Read by QxMD icon Read


Yu Zhu, Yingxin Gu, Shichong Qiao, Linyi Zhou, Junyu Shi, Hongchang Lai
Microorganisms are frequently introduced to dental implants during surgery and start the race for the surface with host cells before osseointegration occurs. The aim of the study was to endow implant surfaces with biological functions that reliably select cells over microbes. Nano-structured tantalum (Ta) has exhibited excellent compatibility. Thus, nano-structured Ta films were deposited on the sand-blasted, large grit and acid-etched (SLA) titanium by the magnetron sputtering method, thus forming hierarchical micro/nanostructured surfaces...
October 26, 2016: Journal of Biomedical Materials Research. Part A
Adewole S Adamson, Elizabeth A Suarez, April R Gorman
Importance: Prescription underuse is associated with poorer clinical outcomes. A significant proportion of underuse is owing to primary nonadherence, defined as the rate at which patients fail to fill and pick up new prescriptions. Although electronic prescribing increases coordination of care and decreases errors, its effect on primary nonadherence is less certain. Objectives: To analyze factors associated with primary nonadherence to dermatologic medications and study whether electronic prescribing affects rates of primary nonadherence...
October 26, 2016: JAMA Dermatology
Paolo Fusar-Poli, Grazia Rutigliano, Daniel Stahl, André Schmidt, Valentina Ramella-Cravaro, Shetty Hitesh, Philip McGuire
Importance: Pretest risk estimation is routinely used in clinical medicine to inform further diagnostic testing in individuals with suspected diseases. To our knowledge, the overall characteristics and specific determinants of pretest risk of psychosis onset in individuals undergoing clinical high risk (CHR) assessment are unknown. Objectives: To investigate the characteristics and determinants of pretest risk of psychosis onset in individuals undergoing CHR assessment and to develop and externally validate a pretest risk stratification model...
October 26, 2016: JAMA Psychiatry
Deborah Carvalho Malta, Sheila Rizzato Stopa, Rogerio Canuto, Nayara Lopes Gomes, Vera Lúcia Ferreira Mendes, Bárbara Niegia Garcia de Goulart, Lenildo de Moura
Objective: To describe the self-reported prevalence of intellectual disability, physical, hearing and visual, according to sociodemographic variables, degree of limitation and frequency of rehabilitation service use. Methods: Data from the National Health Survey, a population survey. the self-reported prevalence of physical, mental, visual and hearing were calculated and their 95% confidence intervals, stratified by sex, age, race / color, for Brazil, place of residence and Major Regions...
October 2016: Ciência & Saúde Coletiva
Brian Dodge, Debby Herbenick, M Reuel Friedman, Vanessa Schick, Tsung-Chieh Jane Fu, Wendy Bostwick, Elizabeth Bartelt, Miguel Muñoz-Laboy, David Pletta, Michael Reece, Theo G M Sandfort
: As bisexual individuals in the United States (U.S.) face significant health disparities, researchers have posited that these differences may be fueled, at least in part, by negative attitudes, prejudice, stigma, and discrimination toward bisexual individuals from heterosexual and gay/lesbian individuals. Previous studies of individual and social attitudes toward bisexual men and women have been conducted almost exclusively with convenience samples, with limited generalizability to the broader U...
2016: PloS One
Uduak U Andy, Camille P Vaughan, Kathryn L Burgio, Foluke M Alli, Patricia S Goode, Alayne D Markland
OBJECTIVES: To estimate the prevalence of constipation, fecal incontinence (FI), and combined symptoms and to identify shared factors associated with bowel symptoms in older U.S. men and women DESIGN: Population-based cross-sectional study. SETTING: National Health and Nutrition Examination Survey (2005-2010). PARTICIPANTS: Women and men aged 50 and older. MEASUREMENTS: Constipation was defined as hard stool consistency on the validated Bristol Stool Form Scale or stool frequency of fewer than three bowel movements per week...
October 26, 2016: Journal of the American Geriatrics Society
Arno K Kumagai, Brittani Jackson, Saleem Razack
Learning the societal roles and responsibilities of the physician may involve difficult, contentious conversations about topics such as race, gender, sexual orientation, and class, as well as violence, inequities, sexual assault, and child abuse. If not done well, these discussions may be deeply traumatizing to learners for whom these subjects "cut close to the bone." Equally traumatizing is exposure to injustice and mistreatment, as well as to the sights, sounds, and smells of suffering and pain in the clinical years...
October 25, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Lydiane Gaborieau, Gregory G Brown
BACKGROUND: The plant trait of cytoplasmically-inherited male sterility (CMS) and its suppression by nuclear restorer-of-fertility (Rf) genes can be viewed as a genetic arms race between the mitochondrial and nuclear genomes. Most nuclear Rf genes have been shown to encode P-type pentatricopeptide repeat proteins (PPRs). Phylogenetic analysis of P-class PPRs from sequenced plants genomes has shown that Rf-proteins cluster in a distinct clade of P-class PPRs, RFL-PPRs, that display hallmarks of positive evolutionary selection...
October 26, 2016: BMC Genomics
Sheng-Jou Hung, Yi-Lin Chen, Chia-Hung Chu, Chuan-Chun Lee, Wan-Li Chen, Ya-Lan Lin, Ming-Ching Lin, Chung-Liang Ho, Tsunglin Liu
BACKGROUND: T cells and B cells are essential in the adaptive immunity via expressing T cell receptors and immunoglogulins respectively for recognizing antigens. To recognize a wide variety of antigens, a highly diverse repertoire of receptors is generated via complex recombination of the receptor genes. Reasonably, frequencies of the recombination events have been shown to predict immune diseases and provide insights into the development of immunity. The field is further boosted by high-throughput sequencing and several computational tools have been released to analyze the recombined sequences...
October 26, 2016: BMC Bioinformatics
Kathrine Lynn Barnes, Casper G Bendixsen
Farmers are growing older, and fewer new agriculturists are rising to take their place. Concurrently, women and minorities are entering agriculture at an increasing rate. These rates are particularly curious viewed in light of the racialized and gendered nature of agriculture. Slavery and agriculture share strong historical roots with many male slaves performing agricultural labor. So then, why would African American women choose to engage in agriculture in any form? Participant-observation and in-depth interviews with a group of African American women urban farmers in the southeastern United States were asked this question...
October 26, 2016: Journal of Agromedicine
Alison M Stuebe, Karen Bonuck, Reuben Adatorwovor, Todd A Schwartz, Diane C Berry
BACKGROUND: Women with gestational diabetes mellitus (GDM) and their infants are at increased risk of developing metabolic disease; however, longer breastfeeding is associated with a reduction in these risks. We tested an intervention to increase breastfeeding duration among women with GDM. MATERIALS AND METHODS: We conducted a cluster randomized trial to determine the efficacy of a breastfeeding education and support program for women with GDM. Women were enrolled between 22 and 36 weeks of pregnancy and cluster randomized to an experimental lifestyle intervention or wait-list control group...
October 26, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Max S Chiu, Vivek Verma, Nathan R Bennion, Abhijeet R Bhirud, Jinluan Li, Mary E Charlton, Chandrakanth Are, Chi Lin
Large, population-based analyses of rectal squamous cell carcinoma (SCC) have not been previously conducted. We assessed patterns of care, prognostic factors, and outcomes of rectal SCC and adenocarcinoma (AC) in population-based cohorts. Surveillance, Epidemiology, and End Results (SEER) registry searches were performed (1998-2011), producing 42,308 nonmetastatic rectal cancer patients (999 SCC and 41,309 AC). Patient, tumor, and treatment characteristics were compared. Based on risk factors, SCC/AC groups were subdivided into low-, intermediate-, and high-risk groups...
October 26, 2016: Cancer Medicine
Ziwei Zhang, Mingyu Bi, Qi Liu, Jie Yang, Shiwen Xu
Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method...
October 21, 2016: Oncotarget
Christina R Studts, Jodi Polaha, Michiel A van Zyl
OBJECTIVE : Efficient identification and referral to behavioral services are crucial in addressing early-onset disruptive behavior problems. Existing screening instruments for preschoolers are not ideal for pediatric primary care settings serving diverse populations. Eighteen candidate items for a new brief screening instrument were examined to identify those exhibiting measurement bias (i.e., differential item functioning, DIF) by child characteristics. METHOD : Parents/guardians of preschool-aged children (N = 900) from four primary care settings completed two full-length behavioral rating scales...
October 25, 2016: Journal of Pediatric Psychology
Ana Babic, Ying Bao, Zhi Rong Qian, Chen Yuan, Edward L Giovannucci, Hugues Aschard, Peter Kraft, Laufey T Amundadottir, Rachael Z Stolzenberg-Solomon, Vicente Morales-Oyarvide, Kimmie Ng, Meir J Stampfer, Shuji Ogino, Julie E Buring, Howard D Sesso, John Michael Gaziano, Nader Rifai, Michael N Pollak, Matthew L Anderson, Barbara B Cochrane, Juhua Luo, JoAnn E Manson, Charles S Fuchs, Brian Wolpin
Leptin is an adipokine involved in regulating energy balance which has been identified as a potential biological link in development of obesity-associated cancers such as pancreatic cancer. In this prospective, nested case-control study of 470 cases and 1094 controls from five U.S. cohorts, we used conditional logistic regression to evaluate pancreatic cancer risk by prediagnostic plasma leptin, adjusting for race/ethnicity, diabetes, body-mass index, physical activity, plasma C-peptide, adiponectin, and 25-hydroxyvitamin D...
October 25, 2016: Cancer Research
Kimberley P Good, Isabelle A Tourbier, Paul Moberg, Jennifer L Cuzzocreo, Rena J Geckle, David M Yousem, Dzung L Pham, Richard L Doty
It is not known whether lateralized olfactory sensitivity deficits are present in MS.Since projections from the olfactory bulb to the olfactory cortex are largely ipsilateral, and since both functional imaging and psychophysical studies suggest that the right side of the brain may be more involved in olfactory processing than the left, we addressed this issue by administering well-validated tests of odor detection, along with tests of odor identification, to each side of the nose of 73 MS patients and 73 age-, gender-, and race-matched normal controls...
October 22, 2016: Physiology & Behavior
Hui Zhao, Nainan Hei, Yiling Wu, Winston Chan, Xiudong Lei, Carrie Cameron, Shine Chang, Mariana Chavez-MacGregor, Sharon H Giordano
BACKGROUND: The National Surgical Adjuvant Breast and Bowel Project B35 and International Breast Cancer Intervention Studies II Ductal Carcinoma In Situ trials showed similar treatment effects of anastrozole and tamoxifen in reducing cancer recurrence risk among ductal carcinoma in situ (DCIS) patients. Studies have shown low levels of hormone therapy drug initiation for DCIS patients, but the current body of literature lacks information on the 5-year adherence rates for these drugs from population-based studies...
October 25, 2016: Cancer
Kathryn S Carpentier, Nicolle M Esparo, Stephanie J Child, Adam P Geballe
During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway. Consequently, these adaptations may also contribute to the inability of CMVs to cross species barriers. Here, we provide evidence that the evolutionary arms race between the antiviral factor PKR and its CMV antagonist TRS1 has led to extensive differences in the species-specificity of primate CMV TRS1 proteins. Moreover, we identify a single residue in human PKR that when mutated to the amino acid present in African green monkey (Agm) PKR (F489S) is sufficient to confer resistance to HCMVTRS1...
October 2016: PLoS Pathogens
Yang Lu, Scott Friedlander, Steven L Lee
Historically, performing a negative appendectomy (NA) was justified to reduce the incidence of perforation. Furthermore, it is also believed that NA is associated with minimal morbidity and cost. The purpose of this study was to evaluate the frequency, clinical characteristics, and economic implications of NA. We reviewed the inpatient admissions on 274,405 patients who underwent nonincidental appendectomy as their primary procedure from the California State Inpatient Databases (2005-2011). Overall, 96.9 per cent had appendicitis (nonperforated = 73...
October 2016: American Surgeon
Xuan-Binh D Pham, Jerry J Kim, Aaron B Parrish, Cynthia Tom, Ezinne J Ihenachor, David Mina, Christian de Virgilio
Prior studies have shown racial and gender differences with respect to maturation of arteriovenous fistulas. Women and minorities have lower maturation rates for unclear reasons. Small arterial diameter and high brachial artery bifurcation (HBB) are also implicated in reduced maturation rates. We sought to correlate differences in upper extremity arterial anatomy to race and gender. All upper extremity vascular mapping ultrasounds from 2013 to 2014 were retrospectively reviewed. A total of 509 arms in 284 patients were evaluated...
October 2016: American Surgeon
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"