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Nuclear medicine

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https://www.readbyqxmd.com/read/28103873/masquelier-s-grape-seed-extract-from-basic-flavonoid-research-to-a-well-characterized-food-supplement-with-health-benefits
#1
REVIEW
Antje R Weseler, Aalt Bast
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation's research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years...
January 19, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28102961/assessing-the-use-of-4dct-ventilation-in-pre-operative-surgical-lung-cancer-evaluation
#2
Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, Brian Kavanagh
PURPOSE: A primary treatment option for lung cancer patients is surgical resection. Patients who have poor lung function prior to surgery are at increased risk of developing serious and life-threatening complications after surgical resection. Surgeons use nuclear medicine ventilation-perfusion (VQ) scans along with pulmonary function test (PFT) information to assess a patient's pre-surgical lung function. The nuclear medicine images and pre-surgery PFTs are used to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung tissue that would be lost with surgical resection...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102707/patient-dosimetry-audit-for-establishing-local-diagnostic-reference-levels-for-nuclear-medicine-ct
#3
Matthew Gardner, Ngonidzashe M Katsidzira, Erin Ross, Elizabeth A Larkin
OBJECTIVES: To establish a system for patient dosimetry audit and setting of Local Diagnostic Reference Levels (LDRLs) for Nuclear Medicine (NM) CT. METHODS: Computed Radiological Information System (CRIS) data were matched with NM paper records which provided the body region and dose mode for NMCT carried out at a large UK hospital. It was necessary to divide data in terms of the NM examination type, body region and dose mode. The mean and standard deviation Dose Length Products (DLPs) for common NMCT examinations were then calculated and compared to the proposed National DRLs (NDRLs)...
January 19, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28101595/stefano-fanti-and-egesta-lopci-editors-diagnostic-nuclear-medicine-and-radionuclide-therapy-societ%C3%A3-editrice-esculapio-bologna-2016-isbn-978-88-7488-959-4
#4
Marco Raddi, Luigi Mansi
No abstract text is available yet for this article.
January 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28099985/-prospective-evaluation-of-the-quality-of-the-results-of-thyroid-surgery-in-an-ent-department
#5
Peter Rolf Issing, Hendrik Tebben, Martin Wenger, Torsten Köhler
Although the thyroid gland is located in the neck it is not a matter of fact that it is a clinical issue for the otorhinolaryngologist in Germany. Probably due to historic reasons general surgeons usually perform operations on the thyroid. As at our department this kind of treatment is an established procedure we prospectively evaluated our thyroid cases in order to present our results.The prospective study started in the year of 2014. So far 231 patients were enrolled with an average age of 53,5 years (16-89)...
January 18, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28099977/a-step-by-step-clinical-approach-for-the-management-of-neuroendocrine-tumours
#6
A Yordanova, H Ahmadzadehfar, M Gonzalez-Carmona, C Strassburg, K Mayer, G Feldmann, I Schmidt-Wolf, R Lingohr, S Fischer, G Kristiansen, M Essler
Neuroendocrine tumours (NET) are rare neoplasms, but the incidence is permanently increasing. Most of the NETs are slow proliferating and clinically silent, and for that reason, they are often diagnosed at a stage with advanced disease. The complexity and diversity of the NET-biology require the treatment of patients in specialised centres to guarantee a qualified, multidisciplinary treatment planning. At our institution, we developed an interdisciplinary model for the assessment and treatment of NET. The aim was to adapt the guidelines to the clinical practice, exchange of current knowledge, and a tailored approach to the individual patient...
January 18, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28099265/observer-agreement-of-treatment-responses-on-planar-bone-scintigraphy-in-prostate-cancer-patients-importance-of-the-lesion-assessment-method
#7
Randi F Fonager, Helle D Zacho, Signe Albertsen, Joan Fledelius, June A Ejlersen, Mette H Christensen, Ramune Aleksyniene, José A Biurrun Manresa, Lars J Petersen
PURPOSE: The aim of this study was to assess observer agreement on the evaluation of treatment responses of bone metastases by bone scintigraphy (BS) using different scoring methods in prostate cancer patients. PATIENTS AND METHODS: Sixty-three paired BS from 55 patients were included. BS was performed before and after more than 12 weeks of anticancer treatment. A panel of experienced nuclear medicine physicians from several institutions evaluated treatment response using three different methods: (a) standard clinical assessment, (b) MD Anderson criteria, and (c) Prostate Cancer Working Group 2 (PCWG-2) criteria...
January 17, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28098867/-retracted-nuclear-import-of-prototype-foamy-virus-transactivator-bel1-is-mediated-by-kpna1-kpna6-and-kpna7
#8
Jihui Duan, Zhiqin Tang, Hong Mu, Guojun Zhang
We would like to retract the article entitled "Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7" published in International Journal of Molecular Medicine 38: 339-406, 2016. The results presented in Fig. 6 have been demonstrated to be unreproducible, and we cannot provide an explanation for this. Furthermore, we have recently identified that the cell cultures used in our experiments were partly contaminated with Mycoplasma, which could have contributed to the irreproducibility of the results...
January 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28098763/new-abietane-and-kaurane-type-diterpenoids-from-the-stems-of-tripterygium-regelii
#9
Dongsheng Fan, Shuangyan Zhou, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Ming-Rong Yang, Zhi-Hong Jiang, Li-Ping Bai
Eleven new abietane type (1‒11), and one new kaurane (12), diterpenes, together with eleven known compounds (13-23), were isolated and identified from the stems of Tripterygium regelii, which has been used as a traditional folk Chinese medicine for the treatment of rheumatoid arthritis in China. The structures of new compounds were characterized by means of the interpretation of high-resolution electrospray ionization mass spectrometry (HRESIMS), extensive nuclear magnetic resonance (NMR) spectroscopic data and comparisons of their experimental CD spectra with calculated electronic circular dichroism (ECD) spectra...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28097674/monte-carlo-simulations-of-ceiling-scatter-in-nuclear-medicine-99m-tc-131-i-and-18-f
#10
Roald S Schnerr, Anouk N de Jong, Guillaume Landry, Cécile R L P N Jeukens, Roel Wierts
PURPOSE: In the design of nuclear medicine treatment and examination rooms, an important consideration is the shielding required for ionizing radiation from the radioactive isotopes used. The shielding in the walls is normally limited to a height lower than the actual ceiling height. The direct radiation, possibly with build-up correction, can be calculated relatively easily. However, little data is available to estimate the dose contribution from ionizing radiation traveling over the wall shielding and scattering off the ceiling...
January 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28097498/clinical-applications-of-a-ct-window-blending-algorithm-radio-relative-attenuation-dependent-image-overlay
#11
Jacob C Mandell, Bharti Khurana, Les R Folio, Hyewon Hyun, Stacy E Smith, Ruth M Dunne, Katherine P Andriole
A methodology is described using Adobe Photoshop and Adobe Extendscript to process DICOM images with a Relative Attenuation-Dependent Image Overlay (RADIO) algorithm to visualize the full dynamic range of CT in one view, without requiring a change in window and level settings. The potential clinical uses for such an algorithm are described in a pictorial overview, including applications in emergency radiology, oncologic imaging, and nuclear medicine and molecular imaging.
January 17, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28092862/protective-effects-of-total-flavonoids-of-astragalus-against-adjuvant-induced-arthritis-in-rats-by-regulating-opg-rankl-nf-%C3%AE%C2%BAb-pathway
#12
Xin-Yu Liu, Lu Xu, Ying Wang, Jin-Xia Li, Yu Zhang, Chong Zhang, Sha-Sha Wang, Xue-Mei Zhang
BACKGROUND: Astragalus membranaceus Bunge is one of the oldest and most frequently used crude herbs in traditional Chinese medicine. The total flavonoids of Astragalus (TFA) are the main active components isolated from Astragalus membranaceus Bunge. Our recent study has shown its potential immunomodulatory and anti-inflammatory effects in vivo and in vitro. However, its anti-arthritic effects and mechanisms of action involved have not been elucidated. The aim of this study was to evaluate the protective effects and possible mechanisms of TFA on Freund's complete adjuvant (FCA)-induced arthritis in rats...
January 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28089381/pet-ct-underlying-physics-instrumentation-and-advances
#13
I Torres Espallardo
Since it was first introduced, the main goal of PET/CT has been to provide both PET and CT images with high clinical quality and to present them to radiologists and specialists in nuclear medicine as a fused, perfectly aligned image. The use of fused PET and CT images quickly became routine in clinical practice, showing the great potential of these hybrid scanners. Thanks to this success, manufacturers have gone beyond considering CT as a mere attenuation corrector for PET, concentrating instead on design high performance PET and CT scanners with more interesting features...
January 12, 2017: Radiología
https://www.readbyqxmd.com/read/28088445/synthesis-and-exploration-of-novel-radiolabeled-bombesin-peptides-for-targeting-receptor-positive-tumor
#14
Kakali De, Indranil Banerjee, Samarendu Sinha, Shantanu Ganguly
Increasing evidence of peptide receptor overexpression in various cancer cells, warrant the development of receptor specific radiolabeled peptides for molecular imaging and therapy in nuclear medicine. Gastrin-releasing-peptide (GRP) receptor, are overexpressed in a variety of human cancer cells. The present study report the synthesis and biological evaluation of new bombesin (BBN) analogs, HYNIC-Asp-[Phe(13)]BBN(7-13)-NH-CH2-CH2-CH3:BA1, HYNIC-Pro-[Tyr(13)Met(14)]BBN(7-14)NH2:BA2 as prospective tumor imaging agent with compare to BBN(7-14)NH2:BS as standard...
January 11, 2017: Peptides
https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#15
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28081198/molecular-analysis-of-chinese-celastrus-and-tripterygium-and-implications-in-medicinal-and-pharmacological-studies
#16
Xian-Yun Mu, Liang-Cheng Zhao, Zhi-Xiang Zhang
Celastrus and Tripterygium species, which are used in traditional Chinese medicine, have attracted much attention due to their anti-tumor promoting and neuroprotective activities, in addition to their applications in autoimmune disorders. However, systematic relationships between them and among species are unclear, and it may disturb their further medicinal utilization. In the present study, the molecular analysis of combined chloroplast and nuclear markers of all Chinese Celastrus and Tripterygium was performed, and clear inter- and intra-genus relationships were presented...
2017: PloS One
https://www.readbyqxmd.com/read/28081156/generation-of-a-stable-transgenic-swine-model-expressing-a-porcine-histone-2b-egfp-fusion-protein-for-cell-tracking-and-chromosome-dynamics-studies
#17
Renan B Sper, Sehwon Koh, Xia Zhang, Sean Simpson, Bruce Collins, Jeff Sommer, Robert M Petters, Ignacio Caballero, Jeff L Platt, Jorge A Piedrahita
Transgenic pigs have become an attractive research model in the field of translational research, regenerative medicine, and stem cell therapy due to their anatomic, genetic and physiological similarities with humans. The development of fluorescent proteins as molecular tags has allowed investigators to track cell migration and engraftment levels after transplantation. Here we describe the development of two transgenic pig models via SCNT expressing a fusion protein composed of eGFP and porcine Histone 2B (pH2B)...
2017: PloS One
https://www.readbyqxmd.com/read/28081128/radiation-exposure-from-diagnostic-imaging-in-a-cohort-of-pediatric-transplant-recipients
#18
Alexandra Seal, Michael Hawkes, Ravi Bhargava, Michelle Noga, Jutta Preiksaitis, Curtis Mabilangan, Joan Robinson
Recipients of solid organ transplants (SOT) have extensive diagnostic imaging (DI). The purpose of this study was to quantify this exposure. Children from northern Alberta with SOTs at Stollery Children's Hospital, Edmonton, Alberta January 1, 2006, to July 31, 2012, were included. Effective doses of radiation were estimated using published norms for DI performed post-transplant up to October 16, 2014. The 54 eligible children had 6215 DI studies (5628 plain films, 293 computerized tomography (CT) scans, 149 positron emission topography (PET) -CT scans, 47 nuclear medicine scans and 98 cardiac catheterizations)...
2017: PloS One
https://www.readbyqxmd.com/read/28077904/regadenoson-in-myocardial-perfusion-study-first-institutional-experiences-in-bosnia-and-herzegovina
#19
Nermina Beslic, Renata Milardovic, Amera Sadija, Sejla Ceric, Zeljka Raic
INTRODUCTION: Myocardial perfusion imaging (MPI) is widely used in the evaluation of known and suspected coronary artery disease (CAD). Imaging of heart in stress and rest enables the comparison of myocardial uptake of radiotracer in proportion to the needs and coronary flow, which is used for detection of perfusion defects. Exercise stress and pharmacologic agents are used for the stressing purpose. Novel pharmacologic stressor regadenoson is A2A selective adenosine agonist, which selectively binds to the adenosine receptors in coronary arteries causing coronary dilatation...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28074772/-nuclear-medicine-techniques-for-selective-internal-radiotherapy-of-liver-cancer
#20
Peter Frøhlich Staanum, Anne Kirstine Arveschoug, Stine Maria Jentoft Kramer, Jens Erik Nielsen, Dennis Tønner Nielsen, Peter Ott, Henning Grønbæk, Gerda Elisabeth Villadsen
Selective internal radiation therapy (SIRT) of hepatocellular carcinoma has been introduced at Aarhus University Hospital. 90Y-microspheres are implanted in the tumour by catheterization of the tumour feeding liver artery. Pretreatment angiography and test treatment using 99mTc-labelled particles followed by scintigraphy ensure a feasible and effective treatment. Post-treatment imaging of radiation from 90Y visualize the localization of microspheres. Currently, SIRT is also applied for liver metastases of neuroendocrine tumours...
January 2, 2017: Ugeskrift for Laeger
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