keyword
MENU ▼
Read by QxMD icon Read
search

Anabolic steroids

keyword
https://www.readbyqxmd.com/read/29791601/resting-spontaneous-baroreflex-sensitivity-and-cardiac-autonomic-control-in-anabolic-androgenic-steroid-users
#1
Marcelo R Dos Santos, Ana L C Sayegh, Rafael Armani, Valéria Costa-Hong, Francis R de Souza, Edgar Toschi-Dias, Luiz A Bortolotto, Mauricio Yonamine, Carlos E Negrão, Maria-Janieire N N Alves
OBJECTIVES: Misuse of anabolic androgenic steroids in athletes is a strategy used to enhance strength and skeletal muscle hypertrophy. However, its abuse leads to an imbalance in muscle sympathetic nerve activity, increased vascular resistance, and increased blood pressure. However, the mechanisms underlying these alterations are still unknown. Therefore, we tested whether anabolic androgenic steroids could impair resting baroreflex sensitivity and cardiac sympathovagal control. In addition, we evaluate pulse wave velocity to ascertain the arterial stiffness of large vessels...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29790034/left-atrial-myocardial-dysfunction-after-chronic-abuse-of-anabolic-androgenic-steroids-a-speckle-tracking-echocardiography-analysis
#2
Antonello D'Andrea, Juri Radmilovic, Stefano Caselli, Andreina Carbone, Raffaella Scarafile, Simona Sperlongano, Gianpaolo Tocci, Tiziana Formisano, Francesca Martone, Biagio Liccardo, Michele D'Alto, Eduardo Bossone, Maurizio Galderisi, Paolo Golino
Anabolic-androgenic steroids (AAS) are used by power athletes to improve performance. However, the real effects of the chronic consumption of AAS on cardiovascular structures are subjects of intense debate. To detect by speckle tracking echocardiography (STE) underlying left atrial (LA) dysfunction in athletes abusing AAS and assess possible correlation between LA myocardial function and exercise capacity during cardiopulmonary stress test. 65 top-level competitive bodybuilders were selected (45 males), including 35 athletes misusing AAS for at least 5 years (users), 30 anabolic-free bodybuilders (non-users), compared to 40 age- and sex-matched healthy sedentary controls...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29787833/dehydroepiandrosterone-molecular-mechanisms-and-therapeutic-implications-in-osteoarthritis
#3
REVIEW
Kai Huang, Li-Dong Wu
Dehydroepiandrosterone (DHEA), a 19-carbon steroid hormone primarily synthesized in the adrenal gland, exerts a chondroprotective effect against osteoarthritis (OA) and has been considered an effective candidate of disease-modifying OA drugs (DMOADs) that slow disease progression. We and others previously demonstrated that DHEA exerted a beneficial effect on osteoarthritic cartilage by positively modulating the balance between anabolic and catabolic factors (e.g., MMPs/TIMP-1, ADAMTS/TIMP-3 and cysteine proteinases/cystatin C), inhibiting catabolic signaling pathways (e...
May 19, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29782843/role-of-nutritional-vitamin-d-in-osteoporosis-treatment
#4
REVIEW
Yi-Chou Hou, Chia-Chao Wu, Min-Tser Liao, Jia-Fwu Shyu, Chi-Feng Hung, Tzung-Hai Yen, Chien-Lin Lu, Kuo-Cheng Lu
Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and microarchitectural deterioration of bone tissue. The World Health Organization has defined osteoporosis as a decrease in bone mass (50%) and bony quality (50%). Vitamin D, a steroid hormone, is crucial for skeletal health and in mineral metabolism. Its direct action on osteoblasts and osteoclasts and interaction with nonskeletal tissues help in maintaining a balance between bone turnover and bone growth. Vitamin D affects the activity of osteoblasts, osteoclasts, and osteocytes, suggesting that it affects bone formation, bone resorption, and bone quality...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29766657/drug-drug-interaction-and-doping-effect-of-non-prohibited-drugs-on-the-urinary-excretion-profile-of-methandienone
#5
Monica Mazzarino, Franziska L Khevenhüller-Metsch, Ilaria Fiacco, Maria Kristina Parr, Xavier de la Torre, Francesco Botrè
The potential consequences of drug-drug interactions on the excretion profile of the anabolic androgenic steroid methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one) are discussed here. More specifically, we have evaluated by in vitro and in vivo experiments the effects of seven non-prohibited drugs (fluconazole, ketoconazole, itraconazole, miconazole, fluoxetine, paroxetine and nefazodone) on the main metabolic pathways of methandienone. These are selected among those most commonly used by the athletes...
May 15, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29766147/the-non-preventive-effects-of-human-menopausal-gonadotropins-on-ovarian-tissues-in-nandrolone-decanoate-treated-female-rats-a-histochemical-and-ultra-structural-study
#6
Fakhroddin Mesbah, Hossein Bordbar, Tahereh Talaei Khozani, Farzaneh Dehghani, Hossein Mirkhani
Background: The follicular growth and development may be affected by abused drugs. Nandrolone decanoate (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive failure. Objective: This study was designed to evaluate the effects of synchronized and non-synchronized administration of Human Menopausal Gonadotropins (hMG) with ND on ovarian tissue and level of sex hormones in the adult female rat...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29759662/nandrolone-decanoate-and-physical-activity-affect-quadriceps-in-peripubertal-rats
#7
Jasmina Sretenovic, Vladimir Ajdzanovic, Vladimir Zivkovic, Ivan Srejovic, Milena Corbic, Verica Milosevic, Vladimir Jakovljevic, Zoran Milosavljevic
Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone often used by athletes to increase the skeletal muscle mass. Our goal was to examine the effects of physical activity and physical activity combined with supraphysiological doses of nandrolone on functional morphology of the quadriceps muscle. The study included 32 peripubertal Wistar rats, divided into 4 groups: control (T-N-), nandrolone (T-N+), physical activity (T+N-) and physical activity plus nandrolone (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 h/day, 5 days/week...
May 11, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29757501/important-considerations-for-the-utilisation-of-methanolysis-in-steroid-analysis
#8
Marjaana Viljanto, Catarina Horro Pita, James Scarth, Christopher J Walker, Andrew T Kicman, Mark C Parkin
The effective analysis of anabolic-androgenic steroids in urine usually requires a suitable deconjugation method for the analysis of phase II metabolites such as sulfates and glucuronides. Acid hydrolysis using methanolysis is one adopted method of deconjugation that efficiently and rapidly cleaves both sulfates and glucuronides contemporaneously. The formation of artefactual by-products is a known disadvantage of this harsh method. However, the possible promotion of deuterium-hydrogen exchange of isotopically labelled internal standards has received little attention in the literature...
May 14, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29731530/noble-metal-nanostructures-in-optical-biosensors-basics-and-their-introduction-to-anti-doping-detection
#9
Hedieh Malekzad, Parham Sahandi Zangabad, Hadi Mohammadi, Mohsen Sadroddini, Zahra Jafari, Niloofar Mahlooji, Somaye Abbaspour, Somaye Gholami, Mana Ghanbarpoor, Rahim Pashazadeh, Ali Beyzavi, Mahdi Karimi, Michael R Hamblin
Nanotechnology has illustrated significant potentials in biomolecular-sensing applications; particularly its introduction to anti-doping detection is of great importance. Illicit recreational drugs, substances that can be potentially abused, and drugs with dosage limitations according to the prohibited lists announced by the World Antidoping Agency (WADA) are becoming of increasing interest to forensic chemists. In this review, the theoretical principles of optical biosensors based on noble metal nanoparticles, and the transduction mechanism of commonly-applied plasmonic biosensors are covered...
March 2018: Trends in Analytical Chemistry: TRAC
https://www.readbyqxmd.com/read/29721213/anabolic-androgenic-steroids-and-carcinogenicity-focusing-on-leydig-cell-a-literature-review
#10
REVIEW
Monica Salerno, Orazio Cascio, Giuseppe Bertozzi, Francesco Sessa, Antonietta Messina, Vincenzo Monda, Luigi Cipolloni, Antonio Biondi, Aurora Daniele, Cristoforo Pomara
Anabolic androgenic steroids (AAS) are some of the most common drugs used among athletes, frequently in combination with resistance training, to improve physical performance or for aesthetic purpose. A great number of scientific reports showed the detrimental effects of anabolic androgenic steroids on different organs and tissues. In this literature review, we analyzed the AAS-mediated carcinogenicity, focusing on Leydig cell tumor. AAS-induced carcinogenicity can affect DNA transcription through two pathways...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717770/stanozolol-administration-combined-with-exercise-leads-to-decreased-telomerase-activity-possibly-associated-with-liver-aging
#11
Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N Tzatzarakis, Christina Tsitsimpikou, Polychronis D Stivaktakis, Dimitrios Tsoukalas, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29704771/new-approach-based-on-immunochemical-techniques-for-monitoring-of-selective-estrogen-receptor-modulators-serms-in-human-urine
#12
J-Pablo Salvador, Ester Vila-Roca, Núria Monfort, Rosa Ventura, M-Pilar Marco
Antiestrogenic compounds such as tamoxifen, toremifen and chlomifen are used illegally by athletes to minimize physical impacts such as gynecomastia resulting from the secondary effects of anabolic androgenic steroids, used to increase athletic efficiency unlawfully. The use of these compounds is banned by the World Anti-Doping Agency (WADA) and controls are made through analytical methodologies such as HPLC-MS/MS, which do not fulfil the sample throughput requirements. Moreover, compounds such as tamoxifen are also used to treat hormone receptor-positive breast cancer (ER + )...
April 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29704577/food-drug-interaction-anabolic-steroids-aggravate-hepatic-lipotoxicity-and-nonalcoholic-fatty-liver-disease-induced-by-trans-fatty-acids
#13
Jamili D B Santos, Andrea A S Mendonça, Rafaela C Sousa, Thaiany G S Silva, Solange M Bigonha, Eliziária C Santos, Reggiani V Gonçalves, Romulo D Novaes
Remains unknown if dietary lipids and anabolic steroids (AS) can interact to modify energy metabolism, hepatic structure and function. We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholic fatty liver disease (NAFLD) in mice treated with a diet rich in trans fatty acids. Seventy-two C57BL/6 mice were equally randomized into six groups and treated with a standard diet (SD) or high-fat diet (HFD) alone or combined with testosterone cypionate (10 or 20 mg/kg) for 12 weeks...
April 25, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29702199/androgen-and-estrogen-receptor-mediated-activities-of-4-hydroxytestosterone-4-hydroxyandrostenedione-and-their-human-metabolites-in-yeast-based-assays
#14
Annekathrin Martina Keiler, Oliver Zierau, Sylvi Wolf, Patrick Diel, Wilhelm Schänzer, Günter Vollmer, David Machalz, Gerhard Wolber, Maria Kristina Parr
4-Hydroxyandrost-4-ene-3,17-dione, also named formestane, is an irreversible aromatase inhibitor and therapeutically used as anti-breast cancer medication in post-menopausal women. Currently, no therapeutical indication led to approval of its 17-hydroxylated analog 4-hydroxytestosterone, an anabolic steroid. However, it is currently investigated in a clinical trial for breast cancer. In context with sports doping, aromatase inhibitors are administered to reduce estrogenic side effects of misused anabolic substances or their metabolites...
April 24, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29701261/a-critical-review-of-the-environmental-occurrence-and-potential-effects-in-aquatic-vertebrates-of-the-potent-androgen-receptor-agonist-17%C3%AE-trenbolone
#15
REVIEW
Gerald T Ankley, Katherine K Coady, Melanie Gross, Henrik Holbech, Steven L Levine, Gerd Maack, Mike Williams
Trenbolone acetate is widely-used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β-trenbolone (βTRB), have been detected in at low ng/L concentrations in surface waters associated with animal feedlots. The βTRB isomer can affect androgen receptor (AR) signaling pathways in various vertebrate species at comparatively low concentrations/doses. This paper provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of βTRB, with an emphasis on potential risks to aquatic animals...
April 27, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29687691/side-effects-of-anabolic-steroids-used-by-athletes-at-unaizah-gyms-saudi-arabia-a-pilot-study
#16
Amer A Almaiman, Sulaiman H Almaiman, Elsayed I Elagamy, Osama Al Wutayd, Mohammed Almarzuqi, Rayyan Alzunaidi, Sami Alhatlani, Eltayeb E Eid
BACKGROUND: A large number of Saudi athletes are recently shown to use androgenic anabolic steroid (AAS) products to achieve rapid muscle growth without realizing the serious health risks of these drugs. Aim of this study was to elucidate the side effects encountered with prolonged use of AAS products by Saudi athletes. METHODS: A cross-sectional study was conducted, in which 16 regular gym members, 12 of them used AAS, were asked to answer a questionnaire and provide blood samples following current AAS course completion...
April 20, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29684910/forensic-applications-of-supercritical-fluid-chromatography-mass-spectrometry
#17
REVIEW
Volodymyr Pauk, Karel Lemr
Achievements of supercritical fluid chromatography with mass spectrometric detection made in the field of forensic science during the last decade are reviewed. The main topics include analysis of traditional drugs of abuse (e.g. cannabis, methamphetamine) as well as new psychoactive substances (synthetic cannabinoids, cathinones and phenethylamines), doping agents (anabolic steroids, stimulants, diuretics, analgesics etc.) and chemical warfare agents. Control of food authenticity, detection of adulteration and identification of toxic substances in food are also pointed out...
April 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29670477/prevalence-attitude-knowledge-and-practice-of-anabolic-androgenic-steroid-aas-use-among-gym-participants
#18
Sami D Althobiti, Nassar M Alqurashi, Abdulmajeed S Alotaibi, Turki F Alharthi, Khaled A Alswat
Background: Anabolic steroids (AS) are synthetic testosterone derivatives that last longer than physiological androgens in the body. Anabolic-androgenic steroid (AAS) abuse is spreading among athletes. The aim of this study is to assess the knowledge, attitudes, and practices of gym participants in Saudi Arabia. Methods: A cross-sectional survey was carried out among gym users from February 2017 to May 2017. The questionnaire included information on demographics related to the use of AAS and lifestyle habits...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29660668/supercritical-fluid-chromatography-applied-to-the-highly-selective-isolation-of-urinary-steroid-hormones-prior-to-gc-ms-analysis
#19
Mickael Doué, Caroline West, Emmanuelle Bichon, Bruno Le Bizec, Eric Lesellier
To assess the presence of prohibited anabolic substances used to promote growth in livestock, calf urine is the most relevant matrix. However, the sample preparation methods (required to remove unwanted matrix components and fractionate isobaric species that may be unresolved by gas chromatography- mass spectrometry GC/MS) are long and complex. In this context, semi-preparative supercritical fluid chromatography (SFC) was considered to possibly simplify the sample preparation in reducing the number of procedures...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29657200/complementary-bodybuilding-a-potential-risk-for-permanent-kidney-disease
#20
Wael El-Reshaid, Kamel El-Reshaid, Shaikha Al-Bader, Ahmad Ramadan, John Patrick Madda
We report our experience of renal disease associated with bodybuilders who had been on high-protein diet, anabolic androgenic steroids (AASs), and growth hormone (GH) for years. A total of 22 adult males who volunteered information about use of high protein diet and AAS or GH were seen over a six-year period with renal disease. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS) in eight, nephroangiosclerosis in four, chronic interstitial nephritis in three, acute interstitial nephritis in two, nephrocalcinosis with chronic interstitial nephritis in two, and single patients with membranous glomerulopathy, crescentic glomerulopathy, and sclerosing glomerulonephritis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
keyword
keyword
1239
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"