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Dysplasia bronchopulmonary

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https://www.readbyqxmd.com/read/29453434/post-ligation-cardiac-syndrome-is-associated-with-increased-morbidity-in-preterm-infants
#1
Timothy J B Ulrich, Taylor P Hansen, Kimberly J Reid, Michael A Bingler, Steven L Olsen
OBJECTIVE: The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP). STUDY DESIGN: Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29447482/role-of-vitamin-a-supplementation-in-prevention-of-bronchopulmonary-dysplasia-in-extremely-low-birth-weight-neonates-a-systematic-review-of-randomized-trials
#2
Bhawan Deep Garg, Anju Bansal, Nandkishor S Kabra
BACKGROUND: Bronchopulmonary dysplasia (BPD) is one of the most common consequence of extreme prematurity (< 28 weeks of gestation). BPD affects approximately 55% of extremely low birth weight (ELBW) neonates. AIMS: The aim of this systematic review is to evaluate the role of vitamin A supplementation in prevention of BPD in ELBW neonates. METHOD: The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE and ongoing clinical trials...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29437799/high-versus-standard-dose-caffeine-for-apnoea-a-systematic-review
#3
Roos Vliegenthart, Martijn Miedema, Gerard J Hutten, Anton H van Kaam, Wes Onland
BACKGROUND: Placebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). OBJECTIVE: To identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages. METHODS: A systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies...
February 7, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29433145/effect-of-cord-blood-magnesium-level-at-birth-on-non-neurologic-neonatal-outcomes
#4
James M Edwards, Laura E Edwards, Geeta K Swamy, Chad A Grotegut
OBJECTIVE: We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. STUDY DESIGN: We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29432836/quercetin-attenuates-the-hyperoxic-lung-injury-in-neonatal-mice-implications-for-bronchopulmonary-dysplasia-bpd
#5
Paramahamsa Maturu, Yanhong Wei-Liang, Vasilis P Androutsopoulos, Weiwu Jiang, Lihua Wang, Aristides M Tsatsakis, Xanthi I Couroucli
Quercetin (QU) is one of the most common flavonoids that are present in a wide variety of fruits, vegetables, and beverages. This compound possesses potent anti-inflammatory and anti-oxidant properties. Supplemental oxygen is routinely administered to premature infants with pulmonary insufficiency. However, hyperoxia is one of the major risk factors for the development of bronchopulmonary dysplasia (BPD), which is also termed chronic lung disease in premature infants. Currently, no preventive approaches have been reported against BPD...
February 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29431872/interventions-to-prevent-hypothermia-at-birth-in-preterm-and-or-low-birth-weight-infants
#6
REVIEW
Emma M McCall, Fiona Alderdice, Henry L Halliday, Sunita Vohra, Linda Johnston
BACKGROUND: Newborn admission temperature is a strong predictor of outcomes across all gestations. Hypothermia immediately after birth remains a worldwide issue and, if prolonged, is associated with harm. Keeping preterm infants warm is difficult even when recommended routine thermal care guidelines are followed in the delivery room. OBJECTIVES: To assess the efficacy and safety of interventions designed for prevention of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room, compared with routine thermal care or any other single/combination of intervention(s) also designed for prevention of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29429458/-burkholderia-cepacia-infection-in-children-a-clinical-analysis-of-16-cases
#7
Fang Peng, Li-Li Zhong, Xiao-Juan Lin, Min Chen, Miao Zhou
OBJECTIVE: To investigate the distribution characteristics and clinical features of Burkholderia cepacia infection in children. METHODS: A retrospective analysis was performed for the clinical data of 16 children with Burkholderia cepacia infection who were hospitalized between June 2012 and September 2017. RESULTS: All 16 children with Burkholderia cepacia infection were sporadic cases. A total of 16 strains of Burkholderia cepacia were isolated, among which 8 were detected by sputum culture, 5 were detected by blood culture, 2 were detected by tracheal intubation tip culture, and 1 was detected by lung biopsy culture...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29428947/a-combination-of-the-aerosolized-ppar-%C3%AE-agonist-pioglitazone-and-a-synthetic-surfactant-protein-b-peptide-mimic-prevents-hyperoxia-induced-neonatal-lung-injury-in-rats
#8
Reiko Sakurai, Cindy Lee, Humphrey Shen, Alan J Waring, Frans J Walther, Virender K Rehan
BACKGROUND: Despite improvements in perinatal care, bronchopulmonary dysplasia (BPD) in extremely premature infants has not decreased. Postnatal surfactant therapy provides symptomatic relief from respiratory distress syndrome, but does not translate into a reduction in BPD. Therefore, the search for effective interventions to prevent BPD continues. OBJECTIVES: Since PPAR-γ agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-γ agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone...
February 9, 2018: Neonatology
https://www.readbyqxmd.com/read/29428705/risk-factors-for-failure-in-the-newborn-hearing-screen-test-in-very-preterm-twins
#9
So Young Kim, Byung Yoon Choi, Eun Young Jung, Hyunsoo Park, Ha-Na Yoo, Kyo Hoon Park
BACKGROUND: We aimed to identify prenatal and postnatal risk factors associated with abnormal newborn hearing screen (NHS) results and subsequently confirmed sensorineural hearing loss (SNHL) in preterm twin neonates. METHODS: Electronic medical records of 159 twin neonates who were born alive after ≤32 weeks were retrospectively reviewed for hearing loss in both ears. Histopathologic examination of the placenta was performed and clinical data, including method of conception and factors specific to twins, were retrieved from a computerized perinatal database...
January 31, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29423017/aerosolized-deferoxamine-administration-in-mouse-model-of-bronchopulmonary-dysplasia-improve-pulmonary-development
#10
Yanru Chen, Sha Gao, Yufei Yan, Jihong Qian, Hao Chen
Bronchopulmonary dysplasia (BPD) is the most common complication in preterm newborns. It occurs due to early exposure to high-oxygen and ventilation therapy. The mechanisms of disrupted alveolarization and vascular development associated with BPD were unclear. Deferoxamine (DFO) has been reported to reduce mortality and lung injury in mice after chlorine exposure. The effect of DFO in the treatment of BPD has not been explored. This study aimed to investigate the effect of aerosolized DFO administration in a mouse model of BPD...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29420848/why-do-children-with-severe-bronchopulmonary-dysplasia-not-attend-neonatal-follow-up-care-parental-views-of-barriers
#11
Jennifer M Brady, Nicole Pouppirt, Judy Bernbaum, Jo Ann D'Agostino, Marsha Gerdes, Casey Hoffman, Noah Cook, Hallam Hurt, Haresh Kirpalani, Sara B DeMauro
AIM: To assess in children with severe bronchopulmonary dysplasia at a corrected age of 18-36 months: 1)Neonatal follow-up clinic attendance rates; 2)Parent-identified reasons for difficulty attending neonatal follow-up. METHODS: Mixed methods study utilizing semi-structured phone interviews with parents of infants eligible for follow-up with severe bronchopulmonary dysplasia (defined as gestational age <32 weeks and requiring ≥30% FiO2 and/or > two liters nasal cannula at 36 weeks postmenstrual age) at 18-36 months corrected age...
February 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29405832/beyond-sepsis-staphylococcus-epidermidis-is-an-underestimated-but-significant-contributor-to-neonatal-morbidity
#12
Ying Dong, Christian P Speer, Kirsten Glaser
Staphylococcus epidermidis accounts for the majority of cases of neonatal sepsis. Moreover, it has been demonstrated to be associated with neonatal morbidities, such as bronchopulmonary dysplasia (BPD), white matter injury (WMI), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP), which affect short-term and long-term neonatal outcome. Imbalanced inflammation has been considered to be a major underlying mechanism of each entity. Conventionally regarded as a harmless commensal on human skin, S...
February 6, 2018: Virulence
https://www.readbyqxmd.com/read/29398054/severe-neurodevelopmental-impairment-in-neonates-born-preterm-impact-of-varying-definitions-in-a-canadian-cohort
#13
Matthew D Haslam, Sarka Lisonkova, Dianne Creighton, Paige Church, Junmin Yang, Prakesh S Shah, K S Joseph, Anne Synnes
OBJECTIVE: To assess the impact of variations in the definition of severe neurodevelopmental impairment (NDI) on the incidence of severe NDI and the association with risk factors using the Canadian Neonatal Follow-Up Network cohort. STUDY DESIGN: Literature review of severe NDI definitions and application of these definitions were performed in this database cohort study. Infants born at 23-28 completed weeks of gestation between 2009 and 2011 (n = 2187) admitted to a Canadian Neonatal Network neonatal intensive care unit and assessed at 21 months' corrected age were included...
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29395887/palivizumab-administration-in-preterm-infants-in-france-epipage-2-cohort-study
#14
H Torchin, J Rousseau, L Marchand-Martin, P Truffert, P-H Jarreau, P-Y Ancel
BACKGROUND: Several countries, including France, have restricted the indications for monoclonal antibodies directed against respiratory syncytial virus (RSV) compared to the marketing authorization (MA). No new data concerning use of palivizumab on a national scale have been published since the 2007 update of the national guidelines. OBJECTIVES: To describe palivizumab administration for RSV prophylaxis during the first RSV season in infants born prematurely in France in 2011...
January 27, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29393348/decreased-zonab-expression-promotes-excessive-transdifferentiation-of-alveolar-epithelial-cells-in-hyperoxia-induced-bronchopulmonary-dysplasia
#15
Ana Hou, Jianhua Fu, Yongyan Shi, Lin Qiao, Jun Li, Yujiao Xing, Xindong Xue
Previous studies by our group have confirmed excessive transdifferentiation of alveolar epithelial cells (AECs) in a hyperoxia‑induced bronchopulmonary dysplasia (BPD) model, but the underlying mechanism have remained elusive. The transcription factor zonula occludens 1‑associated nucleic acid binding protein (ZONAB) has the biological functions of inhibition of epithelial cell differentiation and promotion of epithelial cell proliferation. The aim of the present study was to explore the regulatory effect of ZONAB on the transdifferentiation and proliferation of AECs in a model of hyperoxia‑induced lung injury...
January 23, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29393249/upregulation-of-vascular-endothelial-growth-factor-in-amniotic-fluid-stem-cells-enhances-their-potential-to-attenuate-lung-injury-in-a-preterm-rabbit-model-of-bronchopulmonary-dysplasia
#16
Julio Jiménez, Flore Lesage, Jute Richter, Taro Nagatomo, Thomas Salaets, Silvia Zia, Marina Gabriela Mori Da Cunha, Jeroen Vanoirbeek, Jan A Deprest, Jaan Toelen
BACKGROUND: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects extremely preterm infants and remains - despite improvements in neonatal intensive care - a major cause of neonatal mortality and morbidity. Cell-therapeutic strategies employing mesenchymal stem cells (MSC) have been shown to modulate lung development in BPD models. OBJECTIVE: Herein, we evaluate the potential of human amniotic fluid (hAF)-SC and hAF-SC with upregulated expression of vascular endothelial growth factor (VEGF) as cell-therapeutic agents for BPD...
February 1, 2018: Neonatology
https://www.readbyqxmd.com/read/29392321/retinopathy-of-prematurity-among-very-low-birth-weight-infants-in-china-incidence-and-perinatal-risk-factors
#17
Tian Wu, Li Zhang, Yu Tong, Yi Qu, Bin Xia, Dezhi Mu
Purpose: Retinopathy of prematurity (ROP) is the leading cause of blindness in children worldwide. This study aimed to determine the incidence and perinatal risk factors for ROP in very low-birth-weight (VLBW) Chinese infants. Methods: A retrospective study of the medical records of 504 VLBW infants screened for ROP from 2012 to 2015 was performed in West China Second University Hospital. VLBW infants were examined according to the Royal College of Ophthalmologists ROP guideline and retinopathy was graded following the International Classification of ROP...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29381192/brainstem-auditory-abnormality-in-extremely-premature-babies-and-the-impact-of-neonatal-bronchopulmonary-dysplasia
#18
Cui Wang, Ze Dong Jiang
INTRODUCTION: Extremely premature babies, particularly those who have neonatal bronchopulmonary dysplasia (BPD), are at risk of brain damage and neurodevelopmental impairment. This study aimed to examine functional status of the brainstem auditory pathway in extremely premature babies and assess the impact of BPD on the function. MATERIAL AND METHODS: Brainstem auditory evoked response was studied at term in babies born at 27 or less weeks of gestation with or without neonatal BPD...
January 30, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29374791/recent-advances-in-bronchopulmonary-dysplasia-pathophysiology-prevention-and-treatment
#19
REVIEW
Jung S Hwang, Virender K Rehan
Bronchopulmonary dysplasia (BPD) is potentially one of the most devastating conditions in premature infants with longstanding consequences involving multiple organ systems including adverse effects on pulmonary function and neurodevelopmental outcome. Here we review recent studies in the field to summarize the progress made in understanding in the pathophysiology, prognosis, prevention, and treatment of BPD in the last decade. The work reviewed includes the progress in understanding its pathobiology, genomic studies, ventilatory strategies, outcomes, and therapeutic interventions...
January 27, 2018: Lung
https://www.readbyqxmd.com/read/29370028/thrombocytopenia-as-a-risk-factor-for-retinopathy-of-prematurity
#20
Selim Sancak, Handan H Toptan, Tulin Gokmen Yildirim, Guner Karatekin, Fahri Ovali
PURPOSE: To study the association between thrombocytopenia and retinopathy of prematurity (ROP). METHODS: The case-control study was conducted on preterm newborns with ROP between January 2011 and January 2014, retrospectively. The patients were assigned into two groups: Cases required intervention and controls developed no or Stage I ROP. RESULTS: Eighty-one premature infants with Type I ROP were enrolled to the study with a mean gestational age of 27...
January 23, 2018: Retina
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