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https://www.readbyqxmd.com/read/29223650/dry-eye-following-cataract-surgery-the-effect-of-light-exposure-using-an-in-vitro-model
#1
Tugce Ipek, Mariana Petronela Hanga, Andreas Hartwig, James Wolffsohn, Clare O'Donnell
PURPOSE: Cataract surgery can lead to the temporary development or worsening of dry eye symptoms. Contributing factors may include corneal incisions, agents used before, during or after surgery, light from the operating microscope, disruption of ocular surface tissues and inflammatory processes. The purpose of this study was to observe the effect of light exposure on conjunctival fibroblasts in order to determine whether light has an effect on wound healing closure, assuming that operating microscopes might have an effect on the ocular surface...
December 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29223649/novel-liposome-based-and-in-situ-gelling-artificial-tear-formulation-for-dry-eye-disease-treatment
#2
Duygu Acar, Irene Teresa Molina-Martínez, Miguel Gómez-Ballesteros, Manuel Guzmán-Navarro, José Manuel Benítez-Del-Castillo, Rocío Herrero-Vanrell
PURPOSE: Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation, containing both lipid and aqueous components, in order to resemble natural tears and replenish the tear film. METHODS: Liposomes, containing phosphatidylcholine, cholesterol, vitamins A and E, were prepared by the thin-film hydration method...
December 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29222450/elevation-of-autophagy-markers-in-sj%C3%A3-gren-syndrome-dry-eye
#3
Yong-Soo Byun, Hyun Jung Lee, Soojung Shin, So-Hyang Chung
Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhibited lower Schirmer values, lower tear breakup time, and higher ocular staining scores. In tears, ATG5 and LC3B-II/I levels were significantly higher in SS dry eye. ATG5 and LC3B-II mRNA in the conjunctiva were also elevated in SS dry eye compared with non-SS dry eye...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220066/periorbital-changes-associated-with-topical-prostaglandins-analogues-in-a-hispanic-population
#4
Ferdinand Rodríguez-Agramonte, Juan Carlos Jiménez, José Raúl Montes
OBJECTIVE: To describe the prevalent side effects of prostaglandin analogues (PA) in a Hispanic population and their effect on quality of life (QOL). PATIENTS AND METHODS: This is a cross-sectional study conducted in a tertiary medical facility in which patients were evaluated in a single visit. Total of 14 participants in the study, 10 women and 4 men. Ages ranged from 26-78 years old. Subjects underwent a single full Oculoplastic evaluation by two physicians; one was blinded on patient medical history and assessed for PA side effects...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#5
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29214311/fingolimod-suppresses-a-cascade-of-core-vicious-cycle-in-dry-eye-nod-mouse-model-involvement-of-sphingosine-1-phosphate-receptors-in-infiltrating-leukocytes
#6
Weibao Xiao, Shuhao Fu, Kang Xu, Ronghua Feng, Fei Sun, Wen Ye
Purpose: The purpose of this study was to evaluate the inhibitory mechanism of fingolimod and the involvement of sphingosine-1-phosphate receptors (S1PRs) and cytokines-matrix metalloproteinases (MMPs)/MAP kinases (MAPKs) signaling in a dry eye disease (DED) mouse model. Methods: Sixty-four male NOD mice (DED model) and 16 age-matched BALB/c mice were used. In a preliminary experiment, 16 NOD mice were randomly divided into a positive control group and fingolimod-treated groups, with 8 BALB/c mice serving as wild-type control...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29214310/tear-levels-of-insulin-like-growth-factor-binding-protein-3-correlate-with-subbasal-nerve-plexus-changes-in-patients-with-type-2-diabetes-mellitus
#7
Whitney L Stuard, Rossella Titone, Danielle M Robertson
Purpose: This study investigated the expression of insulin-like growth factor binding protein-3 (IGFBP-3) in basal tears of patients with type 2 diabetes mellitus compared to nondiabetic controls; and correlated tear levels of IGFBP-3 with morphologic changes in the subbasal nerve plexus and density of basal corneal epithelial cells. Methods: This was a single visit, cross-sectional study. Diabetic and control subjects were matched for age, sex, smoking status, and body mass index...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29212034/gadd34-function-in-protein-trafficking-promotes-adaptation-to-hyperosmotic-stress-in-human-corneal-cells
#8
Dawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan P Pattabiraman, Raul Jobava, Xing-Huang Gao, Xiao-Jing Di, Martin D Snider, Ting-Wei Mu, Shijie Liu, Brian Storrie, Eric Pearlman, Anna Blumental-Perry, Maria Hatzoglou
GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated stress response (ISR) pathway. Adaptation to hyperosmotic stress is important for the health of corneal epithelial cells exposed to changes in extracellular osmolarity, with maladaptation leading to dry eye syndrome. This adaptation includes induction of SNAT2, an endoplasmic reticulum (ER)-Golgi-processed protein, which helps to reverse the stress-induced loss of cell volume and promote homeostasis through amino acid uptake...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29211358/chest-hrct-findings-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#9
Agata Sebastian, Maria Misterska-Skóra, Jurand Silicki, Maciej Sebastian, Piotr Wiland
BACKGROUND: Pulmonary manifestations (PMs) in primary Sjögren's syndrome (pSS) are among the most frequent extraglandular complications, with reported prevalence varying widely (9-75%), depending on the methods of detection. OBJECTIVES: The aim of this study was to assess the incidence of PMs in pSS and to determine the factors predisposing to the occurrence of this complication. MATERIAL AND METHODS: The study group consisted of 68 patients with pSS...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29210535/assessment-care-and-management-of-patients-with-red-eye
#10
Susan Watkinson, Ramesh Seewoodhary
Red eye is a common ocular presentation in primary care, and there are several challenges that healthcare practitioners may encounter when caring for such patients. The main ocular conditions that can give rise to red eye are: primary acute angle closure glaucoma, acute iritis, dry eye, blepharitis and conjunctivitis. Red eye can be classified as sight-threatening or non-sight-threatening. Many patients presenting with painless red eye and normal vision usually recover well. However, when red eye is associated with pain, photophobia, watering and blurred vision, it is potentially sight-threatening and must be addressed urgently...
December 6, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29209436/the-potential-relationship-between-flammer-and-sj%C3%A3-gren-syndromes-the-chime-of-dysfunction
#11
REVIEW
Babak Baban, Olga Golubnitschaja
Flammer syndrome (FS) is a term to blanket a cluster of vascular and nonvascular signs and symptoms linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. On one hand, disruption of blood barrier and homeostasis of the body are the main targets of vascular irregularity. Inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29207448/are-serum-vitamin-d-levels-associated-with-dry-eye-disease-results-from-the-study-group-for-environmental-eye-disease
#12
Da-Hye Jeon, Hyungseon Yeom, Jaewon Yang, Jong Suk Song, Hyung Keun Lee, Hyeon Chang Kim
Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015)...
November 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/29205873/evaluation-of-dry-eye-using-anterior-segment-optical-coherence-tomography-in-patients-with-end-stage-renal-disease-undergoing-hemodialysis
#13
Öznur Kal, Mahmut Oğuz Ulusoy, Ali Kal, Gülşah Tanriaşki, Şefik Cezairlioğlu
The aim of the present study was to evaluate dry eye parameters with conventional tests and tear meniscus with Anterior Segment Optical Coherence Tomography (AS-OCT) in patients with end-stage renal disease (ESRD). Thirty-eight ESRD patients undergoing hemodialysis, and 40 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered. Before conventional dry eye tests, tear meniscus were evaluated using AS-OCT. After a complete ocular examination, Schirmer and break-up time (BUT) tests were performed and probable corneal staining was investigated...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29204644/topical-application-of-mizoribine-suppresses-cd4-t-cell-mediated-pathogenesis-in-murine-dry-eye
#14
Xiaobo Zhang, Xiang Lin, Zhaolin Liu, Yang Wu, Yiran Yang, Weijie Ouyang, Wei Li, Zuguo Liu
Purpose: We investigate the effect of topical application of mizoribine (MZR) eye drops on CD4+ T-cell-mediated immunity and epithelial damage in ocular surface of dry eye disease (DED). Methods: Topical application of MZR or vehicle eye drops was performed in mice subjected to desiccating stress (DS). The phenol red cotton test was used to measure tear production, and Oregon-green-dextran (OGD) staining was performed to assess corneal epithelial barrier function...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29200970/systematic-review-of-randomized-controlled-trials-in-the-treatment-of-dry-eye-disease-in-sjogren-syndrome
#15
REVIEW
Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong, Louis Tong
Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Fluoromethalone eye drops over 8 weeks were more effective than topical cyclosporine in the treatment of dry eye symptoms and signs; similarly, indomethacin eye drops over 1 month were more efficacious than diclofenac eye drops...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/29195358/novel-single-cell-mega-size-chambers-for-electrochemical-etching-of-panorama-position-sensitive-polycarbonate-ion-image-detectors
#16
Mehdi Sohrabi
A novel development is made here by inventing panorama single-cell mega-size electrochemical etching (MS-ECE) chamber systems for processing panorama position-sensitive mega-size polycarbonate ion image detectors (MS-PCIDs) of potential for many neutron and ion detection applications in particular hydrogen ions or proton tracks and images detected for the first time in polycarbonates in this study. The MS-PCID is simply a large polycarbonate sheet of a desired size. The single-cell MS-ECE invented consists of two large equally sized transparent Plexiglas sheets as chamber walls holding a MS-PCID and the ECE chamber components tightly together...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29190232/macular-atrophy-findings-by-optical-coherence-tomography-angiography-compared-with-fundus-autofluorescence-in-treated-exudative-age-related-macular-degeneration
#17
Yukari Takasago, Chieko Shiragami, Mamoru Kobayashi, Rie Osaka, Aoi Ono, Ayana Yamashita, Akitaka Tsujikawa, Kazuyuki Hirooka
PURPOSE: To compare the areas of choriocapillaris (CC) nonperfusion and macular atrophy (MA) in treated exudative age-related macular degeneration. METHODS: This was a prospective, observational, cross-sectional study. Forty-four eyes exhibiting MA (42 patients with age-related macular degeneration), with a dry macula, underwent fundus autofluorescence and optical coherence tomography angiography. The area of MA detected by fundus autofluorescence and CC nonperfusion detected by optical coherence tomography angiography was measured using image analysis software...
November 28, 2017: Retina
https://www.readbyqxmd.com/read/29189737/novel-artificial-tears-containing-cross-linked-hyaluronic-acid-an-in-vitro-re-epithelialization-study
#18
Arianna Fallacara, Silvia Vertuani, Giacomo Panozzo, Alessandra Pecorelli, Giuseppe Valacchi, Stefano Manfredini
Dry eye syndrome is a common disease which can damage the corneal epithelium. It is treated with eye drops to stimulate tear production and hydrate the corneal surface. The most prescribed artificial tear remedies contain hyaluronic acid (HA), which enhances epithelial wound healing, improving tissue health. To the best of our knowledge, only a few recent studies have investigated cross-linked HA (HA-CL) in eye drops for human applications. This work consists in an in vitro evaluation of the re-epithelialization ability of two different preparations containing a recently synthetized HA cross-linked with urea: 0...
November 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29185841/inhibitory-effect-of-amitriptyline-on-the-impulse-activity-of-cold-thermoreceptor-terminals-of-intact-and-tear-deficient-guinea-pig-corneas
#19
Takayoshi Masuoka, Juana Gallar, Carlos Belmonte
PURPOSE: Chronic dryness of the ocular surface evokes sensitization of corneal cold-sensitive neurons through an increase of sodium currents and a decrease of potassium currents, leading to the unpleasant dryness and pain sensations typical of dry eye disease. Here, we explored the effects of amitriptyline, a voltage-gated Na+ channel blocker used for the treatment of depression and chronic pain, on nerve terminal impulse (NTI) activity of cold-sensitive nerve terminals recorded in intact and tear-deficient guinea pig corneas...
November 29, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29184385/aflibercept-treatment-for-neovascular-amd-beyond-the-first-year-consensus-recommendations-by-a-uk-expert-roundtable-panel-2017-update
#20
EDITORIAL
Praveen J Patel, Helen Devonport, Sobha Sivaprasad, Adam H Ross, Gavin Walters, Richard P Gale, Andrew J Lotery, Sajjad Mahmood, James S Talks, Jackie Napier
National recommendations on continued administration of aflibercept solution for injection after the first year of treatment for neovascular age-related macular degeneration (nAMD) have been developed by an expert panel of UK retina specialists, based on clinician experience and treatment outcomes seen in year 2. The 2017 update reiterates that the treatment goal is to maintain or improve the macular structural and functional gains achieved in year 1 while attempting to reduce or minimize the treatment burden, recognizing the need for ongoing treatment...
2017: Clinical Ophthalmology
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