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Dysplasia bronchopulmonary

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https://www.readbyqxmd.com/read/29041034/inhaled-versus-systemic-corticosteroids-for-preventing-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-neonates
#1
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains an important cause of mortality and morbidity in preterm infants and inflammation plays a significant role in its pathogenesis. The use of inhaled corticosteroids may modulate the inflammatory process without concomitant high systemic steroid concentrations and less risk of adverse effects. This is an update of a review published in 2012 (Shah 2012). We recently updated the related review on "Inhaled versus systemic corticosteroids for treating bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates"...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29035757/pulmonary-hypertension-associated-with-bronchopulmonary-dysplasia-in-preterm-infants
#2
REVIEW
Christine B Bui, Merrin A Pang, Arvind Sehgal, Christiane Theda, Jason C Lao, Philip J Berger, Marcel F Nold, Claudia A Nold-Petry
Bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension (BPD-PH) are chronic inflammatory cardiopulmonary diseases with devastating short- and long-term consequences for infants born prematurely. The immature lungs of preterm infants are ill-prepared to achieve sufficient gas exchange, thus usually necessitating immediate commencement of respiratory support and oxygen supplementation. These therapies are life-saving, but they exacerbate the tissue damage that is inevitably inflicted on a preterm lung forced to perform gas exchange...
October 2, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#3
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29035091/inverse-relationship-between-soluble-rage-and-risk-for-bronchopulmonary-dysplasia
#4
John T Benjamin, Riet van der Meer, James C Slaughter, Steven Steele, Erin J Plosa, Jennifer M Sucre, Paul E Moore, Judy L Aschner, Timothy S Blackwell, Lisa R Young
No abstract text is available yet for this article.
October 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29033349/a-polymorphism-in-the-glucocorticoid-receptor-gene-is-associated-with-refractory-hypotension-in-premature-infants
#5
Kei Ogasawara, Maki Sato, Koichi Hashimoto, Takashi Imamura, Hayato Go, Mitsuaki Hosoya
BACKGROUND: Glucocorticoids play an important role in endocrine control. The association of glucocorticoid receptor (GR) gene polymorphisms with altered sensitivity to glucocorticoid therapy has been reported in adults. However, there are few such reports in infants. The present study analyzed the prevalence of four GR polymorphisms in preterm infants born before 30 weeks of gestation and determined the associations between these polymorphisms and clinical outcomes in the infants. METHODS: Totally, 41 preterm infants born at two hospitals in Fukushima were retrospectively screened for the presence of four GR gene polymorphisms, using a TaqMan single-nucleotide polymorphism genotyping assay...
September 27, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29031795/pulmonary-sequelae-and-functional-limitations-in-children-and-adults-with-bronchopulmonary-dysplasia
#6
REVIEW
Daniel T Malleske, Olena Chorna, Nathalie L Maitre
Preterm infants with bronchopulmonary dysplasia (BPD) often suffer from life-long pulmonary impairments in pulmonary physical function. This review summarizes our current understanding of the chronic pulmonary impairments and physical functional limitations associated with BPD from preterm birth to adulthood. It also identifies opportunities for intervention in children and adults living with chronic lung disease (CLD) after preterm birth.
August 24, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29025303/serum-surfactant-protein-d-as-a-marker-for-bronchopulmonary-dysplasia
#7
Suja Vinod, Andrew Gow, Barry Weinberger, Debra Potak, Mark Hiatt, Shaku Chandra, Thomas Hegyi
BACKGROUND: Lung epithelial cells express surfactant protein D (SP-D), a calcium-dependent lectin that plays an important role in antibody-independent pulmonary host defense. Previous studies have shown that it is found in the peripheral circulation in patients with pulmonary disease, likely because of translocation into the blood when lung epithelial barriers are disrupted by inflammation or acute injury. In adults, serum SP-D levels are biomarkers for the progression and severity of chronic lung disease...
October 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29021519/bone-marrow-mononuclear-cells-transplantation-in-treatment-of-established-bronchopulmonary-dysplasia-a-case-report
#8
Nguyen Thanh Liem, Tran Lien Anh, Trieu T Hong Thai, Bui Viet Anh
BACKGROUND Bronchopulmonary dysplasia (BDP) is an incurable disease. This study reports the successful treatment of a 30-week-old neonate with established bronchopulmonary dysplasia by bone marrow mononuclear cells (BM MNCs) transplantation. CASE REPORT The preterm infant with BPD requiring continuous oxygen administration for 4 months post-delivery underwent BM MNCs. Bone marrow was obtained from the patient's iliac crests and mononuclear cells were isolated by density gradient centrifugation method. BM MNCs were delivered via endotracheal and intravenous routes...
October 12, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29019629/health-disparities-and-child-development-after-prematurity
#9
Frances A Carter, Michael E Msall
There is increased recognition that preterm neonates require sequential surveillance to capture the spectrum of coordination, communication, learning, and behavior regulation disorders that may occur in the first 5 years of life and beyond. In particular, the framework of follow-up needs to go beyond the detection of cerebral palsy, blindness, and deafness in the first 2 years of life for only those at highest preterm risk (ie, <28 weeks gestation, with combinations of severe cranial sonographic abnormalities, bronchopulmonary dysplasia, and retinopathy of prematurity)...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28975628/predictors-of-prolonged-length-of-hospital-stay-or-readmissions-for-acute-viral-lower-respiratory-tract-infections-among-infants-with-a-history-of-bronchopulmonary-dysplasia
#10
Carlos E Rodríguez-Martínez, Ranniery Acuña-Cordero, Monica P Sossa-Briceño
BACKGROUND: Length of hospital stay and readmissions are outcome measures that have been largely overlooked in many studies that have evaluated the clinical evolution of pediatric patients with bronchopulmonary dysplasia (BPD). The aim of the present study was to identify predictors of prolonged hospitalizations or readmissions for acute lower respiratory infections (ALRIs) in infants with BPD. METHODS: In a prospective cohort study, we determined independent predictors of prolonged hospitalizations or readmissions for ALRIs during the first two years of life in a population of infants with BPD living in Bogota, Colombia...
October 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28973344/effect-of-inhaled-nitric-oxide-on-survival-without-bronchopulmonary-dysplasia-in-preterm-infants-a-randomized-clinical-trial
#11
Shabih U Hasan, Jim Potenziano, Girija G Konduri, Jose A Perez, Krisa P Van Meurs, M Whit Walker, Bradley A Yoder
Importance: Bronchopulmonary dysplasia (BPD) occurs in approximately 40% of infants born at younger than 30 weeks' gestation and is associated with adverse pulmonary and neurodevelopmental outcomes. Objective: To test whether administration of inhaled nitric oxide to preterm infants requiring positive pressure respiratory support on postnatal days 5 to 14 improves the rate of survival without BPD. Design, Setting, and Participants: This intent-to-treat study was a randomized clinical trial performed at 33 US and Canadian neonatal intensive care units...
September 25, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28972960/strategies-to-enhance-paracrine-potency-of-transplanted-mesenchymal-stem-cells-in-intractable-neonatal-disorders
#12
REVIEW
Won Soon Park, So Yoon Ahn, Se In Sung, Jee-Yin Ahn, Yun Sil Chang
Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment and direct differentiation of transplanted MSCs, and the 'hit and run' therapeutic effects of these MSCs suggest that their pleiotropic protection might be attributable to paracrine activity via the secretion of various biologic factors rather than to regenerative activity...
October 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28971976/recent-advances-in-our-understanding-of-the-mechanisms-of-late-lung-development-and-bronchopulmonary-dysplasia
#13
David Emanuel Surate Solaligue, José Alberto Rodríguez-Castillo, Katrin Ahlbrecht, Rory E Morty
The objective of lung development is to generate an organ of gas exchange that provides both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly generates a steep gas-diffusion concentration gradient. As such, the lung is perfectly structured to undertake the function of gas exchange: a large number of small alveoli provide extensive surface area within the limited volume of the lung, and a delicate alveolo-capillary barrier brings circulating blood into close proximity to the inspired air...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28961337/early-hydrocortisone-improves-survival-without-bronchopulmonary-dysplasia-in-extremely-preterm-born-infants
#14
Alexander Rakow, Mikael Norman
No abstract text is available yet for this article.
September 29, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28957642/exosome-based-therapy-for-bronchopulmonary-dysplasia
#15
Michael A Matthay, Steven H Abman
No abstract text is available yet for this article.
September 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28950821/modelling-bronchopulmonary-dysplasia-in-animals-arguments-for-the-preterm-rabbit-model
#16
Thomas Salaets, Andre Gie, Bieke Tack, Jan Deprest, Jaan Toelen
Bronchopulmonary dysplasia (BPD) remains a frequent and disabling consequence of preterm birth, despite the recent advances in neonatal intensive care. There is a need to further improve outcomes and many novel therapeutic or preventive strategies are therefore investigated in animal models. We discuss in this review the aspects of human BPD pathophysiology and phenotype, which ideally should be mimicked by an animal model for this disease. Prematurity remains the common denominator in the heterogeneous spectrum of human BPD, and preterm animal models thus have a clear translational advantage...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28950234/effects-of-the-early-administration-of-sivelestat-sodium-on-bronchopulmonary-dysplasia-in-infants-a-retrospective-cohort-study
#17
Ryo Ogawa, Rintaro Mori, Koichi Iida, Yumiko Uchida, Makoto Oshiro, Misao Kageyama, Yuichi Kato, Taihei Tanaka, Yusei Nakata, Yutaka Nishimura, Isamu Hokuto, Motoki Bonno, Naoko Matsumoto, Masato Ito, Noriko Takahashi, Fumihiko Namba
BACKGROUND: Chorioamnionitis, or infiltration of the chorioamnion by neutrophils, is a risk factor associated with the development of bronchopulmonary dysplasia. Increased neutrophil elastase levels are observed in the tracheal aspirates of these patients. AIMS: To examine the effects of early administration of the selective neutrophil elastase inhibitor sivelestat, which is used to treat acute lung injury in adults, on bronchopulmonary dysplasia in extremely premature infants...
September 23, 2017: Early Human Development
https://www.readbyqxmd.com/read/28949375/runx3-is-a-key-modulator-during-the-epithelial-mesenchymal-transition-of-alveolar-type-ii-cells-in-animal-models-of-bpd
#18
Haiping Yang, Jianhua Fu, Li Yao, Ana Hou, Xindong Xue
Bronchopulmonary dysplasia (BPD) is a major challenge for premature infants; however, the underlying mechanisms remain unclear. We previously reported that epithelial-mesenchymal transition (EMT) in alveolar type II (AT2) epithelial cells influences the normal alveolar development process. In this study, we wished to examine whether Runx3 is an important factor for BPD by regulating EMT in AT2 cells. In vivo, animal models of BPD were established by placing newborn rats in hyperoxia tanks. Lung tissue and isolated AT2 cells were collected on different days following exposure to oxygen...
September 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28947055/can-we-prevent-bronchopulmonary-dysplasia
#19
Judy L Aschner, Eduardo H Bancalari, Cindy T McEvoy
No abstract text is available yet for this article.
October 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28945702/mesenchymal-stem-cells-in-the-pathogenesis-and-treatment-of-bronchopulmonary-dysplasia-a-clinical-review
#20
REVIEW
Ann A Simones, Daniel J Beisang, Angela Panoskaltsis-Mortari, Kari D Roberts
Advances in neonatal medicine have led to increased survival of infants born at the limits of viability resulting in an increased incidence of bronchopulmonary dysplasia (BPD). BPD is a chronic lung disease of premature infants characterized by arrest of alveolarization, fibroblast activation, and inflammation. BPD leads to significant morbidity and mortality in the neonatal period and is one of the leading causes of chronic lung disease in children. The past decade has brought a surge of trials investigating cellular therapies for the treatment of pulmonary diseases...
September 25, 2017: Pediatric Research
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