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Lymphoscintigraphy

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https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#1
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29762449/time-to-procedure-nuclear-imaging-and-clinicopathological-characteristics-as-predictive-factors-for-sentinel-lymph-node-metastasis-in-cutaneous-melanoma-a-single-center-analysis
#2
Ljiljana Jaukovic, Milica Rajović, Lidija Kandolf Sekulovic, Marija Radulovic, Nenad Stepic, Zeljko Mijuskovic, Nenad Petrov, Boris Ajdinovic
OBJECTIVE: Sentinel lymph node (SLN) biopsy is a widely accepted staging procedure for cutaneous melanoma patients who are at risk of clinically occult nodal metastases. Numerous predictive factors for regional lymph node metastases have been identified; however, few have been found to be reproducibly significant. Also, the role of blue dye in identification was questioned in recent trials. Time to procedure was also found to be predictive of SLN positivity, but this was not confirmed in other studies...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762243/primary-congenital-lymphedema
#3
Lubomir Mrhac, Kamil Bukovansky, Jana Kafkova, Otakar Kraft
We present the case of a 26-year-old man with congenital primary lymphedema. A lymphedema of the right upper limb appeared at the age of 2 years, followed by edemas of the right lower limb and of the right part of the head and neck. A lymphedema of the left lower limb began 5 years ago, and finally an edema of the external genitalia began 2 years ago. Lymphoscintigraphy of the lower limbs and pelvic/abdominal region (including SPECT/ldCT) revealed interesting abnormalities.
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29752013/-lymphedema-in-patients-treated-with-sirolimus-15-cases
#4
C Fourgeaud, L Simon, B Benoughidane, S Vignes
BACKGROUND: Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor used after organ transplantation and to treat vascular malformations. Among its adverse effects, limb lymphedema has been described. OBJECTIVE: The aim of this study was to analyze the clinical features, lymphoscintigraphy and lymphedema outcome in patients treated with sirolimus. PATIENTS AND METHODS: Monocentric retrospective study from January 2008 to September 2017 analyzing all consecutive patients having lymphedema occurring with sirolimus...
May 8, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29728517/a-first-in-man-study-of-68-ga-nanocolloid-pet-ct-sentinel-lymph-node-imaging-in-prostate-cancer-demonstrates-aberrant-lymphatic-drainage-pathways
#5
Jacki A Doughton, Michael S Hofman, Peter Eu, Rodney J Hicks, Scott G Williams
Purpose: To assess feasibility, safety and utility of a novel 68 Ga-nanocolloid radio-tracer with PET-CT lymphoscintigraphy for identification of sentinel lymph nodes (SLN). Methods: Pilot study of patients from a tertiary cancer hospital who required insertion of gold fiducials for prostate cancer radiation therapy. Participation did not affect cancer management. Ultrasound-guided transperineal intra-prostatic injection of PET tracer (iron oxide nanocolloid labelled with gallium-68) after placement of fiducials...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29718857/surgical-management-of-tumor-positive-interval-node-in-melanoma-patients-an-observational-study
#6
Eleonora Nacchiero, Michelangelo Vestita, Fabio Robusto, Michele Maruccia, Paolo Annoscia, Giuseppe Giudice
The presence of interval nodes (IN) in melanoma is testified in several studies and sometimes these lymph nodes can contain metastatic disease. Currently there are no guidelines about the management of patients with tumor-positive INs.We enrolled all patients affected by melanoma who underwent sentinel lymph node biopsy (SLNB) in a single institution. All patients with tumor-positive IN underwent the lymphadenectomy of the subsequent draining lymphatic field. Prognosis of IN+-patients was compared with subjects with positive SLNB in usual field through Kaplan-Meier and multivariate Cox regression analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29707448/eliminating-preoperative-lymphoscintigraphy-in-extremity-melanomas
#7
Andrew McGregor, Sabrina N Pavri, Samuel Kim, Xiaolu Xu, Deepak Narayan
Background: Preoperative lymphoscintigraphy (LSG) is an imaging procedure routinely used to identify the draining nodal basin in melanomas. At our institute, we have traditionally performed preoperative LSG followed by intraoperative LSG for logistical and evaluative reasons. We sought to determine if preoperative LSG could be safely eliminated in the treatment of extremity melanomas, which exhibit consistent and predictable lymphatic drainage patterns. Methods: We reviewed the Yale Melanoma Registry 1308012545 for cutaneous extremity melanomas treated at our institution...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29700776/a-novel-application-of-indocyanine-green-immunofluorescence-in-emergent-colorectal-surgery
#8
Deborah S Keller, Richard Boulton, Manuel Rodriguez-Justo, Richard Cohen, Manish Chand
Here, we report on the feasibility of ICG fluorescence imaging to localize lesions in emergent minimally invasive surgery. A 49-year old female presented to the emergency department with a previously unknown malignant bowel obstruction. She was taken emergently to the operating room for a laparoscopic extended right hemicolectomy, based on tumor location from imaging. With intraoperative difficulty localizing the lesion, an on-table colonoscopy was performed. When the tumor was encountered, peritumoral ICG injections were performed, and the fluorescence lymphoscintigraphy was performed intraoperatively in an attempt to visualize the primary tumor laparoscopically...
April 26, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29696442/the-best-of-both-worlds-a-hybrid-approach-for-optimal-pre-and-intraoperative-identification-of-sentinel-lymph-nodes
#9
G H KleinJan, E van Werkhoven, N S van den Berg, M B Karakullukcu, H J M A A Zijlmans, J A van der Hage, B A van de Wiel, T Buckle, W M C Klop, S Horenblas, R A Valdés Olmos, H G van der Poel, F W B van Leeuwen
PURPOSE: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-99m Tc-nancolloid was evaluated in a large cohort of patients. PATIENTS AND METHODS: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer)...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29601572/brugia-malayi-infection-in-ferrets-a-small-mammal-model-of-lymphatic-filariasis
#10
Belinda M Jackson-Thompson, So Young Kim, Shalini Jaiswal, Jessica R Scott, Scott R Jones, C Paul Morris, J Judd Fite, Karen Laurie, Andrew R Hoy, Bernard J Dardzinski, Edward Mitre
BACKGROUND: The lack of effective short-course therapies for treatment of the adult stage of filarial worms is a major limitation in the global effort to eliminate lymphatic filariasis. Studies using current small mammal models of lymphatic filariasis are limited by difficulties in quantifying adult worm numbers and in assessing lymphatic anatomy and function. METHODOLOGY/PRINCIPAL FINDINGS: Here, we re-established Brugia malayi infection of ferrets as a model for lymphatic filariasis and demonstrated parasitological, immunological, and histological parallels with human infection...
March 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29595571/targeted-ultrasound-and-fine-needle-aspiration-cytology-for-sentinel-node-diagnostics-in-early-stage-melanoma-a-validation-study
#11
Niels K Ternov, Trine-Lise Lambine, Anne L H Wagenblast, Erik Clasen-Linde, Peter S Oturai, Helle Klyver, Kristina R Nielsen, Michael B Nielsen, Krzysztof T Drzewiecki, Annette H Chakera
Ultrasound-guided fine-needle aspiration cytology (US-FNAC) is used to evaluate the involvement of lymph nodes in various malignant diseases. Its value in detecting sentinel lymph node (SN) metastasis preoperatively in melanoma patients is controversial and is the subject of this study. In this prospective validation study, 91 consecutive patients with melanoma clinical stage I (n=64) and II (n=27) were examined with US-FNAC before SN biopsy from 2012 to 2014 at a tertiary center. All patients underwent lymphoscintigraphy before the US-FNAC...
March 27, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29589645/chronic-peripheral-edema-in-a-patient-with-rheumatoid-arthritis
#12
Vesna Breznik, Klara Dai, Maruška Marovt
Chronic peripheral edema is a very common yet underestimated problem. It is of utmost importance to investigate various possible causes and understand the pathophysiological mechanisms of chronic peripheral edema in order to determine the optimal treatment. This case report presents the case of a polymorbid patient with a deformity-causing type of rheumatoid arthritis and a 1-year history of progressive symmetrical peripheral edema. Based on an extensive diagnostic investigation, the patient was diagnosed with a combined form of chronic peripheral edema comprised of true lymphedema, which was confirmed by lymphoscintigraphy, and filtration edema due to muscular inactivity...
March 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/29575685/high-sensitivity-and-negative-predictive-value-of-sentinel-lymph-node-biopsy-in-a-retrospective-early-stage-oral-cavity-cancer-cohort-in-the-northern-netherlands
#13
K Boeve, K P Schepman, E Schuuring, J L N Roodenburg, G B Halmos, B A C van Dijk, R A C Boorsma, J G A M de Visscher, A H Brouwers, B van der Vegt, M J H Witjes
OBJECTIVES: In cT1-2N0 oral squamous cell carcinoma (OSCC) occult metastases are detected in 23 - 37% of cases. Sentinel lymph node biopsy (SLNB) was introduced in head and neck cancer as a minimally invasive alternative for an elective neck dissection in neck staging. Meta-analyses of SLNB accuracy shows heterogeneity in the existing studies for reference standards, imaging techniques and pathological examination. The aim of this study was to assess the sensitivity and negative predictive value (NPV) of the SLNB in detecting occult metastases in cT1-2N0 OSCC in a well-defined cohort...
March 25, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29570125/improvement-to-visualization-of-nodes-in-breast-cancer-patients-following-audit-are-we-seeing-the-problem
#14
Carolyn L Paterson, Fraser R Hendry, Alison A Bolster
Successful localization of nodes in breast cancer patients depends upon the effectiveness of the lymphoscintigraphy technique employed. A benefit of performing imaging as part of this procedure is that it allows sites to audit their technique. An audit of breast cancer patients at the Glasgow Royal Infirmary (GRI) hospital showed nodes to be visualized in only 81% of patients. Current guidelines state that nodes should be seen in more than 95% of patients. A period of investigation and review led to changes being made to the injection and imaging technique employed at the GRI site...
March 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29550286/orthotopic-transfer-of-vascularized-groin-lymph-node-flap-in-the-treatment-of-breast-cancer-related-lymphedema-clinical-results-lymphoscintigraphy-findings-and-proposed-mechanism
#15
Hin-Lun Liu, Suet-Ying Pang, Chung-Ching Lee, Melody Man-Kuen Wong, Hon-Ping Chung, Yu-Wai Chan
INTRODUCTION: Vascularized lymph node transfer (VLNT) has become very popular in the treatment of secondary lymphedema. However, the mechanism has not been clearly elucidated. The purpose of this study was (1) to evaluate the outcome of vascularized groin lymph node (VGLN) transfer using axilla as a recipient site in patients with breast cancer-related lymphedema (BCRL) and (2) to provide radiological evidence of lymphangiogenesis in VLNT. METHODS: Between August 2013 and June 2016, 30 consecutive patients with a mean age of 60 years underwent VGLN transfer for BCRL...
February 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29527377/lymphatic-drainage-of-legs-reduces-edema-of-the-arms-in-children-with-lymphedema
#16
Lívia Maria Pereira de Godoy, Paula Pereira de Godoy Capeletto, Maria de Fátima Guerreiro Godoy, Jose Maria Pereira de Godoy
Objective: The aim of the present study is to report on the reduction of edema of lymphedematous arms just by treating the lower limbs. Methods: A 16-year-old girl reported that she has started having right lower limb edema at the age of three. At age 13, she performed a lymphoscintigraphy that confirmed the diagnosis of primary lymphedema of the four limbs. Recently she sought treatment at the Clínica Godoy in São Jose do Rio Preto where she was submitted to intensive treatment for eight hours per day for five days using manual (Godoy & Godoy technique) and mechanical lymphatic therapy (RA Godoy® ) of the lower limbs, cervical lymphatic therapy (cervical stimulation), and the continuous use of a grosgrain stocking...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29518822/double-vascularized-omentum-lymphatic-transplant-volt-for-the-treatment-of-lymphedema
#17
Elizabeth O Kenworthy, Jonas A Nelson, Richa Verma, JeanJacques Mbabuike, Babak J Mehrara, Joseph H Dayan
BACKGROUND AND OBJECTIVES: Orthotopic vascularized lymph node transplant has been successfully used to treat lymphedema. A second, heterotopic lymph node transplant in the distal extremity may provide further improvement. The vascularized omentum lymphatic transplant (VOLT) provides adequate tissue for two simultaneous flap transfers to one limb. The purpose of this study was to review our experience with this technique. METHODS: We conducted a retrospective study of patients who underwent VOLT, with a subgroup analysis of patients who underwent double VOLT...
March 8, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29510266/what-about-sentinel-lymph-node-biopsy-for-early-breast-cancer-during-pregnancy
#18
V Balaya, H Bonsang-Kitzis, C Ngo, M Delomenie, M Gosset, M Mimouni, C Nos, P M David, A S Bats, F Lecuru
Pregnancy-associated breast cancer is rare, but this clinical situation arises in 1/10,000-1/3000 pregnancies. In patients presenting an early-stage breast tumor devoid of clinically pathological lymph node, sentinel lymph node (SLN) biopsy has not yet been validated as a routine procedure for pregnant women due to the lack of data in the literature. The blue dye injection is not recommended because of 2% theoretical risk of anaphylactic shock. Several studies have shown that Tc99m injection at conventional dose between 12...
May 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29445878/feasibility-of-intraoperative-detection-of-sentinel-lymph-nodes-with-89-zirconium-labelled-nanocolloidal-albumin-pet-ct-and-a-handheld-high-energy-gamma-probe
#19
Derrek A Heuveling, K Hakki Karagozoglu, Arthur Van Lingen, Otto S Hoekstra, Guus A M S Van Dongen, Remco De Bree
BACKGROUND: PET/CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary tumour. This study aims to demonstrate the feasibility of PET/CT lymphoscintigraphy followed by intraoperative detection of 89 Zr-nanocolloidal albumin containing SLNs with the use of a handheld high-energy gamma probe. METHODS: PET/CT lymphoscintigraphy was performed after peritumoural injection of 89 Zr-nanocolloidal albumin in five patients with oral cavity carcinoma planned for surgical resection...
February 14, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29438650/updated-evidence-based-clinical-practice-guidelines-for-the-diagnosis-and-management-of-melanoma-definitive-excision-margins-for-primary-cutaneous-melanoma
#20
Michael J Sladden, Omgo E Nieweg, Julie Howle, Brendon J Coventry, John F Thompson
Definitive management of primary cutaneous melanoma consists of surgical excision of the melanoma with the aim of curing the patient. The melanoma is widely excised together with a safety margin of surrounding skin and subcutaneous tissue, after the diagnosis and Breslow thickness have been established by histological assessment of the initial excision biopsy specimen. Sentinel lymph node biopsy should be discussed for melanomas ≥ 1 mm thickness (≥ 0.8 mm if other high risk features) in which case lymphoscintigraphy must be performed before wider excision of the primary melanoma site...
February 19, 2018: Medical Journal of Australia
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