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https://www.readbyqxmd.com/read/29793056/high-myristic-acid-content-in-the-cyanobacterium-cyanothece-sp-pcc-8801-results-from-substrate-specificity-of-lysophosphatidic-acid-acyltransferase
#1
Masakazu Saito, Kaichiro Endo, Koichi Kobayashi, Mai Watanabe, Masahiko Ikeuchi, Akio Murakami, Norio Murata, Hajime Wada
Analysis of fatty acids from the cyanobacterium Cyanothece sp. PCC 8801 revealed that this species contained high levels of myristic acid (14:0) and linoleic acid in its glycerolipids, with minor contributions from palmitic acid (16:0), stearic acid, and oleic acid. The level of 14:0 relative to total fatty acids reached nearly 50%. This 14:0 fatty acid was esterified primarily to the sn-2 position of the glycerol moiety of glycerolipids. This characteristic is unique because, in most of the cyanobacterial strains, the sn-2 position is esterified exclusively with C16 fatty acids, generally 16:0...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29792976/simultaneous-bilateral-ureteral-calculi-a-new-paradigm-for-management
#2
Kymora B Scotland, Scott G Hubosky, Ryuta Tanimoto, Robert Cooper, Kelly A Healy, Demetrius H Bagley
OBJECTIVES: To define the need for emergent intervention between patients with SBUC compared to unilateral ureteral calculi (UUC). Patients with simultaneous bilateral ureteral calculi (SBUC) represent a potential urological emergency due to possible anuria and/or electrolyte imbalance. While conventional practice mandates immediate intervention in these patients, little data exist to define the rate of these events. METHODS: Records of all patients with ureteral stones treated ureteroscopically over an 11-year period were reviewed to identify those with SBUC...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792898/energy-drink-exposures-reported-to-texas-poison-centers-analysis-of-adverse-incidents-in-relation-to-total-sales-2010-2014
#3
Stephen W Borron, Susan H Watts, Jessica Herrera, Joshua Larson, Salvador Baeza, Richard L Kingston
The ill-defined term "energy drink" includes a disparate group of products (beverages, shots, concentrates, and workout powders) having large differences in caffeine content and concentration and intended use. Hence, inaccurate conclusions may be drawn when describing adverse events associated with "energy drinks". The FDA is considering new regulation of these products but product specificity is needed to evaluate safety. To help address this, we queried Texas Poison Center Network data for single substance exposures to "energy drinks" from 2010 to 2014, then analyzed adverse events by product type...
May 21, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29792869/preferential-inputs-from-cholecystokinin-positive-neurons-to-the-somatic-compartment-of-parvalbumin-expressing-neurons-in-the-mouse-primary-somatosensory-cortex
#4
Hiroyuki Hioki, Jaerin Sohn, Hisashi Nakamura, Shinichiro Okamoto, Jungwon Hwang, Yoko Ishida, Megumu Takahashi, Hiroshi Kameda
Parvalbumin-positive (PV+) neurons in the cerebral cortex, mostly corresponding to fast-spiking basket cells, have been implicated in higher-order brain functions and psychiatric disorders. We previously demonstrated that the somatic compartment of PV+ neurons received inhibitory inputs mainly from vasoactive intestinal polypeptide (VIP)+ neurons, whereas inhibitory inputs to the dendritic compartment were derived mostly from PV+ and somatostatin (SOM)+ neurons. However, a substantial number of the axosomatic inputs have remained unidentified...
May 21, 2018: Brain Research
https://www.readbyqxmd.com/read/29792583/educator-sexual-misconduct-and-texas-educator-discipline-database-construction
#5
Catherine E Robert, David P Thompson
The purpose of this research is to describe Texas educator sexual misconduct (ESM) by examining 8 years of sanctions issued to educators (N = 1415) for either sexual misconduct or inappropriate relationships with students or minors. We first examine Texas ESM from the perspective of quality database construction and then describe the demographic characteristics of educators sanctioned for ESM between 2008 and 2016. Differences in the demographic characteristics of educators sanctioned for ESM vary according to the definition of ESM employed by the state education agency...
May 24, 2018: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29792494/fostering-youth-self-efficacy-to-address-transgender-and-racial-diversity-issues-the-role-of-gay-straight-alliances
#6
Eddie S K Chong, V Paul Poteat, Hirokazu Yoshikawa, Jerel P Calzo
Gay-Straight Alliances (GSAs) aspire to empower youth to address multiple systems of oppression, including those affecting transgender and racial/ethnic minority youth, yet there is little indication of factors contributing to youths' self-efficacy to do so. We examined individual and group factors predicting self-efficacy to address transgender and racial issues among 295 youth in 33 high school GSAs. Multilevel results indicated that level of GSA engagement, individual and collective involvement in transgender- and race-specific discussions, and in some cases intergroup friendships were associated with each form of self-efficacy...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792487/ethnic-racial-typicality-and-its-relation-to-ethnic-identity-and-psychological-functioning
#7
Lauren L Mitchell, Ummul-Kiram Kathawalla, Alex A Ajayi, Jillian Fish, Sarah C Nelson, Lovey H M Peissig, Moin Syed
OBJECTIVES: Ethnic identity development is considered a central task of adolescence and emerging adulthood for ethnic minority individuals. Although the process of developing a coherent ethnic identity has received attention from researchers, there has been little work done to elucidate the content of ethnic identity. This study uses an inductive mixed-methods approach to address 1 aspect of ethnic identity content: typicality, or the degree of perceived similarity individuals feel to their ethnic-racial group...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792486/okay-to-say-initial-validation-of-the-acceptability-of-racial-microaggressions-scale
#8
Yara Mekawi, Nathan R Todd
Despite a growing body of research documenting the negative impact of racial microaggressions on racial and ethnic minorities' wellbeing, there remains debate in society about whether it is acceptable to say racially microaggressive statements. However, no scale exists to assess attitudes about the acceptability of saying such statements. OBJECTIVES: In this study we present an initial validation of a new scale, the Acceptability of Racial Microaggressions Scale (ARMS), which assesses attitudes about how "okay" it is for White individuals to say different types of racially microaggressive statements to racial and ethnic minorities in an interpersonal interaction...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792484/-a-threat-on-the-ground-the-consequences-of-witnessing-stereotype-confirming-ingroup-members-in-interracial-interactions
#9
Valerie Jones Taylor, Randi L Garcia, J Nicole Shelton, Caitlyn Yantis
OBJECTIVES: Three studies explored interpersonal consequences of engaging in interracial interactions after witnessing racial ingroup members' stereotypical behavior. METHOD: Study 1 used experience-sampling methodology to assess ethnic minority students' (n = 119) intergroup anxiety, metastereotypes, and anticipatory behaviors following one of three types of interpersonal interactions: (a) a White person and a racial ingroup member who had behaved stereotypically, (b) a White person and a nonstereotypical ingroup member, or (c) neither...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792479/-fewer-but-not-weaker-understanding-the-intersectional-identities-among-chinese-immigrant-young-gay-men-in-toronto
#10
Yu-Te Huang, Lin Fang
Sexual minorities of color in North America are frequently defined as a "double minority" group. Intersectionality theory has inspired investigations into how different forms of marginalization intersect to shape the lives of people with multiple minority statuses. In this constructivist grounded theory study, 18 Chinese immigrant gay men between 18 and 28 years of age participated in a semistructured individual interview to narrate their lived experiences in relation to their intersectional identities...
May 24, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29792330/vancomycin-determination-by-disrupting-electron-transfer-in-a-fluorescence-turn-on-squaraine-anthraquinone-triad
#11
Shue Mei Ng, Xiangyang Wu, M Faisal Khyasudeen, Pawel Jacek Nowakowski, Howe-Siang Tan, Bengang Xing, Edwin K L Yeow
A highly sensitive and selective probe for Vancomycin (Van) in aqueous and serum samples is developed in this study. The probe is based on a triad consisting of a near-infrared squaraine dye (Seta-640) conjugated to two anthraquinone molecules via Lys-D-Ala-D-Ala peptides. In the absence of Van, the close proximity and efficient electron-transfer from the excited Seto-640 dye to anthraquinone result in significant fluorescence quenching of the dye ("off"-state). When Van is added, the antibiotic molecules bind with high affinity to the -D-Ala-D-Ala ligands in a 2:1 stoichiometry (Van:triad); resulting in fluorescence recovery that is as high as 30-times ("on"-state)...
May 24, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29792329/residual-complexity-does-impact-organic-chemistry-and-drug-discovery-the-case-of-rufomyazine-and-rufomycin
#12
Mary P Choules, Larry L Klein, David C Lankin, James B McAlpine, Sang-Hyun Cho, Jinhua Cheng, Hanki Lee, Joo-Won Suh, Birgit U Jaki, Scott G Franzblau, Guido F Pauli
Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromatographic separation methods. The new diketopiperazine, rufomyazine (6), and the previously known antibiotic, rufomycin (7), represent a prototypical case of RC that (almost) resulted in the misassignment of biological activity. The case exemplifies that impurities well below the natural abundance of 13 C (1...
May 24, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29792260/widening-participation-of-m%C3%A4-ori-and-pasifika-students-in-health-careers-evaluation-of-two-health-science-academies
#13
Lesley Middleton, Ausaga Faasalele Tanuvasa, Megan Pledger, Nicola Grace, Kirsten Smiler, Tua Taueetia Loto-Su'a, Jacqueline Cumming
Objective The aim of the present study was to evaluate the short-term outcomes of two health science academies established by a district health board in South Auckland, New Zealand, to create a health workforce pipeline for local Māori and Pasifika students. Methods A mixed-methods approach was used, involving background discussions with key informants to generate an initial logic model of how the academies work, followed by secondary analysis of students' records relating to retention and academic achievement, a survey of senior academy students' interest in particular health careers and face-to-face interviews and focus groups with students, families and teachers...
May 24, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29792253/genocide-rape-trauma-a-conceptual-framework-for-understanding-the-psychological-suffering-of-rwandan-survivors
#14
Donatilla Mukamana, Anthony Collins, William E Rosa
In 1994, the Rwandan genocide claimed the lives of approximately 1 million Tutsi and moderate Hutu citizens. Systematic rape was a strategic component of the Hutu extremist plan to eradicate the Tutsi minority population. This involved collective and repeated sexual assaults with brutal violence, public humiliation, and torture. This article maps the ongoing psychological impact on Rwandan genocide rape survivors and identifies implications for international nursing practice. The research formalizes their narratives, identifying a number of interconnected elements that combine to produce myriad forms of chronic psychological suffering in the Rwandan context...
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29792132/relationships-of-musculoskeletal-symptoms-sociodemographics-and-body-mass-index-with-leisure-time-physical-activity-among-nurses
#15
Soohyun Nam, MinKyoung Song, Soo-Jeong Lee
Nurses have a high prevalence of musculoskeletal symptoms from patient handling tasks such as lifting, transferring, and repositioning. Comorbidities such as musculoskeletal symptoms may negatively affect engagement in leisure-time physical activity (LTPA). However, limited data are available on the relationship between musculoskeletal symptoms and LTPA among nurses. The purpose of this study was to describe musculoskeletal symptoms and LTPA, and to examine the relationships of musculoskeletal symptoms, sociodemographics, and body mass index with LTPA among nurses...
May 1, 2018: Workplace Health & Safety
https://www.readbyqxmd.com/read/29792056/placenta-in-intrauterine-fetal-demise-iufd-a-comprehensive-study-from-a-tertiary-care-hospital
#16
Anisha Manocha, Gayatri Ravikumar, Julian Crasta
BACKGROUND: Intrauterine fetal demise (IUFD) is an unpredictable and challenging obstetric complication. Its etiology is multifactorial with more than 60% attributed to the placental cause. The present study was done with a primary objective of understanding the placental lesions underlying IUFD. METHODS: In this retrospective observational study, IUFD cases (> 22 weeks) between January 2012-September 2015 were collected from pathology database. The clinical details with ultrasound findings were collected from mother's charts...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29791933/infantile-basal-ganglia-stroke-after-mild-head-trauma-associated-with-mineralizing-angiopathy-of-lenticulostriate-arteries-an-under-recognized-entity
#17
Sandra P Toelle, Tamara Avetisyan, Nune Kuyumjyan, Biayna Sukhudyan, Eugen Boltshauser, Annette Hackenberg
Basal ganglia infarction in young children, mostly after mild head trauma, has been repeatedly reported. The pathogenesis and the risk factors are not fully understood. Lenticulostriate vasculopathy, usually referred to as basal ganglia calcification, is discussed as one of them. We describe five young (7-13 months old on presentation) male children who suffered from hemiparesis due to ischemic stroke of the basal ganglia, four of them after minor head trauma. All of them had calcification in the basal ganglia visible on computed tomography or cranial ultrasound but not on magnetic resonance imaging...
May 23, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29791785/expressed-exome-capture-sequencing-eecseq-a-method-for-cost-effective-exome-sequencing-for-all-organisms
#18
Jonathan B Puritz, Katie E Lotterhos
Exome capture is an effective tool for surveying the genome for loci under selection. However, traditional methods require annotated genomic resources. Here, we present a method for creating cDNA probes from expressed mRNA, which are then used to enrich and capture genomic DNA for exon regions. This approach, called "EecSeq", eliminates the need for costly probe design and synthesis. We tested EecSeq in the eastern oyster, Crassostrea virginica, using a controlled exposure experiment. Four adult oysters were heat shocked at 36° C for 1 hour along with four control oysters kept at 14° C...
May 23, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29791702/all-inside-technique-for-acl-reconstruction-using-a-flipcutter%C3%A2-and-the-tightrope%C3%A2-system
#19
Nicos Papaloucas
There have been many innovations in the field of ACL-reconstruction over the years, including the FlipCutter® and TightRope® system (both from Arthrex Inc.). The FlipCutter® is a combined guide pin and reamer that allows minimally invasive socket-creation from the inside out, especially in difficult-to-reach areas. The TightRope® is a further development of the well-known Endobutton™ (Smith & Nephew plc) that consists of a four-point knotless locking system. Its main advantage is its adjustability, which makes it possible to fill the entire bone socket with the graft without any empty space...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791233/association-of-a-chromosome-locus-9p21-3-cdkn2b-as1-variant-rs4977574-with-hypertension-the-tamrisk-study
#20
Tarja Kunnas, Jaakko Piesanen, Seppo T Nikkari
AIMS: Chromosome locus 9p21.3 CDKN2B antisense RNA 1 (CDKN2B-AS1) has been found to contain multiple genetic markers for coronary artery disease (CAD) by genome-wide association studies (GWAS). Of these, the association of variants rs4977574, rs10757274, and rs2383206 with hypertension was studied in the Tampere adult population cardiovascular risk study (TAMRISK). MATERIALS AND METHODS: A Finnish cohort of 336 subjects diagnosed with hypertension and 444 controls was analyzed...
May 2018: Genetic Testing and Molecular Biomarkers
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