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https://www.readbyqxmd.com/read/29471454/the-impact-of-using-different-reference-populations-on-measurement-of-breast-cancer-related-cognitive-impairment-rates
#1
Jonathan D Clapp, George Luta, Brent J Small, Tim A Ahles, James C Root, Deena Graham, Arti Hurria, Paul B Jacobsen, Heather Jim, Brenna C McDonald, Robert A Stern, Andrew J Saykin, Jeanne S Mandelblatt
Objective: To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates. Methods: Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29470413/electrical-mechanical-monitoring-of-shape-memory-alloy-reinforcing-fibers-obtained-by-pullout-tests-in-sma-cement-composite-materials
#2
Eui-Hyun Kim, Hyunbae Lee, Jae-Hwan Kim, Seung-Muk Bae, Heesu Hwang, Heesun Yang, Eunsoo Choi, Jin-Ha Hwang
Self-healing is an essential property of smart concrete structures. In contrast to other structural metals, shape memory alloys (SMAs) offer two unique effects: shape memory effects, and superelastic effects. Composites composed of SMA wires and conventional cements can overcome the mechanical weaknesses associated with tensile fractures in conventional concretes. Under specialized environments, the material interface between the cementitious component and the SMA materials plays an important role in achieving the enhanced mechanical performance and robustness of the SMA/cement interface...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29469805/c-ebp%C3%AE-drives-interactions-between-human-mait-cells-and-endothelial-cells-that-are-important-for-extravasation
#3
Chang Hoon Lee, Hongwei H Zhang, Satya P Singh, Lily Koo, Juraj Kabat, Hsinyi Tsang, Tej Pratap Singh, Joshua M Farber
Many mediators and regulators of extravasation by bona fide human memory-phenotype T cells remain undefined. Mucosal-associated invariant T (MAIT) cells are innate-like, anti-bacterial cells that we found excelled at crossing inflamed endothelium. They displayed abundant selectin ligands, with high expression of FUT7 and ST3GAL4 , and expressed CCR6, CCR5, and CCR2, which played non-redundant roles in trafficking on activated endothelial cells. MAIT cells selectively expressed CCAAT/enhancer-binding protein delta (C/EBPδ)...
February 22, 2018: ELife
https://www.readbyqxmd.com/read/29469586/fixation-reinstatement-supports-visuospatial-memory-in-older-adults
#4
Jordana S Wynn, Rosanna K Olsen, Malcolm A Binns, Bradley R Buchsbaum, Jennifer D Ryan
Research using eye movement monitoring suggests that recapitulating the pattern of eye movements made during stimulus encoding at subsequent retrieval supports memory by reinstating the spatial layout of the encoded stimulus. In the present study, the authors investigated whether recapitulation of encoding fixations during a poststudy, stimulus-free delay period-an effect that has been previously linked to memory maintenance in younger adults-can support mnemonic performance in older adults. Older adults showed greater delay-period fixation reinstatement than younger adults, and this reinstatement supported age-equivalent performance on a subsequent visuospatial-memory-based change detection task, whereas in younger adults, the performance-enhancing effects of fixation reinstatement increased with task difficulty...
February 22, 2018: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29468869/non-volatile-electric-double-layer-transistor-memory-embedded-with-au-nanoparticles
#5
Jaemok Koo, Jee Hye Yang, Boeun Cho, Hyunwoo Jo, Keun Hyung Lee, Moon Sung Kang
We present non-volatile transistor memory devices that rely on the formation of electric double layer (EDL) at the semiconductor electrolyte interface. The two critical functional components of the device are ion gel electrolyte and gold nanoparticles (NPs). The ion gel electrolyte contains ionic species for EDL formation that allow inducing charges in the semiconductor/electrolyte interface. The gold NPs inserted between the ion gel and the channel layer serve as trapping sites to the induced charges to store the electrical input signals...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29468148/polyamines-bio-molecules-with-diverse-functions-in-plant-and-human-health-and-disease
#6
REVIEW
Avtar K Handa, Tahira Fatima, Autar K Mattoo
Biogenic amines-polyamines (PAs), particularly putrescine, spermidine and spermine are ubiquitous in all living cells. Their indispensable roles in many biochemical and physiological processes are becoming commonly known, including promoters of plant life and differential roles in human health and disease. PAs positively impact cellular functions in plants-exemplified by increasing longevity, reviving physiological memory, enhancing carbon and nitrogen resource allocation/signaling, as well as in plant development and responses to extreme environments...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29467641/propensity-for-bistability-of-bursting-and-silence-in-the-leech-heart-interneuron
#7
Tatiana Dashevskiy, Gennady Cymbalyuk
The coexistence of neuronal activity regimes has been reported under normal and pathological conditions. Such multistability could enhance the flexibility of the nervous system and has many implications for motor control, memory, and decision making. Multistability is commonly promoted by neuromodulation targeting specific membrane ionic currents. Here, we investigated how modulation of different ionic currents could affect the neuronal propensity for bistability. We considered a leech heart interneuron model...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29467328/allograft-dendritic-cell-p40-homodimers-activate-donor-reactive-memory-cd8-t-cells
#8
Hidetoshi Tsuda, Charles A Su, Toshiaki Tanaka, Katayoun Ayasoufi, Booki Min, Anna Valujskikh, Robert L Fairchild
Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior to organ transplantation increase early posttransplant inflammation and negatively impact early graft function and long-term graft outcome. Little is known about the mechanisms enhancing endogenous memory T cell activation to mediate tissue injury within the increased inflammatory environment of allografts subjected to prolonged cold ischemic storage (CIS)...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29466961/a-randomised-trial-to-compare-cognitive-outcome-after-gamma-knife-radiosurgery-versus-whole-brain-radiation-therapy-in-patients-with-multiple-brain-metastases-research-protocol-car-study-b
#9
Wietske C M Schimmel, Eline Verhaak, Patrick E J Hanssens, Karin Gehring, Margriet M Sitskoorn
BACKGROUND: Gamma Knife radiosurgery (GKRS) is increasingly applied in patients with multiple brain metastases and is expected to have less adverse effects in cognitive functioning than whole brain radiation therapy (WBRT). Effective treatment with the least negative cognitive side effects is increasingly becoming important, as more patients with brain metastases live longer due to more and better systemic treatment options. There are no published randomized trials yet directly comparing GKRS to WBRT in patients with multiple brain metastases that include objective neuropsychological testing...
February 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29466726/tet2-rescues-age-related-regenerative-decline-and-enhances-cognitive-function-in-the-adult-mouse-brain
#10
Geraldine Gontier, Manasi Iyer, Jeremy M Shea, Gregor Bieri, Elizabeth G Wheatley, Miguel Ramalho-Santos, Saul A Villeda
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes the production of 5-hydroxymethylcytosine (5hmC), rescues age-related decline in adult neurogenesis and enhances cognition in mice. We detected a decrease in Tet2 expression and 5hmC levels in the aged hippocampus associated with adult neurogenesis...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29466242/mindfulness-and-meditation-treating-cognitive-impairment-and-reducing-stress-in-dementia
#11
Jesse Russell-Williams, Wafa Jaroudi, Tania Perich, Siobhan Hoscheidt, Mohamad El Haj, Ahmed A Moustafa
This study investigates the relationship between mindfulness, meditation, cognition and stress in people with Alzheimer's disease (AD), dementia, mild cognitive impairment and subjective cognitive decline. Accordingly, we explore how the use of meditation as a behavioural intervention can reduce stress and enhance cognition, which in turn ameliorates some dementia symptoms. A narrative review of the literature was conducted with any studies using meditation as an intervention for dementia or dementia-related memory conditions meeting inclusion criteria...
February 21, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29465625/spinal-bromodomain-containing-protein-4-contributes-to-neuropathic-pain-induced-by-hiv-glycoprotein-120-with-morphine-in-rats
#12
Keiya Takahashi, Hyun Yi, Ching-Hang Liu, Shue Liu, Yuta Kashiwagi, Dennis J Patin, Shuanglin Hao
The symptoms of HIV-sensory neuropathy are dominated by neuropathic pain. Recent data show that repeated use of opiates enhances the chronic pain states in HIV patients. Limited attention has so far been devoted to exploring the exact pathogenesis of HIV painful disorder and opiate abuse in vivo, for which there is no effective treatment. Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal domain protein (BET) family and functions as a chromatin 'reader' that binds acetylated lysines in histones in brain neurons to mediate the transcriptional regulation underlying learning and memory...
February 20, 2018: Neuroreport
https://www.readbyqxmd.com/read/29465060/cyclic-fatigue-resistance-of-novel-rotary-files-manufactured-from-different-thermal-treated-nickel-titanium-wires-in-artificial-canals
#13
E Karataşlıoglu, U Aydın, C Yıldırım
Aims: The aim of this in vitro study was to compare the static cyclic fatigue resistance of thermal treated rotary files with a conventional nickel-titanium (NiTi) rotary file. Subjects and Methods: Four groups of 60 rotary files with similar file dimensions, geometries, and motion were selected. Groups were set as HyFlex Group [controlled memory wire (CM-Wire)], ProfileVortex Group (M-Wire), Twisted File Group (R-Phase Wire), and OneShape Group (conventional NiTi wire)] and tested using a custom-made static cyclic fatigue testing apparatus...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29464986/protective-effects-of-thymoquinone-on-d-galactose-and-aluminum-chloride-induced-neurotoxicity-in-rats-biochemical-histological-and-behavioral-changes
#14
Yasmin S Abulfadl, Nabila N El-Maraghy, Amany Ali Eissa Ahmed, Shahira Nofal, Osama A Badary
OBJECTIVES: Thymoquinone (TQ), the main active ingredient in Nigella sativa oil, exhibits various bioactivities. This study aimed to investigate the effect of TQ on neurobehavioral and neuropathological alterations induced by aluminum trichloride (AlCl3 ) and D-galactose (D-gal)-in male rats and to explore the related mechanisms. METHODS: D-gal (60 mg/kg day) and AlCl3 (10 mg/kg day) were given intraperitoneally (i.p.) once daily for 42 days and after 4 weeks TQ was concomitantly administered intragastrically (i...
February 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29464521/remembering-the-place-with-the-tiger-survival-processing-can-enhance-source-memory
#15
Meike Kroneisen, Raoul Bell
Rating the relevance of words for survival in the grasslands of a foreign land often leads to a memory advantage. However, it is as yet unclear whether the survival processing effect generalizes to source memory. Here, we examined whether people have enhanced source memory for the survival context in which an item has been encountered. Participants were asked to make survival-based or moving-based decisions about items prior to a classical source memory test. A multinomial model was used to measure old-new discrimination, source memory, and guessing biases separately...
February 20, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29462212/epstein-barr-virus-nuclear-antigen-ebna-lp-is-essential-for-transforming-na%C3%A3-ve-b-cells-and-facilitates-recruitment-of-transcription-factors-to-the-viral-genome
#16
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of IR1. EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection...
February 20, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29460269/novel-defense-by-metallothionein-induction-against-cognitive-decline-from-amyloid-%C3%AE-1-42-induced-excess-zn-2-to-functional-zn-2-deficiency
#17
Atsushi Takeda, Haruna Tamano, Wakana Hashimoto, Shuhei Kobuchi, Hiroki Suzuki, Taku Murakami, Munekazu Tempaku, Yuta Koike, Paul A Adlard, Ashley I Bush
The role of metallothioneins (MTs) in cognitive decline associated with intracellular Zn2+ dysregulation remains unclear. Here, we report that hippocampal MT induction defends cognitive decline, which was induced by amyloid β1-42 (Aβ1-42 )-mediated excess Zn2+ and functional Zn2+ deficiency. Excess increase in intracellular Zn2+ , which was induced by local injection of Aβ1-42 into the dentate granule cell layer, attenuated in vivo perforant pathway LTP, while the attenuation was rescued by preinjection of MT inducers into the same region...
February 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29460167/alzheimer-disease-detection-from-structural-mr-images-using-fcm-based-weighted-probabilistic-neural-network
#18
Baskar Duraisamy, Jayanthi Venkatraman Shanmugam, Jayanthi Annamalai
An early intervention of Alzheimer's disease (AD) is highly essential due to the fact that this neuro degenerative disease generates major life-threatening issues, especially memory loss among patients in society. Moreover, categorizing NC (Normal Control), MCI (Mild Cognitive Impairment) and AD early in course allows the patients to experience benefits from new treatments. Therefore, it is important to construct a reliable classification technique to discriminate the patients with or without AD from the bio medical imaging modality...
February 19, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29459910/fabrication-of-tough-epoxy-with-shape-memory-effects-by-uv-assisted-direct-ink-write-printing
#19
Kaijuan Chen, Xiao Kuang, Vincent Li, Guozheng Kang, H Jerry Qi
3D printing of epoxy-based shape memory polymers with high mechanical strength, excellent thermal stability and chemical resistance is highly desirable for practical applications. However, thermally cured epoxy in general is difficult to print directly. There have been limited numbers of successes in printing epoxy but they suffer from relatively poor mechanical properties. Here, we present an ultraviolet (UV)-assisted 3D printing of thermally cured epoxy composites with high tensile toughness via a two-stage curing approach...
February 20, 2018: Soft Matter
https://www.readbyqxmd.com/read/29459721/debye-formulas-for-a-relaxing-system-with-memory
#20
Ivo Klik, James McHugh, Roy W Chantrell, Ching-Ray Chang
Rate (master) equations are ubiquitous in statistical physics, yet, to the best of our knowledge, a rate equation with memory has previously never been considered. We write down an integro-differential rate equation for the evolution of a thermally relaxing system with memory. For concreteness we adopt as a model a single-domain magnetic particle driven by a small ac field and derive the modified Debye formulas. For any memory time Θ the in-phase component of the resultant ac susceptibility is positive at small probing frequencies ω, but becomes negative at large ω...
February 19, 2018: Scientific Reports
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