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Juvenile Idiopathic Arthritis

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https://www.readbyqxmd.com/read/29457995/validation-of-a-brazilian-portuguese-version-of-the-transition-readiness-assessment-questionnaire-traq-in-a-population-of-transitional-youth-with-chronic-rheumatologic-disorders
#1
Catherine G Anelli, Claudio A Len, Maria T Terreri, Gleice C S Russo, Andreas O Reiff
OBJECTIVE: To translate and validate the Brazilian Portuguese version of the Transition Readiness Assessment Questionnaire in a population of adolescents and young adults with chronic rheumatologic disorders. This questionnaire evaluates the patient's readiness for making the transition from the pediatric health service to adult care. METHODS: The four-phase methodology for the translation and validation of generic questionnaires was followed, including translation, back-translation, pilot testing and clinical validation of the final tool...
February 16, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29457372/clinical-characteristics-and-factors-associated-with-disability-and-impaired-quality-of-life-in-children-with-juvenile-systemic-sclerosis
#2
Brandi E Stevens, Kathryn S Torok, Suzanne C Li, Nicole Hershey, Megan Curran, Gloria C Higgins, Katharine F Moore, C Egla Rabinovich, Samuel Dodson, Anne M Stevens
OBJECTIVE: To investigate clinical manifestations of juvenile systemic sclerosis (jSSc), including disease characteristics and patient quality of life, through the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry. METHODS: Subjects with jSSc were prospectively enrolled between 2010 and 2013. Diagnosis of jSSc was determined by the enrolling pediatric rheumatologist, with disease onset required prior to age 18. Collected data included demographics, disease characteristics, medication exposure, and quality of life metrics...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29456387/clinico-epidemiological-profile-of-pediatric-rheumatology-disorders-in-eastern-india
#3
Pratap Kumar Patra, Manish Kumar
Background: Data on rheumatological disorders in children from developing countries like India are scarce. Hence, this study aimed to understand the clinical and epidemiological profile of rheumatological disorders in children as this can help organize comprehensive evidence-based health care services. Methodology: A retrospective hospital-based study was designed in pediatric rheumatology clinic of the All India Institute of Medical Sciences, Patna, India, from January 2015 to December 2016...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29455252/the-effect-of-anti-tumor-necrosis-factor-alpha-agents-on-the-outcome-in-pediatric-uveitis-of-diverse-etiologies
#4
Iris Deitch, Radgonde Amer, Oren Tomkins-Netzer, Zohar Habot-Wilner, Ronit Friling, Ron Neumann, Michal Kramer
PURPOSE: This study aimed to report the clinical outcome of children with uveitis treated with anti-tumor necrosis factor alpha (TNF-α) agents. METHODS: This included a retrospective cohort study. Children with uveitis treated with infliximab or adalimumab in 2008-2014 at five dedicated uveitis clinics were identified by database search. Their medical records were reviewed for demographic data, clinical presentation, ocular complications, and visual outcome. Systemic side effects and the steroid-sparing effect of treatment were documented...
February 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29453217/time-spent-in-inactive-disease-before-mtx-withdrawal-is-relevant-with-regard-to-the-flare-risk-in-patients-with-jia
#5
Jens Klotsche, Kirsten Minden, Martina Niewerth, Gerd Horneff
OBJECTIVES: To determine the reasons of methotrexate (MTX) discontinuation, frequency of adverse events (AE) and whether the time in inactive disease before MTX withdrawal disease is associated with the risk of disease flare. METHODS: Patients with juvenile idiopathic arthritis (JIA) beginning treatment with MTX were prospectively observed in the national JIA biologic register Biologika in der Kinderrheumatologie/Biologics in Paediatric Rheumatology and its follow-up register Juvenile arthritis Methotrexate/Biologics long-term Observation...
February 16, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29451845/relapse-of-juvenile-idiopathic-arthritis-associated-uveitis-after-discontinuation-of-immunomodulatory-therapy
#6
Nisha R Acharya, Sarju Patel, Gelareh Homayounfar, Wayne T A Enanoria, Akbar Shakoor, Anindita Chakrabarti, Debra A Goldstein
PURPOSE: To assess treatment outcomes in juvenile idiopathic arthritis (JIA)-associated uveitis and relapse rates upon discontinuation of immunomodulatory therapy (IMT). METHODS: Medical records of patients with JIA-associated uveitis seen at the University of Illinois at Chicago and the F.I. Proctor Foundation uveitis clinics from September 14, 1988 to January 5, 2011 were reviewed. The main outcome was time to relapse after attempting to discontinue IMT. RESULTS: Of 66 patients with JIA-associated uveitis, 51 (77%) received IMT as either sole or combination therapy...
February 16, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29440001/risk-of-malignancy-associated-with-paediatric-use-of-tumour-necrosis-factor-inhibitors
#7
Timothy Beukelman, Fenglong Xie, Lang Chen, Daniel B Horton, James D Lewis, Ronac Mamtani, Melissa M Mannion, Kenneth G Saag, Jeffrey R Curtis
OBJECTIVE: To determine whether tumour necrosis factor inhibitor (TNFi) use is associated with an increased rate of incident malignancy compared with no TNFi use in the treatment of juvenile idiopathic arthritis (JIA), paediatric inflammatory bowel disease (pIBD) and paediatric plaque psoriasis (pPsO). METHODS: We performed a retrospective cohort study of administrative claims data from the USA from 2000 to 2014. Exposure to TNFi was considered permanent from the first observed exposure onward...
February 9, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29439723/is-palindromic-rheumatism-amongst-children-a-benign-disease
#8
Yonatan Butbul-Aviel, Yosef Uziel, Nofar Hezkelo, Riva Brik, Gil Amarilyo
BACKGROUND: Palindromic rheumatism is an idiopathic, periodic arthritis characterized by multiple, transient, recurring episodes. Palindromic rheumatism is well-characterized in adults, but has never been reported in pediatric populations. The aim of this study was to characterize the clinical features and outcomes of a series of pediatric patients with palindromic rheumatism. METHODS: We defined clinical criteria for palindromic rheumatism and reviewed all clinical visits in three Pediatric Rheumatology centers in Israel from 2006through 2015, to identify patients with the disease...
February 13, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29437586/baseline-ultrasound-examination-as-possible-predictor-of-relapse-in-patients-affected-by-juvenile-idiopathic-arthritis-jia
#9
Orazio De Lucia, Viviana Ravagnani, Francesca Pregnolato, Arvena Hila, Irene Pontikaki, Maurizio Gattinara, Micol Romano, Valeria Gerloni, Sara Pieropan, Antonella Murgo, Maurizio Rossini, Rolando Cimaz, Pier Luigi Meroni
OBJECTIVES: To define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) and to assess whether synovitis detected by ultrasonography in clinically inactive patients predicts arthritis flares. METHODS: 88 consecutive patients with JIA-46 (52%) with persistent oligoarthritis, 15 (17%) with extended oligoarthritis, 15 (17%) with rheumatoid factor-negative polyarthritis and 12 (14%) with other forms of JIA, all clinically inactive for a minimum of 3 months-underwent ultrasound (US) assessment of 44 joints...
February 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29433504/successful-treatment-of-methotrexate-intolerance-in-juvenile-idiopathic-arthritis-using-eye-movement-desensitization-and-reprocessing-treatment-protocol-and-preliminary-results
#10
Lea Höfel, Bruno Eppler, Magdalena Storf, Elizabeth Schnöbel-Müller, Johannes-Peter Haas, Boris Hügle
BACKGROUND: Methotrexate (MTX), commonly used in juvenile idiopathic arthritis (JIA), frequently has to be discontinued due to intolerance with anticipatory and associative gastrointestinal adverse effects. Eye Movement Desensitization and Reprocessing (EMDR) is a psychological method where dysfunctional experiences and memories are reprocessed by recall combined with bilateral eye movements. The objective of this study was to assess efficacy of EMDR for treatment of MTX intolerance in JIA patients...
February 13, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29426067/neutrophils-in-systemic-onset-juvenile-idiopathic-arthritis-display-sepsis-like-features-which-can-be-reverted-by-il-1-blockade
#11
Nienke M Ter Haar, Tamar Tak, Michal Mokry, Rianne C Scholman, Jenny M Meerding, Wilco de Jager, Anouk Verwoerd, Dirk Foell, Thomas Vogl, Johannes Roth, Pieter H C Leliefeld, Jorg van Loosdregt, Leo Koenderman, Sebastiaan J Vastert, Sytze de Roock
OBJECTIVE: Neutrophils are the most abundant innate immune cells in the blood, however little is known about their role in (acquired) chronic autoinflammatory diseases. We investigated neutrophils in systemic onset Juvenile Idiopathic Arthritis (sJIA), a prototypical multifactorial autoinflammatory disease, characterized by arthritis and severe systemic inflammation. METHODS: We analyzed 50 sJIA patients at disease onset and during remission on recombinant IL-1 receptor antagonist (rIL-1RA, anakinra)...
February 9, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29426059/the-genetic-profile-of-rf-positive-polyarticular-juvenile-idiopathic-arthritis-jia-resembles-adult-rheumatoid-arthritis-ra
#12
Anne Hinks, Miranda C Marion, Joanna Cobb, Mary E Comeau, Marc Sudman, Hannah C Ainsworth, John Bowes, Mara L Becker, John F Bohnsack, Johannes-Peter Haas, Daniel J Lovell, Elizabeth D Mellins, J Lee Nelson, Ellen Nordal, Marilynn Punaro, Ann M Reed, Carlos D Rose, Alan M Rosenberg, Marite Rygg, Samantha L Smith, Anne M Stevens, Vibeke Videm, Carol A Wallace, Lucy R Wedderburn, Annie Yarwood, Rae Sm Yeung, Carl D Langefeld, Susan D Thompson, Wendy Thomson, Sampath Prahalad
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is comprised of seven heterogeneous categories of chronic childhood arthritides. About 5% of children with JIA have rheumatoid factor (RF) positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF-positive polyarticular JIA with RA, and selected other JIA categories, to more fully understand the pathophysiological relationships of inflammatory arthropathies...
February 9, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29423720/association-of-interferon-regulatory-factor-5-irf5-gene-polymorphisms-with-juvenile-idiopathic-arthritis
#13
Samira Esmaeili Reykande, Arezou Rezaei, Maryam Sadr, Mahsima Shabani, Farnaz Najmi Varzaneh, Vahid Ziaee, Nima Rezaei
Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play a fundamental role in its pathogenesis. In this study, we aimed to assess the association of IRF5 gene polymorphisms with susceptibility of JIA in Iranian population. Three IRF5 single-nucleotide polymorphisms (rs10954213 A/G, rs2004640 G/T, and rs3807306 G/T) were genotyped using TaqMan assays in 55 patients with JIA and 63 matched healthy individuals...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29422094/patient-s-experiences-with-the-care-for-juvenile-idiopathic-arthritis-across-europe
#14
E H Pieter van Dijkhuizen, Tsipi Egert, Yona Egert, Wendy Costello, Casper Schoemaker, Marlous Fernhout, Mirjam Kepic, Alberto Martini, Silvia Scala, Ingrid Rotstein-Grein, Sebastiaan J Vastert, Nico M Wulffraat
BACKGROUND: To assess the views of juvenile idiopathic arthritis (JIA) patients and their parents on the care and treatment they receive in referral pediatric rheumatology centers throughout Europe. METHODS: In a collaboration between physicians and patient associations, a questionnaire was developed, covering various domains of JIA care, including demographics, diagnosis, referrals to various health care professionals, access to pain and fatigue management and support groups, information they received about the disease and awareness of and participation in research...
February 8, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29420734/convergent-pathways-of-the-hyperferritinemic-syndromes
#15
Grant S Schulert, Scott W Canna
Hyperferritinemia and pronounced hemophagocytosis help distinguish a subset of patients with a particularly inflammatory and deadly systemic inflammatory response syndrome. Two clinically similar disorders typify these hyperferritinemic syndromes: hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS). HLH is canonically associated with a complete disturbance of perforin/granzyme-mediated cytotoxicity, whereas MAS occurs in the context of the related rheumatic diseases systemic juvenile idiopathic arthritis (SJIA) and adult-onset Still's disease (AOSD), with associated IL-1 family cytokine activation...
February 6, 2018: International Immunology
https://www.readbyqxmd.com/read/29420256/nicotinamide-phosphoribosyltransferase-deficiency-potentiates-the-anti-proliferative-activity-of-methotrexate-through-enhanced-depletion-of-intracellular-atp
#16
Rakesh K Singh, Leon van Haandel, Daniel P Heruth, Shui Q Ye, J Steven Leeder, Mara L Becker, Ryan S Funk
Lower plasma nicotinamide phosphoribosyltransferase (NAMPT) levels are associated with improved response to methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA). Cell-based studies confirmed that reduced cellular NAMPT activity potentiates the pharmacologic activity of MTX, however the mechanism of this interaction has yet to be defined. Therefore, in this study we investigate the mechanism of enhanced pharmacologic activity of MTX in NAMPT-deficient A549 cells. The siRNA-based silencing of NAMPT expression resulted in a greater than three-fold increase in the sensitivity to MTX (p<0...
February 2, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29419467/barriers-to-adherence-in-juvenile-idiopathic-arthritis-a-multicenter-collaborative-experience-and-preliminary-results
#17
Leslie A Favier, Janalee Taylor, Kristin Loiselle Rich, Karla B Jones, Sheetal S Vora, Julia G Harris, Beth S Gottlieb, Lisa Robbins, Jamie T Lai, Tzielan Lee, Melanie Kohlheim, Jennifer Gill, Laura Bouslaugh, Angela Young, Nancy Griffin, Esi M Morgan, Avani C Modi
OBJECTIVE: Nonadherence is currently an underrecognized and potentially modifiable obstacle to care in juvenile idiopathic arthritis (JIA). The purpose of our study was to design and implement a standardized approach to identifying adherence barriers for youth with JIA across 7 pediatric rheumatology clinics through the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) and to assess the frequency of adherence barriers in patients and their caregivers across treatment modalities...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29409136/novel-unc13d-intronic-variant-disrupting-a-nf%C3%AE%C2%BAb-enhancer-in-a-patient-with-recurrent-macrophage-activation-syndrome-and-systemic-juvenile-idiopathic-arthritis
#18
Grant S Schulert, Mingce Zhang, Ammar Husami, Ndate Fall, Hermine Brunner, Kejian Zhang, Randy Q Cron, Alexei A Grom
OBJECTIVE: Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (SJIA), and has pathologic similarity to hemophagocytic lymphohistiocytosis (HLH). Intronic variants in UNC13D are found in patients with familial HLH-3 (FHL3), but the role of non-coding variants in MAS is unknown. The objective of this study was to identify deep intronic UNC13D variants in patients with MAS. METHODS: A custom enrichment library was constructed to sequence approximately 1 MB flanking UNC13D in 24 patients with SJIA, recurrent MAS, and negative prior genetic (exon/coding) testing...
February 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29407498/no-association-between-types-of-unilateral-mandibular-condylar-abnormalities-and-facial-asymmetry-in-orthopedic-treated-patients-with-juvenile-idiopathic-arthritis
#19
Peter Bangsgaard Stoustrup, Nicole Ahlefeldt-Laurvig-Lehn, Kasper Dahl Kristensen, Linda Z Arvidsson, Marinka Twilt, Paolo M Cattaneo, Annelise Küseler, Anne Estmann Christensen, Troels Herlin, Thomas Klit Pedersen
INTRODUCTION: Dentofacial asymmetries are often observed in patients with juvenile idiopathic arthritis (JIA) and temporomandibular joint (TMJ) involvements. The aim of this split-face study was to associate types of radiologic TMJ abnormalities with the degree of dentofacial asymmetry in patients with unilateral TMJ involvements assessed with cone-beam computed tomography. METHODS: Forty-seven JIA patients and 19 nonarthritic control subjects were included in the study...
February 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29406303/yoga-intervention-for-an-adolescent-with-juvenile-idiopathic-arthritis-a-case-study
#20
Amanda B Feinstein, Lindsey L Cohen, Akihiko Masuda, Anya T Griffin, Kaitlyn L Gamwell, Mukunda T Stiles, Sheila T Angeles-Han, Sampath Prahalad
Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease associated with pain, stiffness, and psychosocial difficulties. The purpose of this case study was to investigate the impact of a yoga intervention on pain and morning stiffness in an adolescent female with JIA. A secondary aim was to assess the impact of this intervention on self-efficacy, mindfulness, health-related quality of life, and disease activity. A 17-y-old female with JIA participated in 3 yoga groups and home yoga practice with a digital video disc...
January 2018: Advances in Mind-body Medicine
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