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https://www.readbyqxmd.com/read/29155102/targeting-of-rac1-prevents-bronchoconstriction-and-airway-hyperresponsiveness
#1
Gwennan André-Grégoire, Florian Dilasser, Julie Chesné, Faouzi Braza, Antoine Magnan, Gervaise Loirand, Vincent Sauzeau
BACKGROUND: The molecular mechanisms responsible for airway smooth muscle cells (aSMC) contraction and proliferation in airway hyperresponsiveness (AHR) associated with asthma are still largely unknown. The small GTPases of the Rho family (RhoA, Rac1 and Cdc42) play a central role in SMC functions including migration, proliferation and contraction. OBJECTIVE: The objective of this study is to identify the role of Rac1 in aSMC contraction and to investigate its involvement in AHR associated with allergic asthma...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29154116/lanthanum-toxicity-to-five-different-species-of-soil-invertebrates-in-relation-to-availability-in-soil
#2
Jinxia Li, Rudo A Verweij, Cornelis A M van Gestel
This study determined the toxicity of lanthanum, one of the most commonly used rare earth elements (REEs), to five representative soil invertebrates after 3-4 weeks exposure. Toxicity was related to total, 0.01 M CaCl2-extractable and porewater concentrations in the standard LUFA 2.2 soil, and for earthworms also to body concentrations. La sorption to LUFA 2.2 soil, estimated by relating total soil concentrations to CaCl2-extractable or porewater concentrations seemed to reach saturation at >1000 mg La/kg dry soil...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29153274/-classical-and-molecular-methods-for-identification-and-quantification-of-domestic-moulds
#3
REVIEW
E Fréalle, V Bex, G Reboux, S Roussel, S Bretagne
INTRODUCTION: To study the impact of the constant and inevitable inhalation of moulds, it is necessary to sample, identify and count the spores. BACKGROUND: Environmental sampling methods can be separated into three categories: surface sampling is easy to perform but non quantitative, air sampling is easy to calibrate but provides time limited information, and dust sampling which is more representative of long term exposure to moulds. The sampling strategy depends on the objectives (evaluation of the risk of exposure for individuals; quantification of the household contamination; evaluation of the efficacy of remediation)...
November 15, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29150905/sarcoptic-mange-in-wombats-a-review-and-future-research-directions
#4
REVIEW
J M Old, C Sengupta, E Narayan, J Wolfenden
Sarcoptic mange is caused by the mite Sarcoptes scabiei and has recently been recognized as an emerging infectious disease of wildlife worldwide. The mite is one of the main causes of population decline in southern hairy-nosed (Lasiorhinus latifrons) and bare-nosed wombats (Vombatus ursinus). This review focuses on Sarcoptes scabiei infestations in wombats and provides insights into why the disease may be so prevalent in wombats. Current treatment practices and trials conducted in the field to reduce the incidence of sarcoptic mange in wombats are described and critically reviewed...
November 18, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29149780/interleukin-37-relieves-allergic-inflammation-in-a-house-dust-mite-allergic-rhinitis-murine-model
#5
Do Hyun Kim, Si Won Kim, Soo Whan Kim, Jun-Myung Kang
The purpose of this study was to investigate the effects of interleukin-37 (IL-37) on a Dermatophagoides farinae (Der f)-induced murine model of allergic rhinitis (AR). BALB/c mice, except the control groups, were sensitized intraperitoneally and challenged intranasally with Der f (Der f group). The IL-37 and IL-37+anti-CD25 groups were administered IL-37 intranasally. The IL-37+anti-CD25 groups were administered anti-CD25 monoclonal antibody intraperitoneally before challenge. Allergic symptoms and the average eosinophil number were counted...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29148358/all-change%C3%A2-transcanal-endoscopic-ear-surgery-and-house-dust-mite-immunotherapy-for-allergic-rhinitis
#6
Jonathan Fishman, Robin Youngs, Edward Fisher, Musheer Hussain
No abstract text is available yet for this article.
November 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29146574/mast-cell-dependent-il-33-st2-signaling-is-protective-against-the-development-of-airway-hyperresponsiveness-in-a-house-dust-mite-mouse-model-of-asthma
#7
Anna Maria Zoltowska Nilsson, Ying Lei, Mikael Adner, Gunnar P Nilsson
Interleukin-33 (IL-33) and its receptor ST2 have been influentially associated to the pathophysiology of asthma. Due to the divergent roles of IL-33 in regulating mast cell functions, there is a need to further characterize IL-33/ST2-dependent mast cell responses and their significance in the context of asthma. This study aimed to investigate how IL-33/ST2-dependent mast cell responses contribute to the development of airway hyperresponsiveness (AHR) and airway inflammation in a mouse model of house dust mite (HDM) induced asthma...
November 16, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29146015/tablet-based-sublingual-immunotherapy-for-respiratory-allergy
#8
REVIEW
L Prieto
Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Sublingual immunotherapy (SLIT) tablets are now available for grass- or ragweed-induced rhinoconjunctivitis and will be available in Spain for house dust mite (HDM)-induced rhinoconjunctivitis and asthma in the next months...
November 13, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29145825/assembling-large-genomes-analysis-of-the-stick-insect-clitarchus-hookeri-genome-reveals-a-high-repeat-content-and-sex-biased-genes-associated-with-reproduction
#9
Chen Wu, Victoria G Twort, Ross N Crowhurst, Richard D Newcomb, Thomas R Buckley
BACKGROUND: Stick insects (Phasmatodea) have a high incidence of parthenogenesis and other alternative reproductive strategies, yet the genetic basis of reproduction is poorly understood. Phasmatodea includes nearly 3000 species, yet only the genome of Timema cristinae has been published to date. Clitarchus hookeri is a geographical parthenogenetic stick insect distributed across New Zealand. Sexual reproduction dominates in northern habitats but is replaced by parthenogenesis in the south...
November 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29145627/bacterial-communities-associated-with-the-ectoparasitic-mites-varroa-destructor-and-tropilaelaps-mercedesae-of-honey-bees-apis-mellifera
#10
Chonthicha Pakwan, Martin Kaltenpoth, Benjamin Weiss, Panuwan Chantawannakul, Guo Jun, Terd Disayathanoowat
Varroa and Tropilaelaps mites have been reported as serious ectoparasites of honey bees (Apis mellifera). In this study, bacterial communities associated with Varroa destructor and Tropilaelaps mercedesae from Northern Thailand were determined, using both culture-dependent and culture-independent approaches. Adult female mites were collected from apiaries in Chiang Mai and Lampang provinces. Culturable bacteria were isolated from individual mites. On average, we observed approximately 1340 and 1140 CFU/mite in Varroa and Tropilaelaps, respectively...
November 14, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29137399/molecular-characteristics-and-serodiagnostic-potential-of-chitinase-like-protein-from-sarcoptes-scabiei
#11
Ran He, Nengxing Shen, Haojie Zhang, Yongjun Ren, Manli He, Jing Xu, Cheng Guo, Yue Xie, Xiaobin Gu, Weimin Lai, Xuerong Peng, Guangyou Yang
Scabies, caused by the mite Sarcoptes scabiei, is an allergic skin disease that affects millions of people and other mammals worldwide. This highly contagious parasitic disease is among the top 50 epidemic disease and is regarded as a neglected tropical disease. Diagnosis of scabies is difficult in the early stage, and the pathogenesis of scabies is not currently clear. Here, we expressed, identified and located the chitinase-like protein of S. scabiei (SsCLP), and evaluated its potential as an early-stage diagnostic antigen for rabbit scabies...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136456/the-intimate-talk-between-plants-and-microorganisms-at-the-leaf-surface
#12
Wendy Aragón, José Juan Reina-Pinto, Mario Serrano, Eva Dominguez
The plant epidermis or cuticle is constantly exposed to external and internal environmental factors, including an enriched and diverse community of bacteria, yeast, fungi, viruses, and mites. It is not only where the plant has its first physical barrier, but also where organisms can be recognized and potentially where the plant defense responses can be triggered. The plant cuticle is a polymeric composite formed by an array of structurally and chemically heterogeneous compounds, including cutin and wax. A few studies have shown that cuticular components are essential and important drivers of the structure and size of the bacterial community...
November 9, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29136347/pro-inflammatory-mediator-responses-from-neonatal-airway-epithelial-cells-and-early-childhood-wheeze
#13
Steve Turner, David Miller, Garry M Walsh, Alison Scaife, Ultan F Power, Michael D Shields, Graham Devereux
BACKGROUND: Airway epithelial cell (AEC) function differs between children with and without asthma. Here, we associated neonatal AEC function with asthma symptoms at 4 years of age. METHODS: Nasal AEC were collected from neonates within 48 h of birth. Cells were cultured and stimulated with tumor necrosis factor alpha/interleukin-1 beta (TNFα/IL-1β), lipopolysaccharide (LPS), or house dust mite (HDM). Absolute concentrations of pro-inflammatory mediators in the culture supernatant were quantified and expressed as median [interquartile range] in pg/mg protein...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29135514/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-to-house-dust-mites
#14
Yoo Seob Shin, Chang-Gyu Jung, Hae-Sim Park
PURPOSE OF REVIEW: Local allergic rhinitis (LAR) is a recently classified subtype of rhinitis defined by a nasal allergic response in patients without systemic evidence of atopy. Recent studies have reported the prevalence, clinical course, culprit allergens, diagnostic methods and treatment outcomes of LAR. The purpose of this review is to summarize the most relevant and updated scientific evidence for LAR, especially focusing on its prevalence and clinical characteristics. RECENT FINDINGS: LAR is found in a significant proportion (3...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132960/influenza-derived-peptides-cross-react-with-allergens-and-provide-asthma-protection
#15
Chrysanthi Skevaki, Christoph Hudemann, Mikhail Matrosovich, Christian Möbs, Sinu Paul, Andreas Wachtendorf, Bilal Alashkar Alhamwe, Daniel P Potaczek, Stefanie Hagner, Diethard Gemsa, Holger Garn, Alessandro Sette, Harald Renz
BACKGROUND: The hygiene hypothesis is the leading concept to explain the current asthma epidemic, which is built on the observation that a lack of bacterial contact early in life induces allergic Th2 immune responses. OBJECTIVE: Since little is known about the contribution of respiratory viruses in this context, we evaluated the effect of prior influenza-infection on the development of allergic asthma. METHODS: Mice were infected with influenza and once recovered, subjected to an ovalbumin or house dust mite-induced experimental asthma protocol...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132467/-distribution-characteristics-of-serum-specific-ige-for-inhaled-allergens-in-children-with-different-airway-allergic-diseases
#16
Kang Zhu, Xiao-Ling Hou, Hui-Jie Huang, Ya-Ru Wang, Yi-Xin Ren, Xin Ni, Li Xiang
OBJECTIVE: To investigate the distribution characteristics of serum specific IgE (sIgE) for inhaled allergens in children with different airway allergic diseases. METHODS: Fluorescent enzyme-linked immunosorbent assay on the UniCAP250 system was performed to measure serum sIgE for 9 common inhaled allergens in 256 children aged 3-14 years with different airway allergic diseases. According to the clinical diagnosis, these children were divided into rhinitis group (37 children with allergic rhinitis), asthma group (82 children with bronchial asthma), and rhinitis-asthma group (137 children with allergic rhinitis complicated by bronchial asthma)...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29131267/interleukin-33-promotes-the-inflammatory-reaction-in-chronic-rhinosinusitis-with-nasal-polyps-by-nf-%C3%AE%C2%BAb-signaling-pathway
#17
L Zhang, L-L Jiang, Z-W Cao
OBJECTIVE: Interleukin (IL)-33 promotes T helper (Th2) immune response and may be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Using murine and human specimens, we evaluated the role of IL-33 in CRSwNP. MATERIALS AND METHODS: To establish CRSwNP, Balb/c mice were sensitized with house dust mite, followed up by intranasal exposure to Staphylococcus aureus to stimulate the inflammatory response of nasal mucosa. The hematoxylin-eosin staining and total serum IgE were used to the successful construction of CRSwNP model...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29130983/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-in-children-sensitized-to-house-dust-mites
#18
Eun Kyo Ha, Min Sun Na, Shinhae Lee, Heysung Baek, Seung Jin Lee, Youn Ho Sheen, Young-Ho Jung, Kyung Suk Lee, Mi Ae Kim, Hye Mi Jee, Man Yong Han
OBJECTIVE: The prevalence of local allergic rhinitis (LAR) in nonatopic children remains unknown. This study aimed to determine the prevalence, clinical characteristics, and severity of LAR in children in comparison to classical allergic rhinitis (AR) and nonallergic rhinitis (NAR). STUDY DESIGN: A total of 145 children (aged 1-18 years) were enrolled and classified into 3 groups (AR, NAR, and LAR) based on a skin prick test (SPT) and a nasal provocation test (NPT) with house dust mite, i...
November 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29130801/the-relevance-of-house-dust-mites-allergy-in-clinical-practice-the-epidemiological-impact-on-allergen-immunotherapy
#19
Giorgio Ciprandi, Paola Puccinelli, Cristoforo Incorvaia, Giovanni Passalacqua
House dust mite (HDM) is the most common cause of respiratory allergy worldwide. The impact of HDM allergy is influenced by a number of factors, including local climate. We investigated such issue in Italy, using a real-life setting, including outpatients visited at allergy clinics. In 9143 patients (7873 adults and 1270 children) who were evaluated in 15 allergy clinics, investigating as well the rate of prescription of allergen immunotherapy. The present study confirms that Mediterranean climate is associated with a higher prevalence of mite allergy than continental climate...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29130795/comparison-of-two-different-assays-and-the-predictive-value-of-allergen-components-in-house-dust-mite-allergy
#20
Johannes Schulze, Lisanne Leberkuehne, Emilia Salzmann-Manrique, Ralf Schubert, Stefan Zielen, Martin Rosewich
AIM: In house dust mite (HDM) allergy diagnostics, the IMMULITE, ImmunoCAP and assays for allergen components (nDer p 1 and rDer p 2) are available. METHODS: Serum sIgE levels were compared and the predictive values for the detection of an early asthmatic response (EAR) were calculated with receiver operating characteristics and a log-logistic regression model. RESULTS: sIgE levels of IMMULITE and ImmunoCAP were similar (Dermatophagoides pteronyssinus [D...
November 2017: Immunotherapy
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