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https://www.readbyqxmd.com/read/28746781/human-herpesvirus-6-encephalitis-following-chemotherapy-induction-for-acute-myelogenous-leukemia
#1
John W Frey, Joseph N Cherabie, Maha A Assi
We report a case of human herpesvirus-6 (HHV-6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad-spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Electroencephalogram and magnetic resonance imaging of the brain were unremarkable. Following diagnosis, the patient was successfully treated with ganciclovir...
July 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28745847/transient-global-amnesia-emergency-department-evaluation-and-management-digest
#2
Jeremy Samuel Faust, Andreea Nemes, Milana Zaurova
Transient global amnesia is a clinically distinct syndrome characterized by the acute inability to form new memories. It can last up to 24 hours. The diagnosis is dependent on eliminating other more serious etiologies including toxic ingestions, acute strokes, complex partial seizures, and central nervous system infections. Transient global amnesia confers no known long-term risks; however, when abnormal signs or symptoms are present, they take precedence and guide the formulation of a differential diagnosis and investigation...
August 22, 2016: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28735696/the-network-structure-of-posttraumatic-stress-symptoms-in-children-and-adolescents-exposed-to-disasters
#3
Justin D Russell, Erin L Neill, Victor G Carrión, Carl F Weems
OBJECTIVE: To evaluate current theoretical assumptions about the nature of pediatric posttraumatic stress disorder (PTSD) by examining the network structure of PTSD in a sample of youth exposed to disasters and testing for age differences. Network analysis provides the opportunity to identify "central" symptoms that might hold an outsized influence over others and are important targets for research and treatment. The authors hypothesized that particular symptoms would exhibit greater influence over others...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28724260/pleuropterus-multiflorus-hasuo-mediated-straightforward-eco-friendly-synthesis-of-silver-gold-nanoparticles-and-evaluation-of-their-anti-cancer-activity-on-a549-lung-cancer-cell-line
#4
Verónica Castro-Aceituno, Ragavendran Abbai, Seong Soo Moon, Sungeun Ahn, Ramya Mathiyalagan, Yu-Jin Kim, Yeon-Ju Kim, Deok Chun Yang
Pleuropterus multiflorus (Hasuo) is a widely used medicinal plant in Korea and China for treating amnesia, isnomia, heart throbbing etc. With the constructive idea of promoting the wide-spread usage of P. multiflorus, we propose its indirect usage in the form of biologically active silver (Pm-AgNPs) and gold nanoparticles (Pm-AuNPs). The synthesized nanoparticles were predominantly spherical, crystalline with the Z-average hydrodynamic diameter of 274.8nm and 104.8nm respectively. Also, proteins and phenols were identified as the major players involved in their synthesis and stability...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28721685/breaking-down-unitization-is-the-whole-greater-than-the-sum-of-its-parts
#5
Maria C D'Angelo, Alix Noly-Gandon, Arber Kacollja, Morgan D Barense, Jennifer D Ryan
Memory impairments are often observed in aging. Specifically, older adults have difficulty binding together disparate elements (relational memory). We have recently shown that a cognitive strategy known as unitization can mitigate impaired relational learning in the transverse patterning task (TP) in both amnesia and healthy aging. This strategy allows items to be fused together through an interaction such that one item acts upon another. In the context of TP, unitization is comprised of three component processes: (1) fusion, (2) motion, and (3) semantic comprehension of action/consequence sequences...
July 18, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28716085/the-protective-effect-of-fermented-curcuma-longa-l-on-memory-dysfunction-in-oxidative-stress-induced-c6-gliomal-cells-proinflammatory-activated-bv2-microglial-cells-and-scopolamine-induced-amnesia-model-in-mice
#6
Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee, Seun-Ah Yang
BACKGROUND: Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented C. longa (FCL) has not been reported. Therefore, in this study, the effectiveness of FCL for the regulation of memory dysfunction was investigated in two brain cell lines (rat glioma C6 and murine microglia BV2) and scopolamine-treated mice. METHODS: C. longa powder was fermented by 5% Lactobacillus plantarum K154 containing 2% (w/v) yeast extract at 30 °C for 72 h followed by sterilization at 121 °C for 15 min...
July 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28713618/vanillin-and-4-hydroxybenzyl-alcohol-attenuate-cognitive-impairment-and-the-reduction-of-cell-proliferation-and-neuroblast-differentiation-in-the-dentate-gyrus-in-a-mouse-model-of-scopolamine-induced-amnesia
#7
Yang Hee Kim, Joon Ha Park
4-Hydroxy-3-methoxybenzaldehyde (vanillin) and 4-hydroxybenzyl alcohol (4-HBA) are natural phenolic compounds, which present in many plants and have diverse biological properties. In this study, we examined effects of vanillin and 4-HBA on learning and memory function, cell proliferation, and neuroblast differentiation in the hippocampal dentate gyrus in a mouse model of scopolamine-induced amnesia. Scopolamine (SCO; 1 mg/kg/day, intraperitoneally), vanillin, and 4-HBA (40 mg/kg/day, orally) were administered for 28 days...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28711591/touching-the-void-first-and-third-person-perspectives-in-two-cases-of-autobiographical-amnesia-linked-to-temporal-lobe-epilepsy
#8
Adam Zeman, Marcus Byruck, Peter Tallis, Keith Vossel, Daniel Tranel
Temporal lobe epilepsy (TLE) can be associated with a marked impairment of autobiographical memory. This is occasionally its presenting feature. We describe two individuals with severe epilepsy-associated autobiographical memory loss. Both MB and PT were reassured initially that their memory was intact on the basis of standard neuropsychological tests. Both have written detailed accounts of their symptoms. The key neuropsychological features of their cases are the relative normality of performance on standard memory tests, with preservation of semantic memory for impersonal information, in contrast to a profound amnesia for salient autobiographical episodes and an impoverishment of imaginative scene construction...
July 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28711308/the-impact-of-scopolamine-pretreatment-on-3-iodothyronamine-t1am-effects-on-memory-and-pain-in-mice
#9
Annunziatina Laurino, Ersilia Lucenteforte, Gaetano De Siena, Laura Raimondi
We previously demonstrated that 3-iodothyronamine (T1AM), a by-product of thyroid hormone metabolism, pharmacologically administered to mice acutely stimulated learning and memory acquisition and provided hyperalgesia with a mechanism which remains to be defined. We now aimed to investigate whether the T1AM effect on memory and pain was maintained in mice pre-treated with scopolamine, a non-selective muscarinic antagonist expected to induce amnesia and, possibly, hyperalgesia. Mice were pre-treated with scopolamine and, after 20min, injected intracerebroventricularly (i...
July 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28710234/takotsubo-cardiomyopathy-and-transient-global-amnesia-a-shared-aetiology
#10
Jithin Sajeev, Anoop Koshy, Kevin Rajakariar, Gary Gordon
Takotsubo cardiomyopathy (TTC) is associated with acute, reversible left ventricular (LV) dysfunction, while transient global amnesia (TGA) is a reversible disorder of the brain characterised by anterograde amnesia. We report an unusual case of TTC occurring concurrently in a patient with TGA, and propose that catecholamine surge induced cerebral venous congestion and cardiotoxicity is the shared aetiology that leads to the concurrent manifestation of these conditions. TTC and TGA are reversible disorders that can occur concurrently in a subset of patients due to a unifying aetiology, catecholamine excess, leading to pathophysiological changes within the brain and the myocardium...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28706566/motor-vehicle-collisions-caused-by-the-super-strength-synthetic-cannabinoids-mam-2201-5f-pb-22-5f-ab-pinaca-5f-amb-and-5f-adb-in-japan-experienced-from-2012-to-2014
#11
REVIEW
Shuji Kaneko
From 2012 to 2014 in Japan, 214 cases of motor vehicle collisions were attributed to the use of illegal drugs. In 93 out of 96 investigated cases, the causative agents were a variety of synthetic cannabinoids (SCs). These SCs can be classified into three groups according to the lineage of the chemical structures: (1) naphthoyl indoles, such as MAM-2201, (2) quinolinyl ester indoles, such as 5F-PB-22, and (3) indazole carboxamides, such as 5F-AB-PINACA, 5F-AMB, and 5F-ADB. These SCs became available sequentially with increasing cannabinoid CB1 agonist potencies and reached a nationwide outbreak in the summer of 2014...
2017: Forensic Toxicology
https://www.readbyqxmd.com/read/28689194/risk-factors-and-outcomes-associated-with-post-traumatic-headache-after-mild-traumatic-brain-injury
#12
Yilmaz Tansel, Gerwin Roks, Myrthe de Koning, Myrthe Scheenen, Harm van der Horn, Gerben Plas, Gerard Hageman, Guus Schoonman, Jacoba Spikman, Joukje van der Naalt
OBJECTIVES: To determine the prevalence and potential risk factors of acute and chronic post-traumatic headache (PTH) in patients with mild to moderate traumatic brain injury (TBI) in a prospective longitudinal observational multicentre study. Acute PTH (aPTH) is defined by new or worsening of pre-existing headache occurring within 7 days after trauma, whereas chronic PTH (cPTH) is defined as persisting aPTH >3 months after trauma. An additional goal was to study the impact of aPTH and cPTH in terms of return to work (RTW), anxiety and depression...
July 8, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28688623/neuropsychiatric-debut-as-a-presentation-of-guillain-barr%C3%A3-syndrome-an-atypical-clinical-case-and-literature-review
#13
Dinesh Sangroula, Richard Durrance, Shirshak Bhattarai, Thambirajah Nandakumar
INTRODUCTION: Guillain Barré Syndrome (GBS) is an acute immune-mediated polyneuropathy most frequently presenting two to four weeks after an acute mild-moderately severe infection as progressive muscular weakness of the lower limbs extending proximally with dysreflexia and autonomic dysfunction. While GBS is typically believed to be isolated to the Peripheral Nervous System, Central Nervous System (CNS) and psychiatric manifestations as a sequela of the disease have been described in different imaging and clinical studies...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28686806/hippocampal-damage-causes-retrograde-but-not-anterograde-memory-loss-for-context-fear-discrimination-in-rats
#14
Justin Q Lee, Robert J Sutherland, Robert J McDonald
There is a substantial body of evidence that the hippocampus (HPC) plays and essential role in context discrimination in rodents. Studies reporting anterograde amnesia (AA) used repeated, alternating, distributed conditioning and extinction sessions to measure context fear discrimination. In addition, there is uncertainty about the extent of damage to the HPC. Here, we induced conditioned fear prior to discrimination tests and rats sustained extensive, quantified pre- or post-training HPC damage. Unlike previous work, we found that extensive HPC damage spares context discrimination, we observed no AA...
July 7, 2017: Hippocampus
https://www.readbyqxmd.com/read/28686702/what-is-the-level-of-evidence-for-the-amnestic-effects-of-sedatives-in-pediatric-patients-a-systematic-review-and-meta-analyses
#15
Karolline Alves Viana, Anelise Daher, Lucianne Cople Maia, Paulo Sucasas Costa, Carolina de Castro Martins, Saul Martins Paiva, Luciane Rezende Costa
BACKGROUND: Studies have suggested that benzodiazepines are amnestic drug par excellence, but when taken together, what level of evidence do they generate? Are other sedatives as amnestic as benzodiazepines? The aim of this study was to assess the level of scientific evidence for the amnestic effect of sedatives in pediatric patients who undergo health procedures. METHODS: The literature was searched to identify randomized controlled trials that evaluated anterograde and retrograde amnesia in 1-19-year-olds who received sedative drugs during health procedures...
2017: PloS One
https://www.readbyqxmd.com/read/28677245/does-age-matter-a-mixed-methods-study-examining-determinants-of-good-recovery-and-resilience-in-young-and-middle-aged-adults-following-moderate-to-severe-traumatic-brain-injury
#16
Caroline Arbour, Nadia Gosselin, Marie-Josée Levert, Jérôme Gauvin-Lepage, Bernard Michallet, Hélène Lefebvre
AIM: To examine whether age contributes to functional recovery and resilience after moderate-to-severe traumatic brain injury. BACKGROUND: The ability to recover may change across the lifespan, but the influence of age on brain injury outcome is understudied. DESIGN: Mixed methods study. METHODS: All adults of working-age (18-64 years), discharged from a Level I trauma center between 2010-2013 after sustaining a moderate-to-severe traumatic brain injury were considered...
July 5, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28676317/anterograde-amnesia-and-disorientation-are-associated-with-in-patients-without-traumatic-brain-injury-taking-opioids-retrograde-amnesia-ra-is-absent-ra-assessment-should-be-integral-to-post-traumatic-amnesia-testing
#17
Jessica McLellan BPsych, Laurence A G Marshman, Maria Hennessy
The Glasgow Coma Scale (GCS) only assesses orientation after traumatic brain injury (TBI). 'Post-traumatic amnesia' (PTA) comprises orientation, anterograde amnesia (AA) and retrograde amnesia (RA). However, RA is often disregarded in formalized PTA assessment. Drugs can potentially confound PTA assessment: e.g. midazolam can cause AA. However, potential drug confounders are also often disregarded in formalized PTA testing. One study of medium-stay elective-surgery orthopaedic patients (without TBI) demonstrated AA in 80% taking opiates after general anesthesia...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28669658/vascular-risk-factors-and-internal-jugular-venous-flow-in-transient-global-amnesia-a-study-of-165-japanese-patients
#18
Takahiro Himeno, Masaru Kuriyama, Makoto Takemaru, Yuhei Kanaya, Yuji Shiga, Shinichi Takeshima, Kazuhiro Takamatsu, Yutaka Shimoe, Tomoko Fukushima, Etsuro Matsubara
BACKGROUND: The etiology of transient global amnesia (TGA) remains unclear. We studied the pathophysiology of TGA in 165 Japanese patients. SUBJECTS AND METHODS: TGA was diagnosed in hospitalized patients from 2004 to 2015. We analyzed clinical characteristics, magnetic resonance imaging findings, and maximum intima-media thickness of the common carotid artery, and the reflux of internal jugular venous (IJV) flow by ultrasonography, and statistically compared patients with TGA with age-matched and sex-matched patients who have had a transient ischemic attack (TIA), small-vessel occlusion (SVO), and normal controls (each group, N = 165)...
June 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28663619/comparison-of-the-effects-of-four-subdoses-of-dextroketamine-to-reduce-pain-during-posterior-brachial-plexus-block-a-randomized-double-blind-study
#19
Luiz Eduardo Imbellon, Marildo A Gouveia, Geraldo Borges de Morais Filho
BACKGROUND: The needle puncture produces discomfort during regional anesthesia. Sedation and local anesthesia are used to promote analgesia and amnesia. The main objective of this study was to compare the efficacy of four subanesthetic doses of dextroketamine for pain relief during brachial plexus block via the posterior approach. MATERIALS AND METHODS: Patients American Society of Anesthesiology I and II programed for elective surgery under brachial plexus block were distributed at randomized into four groups of twenty patients...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28661172/visual-complexity-accentuates-picture-description-deficit-in-amnesia
#20
Michaela Dewar, Maria Adriana Neroni, Adam Zeman, Nicoletta Beschin, Sergio Della Sala
OBJECTIVE: A recent study indicated that amnesic patients have difficulties not only in describing past and imagined scenarios, but also in describing pictures that are in full view. This finding suggests that impaired memory hampers descriptions of scenarios more broadly. However, no such impairment in picture description in amnesic patients was observed in a related study. One key methodological difference between these studies was the complexity of the pictures to be described, hinting that group differences might be marked only if pictures are sufficiently complex to tax aspects of memory...
June 29, 2017: Neuropsychology
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