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https://www.readbyqxmd.com/read/28646347/alendronate-treatment-induces-il-1b-expression-and-apoptosis-in-glioblastoma-cell-line
#1
Paola Maura Tricarico, Angeladine Epate, Fulvio Celsi, Sergio Crovella
Alendronate (ALD), one among the nitrogen-containing bisphosphonates (NBPs), is currently used for the treatment of many pathological conditions. Unfortunately, although generally tolerated, NBPs treatment has been associated with central nervous system (CNS) adverse outcomes, such as amnesia, hallucinations and visual disturbances. So, we analyzed the effect of ALD treatment in glial cells, the main sources of cholesterol for neurons and principal cells involved in the immunological defense of the brain. We treated a glial cell line (U87-MG) with increasing doses of ALD (0...
June 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28644249/incidental-hippocampal-hyperintensity-on-diffusion-weighted-mri-individual-susceptibility-to-transient-global-amnesia
#2
Moonyoung Jeong, Jaehyun Jin, Jeong Hee Kim, Yeonsil Moon, Jin Woo Choi, Hahn Young Kim
OBJECTIVES: Dot-like hippocampal hyperintensities (HHs) on diffusion-weighted MRI (DWI) have been reported as an interesting imaging finding of transient global amnesia (TGA) that is characterized by typical anterograde amnesia. However, we found that these dot-like HHs are occasionally seen in some patients without clinical symptoms of TGA. METHODS: We identified 8 patients who did not show clinical symptoms of TGA, despite the presence of hippocampal lesions on DWI (No-TGA group, n=8)...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28629646/memory-and-time-backward-and-forward-telescoping-in-alzheimer-s-disease
#3
Mohamad El Haj, Steve M J Janssen, Pascal Antoine
Backward and forward telescoping are opposite timing biases. The former refers to misattributing events to earlier dates, whereas the latter refers to misattributing events to later dates. The present study investigated both biases in participants with Alzheimer's Disease (AD) and healthy older adults, matched on age, sex, and education level. Participants were asked to recall the years when five remote and five recent public events had occurred. They were also assessed with a cognitive and clinical battery that included a context memory task on which they had to associate letters and locations...
June 16, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28626484/cognitive-enhancing-of-pineapple-extract-and-juice-in-scopolamine-induced-amnesia-in-mice
#4
Amir Abbas Momtazi-Borojeni, Hojjat Sadeghi-Aliabadi, Mohammed Rabbani, Alireza Ghannadi, Elham Abdollahi
The objective of the present study was to evaluate the cognitive enhancing of pineapple juice and ethanolic extract in scopolamine-induced cognitive deficit mice. The ethanolic extract of pineapple (Ananas comosus (L.) Merr.) was prepared by maceration method and its juice was obtained by a homogenizer. Object recognition task was used to evaluate the mice memory. Exploration time in the first and second trial was recorded. The differences in exploration time between a familiar and a novel object in the second trial were taken as a memory index...
June 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28626186/reversible-cerebral-vasoconstriction-syndrome-presenting-with-transient-global-amnesia
#5
Kenji Isahaya, Kensuke Shinohara, Masashi Akamatu, Takahiro Shimizu, Kenzo Sakurai, Makoto Shiraishi, Hisanao Akiyama, Yasuhiro Hasegawa
A 65-year-old man who had been diagnosed with transient global amnesia (TGA) 15 years previously was admitted to hospital with complaints of amnesia and headache. His symptoms improved on day-2. The initial brain MRI and electroencephalography findings were normal. He was diagnosed with a recurrence of TGA and discharged. However, he returned with right leg weakness and complained of a thunderclap headache. MRI demonstrated subarachnoid hemorrhage and multifocal segmental narrowing of the left posterior cerebral artery (PCA) and large intracranial arteries, and he was diagnosed with reversible cerebral vasoconstriction syndrome (RCVS)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28625659/abnormal-semantic-knowledge-in-a-case-of-developmental-amnesia
#6
Anna Blumenthal, Devin Duke, Ben Bowles, Asaf Gilboa, R Shayna Rosenbaum, Stefan Köhler, Ken McRae
An important theory holds that semantic knowledge can develop independently of episodic memory. One strong source of evidence supporting this independence comes from the observation that individuals with early hippocampal damage leading to developmental amnesia generally perform normally on standard tests of semantic memory, despite their profound impairment in episodic memory. However, one aspect of semantic memory that has not been explored is conceptual structure. We built on the theoretically important distinction between intrinsic features of object concepts (e...
June 15, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28620339/the-stress-acceleration-hypothesis-of-nightmares
#7
Tore Nielsen
Adverse childhood experiences can deleteriously affect future physical and mental health, increasing risk for many illnesses, including psychiatric problems, sleep disorders, and, according to the present hypothesis, idiopathic nightmares. Much like post-traumatic nightmares, which are triggered by trauma and lead to recurrent emotional dreaming about the trauma, idiopathic nightmares are hypothesized to originate in early adverse experiences that lead in later life to the expression of early memories and emotions in dream content...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28619854/dissociation-defining-the-concept-in-criminal-forensic-psychiatry
#8
Dominique Bourget, Pierre Gagné, Stephen Floyd Wood
Claims of amnesia and dissociative experiences in association with a violent crime are not uncommon. Research has shown that dissociation is a risk factor for violence and is seen most often in crimes of extreme violence. The subject matter is most relevant to forensic psychiatry. Peritraumatic dissociation for instance, with or without a history of dissociative disorder, is quite frequently reported by offenders presenting for a forensic psychiatric examination. Dissociation or dissociative amnesia for serious offenses can have legal repercussions stemming from their relevance to the legal constructs of fitness to stand trial, criminal responsibility, and diminished capacity...
June 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/28619233/do-we-have-distinct-systems-for-immediate-and-delayed-actions-a-selective-review-on-the-role-of-visual-memory-in-action
#9
REVIEW
Thomas Schenk, Constanze Hesse
The perception-action model with its assumptions of distinct visual pathways for perception and visuomotor control has been highly influential but also contentious. The controversy largely focused on the evidence from studies on perceptual illusions and this scientific field has been reviewed quite a few times in recent years. In contrast another aspect of the model, namely the role of visual memory in action control, received comparatively little attention. With respect to visual memory the perception-action model proposes that only the perceptual or ventral stream can maintain a sustained representation of the visual world while the visuomotor system or dorsal stream has to rely on currently available visual information...
May 25, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28618650/anti-amnesic-effects-of-ganoderma-species-a-possible-cholinergic-and-antioxidant-mechanism
#10
Ravneet Kaur, Varinder Singh, Richa Shri
Mushrooms are valued for their nutritional as well as medicinal properties. Ganoderma species are used traditionally to treat neurological disorders but scientific evidence for this is insufficient. The present study was designed to systematically evaluate the anti-amnesic effect of selected Ganoderma species i.e. G. mediosinense and G. ramosissimum. Extracts of selected mushroom species were evaluated for their antioxidant activity and acetylcholinesterase (AChE) inhibition using in-vitro assays (DPPH and Ellman tests respectively)...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28615475/infantile-amnesia-a-critical-period-of-learning-to-learn-and-remember
#11
Cristina M Alberini, Alessio Travaglia
Infantile amnesia, the inability of adults to recollect early episodic memories, is associated with the rapid forgetting that occurs in childhood. It has been suggested that infantile amnesia is due to the underdevelopment of the infant brain, which would preclude memory consolidation, or to deficits in memory retrieval. Although early memories are inaccessible to adults, early-life events, such as neglect or aversive experiences, can greatly impact adult behavior and may predispose individuals to various psychopathologies...
June 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28611653/familial-retinal-arteriolar-tortuosity-with-acute-hippocampal-infarction
#12
Tae Hee Kim, Sonia Lee, Su Jin Lim
PURPOSE: To report a case of familial retinal arteriolar tortuosity with acute hippocampal infarction. METHOD: Single-patient case report. RESULTS: A 50-year-old woman presented with blurred vision and was found to have cataract, retinal hemorrhages, and tortuous retinal arterioles in both eyes. Similar findings of tortuous retinal arterioles were observed in her daughter and son. In her past history of 6 years prior to the visit, she had been diagnosed with transient global amnesia after brain magnetic resonance imaging, which showed hippocampal infarction and multiple chronic ischemic lesions in the periventricular and subcortical white matter...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28611087/acute-ischemic-stroke-after-moderate-to-severe-traumatic-brain-injury-incidence-and-impact-on-outcome
#13
Robert G Kowalski, Juliet K Haarbauer-Krupa, Jeneita M Bell, John D Corrigan, Flora M Hammond, Michel T Torbey, Melissa C Hofmann, Kristen Dams-O'Connor, A Cate Miller, Gale G Whiteneck
BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) leads to nearly 300 000 annual US hospitalizations and increased lifetime risk of acute ischemic stroke (AIS). Occurrence of AIS immediately after TBI has not been well characterized. We evaluated AIS acutely after TBI and its impact on outcome. METHODS: A prospective database of moderate to severe TBI survivors, admitted to inpatient rehabilitation at 22 Traumatic Brain Injury Model Systems centers and their referring acute-care hospitals, was analyzed...
June 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28609804/psychometric-properties-of-brief-screening-tests-for-alcohol-use-disorders-during-pregnancy-in-argentina
#14
Mariana Beatriz López, Aldana Lichtenberger, Karina Conde, Mariana Cremonte
Background Considering the physical, mental and behavioral problems related to fetal alcohol exposure, prenatal clinical guides suggest a brief evaluation of alcohol consumption during pregnancy to detect alcohol intake and to adjust interventions, if required. Even if any alcohol use should be considered risky during pregnancy, identifying women with alcohol use disorders is important because they could need a more specific intervention than simple advice to abstain. Most screening tests have been developed and validated in male populations and focused on the long-term consequences of heavy alcohol use, so they might be inappropriate to assess consumption in pregnant women...
June 13, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28601130/neurobehavioral-management-of-traumatic-brain-injury-in-the-critical-care-setting-an-update
#15
REVIEW
Earl De Guzman, Andrea Ament
Traumatic brain injury (TBI) is an alteration in brain function, or other evidence of brain pathology, caused by an external force. TBI is a major cause of disability and mortality worldwide. Post-traumatic amnesia, or the interval from injury until the patient is oriented and able to form and later recall new memories, is an important index of TBI severity and functional outcome. This article will discuss the updates in the epidemiology, definition and classification, pathophysiology, diagnosis, and management of common acute neuropsychiatric sequelae of traumatic brain injury that the critical care specialist may encounter...
July 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/28598840/neuropsychological-symptoms-in-sporadic-creutzfeldt-jakob-disease-patients-in-germany
#16
Anna Krasnianski, Geeske T Bohling, Uta Heinemann, Daniela Varges, Bettina Meissner, Walter J Schulz-Schaeffer, Andreas Reif, Inga Zerr
BACKGROUND: The polymorphism at codon 129 of the prion protein gene (PRNP) and the PrPSc types 1 and 2 belong to a molecular classification of sporadic Creutzfeldt-Jakob disease (sCJD) that correlates well with the clinical and neuropathological phenotype of sCJD. OBJECTIVE: The aim of the study was to perform the first detailed evaluation of neuropsychological deficits in a large group of definite sCJD patients with known molecular subtype. METHODS: We analyzed neuropsychological symptoms in a cohort of 248 sCJD patients with known M129 V polymorphism of PRNP and prion protein type...
June 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28597920/a-case-of-nonfatal-intoxication-associated-with-the-recreational-use-of-diphenidine
#17
Enrico Gerace, Elena Bovetto, Daniele Di Corcia, Marco Vincenti, Alberto Salomone
Diphenidine is a dissociative drug that shows several psychotropic effects including euphoria, shifts in perception of reality, hallucinations, and transient anterograde amnesia. In this study, a case of acute intoxication occurring after diphenidine intake is reported. A 30-year-old Caucasian male was hospitalized after he was found in a confused and agitated state and unable to communicate. The physical examination displayed tachycardia, miotic pupils, and increased both body temperature and respiratory rate...
June 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28596462/-pure-amnesia
#18
Koichi Tagawa, Haruki Tokida
Pure amnesia (amnesic syndrome) is an organic brain syndrome characterized by impairment in episodic memory, with either an anterograde or sometimes retrograde loss of memories. Although episodic memory is impaired, semantic memory, immediate memory, and procedural memory are preserved. The Papez circuit is a network of nerve fibers and nerve centers that starts and ends in the hippocampus travelling by way of the fornix, mammillary bodies, anterior thalamic nuclei, cingulate gyrus, and parahippocampal gyrus...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28591393/the-relationship-between-the-first-world-war-and-neurology-100-years-of-shell-shock
#19
José Luiz Pedroso, Stefanie C Linden, Orlando G Barsottini, Péricles Maranhão, Andrew J Lees
The First World War was a global war, beginning on 28 July 1914, until 11 November 1918. Soon after the beginning of the war, there was an "epidemic" of neurological conversion symptoms. Soldiers on both sides started to present in large numbers with neurological symptoms, such as dizziness, tremor, paraplegia, tinnitus, amnesia, weakness, headache and mutism of psychosomatic origin. This condition was known as shell shock, or "war neurosis". Because medically unexplained symptoms remain a major challenge, and considering the close relationship of symptoms described in shell shock with clinical neurology, we should study their history in order to improve future care...
May 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28587365/assessment-of-different-loading-doses-of-dexmedetomidine-hydrochloride-in-preventing-adverse-reaction-after-combined-spinal-epidural-anesthesia
#20
Wanwei Jiang, Qinghui Wang, Min Xu, Yu Li, Rui Yang, Xiaoyang Song, Haixia Duan, Pengbo Zhang
We conducted the present study to investigate the effects of the different loading doses of dexmedetomidine hydrochloride in the prevention of adverse reactions after combined spinal-epidural anesthesia. A total of 200 patients that were admitted to the Department of Obstetrics at the Second Affiliated Hospital of Xi'an Jiaotong University hospital and treated with cesarean section through the use of combined spinal-epidural anesthesia from December, 2014 to June, 2016, were randomly divided into 4 groups. The therapeutic regimens of patients were shown as follows: group A was administered an intravenous pump of 10 ml/l physiological saline in surgery until the end of the delivery...
June 2017: Experimental and Therapeutic Medicine
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