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https://www.readbyqxmd.com/read/28726055/an-igrt-margin-concept-for-pelvic-lymph-nodes-in-high-risk-prostate-cancer
#1
M Groher, P Kopp, M Drerup, H Deutschmann, F Sedlmayer, Frank Wolf
PURPOSE: Gold-marker-based image-guided radiation therapy (IGRT) of the prostate allows to correct for inter- and intrafraction motion and therefore to safely reduce margins for the prostate planning target volume (PTV). However, pelvic PTVs, when coadministered in a single plan (registered to gold markers [GM]), require reassessment of the margin concept since prostate movement is independent from the pelvic bony anatomy to which the lymphatics are usually referenced to. METHODS: We have therefore revisited prostate translational movement relative to the bony anatomy to obtain adequate margins for the pelvic PTVs compensating mismatch resulting from referencing pelvic target volumes to GMs in the prostate...
July 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28712277/moderate-hypofractionated-image-guided-thoracic-radiotherapy-for-locally-advanced-node-positive-non-small-cell-lung-cancer-patients-with-very-limited-lung-function-a-case-report
#2
Farkhad Manapov, Olarn Roengvoraphoj, Minglun Li, Chukwuka Eze
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28681448/an-analysis-of-the-arccheck-mr-diode-array-s-performance-for-viewray-quality-assurance
#3
Steven T Ellefson, Wesley S Culberson, Bryan P Bednarz, Larry A DeWerd, John E Bayouth
The ArcCHECK-MR diode array utilizes a correction system with a virtual inclinometer to correct the angular response dependencies of the diodes. However, this correction system cannot be applied to measurements on the ViewRay MR-IGRT system due to the virtual inclinometer's incompatibility with the ViewRay's multiple simultaneous beams. Additionally, the ArcCHECK's current correction factors were determined without magnetic field effects taken into account. In the course of performing ViewRay IMRT quality assurance with the ArcCHECK, measurements were observed to be consistently higher than the ViewRay TPS predictions...
July 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28675492/development-of-patient-controlled-respiratory-gating-system-based-on-visual-guidance-for-magnetic-resonance-image-guided-radiation-therapy
#4
Jung-In Kim, Hanyoung Lee, Hong-Gyun Wu, Eui Kyu Chie, Hyun-Cheol Kang, Jong Min Park
PURPOSE: The aim of this study is to develop a visual guidance patient-controlled (VG-PC) respiratory gating system for respiratory-gated magnetic-resonance image-guided radiation therapy (MR-IGRT) and to evaluate the performance of the developed system. METHODS: The near-real-time cine planar MR image of a patient acquired during treatment was transmitted to a beam projector in the treatment room through an optical fiber cable. The beam projector projected the cine MR images inside the bore of the ViewRay system in order to be visible to a patient during treatment...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28649749/the-more-igrt-systems-the-merrier
#5
EDITORIAL
Baozhou Sun, Jenghwa Chang, Yi Rong
No abstract text is available yet for this article.
June 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28647449/igrt-and-motion-management-during-lung-sbrt-delivery
#6
REVIEW
Vincent Caillet, Jeremy T Booth, Paul Keall
Patient motion can cause misalignment of the tumour and toxicities to the healthy lung tissue during lung stereotactic body radiation therapy (SBRT). Any deviations from the reference setup can miss the target and have acute toxic effects on the patient with consequences onto its quality of life and survival outcomes. Correction for motion, either immediately prior to treatment or intra-treatment, can be realized with image-guided radiation therapy (IGRT) and motion management devices. The use of these techniques has demonstrated the feasibility of integrating complex technology with clinical linear accelerator to provide a higher standard of care for the patients and increase their quality of life...
June 21, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28640871/nomogram-to-predict-rectal-toxicity-following-prostate-cancer-radiotherapy
#7
Jean-Bernard Delobel, Khemara Gnep, Juan David Ospina, Véronique Beckendorf, Ciprian Chira, Jian Zhu, Alberto Bossi, Taha Messai, Oscar Acosta, Joël Castelli, Renaud de Crevoisier
BACKGROUND: To identify predictors of acute and late rectal toxicity following prostate cancer radiotherapy (RT), while integrating the potential impact of RT technique, dose escalation, and moderate hypofractionation, thus enabling us to generate a nomogram for individual prediction. METHODS: In total, 972 patients underwent RT for localized prostate cancer, to a total dose of 70 Gy or 80 Gy, using two different fractionations (2 Gy or 2.5 Gy/day), by means of several RT techniques (3D conformal RT [3DCRT], intensity-modulated RT [IMRT], or image-guided RT [IGRT])...
2017: PloS One
https://www.readbyqxmd.com/read/28637483/analyzing-human-decisions-in-igrt-of-head-and-neck-cancer-patients-to-teach-image-registration-algorithms-what-experts-know
#8
Eva Maria Stoiber, Nina Bougatf, Hendrik Teske, Christian Bierstedt, Dieter Oetzel, Jürgen Debus, Rolf Bendl, Kristina Giske
BACKGROUND: In IGRT of deformable head-and-neck anatomy, patient setup corrections are derived by rigid registration methods. In practice, experienced radiation therapists often correct the resulting vectors, thus indicating a different prioritization of alignment of local structures. Purpose of this study is to transfer the knowledge experts apply when correcting the automatically generated result (pre-match) to automated registration. METHODS: Datasets of 25 head-and-neck-cancer patients with daily CBCTs and corresponding approved setup correction vectors were analyzed...
June 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28612288/magnetic-resonance-image-guidance-in-external-beam-radiation-therapy-planning-and-delivery
#9
REVIEW
Ilamurugu Arivarasan, Chandrasekaran Anuradha, Shanmuga Subramanian, Ayyalusamy Anantharaman, Velayudham Ramasubramanian
The use of magnetic resonance (MR) imaging in radiation oncology is improving dramatically. This review article discusses the necessity of image guidance and how MR finds a significant place in radiotherapy planning and delivery. The challenges to and current solutions for an in-house MR simulation, dedicated MR simulator, estimation of electron density using MR image sets and development of MR-compatible treatment planning systems are presented. This article also reviews the feasibility, advantages and limitations of MR image-guided radiation therapy (MR-IGRT) and its drive toward the integration of radiation beams with MR technology...
June 13, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28586983/igrt-for-lung-sbrt-mvct-versus-kv-cbct
#10
G Baran, T Bossenberger, J W Burmeister, P A Paximadis
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28574131/surprising-complete-response-of-intramedullary-spinal-cord-metastasis-from-breast-cancer-a-case-report-and-literature-review
#11
Dario Aiello, Rosario Mazzola, Fabiana Gregucci, Francesco Ricchetti, Niccolò Giaj Levra, Luigi Romano, Giovanni Carbognin, Matteo Salgarello, Alberto Beltramello, Filippo Alongi
PURPOSE: Intramedullary spinal cord metastases (ISCM) are considered rare but their incidence is rising. Most ISCM cases are recognized to occur in patients with stage IV lung cancer or breast cancer (BC). METHODS: We report a rare case of cervical BC-ISCM in 60-year-old woman, documented by magnetic resonance imaging and positron emission tomography-computed tomography and treated with volumetric modulated arc therapy with daily image-guided radiation therapy (VMAT/IGRT)...
May 29, 2017: Tumori
https://www.readbyqxmd.com/read/28508846/assessment-of-three-dimensional-setup-errors-in-image-guided-pelvic-radiotherapy-for-uterine-and-cervical-cancer-using-kilovoltage-cone-beam-computed-tomography-and-its-effect-on-planning-target-volume-margins
#12
Nidhi Patni, Nagarjuna Burela, Rajesh Pasricha, Jaishree Goyal, Tej Prakash Soni, T Senthil Kumar, T Natarajan
PURPOSE: To achieve the best possible therapeutic ratio using high-precision techniques (image-guided radiation therapy/volumetric modulated arc therapy [IGRT/VMAT]) of external beam radiation therapy in cases of carcinoma cervix using kilovoltage cone-beam computed tomography (kV-CBCT). MATERIALS AND METHODS: One hundred and five patients of gynecological malignancies who were treated with IGRT (IGRT/VMAT) were included in the study. CBCT was done once a week for intensity-modulated radiation therapy and daily in IGRT/VMAT...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28479875/evaluation-of-cone-beam-computed-tomography-image-quality-assurance-for-vero4drt-system
#13
Hideharu Miura, Shuichi Ozawa, Masahiro Hayata, Shintarou Tsuda, Tsubasa Enosaki, Kiyoshi Yamada, Yasushi Nagata
We report the characteristics of quality assurance (QA) image for Vero4DRT system with a kilo-voltage (kV) cone-beam computed tomography (CBCT) capability to perform image-guided radiation therapy (IGRT). To acquire a set of CBCT, the kV source is rotated either 215° clockwise (CW) (tube 1 from 5° to 220° and tube 2 from 275° to 130°) or counterclockwise (CCW) (tube 1 from 85° to 230° and tube 2 from 355° to 140°). Image geometry, image uniformity, high/low contrast resolutions, and contrast linearity were measured with a Catphan 504 CT phantom (The Phantom Laboratory, NY)...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28466155/dosimetric-implications-of-inter-and-intrafractional-prostate-positioning-errors-during-tomotherapy-comparison-of-gold-marker-based-registrations-with-native-mvct
#14
Peter Wust, Marc Joswig, Reinhold Graf, Dirk Böhmer, Marcus Beck, Thomasz Barelkowski, Volker Budach, Pirus Ghadjar
INTRODUCTION: For high-dose radiation therapy (RT) of prostate cancer, image-guided (IGRT) and intensity-modulated RT (IMRT) approaches are standard. Less is known regarding comparisons of different IGRT techniques and the resulting residual errors, as well as regarding their influences on dose distributions. PATIENTS AND METHODS: A total of 58 patients who received tomotherapy-based RT up to 84 Gy for high-risk prostate cancer underwent IGRT based either on daily megavoltage CT (MVCT) alone (n = 43) or the additional use of gold markers (n = 15) under routine conditions...
May 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28464739/magnetic-resonance-only-workflow-and-validation-of-dose-calculations-for-radiotherapy-of-prostate-cancer
#15
Rasmus L Christiansen, Henrik R Jensen, Carsten Brink
BACKGROUND: Current state of the art radiotherapy planning of prostate cancer utilises magnetic resonance (MR) for soft tissue delineation and computed tomography (CT) to provide an electron density map for dose calculation. This dual scan workflow is prone to setup and registration error. This study evaluates the feasibility of an MR-only workflow and the validity of dose calculation from an MR derived pseudo CT. MATERIAL AND METHODS: Thirty prostate cancer patients were CT and MR scanned...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28453537/an-efficient-and-robust-mri-guided-radiotherapy-planning-approach-for-targeting-abdominal-organs-and-tumours-in-the-mouse
#16
Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart
INTRODUCTION: Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to abdominal targets in the mouse. METHODS: A multimodality cradle was developed for providing subject immobilisation and its performance was evaluated. Whilst CT was still used for dose calculations, target identification was based on MRI...
2017: PloS One
https://www.readbyqxmd.com/read/28439497/study-of-recombinant-human-interleukin-12-for-treatment-of-complications-after-radiotherapy-for-tumor-patients
#17
Na Guo, Wen-Qin Wang, Xiao-Jing Gong, Lei Gao, Li-Rong Yang, Wei-Na Yu, Hong-Yu Shen, Ling-Qin Wan, Xi-Feng Jia, Yi-Shan Wang, Yi Zhao
AIM: To evaluate the treatment effects of recombinant human interleukin-12 (rhIL-12) on radiotherapy complications, such as severe myelosuppression or pancytopenia, the decline or imbalance of immune function, etc. METHODS: The patients received high-dose and short-course precise radiotherapy, such as Cyber knife and image-guided radiotherapy (IGRT), which can cause myelosuppression or pancytopenia and immune function decline within a short time. One-hundred subjects were enrolled in the study, and 50 were randomized to a treatment group which used rhIL-12 and 50 were randomized to a control group which used symptomatic and supportive therapy after radiotherapy...
April 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28437010/technical-note-comparison-of-peripheral-patient-dose-from-mr-guided-60-co-therapy-and-6-mv-linear-accelerator-igrt
#18
Pascal Hauri, Roger A Hälg, Uwe Schneider
PURPOSE: The use of X-ray imaging in radiation therapy can give a substantial dose to the patient. A Cobalt machine combined with an magnetic resonance imaging (MRI) was recently introduced to clinical work. One positive aspect of using non-ionizing imaging devices is the reduction of the patient exposure. The purpose of this study was to quantify the difference in out-of-field dose to the patient between the image guided radiation therapy (IGRT) treatment applied with a linear accelerator with cone beam CT (CBCT) equipment and a Cobalt machine combined with an MRI...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28434799/improved-outcomes-with-dose-escalation-in-localized-prostate-cancer-treated-with-precision-image-guided-radiotherapy
#19
Hamid Raziee, Fabio Y Moraes, Jure Murgic, Melvin L K Chua, Melania Pintilie, Peter Chung, Cynthia Ménard, Andrew Bayley, Mary Gospodarowicz, Padraig Warde, Tim Craig, Charles Catton, Robert G Bristow, David A Jaffray, Alejandro Berlin
BACKGROUND AND PURPOSE: Dose-escalated radiotherapy (DE) improves outcomes in localized prostate cancer (PCa). The impact of DE in the context of image-guided radiotherapy (IGRT) remains unknown. Herein, we determined outcomes of three sequential cohorts treated with progressive DE-IGRT. MATERIALS AND METHODS: We analyzed data from 1998 to 2012. Patients treated with radical radiotherapy were included, with three sequential institutional schedules: (A) 75.6Gy, (B) 79...
June 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28428474/evaluation-of-absorbed-dose-for-cbct-in-image-guided-radiation-therapy-comparison-of-each-devices-and-facilities
#20
Yumiko Kitazato, Noriyuki Kuga, Katsutoshi Shirieda, Masahiro Enzaki, Yuji Nakaguchi, Yoshinobu Shimohigashi, Toshihisa Kawasaki, Masahiko Toyoda, Daisuke Kawahara, Fujio Araki, Shinji Kawamura
Recently, intensity-modulated radiation therapy (IMRT) is used worldwide, highly accurate verification of the location using image-guided radiation therapy (IGRT) has become critical. However, the use of cone-beam computed tomography (CBCT) to ascertain the location each time raises concerns about its influence on radiotherapy dosage and increased radiation exposure. The purpose of this study was to measure the absorbed dose using nine kilovoltage (kV) devices and two megavoltage (MV) devices (total 11 devices) at eight facilities, compare the absorbed dose among the devices, and assess the characteristics of the respective devices to ensure optimal clinical operation...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
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