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https://www.readbyqxmd.com/read/28728300/-evaluate-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-mutationsin-epidermal-growth-factor-receptor-in-lung-adenocarcinoma
#1
C Y Ding, W P Yang, Z Guo, J Sun, Y Y Li, T R Li
Objective: To investigate the value of maximum Standardized Uptake Value(SUVmax), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG) calculated from (18)F-FDG PET-CT in predicting the presence of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma. Methods: We retrospectively reviewed 137 lung adenocarcinoma patients with EGFR mutations testing and pretreatment (18)F-FDG PET-CT. Receiver Operating Characteristic (ROC) curve analysis was performed to quantify the predictive value of SUVmax、MTV、TLG...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28728208/the-role-of-18f-fdg-pet-ct-scan-in-predicting-histological-type-of-thymic-epithelial-tumors-indications-and-practical-clinical-considerations
#2
Filippo Lococo
No abstract text is available yet for this article.
July 20, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28725988/interim-18-f-fgd-pet-ct-may-not-predict-the-outcome-in-primary-central-nervous-system-lymphoma-patients-treated-with-sequential-treatment-with-methotrexate-and-cytarabine
#3
Jae-Cheol Jo, Dok Hyun Yoon, Shin Kim, Kyoungmin Lee, Eun Hee Kang, Jung Sun Park, Jin-Sook Ryu, Jooryung Huh, Chan-Sik Park, Jong Hoon Kim, Sang Wook Lee, Cheolwon Suh
(18)F-fluoro-2-dexoy-D-glucose-positron emission tomography (PET)/computed tomography (CT) is a useful imaging technique for monitoring the treatment response in lymphoma cases. We investigated the value of interim brain PET/CT (I-PET/CT) for monitoring the response to intensive methotrexate-based chemotherapy in primary central nervous system lymphoma (PCNSL) patients with diffuse large B cell lymphoma (DLBCL). Of the 76 PCNSL patients treated with intensive methotrexate and cytarabine chemotherapy between September 2006 and December 2012, 66 patients with DLBCL were included in this study...
July 19, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28723740/case-report-multiple-systemic-disseminated-tuberculosis-mimicking-lymphoma-on-18f-fdg-pet-ct
#4
Shasha Hou, Jie Shen, Jian Tan
RATIONALE: F-fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) has an important role in the diagnosis of various malignancies. However, F-18 FDG can also exhibit intense accumulation in tissues in inflammatory conditions such as active tuberculosis (TB) and sarcoidosis. PATIENT CONCERNS: We report a case of a 52-year-old female with irritable cough. CT showed a lung mass with multiple bilateral lung nodules, and sarcoidosis was suspected...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723716/refining-the-management-of-patients-with-hepatocellular-carcinoma-integrating-11c-choline-pet-ct-scan-into-the-multidisciplinary-team-discussion
#5
Ezio Lanza, Matteo Donadon, Paolo Felisaz, Antonio Mimmo, Arturo Chiti, Guido Torzilli, Luca Balzarini, Egesta Lopci
OBJECTIVE: The aim of this study was to report the impact of C-choline PET/CT on the management of patients with hepatocellular carcinoma (HCC) and incorporate into a refined algorithm combining diagnostic imaging and multidisciplinary team (MDT) discussion. PATIENTS AND METHODS: From February 2010 to February 2016, the charts of all patients discussed in the liver MDT were revised. Suspected or confirmed HCC lesions or Barcelona Clinic Liver Cancer stages A, B or C with a C-choline PET/CT performed in our hospital were included in the analyses...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28723715/novel-weight-based-dose-threshold-for-18f-naf-pet-ct-imaging-using-advanced-pet-ct-systems-a-potential-tool-for-reducing-radiation-burden
#6
Fahad Marafi, Abdulreda Esmail, Rashid Rasheed, Fareeda Alkandari, Sharjeel Usmani
BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer. Besides traditional dose metrics, recent methods such as real-time dose mapping, dose calculation from DICOM information, and their relevance to entrance skin exposure are currently in use to reduce the radiation burden. In this study, we have analyzed the data of 1062 patients retrospectively to evaluate patterns of absorbed dose for institutional weight-based dose protocol as compared with fixed dose method guidelines of Society of Nuclear Medicine and Molecular Imaging (SNMMI)...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28722086/-current-surgical-strategy-of-locally-recurrent-rectal-cancer
#7
Xin Wang, Yong Jiang
The incidence of locally recurrent rectal cancer (LRRC) is less than 10% following treatment for primary rectal cancer, while LRRC usually has serious symptoms and a very low survival rate when lack of treatment. For further efficacy improvement of LRRC operation, recent research topics include preoperative precise evaluation, correct decision, reasonable individual treatment by multidisciplinary collaboration. Surgery remains the only option for potential cure. Studies show R0 resection is the most important prognostic factor...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28721937/-18-f-fluorodeoxyglucose-positron-emission-tomography-is-more-sensitive-than-computed-tomography-in-initial-staging-of-patients-with-an-anaplastic-t-cell-lymphoma-first-presenting-in-the-skin
#8
Caroline Ram-Wolff, Laetitia Vercellino, Pauline Brice, Roberta La Selva, Martine Bagot
BACKGROUND: The role of (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in the evaluation of anaplastic large-cell lymphoma (ALCL) first presenting in the skin is not well established, while computed tomography (CT) is used as a standard procedure. OBJECTIVES: The aim of this study was to evaluate the use of FDG-PET versus CT at initial staging of ALCL first presenting in the skin. MATERIALS & METHODS: Eleven cases of ALCL first presenting in the skin who underwent both FDG-PET and CT were retrospectively analysed...
July 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28721605/how-to-provide-gadolinium-free-pet-mr-cancer-staging-of-children-and-young-adults-in-less-than-1%C3%A2-h-the-stanford-approach
#9
Anne M Muehe, Ashok J Theruvath, Lillian Lai, Maryam Aghighi, Andrew Quon, Samantha J Holdsworth, Jia Wang, Sandra Luna-Fineman, Neyssa Marina, Ranjana Advani, Jarrett Rosenberg, Heike E Daldrup-Link
PURPOSE: To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [(18)F]FDG (2-3 MBq/kg)...
July 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28721530/-imaging-representation-of-the-aorta
#10
REVIEW
C Reeps, S Schellong, R T Hoffmann
Depending on the type and acuteness, diseases of the aorta can be imaged by a variety of techniques. Modalities and quality of imaging have developed rapidly in recent years. In combination with the clinical assessment of patients, the results obtained by imaging determine the further management. They not only establish the underlying diagnosis but provide the information essential for indications, planning and reassessment of therapy, as well as for evaluation of the clinical course and surveillance. Whereas conventional catheter-guided angiography and intravascular ultrasound are only used in exceptional cases and then in conjunction with interventional therapy, cross-sectional imaging modalities, such as contrast-enhanced computed tomography (CT) angiography and magnetic resonance imaging (MRI) are nowadays the mainstay of diagnostics...
July 18, 2017: Der Internist
https://www.readbyqxmd.com/read/28721305/fully-automated-gmp-production-of-68-ga-ga-do3a-vs-cys-40-exendin-4-for-clinical-use
#11
Irina Velikyan, Ulrika Rosenstrom, Olof Eriksson
[(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4/PET-CT targeting glucagon like peptide-1 receptor (GLP-1R) has previously demonstrated its potential clinical value for the detection of insulinomas. The production and accessibility of this radiopharmaceutical is one of the critical factors in realization of clinical trials and routine clinical examinations. Previously, the radiopharmaceutical was prepared manually, however larger scale of clinical trials and healthcare requires automation of the production process in order to limit the operator radiation dose as well as improve tracer manufacturing robustness and on-line documentation for enhanced good manufacturing practice (GMP) compliance...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721304/imaging-features-of-paget-s-disease-on-11-c-choline-pet-ct
#12
Cameron E Leitch, Ajit H Goenka, Benjamin M Howe, Stephen M Broski
The purpose of this study was to investigate the appearance of Paget's disease (PD) on (11)C choline PET/CT and correlate these findings to serum alkaline phosphatase (ALP) level and skeletal scintigraphy. With IRB approval, our institutional (11)C choline PET/CT database (9/2005-6/2015) was searched for patients with PD. Site of osseous involvement, CT appearance, and multiple semi-quantitative measures were measured and correlated with ALP and degree of uptake on bone scan. Our search identified 10 males (mean age 79...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721303/value-of-99m-tc-mdp-spect-ct-and-18-f-fdg-pet-ct-scanning-in-the-evaluation-of-malignantly-transformed-fibrous-dysplasia
#13
Wei-Jun Wei, Zhen-Kui Sun, Chen-Tian Shen, Xin-Yun Zhang, Juan Tang, Hong-Jun Song, Zhong-Ling Qiu, Quan-Yong Luo
Although fibrous dysplasia is not considered a potentially premalignant disorder, malignant transformation occurs. Because of its rarity, radiographic features of malignantly transformed fibrous dysplasia on cross-sectional imaging modalities are less recognized, making diagnosis and differential diagnosis of the disease quite difficult in clinical practice. In this study, we analyzed the clinical characteristics, imaging features, pathology findings and surgery strategies of 19 malignantly transformed fibrous dysplasia...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28720271/it-s-a-question-of-endurance-patients-with-head-and-neck-cancer-experiences-of-18-f-fdg-pet-ct-in-a-fixation-mask
#14
Camilla Andersson, Marta Röing, Ylva Tiblom Ehrsson, Birgitta Johansson
PURPOSE: This study aimed to explore how patients with head and neck cancer experienced undergoing an (18)F-fluoro-deoxy-glucose positrons emissions tomography/computed tomography ((18)F-FDG PET/CT) examination in a fixation mask. METHOD: Interviews were conducted with nine patients with known or suspected head and neck cancer who were scheduled for the examination for the first time. The phenomenological method according to van Manen and his four lifeworld existentials; lived space, lived body, lived time, and lived relation was used to analyse the interviews...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28719629/multiparametric-11c-acetate-positron-emission-tomography-magnetic-resonance-imaging-in-the-assessment-and-staging-of-prostate-cancer
#15
Stephan H Polanec, Piotr Andrzejewski, Pascal A T Baltzer, Thomas H Helbich, Alexander Stiglbauer, Dietmar Georg, Georgios Karanikas, Martin Susani, Wolfgang Wadsak, Markus Margreiter, Markus Mitterhauser, Peter Brader, Katja Pinker
BACKGROUND: The aim of this study was to evaluate whether MP [11C]Acetate PET-MRI enables an accurate differentiation of benign and malignant prostate tumors as well as local and distant staging. MATERIALS AND METHODS: Fifty-six consecutive patients fulfilling the following criteria were included in this IRB-approved prospective study: elevated PSA levels or suspicious findings at digital rectal examination or TRUS; and histopathological verification. All patients underwent MP [11C]Acetate PET-MRI of the prostate performed on separate scanners with PET/CT using [11C]Acetate and 3T MP MR imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28719451/pancreatic-ductal-adenocarcinoma-with-high-radiotracer-uptake-in-68ga-prostate-specific-membrane-antigen-pet-ct
#16
Samine Sahbai, Petra Rieping, Christina Pfannenberg, Christian la Fougère, Matthias Reimold
Prostate-specific membrane antigen imaging with PET/CT is increasingly used in prostate cancer and was shown to have a high diagnostic performance. We report a clinical case of a 67-year-old man with previous history of operated prostate cancer and increasing prostate-specific antigen blood level. Ga-HBED-CC prostate-specific membrane antigen PET/CT imaging was indicated for the assessment of local recurrence and lymph node metastases of prostate cancer. In addition, a soft tissue mass in the body of the pancreas with high radiotracer uptake was detected...
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28719450/combination-of-177lu-psma-617-and-external-radiotherapy-for-the-treatment-of-cerebral-metastases-in-patients-with-castration-resistant-metastatic-prostate-cancer
#17
Xiao Wei, Carl Schlenkhoff, Bettina Schwarz, Markus Essler, Hojjat Ahmadzadehfar
Two castration-resistant prostate cancer patients, both with cerebral and visceral and lymphatic metastases, received multiple cycles of Lu-PSMA-617 treatments. The prognosis of both cases is dependent on brain metastases. Between Lu-PSMA-617 treatment cycles, local radiotherapy was also applied to the brain metastases. Prior to the combined therapy, all systemic metastases, including cerebral lesions, showed PSMA expression using Ga-PSMA PET/CT. Under the combined therapy, all the metastases, particularly the cerebral lesions, showed significant regression in size and PSMA expression over time...
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28719449/68ga-dotatate-uptake-in-solitary-pancreatic-metastasis-from-clear-cell-renal-cancer
#18
Shankar Vamadevan, Ken Le, Lily Shen, Han Loh, Robert Mansberg
A 64-year-old man with a lesion of the pancreatic tail was referred for Ga-DOTATATE PET/CT imaging. His medical history included previous metastatic clear cell renal cell cancer. Ga-DOTATATE PET/CT demonstrated increased DOTATATE uptake (SUVmax 10.5) in a pancreatic tail lesion. Histopathology of the resected lesion confirmed clear renal cell cancer metastasis. This case illustrates that clear cell renal cancer metastasis can demonstrate Ga-DOTATATE accumulation.
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28719448/biopsy-proven-diffuse-mediastinal-prostate-cancer-metastases-negative-on-18f-fluorocholine-diagnosed-on-68ga-psma-and-18f-psma-pet-ct
#19
Guillaume Chaussé, Tamim Niazi, Gad Solomon Abikhzer, Stephan Michael Probst
A 72-year-old man with prostate cancer (stage T3b, Gleason score 7) treated by radical prostatectomy was found to have biochemical failure (prostate-specific antigen 8.5 ng/mL) and a suspicious growing nodularity at the left prostate bed on MRI. F-fluorocholine PET/CT failed to demonstrate any site of uptake suggestive of malignancy. A bone scan did exclude bone metastases. Ga-PSMA PET/CT revealed various positive lymph nodes in the supraclavicular, mediastinal, and hilar regions. This was confirmed on F-DCFPyl PET/CT, with the addition of a suspicious right axillary lymph node...
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28719447/diffuse-increased-sodium-fluoride-gastric-activity-in-a-patient-with-hypercalcemia
#20
Fuqiang Shao, Shumao Zhang, Chi Qi, Yu Wang, Yue Chen
Increased extraosseous uptake of sodium fluoride can be visualized because of many different etiologies. A 62-year-old man with a history of osteoporosis had an F-sodium fluoride PET/CT scan for accessing chest pain caused by an accident. The images showed multiple fractures. Unexpectedly, diffuse activity was noted in the gastric wall, which was suggestive of possible hypercalcemia. The serum calcium level confirmed the patient had hypercalcemia.
July 17, 2017: Clinical Nuclear Medicine
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