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Colorectal cancer microRNA

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https://www.readbyqxmd.com/read/28339062/p53-microrna-374b-akt1-regulates-colorectal-cancer-cell-apoptosis-in-response-to-dna-damage
#1
Hangjun Gong, Yu Cao, Gang Han, Yun Zhang, Qing You, Yidong Wang, Yamin Pan
Colorectal cancer (CRC) has a rising morbidity worldwide and its resistance to chemotherapy has been observed in clinical treatment. Tumor suppressor p53 is well-studied in CRC, but little is known about its effects during DNA damage of CRC cells. This study was aimed at uncovering potential mechanisms of p53 regarding microRNA-374b and v-akt murine thymoma viral oncogene homolog 1 (AKT1) during DNA damage of CRC cells. CRC cells HCT116 and HT29 were transfected with p53-specific small interfering RNA (siRNA), p53 overexpression vector or miR-374b inhibitor, and then treated with 10 µM bleomycin (BLM) for 24 h to induce DNA damage...
March 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28327152/trim8-restores-p53-tumour-suppressor-function-by-blunting-n-myc-activity-in-chemo-resistant-tumours
#2
Francesca Mastropasqua, Flaviana Marzano, Alessio Valletti, Italia Aiello, Giuseppe Di Tullio, Annalisa Morgano, Sabino Liuni, Elena Ranieri, Luisa Guerrini, Giuseppe Gasparre, Elisabetta Sbisà, Graziano Pesole, Antonio Moschetta, Mariano Francesco Caratozzolo, Apollonia Tullo
BACKGROUND: TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like clear cell Renal Cell Carcinoma (ccRCC) and colorectal cancer (CRC) where it is low expressed, are still unknown. However, recent studies suggest the potential involvement of some microRNAs belonging to miR-17-92 and its paralogous clusters, which could include TRIM8 in a more complex pathway...
March 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28325280/mir-134-a-human-cancer-suppressor
#3
REVIEW
Jing-Yu Pan, Feng Zhang, Cheng-Cao Sun, Shu-Jun Li, Guang Li, Feng-Yun Gong, Tao Bo, Jing He, Rui-Xi Hua, Wei-Dong Hu, Zhan-Peng Yuan, Xin Wang, Qi-Qiang He, De-Jia Li
MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-25 nt in length, which play crucial roles through directly binding to corresponding 3' UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28322462/stat1-inhibits-mir-181a-expression-to-suppress-colorectal-cancer-cell-proliferation-through-pten-akt
#4
Xingwen Zhang, Xiang Li, Fengbo Tan, Nanhui Yu, Haiping Pei
Signal transducers and activators of transcription 1 (STAT1) exhibits tumor-suppressor properties by inhibiting oncogenic pathways and promoting tumor immunosurveillance. MicroRNAs, a group of non-coding endogenous ones, may regulate gene expression and plays specific roles in tumorigenesis. Recently, miR-181a has been reported to be associated with poor prognosis of colorectal cancer (CRC). Using human colorectal cancer cell lines, we demonstrated that STAT1 suppresses both LoVo and SW480 cell growth by down-regulating miR-181a...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28306719/chromosome-19q13-disruption-alters-expressions-of-cyp2a7-mia-and-mia-rab4b-lncrna-and-contributes-to-fap-like-phenotype-in-apc-mutation-negative-familial-colorectal-cancer-patients
#5
Lai Fun Thean, Yu Hui Wong, Michelle Lo, Carol Loi, Min Hoe Chew, Choong Leong Tang, Peh Yean Cheah
Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli (APC) gene. Our ability to exhaustively screen for APC mutations identify microsatellite-stable and APC-mutation negative familial CRC patients, enabling us to search for novel genes. We performed genome-wide scan on two affected siblings of one family and 88 ethnicity- and gender-matched healthy controls to identify deletions shared by the siblings. Combined loss of heterozygosity, copy number and allelic-specific copy number analysis uncovered 5 shared deletions...
2017: PloS One
https://www.readbyqxmd.com/read/28303484/alterations-in-microrna-expression-associated-with-alcohol-consumption-in-rectal-cancer-subjects
#6
Lila E Mullany, Jennifer S Herrick, Roger K Wolff, John R Stevens, Martha L Slattery
PURPOSE: Alcohol consumption has been purported to influence many diseases. MicroRNAs (miRNAs) may be influenced by compounds found in alcohol. In this investigation, we test the hypothesis that total alcohol, beer, wine, and hard liquor influence miRNA expression. METHODS: We studied 1447 colorectal (CR) cancer cases with normal CR mucosa and carcinoma miRNA expression data along with alcohol consumption data. We analyzed long-term and long-term and current (LTC) alcohol use for beer, liquor, and wine with miRNA expression between paired carcinoma and normal colon and rectal tissues, adjusting for multiple comparisons using the positive false discovery rate q-value...
March 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28296190/microrna-1254-inhibits-the-migration-of-colon-adenocarcinoma-cells-by-targeting-psmd10
#7
Yi-Min Chu, Hai-Xia Peng, Ying Xu, Da-Ming Yang, Feng-Li Zhou, Rong Kuai Ji Li, Yong Lin
BACKGROUND AND AIMS: MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. In the current study, we investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS: Differential miR-1254 expression was examined using real-time-PCR in CRC and control tissues. Whether miR-1254 levels correlated with colon adenocarcinoma cell proliferation and migration was determined using the CCK-8 and transwell assays. RNA sequencing was used to identify differentially expressed genes downstream of miR-1254...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28289824/a-mirna-signature-for-an-environmental-heterocyclic-amine-defined-by-a-multi-organ-carcinogenicity-bioassay-in-the-rat
#8
Ying-Shiuan Chen, Rong Wang, Wan-Mohaiza Dashwood, Christiane V Löhr, David E Williams, Emily Ho, Susanne Mertens-Talcott, Roderick H Dashwood
Heterocyclic amines (HCAs) produced during high-temperature cooking have been studied extensively in terms of their genotoxic/genetic effects, but recent work has implicated epigenetic mechanisms involving non-coding RNAs. Colon tumors induced in the rat by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) have altered microRNA (miRNA) signatures linked to dysregulated pluripotency factors, such as c-Myc and Krüppel-like factor 4 (KLF4). We tested the hypothesis that dysregulated miRNAs from PhIP-induced colon tumors would provide a "PhIP signature" for use in other target organs obtained from a 1-year carcinogenicity bioassay in the rat...
March 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28288169/the-mir-200-family-is-increased-in-dysplastic-lesions-in-ulcerative-colitis-patients
#9
Amy Lewis, Carla Felice, Tomoko Kumagai, Cecilia Lai, Kriti Singh, Rosemary R Jeffery, Roger Feakins, Eleni Giannoulatou, Alessandro Armuzzi, Noor Jawad, James O Lindsay, Andrew Silver
BACKGROUND: Colorectal cancer (CRC) is a life-threatening complication of ulcerative colitis (UC), and patients are routinely screened for the development of precancerous lesions (dysplasia). However, rates of CRC development in patients with confirmed low-grade dysplasia vary widely between studies, suggesting a large degree of heterogeneity between these lesions that is not detectable macroscopically. A better understanding of the underlying molecular changes that occur in dysplasia will help to identify lesions at higher risk of malignancy...
2017: PloS One
https://www.readbyqxmd.com/read/28280361/microrna-194-modulates-epithelial-mesenchymal-transition-in-human-colorectal-cancer-metastasis
#10
Hong-Ke Cai, Xi Chen, Yun-Hao Tang, Yong-Chuan Deng
MicroRNAs (miRNAs), as key regulators of gene expression, are closely related to tumor occurrence and progression. MiR-194 has been proved as a tumor regulatory factor in various cancers; however, the biological function and mechanism of action in colorectal cancer (CRC) have not been well explored. In the present study, we found that miR-194 expression is upregulated in CRC clinical specimens, while overexpression of miR-194 promotes cell migration and invasion in CRC cell lines. Besides, miR-194 significantly influenced the epithelial-mesenchymal transition (EMT) markers by downregulating E-cadherin expression (P<0...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28277607/identification-of-a-functional-polymorphism-affecting-microrna-binding-in-the-susceptibility-locus-1q25-3-for-colorectal-cancer
#11
Juntao Ke, Jianbo Tian, Jiaoyuan Li, Yajie Gong, Yang Yang, Ying Zhu, Yi Zhang, Rong Zhong, Jiang Chang, Jing Gong
Genome-wide association studies (GWASs) have identified dozens of susceptibility loci for colorectal cancer (CRC). However, most of them lack functional genetic variants and clear biological mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs involved in a variety of physiological and tumorigenic processes. Here we hypothesized that single nucleotide polymorphisms (SNPs) that affect miRNAs biogenesis and binding, could contribute to CRC risk in the Chinese population. To locate miRNA-related SNPs in established GWAS loci, we initially screened out five candidate SNPs using a systematic bioinformatics analysis...
March 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28266708/role-of-wnt-%C3%AE-catenin-signaling-regulatory-micrornas-in-the-pathogenesis-of-colorectal-cancer
#12
REVIEW
Farzad Rahmani, Amir Avan, Seyed Isaac Hashemy, Seyed Mahdi Hassanian
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling...
March 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28262692/mir-139-5p-as-a-novel-serum-biomarker-for-recurrence-and-metastasis-in-colorectal-cancer
#13
Jinsei Miyoshi, Shusuke Toden, Kazuhiro Yoshida, Yuji Toiyama, Steven R Alberts, Masato Kusunoki, Frank A Sinicrope, Ajay Goel
Approximately 30-50% of colorectal cancer (CRC) patients who undergo curative resection subsequently experience tumor recurrence or metastasis. Although microRNAs (miRNAs) are a class of small noncoding RNAs frequently deregulated in various human malignancies, it remains unknown if these can help predict recurrence and metastasis in CRC patients. MiRNAs were initially screened using miRNA-microarray and miRNA-seq datasets with or without recurrence. Candidate miRNAs were then tested in two independent cohorts of 111 stage II/III and 139 stage I-III CRC patients, as well as serum samples and matched primary and metastatic liver tissues...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260923/decrease-of-mir-622-expression-suppresses-migration-and-invasion-by-targeting-regulation-of-dyrk2-in-colorectal-cancer-cells
#14
Yong Wang, Jie Sun, Xilin Wei, Lan Luan, Xiandong Zeng, Cuifang Wang, Wei Zhao
BACKGROUND: More and more evidence indicates that microRNAs are present and involved in many tumor-related diseases. The function of microRNA-622 (miR-622) in colorectal cancer (CRC) remains controversial. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) has been reported as a tumor suppressor gene in different cancers. The detailed regulation mechanism of DYRK2 in CRC remains unclear. METHODS: miR-622 and DYRK2 expression levels were detected at tissue and cellular level respectively by using real time polymerase chain reaction (PCR), Western blot, and immunohistochemical staining...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28259953/identification-of-mir%C3%A2-30b-as-an-oncogene-in-renal-cell-carcinoma
#15
Lu Jin, Yifan Li, Tao He, Jia Hu, Jiaju Liu, Mingwei Chen, Min Shi, Zhimao Jiang, Shangqi Yang, Xiangming Mao, Yaoting Gui, Yongqing Lai
microRNAs (miRs) have been investigated as a novel class of regulators of cellular processes, including proliferation, apoptosis and metabolism. In particular, miR‑30b has been demonstrated to be deregulated in certain types of cancer, including lung, colorectal and gastric cancer. Previous studies of miR‑30b in renal clear cell carcinoma demonstrated that the expression level of miR‑30b was associated with distant metastasis. However, the function of miR‑30b in renal cell carcinoma (RCC) remained to be elucidated...
February 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28257633/mir-19a-promotes-colorectal-cancer-proliferation-and-migration-by-targeting-tia1
#16
Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li, Xi Chen
BACKGROUND: Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of carcinogenesis and cancer development. How TIA1 expression is regulated during CRC development remains to be carefully elucidated. METHODS: In CRC tissue sample pairs, TIA1 protein and mRNA levels were monitored by Western blot and qRT-PCR, respectively...
March 4, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28255246/mir-195-enhances-the-radiosensitivity-of-colorectal-cancer-cells-by-suppressing-carm1
#17
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He
BACKGROUND: microRNAs (miRNAs) can regulate the sensitivity of cancer cells to chemotherapy and radiotherapy. Aberrant expression of miR-195 has been found to be involved in colorectal cancer (CRC); however, its function and underlying mechanism in the radioresistance of CRC remains unclear. METHODS: The levels of miR-195 and CARM1 were detected by quantitative reverse transcription-polymerase chain reaction and Western blot analysis in HCT-116 and HT-29 cells, respectively...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28250048/micrornas-in-the-etiology-of-colorectal-cancer-pathways-and-clinical-implications
#18
REVIEW
Ashlee M Strubberg, Blair B Madison
MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and trigger mRNA degradation. Of the ∼1900 miRNA-encoding genes present in the human genome, ∼250 miRNAs are reported to have changes in abundance or altered functions in colorectal cancer. Thousands of studies have documented aberrant miRNA levels in colorectal cancer, with some miRNAs reported to actively regulate tumorigenesis. A recurrent phenomenon with miRNAs is their frequent participation in feedback loops, which probably serve to reinforce or magnify biological outcomes to manifest a particular cellular phenotype...
March 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28245474/mir-543-promotes-proliferation-and-epithelial-mesenchymal-transition-in-prostate-cancer-via-targeting-rkip
#19
Yang Du, Xiu-Heng Liu, Heng-Cheng Zhu, Lei Wang, Jin-Zhuo Ning, Cheng-Cheng Xiao
BACKGROUND/AIMS: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in the pathogenesis of prostate cancer has not been fully understood. METHODS: Expression of miR-543 and Raf Kinase Inhibitory Protein (RKIP) in clinical prostate cancer specimens, two prostate cancer cell lines, namely LNCAP and C4-2B, were determined...
February 28, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28243124/mirna-320a-inhibits-tumor-proliferation-and-invasion-by-targeting-c-myc-in-human-hepatocellular-carcinoma
#20
Fei Xie, Yuncang Yuan, Luyang Xie, Pengzhan Ran, Xudong Xiang, Qionglin Huang, Guoxiang Qi, Xiaopeng Guo, Chunjie Xiao, Shangyong Zheng
BACKGROUND: Downregulated expression levels of microRNA-320a (miR-320a) were found in primary breast cancers and colorectal cancer. Previous findings indicated that miRNA-320a may involve in the cancer development. In this study, we explored the roles of miR-320a by targeting c-Myc in the tumor growth of hepatocellular carcinoma (HCC). METHODS: Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-320a in 50 HCC tissues and four HCC cells...
2017: OncoTargets and Therapy
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