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https://www.readbyqxmd.com/read/27897383/photoswitchable-and-watersoluble-fluorescence-nano-aggregates-based-on-diarylethene-dansyl-dyad-and-liposome
#1
Hongbo Cheng, Pin Ma, Yanan Wang, Guofei Hu, Shibi Fang, Yanyan Fang, Yuan Lin
In this work, a unique approach is developed to generate photoswitchable and watersoluble fluorescence nano-aggregates. Initially, a new light-controlled diarylethene-dansyl dyad DAEs 1 is formed by two dansyl fluorophores covalently linked to a symmetrical dithienylethene backbone, whose photophysical properties can be excellent reversibly switched by optical stimuli. Subsequently, the water-insolubility of molecular switch DAEs 1 is overcome by incorporating it into the bilayer of liposome DPPC (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) in water...
November 29, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27875847/duodenal-arteriovenous-malformation-endosonographic-diagnosis-and-coil-embolization
#2
Shibi Mathew, Prakash Zacharias, Lijesh Kumar, John Mathews, Prashanth Menon, Mathew Philip
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27704358/a-humanized-chimeric-antibody-hai178-targeted-to-the-%C3%AE-subunit-of-f1f0-atp-synthase
#3
Chen Chen, Hui Liang, Xinmei Liao, Jian Pan, Jianhe Chen, Shibi Zhao, Yan Xu, Yun Wu, Jian Ni
Inhibition of tumor vasculature is an effective strategy for cancer therapy. Angiostatin could suppress tumor growth and metastasis by binding and inhibiting F1F0 ATP synthase on the endothelial cell surface. We previously screened a monoclonal antibody (McAb, McAb178-5G10), which specifically bound to ATPase on the surface of cells and showed an angiostatin-like activity. Here, we further generated a panel of CHO-mAb subclone stable expressing a humanized chimeric antibody from hybridoma cell McAb178-5G10 by gene engineer...
October 4, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27688759/oligodendrocytes-contribute-to-motor-neuron-death-in-als-via-sod1-dependent-mechanism
#4
Laura Ferraiuolo, Kathrin Meyer, Thomas W Sherwood, Jonathan Vick, Shibi Likhite, Ashley Frakes, Carlos J Miranda, Lyndsey Braun, Paul R Heath, Ricardo Pineda, Christine E Beattie, Pamela J Shaw, Candice C Askwith, Dana McTigue, Brian K Kaspar
Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron (MN) hyperexcitability and death. Moreover, we efficiently derived human oligodendrocytes from a large number of controls and patients with sporadic and familial ALS, using two different reprogramming methods. All ALS oligodendrocyte lines induced MN death through conditioned medium (CM) and in coculture...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27494993/computational-strategies-to-explore-antimalarial-thiazine-alkaloid-lead-compounds-based-on-an-australian-marine-sponge-plakortis-lita
#5
Lilly Aswathy, Radhakrishnan S Jisha, Vijay H Masand, Jayant M Gajbhiye, Indira G Shibi
In this work, an attempt was made to propose new leads based on the natural scaffold Thiaplakortone-A active against malaria. The 2D QSAR studies suggested that three descriptors correlate with the anti-malarial activity with an R(2) value of 0.814. Robustness, reliability and predictive power of the model were tested by internal validation, external validation, Y-scrambling and Applicability domain analysis. HQSAR studies were carried out as an additional tool to find the sub-structural fingerprints. The CoMFA and CoMSIA models gave Q(2) values of 0...
August 5, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27455627/microstructure-and-nanomechanical-properties-of-single-trabecular-bone-in-different-regions-of-osteonecrosis-of-the-femoral-head
#6
Cheng Wang, Yu Wang, Haoye Meng, Wenlong Gou, Xueling Yuan, Xiaolong Xu, Aiyuan Wang, Quanyi Guo, Jiang Peng, Shibi Lu
This study aimed to compare the microstructure and nanomechanical properties of single trabecular bone in different regions of osteonecrosis of the femoral head. Osteonecrotic femoral heads were taken from 20 patients undergoing total hip arthroplasties between 2011 and 2014. Following incision, resin was embedded and polished, and divided into four regions according to the type of pathologic change; i.e., subchondral bone, and necrotic, sclerotic, and healthy regions. Indents from a single trabecular bone of each region were randomly selected to undergo nanoindentation...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27242788/host-intracellular-signaling-events-and-pro-inflammatory-cytokine-production-in-african-trypanosomiasis
#7
REVIEW
Shiby M Kuriakose, Rani Singh, Jude E Uzonna
Pathogens, such as bacteria, viruses, and parasites, possess specific molecules or proteins that are recognized by several host innate immune receptors, leading to the activation of several intracellular signaling molecules and pathways. The magnitude and quality of these events significantly affect the outcome of infection. African trypanosomes, including Trypanosoma congolense, are capable of manipulating the host immune response, including the activity of macrophages, which are the key immune cells that contribute to the immunopathogenesis of African trypanosomiasis...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27219912/clinical-characteristics-and-dose-volume-histogram-parameters-associated-with-the-development-of-pleural-effusions-in-non-small-cell-lung-cancer-patients-treated-with-chemoradiation-therapy
#8
Matthew P Deek, Sairaman Nagarajan, Sinae Kim, Inaya Ahmed, Shiby Paul, Eli D Scher, Matthew Listo, Andrew Chen, Joseph Aisner, Sabiha Hussain, Bruce G Haffty, Salma K Jabbour
BACKGROUND: To investigate descriptive characteristics and dose metric (DM) parameters associated with development of pleural effusions (PlEf) in non-small cell lung cancer (NSCLC) treated with definitive chemoradiation therapy (CRT). MATERIALS AND METHODS: We retrospectively assessed treatment records and follow-up imaging of 66 NSCLC patients to identify PlEf formation after CRT. PlEf association between mean heart dose (MHD), mean lung dose (MLD), heart V5-V60 (HV), and lung V5-V60 (LV) were evaluated using Cox Proportional Hazard Models...
August 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27095535/virtual-screening-techniques-to-probe-the-antimalarial-activity-of-some-traditionally-used-phytochemicals
#9
Indira G Shibi, Lilly Aswathy, Radhakrishnan S Jisha, Vijay H Masand, Jayant M Gajbhiye
Malaria parasites show resistance to most of the antimalarial drugs and hence developing antimalarials which can act on multitargets rather than a single target will be a promising strategy of drug design. Here we report a new approach by which virtual screening of 292 unique phytochemicals present in 72 traditionally important herbs is used for finding out inhibitors of plasmepsin-2 and falcipain-2 for antimalarial activity against P. falciparum. Initial screenings of the selected molecules by Random Forest algorithm model of Weka using the bioassay datasets AID 504850 and AID 2302 screened 120 out of the total 292 phytochemicals to be active against the targets...
2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27062141/molecular-mechanisms-in-the-initiation-phase-of-wallerian-degeneration
#10
REVIEW
Biao Chang, Qi Quan, Shibi Lu, Yu Wang, Jiang Peng
Axonal degeneration is an early hallmark of nerve injury and many neurodegenerative diseases. The discovery of the Wallerian degeneration slow mutant mouse, in which axonal degeneration is delayed, revealed that Wallerian degeneration is an active progress and thereby illuminated the mechanisms underlying axonal degeneration. Nicotinamide mononucleotide adenylyltransferase 2 and sterile alpha and armadillo motif-containing protein 1 play essential roles in the maintenance of axon integrity by regulating the level of nicotinamide adenine dinucleotide, which seems to be the key molecule involved in the maintenance of axonal health...
August 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/26928464/major-histocompatibility-complex-class-i-molecules-protect-motor-neurons-from-astrocyte-induced-toxicity-in-amyotrophic-lateral-sclerosis
#11
SungWon Song, Carlos J Miranda, Lyndsey Braun, Kathrin Meyer, Ashley E Frakes, Laura Ferraiuolo, Shibi Likhite, Adam K Bevan, Kevin D Foust, Michael J McConnell, Christopher M Walker, Brian K Kaspar
Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to motor neurons (MNs) and play a non-cell autonomous role in disease pathogenesis. The mechanisms underlying the susceptibility of MNs to cell death remain unclear. Here we report that astrocytes derived from either mice bearing mutations in genes associated with ALS or human subjects with ALS reduce the expression of major histocompatibility complex class I (MHCI) molecules on MNs; reduced MHCI expression makes these MNs susceptible to astrocyte-induced cell death...
April 2016: Nature Medicine
https://www.readbyqxmd.com/read/26875280/-fluorescence-distribution-in-bone-and-cartilage-tissue-by-sectioning-of-frozen-undecalcified-bone
#12
Zhen Sun, Heyong Yin, Xiang Sui, Xiaoming Yu, Jiang Peng, Yu Wang, Aiyuan Wang, Quanyi Guo, Liu Shuyun, Haoye Meng, Shibi Lu
OBJECTIVE: To introduce a technique of frozen sections for undecalcified bone and discuss its feasiblity by observing the fluorescence distribution of the bone and cartilage. METHODS: The male Sprague Dawley transgenic rats at the age of 8 weeks, which express green fluoreschent protein were selected to isolate the whole knee sectioned by teh undecalicified bone fronze section techynique. Under the fluorescence and light microscopy, the fluorescence and structure were observed within the organization of slice...
November 2015: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/26860743/the-attitudes-of-medical-students-toward-the-importance-of-understanding-classical-greek-and-latin-in-the-development-of-an-anatomical-and-medical-vocabulary
#13
Shiby Stephens, Bernard John Moxham
Students on entering medical school are faced with acquiring new, and voluminous, anatomical and medical terminologies. A reason why acquiring these terminologies may be problematic relates to the fact that many terms are derived from classical Greek and Latin; languages nowadays that are rarely taught at school. It might also be supposed that the often reported reduction in exposure to anatomy, and time spent in the dissection room, impairs the students' knowledge and understanding of anatomical relationships, and thus further complicates the acquisition of the terminologies...
September 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/26802442/induction-of-mesenchymal-stem-cell-chondrogenic-differentiation-and-functional-cartilage-microtissue-formation-for-in-vivo-cartilage-regeneration-by-cartilage-extracellular-matrix-derived-particles
#14
Heyong Yin, Yu Wang, Zhen Sun, Xun Sun, Yichi Xu, Pan Li, Haoye Meng, Xiaoming Yu, Bo Xiao, Tian Fan, Yiguo Wang, Wenjing Xu, Aiyuan Wang, Quanyi Guo, Jiang Peng, Shibi Lu
UNLABELLED: We propose a method of preparing a novel cell carrier derived from natural cartilage extracellular matrix (ECM), designated cartilage ECM-derived particles (CEDPs). Through a series of processes involving pulverization, sieving, and decellularization, fresh cartilage was made into CEDPs with a median diameter of 263 ± 48 μm. Under microgravity culture conditions in a rotary cell culture system (RCCS), bone marrow stromal cells (BMSCs) can proliferate rapidly on the surface of CEDPs with high viability...
March 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26790289/-study-on-origin-and-authentication-of-medicinal-materials-of-dalbergiae-lignum-in-crude-drug-s-market
#15
Wen-qi Liu, Yi-yun Lu, Si-yu Ma, Feng Wei, Shuang-cheng Ma
The study is aimed to distinguish morphological characteristics of Dalbergiae Lignum collected from crude drug's markets and establish a identification methods and the quality standard for Dalbergiae Lignum. The macroscopic and microscopic features of Dalbergiae Lignum from crude drug's market were observed, analyzed and compared according to Hongmu specification issued by the People's Republic of China in 2000, and by the characteristics recorded in domestic monograph of Mucai Shibie (wood identification)...
August 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26239771/understanding-complete-oxidation-of-methane-on-spinel-oxides-at-a-molecular-level
#16
Franklin Feng Tao, Jun-Jun Shan, Luan Nguyen, Ziyun Wang, Shiran Zhang, Li Zhang, Zili Wu, Weixin Huang, Shibi Zeng, P Hu
It is crucial to develop a catalyst made of earth-abundant elements highly active for a complete oxidation of methane at a relatively low temperature. NiCo2O4 consisting of earth-abundant elements which can completely oxidize methane in the temperature range of 350-550 °C. Being a cost-effective catalyst, NiCo2O4 exhibits activity higher than precious-metal-based catalysts. Here we report that the higher catalytic activity at the relatively low temperature results from the integration of nickel cations, cobalt cations and surface lattice oxygen atoms/oxygen vacancies at the atomic scale...
2015: Nature Communications
https://www.readbyqxmd.com/read/26199629/advances-and-prospects-in-tissue-engineered-meniscal-scaffolds-for-meniscus-regeneration
#17
REVIEW
Weimin Guo, Shuyun Liu, Yun Zhu, Changlong Yu, Shibi Lu, Mei Yuan, Yue Gao, Jingxiang Huang, Zhiguo Yuan, Jiang Peng, Aiyuan Wang, Yu Wang, Jifeng Chen, Li Zhang, Xiang Sui, Wenjing Xu, Quanyi Guo
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA...
2015: Stem Cells International
https://www.readbyqxmd.com/read/26006759/molecular-docking-and-qsar-analyses-for-understanding-the-antimalarial-activity-of-some-7-substituted-4-aminoquinoline-derivatives
#18
I G Shibi, L Aswathy, R S Jisha, V H Masand, A Divyachandran, J M Gajbhiye
The quinoline moiety is one of the widely studied scaffolds for generating derivatives with various pharmacophoric groups due to its potential antimalarial activities. In the present study, a series of 7-substituted-4-aminoquinoline derivatives were selected to understand their antimalarial properties computationally by molecular modeling techniques including 2D QSAR, comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and molecular docking. The 2D-QSAR model built with four descriptors selected by genetic algorithm technique and CoMFA model showed satisfactory statistical results (Q(2)=0...
September 18, 2015: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25875604/the-b-cell-adaptor-molecule-bam32-is-critically-important-for-optimal-antibody-response-and-resistance-to-trypanosoma-congolense-infection-in-mice
#19
Chukwunonso Onyilagha, Ping Jia, Nipun Jayachandran, Sen Hou, Ifeoma Okwor, Shiby Kuriakose, Aaron Marshall, Jude E Uzonna
BACKGROUND: Bam32, a 32 kDa adaptor molecule, plays important role in B cell receptor signalling, T cell receptor signalling and antibody affinity maturation in germinal centres. Since antibodies against trypanosome variant surface glycoproteins (VSG) are critically important for control of parasitemia, we hypothesized that Bam32 deficient (Bam32-/-) mice would be susceptible to T. congolense infection. METHODOLOGY/PRINCIPAL FINDINGS: We found that T. congolense-infected Bam32-/- mice successfully control the first wave of parasitemia but then fail to control subsequent waves and ultimately succumb to their infection unlike wild type (WT) C57BL6 mice which are relatively resistant...
April 2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25509782/-an-in-vitro-study-on-three-dimensional-cultivation-with-dynamic-compressive-stimulation-for-cartilage-tissue-engineering
#20
Wang Yongcheng, Haoye Meng, Yuan Xueling, Jiang Peng, Quanyi Guo, Shibi Lu, Aiyuan Wang
OBJECTIVE: To investigate the effect of three-dimensional cultivation with dynamic compressive stimulation on promotion of cartilage growth in vitro, by constructing tissue engineered cartilage with three-dimensional porous articular cartilage extracellular matrix (ECM) scaffolds laden with rabbit chondrocytes and performing mechanical stimulation by compressive stress in bioreactor. METHODS: Chondrocytes of healthy adult New Zealand rabbits were isolated, and passage 2 chondrocytes were seeded onto three-dimensional porous articular cartilage ECM scaffolds for 5 days pre-cultivation, and then were divided into 2 groups: Group A continued static culture as control; group B (dynamic culture condition) underwent dynamic compressive strain stimulation (compressive strain of 15%, frequence of 1 Hz) in a bioreactor...
September 2014: Chinese Journal of Reparative and Reconstructive Surgery
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