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exosome microRNA

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https://www.readbyqxmd.com/read/29243842/exosomes-secreted-by-hypoxic-cardiosphere-derived-cells-enhance-tube-formation-and-increase-pro-angiogenic-mirna
#1
Helia Namazi, Elham Mohit, Iman Namazi, Sarah Rajabi, Azam Samadian, Ensiyeh Hajizadeh-Saffar, Nasser Aghdami, Hossein Baharvand
Exosomes are required for the regenerative effects of human cardiosphere-derived cells (CDCs). Studies show that they mimic the cardioprotective benefits of CDCs in rodents and porcine myocardial infarction (MI) models. Hypoxic preconditioning of stem cells increases the cardioprotective effects of exosomes in MI models by enhancing angiogenesis. Several exosomal microRNAs (miRNAs) up-regulate in response to hypoxia and play a role in cardioprotective and pro-angiogenic effects. In this study, we have demonstrated that human CDCs secreted exosomes under hypoxic conditions (1% O2 for 2 days) enhanced tube formation by human umbilical vein endothelial cells (HUVECs) at a concentration of 25 μg/ml...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243807/microrna-as-a-systemic-intervention-in-the-specific-breast-cancer-subtypes-with-c-myc-impacts-introducing-subtype-based-appraisal-tool
#2
REVIEW
Vida Pourteimoor, Mahdi Paryan, Samira Mohammadi-Yeganeh
Breast cancer is indisputably a heterogeneous disease, in which a formidable combination of definitely dis-regulated C-MYC and microRNA (miRNA) profiles along with other factors are responsible to generate a specific type of breast cancer. C-MYC as a master regulator of more than 20,000 genes can modify the expression of genes underlying to perform diverse conflicting functional frameworks. The functional spectra of miRNA in the new areas of the evolution of cell behaviors are identified. Here, we endeavor to summarize some recent advances of miRNA applications that can be recruited as combinatorial targeted therapy for patients with breast cancer...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#3
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240249/exosomal-mir-6803-5p-as-potential-diagnostic-and-prognostic-marker-in-colorectal-cancer
#4
Shushan Yan, Ye Jiang, Caihong Liang, Chengwen Jin, Quanhong Duan, Donghua Xu, Lu Yang, Xiaoyu Zhang, Bin Ren, Peng Jin
Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were determined by microarray analysis and verified by quantitative real-time PCR (qRT-PCR). Outcomes of overall survival (OS) and disease-free survival (DFS) of CRC patients were estimated by Kaplan-Meier analysis...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236313/micrornas-and-exosomes-in-depression-potential-diagnostic-biomarkers
#5
Jahanshir Tavakolizadeh, Kambiz Roshanaei, Arash Salmaninejad, Reza Yari, Javid Sadri Nahand, Hoda Khoshdel Sarkarizi, Seyed Mojtaba Mousavi, Reza Salarinia, Majid Rahmati, Seyed Farshid Mousavi, Ryan Mokhtari, Hamed Mirzaei
Depression is known as one of important psychiatric disorders which could be associated with disability among various populations. Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV) and international statistical classification of diseases and related health problems (ICD-10) could be used as subjective diagnostic schemes for identification of mental disorders such as depression. Utilization of subjective diagnostic schemes are associated with limitations. Hence, it seems that employing of new diagnosis platforms is required...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231896/differential-expression-of-serum-micrornas-supports-cd4%C3%A2-%C2%BA-t-cell-differentiation-into-th2-th17-cells-in-severe-equine-asthma
#6
Alicja Pacholewska, Matthias F Kraft, Vincent Gerber, Vidhya Jagannathan
MicroRNAs (miRNAs) regulate post-transcriptional gene expression and may be exported from cells via exosomes or in partnership with RNA-binding proteins. MiRNAs in body fluids can act in a hormone-like manner and play important roles in disease initiation and progression. Hence, miRNAs are promising candidates as biomarkers. To identify serum miRNA biomarkers in the equine model of asthma we investigated small RNA derived from the serum of 34 control and 37 asthmatic horses. These samples were used for next generation sequencing, novel miRNA identification and differential miRNA expression analysis...
December 12, 2017: Genes
https://www.readbyqxmd.com/read/29230197/exosome-mediated-genetic-information-transfer-a-missing-piece-of-osteoblast-osteoclast-communication-puzzle
#7
Pengbin Yin, Houchen Lv, Yi Li, Yuan Deng, Licheng Zhang, Peifu Tang
The skeletal system functions and maintains itself based on communication between cells of diverse origins, especially between osteoblasts (OBs) and osteoclasts (OCs), accounting for bone formation and resorption, respectively. Previously, protein-level information exchange has been the research focus, and this has been discussed in detail. The regulative effects of microRNAs (miRNAs) on OB and OC ignite the question as to whether genetic information could be transferred between bone cells. Exosomes, extracellular membrane vesicles 30-100 nm in diameter, have recently been demonstrated to transfer functional proteins, mRNAs, and miRNAs, and serve as mediators of intercellular communication...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29227551/high-purity-isolation-and-sensitive-quantification-of-extracellular-vesicles-using-affinity-to-tim4
#8
Takeshi Yoshida, Takamasa Ishidome, Rikinari Hanayama
Almost all types of cells secrete extracellular vesicles (EVs), including exosomes and microvesicles. EVs carry various proteins, lipids, mRNAs, and microRNAs, and may participate in many aspects of physiological and pathophysiological processes. Various studies are currently being conducted to develop therapeutic and diagnostic methods targeting or utilizing EVs. Therefore, developing ideal methods for isolating and quantifying EVs is an active area of research. EVs express phosphatidylserine on their outer lipid bilayer...
December 11, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/29223394/islet-%C3%AE-cell-an-endocrine-cell-secreting-mirnas
#9
Aisen Zhang, Dameng Li, Yucheng Liu, Jing Li, Yujing Zhang, Chen-Yu Zhang
The pancreas is an important endocrine organ. Pancreatic beta (β) cells secrete insulin to regulate the metabolism of glucose and maintain the stability of blood glucose. MicroRNAs (miRNAs), small (20-25 nt) non-coding RNA molecules, function in target gene silencing through post-transcriptional patterns, and multiple miRNAs regulate insulin secretion, insulin signaling pathways in pancreatic β cells and islet activity. In recent years, it has been found that many types of cells can secrete regulatory miRNA, but whether islet cells can secrete miRNA has not been clarified yet...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29222068/foetoplacental-communication-via-extracellular-vesicles-in-normal-pregnancy-and-preeclampsia
#10
REVIEW
Delia I Chiarello, Rocío Salsoso, Fernando Toledo, Alfonso Mate, Carmen M Vázquez, Luis Sobrevia
Intercellular communication is a critical process in biological mechanisms. During pregnancy foetoplacental tissues release a heterogeneous group of extracellular vesicles (EVs) that include exosomes, microvesicles, apoptotic bodies, and syncytial nuclear aggregates. These vesicles contain a complex cargo (proteins, DNA, mRNA transcripts, microRNAs, noncoding RNA, lipids, and other molecules) that actively participate in the maternal-foetal communication by modulating different processes during gestation for a successful foetal development...
December 5, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29221571/micrornas-milk-s-epigenetic-regulators
#11
REVIEW
Bodo C Melnik, Gerd Schmitz
Our perception of milk has changed from a "simple food" to a highly sophisticated maternal-neonatal nutrient and communication system orchestrating early programming of the infant. Milk miRNAs delivered by exosomes and milk fat globules derived from mammary gland epithelial cells play a key role in this process. Exosomes resist the harsh intestinal environment, are taken up by intestinal cells via endocytosis, and reach the systemic circulation of the milk recipient. The most abundant miRNA found in exosomes and milk fat globules of human and cow's milk, miRNA-148a, attenuates the expression of DNA methyltransferase 1, which is critically involved in epigenetic regulation...
August 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29219189/breast-cancer-diagnosis-imaging-techniques-and-biochemical-markers
#12
REVIEW
Seyed Hamed Jafari, Zahra Saadatpour, Arash Salmaninejad, Fatemeh Momeni, Mojgan Mokhtari, Javid Sadri Nahand, Majid Rahmati, Hamed Mirzaei, Mojtaba Kianmehr
Breast cancer is a complex disease which is found as the second cause of cancer-associated death among women. Accumulating of evidence indicated that various factors (i.e. gentical and envirmental factors) could be associated with initiation and progression of breast cancer. Diagnosis of breast cancer patients in early stages is one of important aspects of breast cancer treatment. Among of various diagnosis platforms, imaging techniques are main diagnosis approaches which could provide valuable data on patients with breast cancer...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29218268/blood-based-tumor-biomarkers-in-lung-cancer-for-detection-and-treatment
#13
REVIEW
Hirva Mamdani, Shahid Ahmed, Samantha Armstrong, Tony Mok, Shadia I Jalal
The therapeutic landscape of lung cancer has expanded significantly over the past decade. Advancements in molecularly targeted therapies, strategies to discover and treat resistance mutations, and development of personalized cancer treatments in the context of tumor heterogeneity and dynamic tumor biology have made it imperative to obtain tumor samples on several different occasions through the course of patient treatment. While this approach is critical to the delivery of optimal cancer treatment, it is fraught with a number of barriers including the need for invasive procedures with associated complications, access to limited amount of tissue, logistical delays in obtaining the biopsy, high healthcare cost, and in many cases inability to obtain tissue because of technically difficult location of the tumor...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29216623/exosomal-microrna-mir-1246-promotes-cell-proliferation-invasion-and-drug-resistance-by-targeting-ccng2-in-breast-cancer
#14
Xiu Juan Li, Zhao Jun Ren, Jin Hai Tang, Qiao Yu
BACKGROUND/AIMS: Treatment of breast cancer remains a clinical challenge. This study aims to validate exosomal microRNA-1246 (miR-1246) as a serum biomarker for breast cancer and understand the underlying mechanism in breast cancer progression. METHODS: The expression levels of endogenous and exosomal miRNAs were examined by real time PCR, and the expression level of the target protein was detected by western blot. Scanning electron and confocal microscopy were used to characterize exosomes and to study their uptake and transfer...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29212270/exosomal-mir-141-3p-regulates-osteoblast-activity-to-promote-the-osteoblastic-metastasis-of-prostate-cancer
#15
Yun Ye, Su-Liang Li, Yue-Yun Ma, Yan-Jun Diao, Liu Yang, Ming-Quan Su, Zhuo Li, Yang Ji, Juan Wang, Lin Lei, Wei-Xiao Fan, La-Xiu Li, Yi Xu, Xiao-Ke Hao
Exosomes from cancer cells, which contain microRNA and reach metastasis loci prior to cancer cells, stimulate the formation of a metastatic microenvironment. Previous studies have shown that exosomal miR-141-3p is associated with metastatic prostate cancer (PCa). However, the role and regulatory mechanism of miR-141-3p in the microenvironment of bone metastases require further study. In this study, we performed a series of experiments in vivo and in vitro to determine whether exosomal miR-141-3p from MDA PCa 2b cells regulates osteoblast activity to promote osteoblastic metastasis...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212193/microrna-expression-profiling-in-exosomes-derived-from-gastric-cancer-stem-like-cells
#16
Zhan-Peng Sun, An-Qi Li, Wen-Huan Jia, Sen Ye, Grace Van Eps, Jian-Min Yu, Wei-Jun Yang
Cancer stem-like cells (CSCs) have been identified as the initial cell in formation of cancer. Quiescent CSCs can "hide out" from traditional cancer therapy which may produce an initial response but are often unsuccessful in curing patients. Thus, levels of CSC in patients may be used as an indicator to measure the chance of recurrence of cancer after therapy. The goals of our work are to develop specific exosomal miRNA clusters for gastric CSCs that can potentially predict which patients are at high risk for developing gastric cancer (GC) in order to diagnose GC at an early stage...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208613/do-skeletal-muscle-secreted-factors-influence-the-function-of-pancreatic-beta-cells
#17
Jonathan P Barlow, Thomas P J Solomon
Skeletal muscle is an endocrine organ that secretes a variety of compounds including proteins (myokines), metabolites, microRNAs (miRNAs) and exosomes. Many of which are regulated by exercise and play important roles in endocrine signaling. Inter-organ communication via muscle-secreted factors therefore provides a novel area for investigation and implicates the importance of skeletal muscle in the pathophysiology of metabolic diseases such as type 2 diabetes (T2D). Given that underlying molecular mechanisms of T2D is subject of ongoing research, in light of new evidence, it is probable that inter-organ crosstalk between skeletal muscle and pancreatic beta-cells (β-cells) plays an important part...
December 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29206292/microrna-6869-5p-acts-as-a-tumor-suppressor-via-targeting-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-in-colorectal-cancer
#18
Shushan Yan, Zengfang Wang, Quanhong Duan, Changcheng Wang, Donghua Xu
Many studies have implicated that microRNAs (miRNAs), as non-coding RNAs, play important roles in the development and progression of colorectal cancer (CRC). However, little is known about the role of a newly identified miRNA, miR-6869-5p, in CRC. We aim to investigate the modifying effects and underlying mechanisms of miR-6869-5 in colorectal carcinogenesis and progression. Significantly reduced levels of miR-6869-5p were observed in both serum exosomes tumor tissue samples from patients with CRC. The prediction of targets of miR-6869-5p in databases of targetscan, microRNA...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29202614/liquid-biopsies-in-gastrointestinal-malignancies-when-is-the-big-day
#19
Anthony Lopez, Kazuto Harada, Dilsa Mizrak Kaya, Xiaochuan Dong, Shumei Song, Jaffer A Ajani
Tumor tissue sample is currently the gold standard for diagnosing gastrointestinal cancers, but also for genomic/immune component analyses that can help in the selection of therapy. However, this approach of studying a 'representative' sample of the tumor does not address inherent heterogeneity. Liquid biopsies, mainly represented by circulating tumor cells, circulating tumor DNA, tumor exosomes, and microRNAs, have the potential to assess various biomarkers for early detection of cancer, carrying out genomic/immune profiling for not only selection of appropriate therapy but also to monitor effect of therapy...
December 4, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29200389/-circulating-exosomal-microrna-as-biomarkers-in-mutiple-myeloma
#20
Salomon Manier, Xavier Leleu, Hervé Avet-Loiseau
No abstract text is available yet for this article.
November 2017: Médecine Sciences: M/S
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