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https://www.readbyqxmd.com/read/28817717/short-report-trpv1-polymorphism-1911-a-g-alters-capsaicin-induced-sensory-changes-in-healthy-subjects
#1
Julia Forstenpointner, Matti Förster, Denisa May, Friederike Hofschulte, Ingolf Cascorbi, Gunnar Wasner, Janne Gierthmühlen, Ralf Baron
BACKGROUND: C-fibers express transient receptor potential (TRP) channels. These high-voltage gated channels function as integrators of different physical stresses (e.g. heat, protons, ATP). Additionally channel activation can be induced by capsaicin. Topically applied, capsaicin elicits burning pain, heat and mechanical hyperalgesia and serves as a human surrogate model for pain. It was suggested that the TRPV1-variant rs8065080 (1911A>G) plays a pivotal role in patients with neuropathic pain syndromes...
2017: PloS One
https://www.readbyqxmd.com/read/28805754/-a-phenomenological-analysis-of-non-suicidal-self-injuries-in-adolescents
#2
O B Levkovskaja, Ju S Shevchenko, L Ju Danilova, V V Grachev
AIM: To perform a phenomenological/clinical/psychopathological analysis of non-suicidal self-injury behavior (NSSI) in adolescents. MATERIAL AND METHODS: The authors studied 155 adolescents, 140 girls and 15 boys, aged 12-17 years, including 111 with self-cutting, 5 with self-burning, 4 with self-beating. Other cases included combined, multiple and other variants of NSSI. RESULTS AND CONCLUSION: NSSI develop more often in female teenagers...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28804804/life-cycle-environmental-impacts-of-bioethanol-production-from-sugarcane-molasses-in-iran
#3
Saeid Shahvarooghi Farahani, Mohammad Amin Asoodar
In recent years, bioethanol from sugarcane molasses has been produced on an industrial scale in Iran. The aim of this study was to evaluate molasses-based bioethanol production from an environmental point of view. Data were collected from Debel Khazai agro-industry situated in southern region of Iran by using face-to-face interviews and annual statistics of 2010 to 2016 (6-year life cycle of sugarcane cultivation). Ten impact categories including abiotic depletion (AD), acidification (AC), eutrophication (EP), global warming potential (GWP), ozone layer depletion (OLD), human toxicity (HT), freshwater aquatic ecotoxicity (FE), marine aquatic ecotoxicity (ME), terrestrial ecotoxicity (TE), and photochemical oxidation (PO) were selected based on CML methodology...
August 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28801148/assessing-and-addressing-the-problem-of-pain-and-distress-during-wound-care-procedures-in-paediatric-patients-with-burns
#4
Marianne J E van der Heijden, Alette de Jong, Heinz Rode, Roux Martinez, Monique van Dijk
OBJECTIVE: While the prevalence of burns in children is highest in low and middle-income countries, most research on burn-related pain intensity and distress is carried out in high-income countries. In this study we assessed pain intensity and distress in paediatric patients with burns undergoing wound care procedures without distraction and parental presence in a South-African children's hospital and sought to identify predictors for the outcomes. METHODS: This observational study, carried out as part of a randomized controlled trial, took place at a burns unit in Cape Town, South Africa and included patients between the ages of 0 and 13 years undergoing their first or second wound care procedure...
August 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28800688/monitoring-of-air-pollution-levels-related-to-charilaos-trikoupis-bridge
#5
D A Sarigiannis, E J Handakas, M Kermenidou, I Zarkadas, A Gotti, P Charisiadis, K Makris, M Manousakas, K Eleftheriadis, S P Karakitsios
Charilaos Trikoupis bridge is the longest cable bridge in Europe that connects Western Greece with the rest of the country. In this study, six air pollution monitoring campaigns (including major regulated air pollutants) were carried out from 2013 to 2015 at both sides of the bridge, located in the urban areas of Rio and Antirrio respectively. Pollution data were statistically analyzed and air quality was characterized using US and European air quality indices. From the overall campaign, it was found that air pollution levels were below the respective regulatory thresholds, but once at the site of Antirrio (26...
August 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28800544/protease-loaded-permeation-enhancer-liposomes-for-treatment-of-skin-fibrosis-arisen-from-second-degree-burn
#6
Kamini Sahu, Monika Kaurav, Ravi Shankar Pandey
Cysteine protease (papain) is a plant derived enzyme and due to its collagenolytic activity has potential in fibrosis reduction. However, a major hurdle in its use as fibrosis reducing agent is to overcome stratum corneum skin barrier via topical application, owing to its hydrophilic and high molecular weight and protein nature which is prone to degradation. The aim of the present study was to develop a penetration enhancer incorporated drug delivery system, i.e. propylene glycol (PG) liposomes, loaded with papain for application in fibrosis therapy...
August 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28798193/the-role-of-vascular-endothelial-growth-factor-b-in-metabolic-homeostasis-current-evidence
#7
Mohammad Ishraq Zafar, Juan Zheng, Wen Kong, Xiaofeng Ye, Luoning Gou, Anita Regmi, Lu-Lu Chen
It has been shown that adipose tissue and skeletal muscles of lean individuals respond to meal-induced hyperinsulinemia by increases in perfusion, the effect not observed in patients with metabolic syndrome. In conditions of hyperglycaemia and hypertriglyceridemia, this insufficient vascularization leads to the liberation of reactive oxygen species, and disruption of nitric oxide synthesis and endothelial signalling responsible for the uptake of circulating fatty acids, whose accumulation in skeletal muscles and adipose tissue is widely associated with impairment of insulin signalling...
August 10, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28797628/refuse-derived-fuel-rdf-production-and-gasification-in-a-pilot-plant-integrated-with-an-otto-cycle-ice-through-aspen-plus%C3%A2-modelling-thermodynamic-and-economic-viability
#8
Albany Milena Lozano Násner, Electo Eduardo Silva Lora, José Carlos Escobar Palacio, Mateus Henrique Rocha, Julian Camilo Restrepo, Osvaldo José Venturini, Albert Ratner
This work deals with the development of a Refuse Derived Fuel (RDF) gasification pilot plant using air as a gasification agent. A downdraft fixed bed reactor is integrated with an Otto cycle Internal Combustion Engine (ICE). Modelling was carried out using the Aspen Plus™ software to predict the ideal operational conditions for maximum efficiency. Thermodynamics package used in the simulation comprised the Non-Random Two-Liquid (NRTL) model and the Hayden-O'Connell (HOC) equation of state. As expected, the results indicated that the Equivalence Ratio (ER) has a direct influence over the gasification temperature and the composition of the Raw Produced Gas (RPG), and effects of ER over the Lower Heating Value (LHV) and Cold Gasification Efficiency (CGE) of the RPG are also discussed...
August 7, 2017: Waste Management
https://www.readbyqxmd.com/read/28794620/spreading-improvements-for-advanced-copd-care-through-a-canadian-collaborative
#9
Graeme M Rocker, Claudia Amar, Wendy L Laframboise, Jane Burns, Jennifer Y Verma
BACKGROUND: A year-long pan-Canadian quality improvement collaborative (QIC) led by the Canadian Foundation for Healthcare Improvement (CFHI) supported the spread of the successful Halifax, Nova Scotia-based INSPIRED COPD Outreach Program™ to 19 teams in the 10 Canadian provinces. We describe QIC results, addressing two main questions: 1) Can the results of the Nova Scotia INSPIRED model be replicated elsewhere in Canada? 2) How did the teams implement and evaluate their versions of the INSPIRED program? METHODS: Collaborative faculty selected measures that were evidence-based, relatively simple to collect, and relevant to local context...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28777823/two-new-risk-factors-for-heterotopic-ossification-development-after-severe-burns
#10
Laurent Thefenne, Gratiane de Brier, Thomas Leclerc, Claire Jourdan, Claire Nicolas, Stéphanie Truffaut, Eric Lapeyre, Francois Genet
OBJECTIVES: Life after severe burns is conditioned by the remaining sequelae. The pathophysiology and risk factors of Heterotopic Ossification (HO) after burns are still poorly understood. The aim of this study was to determine: 1) the incidence of HO after burns and 2) the risk factors associated with HO development, in a large retrospective study. METHODS: A case-control study of patients admitted to the burns intensive care unit of Percy Hospital, Paris, from the 1st January 2009 to the 31st December 2013 and then admitted to one of three centres specialised in the rehabilitation of patients with burns...
2017: PloS One
https://www.readbyqxmd.com/read/28777112/the-relationship-between-professional-quality-of-life-and-caring-ability-in-critical-care-nurses
#11
Marzieh Mohammadi, Hamid Peyrovi, Mahmood Mahmoodi
BACKGROUND: Critical care nursing has some features that may affect the ability of critical care nurses to provide care. Professionals as critical care nurses who deal with peoples' health and life often experience some levels of stress that affects their quality of life. OBJECTIVE: This study examined the relationship between professional quality of life and caring ability of critical care nurses. METHOD: In this descriptive correlational study, 253 critical care nurses working in the medical and surgical intensive care units of Tehran University of Medical Sciences were recruited by convenience sampling method...
September 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28771809/role-of-xist-mir-29a-lin28a-pathway-in-denatured-dermis-and-human-skin-fibroblasts-hsfs-after-thermal-injury
#12
Le Guo, Xu Huang, Pengfei Liang, Pihong Zhang, Minghua Zhang, Licheng Ren, Jizhang Zeng, Xv Cui, Xiaoyuan Huang
Denatured dermis is a part of the dermis in deep burn wound and has the ability to restore normal morphology and function. In our previous study, we revealed that miR-29a downregulation in denatured dermis may help burn wound healing in the later phase, and further enhance type I collagen synthesis. LIN28A, a highly-conserved RNA binding protein expressed during embryogenesis, plays roles in development, pluripotency, metabolism, as well as tissue repair in adults. In the present study, we investigated the functional roles of LIN28A in human skin fibroblasts (HSFs) and extracellular matrix (ECM), and the interaction between miR-29a and LIN28A...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28767264/human-urine-based-therapeutics-in-spain-from-the-early-20th-century-to-the-present-a-historical-literature-overview-and-a-present-day-case-study
#13
REVIEW
José Ramón Vallejo, Alfonso J Aparicio Mena, José Antonio González
Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. In this study we gather etnomedical knowledge about urotherapy and determine their associated symbolisms in Spain. A literature overview and a case study were carried out to compile urine-based remedies and as a direct analysis of symbolic systems. Urotherapy is widespread in Spanish folk medicine. Among the 204 collected remedies, those related to treatment of diseases or skin conditions predominate (63%)...
June 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28765489/embryonal-carcinoma-presenting-as-a-calcified-solitary-testicular-mass-on-ultrasound
#14
Daniel Gerber, Henry Collier Wright, Rachael D Sussman, Lambros Stamatakis
A 24-year-old man presented with a 2-week history of a painless right testicular mass; ultrasound demonstrated a dense, solitary calcified mass. The patient elected observation after further workup showed no evidence of metastasis.A repeat ultrasound 3 months later showed interval growth and the patient underwent right radical orchiectomy. Pathology was consistent with pure embryonal carcinoma of the testis. Calcified testicular masses are typically benign but do carry a differential of spermatic granuloma, large-cell calcifying Sertoli cell tumour, trauma, tuberculosis, filariasis, calcified Leydig cell tumour and burned-out testicular tumour...
July 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28763904/-discussion-on-the-related-problems-of-pediatric-burn-treatment
#15
Z Y Li, Z Lyu
The incidence of pediatric burn is high currently. Many clinical problems in the treatment of pediatric burn are composed of fluid replacement during shock stage, wound treatment, nutrition and metabolism etc, which urgently need to be sorted out and updated again to make corresponding clinical guidelines, criteria, or consensus for standardizing the clinical diagnosis and treatment, so as to improve the clinical treatment level of pediatric burn.
July 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28763733/finding-the-sweet-spot-developing-implementing-and-evaluating-a-burn-out-and-compassion-fatigue-intervention-for-third-year-medical-trainees
#16
Tara Tucker, Maryse Bouvette, Shauna Daly, Pamela Grassau
Medical trainees are at high risk for developing burnout. Introducing trainees to the risks of burnout and supporting identification and proactive responses to their 'warning' signs of compassion fatigue (CF) is critical in building resiliency. The authors developed and evaluated a burnout and CF program for third year trainees at a Canadian Medical School. Of 165 medical trainees who participated in the burnout and CF program, 59 (36%) provided evaluation and feedback of the program and its impact throughout their year...
July 22, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28763655/improved-source-apportionment-of-pahs-and-pb-by-integrating-pb-stable-isotopes-and-positive-matrix-factorization-application-pahs-a-historical-record-case-study-from-the-northern-south-china-sea
#17
Minggang Cai, Yan Lin, Meng Chen, Weifeng Yang, Huihong Du, Ye Xu, Shayen Cheng, Fangjian Xu, Jiajun Hong, Mian Chen, Hongwei Ke
To obtain the historical changes of pyrogenic sources, integrated source apportionment methods, which include PAH compositions, diagnostic ratios (DRs), Pb isotopic ratios, and positive matrix factorization (PMF) model, were developed and applied in sediments of the northern South China Sea. These methods provided a gradually clear picture of energy structural change. Spatially, Σ15PAH (11.3 to 95.5ng/g) and Pb (10.2 to 74.6μg/g) generally exhibited decreasing concentration gradient offshore; while the highest levels of PAHs and Pb were observed near the southern Taiwan Strait, which may be induced by accumulation of different fluvial input...
July 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28755597/a-13-year-study-of-dissolved-organic-carbon-in-rainwater-of-an-agro-industrial-region-of-s%C3%A3-o-paulo-state-brazil-heavily-impacted-by-biomass-burning
#18
Daniely Godoy-Silva, Raquel F P Nogueira, M Lucia A M Campos
This work presents the first comprehensive study of DOC in rainwater in a tropical agro-industrial region in central São Paulo State. The DOC concentrations ranged from 15 to 4992μmolCL(-1), with an overall volume weighted mean (VWM) of 288±17μmolCL(-1) (n=881). The number of fire spots accumulated within each year of this study was positively correlated to the VWM concentration of DOC in rainwater. During the whole study period, higher VWM DOC concentrations were found during the dry months, despite the phasing out of agricultural fires in sugar cane plantations...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28748166/assessment-of-immunomodulatory-activity-of-aqueous-extract-of-calamus-rotang
#19
Amit Gupta, Sushama Ravindra Chaphalkar
OBJECTIVE: There are a number of medicinal plant products which has been used to treat various immunological diseases. Out of these medicinal plants, Calamus rotang has shown several medicinal properties including anti-viral, anti-diabetic, anti-inflammatory effects. Normally, the roots of C. rotang are used in various ailments to cure piles, burning sensation, cough, leprosy and bleeding disorder and also it was used in the treatment of inflammation. In the present study, our group were investigated the immunomodulatory activity of aqueous extract of C...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28738899/a-rare-manifestation-of-burns-after-lightning-strike-in-rural-ghana-a-case-report
#20
Paschal Awingura Apanga, John Atigiba Azumah, Joseph Bayewala Yiranbon
BACKGROUND: Lightning is a natural phenomenon that mostly affects countries in the tropical and subtropical regions of the globe, including Ghana. Lightning strikes pose a global public health issue. Although strikes to humans are uncommon, it is associated with high morbidity and mortality. CASE PRESENTATION: We present a case of a 10-year-old Ghanaian girl who got second-degree burns after being struck by lightning. She was put on an intravenous broad-spectrum antibiotic (ceftriaxone), Ringer's lactate, and her burns were dressed with sterile gauze impregnated with Vaseline (petroleum jelly) and silver sulfadiazine ointment...
July 25, 2017: Journal of Medical Case Reports
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