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https://www.readbyqxmd.com/read/29786737/anti-amyloidogenic-properties-of-an-ethyl-acetate-fraction-from-actinidia-arguta-in-a%C3%AE-1-42-induced-icr-mice
#1
Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin Heo
This study aimed to investigate the ameliorating effect of an ethyl acetate fraction from the fruit Actinidia arguta (EFAA) on amyloid beta (Aβ)-induced neurotoxicity and cognitive deficits in ICR mice. EFAA showed potent protective effects against Aβ-induced neurotoxicity through 2',7'-dichlorofluorescein diacetate (DCF-DA), 2',3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release into the assay medium. EFAA treatment reduced the intracellular ROS level and lactate dehydrogenase (LDH) release in the mitochondria, and increased cell viability in Aβ-induced neuroblastoma MC-IXC cells...
May 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29785574/in-situ-nanostructured-hydrogel-of-resveratrol-for-brain-targeting-in-vitro-in-vivo-characterization
#2
Amarjitsing Rajput, Aditi Bariya, Ahmed Allam, Sarah Othman, Shital B Butani
The purpose of conducting the present research work was to develop resveratrol nanostructured in situ gel for the treatment of Alzheimer's disease. Resveratrol loaded lipid carrier was prepared by melt emulsification-probe sonication method, and the final product was evaluated for particle size (132 ± 11.90 nm), polydispersity index (0.209 ± 0.005), zeta potential (- 23 ± 3.79 mV), drug loading (9.26 ± 3.79%), and entrapment efficiency (74 ± 11.40%). Following incorporation of the resveratrol nanostructured lipid carrier in gellan gum and xanthan gum, in situ gel was formulated and characterized...
May 21, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29784726/teaching-neuroimages-convexal-subarachnoid-hemorrhage-accompanied-by-transient-global-amnesia
#3
Markus Beitzke, Christian Enzinger, Franz Fazekas
No abstract text is available yet for this article.
May 22, 2018: Neurology
https://www.readbyqxmd.com/read/29784659/united-states-of-amnesia-rescuing-memory-loss-from-diverse-conditions
#4
EDITORIAL
Clara Ortega-de San Luis, Tomás J Ryan
Amnesia - the loss of memory function - is often the earliest and most persistent symptom of dementia. It occurs as a consequence of a variety of diseases and injuries. These include neurodegenerative, neurological or immune disorders, drug abuse, stroke or head injuries. It has both troubled and fascinated humanity. Philosophers, scientists, physicians and anatomists have all pursued an understanding of how we learn and memorise, and why we forget. In the last few years, the development of memory engram labelling technology has greatly impacted how we can experimentally study memory and its disorders in animals...
May 18, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29775775/knowledge-and-learning-of-verb-biases-in-amnesia
#5
Rachel Ryskin, Zhenghan Qi, Natalie V Covington, Melissa Duff, Sarah Brown-Schmidt
Verb bias-the co-occurrence frequencies between a verb and the syntactic structures it may appear with-is a critical and reliable linguistic cue for online sentence processing. In particular, listeners use this information to disambiguate sentences with multiple potential syntactic parses (e.g., Feel the frog with the feather.). Further, listeners dynamically update their representations of specific verbs in the face of new evidence about verb-structure co-occurrence. Yet, little is known about the biological memory systems that support the use and dynamic updating of verb bias...
May 15, 2018: Brain and Language
https://www.readbyqxmd.com/read/29775673/gender-dependent-contribution-of-muscarinic-receptors-in-memory-retrieval-under-sub-chronic-stress
#6
Habiba Rashid, Touqeer Ahmed
Stress induces retrograde amnesia in humans and rodents. Muscarinic antagonism under normal physiological conditions causes gender dependent impairment in episodic memory retrieval. We aimed to explore the gender dependent role of muscarinic receptors in memory retrieval under sub-chronic stress condition. Male and female mice were trained for Morris water maze test and contextual fear conditioning, followed by 3 hour restraint stress per day for five days. Stress was either given alone or in combination with a daily subcutaneous injection of scopolamine (1 mg/kg) or donepezil (1 mg/kg)...
May 15, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29774783/connecting-the-dots-an-association-between-opioids-and-acute-hippocampal-injury
#7
Jed A Barash, W Andrew Kofke
Acute hippocampal injury represents a relatively rare cause of amnesia. Interestingly however, between 2012 and 2017, 18 patients were reported at hospitals in Massachusetts with sudden-onset amnesia in the setting of complete diffusion-weighted hyperintensity of both hippocampi on magnetic resonance imaging. Notably, 17 of the 18 patients tested positive for opioids or had a recorded history of opioid use. This observation suggests an association between opioids and acute hippocampal injury. With particular attention to the Massachusetts cluster and data on fentanyl and its congeners, the epidemiological and pathophysiological evidence that supports this hypothesis is presented, as are potential underlying mechanisms...
May 18, 2018: Neurocase
https://www.readbyqxmd.com/read/29773221/are-there-distinct-forms-of-accelerated-forgetting-and-if-so-why
#8
Andrew R Mayes, Nicola M Hunkin, Claire Isaac, Nils Muhlert
Whether accelerated long-term forgetting (ALF) and classic organic amnesia, particularly hippocampal-amnesia, differ qualitatively or merely quantitatively is disputed. Qualitative difference accounts postulate that ALF patients show normal recall memory for at least minutes, during which hippocampal-amnesics already show accelerated forgetting and impaired recall but, thereafter, ALF patients show accelerated forgetting and impaired delayed recall. These delayed impairments may be more severe than those shown by hippocampal-amnesics...
April 19, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29770155/neuroprotective-effect-and-molecular-mechanism-of-6-gingerol-against-scopolamine-induced-amnesia-in-c57bl-6-mice
#9
Chang-Yul Kim, Yongtaek Seo, Chan Lee, Gyu Hwan Park, Jung-Hee Jang
We have investigated the neuroprotective and memory enhancing effect of [6]-gingerol (GIN), a pungent ingredient of ginger, using an animal model of amnesia. To determine the neuroprotective effect of GIN on cognitive dysfunction, scopolamine (SCO, 1 mg/kg, i.p.) was injected into C57BL/6 mice, and a series of behavioral tests were conducted. SCO-induced behavior changes and memory impairments, such as decreased alteration (%) in Y-maze test, increased mean escape latency in water maze test, diminished step-through latency in passive avoidance test, and shortened freezing time in fear condition test, were significantly prevented and restored by the oral administration of GIN (10 or 25 mg/kg/day)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29767374/the-effect-of-ca1-dopaminergic-system-on-amnesia-induced-by-harmane-in-mice
#10
Mohammad Nasehi, Simin Hasanvand, Fatemeh Khakpai, Mohammad-Reza Zarrindast
In the present study, the effects of bilateral injections of dopaminergic drugs into the hippocampal CA1 regions (intra-CA1) on harmane-induced amnesia were examined in mice. We used a single-trial step-down inhibitory avoidance task for the assessment of memory acquisition in adult male mice. Our data indicated that pre-training intra-peritoneal (i.p.) administration of harmane (12 mg/kg) impaired memory acquisition. Moreover, intra-CA1 administration of dopamine D1 receptor agonist, SKF38393 (0.25 µg/mouse), dopamine D1 receptor antagonist, SCH23390 (0...
May 16, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29760675/feigning-amnesia-moderately-impairs-memory-for-a-mock-crime-video
#11
Ivan Mangiulli, Kim van Oorsouw, Antonietta Curci, Harald Merckelbach, Marko Jelicic
Previous studies showed that feigning amnesia for a crime impairs actual memory for the target event. Lack of rehearsal has been proposed as an explanation for this memory-undermining effect of feigning. The aim of the present study was to replicate and extend previous research adopting a mock crime video instead of a narrative story. We showed participants a video of a violent crime. Next, they were requested to imagine that they had committed this offense and to either feign amnesia or confess the crime. A third condition was included: Participants in the delayed test-only control condition did not receive any instruction...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29754157/-patient-satisfaction-with-procedural-sedation-in-oral-and-maxillofacial-surgery
#12
J T Deferm, M Burger, T Prudon, M van Bergen, M Vaneker, W A Borstlap
Fear of treatment by an oral and maxillofacial (OMF) surgeon or the dentist is a widespread and deep-rooted phenomenon. A patient can be taught to cope with dental phobia by means of psychological, cognitive behavioural therapy, but in cases of invasive oral treatment, such therapy may be insufficiently effective. For these invasive procedures, sedation serves as an alternative treatment option. The department of Oral and Maxillofacial Surgery at the Radboud University Medical Centre in Nijmegen, the Netherlands, offers the possibility to utilise intravenous sedation with midazolam (Dormicum®) and remifentanil (Ultiva®)...
May 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29742814/optogenetic-stimulation-understanding-memory-and-treating-deficits
#13
S C Barnett, B A L Perry, J C Dalrymple-Alford, L C Parr-Brownlie
Technology allowing genetically targeted cells to be modulated by light has revolutionised neuroscience in the past decade, and given rise to the field of optogenetic stimulation. For this, non-native, light activated proteins (e.g. channelrhodopsin) are expressed in a specific cell phenotype (e.g. glutamatergic neurons) in a subset of central nervous system nuclei, and short pulses of light of a narrow wavelength (e.g. blue, 473 nm) are used to modulate cell activity. Cell activity can be increased or decreased depending on which light activated protein is used...
May 9, 2018: Hippocampus
https://www.readbyqxmd.com/read/29740317/-moringa-oleifera-seed-extract-alleviates-scopolamine-induced-learning-and-memory-impairment-in-mice
#14
Juan Zhou, Wu-Shuang Yang, Da-Qin Suo, Ying Li, Lu Peng, Lan-Xi Xu, Kai-Yue Zeng, Tong Ren, Ying Wang, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Jin
The extract of Moringa oleifera seeds has been shown to possess various pharmacological properties. In the present study, we assessed the neuropharmacological effects of 70% ethanolic M. oleifera seed extract (MSE) on cognitive impairment caused by scopolamine injection in mice using the passive avoidance and Morris water maze (MWM) tests. MSE (250 or 500 mg/kg) was administered to mice by oral gavage for 7 or 14 days, and cognitive impairment was induced by intraperitoneal injection of scopolamine (4 mg/kg) for 1 or 6 days...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29739129/evaluation-of-relationship-between-obsessive-compulsive-disorder-and-dissociative-experiences
#15
Mustafa Tatlı, Ozlem Cetinkaya, Fulya Maner
Objective: The aim of the study is to evaluate the relationship between obsessive-compulsive disorder (OCD) symptoms and dissociative experiences and the effect of childhood traumatic experiences on this relationship in OCD patients. Methods: Fifty consecutive OCD patients and 50 healthy controls are enrolled for this study. Sociodemographic and Clinical Data Form, Dissociative Experiences Scale (DES), Padua Inventory (PI) and Childhood Trauma Questionnaire (CTQ) are applied to participants...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29735495/anaesthetic-management-of-a-patient-with-a-unique-combination-of-anti-n-methyl-d-aspartate-receptor-encephalitis-and-stiff-person-syndrome
#16
Mohammad Hadi Gharedaghi, Arjang Khorasani, Nebojsa Nick Knezevic, Farzad Ebrahimi
Stiff-person syndrome (SPS) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis are rare paraneoplastic syndromes caused by antibodies that target the central nervous system. Here, we describe a 26-year-old woman who presented with psychosis, amnesia, rigidity and fever. After extensive diagnostic and laboratory workup, she was diagnosed with an ovarian teratoma which was causing the symptoms of anti-NMDAR encephalitis and SPS. The patient was successfully treated with laparoscopic removal of the ovarian tumour under general anaesthesia...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29730271/intraventricular-extension-of-an-aneurysmal-subarachnoid-hemorrhage-is-an-independent-predictor-of-a-worse-functional-outcome
#17
Mario Zanaty, Daichi Nakagawa, Robert M Starke, Enrique C Leira, Edgar A Samaniego, Waldo R Guerrero, James Torner, Yasunori Nagahama, Olatilewa Awe, Jeremy Greenlee, Joseph S Hudson, Lauren Allan, Reem Elwy, Nohra Chalouhi, Pascal Jabbour, Royce Woodroffe, Anthony Piscopo, David Hasan
OBJECTIVE: The objective of this study is to determine the impact of intraventricular hemorrhage (IVH) on the cognitive prognosis of subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm, independent of the presence of intraparenchymal hemorrhage, hydrocephalus or vasospasm. PATIENT AND METHODS: A Retrospective review of a prospectively collected database of patients with aneurysmal SAH from July 2009 to November 2016 was performed. Patients were included if they had a saccular aneurysm with a Hunt-Hess grade (HHG) 1-3...
April 30, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29720346/tako-tsubo-cardiomyopathy-with-transient-global-amnesia-and-cerebellar-embolic-stroke-triggered-by-existential-fear
#18
Claudia Stöllberger, Nicolas DeCillia, Josef Finsterer
BACKGROUND: Embolic stroke is a complication of Tako-Tsubo-cardiomyopathy (TTC), transient left ventricular dysfunction mimicking myocardial infarction without coronary culprit lesion explaining the whole left ventricular dysfunction. Transient global amnesia (TGA) is characterized by sudden onset of anterograde amnesia without compromise of other neurologic functions. CASE REPORT: A 57 years old female was admitted because of sudden confusion and loss of her memory after emotional stress...
January 6, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29716575/terminalia-chebula-extract-prevents-scopolamine-induced-amnesia-via-cholinergic-modulation-and-anti-oxidative-effects-in-mice
#19
Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han, Won Kyung Jeon
BACKGROUND: Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of T. chebula has not yet been investigated. The present study was designed to determine whether T. chebula extract (TCE) alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with cholinergic system and anti-oxidant effects...
May 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29715544/semantic-memory-in-developmental-amnesia
#20
REVIEW
Rachael L Elward, Faraneh Vargha-Khadem
Patients with developmental amnesia resulting from bilateral hippocampal atrophy associated with neonatal hypoxia-ischaemia typically show relatively preserved semantic memory and factual knowledge about the natural world despite severe impairments in episodic memory. Understanding the neural and mnemonic processes that enable this context-free semantic knowledge to be acquired throughout development without the support of the contextualised episodic memory system is a serious challenge. This review describes the clinical presentation of patients with developmental amnesia, contrasts its features with those reported for adult-onset hippocampal amnesia, and analyses the effects of variables that influence the learning of new semantic information...
April 28, 2018: Neuroscience Letters
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