keyword
https://read.qxmd.com/read/38544668/intrauterine-autologous-platelet-rich-plasma-treatment-in-women-with-at-least-two-implantation-failures-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Neda Fattahi Meybodi, Maryam Eftekhar, Behnaz Gandom
BACKGROUND: Finding the most effective way to improve implantation rate in women who are receiving assisted reproductive technology treatment is still a challenge. OBJECTIVE: This study aimed to assess the pregnancy outcomes of intrauterine platelet-rich plasma (PRP) therapy in women with a history of at least 2 implantation failures. MATERIALS AND METHODS: In this retrospective cohort study, data of 852 women who were candidates for frozen-thawed embryo transfer was extracted from their medical records from April 2017 to September 2021 at Yazd Reproductive Sciences Institute, Yazd, Iran...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38544388/resveratrol-and-tetrahydroisoquinoline-effects-on-neutrophil-sensitivity-to-netosis-formation-in-low-risk-essential-thrombocythemia-patients
#2
JOURNAL ARTICLE
Fahimeh Shahriyary, Mohammad Reza Amirzargar, Mahshid Vafajoo, Ahmad Kooshari, Ali Basi, Seyed Mohsen Razavi, Behnaz Gharegozlou, Minoo Shahidi
INTRODUCTION: Recent studies scrutinize how NETosis (a unique cell death mechanism of neutrophil), impacts thrombosis patients with essential thrombocythemia (ET). This research evaluates the susceptibility of ET neutrophils to form NETs and tests two potential inhibitors, resveratrol (RSV) and tetrahydroisoquinoline (THIQ), in vitro. METHODS: Platelet-rich plasma from low-risk ET patients was used, along with neutrophils from both patients and controls. NET formation assays, with or without RSV and THIQ treatment after LPS stimulation, were conducted in a CO2 incubator...
March 27, 2024: European Journal of Haematology
https://read.qxmd.com/read/38542399/mesenchymal-stromal-cells-derived-from-canine-adipose-tissue-evaluation-of-the-effect-of-different-shipping-vehicles-used-for-clinical-administration
#3
JOURNAL ARTICLE
Valentina Andreoli, Priscilla Berni, Virna Conti, Roberto Ramoni, Giuseppina Basini, Stefano Grolli
Mesenchymal Stromal Cells (MSCs)-based therapies are rapidly gaining interest in veterinary medicine. Cellular therapy represents a new challenge for practitioners and requires precise coordination between the cell processing laboratory and the veterinary clinic. Cryopreservation is the best method to provide fast, in-time, and long-distance delivery of cells for therapeutic applications. However, potentially toxic cryoprotectants and xenobiotic products make the direct administration of cells impracticable for patients...
March 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38538951/pharmacological-interventions-for-early-stage-frozen-shoulder-a-systematic-review-and-network-meta-analysis
#4
JOURNAL ARTICLE
Juan Enrique Berner, Marios Nicolaides, Stephen Ali, Georgios Pafitanis, Jane Preece, Sally Hopewell, Jagdeep Nanchahal
OBJECTIVES: To evaluate the efficacy of pharmacological interventions for treating early-stage, pain predominant, adhesive capsulitis, also known as frozen shoulder. METHODS: We performed a systematic review in accordance with PRSIMA guidelines. Searches were conducted on PUBMED, EMBASE and Cochrane Central Register of Controlled Trials on the 24th of February 2022. Outcomes were shoulder pain, shoulder function and range of movement. Synthesis involved both qualitative analysis for all studies and pairwise meta-analyses followed by a network meta-analysis for randomised controlled trials (RCTs)...
March 27, 2024: Rheumatology
https://read.qxmd.com/read/38537725/most-publications-regarding-platelet-rich-plasma-use-in-knee-are-from-asia-investigate-injection-for-osteoarthritis-and-show-outcome-improvement-a-scoping-review
#5
REVIEW
Henry Bg Baird, Cody C Ashy, Prudhvi Kodali, Gregory D Myer, Iain R Murray, William M Pullen, Harris S Slone
PURPOSE: To (1) evaluate and synthesize the available literature related to platelet-rich plasma (PRP) treatment of knee pathologies and (2) provide recommendations to inform future research in the field. METHODS: PubMed, CINAHL, and Scopus databases were queried on October 6, 2023. All identified citations were collated and uploaded into Covidence for screening and data extraction. Studies were included if they were human studies published in English with adult cohorts that received PRP as a procedural injection or surgical augmentation for knee pathologies with patient-reported outcome measures (PROMs) and level of evidence I-IV...
March 25, 2024: Arthroscopy
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#6
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534521/does-liquid-injectable-platelet-rich-fibrin-help-in-the-arthrocentesis-treatment-of-temporomandibular-joint-disorder-compared-to-other-infusion-options-a-systematic-review-of-randomized-clinical-trials
#7
REVIEW
Alexander Nemeth, Bruno Vasconcelos Gurgel, Adam Lowenstein, Luiz Juliasse, Rafael S Siroma, Zoe Zhu, Jamil Awad Shibli, Carlos Fernando Mourão
Temporomandibular joint disorders (TMDs) are prevalent musculoskeletal conditions involving pain and dysfunction of jaw mobility and function, which have proven difficult to treat satisfactorily. The present study aimed to assess the effectiveness of a liquid platelet-rich fibrin (i-PRF) infusion during arthrocentesis versus other options using coadjuvant materials to reduce TMD symptoms. A literature search was conducted using PubMed, EMBASE, Web of Science, Scopus, and ClinicalTrials.gov for RCTs published before January 2024, comparing i-PRF to any other TMD treatment...
March 2, 2024: Bioengineering
https://read.qxmd.com/read/38534483/optimization-of-platelet-rich-plasma-preparation-for-regenerative-medicine-comparison-of-different-anticoagulants-and-resuspension-media
#8
JOURNAL ARTICLE
Alexandra Carvalho, Ana Filipa Ferreira, Maria Soares, Susana Santos, Patrícia Tomé, Juliana Machado-Simões, Ana Sofia Pais, Ana Paula Sousa, Artur Paiva, Teresa Almeida-Santos
Platelet-rich plasma (PRP) has emerged as a promising therapy in regenerative medicine. However, the lack of standardization in PRP preparation protocols presents a challenge in achieving reproducible and accurate results. This study aimed to optimize the PRP preparation protocol by investigating the impact of two different anticoagulants, sodium citrate (SC) and ethylenediaminetetraacetic acid (EDTA), and resuspension media, plasma versus sodium chloride (NaCl). Platelet recovery rates were calculated and compared between groups, in addition to platelet activity and vascular endothelial growth factor (VEGF) released into plasma after PRP activation...
February 23, 2024: Bioengineering
https://read.qxmd.com/read/38531701/re-autologous-platelet-rich-plasma-a-prp-combined-with-pelvic-floor-muscle-training-for-the-treatment-of-female-stress-urinary-incontinence-sui-a-randomized-control-clinical-trial
#9
JOURNAL ARTICLE
Andrea Braga, Andrea Papadia, Maurizio Serati
No abstract text is available yet for this article.
March 25, 2024: European Urology
https://read.qxmd.com/read/38531532/effect-of-platelet-rich-plasma-on-healing-of-lower-extremity-diabetic-skin-ulcers-a-meta-analysis
#10
JOURNAL ARTICLE
Xiansong Fang, Xiaoling Wang, Ya Hou, Liang Zhou, Yingjie Jiang, Xiaoyun Wen
The aim of this research is to explore the therapeutic efficacy of platelet-rich plasma (PRP) on the cutaneous ulceration of diabetes mellitus (DM). From the beginning of the database until January 2024, we looked through several databases to obtain randomised, controlled PRP studies to treat the wound healing of DM in adult patients. The Cochrane Collaboration's Risk-Of-Bias Instrument was used to evaluate the risk of bias in randomised, controlled studies. Funnel plots, sensitivity analyses and Egger regression tests were employed to determine the reliability and effectiveness of the meta-analyses...
April 2024: International Wound Journal
https://read.qxmd.com/read/38530683/efficacy-of-intra-articular-corticosteroid-injection-for-nonsurgical-management-of-trapeziometacarpal-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
JOURNAL ARTICLE
Alexandra N Krez, Kevin A Wu, Kevin M Klifto, Tyler S Pidgeon, Christopher S Klifto, David S Ruch
PURPOSE: As osteoarthritis (OA) of the trapeziometacarpal (TMC) joint leads to a high degree of disease burden with compromises in rudimentary and fine movements of the hand, intra-articular injections may be a desirable treatment option. However, because there are no evidence-based guidelines, the choice of intra-articular injection type is left to the discretion of the individual surgeon in collaboration with the patient. The purpose of our study was to perform a systematic review and meta-analysis using level I studies to compare outcomes following corticosteroid and alternative methods of intra-articular injections for the management of TMC OA...
March 26, 2024: Journal of Hand Surgery
https://read.qxmd.com/read/38525952/postinjection-protocols-following-platelet-rich-plasma-administration-for-knee-osteoarthritis-a-systematic-review
#12
JOURNAL ARTICLE
Oscar Paul Levine, Koushik Kondapi, Vehniah Kristin Tjong, Chetan Gohal
OBJECTIVE: Platelet-rich plasma (PRP) use in treating orthopedic conditions has increased, yet evidence of its clinical efficacy is inconsistent and limited by heterogeneity in osteoarthritis (OA) severity, PRP preparations and protocols, and clinical outcome measurement. This review aims to characterize the variations in postinjection protocols in studies assessing the clinical efficacy of PRP for knee OA. LITERATURE SURVEY: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
March 25, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/38525908/platelet-rich-plasma-as-a-new-and-successful-treatment-for-lichen-planopilaris-a-controlled-blinded-randomized-clinical-trial
#13
JOURNAL ARTICLE
Elham Behrangi, Amirhossein Akbarzadehpasha, Abbas Dehghani, Sona Zare, Mohammadreza Ghassemi, Roya Zeinali, Azadeh Goodarzi, Zahra Lotfi
INTRODUCTION: Lichen planopilaris (LPP) is one of the most common causes of scarring hair loss caused by immune-mediated inflammation resulting in atrophy and scaling. The key to preventing this irreversible hair loss is diagnosing and starting treatment at the earliest possible stage. As there is no definite cure for LPP, the therapy could be challenging. In the study, we conducted a single-blinded randomized clinical trial to evaluate the therapeutic effects, safety, and tolerability of platelet-rich plasma versus topical clobetasol in the treatment of LPP...
March 25, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38525712/diagnostic-and-therapeutic-challenges-of-oligosymptomatic-vesicovaginal-fistula-in-the-complex-case-of-endometriosis
#14
Agnieszka A Strojny, Arkadiusz Baran, Katarzyna Wiejak, Anna Scholz, Radosław B Maksym
Endometriosis is a complex condition causing surgical challenges, sometimes leading to urogynecological complications, the diagnosis and treatment of which are not always obvious. We present a case of a 46-year-old woman with a history of severe endometriosis and adenomyosis who developed an oligosymptomatic vesicovaginal fistula (VVF) as a complication of surgery. The patient's medical history included multiple surgeries for endometriosis, a cesarean section, and a laparoscopic hysterectomy. After the excision of the full-thickness infiltration of the urinary bladder, she experienced postoperative bowel obstruction treated by laparotomy...
March 12, 2024: Clinics and Practice
https://read.qxmd.com/read/38525646/r-tpa-resistance-is-specific-for-platelet-rich-stroke-thrombi-and-can-be-overcome-by-targeting-nonfibrin-components
#15
JOURNAL ARTICLE
Sarah Vandelanotte, Olivier François, Linda Desender, Senna Staessens, Alexander Vanhoorne, Fréderick Van Gool, Claudia Tersteeg, Karen Vanhoorelbeke, Peter Vanacker, Tommy Andersson, Simon F De Meyer
BACKGROUND: Resistance to r-tPA (recombinant tissue-type plasminogen activator) is a well-known but poorly understood phenomenon that hampers successful recanalization in patients with acute ischemic stroke. Using clinically relevant thrombi from patients with acute ischemic stroke, we investigated if and how thrombus composition impacts r-tPA-mediated lysis. In addition, we explored strategies to overcome r-tPA resistance. METHODS: Thrombi were split into 2 parts, 1 of which was used for thrombolysis and the other for detailed histological analysis...
March 25, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38525288/degenerative-meniscus-tears-treated-nonoperatively-with-platelet-rich-plasma-yield-variable-clinical-and-imaging-outcomes-a-systematic-review
#16
REVIEW
Varun Gopinatth, Anjay K Batra, Jorge Chahla, Matthew V Smith, Matthew J Matava, Robert H Brophy, Derrick M Knapik
PURPOSE: To perform a systematic review on clinical and radiologic outcomes for meniscus tears treated nonoperatively with platelet-rich plasma (PRP). METHODS: A literature search was performed according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using keywords and Boolean operators in SCOPUS, PubMed, Medline, and the Cochrane Central Register for Controlled Trials in April 2023. Inclusion criteria were limited to Level I to IV human studies reporting on outcomes of meniscus tears treated nonoperatively with PRP...
April 2024: Arthroscopy, sports medicine, and rehabilitation
https://read.qxmd.com/read/38525222/the-activity-of-monocyte-derived-macrophages-after-stimulation-with-platelet-rich-and-platelet-poor-concentrates-study-on-an-ovine-model-of-insertion-of-a-tibial-implant-coated-with-silicon-doped-diamond-like-carbon
#17
JOURNAL ARTICLE
Bartłomiej Szymczak, Andrzej Junkuszew, Krzysztof Patkowski, Tomasz Szponder, Dominika Nguyen Ngoc, Beata Drzewiecka, Aleksandra Sobczyńska-Rak, Joanna Wessely-Szponder
INTRODUCTION: Macrophages are crucial immune cells that play a role in tissue repair and can exhibit pro- or anti-inflammatory behaviour based on environmental stimulation. Their functional phenotype can be affected by platelet-derived products as determined by those products' composition. When the inflammatory response caused by implantation is excessive, it can lead to rejection of the implant. Therefore, a thorough evaluation of implant haemocompatibility is necessary to minimise undesirable consequences...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38524692/perspective-on-intradiscal-therapies-for-lumbar-discogenic-pain-state-of-the-science-knowledge-gaps-and-imperatives-for-clinical-adoption
#18
JOURNAL ARTICLE
Morgan P Lorio, Jordan Lee Tate, Thomas J Myers, Jon E Block, Douglas P Beall
Specific clinical diagnostic criteria have established a consensus for defining patients with lumbar discogenic pain. However, if conservative medical management fails, these patients have few treatment options short of surgery involving discectomy often coupled with fusion or arthroplasty. There is a rapidly-emerging research effort to fill this treatment gap with intradiscal therapies that can be delivered minimally-invasively via fluoroscopically guided injection without altering the normal anatomy of the affected vertebral motion segment...
2024: Journal of Pain Research
https://read.qxmd.com/read/38524005/navigating-the-therapeutic-landscape-a-comprehensive-review-of-platelet-rich-plasma-and-bone-marrow-aspirate-concentrate-in-knee-osteoarthritis
#19
REVIEW
Prashanth Balusani, Sandeep Shrivastava, Aditya Pundkar, Prathamesh Kale
This comprehensive review provides an in-depth analysis of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) as potential treatments for knee osteoarthritis. It explores their mechanisms of action, clinical efficacy, safety considerations, and the importance of personalised treatment approaches. The review highlights promising findings regarding the ability of PRP and BMAC to alleviate symptoms, improve joint function, and potentially slow disease progression. It emphasises the need for further research into long-term outcomes, direct comparative studies, protocol standardisation, biomarker identification, and cost-effectiveness assessments to enhance clinical practice...
February 2024: Curēus
https://read.qxmd.com/read/38523475/semi-bone-tunnel-technique-using-double-row-suture-bridge-combined-with-platelet-rich-plasma-hydrogel-for-rotator-cuff-repair-in-a-rabbit-model
#20
JOURNAL ARTICLE
Shengqiang Zeng, Jiacheng Sun, Bo Qin, Yang Liu, Gang Liu, Kai Deng, Yiran Yin, Dingsu Bao
BACKGROUND: The approach to managing the footprint area and reconstructing the tendon-bone interface (TBI) is critical for optimal healing. PURPOSE: To evaluate the outcomes of the semi-bone tunnel (SBT) technique using a double-row suture bridge combined with platelet-rich plasma (PRP) hydrogel for rotator cuff repair in a rabbit model. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 48 New Zealand White rabbits were divided into 4 groups...
March 25, 2024: American Journal of Sports Medicine
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