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Simulation traing

My-Tra Le, Wojciech K Kasprzak, Taejin Kim, Feng Gao, Megan Yl Young, Xuefeng Yuan, Bruce A Shapiro, Joonil Seog, Anne E Simon
Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to undergo a conformational shift postulated to inhibit translation. Using optical tweezers (OT) and steered molecular dynamic simulations (SMD), we found that the unusual stability of pseudoknotted element H4a/Ψ3 required five upstream adenylates, and H4a/Ψ3 was necessary for cooperative association of two other hairpins (H5/H4b) in Mg(2+)...
February 13, 2017: ELife
Dustin L Crouch, He Huang
Simple, lumped-parameter musculoskeletal models may be more adaptable and practical for clinical real-time control applications, such as prosthesis control. In this study, we determined whether a lumped-parameter, EMG-driven musculoskeletal model with four muscles could predict wrist and metacarpophalangeal (MCP) joint flexion/extension. Forearm EMG signals and joint kinematics were collected simultaneously from 5 able-bodied (AB) subjects. For one subject with unilateral transradial amputation (TRA), joint kinematics were collected from the sound arm during bilateral mirrored motion...
December 8, 2016: Journal of Biomechanics
Didem Öner Özdaş, Mağrur Kazak, Aylin Çilingir, Meryem Gülce Subaşı, Murat Tiryaki, Şölen Günal
BACKGROUND: Although most of the studies investigated color stability of different restorative materials, evaluation of color stability of composites after immersion in multiple beverages in the same day by an in vitro oral simulation study is unclear. OBJECTIVE: To assess color change of different restorative materials at the end of days 1, 14, and 30 of immersion in multiple liquid types to mimic the oral environment in vitro. METHOD: Ten disc-shaped specimens were made from each of four different resin composites (Filtek Z250, Voco x-tra base, Beautifil Flow Plus, Beautifil II)...
2016: Open Dentistry Journal
M Retournard, A Bilmont, E Asimus, S Palierne, A Autefage
The effects of Tibial Tuberosity Advancement (TTA) on Cranial Tibial Subluxation (CTS) and Tibial Rotation Angle (TRA) were evaluated in a model of feline Cranial Cruciate Ligament (CrCL)-deficient stifle joint. Ten hindlimbs of adult cats were used. Quadriceps and gastrocnemius muscles were simulated using cables, turnbuckles and a spring. An axial load of 30% body weight was applied. The stifle and talocrural joint angles were adjusted to 120°. Patellar tendon angle (PTA), CTS and TRA were measured radiographically before and after CrCL section, after TTA and after additional advancement by 1 and 2mm...
August 2016: Research in Veterinary Science
Kazutoyo Miura, Bruce J Swihart, Bingbing Deng, Luwen Zhou, Thao P Pham, Ababacar Diouf, Timothy Burton, Michael P Fay, Carole A Long
Malaria transmission-blocking vaccines (TBVs) are potentially helpful tools for malaria eradication. The standard membrane-feeding assay (SMFA) is considered one of the "gold standard" assays for TBV development. However, lack of consensus in reporting results from SMFA has made it very challenging to compare results from different studies. Two main readouts, % inhibition in mean oocyst count per mosquito (TRA) and % inhibition in prevalence of infected mosquitoes (TBA), have been used widely. In this study, we statistically modeled the oocyst data in SMFA using data from 105 independent feeding experiments including 9804 mosquitoes...
July 29, 2016: Vaccine
Tobias T Tauböck, Zrinka Tarle, Danijela Marovic, Thomas Attin
OBJECTIVES: To investigate the influence of pre-heating of high-viscosity bulk-fill composite materials on their degree of conversion and shrinkage force formation. METHODS: Four bulk-fill composite materials (Tetric EvoCeram Bulk Fill-TECBF, x-tra fil-XF, QuixFil-QF, SonicFill-SF) and one conventional nano-hybrid resin composite (Tetric EvoCeram-TEC) were used. The test materials were either kept at room temperature or pre-heated to 68°C by means of a commercial heating device, before being photoactivated with a LED curing unit for 20s at 1170mW/cm(2)...
November 2015: Journal of Dentistry
Shruti A Vidhawan, Adrian U Yap, Barbara P Ornaghi, Agnieszka Banas, Krzysztof Banas, Jennifer C Neo, Carmem S Pfeifer, Vinicius Rosa
OBJECTIVES: The aim of this study was to determine the Weibull and slow crack growth (SCG) parameters of bulk-fill resin based composites. The strength degradation over time of the materials was also assessed by strength-probability-time (SPT) analysis. METHODS: Three bulk-fill [Tetric EvoCeram Bulk Fill (TBF); X-tra fil (XTR); Filtek Bulk-fill flowable (BFL)] and a conventional one [Filtek Z250 (Z250)] were studied. Seventy five disk-shaped specimens (12mm in diameter and 1mm thick) were prepared by inserting the uncured composites in a stainless steel split mold followed by photoactivation (1200mW/cm(2)/20s) and storage in distilled water (37°C/24h)...
September 2015: Dental Materials: Official Publication of the Academy of Dental Materials
Ying Wang, Bin-Kuan Chou, Sarah Dowey, Chaoxia He, Sharon Gerecht, Linzhao Cheng
Large-scale production of human induced pluripotent stem cells (hiPSCs) by robust and economic methods has been one of the major challenges for translational realization of hiPSC technology. Here we demonstrate a scalable culture system for hiPSC expansion using the E8 chemically defined and xeno-free medium under either adherent or suspension conditions. To optimize suspension conditions guided by a computational simulation, we developed a method to efficiently expand hiPSCs as undifferentiated aggregates in spinner flasks...
November 2013: Stem Cell Research
Hanadi Y Marghalani, David C Watts
OBJECTIVE: To study time-dependent viscoelastic deformation (creep and recovery) of resin-composites, after conditioning in food-simulating solvents, under a compressive stress at 37°C. METHODS: Five dimethacrylate-based composites: (Spectrum TPH, Premise Body, Tetric Ceram HB, Filtek P60, X-tra fil), and two Ormocers (Experimental Ormocer V 28407, Admira) were studied. Three groups of cylindrical specimens (4mm×6mm) were prepared and then conditioned in 3 solvents: methyl ethyl ketone (MEK), ethanol, and water for 1 month at 37°C...
September 2013: Dental Materials: Official Publication of the Academy of Dental Materials
Wei Jie Jensen Ang, Michael Edward Hopkins, Roland Partridge, Iain Hennessey, Paul Martin Brennan, Ioannis Fouyas, Mark Antony Hughes
BACKGROUND: Reductions in working hours affect training opportunities for surgeons. Surgical simulation is increasingly proposed to help bridge the resultant training gap. For simulation training to translate effectively into the operating theater, acquisition of technical proficiency must be objectively assessed. Evaluating "economy of movement" is one way to achieve this. OBJECTIVE: We sought to validate a practical and economical method of assessing economy of movement during a simulated task...
March 2014: Neurosurgery
Agnese Miro, Ivana d'Angelo, Antonella Nappi, Pietro La Manna, Marco Biondi, Laura Mayol, Pellegrino Musto, Roberto Russo, Maria Immacolata La Rotonda, Francesca Ungaro, Fabiana Quaglia
Inspired by the multiple roles cyclodextrins can play in polymeric systems, here we engineered poly(ethylene oxide) (PEO) films with (2-hydroxypropyl)-β-cyclodextrin (CD) as multipurpose ingredient. To shed light on the potential of CD in formulating PEO buccal films for the delivery of poorly water-soluble drugs, we preliminarily assessed thermal and mechanical properties as well as wettability of films prepared at different PEO/CD ratios. PEO/CD platform containing 54% by weight of CD was chosen as the optimized composition since it matched acceptable mechanical properties, in terms of tensile strength and elasticity, with a good wettability...
August 16, 2013: International Journal of Pharmaceutics
Nicoleta Ilie, Andreas Keßler, Jürgen Durner
OBJECTIVES: To assess the effect of irradiation time and distance of the light tip on the micro-mechanical properties and polymerisation kinetics of two bulk-fill resin-based composites at simulated clinically relevant filling depth. METHODS: Micro-mechanical properties (Vickers hardness (HV), depth of cure (DOC) and indentation modulus (E)) and polymerisation kinetics (real-time increase of degree of cure (DC)) of two bulk-fill resin-based composites (Tetric EvoCeram(®) Bulk Fill, Ivoclar Vivadent and x-tra base, Voco) were assessed at varying depth (0...
August 2013: Journal of Dentistry
Mark G Orr, Roxanne Thrush, David C Plaut
The reasoned action approach, although ubiquitous in health behavior theory (e.g., Theory of Reasoned Action/Planned Behavior), does not adequately address two key dynamical aspects of health behavior: learning and the effect of immediate social context (i.e., social influence). To remedy this, we put forth a computational implementation of the Theory of Reasoned Action (TRA) using artificial-neural networks. Our model re-conceptualized behavioral intention as arising from a dynamic constraint satisfaction mechanism among a set of beliefs...
2013: PloS One
Cedric Robert, Tra Nguyen Thanh, Charles Cornet, Pascal Turban, Mathieu Perrin, Andrea Balocchi, Herve Folliot, Nicolas Bertru, Laurent Pedesseau, Mikhail O Nestoklon, Jacky Even, Jean-Marc Jancu, Sylvain Tricot, Olivier Durand, Xavier Marie, Alain Le Corre
(In,Ga)As/GaP(001) quantum dots (QDs) are grown by molecular beam epitaxy and studied both theoretically and experimentally. The electronic band structure is simulated using a combination of k·p and tight-binding models. These calculations predict an indirect to direct crossover with the In content and the size of the QDs. The optical properties are then studied in a low-In-content range through photoluminescence and time-resolved photoluminescence experiments. It suggests the proximity of two optical transitions of indirect and direct types...
2012: Nanoscale Research Letters
Rosana M Lobayan, María C Pérez Schmit, Alicia H Jubert, Arturo Vitale
The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Moreover, TRA, and other indolic compounds are very efficient antioxidants. In this work the conformational space of TRA was scanned in aqueous solution, simulating the solvent by the polarizable continuum model. Geometry optimizations were performed at B3LYP/6-31+G** level...
March 2013: Journal of Molecular Modeling
Vilma Pinchi, Gian-Aristide Norelli, Fabio Caputi, Gianfranco Fassina, Francesco Pradella, Cecilia Vincenti
Dental forensic identifications based on comparison of antemortem and postmortem radiographs provide effective and reliable evidence. There are no standardized procedures for assessing similarities between different types of dental radiographs (e.g. orthopantomograms, bitewings, and periapical radiographs), and the operator's subjective judgment can considerably affect identification. The purpose of this study is to evaluate the potential influence of experts' qualifications, training, and cognitive bias on the accuracy of identification...
October 10, 2012: Forensic Science International
Rosana M Lobayan, María C Pérez Schmit, Alicia H Jubert, Arturo Vitale
UNLABELLED: Due to the free radical scavenger properties of Tryptamine (TRA), as well as of others indole derivatives, it is in our interest to explore deeply the stereoelectronic aspects that would be relevant in their stabilization and antioxidant activity. In this work the conformational space of TRA was scanned using molecular dynamics complemented with functional density calculations at B3LYP/6-31 + G** level. Twenty one conformers of lowest energy were obtained, their electronic distributions were analyzed at a higher calculation level, thus improving the basis set (B3LYP/6-311++G**)...
June 2012: Journal of Molecular Modeling
Jodie Hyde, Warren R Stanton, Julie A Hides
The aim of this study was to examine the automatic recruitment of the deep abdominal muscles during a unilateral simulated weight-bearing task by elite Australian Rules football (AFL) players with and without low back pain (LBP). An observational cross-sectional study was conducted using ultrasound imaging to measure the thickness of the internal oblique (IO) and transversus abdominis (TrA) muscles. Thirty-seven elite male AFL players participated. Repeated measures factors included 'force level' (rest, 25% and 45% of body weight), 'leg' (dominant or non-dominant kicking leg) and 'side' (ultrasound side ipsilateral or contralateral to the leg used for the weight-bearing task)...
February 2012: Human Movement Science
Hongtao Zhao, Xuyong Li, Xiaomei Wang
Understanding the contribution of road-deposited sediment (RDS) and its washoff process is essential for controlling urban runoff pollution. Ninety-seven RDS samples were collected along the urban-suburban-rural gradient from areas of five administrative units in the Beijing metropolitan region, including central urban (UCA), urban village (UVA), central suburban county (CSA), rural town (RTA), and rural village (RVA) areas. RDS washoff was evaluated with different particle sizes using a rainfall simulator...
September 1, 2011: Environmental Science & Technology
Eduard Resch, Jan A Hiss, Alexander Schreiner, Gisbert Schneider, Anna Starzinski-Powitz
Targeting of proteins to the endoplasmic reticulum (ER) usually requires N-terminal signal peptides (SP) of approximately 22 amino acids in length. However, a substantial number of proteins contain exceptionally long SPs of 40 amino acids and more, an example being protein shrew-1/AJAP1. Using shrew-1's SP as example, the NtraC model has been developed by dissecting long SPs into two functionally distinct subdomains ("N" and "C") separated by a β-turn rich transition area ("tra"). Further proteins have been identified by computational analysis complying with the NtraC model...
March 2011: Molecular BioSystems
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