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Colorectal cancer microRNA

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https://www.readbyqxmd.com/read/28944887/microrna%C3%A2-212-inhibits-colorectal-cancer-cell-viability-and-invasion-by-directly-targeting-pik3r3
#1
Jian Zhang, Yongkang Zhang, Xiaoyun Li, Hongbo Wang, Quan Li, Xiaofeng Liao
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer‑associated mortalities worldwide. Emerging evidence has shown that abnormal microRNA (miRNA) expression contributes to CRC carcinogenesis and progression by inhibiting the expression of their target genes. Therefore, investigating the expression patterns and roles of miRNAs specifically involved in CRC formation, and progression would help expand our knowledge on CRC and provide novel therapeutic targets for CRC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944840/correlation-analysis-between-liver-metastasis-and-serum-levels-of-mir%C3%A2-200-and-mir%C3%A2-141-in-patients-with-colorectal-cancer
#2
Meng Ding, Tao Zhang, Shijie Li, Ying Zhang, Yunfeng Qiu, Bin Zhang
Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progression of colorectal cancer, and their role in liver metastasis remain to be fully elucidated. The aim of the present study was to investigate the role of miR‑200 and miR‑141 in the progression and liver metastasis of colorectal cancer in patients...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943952/mirna-biogenesis-associated-rnase-iii-nucleases-drosha-and-dicer-are-upregulated-in-colorectal-adenocarcinoma
#3
Shin Kim, Mei Ling Song, Hyeonji Min, Ilseon Hwang, Seong Kyu Baek, Taeg Kyu Kwon, Jong-Wook Park
Drosha and Dicer are important regulators of microRNA (miRNA) biogenesis, and it has been suggested that their aberrant regulation may cause colorectal cancer (CRC). The aim of the present study was to evaluate the mRNA expression levels of these two important RNase III nucleases and their association with clinical features in CRC specimens from South Korean patients. The expression levels of Drosha and Dicer mRNA were investigated in 77 CRC tissues and adjacent histologically non-neoplastic tissues using the quantitative polymerase chain reaction...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28938522/mir-539-inhibits-human-colorectal-cancer-progression-by-targeting-runx2
#4
Dacheng Wen, Songhe Li, Weidong Jiang, Jiaming Zhu, Jingjing Liu, Shutao Zhao
Emerging evidence has shown that microRNAs (miRNAs) such as miR-539 play critical roles in carcinogenesis and progression in many types of cancer, including human colorectal cancer (CRC). However, the roles and underlying mechanism of miR-539 in CRC have not been well identified. The aims of this study were, therefore, to investigate the regulatory role and potential mechanism of miR-539 in human CRC. Here, we show that miR-539 expression is downregulated in CRC tissues and cell lines. The expression level of miR-539 is inversely associated with advanced clinical stage and lymph node metastasis...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28933597/microrna-1297-inhibits-the-growth-and-metastasis-of-colorectal-cancer-by-suppressing-cyclin-d2-expression
#5
Yanan Wang, Jinfang Xue, Haoyu Kuang, Xiaojun Zhou, Liya Liao, Fang Yin
microRNAs (miR) can potentially be used for categorizing the various subtypes of colorectal cancer (CRC) and predicting a patient's response to treatment with traditional anti-CRC therapies. We investigated how miR-1297 and its potential target molecule cyclin D2 (CCND2) might affect the progression of CRC. Thirty-two pairs of CRC specimens and corresponding samples of para-tumor tissue were collected and examined for their levels of miR-1297 and CCND2 expression. We also examined miR-1297 and CCND2 expression in cultured SW480 cells...
September 21, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28932920/microrna-30a-inhibits-colorectal-cancer-metastasis-through-down-regulation-of-type-i-insulin-like-growth-factor-receptor
#6
Y C Liu, Y R Park, S L Kim, S T Lee, S W Kim
BACKGROUND: miR-30a expression is down-regulated and regulates tumor suppressors in various cancers. AIM: We investigated the mechanisms underlying the biological role of miR-30a in CRC. METHODS: MicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot. The migration and invasion abilities of CRC were determined by wound healing assay, and trans-well migration and invasion. A luciferase reporter assay was used to confirm the targets of miR-30a...
September 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28928161/the-immune-microenvironment-confers-chemoresistance-of-colorectal-cancer-through-macrophage-derived-il-6
#7
Zhaohui Huang, Yuan Yin, Surui Yao, Yaling Hu, Yuyang Feng, Min Li, Zehua Bian, Jiwei Zhang, Yan Qin, Xiaowei Qi, Le-Yuan Zhou, Bojian Fei, Jian Zou, Dong Hua
PURPOSE: Tumor-associated macrophages (TAMs) are frequently associated with poor prognosis in human cancers. However, the effects of TAM in colorectal cancer (CRC) are contradictory. We therefore investigated the functions, mechanisms and clinical significance of TAMs in CRC. EXPERIMENTAL DESIGN: We measured the macrophage infiltration (CD68), P-gp and Bcl2 expression in CRC tissues using Immunohistochemistry staining. Co-culture of TAMs and CRC cells both in vitro and in vivo models was used to evaluate the effects of TAMs on CRC chemoresistance...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28928082/mir-338-3p-confers-5-fluorouracil-resistance-in-p53-mutant-colon-cancer-cells-by-targeting-the-mammalian-target-of-rapamycin
#8
Jia Han, Jie Li, Kaijie Tang, Huahua Zhang, Bo Guo, Ni Hou, Chen Huang
Evidence demonstrate that p53 mutations and microRNAs (miRs) are important components of 5-FU resistance in colorectal cancer (CRC). miR-338-3p has been reported associated with cancer prognosis. However whether or not it influences chemotherapy sensitivity and the underlying mechanisms have not been elucidated. Here, three types of human colon cancer cell lines, HT29 (mutant p53), HCT116 (wild-type p53), and HCT116 p53(-/-) (deficient p53), were treated with 5-FU. We showed that expression of miR-338-3p was correlated with apoptosis and 5-FU resistance in colon cancer cells...
September 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28927149/microrna-552-promotes-tumor-cell-proliferation-and-migration-by-directly-targeting-dach1-via-the-wnt-%C3%AE-catenin-signaling-pathway-in-colorectal-cancer
#9
Jia Cao, Xiu-Rui Yan, Ting Liu, Xue-Bo Han, Jing-Jing Yu, Shi-Hai Liu, Li-Bin Wang
The purpose of the present study was to analyze the crucial role of microRNAs (miRNAs/miRs) involved in the proliferation and migration of colorectal cancer (CRC) and to investigate their underlying mechanisms. The present study discusses the expression and function of miR-552 in CRC. The expression level of miR-552 in CRC cells and tissues was observed, and it was suggested that the high expression of miR-552 accelerated the proliferation and migration of CRC cells in vitro. Notably, a result of the present study was that the cell fate determination factor Dachshund family transcription factor 1 (DACH1) was identified as a direct target of miR-552...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927141/catalpol-promotes-cellular-apoptosis-in-human-hct116-colorectal-cancer-cells-via-microrna-200-and-the-downregulation-of-pi3k-akt-signaling-pathway
#10
Lan Liu, Hongwei Gao, Hongbo Wang, Yuan Zhang, Weihua Xu, Sen Lin, Hongjuan Wang, Qiong Wu, Jianqiang Guo
Catalpol is an effective active ingredient that functions as a diuretic and laxative, and exhibits blood sugar-lowering, liver protective, anti-aging and anticancer effects. In traditional Chinese medicine, catalpol is believed to be Yin nourishing. The anticancer effect of catalpol on human HCT116 colorectal cancer cells were investigated and the mechanism of action was evaluated. Cellular viability was detected using an MTT assay. Caspase-3 and caspase-9 activity, cellular apoptosis and nucleic morphology were analyzed using caspase-3 and caspase-9 activity assay kits, flow cytometric assays and DAPI staining assay, respectively...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927076/microrna-154-inhibits-the-growth-and-metastasis-of-gastric-cancer-cells-by-directly-targeting-mtdh
#11
Wenhui Qiao, Nong Cao, Lei Yang
MicroRNAs (miRNAs) are a group of non-protein-coding, highly conserved single-stranded RNA molecules. The abnormal expression of miRNAs has been demonstrated to have an important function in the carcinogenesis and progression of gastric cancer. microRNA-154 (miR-154) has been reported to be downregulated in non-small cell lung, colorectal and prostate cancer. However, the expression and roles of miR-154 in gastric cancer remain to be established. The present study measured the expression levels of miR-154 in gastric cancer tissues and cell lines...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927068/microrna-184-inhibits-cell-proliferation-and-metastasis-in-human-colorectal-cancer-by-directly-targeting-igf-1r
#12
Guannan Wu, Jiayun Liu, Zhenfeng Wu, Xiaoyu Wu, Xuequan Yao
Colorectal cancer is currently the third most common cancer in males and the second in females worldwide. In spite of marked progress having been achieved in surgical resection, radiotherapy and chemotherapy, the prognosis for patients with colorectal cancer remains poor. Previous studies have demonstrated that the abnormal expression of microRNAs contributed to human cancer carcinogenesis and progression, suggesting miRNAs as novel therapeutic targets in colorectal cancer. The aim of the present study was to investigate the expression, functions and underlying molecular mechanisms of microRNA-184 (miR-184) in colorectal cancer...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28918036/therapeutic-suppression-of-mir-4261-attenuates-colorectal-cancer-by-targeting-mcc
#13
Guanming Jiao, Qi Huang, Muren Hu, Xuchun Liang, Fuchen Li, Chunling Lan, Wencheng Fu, Yu An, Bin Xu, Jinzhe Zhou, Junjie Xiao
The mutated in colorectal cancer (MCC) gene is an important colorectal tumor suppressor gene, although few studies have reported the microRNA(s) that could directly target MCC in colorectal cancer. Here, we used microRNA (miRNA) target prediction algorithms, and previously reported microarray data in human colorectal cancer found that only miR-4261 was predicted by all three databases to directly target MCC. Based on specimens from our own cohort of colorectal cancer patients, we further demonstrated that miR-4261 was overexpressed in colorectal cancer...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#14
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions s worldwide, to date, MicroRNA 1290 (miRNA) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells, its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay and soft agar growth assay. IN addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced p27 level and increased Cyclin D1 level both in mRNA and protein levels, while miR-1290 knockdown increased p27 and reduced Cyclin D1 (confirming miR-1290 promoted CRC cell proliferation)...
September 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28915552/dicer-suppresses-cytoskeleton-remodeling-and-tumorigenesis-of-colorectal-epithelium-by-mir-324-5p-mediated-suppression-of-hmgxb3-and-wasf-2
#15
Li Na Sun, Cheng Xing, Zheng Zhi, Yao Liu, Liang-Yan Chen, Tong Shen, Qun Zhou, Yu Hong Liu, Wen Juan Gan, Jing-Ru Wang, Yong Xu, Jian Ming Li
Emerging evidence indicates that microRNAs, a class of small and well-conserved noncoding RNAs, participate in many physiological and pathological processes. RNase III endonuclease DICER is one of the key enzymes for microRNA biogenesis. Here, we found that DICER was downregulated in tumor samples of colorectal cancer (CRC) patients at both mRNA and protein levels. Importantly, intestinal epithelial cell (IEC)-specific deletion of Dicer mice got more tumors after azoxymethane and dextran sulfate sodium (DSS) administration...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28905214/mir-217-5p-induces-apoptosis-by-directly-targeting-prkci-bag3-itgav-and-mapk1-in-colorectal-cancer-cells
#16
Marion Flum, Michael Kleemann, Helga Schneider, Benjamin Weis, Simon Fischer, René Handrick, Kerstin Otte
Apoptosis is a genetically directed process of programmed cell death. A variety of microRNAs (miRNAs), endogenous single-stranded non-coding RNAs of about 22 nucleotides in length have been shown to be involved in the regulation of the intrinsic or extrinsic apoptotic pathways. There is increasing evidence that the aberrant expression of miRNAs plays a causal role in the development of diseases such as cancer. This makes miRNAs promising candidate molecules as therapeutic targets or agents. MicroRNA (miR)-217-5p has been implicated in carcinogenesis of various cancer entities, including colorectal cancer...
September 14, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28902152/micrornas-as-biomarkers-in-colorectal-cancer
#17
REVIEW
Takaaki Masuda, Naoki Hayashi, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Koshi Mimori
MicroRNAs (miRs) are small RNAs that repress mRNA translation, resulting in the degradation of mRNAs and regulation of the expression levels of various genes. Recent studies have shown that aberrant miR expression has a functional role in the initiation and progression of various malignancies, including colorectal cancer (CRC), which is one of the leading causes of cancer-related death worldwide. miRs have also been shown to have applications as diagnostic, prognostic, and predictive biomarkers because of their high tissue specificity, stability, and altered expression in tumor development...
September 13, 2017: Cancers
https://www.readbyqxmd.com/read/28881790/microrna-profiles-involved-in-trifluridine-resistance
#18
Kenta Tsunekuni, Masamitsu Konno, Ayumu Asai, Jun Koseki, Takashi Kobunai, Teiji Takechi, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Trifluridine (FTD) is a key component of the novel oral antitumor drug trifluridine/tipiracil, which is approved for the treatment of patients with metastatic colorectal cancer refractory to standard chemotherapies. A microRNA analysis of three colorectal cell lines was conducted to investigate causes of FTD resistance. Drug resistant sublines of DLD-1, HCT-116, and RKO cells were developed by continuous administration of increasing doses of FTD for 5 months. The let-7d-5p gene, which maps to chromosome 9q22...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881738/expression-analysis-of-microrna-as-prognostic-biomarkers-in-colorectal-cancer
#19
Jie Yang, Dongling Ma, Andrew Fesler, Haiyan Zhai, Apisri Leamniramit, Wenzhe Li, Song Wu, Jingfang Ju
microRNA (miRNA) based biomarkers have unique advantages due to their critical regulatory function, superior stability, and relatively small number compared to mRNAs. A number of miRNAs play key roles in colon cancer stem cell chemoresistance and have clinical potential as prognostic biomarkers. The purpose of this study is to systematically validate the prognostic potential of miRNAs in colorectal cancer. In this study, we validated the prognostic potential of a panel of miRNAs using 205 stage II, III, and IV colorectal cancer specimens by qRT-PCR analysis...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881590/upregulation-of-microrna-125b-by-g-csf-promotes-metastasis-in-colorectal-cancer
#20
Xinghua Zhang, Xiao Ma, Huaying An, Changqing Xu, Wenjo Cao, Wei Yuan, Jie Ma
Although there are reports of miR-125b being dysregulated in colorectal cancer (CRC) and associated with CRC progression, little is known about its intrinsic regulatory mechanisms. Here we detected the expression of miR-125b in CRC tissues, subsequently investigated the effect of miR-125b on the proliferation, apoptosis, cell cycle and metastasis on CRC cells. Our results showed that the expression of miR-125b was significantly decreased in CRC tissues comparing to adjacent tissues. However, with the stimulation of Granulocyte colony-stimulating factor (G-CSF), which was highly expressed in CRC tissues, the expression of miR-125b could be improved...
August 1, 2017: Oncotarget
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