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https://www.readbyqxmd.com/read/28350969/mechanisms-of-spontaneous-pacing-sa-nodal-cells-neonatal-cardiomyocytes-and-human-stem-cell-derived-cardiomyocytes
#1
Martin Morad, Xiaohua Zhang
The sino-atrial node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current I<sub><i>f</i></sub>, encoded by Hyperpolarization-activated cyclic nucleotide-gated (HCN) genes, contributes significantly to pacing, which in tandem with inward current generated by efflux of Ca<sup>2+</sup> via the Na<sup>+</sup>-Ca<sup>2+</sup> exchanger (NCX), resulting from the released Ca<sup>2+</sup>, mediates the diastolic depolarization...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350851/alcohol-related-changes-in-the-intestinal-microbiome-influence-neutrophil-infiltration-inflammation-and-steatosis-in-early-alcoholic-hepatitis-in-mice
#2
Patrick P Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V Ward, Gyongyi Szabo
BACKGROUND: Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function and is essential in the development of alcoholic liver disease. Here, we investigate changes in enteric microbiome composition in a model of early alcoholic steatohepatitis and dissect the pathogenic role of intestinal microbes in alcohol-induced liver pathology. MATERIALS AND METHODS: Wild type mice received a 10-day diet that was either 5% alcohol-containing or an isocaloric control diet plus a single binge...
2017: PloS One
https://www.readbyqxmd.com/read/28350807/external-validation-and-comparison-of-two-variants-of-the-elixhauser-comorbidity-measures-for-all-cause-mortality
#3
Yannick Fortin, James A G Crispo, Deborah Cohen, Douglas S McNair, Donald R Mattison, Daniel Krewski
Assessing prevalent comorbidities is a common approach in health research for identifying clinical differences between individuals. The objective of this study was to validate and compare the predictive performance of two variants of the Elixhauser comorbidity measures (ECM) for inhospital mortality at index and at 1-year in the Cerner Health Facts® (HF) U.S. DATABASE: We estimated the prevalence of select comorbidities for individuals 18 to 89 years of age who received care at Cerner contributing health facilities between 2002 and 2011 using the AHRQ (version 3...
2017: PloS One
https://www.readbyqxmd.com/read/28350719/previous-emergency-medical-services-use-by-victims-of-child-homicide
#4
Rohit P Shenoi, Anriada Nassif, Elizabeth A Camp, Faria A Pereira
INTRODUCTION: The medical diagnoses and frequency of emergency department visits made by children who are later given a diagnosis of maltreatment do not differ much from those of nonabused children. However, the type of medical complaints and frequency of emergency medical services (EMS) use by child homicide victims before their death are not known. We compared EMS use between child homicide victims and children who died from natural causes before their death. METHODS: This was a retrospective case-control study of children 0 to 5 years old who died in Houston, Texas, from 2005 to 2010...
March 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28346789/resolving-ultrafast-photoinduced-deactivations-in-water-solvated-pyrimidine-nucleosides
#5
Ana J Pepino, Javier Segarra-Martí, Artur Nenov, Roberto Improta, Marco Garavelli
For the first time, ultrafast deactivations of photo-excited water-solvated pyrimidine nucleosides are mapped employing hybrid QM(CASPT2)/MM(AMBER) optimizations that account for explicit solvation, sugar effects and dynamically correlated potential energy surfaces. Low energy S1/S0 ring-puckering and ring-opening conical intersections (CIs) are suggested to drive the ballistic coherent sub-ps (<200fs) decays observed in each pyrimidine, the energetics controlling this processes correlating with the lifetimes observed...
March 27, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28346766/maternal-thyroid-parameters-in-pregnant-women-with-different-ethnic-backgrounds-do-ethnicity-specific-reference-ranges-improve-the-diagnosis-of-subclinical-hypothyroidism
#6
Flora Veltri, Julie Belhomme, Pierre Kleynen, Lidia Grabczan, Serge Rozenberg, Thierry Pepersack, Kris Poppe
OBJECTIVE: Guidelines on the management of thyroid dysfunction during pregnancy have recently been updated and, for the diagnosis of subclinical hypothyroidism (SCH), a TSH upper reference limit (cutoff) of 4.0 mIU/L has been proposed when no institutional values are available. It is also suggested that serum TSH and thyroid autoimmunity (TAI) may be different according to the ethnic background of the women. We therefore determined the prevalence of TAI and SCH in pregnant women with different ethnic backgrounds and, to define SCH, we used different first trimester TSH upper reference cutoffs (institutional, ethnicity-specific, 2...
March 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28346734/when-meta-analysis-fails-a-case-about-stomata
#7
Christian Körner
In a recent paper, Yan et al. (2017) offered a statistical re-assessment of the response of stomata density in leaves to environmental conditions using published data sets, including (pre-)historical time series, environmental gradients and manipulative experiments. The authors arrive at a few trends and they conclude that the issue is complicated, responses vary and there is a need for better research. This meta-analysis, like many previous ones, suffered from insufficient or missing data stratification and employing inappropriate assumptions...
March 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28346728/nubpl-a-novel-metastasis-related-gene-promotes-colorectal-carcinoma-cell-motility-by-inducing-emt
#8
Yuhui Wang, Nan Wu, Donglin Sun, Haiming Sun, Dandan Tong, Duo Liu, Bo Pang, Su Li, Jia Wei, Jialin Dai, Yang Liu, Jing Bai, Jingshu Geng, Songbin Fu, Yan Jin
NUBPL is an assembly factor for human mitochondrial complex I, which is the biggest member of mitochondrial respiratory chain. However, the relationship between NUBPL and carcinoma progression remains unknown. In this study, NUBPL was characterized for its role in colorectal cancer (CRC) and the underlying molecular mechanisms. Data (n=197) from Oncomine database revealed that mRNA levels of NUBPL were remarkably overexpressed in CRC tissues compared with normal tissues. In addition, immunohistochemical analysis of 75 pairs of CRC and nontumorous tissues demonstrated that expression level of NUBPL was significantly higher in CRC tissues, and its expression level was positively associated with lymph node metastasis (P=0...
March 27, 2017: Cancer Science
https://www.readbyqxmd.com/read/28346696/do-people-trust-dentists-development-of-the-dentist-trust-scale
#9
Jason M Armfield, Manon Ketting, Sergio Chrisopoulos, Sarah R Baker
BACKGROUND: This study aimed to adapt a measure of trust in physicians generally to trust in dentists and to assess the reliability and validity of the measure. METHODS: Questionnaire data were collected from a simple random sample of 596 Australian adults. The 11-item General Trust in Physicians Scale (Hall et al., 2002) was modified to apply to dentists. RESULTS: The Dentist Trust Scale (DTS) had good internal consistency (Cronbach's alpha = 0...
March 27, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28346694/-holy-anorexia-relevant-or-relic-religiosity-and-anorexia-nervosa-among-finnish-women
#10
Pyry Sipilä, Gulnara Harrasova, Linda Mustelin, Richard J Rose, Jaakko Kaprio, Anna Keski-Rahkonen
Since medieval times, an association between religiosity and anorexia nervosa has been suggested, but few systematic studies exist. This study examines in a nationwide setting whether personal or family religiosity is associated with lifetime anorexia nervosa among women in adolescence and early adulthood. Women (N = 2,825) from the 1975 to 1979 birth cohorts of Finnish twins were screened for lifetime DSM-5 anorexia nervosa (N = 92). Parental religiosity was assessed by self-report when the women were aged 16 years...
March 27, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28346681/obstructive-sleep-apnea-and-postoperative-complications-among-patients-undergoing-gynecologic-oncology-surgery
#11
Olumuyiwa A Bamgbade, Rong R Khaw, Raisah S Sawati, Cathrine M Holland
OBJECTIVE: To investigate the prevalence of obstructive sleep apnea (OSA), physiological or risk factors associated with OSA, and OSA-associated postoperative complications among patients undergoing gynecologic oncology surgery. METHODS: A prospective observational study was done of gynecologic oncology patients undergoing abdominal surgery at a center in the UK between August 2009 and January 2013. All patients underwent perioperative sleep oximetry for the diagnosis of OSA...
March 27, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28346670/neospora-caninum-in-beef-herds-in-new-south-wales-australia-2-analysis-of-risk-factors
#12
B J Moloney, C Heuer, P D Kirkland
OBJECTIVE: To determine the influence of farm-level and animal-level factors on the seroprevalence of antibodies to Neospora caninum and associations between seropositivity and reproductive outcomes. METHODS: A questionnaire for a cross-sectional survey was posted to the 63 properties with a herd size ≥50 beef breeding cows that had participated in a previous seroprevalence study. Correspondence analysis, which does not appear to have been used previously in any Australian studies of livestock diseases, was used in conjunction with logistic regression to analyse the data...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28346354/anti-inflammatory-properties-of-irisin-mediator-of-physical-activity-are-connected-with-tlr4-myd88-signaling-pathway-activation
#13
Agnieszka Irena Mazur-Bialy, Ewa Pocheć, Marcin Zarawski
Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of adipose tissue and it has potentially protective properties in the development of obesity-related states, such as insulin resistance, arteriosclerosis, and type 2 diabetes. Despite numerous studies conducted on this factor, still little is known about its impact on the functioning of immunocompetent cells, but its potential anti-inflammatory properties were previously suggested. In the current study we investigated the role of irisin (0-100 nM) in the downstream pathway activation of Toll-like receptor 4 (TLR4) in RAW 264...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28346289/%C3%AE-blocker-use-and-reduced-disease-progression-in-patients-with-thick-melanoma-8-years-of-follow-up
#14
Vincenzo De Giorgi, Marta Grazzini, Silvia Benemei, Niccolò Marchionni, Pierangelo Geppetti, Sara Gandini
Previous observational studies have reported the protective effect of β-blockers on the progression of different types of cancers. In 2011, we published a prospective study, including patients with histologically confirmed malignant melanoma in stage II-IIIA. In total, 25% of them reported previous use of β-blockers that were administered at any time for any other diseases. After a median follow-up of 2.5 years, 34% of the patients in the untreated group showed disease progression. In contrast, only 3% of the patients in the treated group showed progression...
March 24, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28346255/splash-safety-during-dermatologic-procedures-among-us-dermatology-residents
#15
Dorota Z Korta, Lance W Chapman, Patrick K Lee, Kenneth G Linden
BACKGROUND: Dermatologists are at potential risk of acquiring infections from contamination of the mucous membranes by blood and body fluids. However, there are little data on splash safety during procedural dermatology. OBJECTIVE: To determine dermatology resident perceptions about splash risk during dermatologic procedures and to quantify the rate of protective equipment use. METHODS: An anonymous on-line survey was sent to 108 United States ACGME-approved dermatology residency programs assessing frequency of facial protection during dermatologic procedures, personal history of splash injury, and, if applicable, reasons for not always wearing facial protection...
March 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28346027/biologically-based-mechanistic-models-of-radiation-related-carcinogenesis-applied-to-epidemiological-data
#16
W Rühm, M Eidemüller, J C Kaiser
PURPOSE: Biologically-based mechanistic models that are used in combining current understanding of human carcinogenesis with epidemiological studies were reviewed. Assessment was made of how well they fit the data, whether they account for non-linear radiobiological low-dose effects, and whether they suggest any implications for the dose response at low doses and dose rates. However, the present paper does not make an attempt to provide a complete review of the existing literature on biologically-based models and their application to epidemiological data...
March 27, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#17
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345785/nanog-overexpression-and-its-correlation-with-stem-cell-and-differentiation-markers-in-meningiomas-of-different-who-grades
#18
Diana Freitag, Aaron Lawson McLean, Michèle Simon, Arend Koch, Susanne Grube, Jan Walter, Rolf Kalff, Christian Ewald
NANOG, as a key regulator of pluripotency and acting synergistically with other factors, has been described as a crucial transcription factor in various types of cancer. In meningiomas the expression of this marker has not yet been described. With our study, we aimed to identify and localize Nanog and other possible markers of pluripotency, stem cell properties and differentiation in meningioma tissue, to elucidate a possible effect on tumorigenesis. The gene expression levels of NANOG (NANOG1 and NANOGP8), SOX2, OCT4, KLF4, ABCG2, CMYC, MSI1, CD44, NOTCH1, NES, SALL4B, TP53 and EPAS1 were quantitatively examined using RT-qPCR in 33 surgical specimens of low- (WHO grade I) as well as in atypical and anaplastic (WHO grade II/III) meningiomas with dural tissue as reference...
March 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28345783/natural-tolerance-development-in-cow-s-milk-allergic-children-ige-and-igg4-epitope-binding
#19
Jean Christoph Caubet, Jing Lin, Birgit Ahrens, Gustavo Gimenez, Luda Bardina, Bodo Niggemann, Hugh A Sampson, Kirsten Beyer
BACKGROUND: Although most of cow's milk (CM) allergic children will outgrow their allergy, the pathomechanism of the natural development of tolerance remains poorly understood. It has been suggested that the balance between milk specific IgE and IgG4 plays a major role. OBJECTIVE: We aimed to investigate differences in IgE and IgG4 antibody binding to cow's milk (CM) epitopes between patients with persistent CM allergy (CMA) and those that naturally became tolerant...
March 27, 2017: Allergy
https://www.readbyqxmd.com/read/28345766/%C3%AE-linolenic-acid-and-exercise-training-independently-and-additively-decreases-blood-pressure-and-prevents-diastolic-dysfunction-in-obese-zucker-rats
#20
Pierre-Andre Barbeau, Tanya M Holloway, Jamie Whitfield, Brittany Baechler, Joe Quadrilatero, Luc J C van Loon, Adrian Chabowski, Graham P Holloway
While α-linolenic acid (ALA) and endurance exercise training independently attenuate hyperlipidemia-related cardiovascular derangements, there is a paucity of information pertaining to their mechanisms-of-action and efficacy when combined as a preventative therapeutic approach. Therefore, we used obese Zucker rats to investigate the independent and combined effects of these interventions on cardiovascular disease. Specifically, animals were randomly assigned to one of the following: control diet-sedentary (C-Sed), ALA supplemented-sedentary (ALA-Sed), control diet-exercise trained (C-Ex), or ALA supplemented-exercise trained (ALA-Ex)...
March 27, 2017: Journal of Physiology
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