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JOURNAL ARTICLE
Ty D Naquin, Aidan J Canning, Yuyang Gu, Jianing Chen, Chloe M Naquin, Jianping Xia, Brandon Lu, Shujie Yang, Aleksandra Koroza, Katherine Lin, Hsin-Neng Wang, William R Jeck, Luke P Lee, Tuan Vo-Dinh, Tony Jun Huang
Efficient isolation and analysis of exosomal biomarkers hold transformative potential in biomedical applications. However, current methods are prone to contamination and require costly consumables, expensive equipment, and skilled personnel. Here, we introduce an innovative spaceship-like disc that allows Acoustic Separation and Concentration of Exosomes and Nucleotide Detection: ASCENDx. We created ASCENDx to use acoustically driven disc rotation on a spinning droplet to generate swift separation and concentration of exosomes from patient plasma samples...
March 8, 2024: Science Advances
#22
JOURNAL ARTICLE
Ya-Ni Chen, Xin-Rui Fu, Hua Guo, Xin-Yao Fu, Ke-Song Shi, Tian Gao, Hai-Quan Yu
Increasing evidence indicates that long noncoding RNAs (lncRNAs) are therapeutic targets and key regulators of tumors development and progression, including melanoma. Long intergenic non-protein-coding RNA 511 (LINC00511) has been demonstrated as an oncogenic molecule in breast, stomach, colorectal, and lung cancers. However, the precise role and functional mechanisms of LINC00511 in melanoma remain unknown. This study confirmed that LINC00511 was highly expressed in melanoma cells (A375 and SK-Mel-28 cells) and tissues, knockdown of LINC00511 could inhibit melanoma cell migration and invasion, as well as the growth of subcutaneous tumor xenografts in vivo...
2024: American Journal of Cancer Research
#23
JOURNAL ARTICLE
Xusan Xu, Dan Zhong, Xiaoxia Wang, Fei Luo, Xiaomei Zheng, Taoshan Feng, Riling Chen, Yisen Cheng, Yajun Wang, Guoda Ma
There is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory factor and is related to tumor drug resistance. However, there have been no studies investigating the prognostic value and molecular function of ANKRD1 in pan-cancer. In this study, we utilized the TCGA, GTEx, GSCALite, ENCORI, CTRP, DAVID, AmiGO 2, and KEGG databases as well as R language, to explore and visualize the role of ANKRD1 in tumors. We employed the ROC curve to explore its diagnostic significance, while the Kaplan-Meier survival curve and Cox regression analysis were used to investigate its prognostic value...
March 4, 2024: Scientific Reports
#24
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S238348.].
2024: OncoTargets and Therapy
#25
JOURNAL ARTICLE
Aijun He, Fangxin Liao, Xiaohui Lin
Circular RNAs (circRNAs) exert critical functions in colorectal cancer development. In this work, we wanted to elucidate the functional role and regulatory mechanism of circ_0007351 in colorectal cancer. For quantification of circ_0007351, microRNA (miR)-5195-3p and G Protein-coupled receptor class C group 5 member A (GPRC5A), a qRT-PCR, immunoblotting or immunohistochemistry assay was performed. Effects of circ_0007351/miR-5195-3p/GPRC5A cascade were evaluated by determining cell viability, proliferation, colony formation, motility, and invasion...
February 22, 2024: Molecular Biotechnology
#26
JOURNAL ARTICLE
Ehsan Lotfi, Azam Kholghi, Fereshteh Golab, Ali Mohammadi, Mahmood Barati
BACKGROUND: Colorectal cancer (CRC), the third most prevalent and lethal disease, accounted for approximately 1.9 million new cases and claimed nearly 861,000 lives in 2018. It is imperative to develop a minimally invasive diagnostic technique for early identification of CRC. This would facilitate the selection of patient populations most suitable for clinical trials, monitoring disease progression, assessing treatment effectiveness, and enhancing overall patient care. Utilizing blood as a biomarker source is advantageous due to its minimal discomfort for patients, enabling better integration into clinical and follow-up trials...
February 7, 2024: Pathology, Research and Practice
#27
JOURNAL ARTICLE
Somaieh Hedayat, Luciano Cascione, David Cunningham, Marta Schirripa, Andrea Lampis, Jens C Hahne, Nina Tunariu, Sung Pil Hong, Silvia Marchetti, Khurum Khan, Elisa Fontana, Valentina Angerilli, Mia Delrieux, Daniel Nava Rodrigues, Letizia Procaccio, Sheela Rao, David Watkins, Naureen Starling, Ian Chau, Chiara Braconi, Nicos Fotiadis, Ruwaida Begum, Naomi Guppy, Louise Howell, Melanie Valenti, Scott Cribbes, Bernadett Kolozsvari, Vladimir Kirkin, Sara Lonardi, Michele Ghidini, Rodolfo Passalacqua, Raghad Elghadi, Luca Magnani, David J Pinato, Federica Di Maggio, Filippo Ghelardi, Elisa Sottotetti, Guglielmo Vetere, Paolo Ciraci, Georgios Vlachogiannis, Filippo Pietrantonio, Chiara Cremolini, Alessio Cortellini, Fotios Loupakis, Matteo Fassan, Nicola Valeri
BACKGROUND: The multi-kinase inhibitor regorafenib has demonstrated efficacy in chemo-refractory metastatic colorectal cancer (mCRC) patients. However, lack of predictive biomarkers and concerns over significant toxicities hamper the use of regorafenib in clinical practice. METHODS: Serial liquid biopsies were obtained at baseline and monthly until disease progression in chemo-refractory mCRC patients treated with regorafenib in a phase II clinical trial (PROSPECT-R n=40; NCT03010722) and in a multicentric validation cohort (n=241)...
February 20, 2024: Clinical Cancer Research
#28
JOURNAL ARTICLE
Lei Bi, Yuntao Zhou, Yong Zhang, Xin Zhang
Left-sided colorectal cancer (LSCC) and right-sided colorectal cancer (RSCC) belong to colorectal cancer happening at different positions, which exhibit different pathogenesis. MicroRNA (miRNA)s are widely known regulators in diverse carcinomas. This research aims to identify a differentially expressed miRNA that simultaneously regulates genes associated with LSCC and RSCC and reveal their regulatory relation in cell migration and invasion. Bioinformatics analyses were conducted to uncover the dysregulated functional genes in LSCC/RSCC and obtain their common targeted miRNAs...
January 31, 2024: Cellular and Molecular Biology
#29
JOURNAL ARTICLE
Rina Das, Dinesh Kumar Mehta, Nidhi Gupta
MicroRNA as potential biomarker for early diagnosis, differentiating various stages, interpreting the success of postoperative curative surgery and predicting early relapse of Colorectal cancer.In the realm of medical research, the quest to find effective biomarkers for various diseases has always been a top priority. Colorectal cancer (CRC), one of the leading causes of cancer-related deaths worldwide, is no exception. The emergence of microRNA (mRNA) as a potential biomarker for CRC has sparked immense interest among scientists and clinicians alike...
February 13, 2024: Drug Research
#30
JOURNAL ARTICLE
Haiguan Lin, Shidong Hu, Yuxuan Li, Songyan Li, Da Teng, Yan Yang, Boyan Liu, Xiaohui Du
OBJECTIVE: Long non-coding RNAs (lncRNAs) are of great importance in the process of colorectal cancer (CRC) tumorigenesis and progression. However, the functions and underlying molecular mechanisms of the majority of lncRNAs in CRC still lack clarity. METHODS: A Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect lncRNA NUTM2A-AS1 expression in CRC cell lines. Cell counting kit 8 (CCK-8) assay and flow cytometry were used to examine the biological functions of lncRNA NUTM2A-AS1 in the proliferation and apoptosis of CRC cells...
February 9, 2024: Current Cancer Drug Targets
#31
REVIEW
Yuan Li, Silei Sui, Ajay Goel
Gastrointestinal (GI) cancers, including colorectal, gastric, esophageal, pancreatic, and liver, are associated with high mortality and morbidity rates worldwide. One of the underlying reasons for the poor survival outcomes in patients with these malignancies is late disease detection, typically when the tumor has already advanced and potentially spread to distant organs. Increasing evidence indicates that earlier detection of these cancers is associated with improved survival outcomes and, in some cases, allows curative treatments...
February 9, 2024: Seminars in Cancer Biology
#32
REVIEW
Jun Mao, Ying Lu
Endogenous noncoding RNAs with a covalently closed loop are known as circular RNAs (circRNAs). Recently, published works have revealed that circRNAs, which act as microRNA sponges, are critical for the biological behavior of several kinds of malignancies, including tumor cell proliferation, apoptosis, invasion, and metastasis. Additionally, there is a significant correlation between circRNAs and tumor resistance, stage, prognosis, and size. At present, colorectal cancer (CRC) is one of the most serious malignant tumors for human health...
February 9, 2024: Cancer Gene Therapy
#33
REVIEW
Shelesh Krishna Saraswat, Bashar Shaker Mahmood, Freddy Ajila, Doaa Saadi Kareem, Mariem Alwan, Zainab H Athab, Jalal Brism Shaier, Seyed Reza Hosseinifard
The in-depth exploration of long non-coding RNAs (lncRNAs) reveals their pivotal and diverse roles in various disorders, particularly cancer. Within this intricate landscape, thymopoietin-antisense RNA-1 (TMPO-AS1) emerges as a noteworthy instigator of oncogenesis in humans. This exhaustive review seeks to intricately unravel the present understanding of TMPO-AS1, emphasizing its molecular foundations and highlighting its clinical applications in the realm of cancer research. TMPO-AS1 consistently exhibits heightened expression across a spectrum of cancer types, encompassing lung, colorectal, breast, cervical, bladder, pancreatic, hepatocellular, gastric, ovarian, and osteosarcoma...
February 2, 2024: Pathology, Research and Practice
#34
JOURNAL ARTICLE
S Maliborska, V Holotiuk, Y Partykevych, O Rossylna
BACKGROUND: The discovery of new markers for colorectal cancer (CRC) is of paramount importance for improving the diagnosis, prognosis, and treatment of this disease. CRC is the third most common cancer worldwide and the second leading cause of cancer-related deaths. Early detection and treatment are crucial for improving patient outcomes, but current screening methods are not foolproof. Additionally, there is a need for better prognostic markers to identify patients at high risk of recurrence or metastasis, who may benefit from more aggressive treatment...
February 3, 2024: Experimental Oncology
#35
REVIEW
Mohamed J Saadh, Omer Qutaiba B Allela, Zahraa Jasim Sattay, Rafil Adnan Hussein Al Zuhairi, Hijaz Ahmad, Gaber E Eldesoky, Mohaned Adil, Mohammed Shnain Ali
Colorectal cancer (CRC) remains a major global health concern, necessitating an in-depth exploration of the intricate molecular mechanisms underlying its progression and potential therapeutic interventions. Transforming Growth Factor-β (TGF-β) signaling, a pivotal pathway implicated in CRC plays a dual role as a tumor suppressor in the early stages and a promoter of tumor progression in later stages. Recent research has shed light on the critical involvement of noncoding RNAs (ncRNAs) in modulating the TGF-β signaling pathway, introducing a new layer of complexity to our understanding of CRC pathogenesis...
January 22, 2024: Pathology, Research and Practice
#36
JOURNAL ARTICLE
Jianfeng Ren, Bing Han, Ping Feng, Gang Shao, Yunli Chang
This study is aimed at investigating the roles of Toll-like receptor 4 (TLR4) and microRNA-7 (miR-7) in colorectal cancer (CRC) development and progression. We assessed TLR4 and miR-7 expression in CRC cells and tissues using reverse transcription-quantitative polymerase chain reaction. The relationship between miR-7 and TLR4 was analyzed through dual luciferase reporter assays. MTT, wound healing, and cell invasion assays were conducted to examine the effects of TLR4 and miR-7 on CRC cell proliferation, migration, and invasion...
February 5, 2024: Functional & Integrative Genomics
#37
JOURNAL ARTICLE
Role of MicroRNA in Hypoxic Tumours and their Potential as Biomarkers for Early Detection of Cancer.
Jayashree Pawar, Kalpita Mulye, Judith Talker, Sonu Singh Ahirwar, Ashwin Kotnis
Hypoxia is a pathophysiological condition characterized by oxygen deficiency in tissues, which negatively affects normal biological functions. It is a typical microenvironment character of almost all solid tumours. Noncoding RNA are small functional RNA molecules that regulate gene expression at chromatin and posttranscriptional levels. Micro-RNAs (miRNAs) are a type of noncoding RNA and are ~12-22 nucleotides long that are crucial in regulating gene expression by partnering with the mRNAs of protein-coding genes...
January 5, 2024: Current Molecular Medicine
#38
REVIEW
Aida Alizamir, Mohammad Amin Amini, Ashkan Karbasi, Mehdi Beyrami
There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C...
January 2024: Chonnam Medical Journal
#39
JOURNAL ARTICLE
Bayan Mehrjoei, Lida Haghnazari, Homayoon Bashiri, Nayebali Rezvani
BACKGROUND: Colorectal cancer (CRC) is a common malignancy worldwide. MicroRNAs (miRNAs) are important epigenetic alterations that notably impact various physiological and pathological processes by acting as negative regulators of gene expression. Furthermore, they have a vital function in different types of cancers, including CRC. In this research, we evaluated, for the very first time, the expression levels of miR-196a-1 in the tissue and plasma of patients with CRC and also homeobox D8 (HOXD8) as the target gene...
February 1, 2024: BMC Cancer
#40
JOURNAL ARTICLE
Yuri Giovanna Vanessa Trujillo-Fernández, Carmen Yzabal-Barbedillo, Anilú Margarita Saucedo-Sarinaña, César de Jesús Tovar-Jácome, Miriam Yadira Godínez-Rodríguez, Patricio Barros-Núñez, Martha Patricia Gallegos-Arreola, Clara Ibet Juárez-Vázquez, Tomás Daniel Pineda-Razo, María Eugenia Marín-Contreras, Mónica Alejandra Rosales-Reynoso
BACKGROUND: miRNAs are non-coding RNAs participating actively in the post-translational regulation of oncogenes, tumor suppressor, and DNA repair genes implicated in colorectal cancer (CRC). This study aims to examine the association of the variants miR-27a (rs895819 A>G), miR-196a2 (rs11614913 T>G) and miR-146a (rs2910164 C>G) in Mexican CRC patients. METHODS: DNA samples from 183 patients and 186 healthy Mexican subjects were analyzed. Variants were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology...
August 1, 2023: Archives of Iranian Medicine
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