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https://www.readbyqxmd.com/read/29731715/anti-inflammatory-effects-of-curcumin-in-microglial-cells
#1
Yangyang Yu, Qian Shen, Yihong Lai, Sun Y Park, Xingmei Ou, Dongxu Lin, Meiling Jin, Weizhen Zhang
Lipoteichoic acid (LTA) induces neuroinflammatory molecules, contributing to the pathogenesis of neurodegenerative diseases. Therefore, suppression of neuroinflammatory molecules could be developed as a therapeutic method. Although previous data supports an immune-modulating effect of curcumin, the underlying signaling pathways are largely unidentified. Here, we investigated curcumin's anti-neuroinflammatory properties in LTA-stimulated BV-2 microglial cells. Inflammatory cytokine tumor necrosis factor-α [TNF-α, prostaglandin E2 (PGE2), and Nitric Oxide (NO] secretion in LTA-induced microglial cells were inhibited by curcumin...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29629345/comparative-effects-of-curcumin-and-tetrahydrocurcumin-on-dextran-sulfate-sodium-induced-colitis-and-inflammatory-signaling-in-mice
#2
Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh
Background: Curcumin, a yellow ingredient of turmeric ( Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29576695/demethoxycurcumin-a-natural-derivative-of-curcumin-abrogates-rotenone-induced-dopamine-depletion-and-motor-deficits-by-its-antioxidative-and-anti-inflammatory-properties-in-parkinsonian-rats
#3
Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu Chidambaram, Giles J Guillemin
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder (NDD) associated with the loss of dopaminergic neurons in the substantia nigra and subsequently has an effect on motor function and coordination. The pathology of PD is multifactorial, in which neuroinflammation and oxidative damage are the two of the main protagonists. Objectives: The present study aims to assess the potential antioxidant and anti-inflammatory effects of demethoxycurcumin (DMC), a natural derivative of curcumin, against rotenone-induced PD in rats...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29575794/morphological-and-biochemical-features-of-cerebellar-cortex-after-exposure-to-zinc-oxide-nanoparticles-possible-protective-role-of-curcumin
#4
Mona G Amer, Rehab A Karam
Zinc oxide nanoparticles (ZnONPs) are widely used in the last decades. So, Investigation of its neurotoxic effect is important. This work aimed to investigate the potential adverse effects of ZnONPs on rat's cerebellar cortex and the possible neuroprotective role of curcumin. Forty male albino rats were randomly divided into control and experimental groups. Twenty rats were injected with ZnONPs and ten of them previously received curcumin before ZnONPs then continued together for 28 days. At the end of the experiment, cerebellar tissue samples were prepared for histological, morphometric, immunohistochemical study and tissue levels of oxidative stress markers and cytokine analysis...
March 25, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29454324/investigation-of-the-anti-cataractogenic-mechanisms-of-curcumin-through-in-vivo-and-in-vitro-studies
#5
Jing Cao, Tao Wang, Meng Wang
BACKGROUND: Cataract is the leading cause of blindness in elderly people worldwide, especially in developing countries. Studies to identify strategies that can prevent or retard cataract formation are urgently required. This study aimed to investigate the potential mechanism of the cytoprotective effects of curcumin in in vivo and in vitro experiments. METHODS: Male Wistar rats were randomly divided into three groups: the control group, the model group (administered 20 μmol/kg sodium selenite), and the curcumin group (pretreated with 75 mg/kg body weight curcumin 24 h prior to the administration of sodium selenite)...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29302997/chemoprotective-effects-of-curcumin-on-doxorubicin-induced-nephrotoxicity-in-wistar-rats-by-modulating-inflammatory-cytokines-apoptosis-oxidative-stress-and-oxidative-dna-damage
#6
Fulya Benzer, Fatih Mehmet Kandemir, Sefa Kucukler, Selim Comaklı, Cuneyt Caglayan
Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However, nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate protective effects of curcumin (CMN) against DXR-induced nephrotoxicity. Rats were subjected to oral treatment of CMN (100 and 200 mg/kg body weight) for 7 days. Nephrotoxicity was induced by single intra peritoneal injection of DXR (40 mg/kg body weight) on the fifth day and then the experiment was terminated on the eighth day. Nephroprotective effects of CMN were associated with decrease in serum toxicity markers and increase in antioxidant enzyme activities...
January 5, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29246079/curcumin-pyrazole-blocks-lipopolysaccharide-induced-inflammation-via-suppression-of-jnk-activation-in-raw-264-7-macrophages
#7
Nathnarin Somchit, Rungruedee Kimseng, Rana Dhar, Poonsit Hiransai, Chatchawan Changtam, Apichart Suksamrarn, Wilanee Chunglok, Warangkana Chunglok
BACKGROUND: Targeting inflammatory macrophages and their products is an effective method for controlling inflammation. The pyrazole analog of curcumin (curcumin pyrazole, PYR) has been reported to possess superior anti-inflammatory activity to curcumin (CUR). However, the role of PYR anti-inflammatory activity in macrophages has not yet been elucidated. OBJECTIVE: To examine the anti-inflammatory effects of PYR and CUR in lipopolysaccharide (LPS)-activated RAW 264...
December 16, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29234949/curc-mpeg454-a-pegylated-curcumin-derivative-improves-anti-inflammatory-and-antioxidant-activities-a-comparative-study
#8
Fei Cheng, Yuhe Chen, Zhu Zhan, Yu Liu, Peng Hu, Hong Ren, Huadong Tang, Mingli Peng
We previously demonstrated that a PEGylated curcumin (Curc-mPEG454) significantly inhibited cyclooxygenase 2 (COX-2) expression and improved the progression of liver fibrosis. The current study systematically evaluates its anti-inflammatory and antioxidant activities in vitro in a comparative study with curcumin, aspirin, NS-398, and vitamin C. RAW264.7 murine macrophages were pretreated with Curc-mPEG454, curcumin, aspirin, NS-398, or vitamin C at the indicated concentration for 2 h; then, the cells were stimulated with 1 μg/mL lipopolysaccharide (LPS) for 24 h...
December 13, 2017: Inflammation
https://www.readbyqxmd.com/read/29225427/molecular-docking-analysis-of-curcumin-analogues-with-cox-2
#9
Mario Rowan Sohilait, Harno Dwi Pranowo, Winarto Haryadi
Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. The binding energies of -8.2, - 7.6 and -7.5 kcal/mol were obtained for three analogues of curcumin respectively. Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX-2 towards the design of potent inhibitors.
2017: Bioinformation
https://www.readbyqxmd.com/read/29180881/curcumin-potentiates-the-potent-antitumor-activity-of-acnu-against-glioblastoma-by-suppressing-the-pi3k-akt-and-nf-%C3%AE%C2%BAb-cox-2-signaling-pathways
#10
Jun Zhao, Jiabin Zhu, Xiaoshu Lv, Jinshan Xing, Shuang Liu, Chen Chen, Yinghui Xu
Glioblastoma (GBM) is a highly invasive and challenging primary tumor of the central nervous system (CNS), and currently available treatments provide limited benefits to patients with this disease. Therefore, the development of novel therapeutic targets and effective treatment strategies is essential. Nimustine hydrochloride (ACNU) is widely used as the standard chemotherapeutic agent and is frequently administered together with other chemotherapeutic agents in clinical studies. Curcumin, a natural polyphenolic compound, could potentially be combined with chemotherapeutics for cancer treatment; however, there are no reports of studies where ACNU and curcumin were combined for GBM treatment, and the mechanisms underlying their activity remain poorly understood...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29151957/curcumin-enhances-the-anticancer-effect-of-5-fluorouracil-against-gastric-cancer-through-down-regulation-of-cox-2-and-nf-%C3%AE%C2%BAb-signaling-pathways
#11
Hongru Yang, Shaoqiu Huang, Yumeng Wei, Shousong Cao, Chao Pi, Ting Feng, Jing Liang, Ling Zhao, Guosheng Ren
Background: 5-fluorouracil (5-FU) is one of the most commonly used first-line anticancer drugs to treat gastric cancer in clinical practice. However, severe adverse events such as gastrointestinal toxicity and bone marrow suppression limit its clinical application. Combination chemotherapy to combine two or more anticancer drugs with different mechanistic action is an effective anticancer strategy against gastric cancer. Therefore, we studied the anticancer effect of the combination of 5-FU with curcumin against gastric cancer MKN45 and AGS cells (normal gastric mucosal GES-1 cells as control) and associated molecular mechanisms...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28901458/neuroprotective-effects-of-curcumin-alleviate-lumbar-intervertebral-disc-degeneration-through-regulating-the-expression-of-inos-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-2-mmp%C3%A2-9-and-bdnf-in-a-rat-model
#12
Yuan Hu, Jin-Shu Tang, Shu-Xun Hou, Xiu-Xiu Shi, Jiang Qin, Tie-Song Zhang, Xiao-Jing Wang
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, transforming growth factor (TGF)‑β1/2, matrix metalloproteinase (MMP)‑9 and brain‑derived neurotrophic factor (BDNF) in a rat model of LIDD...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28882947/expression-of-cyclooxygenase-2-nitric-oxide-synthase-2-and-heme-oxygenase-1-mrna-induced-by-bis-eugenol-in-raw264-7-cells-and-their-antioxidant-activity-determined-using-the-induction-period-method
#13
Yukio Murakami, Akifumi Kawata, Seiichiro Fujisawa
BACKGROUND/AIM: To clarify the mechanisms responsible for the anti-inflammatory/proinflammatory activities of eugenol-related compounds, we investigated the cytotoxicity and up-regulatory/down-refgulatory effects of the biphenols curcumin, bis-eugenol, magnolol and honokiol, and the monophenols eugenol and isoeugenol, on major regulators of cyclooxygenase-2 (Cox-2), nitric oxide synthase 2 (Nos2) and heme oxygenase-1 (HO-1) mRNA in RAW264.7 cells. MATERIALS AND METHODS: mRNA expression was investigated using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), and the theoretical parameters were calculated using the DFT/B3LYP/6-31* method...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28856444/mechanisms-of-curcumin-induced-gastroprotection-against-ethanol-induced-gastric-mucosal-lesions
#14
Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien, Tomasz Brzozowski
BACKGROUND: Curcumin, a pleiotropic substance used for centuries in traditional medicine, exhibits antioxidant, anti-inflammatory and antiproliferative efficacy against various tumours, but the role of curcumin in gastroprotection is little studied. We determined the effect of curcumin against gastric haemorrhagic lesions induced by 75% ethanol and alterations in gastric blood flow (GBF) in rats with cyclooxygenase-1 (COX-1) and COX-2 activity inhibited by indomethacin, SC-560 or rofecoxib, inhibited NO-synthase activity, capsaicin denervation and blockade of TRPV1 receptors by capsazepine...
August 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28676971/an-in-vitro-study-ascertaining-the-role-of-h2o2-and-glucose-oxidase-in-modulation-of-antioxidant-potential-and-cancer-cell-survival-mechanisms-in-glioblastoma-u-87-mg-cells
#15
Ravi P Cholia, Sanju Kumari, Saurabh Kumar, Manpreet Kaur, Manbir Kaur, Raj Kumar, Monisha Dhiman, Anil K Mantha
Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and reprogramming of the cellular antioxidant system to cope with the adverse effects. In the present study non-cytotoxic dose of oxidants, H2O2 (100 μM) and GO (10 μU/ml) was used to induce moderate oxidative stress via generating ROS in human glioblastoma cell line U-87 MG cells, which showed a marked increase in the antioxidant capacity as studied by measuring the modulation in expression levels and activities of superoxide dismutase (SOD1 and SOD2) and catalase (CAT) enzymes, and the GSH content...
July 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28546962/recent-advances-of-curcumin-in-the-prevention-and-treatment-of-renal-fibrosis
#16
REVIEW
Xuejiao Sun, Yi Liu, Cheng Li, Xiting Wang, Ruyuan Zhu, Chenyue Liu, Haixia Liu, Lili Wang, Rufeng Ma, Min Fu, Dongwei Zhang, Yu Li
Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health. Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28513174/structure-activity-relationship-of-curcumin-role-of-the-methoxy-group-in-anti-inflammatory-and-anticolitis-effects-of-curcumin
#17
Haixia Yang, Zheyuan Du, Weicang Wang, Mingyue Song, Katherine Sanidad, Elvira Sukamtoh, Jennifer Zheng, Li Tian, Hang Xiao, Zhenhua Liu, Guodong Zhang
Curcumin, a dietary compound from turmeric, has beneficial effects on inflammatory diseases such as inflammatory bowel disease. Most previous studies have focused on the structure-activity relationship of the thiol-reactive α,β-unsaturated carbonyl groups of curcumin, so little is known about the roles of methoxy groups in biological activities of curcumin. Here we synthesized a series of curcumin analogues with different substitution groups (R = H-, Br-, Cl-, F-, NO2-, CH3-, and OH-) to replace the methoxy group and evaluated their biological effects in vitro and in vivo...
June 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28485773/curcumin-alleviates-lumbar-radiculopathy-by-reducing-neuroinflammation-oxidative-stress-and-nociceptive-factors
#18
L Xiao, M Ding, A Fernandez, P Zhao, L Jin, X Li
Current non-surgical treatments for lumbar radiculopathy [e.g. epidural steroids and Tumour necrosis factor-α (TNF-α) antagonists] are neither effective nor safe. As a non-toxic natural product, curcumin possesses an exceptional anti-inflammatory profile. We hypothesised that curcumin alleviates lumbar radiculopathy by attenuating neuroinflammation, oxidative stress and nociceptive factors. In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-α-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2...
May 9, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28284806/diarylpentadienone-derivatives-curcumin-analogues-synthesis-and-anti-inflammatory-activity
#19
Zhi Sen Wang, Liu Zeng Chen, Hai Pin Zhou, Xin Hua Liu, Fei Hu Chen
A series of new (2E,4E)-1-(substitutedphenyl)-5-(substitutedphenyl)penta-2,4-dien-1-one derivatives were designed and synthesized. Compounds 3i, 3k were determined by X-ray. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibition against LPS-induced IL-6 and TNF-α release in cell RAW 264.7 stimulated with LPS. Compound 3i showed the highest anti-inflammatory activity on decreasing IL-6 and TNF-α. The further study showed that title compound 3i inhibited expression of proteins p-p65, iNOS, COX-2 LPS-induced...
April 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28222524/a-combination-of-resveratrol-and-curcumin-is-effective-against-aluminum-chloride-induced-neuroinflammation-in-rats
#20
Amira Zaky, Ahmad Bassiouny, Mahitab Farghaly, Bassma M El-Sabaa
BACKGROUND: Experimental studies have demonstrated that aluminum is an environmental toxin that induces neuroinflammation and the development of Alzheimer's disease. OBJECTIVE: In this report, we investigated the beneficial effect of a combination of resveratrol and curcumin to reduce aluminum-induced neuroinflammation. METHOD: We employed both an in vivo model of aluminum-induced neuroinflammation and an in vitro aluminum stimulated cultured PC-12 cells...
2017: Journal of Alzheimer's Disease: JAD
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