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Platelet-rich plasma

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https://www.readbyqxmd.com/read/29228441/correlation-between-individual-inflammation-genetic-profile-and-platelet-rich-plasma-efficacy-in-hair-follicle-regeneration-a-pilot-study-reveals-prognostic-value-of-il-1a-polymorphism
#1
F Rossano, S Di Martino, L Iodice, M Di Paolo, S Misso, R Tomeo, A M Marini, R Brugnone, S Marlino, A Santorelli, R Di Francia
OBJECTIVE: Hair loss generates severe psychosocial implications. To date, exploring the prognostic factors of possible clinical benefit of autologous blood concentrate platelet rich plasma (PRP) was failed. The aim of our pilot study was to explore the correlation between the individual inflammation genetic profile and PRP efficacy in the treatment of hair follicle regeneration. PATIENTS AND METHODS: 41 volunteers (25 men, 16 women) took part in this retrospective study...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228282/proteolytic-inactivation-of-adamts13-by-plasmin-in-human-plasma-risk-of-thrombotic-thrombocytopenic-purpura
#2
Yongchol Shin, Haruki Miyake, Kenshi Togashi, Ryuichi Hiratsuka, Kana Endou-Ohnishi, Yasutada Imamura
Thrombotic thrombocytopenic purpura (TTP) is caused by inactivation of a von Willebrand factor (VWF)-cleaving enzyme, ADAMTS13, which leads to platelet-rich thrombi comprising unusually large VWF multimers. We have found that ADAMTS13 can bind to the inactivated form of plasmin. In addition, plasmin cleaves purified ADAMTS13 into several fragments and inactivates it. Hence, we hypothesized that activation of plasminogen to plasmin becomes a new-onset factor for TTP due to ADAMTS13 inactivation. Plasmin was added exogenously or activated from plasminogen by streprokinase addition in HP...
December 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29226987/protective-effect-of-platelet-rich-plasma-on-urethral-injury-model-of-male-rats
#3
Hasan H Tavukcu, Ömer Aytaç, Fatih Atuğ, Burçin Alev, Özge Çevik, Nurdan Bülbül, Ayşen Yarat, Şule Çetinel, Göksel Şener, Haluk Kulaksızoğlu
AIMS: Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet-rich plasma (PRP) on a urethral injury (UI) model of male rats. METHODS: A UI model was used by applying a coagulation current to the urethras of male rats. There were four groups with six rats in each: control group, PRP applied to naive urethra, UI group, and UI with PRP application...
December 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29226630/microneedling-combined-with-platelet-rich-plasma-or-trichloroacetic-acid-peeling-for-management-of-acne-scarring-a-split-face-clinical-and-histologic-comparison
#4
Moetaz El-Domyati, Hossam Abdel-Wahab, Aliaa Hossam
BACKGROUND: Minimally invasive procedures provide effective, safe, relatively long-lasting, and natural results without large damage to the skin. A combination treatment is considered an approach that includes at least 2 different and unrelated modalities. OBJECTIVES: This study aims to evaluate the use and effectiveness of some combined minimally invasive procedures for management of acne scarring. PATIENTS/METHODS: Twenty-four volunteers with postacne atrophic scars were randomly divided into 3 equal groups according to performed procedure on each side of the face (microneedling by dermaroller alone or combined with platelet-rich plasma [PRP] or trichloroacetic acid [TCA] 15% peeling) and received 6 bi-weekly sessions of treatment...
December 10, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29226205/clinical-results-of-platelet-rich-plasma-for-partial-thickness-rotator-cuff-tears-a-case-series
#5
Zohreh Zafarani, Fateme Mirzaee, Mohamadreza Guity, Hamidreza Aslani
Partial thickness rotator cuff tears (PTRCTs) are a common pathology among shoulder disorders in people over 50 years. Treatment of PTRCTs remains controversial. Most studies on the treatment of PTRCTs have explained surgical techniques or outcomes; few studies have centralized on the conservative and new management of PTRCTs, like treatment with Platelet-rich plasma (PRP). These case series study have been conducted on Platelet-rich plasma (PRP) injection, as a concentrated source of cytokines that can stimulate healing of soft tissue...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29226136/a-new-platelet-aggregation-inhibiting-factor-isolated-from-bothrops-moojeni-snake-venom
#6
Bruna Barbosa de Sousa, Carla Cristine Neves Mamede, Mariana Santos Matias, Déborah Fernanda da Cunha Pereira, Mayara Ribeiro de Queiroz, Edigar Henrique Vaz Dias, Anielle Christine Almeida Silva, Noelio Oliveira Dantas, Júnia de Oliveira Costa, Fábio de Oliveira
This work reports the purification and functional characterization of BmooPAi, a platelet-aggregation-inhibiting factor from Bothrops moojeni snake venom. The toxin was purified by a combination of three chromatographic steps (ion-exchange on DEAE-Sephacel, molecular exclusion on Sephadex G-75, and affinity chromatography on HiTrap™ Heparin HP). BmooPAi was found to be a single-chain protein with an apparent molecular mass of 32 kDa on 14% SDS-PAGE, under reducing conditions. Sequencing of BmooPAi by Edman degradation revealed the amino acid sequence LGPDIVPPNELLEVM...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29215839/-interaction-of-epinephrine-and-adp-in-regulation-of-platelet-function-in-chronic-cerebral-ischemia
#7
E F Barinov, S A Mamedaliyeva, T A Tverdokhleb, A O , Balykina
The purpose is devoted to test of hypothesis that patients with chronic cerebral ischemia (CCI) have decreased secretion of platelet ADP as the reason of platelet aggregation restriction in response to stimulation of adrenaline. Methods. We used platelet-rich plasma which was separated by centrifugation from peripheral blood of 55 patients with a diagnosis of CCI of stage 1-2. Platelets aggregation was studied on aggregometer Chrono - Log (USA). ADP and Epinephrine were used for platelet stimulation at effective concentration (EC50)...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29215443/scaffold-free-bone-regeneration-using-platelet-rich-fibrin-in-calvarial-defect-model
#8
Yeo Reum Jeon, Mi Jung Kim, Yong Oock Kim, Tai Suk Roh, Won Jai Lee, Eun Hye Kang, In Sik Yun
Bone regeneration is a complex process influenced by various physiological factors. Platelet-rich plasma (PRP) contains many growth factors and has shown osteogenic effects. The PRP is usually activated before use. However, the authors showed that nonactivated PRP (nPRP) and activated PRP have comparable osteogenic effects in the previous study. Generally, a scaffold has been needed for the application of PRP in the cranial defect model. In this study, the authors aimed to compare the performance of scaffold free platelet-rich fibrin (PRF) to nPRP as an adjuvant for bone regeneration...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29215166/effectiveness-of-platelet-rich-plasma-therapy-in-wound-healing-of-pilonidal-sinus-surgery-a-comprehensive-systematic-review-and-meta-analysis
#9
Shayan Mostafaei, Fatemeh Norooznezhad, Saeed Mohammadi, Amir Hossein Norooznezhad
BACKGROUND: Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. METHODS: For this meta-analysis, a search in Medline, Embase and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages...
December 7, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29214094/study-of-a-two-step-centrifugation-protocol-for-concentrating-cells-and-growth-factors-in-bovine-platelet-rich-plasma
#10
Claudia M Gutiérrez, Catalina López, Carlos E Giraldo, Jorge U Carmona
There is a lack of information about the methods used for bovine platelet-rich plasma (PRP)/platelet-rich gel (PRG) procurement, including information on platelet (PLT), white blood cell (WBC) in PRP, and growth factor release from PRG supernatants. The aims of this study were to compare and to correlate the PLT, WBC, transforming growth factor beta-1 (TGF-β1), and platelet-derived growth factor BB (PDGF-BB) concentrations in bovine whole blood, plasma, and four PRP layers and their respective PRG supernatants: A and B (obtained by a single centrifugation tube method at 720g/5 min) and C and D (obtained by a double centrifugation tube method, by using two centrifugation episodes at 720g/5 min)...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29211969/use-of-platelet-rich-plasma-immediately-after-an-injury-did-not-improve-ligament-healing-and-increasing-platelet-concentrations-was-detrimental-in-an-in-vivo-animal-model
#11
Robert F LaPrade, Laurie R Goodrich, Jennifer Phillips, Grant J Dornan, Travis Lee Turnbull, Michael L Hawes, Kimi D Dahl, Ashley N Coggins, John Kisiday, David Frisbie, Jorge Chahla
BACKGROUND: Limited information in basic science and clinical trials exists to determine if ligament healing may be accelerated with the use of biological adjuvants, such as platelet-rich plasma (PRP). However, there has been widespread acceptance of PRP for use in clinical practice, despite an inadequate understanding of its biological mechanism of action. PURPOSE: To determine whether a single dose of PRP could accelerate ligament healing and correspondingly improve histological characteristics and biomechanical properties when injected immediately postoperatively into the injured medial collateral ligament (MCL) of New Zealand White rabbits...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29211968/men-and-women-differ-in-the-biochemical-composition-of-platelet-rich-plasma
#12
Grace Xiong, Nithya Lingampalli, Jayme C B Koltsov, Lawrence L Leung, Nidhi Bhutani, William H Robinson, Constance R Chu
BACKGROUND: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use. HYPOTHESIS: Age and sex influence the PRP composition in healthy patients. STUDY DESIGN: Controlled laboratory study...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29210705/effects-of-platelet-rich-plasma-on-pain-and-muscle-strength-in-patients-with-knee-osteoarthritis
#13
Yung-Tsan Wu, Kao-Chih Hsu, Tsung-Ying Li, Cheng-Kuang Chang, Liang-Cheng Chen
OBJECTIVE: No studies comparing the effects of platelet-rich plasma (PRP) injection and placebo injection in bilateral knee osteoarthritis (OA) in the same patient, or discussing muscle strength after PRP injection, have been published. DESIGN: Twenty patients with bilateral knee OA were eligible, and 40 knees were randomized into two groups: PRP (knees [right or left by a coin toss] receiving a single intra-articular PRP injection) and saline group (the contralateral knee of the same patient, into which single 4-mL intra-articular injection of normal saline was administered)...
November 29, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29210206/intra-articular-platelet-rich-plasma-injections-for-knee-osteoarthritis-an-overview-of-systematic-reviews-and-risk-of-bias-considerations
#14
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Numerous systematic reviews investigating the efficacy of platelet-rich plasma (PRP) in treating knee osteoarthritis (OA) have been recently published. The purpose of the present study was (1) to perform an overview of overlapping systematic reviews investigating PRP for knee OA via evaluating methodological quality and risk of bias of systematic reviews and (2) to provide recommendations through the best evidence. METHODS: A systematic search of systematic reviews published through Feb 2017 was conducted using the MEDLINE, EMBASE and Cochrane Library...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29209937/sugar-based-collagen-membrane-cross-linking-increases-barrier-capacity-of-membranes
#15
Po-Ju Chia-Lai, Anna Orlowska, Sarah Al-Maawi, Andre Dias, Yunxin Zhang, Xuejiu Wang, Niklas Zender, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
OBJECTIVES: This study examines the permeability and barrier capacity of a sugar cross-linked resorbable collagen membrane ex vivo and in vivo. MATERIALS AND METHODS: In an ex vivo study, injectable platelet-rich fibrin (i-PRF), a peripheral blood-derived human leukocyte-and-platelet-rich plasma was used to analyze membrane permeability. in vivo subcutaneous implantation in Wistar rats (n = 4 per time point and group) was used to investigate the barrier capacity of the membrane...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29207216/the-roles-of-cellular-and-molecular-components-of-a-hematoma-at-early-stage-of-bone-healing
#16
REVIEW
Hoi Ting Shiu, Ping Chung Leung, Chun Hay Ko
Bone healing is a complex repair process which commences with formation of a blood clot at the injured bone, termed hematoma. It has evidenced that a lack of a stable hematoma causes delayed bone healing or non-union. The hematoma at the injured bone constitutes the early healing microenvironment. It appears to dictate healing pathways which ends in a regenerative bone. However, the hematoma is often clinically removed from the damaged site. Conversely, blood-derived products have been used in bone tissue engineering for treating critical sized defects (CSDs), including fibrin gels and platelet rich plasma...
December 5, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29207140/platelet-rich-plasma-inhibits-rankl-induced-osteoclast-differentiation-through-activation-of-wnt-pathway-during-bone-remodeling
#17
Dongyue Wang, Yajuan Weng, Shuyu Guo, Yuxin Zhang, Tingting Zhou, Mengnan Zhang, Lin Wang, Junqing Ma
Platelet-rich plasma (PRP) is used in the clinic as an autologous blood product to stimulate bone regeneration and chondrogenesis. Numerous studies have demonstrated that PRP affects bone remodeling by accelerating osteoblast formation. With the research perspective focusing on osteoclasts, the present study established a mouse model of mandibular advancement to examine the effect of PRP on osteoclast differentiation induced by modification of the dynamics of the temporomandibular joint (TMJ). The lower incisors of the mice were trimmed by 1 mm and the resultant change in mandibular position during the process of eating induced condylar adaptation to this change...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29204390/platelet-rich-plasma-by-single-spin-process-in-male-pattern-androgenetic-alopecia-is-it-an-effective-treatment
#18
Arshdeep
No abstract text is available yet for this article.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204389/platelet-rich-plasma-by-single-spin-process-in-male-pattern-androgenetic-alopecia-is-it-an-effective-treatment
#19
Azin Ayatollahi, Hamed Hosseini, Majid Shahdi, Saman AhmadNasrollahi, Mansour NassiriKashani, Somaye Yadangi, Farid H Firooz, Alireza Firooz
Introduction and Objective: Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma. The platelet is a natural source of different growth factors and cytokines. These growth factors act on stem cells in the bulge area of the follicles and stimulate the development of new follicles, and promote neovascularization. The aim of this study was to investigate the efficacy and safety of PRP injections in androgenetic alopecia (AGA) in men. Patients and Methods: Fifteen male patients (mean age: 39 ± 9...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29194786/microneedling-for-the-treatment-of-hair-loss
#20
REVIEW
Raymond M Fertig, A Caresse Gamret, Jessica Cervantes, Antonella Tosti
Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization, and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet rich plasma, and topical steroids, and shown to stimulate hair follicle growth...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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