keyword
MENU ▼
Read by QxMD icon Read
search

Minority

keyword
https://www.readbyqxmd.com/read/28655137/alzheimer-s-disease-genetics-and-abca7-splicing
#1
Jared B Vasquez, James F Simpson, Ryan Harpole, Steven Estus
Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer's disease (AD). In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ∼1.9. To probe the role of this polymorphism in ABCA7 splicing, we used minigene studies and qPCR of human brain RNA. We report aberrant ABCA7 exon 41 splicing in the brain of a carrier of the rs200538373 minor C allele. Moreover, minigene studies show that rs200538373 acts as a robust functional variant in vitro...
June 22, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28655091/-outcomes-of-lenalidomide-based-treatment-for-57-patients-of-relapsed-or-refractory-multiple-myeloma
#2
S H Deng, Y Xu, W W Sui, G An, X H Mao, Z J Li, D H Zou, L G Qiu
Objective: To investigate the clinical efficacy and safety of lenalidomide (Revlimid, R) -based chemotherapy in the treatment of relapsed/refractory multiple myeloma (MM) patients. Methods: 57 consecutively relapsed/refractory MM patients were retrospectively analyzed from June 2013 to February 2016. All the patients received lenalidomide-based chemotherapy. Results: ① 60.4% patients had international staging system (ISS) stage Ⅲ, 37.9% patients had revised international staging system (R-ISS) stage Ⅲ, and 53...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28655017/prevalence-and-ethnic-pattern-of-diabetes-and-prediabetes-in-china-in-2013
#3
Limin Wang, Pei Gao, Mei Zhang, Zhengjing Huang, Dudan Zhang, Qian Deng, Yichong Li, Zhenping Zhao, Xueying Qin, Danyao Jin, Maigeng Zhou, Xun Tang, Yonghua Hu, Linhong Wang
Importance: Previous studies have shown increasing prevalence of diabetes in China, which now has the world's largest diabetes epidemic. Objectives: To estimate the recent prevalence and to investigate the ethnic variation of diabetes and prediabetes in the Chinese adult population. Design, Setting, and Participants: A nationally representative cross-sectional survey in 2013 in mainland China, which consisted of 170 287 participants. Exposures: Fasting plasma glucose and hemoglobin A1c levels were measured for all participants...
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28654891/relationship-between-the-tert-tnip1-and-obfc1-genetic-polymorphisms-and-susceptibility-to-colorectal-cancer-in-chinese-han-population
#4
Chuang Li, Zixuan Zhao, Jun Zhou, Ying Liu, Hao Wang, Xinhan Zhao
Colorectal cancer (CRC) is one of the most common diseases worldwide, and telomere length has been reported correlate with CRC. This study aimed to investigate whether polymorphisms of telomere length related genes are associated with susceptibility to CRC in Chinese Han population. 11 SNPs from TERT, TNIP1 and OBFC1 genes were selected and genotyped, in addition odds ratio (OR) and 95% confidence intervals (CI) were used to evaluate association between the SNPs and CRC risk in 247 patients clinically and 300 controls in a Chinese Han population...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654855/clinical-profile-and-neurodevelopmental-outcome-of-new-onset-acute-symptomatic-seizures-in-children
#5
Vimlesh Soni, Pratibha Singhi, Arushi Gahlot Saini, Prabhjot Malhi, Radha K Ratho, Baijayantimala Mishra, Sunit C Singhi
PURPOSE: To study clinical profile, neurodevelopmental outcome and its predictors in children with acute symptomatic seizures (ASS). METHODS: Short-term neurodevelopmental outcome and predictors of poor outcomes were prospectively assessed in 105 consecutive children with ASS aged 3 months-12 years RESULTS: Mean age was 51.2+42.2months (3-144 months); 67.2% were males. Central nervous system (CNS) infection in 82%, status epilepticus in 15.2%, abnormal neuroimaging in 62...
June 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28654804/fatal-and-non-fatal-burn-injuries-with-electrical-weapons-and-explosive-fumes
#6
Mark W Kroll, Mollie B Ritter, Howard E Williams
INTRODUCTION: While generally reducing morbidity and mortality, electrical weapons have risks associated with their usage, including eye injuries and falls. With the presence of explosive fumes or fuels there also exists the possibility of burn injury. METHODS: We searched for cases of fatal and non-fatal major burns with TASER(®) electrical weapon usage where there was a possibility that the weapon ignited the explosion. RESULTS: We confirmed 6 cases of fatal burn injury and 4 cases of major non-fatal burns out of 3...
June 20, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28654705/effective-new-membrane-for-preventing-postthoracotomy-pleural-adhesion-by-surface-water-induction-technology
#7
Akiko Uemura, Mary Nakata, Seijirow Goya, Toshiharu Fukayama, Ryou Tanaka
BACKGROUND: After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. METHODS: Eight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive...
2017: PloS One
https://www.readbyqxmd.com/read/28654582/predictors-classification-and-management-of-umbilical-complications-in-diep-flap-breast-reconstruction
#8
Min-Jeong Cho, Sumeet S Teotia, Nicholas T Haddock
BACKGROUND: In recent years, the deep inferior epigastric perforator (DIEP) flap has become the workhorse flap for autologous breast reconstruction. Despite increased reports on DIEP flaps, umbilical complications have not been previously studied. The aesthetics of the umbilicus dictates the beauty of the abdomen, and it is critical for plastic surgeons to minimize the scarring of the umbilicus. In this study, we retrospectively reviewed patients who underwent DIEP flaps to determine the predictors of umbilical complications, and created a classification system of these wounds...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654573/patterns-of-adjuvant-therapy-utilization-in-uterine-carcinosarcoma-stages-i-to-iii-a-national-cancer-database-analysis
#9
William A Stokes, Tyler P Robin, Matthew W Jackson, Arya Amini, Tracey E Schefter, Carolyn C Lefkowits, Christine M Fisher
OBJECTIVE: The objective of this study is to characterize patterns of utilization of adjuvant chemotherapy (CT) and radiotherapy (RT) in the posthysterectomy management of uterine carcinosarcoma (UCS) in the United States. MATERIALS AND METHODS: We queried the National Cancer Database for women diagnosed with UCS between 2004 and 2012 and undergoing hysterectomy. Logistic regression was performed to identify sociodemographic, facility-specific, and treatment-related predictors of receiving multiagent chemotherapy, external beam radiotherapy (EBRT), or brachytherapy (BT)...
June 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28654355/a-prognostic-scoring-tool-for-cesarean-organ-space-surgical-site-infections-derivation-and-internal-validation
#10
Srisuda Assawapalanggool, Nongyao Kasatpibal, Supatra Sirichotiyakul, Rajin Arora, Watcharin Suntornlimsiri
BACKGROUND: Organ/space surgical site infections (SSIs) are serious complications after cesarean delivery. However, no scoring tool to predict these complications has yet been developed. This study sought to develop and validate a prognostic scoring tool for cesarean organ/space SSIs. METHODS: Data for case and non-case of cesarean organ/space SSI between January 1, 2007 and December 31, 2012 from a tertiary care hospital in Thailand were analyzed. Stepwise multivariable logistic regression was used to select the best predictor combination and their coefficients were transformed to a risk scoring tool...
June 27, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28654289/oxidation-of-natural-bioactive-flavonolignan-2-3-dehydrosilybin-an-electrochemical-and-spectral-study
#11
Romana Sokolova, Jana Kocabova, Petr Marhol, Jan Fiedler, David Biedermann, Jan Vacek, Vladimir Kren
The electrochemical oxidation of the natural antioxidant 2,3-dehydrosilybin (DHS) was investigated in acetonitrile. The spectral changes during two electron and two proton oxidation registered by in situ IR spectroelectrochemistry show that the electron transfer is followed by a subsequent chemical reaction with traces of water. A benzofuranone derivative (BF) is formed by ECEC (electron transfer - chemical reaction - electron transfer - chemical reaction) process at the potential of the first oxidation wave...
June 27, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28653965/factors-influencing-the-underreporting-of-concussion-in-sports-a-qualitative-study-of-minor-hockey-participants
#12
Michael D Cusimano, Jane Topolovec-Vranic, Stanley Zhang, Sarah J Mullen, Mattew Wong, Gabriela Ilie
OBJECTIVE: The present study is to identify factors contributing to underreporting of concussion in adolescent athletes. DESIGN: Qualitative interviews. SETTING: Participants were interviewed in an office environment. PARTICIPANTS: Interviews were conducted with 31 minor hockey players, 10 parents, 6 coaches, 4 trainers, 2 managers, and one game official. Players were 13 to 15 year old. With selective sampling, an inductive approach of analyzing the interviews was undertaken and themes were identified and analyzed...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653850/discovery-and-evaluation-of-anti-fibrinolytic-plasmin-inhibitors-derived-from-5-4-piperidyl-isoxazol-3-ol-4-piol
#13
Thomas Christian Schmidt, Per-Olof Eriksson, David Gustafsson, David Cosgrove, Bente Frolund, Jonas Boström
Inhibition of Plasmin has been found to effectively reduce fibrinolysis and to avoid hemorrhage. This can be achieved by addressing its kringle 1 domain with the known drug, and lysine analogue, tranexamic acid.1 Guided by shape similarities towards a previously discovered lead compound, 5-(4-piperidyl)isoxazol-3-ol, a set of 16 structurally similar compounds was assembled and investigated. Successfully, in vitro measurements revealed one compound, 5-(4-piperidyl)isothiazol-3-ol, superior in potency compared to the initial lead...
June 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28653658/charge-ordering-and-magnetic-frustration-in-csfe2f6
#14
Shanshan Liu, Yuanhui Xu, Yanli Cui, Jing Wang, Keju Sun, Shengxue Yu, Xianfeng Hao
The structural, electronic and magnetic properties of a charge-ordered iron fluoride material CsFe(2+)Fe(3+)F6 have been explored by density functional theory calculations based on the generalized gradient approximation  +  U approach, which was implemented in the VASP code. The material exhibits a 3D pyrochlore-related structure which consists of corner-shared Fe(2+)F6 and Fe(3+)F6 octahedra. Our results confirm that CsFe2F6 is a Mott-Hubbard insulator, and bears a magnetically frustrated ground state in which the localized 3d electrons are antiferromagnetically coupled between the homogeneous Fe ions (Fe(3+)-Fe(3+) along the b axis, and Fe(2+)-Fe(2+) along the a axis), while interactions between the heterogeneous Fe ions (Fe(3+)-Fe(2+) along the c axis) are frustrated, consistent with Goodenough-Kanamori superexchange interactions...
June 27, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28653553/surgical-complications-from-superior-canal-dehiscence-syndrome-repair-two-decades-of-experience
#15
Yanjun Xie, Jeffrey D Sharon, Seth E Pross, Nicholas B Abt, Sanskriti Varma, Charley C Della Santina, Lloyd B Minor, And John P Carey
Objective To determine the incidence of surgical complications associated with superior canal dehiscence syndrome (SCDS) repair and identify the demographic, medical, and intraoperative risk factors that are associated with SCDS complications. Study Design Cases series with chart review, including patients who underwent SCDS repair between 1996 and 2015. Setting A tertiary care academic medical center. Subjects and Methods Data were collected from 220 patients, including demographic information, medical comorbidities, prior otologic surgical history, surgical approach, intraoperative findings, and postoperative complications...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28653440/treatment-of-breast-cancer-related-lymphedema-with-adipose-derived-regenerative-cells-and-fat-grafts-a-feasibility-and-safety-study
#16
Navid Mohamadpour Toyserkani, Charlotte Harken Jensen, Ditte Caroline Andersen, Søren Paludan Sheikh, Jens Ahm Sørensen
Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure...
June 27, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28653405/positive-youth-development-among-diverse-racial-ethnic-children-quality-afterschool-contexts-as-developmental-assets
#17
Emilie Phillips Smith, Dawn P Witherspoon, D Wayne Osgood
Positive youth development (PYD) deserves more empirical attention, particularly among children of diverse racial-ethnic backgrounds. Given the need among families for monitoring and supervision during out-of-school time, community-based afterschool is a potentially promotive ecological setting. This study explores the quality of afterschool experiences upon PYD. This multimethod study includes over 500 elementary school children in Grades 2-5 (Mage  = 8.80, SD = 1.12). The sample comprises of 49% White, 27% African American, 7% Latino, and 17% mixed race/others with 45% free/reduced lunch eligible children...
June 26, 2017: Child Development
https://www.readbyqxmd.com/read/28653261/future-enhanced-clinical-role-of-pharmacists-in-emergency-departments-in-england-multi-site-observational-evaluation
#18
Elizabeth Hughes, David Terry, Chi Huynh, Konstantinos Petridis, Matthew Aiello, Louis Mazard, Hirminder Ubhi, Alex Terry, Keith Wilson, Anthony Sinclair
Background There are concerns about maintaining appropriate clinical staffing levels in Emergency Departments. Pharmacists may be one possible solution. Objective To determine if Emergency Department attendees could be clinically managed by pharmacists with or without advanced clinical practice training. Setting Prospective 49 site cross-sectional observational study of patients attending Emergency Departments in England. Method Pharmacist data collectors identified patient attendance at their Emergency Department, recorded anonymized details of 400 cases and categorized each into one of four possible options: cases which could be managed by a community pharmacist; could be managed by a hospital pharmacist independent prescriber; could be managed by a hospital pharmacist independent prescriber with additional clinical training; or medical team only (unsuitable for pharmacists to manage)...
June 26, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28653187/virus-host-gene-interactions-define-hiv-1-disease-progression
#19
Daniela C Monaco, Zachary Ende, Eric Hunter
In this chapter, we will review recent research on the virology of HIV-1 transmission and the impact of the transmitted virus genotype on subsequent disease progression. In most instances of HIV-1 sexual transmission, a single genetic variant, or a very limited number of variants from the diverse viral quasi-species present in the transmitting partner establishes systemic infection. Transmission involves both stochastic and selective processes, such that in general a minority variant in the donor is transmitted...
June 27, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28653120/automation-of-radiation-treatment-planning-evaluation-of-head-and-neck-cancer-patient-plans-created-by-the-pinnacle-3-scripting-and-auto-planning-functions
#20
Stefan Speer, Andreas Klein, Lukas Kober, Alexander Weiss, Indra Yohannes, Christoph Bert
BACKGROUND: Intensity-modulated radiotherapy (IMRT) techniques are now standard practice. IMRT or volumetric-modulated arc therapy (VMAT) allow treatment of the tumor while simultaneously sparing organs at risk. Nevertheless, treatment plan quality still depends on the physicist's individual skills, experiences, and personal preferences. It would therefore be advantageous to automate the planning process. This possibility is offered by the Pinnacle(3) treatment planning system (Philips Healthcare, Hamburg, Germany) via its scripting language or Auto-Planning (AP) module...
June 26, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
keyword
keyword
1236
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"