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Lymphoscintigraphy

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https://www.readbyqxmd.com/read/28214496/new-diagnostic-modalities-in-the-evaluation-of-lymphedema
#1
REVIEW
Thomas F O'Donnell, John C Rasmussen, Eva M Sevick-Muraca
OBJECTIVE: Currently, lymphedema (LED) is typically diagnosed clinically on the basis of a patient's history and characteristic physical findings. Whereas the diagnosis of LED is sometimes confirmed by lymphoscintigraphy (LSG), the technique is limited in both its ability to identify disease and to guide therapy. Recent advancements provide opportunities for new imaging techniques not only to assist in the diagnosis of LED, based on anatomic changes, but also to assess contractile function and to guide therapeutic intervention...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28175934/investigating-the-role-of-spect-ct-in-dynamic-sentinel-lymph-node-biopsy-for-penile-cancers
#2
Ziauddin Zia Saad, Savvas Omorphos, Sofia Michopoulou, Svetislav Gacinovic, Peter Malone, Raj Nigam, Asif Muneer, Jamshed Bomanji
PURPOSE: Currently, most centres use 2-D planar lymphoscintigraphy when performing dynamic sentinel lymph node biopsy in penile cancer patients with clinically impalpable inguinal nodes. This study aimed to investigate the role of SPECT/CT following 2-D planar lymphoscintigraphy (dynamic and static) in the detection and localization of sentinel lymph nodes in the groin. METHODS: A qualitative (visual) review was performed on planar followed by SPECT/CT lymphoscintigraphy in 115 consecutive patients (age 28-86 years) who underwent injection of (99m)Tc-nanocolloid followed by immediate acquisition of dynamic (20 min) and early static scans (5 min) initially and further delayed static (5 min) images at 120 min followed by SPECT/CT imaging...
February 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28166148/desirable-properties-of-radiopharmaceuticals-for-sentinel-node-mapping-in-patients-with-breast-cancer-given-the-paradigm-shift-in-patient-management
#3
Chun K Kim, Katherine A Zukotynski
Over the past 2 decades, lymphoscintigraphy and sentinel node biopsy have become widely accepted and are used by surgeons to stage many solid cancers, especially breast cancer. However, despite growing experience, there are a number of unresolved issues. In addition, the impact of a new radiopharmaceutical remains to be determined. The present article addresses some of these issues (either unresolved, recurrent, or newly emerged), with a focus on the properties of radiopharmaceuticals used for sentinel node mapping in breast cancer...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28145970/importance-of-accurate-ilio-inguinal-quantification-in-lower-extremity-lymphoscintigraphy
#4
Georgia Keramida, Nicola Winterman, Emma Wroe, Mark Aplin, A Michael Peters
AIMS: The aims of this study were to improve the quantification of lower extremity lymphoscintigraphy, determine its value and lower limit of normal, and determine whether intermediate postinjection time imaging is necessary. PATIENTS AND METHODS: This was a study of 102 consecutive patients undergoing routine lower extremity lymphoscintigraphy using subcutaneous Tc-99m-nanocolloid with imaging at 5, 45 and 150 min after injection. Abnormal imaging criteria were delay (no activity in ilio-inguinal nodes at 45 min or negligible activity at 150 min), lymph diversion (through skin or deep system) and focal accumulation suggesting cellulitis...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28132110/the-added-value-of-spect-ct-for-the-identification-of-sentinel-lymph-nodes-in-early-stage-oral-cancer
#5
Inne J den Toom, Annelies van Schie, Stijn van Weert, K Hakki Karagozoglu, Elisabeth Bloemena, Otto S Hoekstra, Remco de Bree
PURPOSE: To assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1-T2) oral cancer and a clinically negative neck (cN0). METHODS: In addition to planar lymphoscintigraphy, SPECT-CT was performed in 66 consecutive patients with early stage oral cancer and a clinically negative neck. The addition of SPECT-CT to planar images was retrospectively analyzed for the number of additional SLNs, more precise localization of SLNs, and importance of anatomical information by a team consisting of a nuclear physician, surgeon, and investigator...
January 29, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28128668/animal-models-of-secondary-lymphedema-new-approaches-in-the-search-for-therapeutic-options
#6
Rebecca Hadrian, Daniel Palmes
Secondary lymphedema is still a worldwide problem. Symptomatic approaches to lymphedema therapy have been mainly used, with complete decongestive therapy as the cornerstone. Due to a lack of regenerative therapy, researchers have established various animal models to obtain insights into pathomechanisms and to reveal the best therapeutic option. Since the first reproducible and reliable animal model of lymphedema was reported in dogs, the technique of circumferential excision of lymphatic tissue has been translated mainly to rodents to induce secondary lymphedema...
January 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28117520/is-sentinel-node-biopsy-of-the-internal-mammary-lymph-nodes-relevant-in-the-management-of-breast-cancer
#7
Chuan Tan, Rebecca Caragata, Ian Bennett
The aim of this study was to review the outcomes of a series of breast cancer patients who underwent sentinel node biopsy inclusive of lymphoscintigraphy, and to assess the incidence of internal mammary node (IMN) metastatic positivity at exploration and whether these findings influenced treatment. Between April 2001 and December 2012, 581 breast cancer patients at Princess Alexandra Hospital underwent preoperative lymphoscintigraphy in the course of the performance of sentinel node biopsy. Analysis was performed of those patients who demonstrated radio-isotope uptake to the IMN chain, and who had sentinel node biopsy of the IMN's and were found to have metastatic involvement...
January 24, 2017: Breast Journal
https://www.readbyqxmd.com/read/28102480/dynamic-sentinel-node-biopsy-for-penile-cancer-an-initial-experience-in-an-irish-hospital
#8
P E Lonergan, A Nic An Riogh, F O'Kelly, D J Lundon, D O'Sullivan, M O'Connell, P K Hegarty
BACKGROUND: The presence of nodal metastases is the single most important prognostic factor in penile cancer. However, reliable assessment of nodal status in clinically node-negative (cN0) patients poses a challenge. Approximately 20% of these patients harbour occult nodal metastases. Currently available non-invasive radiological investigations are unreliable in excluding micrometastatic disease. AIM: Dynamic sentinel node biopsy (DSNB) is a minimally invasive procedure for assessing lymph node involvement...
January 19, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28035487/application-of-sentinel-lymph-node-dissection-in-gynecological-cancers-results-of-a-survey-among-german-hospitals
#9
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Matthias Jentschke, Peter Hillemanns
PURPOSE: Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals. METHODS: Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The survey contained 61 questions regarding the SLND in vulvar, cervical, endometrial and ovarian cancer...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28006085/lymphatic-drainage-patterns-of-oral-maxillary-tumors-approachable-locations-of-sentinel-lymph-nodes-mainly-at-the-cervical-neck-level
#10
Koos Boeve, Kees-Pieter Schepman, Bert van der Vegt, Ed Schuuring, Jan L Roodenburg, Adrienne H Brouwers, Max J Witjes
BACKGROUND: There is debate if the lymphatic drainage pattern of oral maxillary cancer is to the retropharyngeal lymph nodes or to the cervical lymph nodes. Insight in drainage patterns is important for the indication for neck treatment. The purpose of this study was to identify the lymphatic drainage pattern of oral maxillary cancer via preoperative lymphoscintigraphy. METHODS: Eleven consecutive patients with oral maxillary cancer treated in our center between December 1, 2012, and April 22, 2016 were studied...
March 2017: Head & Neck
https://www.readbyqxmd.com/read/28005646/lymphoscintigraphic-spect-ct-contralateral-axillary-sentinel-lymph-node-drainage-in-breast-cancer
#11
Ratna T Koyyalamudi, Monica Anne Rossleigh
A 58-year-old woman with previous right breast carcinoma treated with lumpectomy, right axillary clearance, chemo-radiotherapy, and adjuvant hormonal therapy underwent a lymphoscintigraphy for a new right breast lesion. On planar images, an alternate route of lymphatic drainage was observed to the right internal mammary chain and the left axilla. A chest SPECT/CT was performed to confirm the location of the sentinel nodes. The patient underwent a right mastectomy and left axillary sentinel lymph node biopsy, which showed no evidence of lymphovascular invasion...
February 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27993322/lymphoscintigraphy-for-imaging-of-the-lymphatic-flow-disorders
#12
REVIEW
Rie Yagi Yoshida, Shuji Kariya, Sangkil Ha-Kawa, Noboru Tanigawa
Lymphoscintigraphy has introduced with the great advantage for diagnostic imaging of the lymphatic flow disorders. Lymphoscintigraphy can be performed in patients of any age, including neonates, and even in patient in critical conditions. The procedure is quite simple, and it needs only subcutaneous injection of small amounts of radiotracers. From subcutaneous tissue the radiotracer is taken by the lymphatic vessels and gives off energy in the form of gamma radiation detected by a gamma camera. Radiotracers rarely cause the allergic reaction and can be administered to the patients with allergy to iodine contrast media...
December 2016: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/27987230/the-lymphatic-superficial-circumflex-iliac-vessels-deep-branch-perforator-flap-a-new-preventive-approach-to-lower-limb-lymphedema-after-groin-dissection-preliminary-evidence
#13
Stefano Gentileschi, Maria Servillo, Giorgia Garganese, Simona Fragomeni, Francesca De Bonis, Alessandro Cina, Giovanni Scambia, Marzia Salgarello
OBJECTIVE: Groin dissection is the procedure with the highest risk of lower limb lymphedema.As lymph stasis causes irreversible alterations to the limb over time,therapies should be administered in early stages,or better yet, lymphatic drainage impairment should be prevented.We developed a new preventive approach to lymphedema after groin dissection, and we report our preliminary experience. PATIENTS AND METHODS: We enrolled 5 patients undergoing bilateral groin dissection for vulvar cancer...
December 17, 2016: Microsurgery
https://www.readbyqxmd.com/read/27976365/heterotopic-vascularized-lymph-node-transfer-to-the-medial-calf-without-a-skin-paddle-for-restoration-of-lymphatic-function-proof-of-concept
#14
Mark L Smith, Bianca J Molina, Erez Dayan, Diane S Saint-Victor, Julie N Kim, Eugene S Kahn, Alexander Kagen, Joseph H Dayan
BACKGROUND: The use of heterotopic vascularized lymph node transfer (HVLNT) for the treatment of lower extremity lymphedema is still evolving. Current techniques, either place the lymph nodes in the thigh without a skin paddle or at the ankle requiring an unsightly and often bulky skin paddle for closure. We explored the feasibility of doing a below-knee transfer without a skin paddle using the medial sural vessels as recipient vessels and report our experience in 21 patients. METHODS: A retrospective review of all patients who underwent HVLNT to the medial calf was performed...
January 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27915052/massive-localized-lymphedema-a-case-control-study
#15
Reid Maclellan, David Zurakowski, Frederick D Grant, Arin K Greene
BACKGROUND: Massive localized lymphedema (MLL) is an area of skin and subcutaneous overgrowth associated with obesity. The purpose of this project was to determine whether MLL results from obesity-induced lymphedema (OIL), and to characterize the prevalence and risk factors for the condition. STUDY DESIGN: Patients evaluated in our Lymphedema Program between 2009 and 2016 were reviewed for obese individuals [body mass index (BMI) > 30 kg/m(2)] who had lower extremity lymphatic function evaluated by lymphoscintigraphy...
November 10, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27911477/vascularized-appendicular-lymph-node-transfer-for-treatment-of-extremity-lymphedema-a-case-report
#16
Pedro Ciudad, Oscar J Manrique, Shivprasad Date, Wei-Ling Chang, Fabio Nicoli, Stamatis Sapountzis, Hsu-Tang Cheng, Mouchammed Agko, Hung-Chi Chen
Vascularized lymph node transfer has demonstrated promising results for the treatment of extremity lymphedema. In an attempt to find the ideal donor site, several vascularized lymph nodes have been described. Each has a common goal of decreasing morbidity and avoiding iatrogenic lymphedema while obtaining good clinical results. Herein, we present the preliminary clinical outcomes of an intra-abdominal lymph node flap option based on the appendicular artery and vein used for the treatment of extremity lymphedema...
December 2, 2016: Microsurgery
https://www.readbyqxmd.com/read/27893540/eight-years-experience-of-sentinel-lymph-node-biopsy-in-melanoma-using-lymphoscintigraphy-and-gamma-probe-detection-after-radiocolloid-mapping
#17
Nathalie Pham Dang, Sophie Cassier, Aurélien Mulliez, Sandrine Mansard, Michel DʼIncan, Isabelle Barthélémy
BACKGROUND: Isosulfan blue dye peripheral injection is used in preoperative sentinel lymph node (SLN) identification alone or, to increase sensitivity, in conjunction with radiocolloid mapping. However, isosulfan blue dye has certain drawbacks and limitations. OBJECTIVE: This study assesses the authors' experience of SLN biopsy using only radiocolloid tracer. MATERIALS AND METHODS: Between 2000 and 2008, 218 patients underwent SLN biopsy with radiocolloid mapping, preoperative localization by lymphoscintigraphy and intraoperative confirmation by gamma probe in primary malignant cutaneous melanoma...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27878928/sentinel-lymph-node-biopsy-for-early-oral-cancers-westmead-hospital-experience
#18
Muzib Abdul-Razak, Hsiang Chung, Eva Wong, Carsten Palme, Michael Veness, David Farlow, Hedley Coleman, Gary Morgan
BACKGROUND: Sentinel lymph node biopsy (SLNB) has become an alternative option to elective neck dissection (END) for early oral cavity squamous cell carcinoma (OCSCC) outside of Australia. We sought to assess the technical feasibility of SLNB and validate its accuracy against that of END in an Australian setting. METHODS: We performed a prospective cohort study consisting of 30 consecutive patients with cT1-2 N0 OCSCC referred to the Head and Neck Cancer Service, Westmead Hospital, Sydney, between 2011 and 2014...
January 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27870709/groin-recurrences-in-node-negative-vulvar-cancer-patients-after-sole-sentinel-lymph-node-dissection
#19
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Peter Hillemanns
OBJECTIVE: This study aimed to evaluate the recurrence rates after sole sentinel dissection in vulvar cancer and describe characteristics of groin recurrences. METHODS: All vulvar cancer cases between 2008 and 2014 were reviewed. Inclusion criteria were restricted to lymph node-negative patients, sole sentinel lymph node dissection (SLND), and tumor diameter less than 4 cm. In all patients, Tc-99m nanocolloid was used for preoperative SLN imaging. Regularly, planar lymphoscintigraphy and single-photon emission computed tomography with computed tomography were performed...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27863028/utility-of-hybrid-spect-ct-in-primary-melanoma-lymphoscintigraphy-a-retrospective-case-series
#20
Khimling Tew, David Farlow
INTRODUCTION: Sentinel lymph node (SLN) biopsy is widely accepted as an important part of staging cutaneous malignant melanoma. Hybrid single photon emission computed tomography and computed tomography (SPECT/CT) may identify additional SLN and provide important information to the surgeon performing SLN biopsy. We report our experience at a major referral centre for melanoma surgery. METHODS: Retrospective case series of pre-operative sentinel node lymphoscintigraphy for primary melanoma over a consecutive 12-month period...
November 14, 2016: Journal of Medical Imaging and Radiation Oncology
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