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Platelet-rich plasma

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https://www.readbyqxmd.com/read/29675502/survival-analysis-after-core-decompression-in-association-with-platelet-rich-plasma-mesenchymal-stem-cells-and-synthetic-bone-graft-in-patients-with-osteonecrosis-of-the-femoral-head
#1
Riccardo D'Ambrosi, Elena Biancardi, Giulia Massari, Vincenza Ragone, Renato Mario Facchini
Purpose  The aim of this study was to report the rate of survivorship in patients with osteonecrosis of the femoral head treated with core decompression in association with mesenchymal stem cells (MSCs) implantation, platelet-rich plasma (PRP) injection, and synthetic bone graft. Methods  We evaluated 24 hips in 16 patients, according to Ficat classification, treated by core decompression, injection of PRP and MSCs, and backfilling of the core tract with synthetic bone graft. Survivorship was estimated using Kaplan-Meier curves...
March 2018: Joints
https://www.readbyqxmd.com/read/29671861/p2y12-antagonist-ticagrelor-inhibits-the-release-of-procoagulant-extracellular-vesicles-from-activated-platelets-preliminary-results
#2
Aleksandra Gasecka, Rienk Nieuwland, Edwin van der Pol, Najat Hajji, Agata Ćwiek, Kinga Pluta, Michał Konwerski, Krzysztof J Filipiak
BACKGROUND: Activated platelets release platelet extracellular vesicles (PEVs). Adenosine diphosphate (ADP) receptors P2Y1 and P2Y12 both play a role in platelet activation, The present hypothesis herein is that the inhibition of these receptors may affect the release of PEVs. METHODS: Platelet-rich plasma from 10 healthy subjects was incubated with saline, P2Y1 antagonist MRS2179 (100 µM), P2Y12 antagonist ticagrelor (1 µM), and a combination of both antagonists...
April 19, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29668626/effect-of-arthrocentesis-plus-platelet-rich-plasma-and-platelet-rich-plasma-alone-in-the-treatment-of-temporomandibular-joint-osteoarthritis-a-retrospective-matched-cohort-study-a-strobe-compliant-article
#3
Shang-Lun Lin, Chiang-Chin Tsai, Shang-Liang Wu, Shun-Yao Ko, Wei-Fan Chiang, Jung Wu Yang
Although the research on using platelet-rich plasma (PRP) for temporomandibular joint osteoarthritis (TMJ-OA) has advanced, no unified standards exist for determining the joint use of arthrocentesis and the injection dose and frequency of PRP. This study aimed to compare the efficacy of 2 TMJ-OA treatment approaches, arthrocentesis plus platelet-rich plasma (A+PRP) and PRP alone, and attempted to provide another potential treatment option with a single injection of 2 mL of high-concentration and high-purity PRP...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667850/a-survey-of-fellowship-trained-upper-extremity-surgeons-on-treatment-of-lateral-epicondylitis
#4
Steven R Niedermeier, Nisha Crouser, Amy Speeckaert, Kanu S Goyal
BACKGROUND: The aim of the study is to investigate current management strategies for lateral epicondylitis by fellowship-trained upper extremity surgeons. METHODS: A 17-question survey of treatment approaches and outcomes related to lateral epicondylitis was sent to 3354 surgeons using the American Society for Surgery of the Hand and American Shoulder and Elbow Surgeons member databases. RESULTS: Six hundred twelve upper extremity surgeons completed the survey...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29663706/patient-specific-bioinks-for-3d-bioprinting-of-tissue-engineering-scaffolds
#5
Negar Faramarzi, Iman K Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N Ruskin, Ali Tamayol
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663626/treatment-of-auricular-keloids-by-triple-combination-therapy-surgical-excision-platelet-rich-plasma-and-cryosurgery
#6
Ehab Zaki Azzam, Salma Samir Omar
BACKGROUND: Surgical excision alone for auricular keloids is frequently followed by recurrence making combining treatment options necessary. OBJECTIVE: We aimed to assess the long-term efficacy of combining surgical excision, cryosurgery, and platelet-rich plasma (PRP) in treatment of auricular keloids. METHODS: This interventional study was carried out on fifty auricular keloids in 50 patients. Patients were subjected to a combination therapy of surgical excision of the keloids, intraoperative cryosurgery, and PRP injections...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29661222/platelet-rich-plasma-enhances-the-proliferation-of-human-adipose-stem-cells-through-multiple-signaling-pathways
#7
Fangyuan Lai, Natsuko Kakudo, Naoki Morimoto, Shigeru Taketani, Tomoya Hara, Takeshi Ogawa, Kenji Kusumoto
BACKGROUND: Platelet-rich plasma (PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived stem cells (hASCs). PRP stimulates proliferation of hASCs; however, the signaling pathways activated by PRP remain unclear. METHODS: hASCs were cultured with or without PRP or PDGF-BB, and proliferation was assessed. hASCs were also treated with PRP or PDGF-BB with or without imatinib, which is a PDGF receptor tyrosine kinase inhibitor, or sorafenib, which is a multikinase inhibitor...
April 16, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29657476/platelet-rich-plasma-injections-for-lateral-epicondylitis-of-the-elbow-reduce-the-need-for-surgical-intervention
#8
Graham Hastie, Mazen Soufi, James Wilson, Bibhas Roy
Objective: We aimed to assess the effectiveness of PRP injections in lateral epicondylitis of the elbow as it was felt after PRP introduction the numbers of patients requiring surgery for had reduced. Methods: We conducted a retrospective review of cases from the 1st January 2008 to 31st December 2015. The numbers of patients undergoing surgical release and the numbers of patients requiring PRP injections were recorded each year and the numbers of patients requiring surgery was compared pre and post PRP injection to ascertain if PRP introduction reduced surgical intervention...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656808/injections-for-knee-osteoarthritis-corticosteroids-viscosupplementation-platelet-rich-plasma-and-autologous-stem-cells
#9
David M Levy, Kyle A Petersen, Margie Scalley Vaught, David R Christian, Brian J Cole
This article reviews the benefits of corticosteroid, viscosupplementation, platelet-rich plasma, and autologous mesenchymal stem cell injections for the treatment of patients with knee osteoarthritis. Integrating injections into both clinical and surgical practices is complicated given existing health insurance reimbursement policies. This review describes the outcomes associated with these interventions and appropriate methods of navigating the existing reimbursement pathways to help providers implement these treatments into their practices...
April 12, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29656764/prescribing-habits-for-androgenic-alopecia-among-dermatologists-in-spain-in-2017-a-cross-sectional-study
#10
C Pindado-Ortega, D Saceda-Corralo, D Buendía-Castaño, P Fernández-González, Ó M Moreno-Arrones, P Fonda-Pascual, A Alegre-Sánchez, A R Rodrigues-Barata, S Vañó-Galván
BACKGROUND: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). MATERIAL AND METHODS: Descriptive cross-sectional study using online questionnaires completed by dermatologists working in Spain...
April 12, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29649372/autogenous-bone-graft-versus-bovine-bone-graft-in-association-with-platelet-rich-plasma-for-the-reconstruction-of-alveolar-clefts-a-pilot-study
#11
Bruno Torres Bezerra, John Nadson Andrade Pinho, Fabrício Eneas Diniz Figueiredo, José Renato Moraes Carvalho Barreto Brandão, Lucas Celestino Guerzet Ayres, Luiz Carlos Ferreira da Silva
OBJECTIVE: To compare the outcomes of 2 different bone graft materials: autogenous bone grafts from mandibular symphysis and bovine bone grafts associated with platelet-rich plasma (PRP). METHODS: Twenty individuals met the inclusion criteria and accepted to participate in the study. Group A patients underwent alveolar bone grafting using autologous bone and group B patients using a bovine bone graft associated with PRP. Cone beam computed tomography scans were taken and reconstructed 3-dimensionally for all patients preoperatively and 1 year postoperatively...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29644468/-pharmacological-treatment-of-osteoarthritis-related-pain
#12
REVIEW
T A Nees, M Schiltenwolf
Joint pain due to osteoarthritis (OA) is often severe and disabling and affects a large proportion of the aging population impairing daily living and quality of life. Numerous pharmacological treatment approaches are available. Including major OA guidelines this review presents the current evidence of pharmacological therapies in OA-related pain and covers topical, oral and intraarticular treatment approaches. In patients with mild OA topical nonsteroidal antiinflammatory drugs (NSAIDs) can be recommended...
April 11, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29628381/biological-treatment-for-osteoarthritis-of-the-knee-moving-from-bench-to-bedside-current-practical-concepts
#13
Jorge Chahla, Bert R Mandelbaum
Biological-based therapies for cartilage pathology have gained considerable recognition in the last few decades due to their potential benefits including their minimal invasiveness, capacity for unprecedented healing, and potential for rapid recovery. Consequently, these therapies are likely to have the most noteworthy impact on patients with degenerative joint changes who want to remain active. Currently, the most researched treatments include platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and cell-based therapies...
April 5, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29626641/platelet-rich-plasma-versus-hyaluronic-acid-in-patients-with-hip-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Ye Ye, Xiang Zhou, Shuiwei Mao, Jun Zhang, Bingmin Lin
BACKGROUND: This study aims to compare the efficacy of intra-articular injection of hyaluronic acid (HA) and platelet-rich plasma (PRP) for treating hip osteoarthritis (OA). METHODS: We performed systematic searches in PubMed, EmBase, ScienceDirect Web of science and the Cochrane Library for relevant literature published in or before February 2018. Only randomized controlled trials (RCTs) were included. The risk of bias assessment was performed using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5...
April 4, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29619095/platelet-rich-plasma-in-reconstruction-of-posterior-meatal-wall-after-canal-wall-down-mastoidectomy
#15
Mohammad El-Sayed Abd Elbary, Wail Fayez Nasr, Samir Sorour Sorour
Introduction  Canal wall down (CWD) mastoidectomy has many drawbacks, including chronic otorrhea not responding to medications, granulations, dizziness on exposure to cold or hot water, and tendency of debris accumulation in the mastoid cavity, demanding periodic cleaning. Many of these problems can be solved by reconstruction of the posterior meatal wall (PMW). Objectives  To assess the results of PMW reconstruction after CWD mastoidectomy for cholesteatoma using titanium mesh and platelet-rich plasma (PRP) mixed with bone pate...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29617719/platelet-rich-plasma-adipose-tissue-and-scar-modulation
#16
Lohrasb R Sayadi, Zaidal Obagi, Derek A Banyard, Mary E Ziegler, Jordyne Prussak, Luke Tomlinson, Gregory R D Evans, Alan D Widgerow
In developed countries, over 100 million people per year form scars, of which 30% become hypertrophic. These scars are defined histologically by the presence of persistently contractile myofibroblasts. Recent in vitro research suggests that certain bone morphogenic proteins (BMP) can induce scar myofibroblast dedifferentiation and reprogramming into adipocytes. Since platelets contain BMPs within their granules, it is possible that platelet-rich plasma (PRP) can act as a vehicle to deliver BMP to sites of scarring or potential scarring...
March 30, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29614519/clinical-determinants-of-thrombin-generation-measured-in-presence-and-absence-of-platelets-results-from-the-gutenberg-health-study
#17
Marina Panova-Noeva, Andreas Schulz, Henri M Spronk, Aline Beicht, Dagmar Laubert-Reh, Rene van Oerle, Natalie Arnold, Jürgen H Prochaska, Maria Blettner, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J Lackner, Hugo Ten Cate, Philipp S Wild
The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might be an important indicator of prothrombotic risk linked to cardiovascular disease (CVD), but the presence of platelets may be a critical determinant. Clinical data, laboratory markers and thrombin generation (TG), investigated in both platelet-rich plasma (PRP) and platelet-free plasma (PFP) at 1 pM TF, were available in 407 individuals from the Gutenberg Health Study. Given the well-known effect of anticoagulants on TG, subjects taking anticoagulants ( n  = 15) have been excluded resulting in 392 subjects for further analysis...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29614518/hypobaric-hypoxia-causes-elevated-thrombin-generation-mediated-by-fviii-that-is-balanced-by-decreased-platelet-activation
#18
Cécile H Kicken, Marisa Ninivaggi, Joke Konings, Martijn Moorlag, Dana Huskens, Jasper A Remijn, Saartje Bloemen, Marcus D Lancé, Bas De Laat
INTRODUCTION:  Epidemiological studies suggest that hypobaric hypoxia at high altitude poses a risk for developing venous thromboembolism. The cause of this observed hypercoagulability remains unclear. Therefore, this study aimed to investigate the effect of hypobaric hypoxia at 3,883 m above sea level on thrombin generation and platelet activation. METHODS:  After complying with medical ethical procedures, 18 participants were recruited, of whom 1 had to leave the study prematurely due to mild acute mountain sickness...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29608489/enhanced-osteogenic-differentiation-of-mesenchymal-stem-cells-on-electrospun-pes-pva-prp-nanofibrous-scaffolds
#19
Mahshid Sadat Kashef-Saberi, Nasim Hayati Roodbari, Kazem Parivar, Saeid Vakilian, Hana Hanee-Ahvaz
Over the last few decades, great advancements have been achieved in the field of bone tissue engineering (BTE). Containing a great number of growth factors needed in the process of osteogenesis, platelet rich plasma (PRP) has gained a great deal of attention. However, due to the contradictory results achieved in different studies, its effectiveness remains a mystery. Therefore, in this study, we investigated in vitro performance of co-electrospun PRP/poly ether sulfone/poly(vinyl) alcohol (PRP/PES/PVA) composite scaffolds for the osteogenic differentiation of human adipose-derived mesenchymal stem cells...
March 28, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29608156/effects-of-allogeneic-platelet-rich-plasma-prp-on-the-healing-process-of-sectioned-achilles-tendons-of-rats-a-methodological-description
#20
Laura Greimers, Pierre V Drion, Alain Colige, Vincent Libertiaux, Vincent Denoël, Christelle Lecut, André Gothot, Jean-François Kaux
This article describes the experimental procedures used to observe if PRP can positively affect tendon healing. There are 4 main steps to follow: induce a lesion in the Achilles tendon; prepare PRP and inject it (or the saline solution); remove the tendon; and perform biomechanical, molecular, and histological evaluations. At each step, all the procedures and methods are described in detail, so they can be reproduced easily. Achilles tendons have been surgically sectioned (removal of a 5-mm long section). Afterwards, PRP or saline solution was injected to study whether PRP has a positive effect on the healing of the tendon...
March 19, 2018: Journal of Visualized Experiments: JoVE
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