Kim, Wooil Kwon, Sun-Whe Kim, Jin-Young Jang
BACKGROUND/PURPOSE: The use of PBD for managing patients with periampullary cancer awaiting surgery remains controversial. The impact of PBD status and type on surgical outcomes has not been established, leading to a lack of consensus. We aimed to evaluate the impact of preoperative biliary drainage (PBD) on short-term surgical outcomes in curatively resected periampullary cancer. METHODS: We retrospectively reviewed data from patients undergoing curative periampullary cancer resection...
December 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29222954/evaluation-of-motion-artifact-metrics-for-coronary-ct-angiography
#4
Hongfeng Ma, Eric Gros, Aniko Szabo, Scott G Baginski, Zachary R Laste, Naveen M Kulkarni, Darin Okerlund, Taly G Schmidt
PURPOSE: This study quantified the performance of coronary artery motion artifact metrics relative to human observer ratings. Motion artifact metrics have been used as part of motion correction and best-phase selection algorithms for Coronary Computed Tomography Angiography (CCTA). However, the lack of ground truth makes it difficult to validate how well the metrics quantify the level of motion artifact. This study investigated five motion artifact metrics, including two novel metrics, using a dynamic phantom, clinical CCTA images, and an observer study that provided ground truth motion artifact scores from a series of pairwise comparisons...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29222950/tolerance-design-of-patient-specific-range-qa-using-the-dmaic-framework-in-proton-therapy
#5
Jeong-Eun Rah, Dongho Shin, Ryan P Manger, Tae Hyun Kim, Do Hoon Oh, Dae Yong Kim, Gwe-Ya Kim
PURPOSE: To implement the DMAIC (Define-Measure-Analyze-Improve-Control) can be used for customizing the patient-specific QA by designing site-specific range tolerances. METHODS: The DMAIC framework (process flow diagram, cause and effect, Pareto chart, control chart, and capability analysis) were utilized to determine the steps that need focus for improving the patient-specific QA. The patient-specific range QA plans were selected according to 7 treatment site groups, a total of 1437 cases...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29222949/a-switch-from-gaba-inhibition-to-excitation-of-vasopressin-neurons-exacerbates-the-development-angiotensin-ii-dependent-hypertension
#6
Aaron K Korpal, Su Young Han, Daryl O Schwenke, Colin H Brown
Hypothalamic magnocellular neurons secrete vasopressin into the systemic circulation to maintain blood pressure by increasing renal water reabsorption and by vasoconstriction. When blood pressure rises, baroreflex activation normally inhibits vasopressin neurons via activation of GABAergic inputs. However, plasma vasopressin levels are paradoxically elevated in several models of hypertension and in some patients with essential hypertension, despite increased blood pressure. We have previously shown that vasopressin neuron activity is increased early in the development of moderate angiotensin II-dependent hypertension via blunted baroreflex inhibition of vasopressin neurons...
December 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29222948/force-coordination-strategies-in-on-water-single-sculling-are-asymmetries-related-to-better-rowing-performance
#7
John Warmenhoven, Richard Smith, Conny Draper, Andrew Harrison, Norma Bargary, Stephen Cobley
Asymmetries of the rowing stroke cycle have been assessed with reference to kinematics and foot-force measures in laboratory testing environments. It remains unclear how asymmetries in propulsive kinetic measures are related to on-water rowing performance. A new approach for the evaluation of both global and local asymmetries across the entire movement was used to assess the continuous role of asymmetries and whether these change according to level of competitive representation. Twenty seven highly skilled female rowers (national and international competition level), rowing at 32 strokes per minute in a single scull boat were evaluated...
December 9, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29222929/hiv-deceased-donor-referrals-a-national-survey-of-organ-procurement-organizations
#8
Ayla Cash, Xun Luo, Eric K H Chow, Mary Grace Bowring, Ashton A Shaffer, Brianna Doby, Corey E Wickliffe, Charles Alexander, Deborah McRann, Aaron A R Tobian, Dorry L Segev, Christine M Durand
BACKGROUND: HIV-infected (HIV+) donor organs can be transplanted into HIV+ recipients under the HIV Organ Policy Equity (HOPE) Act. Quantifying HIV+ donor referrals received by Organ Procurement Organizations (OPOs) is critical for HOPE Act implementation. METHODS: We surveyed the 58 US OPOs regarding HIV+ referral records and newly discovered HIV+ donors. Using data from OPOs that provided exact records and CDC HIV prevalence data, we projected a national estimate of HIV+ referrals...
December 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29222922/survival-of-children-after-liver-transplantation-for-hepatocellular-carcinoma
#9
Ulrich Baumann, René Adam, Christophe Duvoux, Rafael Mikolajczyk, Vincent Karam, Lorenzo D'Antiga, Christophe Chardot, Ahmet Coker, Michele Colledan, Bo-Goran Erizon, Pål Dag Line, Nedim Hadzic, Helena Isoniemi, Jürgen L Klempnauer, Raymond Reding, Patrick J McKiernan, Valérie McLin, Andreas Paul, Mauro Salizzoni, Emanuel San Bento Furtado, Stefan Schneeberger, André Karch
Hepatocellular carcinoma (HCC) in childhood differs from adult HCC as it is often associated with inherited liver disease. It is, however, unclear whether liver transplantation (LT) for HCC in childhood with or without associated inherited disease has a comparable outcome to adult HCC. Based on data from the European Liver Transplant Registry (ELTR) we aimed to investigate if there are differences in patient and graft survival after LT for HCC between children and adults and between patients with underlying inherited versus non inherited liver disease respectively...
December 9, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29222916/transplanting-hcv-positive-livers-into-hcv-negative-patients-with-preemptive-antiviral-treatment-a-modeling-study
#10
Jagpreet Chhatwal, Sumeyye Samur, Emily D Bethea, Turgay Ayer, Fasiha Kanwal, Chin Hur, Mark S Roberts, Norah Terrault, Raymond T Chung
Under current guidelines hepatitis C virus (HCV)-positive livers are not transplanted into HCV-negative recipients because of adverse post-transplant outcomes associated with allograft HCV infection. However, HCV can now be cured post liver transplant (LT) using direct-acting antivirals (DAAs) with >90% success; therefore, HCV-negative patients on the liver transplant (LT) waiting list may benefit from accepting HCV-positive organs with preemptive treatment. Our objective was to evaluate if and in which HCV-negative patients the potential benefit of accepting an HCV-positive (i...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29222911/current-and-future-therapeutic-regimens-for-non-alcoholic-fatty-liver-disease-nafld-and-non-alcoholic-steatohepatitis-nash
#11
REVIEW
Zobair M Younossi, Rohit Loomba, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Naga P Chalasani, Quentin M Anstee, Kris V Kowdley, Jacob George, Zachary D Goodman, Keith Lindor
NASH/NAFLD is rapidly becoming one of top causes of cirrhosis, hepatocellular carcinoma and indication for liver transplantation. Except for life style modification through diet and exercise, there are currently no other approved treatments for NASH/NAFLD. Although weight loss can be effective, it is hard to achieve and sustain. In contrast, bariatric surgery can improve metabolic conditions associated with NAFLD and has been shown to improve liver histology. In order to have approved regimens for treatment of NASH/NAFLD, a number of issues that must be addressed...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29222910/associations-between-maoa-uvntr-genotype-maltreatment-maoa-methylation-and-alcohol-consumption-in-young-adult-males
#12
Megha Bendre, Erika Comasco, Dave Checknita, Jari Tiihonen, Sheilagh Hodgins, Kent W Nilsson
BACKGROUND: Epigenetic mechanisms are candidate moderators of the effect of maltreatment on brain and behavior. Interactions between maltreatment and the Monoamine Oxidase A upstream variable number tandem repeat genotype (MAOA-uVNTR) are associated with alcohol-related problems. However, presently it is not known whether DNA methylation moderates this association. The study focused on fifty-three young adult males and aimed to determine: whether MAOA methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment; and whether alcohol consumption moderated the association of MAOA methylation with the interaction of MAOA-uVNTR and maltreatment...
December 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29222899/prevalence-and-determinants-of-iron-deficiency-anemia-among-non-pregnant-women-of-reproductive-age-in-pakistan
#13
Muhammad Atif Habib, Camille Raynes-Greenow, Sajid Bashir Soofi, Noshad Ali, Sidrah Nausheen, Imran Ahmed, Zulfiqar Ahmed Bhutta, Kirsten I Black
BACKGROUND AND OBJECTIVES: Iron deficiency Anemia (IDA) in women of reproductive age is a recognized public health concern that impairs health and well-being in women and is associated with adverse reproductive outcomes. In Pakistan there is a dearth of up-to-date information on the prevalence and predictors of IDA. This study sought to investigate IDA in Pakistani women. METHODS AND STUDY DESIGN: Secondary analysis was performed using the National Nutrition Survey in Pakistan 2011- 2012...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222869/new-generation-cardioverter-defibrillator-lead-with-a-floating-atrial-sensing-dipole-long-term-performance
#14
Erdal Safak, Giuseppe D Ancona, Hilmi Kaplan, Evren Caglayan, Stephan Kische, Alper Öner, Hüseyin Ince, Jasmin Ortak
OBJECTIVES: Study aim is to present the long-term performance of a new generation implantable cardioverter defibrillator (ICD) electrode with floating atrial dipole (Linox S DX, Biotronik). BACKGROUND: The single ICD electrode with a floating dipole in the atrial chamber was introduced about 15 years ago to overcome risk of inappropriate shock. METHODS: After implant, internal ECG data were prospectively collected via tele-monitoring (Home Monitoring, Biotronik)...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222861/zero-fluoroscopy-permanent-pacemaker-implantation-using-ensite-navx-system-clinical-viability-or-fanciful-technique
#15
Ping Guo, Jie Qiu, Yan Wang, Guangzhi Chen, Riccardo Proietti, Al-Selmi Fadhle, Chunxia Zhao, Dao Wen Wang
BACKGROUND: Fluoroscopy is the imaging modality routinely used for cardiac device implantation and electrophysiological procedures. Due to the rising concern regarding the harmful effects of radiation exposure to both the patients and operation staffs, novel 3D mapping systems have been developed and implemented in electrophysiological procedure for the navigation of catheters inside the heart chambers. Their applicability in cardiac device implantation has been rarely reported. Our aim is to evaluate the feasibility and safety of permanent pacemaker implantation without fluoroscopy...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222840/detection-of-neuropathic-pain-in-end-stage-cancer-patients-diagnostic-accuracy-of-two-questionnaires
#16
Eleftheria Tzamakou, Anastasios Petrou, Louiza Tefa, Vassiliki Siafaka, Eleni Laou, Petros Tzimas, Georgios Pentheroudakis, Georgios Papadopoulos
INTRODUCTION: Neuropathic pain in a frequent consequence of cancer pain. Quite often, in the end stage, it is difficult to discern its presence and delineate its characters in the context of cancer painful complications. The aim of this study was to compare the diagnostic accuracy of the translated to native language DN4 and PainDETECT questionnaires, for the diagnosis of peripheral neuropathic pain in oncology patients. METHODS: End stage cancer patients that presented to the Outpatient Pain Clinic were prospectively followed...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222836/biochemical-and-structural-insights-into-a-thermostable-cellobiohydrolase-from-myceliophthora-thermophila
#17
Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β-1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase MtCel7A, which is composed by a GH7-catalytic domain (CD), a linker and a CBM1-type carbohydrate binding module...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222823/dominant-role-of-microglial-and-macrophage-innate-immune-responses-in-human-ischemic-infarcts
#18
Tobias Zrzavy, Joana Machado-Santos, Sheren Christine, Christoph Baumgartner, Howard L Weiner, Oleg Butovsky, Hans Lassmann
Inflammatory mechanisms, involving granulocytes, T-cells, B-cells, macrophages and activated microglia, have been suggested to play a pathogenic role in experimental models of stroke and may be targets for therapeutic intervention. However, knowledge on the inflammatory response in human stroke lesions is limited. Here, we performed a quantitative study on the inflammatory reaction in human ischemic infarct lesions. We found increased numbers of T-lymphocytes, mainly CD8+ cells, but not of B-lymphocytes. Their number was very low in comparison to that seen in inflammatory diseases of the central nervous system and they did not show signs of activation...
December 8, 2017: Brain Pathology
https://www.readbyqxmd.com/read/29222813/reln-signaling-modulates-glioblastoma-growth-and-substrate-dependent-migration
#19
Markus Schulze, Christ Violonchi, Stefan Swoboda, Tobias Welz, Eugen Kerkhoff, Sabine Hoja, Susanne Brüggemann, Johann Simbürger, Jörg Reinders, Markus J Riemenschneider
Glioblastoma (GBM) represents the most common and most malignant type of primary brain tumor and significantly contributes to cancer morbidity and mortality. Invasion into the healthy brain parenchyma is a major feature of glioblastoma aggressiveness. Reelin (RELN) is a large secreted extracellular matrix glycoprotein that regulates neuronal migration and positioning in the developing brain and sustains functionality in the adult brain. We here show that both RELN and its main downstream effector DAB1 are silenced in glioblastoma as compared to non-neoplastic tissue and mRNA expression is inversely correlated with malignancy grade...
December 8, 2017: Brain Pathology
https://www.readbyqxmd.com/read/29222678/dose-responses-for-mortality-from-cerebrovascular-and-heart-diseases-in-atomic-bomb-survivors-1950-2003
#20
Helmut Schöllnberger, Markus Eidemüller, Harry M Cullings, Cristoforo Simonetto, Frauke Neff, Jan Christian Kaiser
The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose-response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well...
December 8, 2017: Radiation and Environmental Biophysics
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