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Colorectal cancer microRNA

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https://www.readbyqxmd.com/read/28209128/mir-296-inhibits-the-metastasis-and-epithelial-mesenchymal-transition-of-colorectal-cancer-by-targeting-s100a4
#1
Zheng He, Lianhua Yu, Shiyi Luo, Mingzhen Li, Junbo Li, Qi Li, Yi Sun, Chengbin Wang
BACKGROUND: Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of colorectal cancer (CRC). miR-296 was found to play either oncogenic or tumor suppressive role in human cancers. However, the status of miR-296 and its function in CRC remain unknown. METHODS: The expression of miR-296 was confirmed by qRT-PCR in CRC tissues and cells, and its level was altered by corresponding miRNA vectors. Wound healing and Transwall assays were performed to detect the migration and invasion of CRC cells...
February 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28207045/remodelling-of-micrornas-in-colorectal-cancer-by-hypoxia-alters-metabolism-profiles-and-5-fluorouracil-resistance
#2
Anke Nijhuis, Hannah Thompson, Julie Adam, Alexandra Parker, Luke Gammon, Amy Lewis, Jacob G Bundy, Tomoyoshi Soga, Aisha Jalaly, David Propper, Rosemary Jeffery, Nirosha Suraweera, Sarah McDonald, Mohamed A Thaha, Roger Feakins, Robert Lowe, Cleo L Bishop, Andrew Silver
No abstract text is available yet for this article.
February 16, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28193514/microrna-301a-promotes-intestinal-inflammation-and-colitis-associated-cancer-development-by-inhibiting-btg1
#3
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A), compared to tissues from patients without IBD. We studied the mechanisms of MIR301A in progression of IBD in human tissues and mice. METHODS: We isolated intestinal epithelial cells (IECs) from colon biopsy samples of 153 patients with different stages of IBD activity, 6 patients with colitis-associated cancer (CAC), and 35 healthy individuals (controls), enrolled in the study in Shanghai, China...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28193082/expression-analysis-of-previously-verified-fecal-and-plasma-dow-regulated-micrornas-mir-4478-1295-3p-142-3p-and-26a-5p-in-ffpe-tissue-samples-of-crc-patients
#4
Reza Ghanbari, Sama Rezasoltani, Javad Hashemi, Ashraf Mohamadkhani, Arash Tahmasebifar, Ehsan Arefian, Naser Mobarra, Jahanbakhsh Asadi, Ehsan Nazemalhosseini Mojarad, Yaghoub Yazdani, Sakari Knuutila, Reza Malekzadeh
BACKGROUND: Colorectal cancer (CRC) is one of the most common causes of cancer-related mortality worldwide. Early diagnosis of this neoplasm is critical and may reduce patients' mortality. MicroRNAs are small non-coding RNA molecules whose expression pattern can be altered in various diseases such as CRC. METHODS: In this study, we evaluated the expression levels of miR-142-3p, miR-26a-5p (their reduced expression in plasma samples of CRC patients was previously confirmed), miR-4478 and miR-1295-3p (their reduced expression in stool samples of CRC patients was previously confirmed) in tissue samples of CRC patients in comparison to healthy subjects...
February 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28186967/microrna-146a-promote-cell-migration-and-invasion-in-human-colorectal-cancer-via-carboxypeptidase-m-src-fak-pathway
#5
Di Lu, Qunyan Yao, Cheng Zhan, Zhang Le-Meng, Hongchun Liu, Yu Cai, Chuantao Tu, Xi Li, Yanting Zou, Shuncai Zhang
Colorectal cancer (CRC) is one of the most common cancers worldwide, and microRNAs play important roles in CRC progression. This study aimed to investigate the roles of miR-146a-5p in human CRC and their molecular mechanisms. First, we found that miR-146a-5p was significantly upregulated in CRC tissues and promoted the migration of CRC cells. Then, we identified carboxypeptidase M (CPM) as a direct target of miR-146a-5p, and found that it inhibited the migration and invasion of CRC cells. Our results also showed that CPM expression was positively correlated with overall survival and negatively correlated with recurrence, lymph node invasion, and N stage...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28186962/microrna-375-inhibits-colorectal-cancer-cells-proliferation-by-downregulating-jak2-stat3-and-map3k8-erk-signaling-pathways
#6
Ran Wei, Qin Yang, Bing Han, Yan Li, Kun Yao, Xiuyu Yang, Zexi Chen, Shanshan Yang, Jiaqi Zhou, Meizhang Li, Haijing Yu, Min Yu, Qinghua Cui
MicroRNA-375 is involved in many types of alimentary system cancers. Our previous studies showed that microRNA-375 was significantly down-regulated in carcinoma tissues compared with para-carcinoma tissues, which strongly indicates that microRNA-375 might suppress the occurrence and development of colorectal cancer. However, the mechanism underlying the microRNA-375 regulation in colorectal cancer remains unclear. In this study, we first sorted out jak2, map3k8 and atg7 as microRNA-375 targeted genes from multiple databases, and found that jak2, map3k8 and their downstream genes stat3 and erk were up-regulated in carcinoma tissues...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178667/anti-gd2-ch14-18-cho-coated-nanoparticles-mediate-glioblastoma-gbm-specific-delivery-of-the-aromatase-inhibitor-letrozole-reducing-proliferation-migration-and-chemoresistance-in-patient-derived-gbm-tumor-cells
#7
Amanda Tivnan, Tatjana Heilinger, Joanne Ramsey, Gemma O'Connor, Jenny Pokorny, Jann Sarkaria, Brett Stringer, Bryan Day, Andrew Boyd, Ella Kim, Holger Lode, Sally-Ann Cryan, Jochen Prehn
Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in an aggressive brain cancer called glioblastoma (GBM) may represent a new treatment strategy. In this study, aromatase inhibition was achieved using third generation inhibitor, Letrozole, encapsulated within the core of biodegradable poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs). PLGA-NPs were conjugated to human/mouse chimeric anti-GD2 antibody ch14...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177881/a-panel-of-microrna-signature-in-serum-for-colorectal-cancer-diagnosis
#8
Mingxia Zhu, Zebo Huang, Danxia Zhu, Xin Zhou, Xia Shan, Lian-Wen Qi, Lirong Wu, Wenfang Cheng, Jun Zhu, Lan Zhang, Huo Zhang, Yan Chen, Wei Zhu, Tongshan Wang, Ping Liu
Dysregulated expression of specific microRNAs (miRNAs) in serum has been recognised as promising diagnostic biomarkers for colorectal cancer (CRC). In the initial screening phase, a total of 32 differentially expressed miRNAs were selected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel with 3 CRC pool samples and 1 normal control (NC) pool. Using qRT-PCR, selected serum miRNAs were further confirmed in training (30 CRC VS. 30 NCs) and testing stages (136 CRC VS...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28176652/mechanisms-for-inhibition-of-colon-cancer-cells-by-sulforaphane-through-epigenetic-modulation-of-microrna-21-and-human-telomerase-reverse-transcriptase-htert-down-regulation
#9
Samantha L Martin, Rishabh Kala, Trygve O Tollefsbol
Epigenetic modulations such as histone modifications are becoming increasingly valued for their ability to modify genes without altering the DNA sequence. Many bioactive compounds have been shown to alter genetic and epigenetic profiles in various forms of 6 cancers. Of the many dietary phytochemicals, sulforaphane (SFN), found in cruciferous vegetables such as kale, cabbage and broccoli sprouts, has been present as one of the most potent (histone deacetylase) HDAC inhibitors to date. Recently, it has been 9 identified that HDAC inhibitors may play a vital role in regulating microRNAs (miRNAs) in many human cancers...
February 5, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28161537/mir-598-inhibits-metastasis-in-colorectal-cancer-by-suppressing-jag1-notch2-pathway-stimulating-emt
#10
Jia Chen, Haichen Zhang, Ying Chen, Guanglei Qiao, Weihua Jiang, Peihua Ni, Xiangfan Liu, Lijun Ma
MicroRNAs (miRNAs) are a class of endogenous, evolutionarily conserved small non-coding RNA molecules that mediate the posttranscriptional process of target gene, leading to translational repression or degradation of target mRNAs. A series of studies have indicated that miRNAs play an important role in tumor initiation, development and progression. In this study, we found that down regulation of miR-598 was a frequent event in CRC tissues compared to the paracarcinoma tissues. And the study demonstrated that miR-598 was implicated in CRC metastasis...
February 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28152545/blood-based-micrornas-as-biomarkers-for-the-diagnosis-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#11
Jane V Carter, Norman J Galbraith, Dongyan Yang, James F Burton, Samuel P Walker, Susan Galandiuk
BACKGROUND: Colorectal cancer (CRC) is common and associated with significant mortality. Current screening methods for CRC lack patient compliance. microRNAs (miRNAs), identified in body fluids, are negative regulators of gene expression and are dysregulated in many cancers, including CRC. This paper summarises studies identifying blood-based miRNAs dysregulated in CRC compared with healthy controls in an attempt to evaluate their use as a screening tool for the diagnosis of CRC. METHODS: A search of electronic databases (PubMed and EMBASE) and grey literature was performed between January 2002 and April 2016...
February 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28150434/microrna-577-suppresses-tumor-growth-and-enhances-chemosensitivity-in-colorectal-cancer
#12
Haiping Jiang, Hui Ju, Lin Zhang, Haijun Lu, Kan Jie
In this work, we aimed to determine the expression and biological functions of microRNA (miR)-577 in colorectal cancer (CRC). The results showed that miR-577 was downregulated in CRC specimens and cell lines. Restoration of miR-577 significantly suppressed the proliferation and colony formation and induced a G0/G1 cell cycle arrest in CRC cells. 5-Fluorouracil (5-FU)-resistant SW480 cells (SW480/5-FU) were found to have elevated levels of miR-577. Ectopic expression of miR-577 enhanced 5-FU sensitivity in SW480/5-FU cells...
February 2, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28149533/tff3-dependent-resistance-of-human-colorectal-adenocarcinoma-cells-ht-29-b6-to-apoptosis-is-mediated-by-mir-491-5p-regulation-of-lncrna-prins
#13
Carlos Hanisch, Jutta Sharbati, Barbara Kutz-Lohroff, Otmar Huber, Ralf Einspanier, Soroush Sharbati
Tumour necrosis factor-α (TNF-α) is a double-edged cytokine associated with pathogenesis of inflammatory-related cancers being also able to induce cancer cell death. In the process of tumour development or metastasis, cancer cells can become resistant to TNF-α. In trefoil factor 3 (TFF3) overexpressing colorectal adenocarcinoma cells (HT-29/B6), we observed enhanced resistance against TNF-α/interferon gamma-induced apoptosis. TFF3 is a secreted small peptide that supports intestinal tissue repair but is also involved in intestinal tumour progression and scattering...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28147317/ezh2-expression-is-a-prognostic-biomarker-in-patients-with-colorectal-cancer-treated-with-anti-egfr-therapeutics
#14
Itaru Yamamoto, Katsuhiko Nosho, Shinichi Kanno, Hisayoshi Igarashi, Hiroyoshi Kurihara, Keisuke Ishigami, Kazuya Ishiguro, Kei Mitsuhashi, Reo Maruyama, Hideyuki Koide, Hiroyuki Okuda, Tadashi Hasegawa, Yasutaka Sukawa, Kenji Okita, Ichiro Takemasa, Hiroyuki Yamamoto, Yasuhisa Shinomura, Hiroshi Nakase
The polycomb group protein enhancer of zeste homolog 2 (EZH2) is a methyltransferase that suppresses microRNA-31 (miR-31) in various human malignancies including colorectal cancer. We recently suggested that miR-31 regulates the signaling pathway downstream of epidermal growth factor receptor (EGFR) in colorectal cancer. Therefore, we conducted this study for assessing the relationship between EZH2 expression and clinical outcomes in patients with colorectal cancer treated with anti-EGFR therapeutics. We immunohistochemically evaluated EZH2 expression and assessed miR-31 and gene mutations [KRAS (codon 61/146), NRAS (codon 12/13/61), and BRAF (codon 600)] in 109 patients with colorectal cancer harboring KRAS (codon 12/13) wild-type...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28138309/polymorphisms-in-microrna-binding-sites-predict-colorectal-cancer-survival
#15
Ying-Pi Yang, Wen-Chien Ting, Lu-Min Chen, Te-Ling Lu, Bo-Ying Bao
Background: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers. We hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer. Methods: Sixteen common SNPs within miRNA target sites were identified, and the association between these SNPs and overall survival was assessed in colorectal cancer patients using Kaplan-Meier analysis, Cox regression model, and survival tree analysis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28123705/the-diagnostic-effect-of-serum-mir-196b-as-biomarker-in-colorectal-cancer
#16
Chunjie Xu, Lei Gu
The microRNA, miR-196b, serves a role in normal cell differentiation, proliferation and tumorigenesis of different types of cancer. The aim of the present study was to explore the serum expression of miR-196b in colorectal cancer (CRC) and its correlation with clinicopathological features. Sera samples were obtained from 103 patients with CRC, 51 patients with colorectal adenoma (Ad) and 100 healthy individuals for the present study. The serum expression of miR-196b in sera samples of the three cohorts was detected using reverse transcription-quantitative polymerase chain reaction...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28123526/mir-433-reduces-cell-viability-and-promotes-cell-apoptosis-by-regulating-macc1-in-colorectal-cancer
#17
Jiaxin Li, Xuping Mao, Xing Wang, Ganggang Miao, Jiaxin Li
MicroRNAs (miRNAs) are reported to have important roles in regulating the progression of numerous human cancers, although little is known regarding the role of miRNAs in colorectal cancer. The present study aimed to investigate the role of microRNA-433 (miR-433) in colorectal cancer. The expression levels of miR-433 and its target gene metastasis associated in colon cancer-1 (MACC1) in colorectal cancer tissues were evaluated using reverse transcription-quantitative polymerase chain reaction and western blotting...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28112364/microrna-141-inhibits-tumor-growth-and-minimizes-therapy-resistance-in-colorectal-cancer
#18
Jun Ye, Zhen Wang, Jing Zhao, Wuzhen Chen, Dang Wu, Pin Wu, Jian Huang
Colorectal cancer (CRC) is one of most common cancers and causes of cancer-associated mortality worldwide, due to its recurrence, metastasis and therapy resistance. Cancer stem cells (CSC) have been demonstrated to be vital for tumor initiation and recurrence. microRNAs may act as an oncogenes or tumor suppressors in numerous cancers. The present study demonstrated that microRNA-141 (miR‑141) was downregulated in CSC compared with differentiated cancer cells, and in tumor compared with healthy tissue. miR‑141 may inhibit CRC cell proliferation and the maintenance of CSC stemness, thereby enhancing drug susceptibility...
January 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28105216/identification-of-potential-therapeutic-targets-for-colorectal-cancer-by-bioinformatics-analysis
#19
Ming Yan, Maomin Song, Rixing Bai, Shi Cheng, Wenmao Yan
The aim of the present study was to identify potential therapeutic targets for colorectal cancer (CRC). The gene expression profile GSE32323, containing 34 samples, including 17 specimens of CRC tissues and 17 of paired normal tissues from CRC patients, was downloaded from the Gene Expression Omnibus database. Following data preprocessing using the Affy and preprocessCore packages, the differentially-expressed genes (DEGs) between the two types of samples were identified with the Linear Models for Microarray Analysis package...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105166/mir-217-regulates-tumor-growth-and-apoptosis-by-targeting-the-mapk-signaling-pathway-in-colorectal-cancer
#20
Nan Zhang, Canrong Lu, Lin Chen
MicroRNA (miR)-217 has been reported to participate in carcinogenesis and tumor progression in several cancers; however, its expression and biological functions in colorectal cancer (CRC) are still unclear. The present study demonstrated that miR-217 expression was significantly higher in matched adjacent noncancerous tissues than in CRC tissues (P<0.001). In addition, it was observed that low-grade CRC exhibited greater expression of miR-217 compared with high-grade CRC (P<0.05). Kaplan-Meier survival and Cox regression analyses revealed that overall survival rates were significantly poorer in the low-expression group relative to the high-expression group (P<0...
December 2016: Oncology Letters
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