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Juvenile Idiopathic Arthritis

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https://www.readbyqxmd.com/read/29031228/peptide-based-electrochemical-biosensor-for-juvenile-idiopathic-arthritis-detection
#1
V R Rodovalho, G R Araujo, E R Vaz, C Ueira-Vieira, L R Goulart, J M Madurro, A G Brito-Madurro
Juvenile idiopathic arthritis (JIA) is a wide group of diseases, characterized by synovial inflammation and joint tissue damage. Due to the delay in the implementation of biomarkers into clinical practice and the association with severe sequels, there is an imperative need for new JIA diagnosis strategies. Electrochemical biosensors based on screen-printed electrodes and peptides are promising alternatives for molecular diagnosis. In this work, a novel biosensor for detecting juvenile idiopathic arthritis (JIA) was developed based on the immobilization of the PRF+1 mimetic peptide, as recognition biological element, on the surface of screen-printed carbon electrode...
October 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29029101/growth-outcomes-after-gh-therapy-of-patients-given-long-term-corticosteroids-for-juvenile-idiopathic-arthritis
#2
Hélène David, Camille Aupiais, Baptiste Louveau, Pierre Quartier, Evelyne Jacqz-Aigrain, Jean-Claude Carel, Dominique Simon
Context: GH therapy may improve statural growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). Objectives: To evaluate the effect of GH treatment on adult height and to identify determinants of growth outcomes in JIA. Design and patients: Data from 58 JIA patients, including 53 given GH, enrolled in three prospective clinical trials between 1997 and 2002 were analyzed. Intervention: GH [0.056 mg/kg/d (IQR, 0...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29027570/are-we-right-to-consider-mesenchymal-stem-cells-to-be-a-new-perspective-for-patients-with-juvenile-idiopathic-arthritis
#3
REVIEW
Krzysztof Orczyk, Elzbieta Smolewska
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. MSCs can modulate inflammation via mechanisms of both adaptive and innate immune response. They are able to inhibit T and B cell proliferation, promote regulatory T cells, suppress the maturation of dendritic cells, stimulate macrophage differentiation into M2 phenotype and reduce effectiveness of natural killer cells...
October 13, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29025853/concomitant-administration-of-methotrexate-does-not-improve-efficacy-of-intra-articular-joint-injections-in-patients-with-oligoarticular-juvenile-idiopathic-arthritis
#4
William J Coles, Eslam Al-Abadi
No abstract text is available yet for this article.
October 12, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29025422/readout-segmented-multi-shot-diffusion-weighted-mri-of-the-knee-joint-in-patients-with-juvenile-idiopathic-arthritis
#5
Alexander Sauer, Mengxia Li, Annette Holl-Wieden, Thomas Pabst, Henning Neubauer
BACKGROUND: Diffusion-weighted MRI has been proposed as a new technique for imaging synovitis without intravenous contrast application. We investigated diagnostic utility of multi-shot readout-segmented diffusion-weighted MRI (multi-shot DWI) for synovial imaging of the knee joint in patients with juvenile idiopathic arthritis (JIA). METHODS: Thirty-two consecutive patients with confirmed or suspected JIA (21 girls, median age 13 years) underwent routine 1.5 T MRI with contrast-enhanced T1w imaging (contrast-enhanced MRI) and with multi-shot DWI (RESOLVE, b-values 0-50 and 800 s/mm(2))...
October 12, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29024575/genetics-and-the-classification-of-arthritis-in-adults-and-children
#6
REVIEW
Peter A Nigrovic, Soumya Raychaudhuri, Susan D Thompson
Current classification of primary inflammatory arthritis begins from the assumption that adults and children are different. No form of juvenile idiopathic arthritis bears the same name as an adult arthritis, a nomenclature gap with implications for both clinical care and research. Recent genetic data question this adult/pediatric divide, revealing instead broad patterns that span the age spectrum. Combining these genetic patterns with demographic and clinical data, we propose that inflammatory arthritis segregates into four main clusters, largely irrespective of pediatric or adult onset: seropositive, seronegative (likely including a distinct group that usually begins in early childhood), spondyloarthritis and systemic...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29022136/aortic-carotid-intima-media-thickness-and-flow-mediated-dilation-as-markers-of-early-atherosclerosis-in-a-cohort-of-pediatric-patients-with-rheumatic-diseases
#7
Emanuela Del Giudice, Anna Dilillo, Luciana Tromba, Giuseppe La Torre, Sara Blasi, Fabrizio Conti, Franca Viola, Salvatore Cucchiara, Marzia Duse
The aims of this study were to identify the presence of endothelial dysfunction as a marker of early atherosclerosis by measuring aortic and carotid intimal-medial thickness (aIMT and cIMT) and flow-mediated dilation (FMD) and their correlation with traditional and no traditional risk factors for atherosclerosis in children with rheumatic diseases. Thirty-nine patients (mean age 15.3 ± 5.7 years), 23 juvenile idiopathic arthritis, 9 juvenile spondyloarthropathies, 7 connective tissue diseases (mean disease duration and onset respectively 5 ± 3...
October 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29019476/parenting-a-child-with-juvenile-idiopathic-arthritis-orofacial-pain-and-dysfunction-a-qualitative-study
#8
Eva Leksell, Ulrika Hallberg, AnnaCarin Horne, Malin Ernberg, Britt Hedenberg-Magnusson
AIMS: To deepen knowledge of how parents of children diagnosed with juvenile idiopathic arthritis (JIA) perceive the orofacial manifestations of the disease, its treatments, and their encounters with dental care providers. METHODS: A total of 15 interviews with parents of JIA patients (3 to 16 years old) with orofacial pain were analyzed according to classic grounded theory. RESULTS: The main problem was identified as controlling an unpredictable life situation that includes a child with JIA...
October 10, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29018906/the-performance-of-classification-criteria-for-juvenile-spondyloarthropathies
#9
Amra Adrovic, Metin Sezen, Kenan Barut, Sezgin Sahin, Cengizhan Acikel, Erkan Demirkaya, Ozgur Kasapcopur
Juvenile spondyloarthropathies (JSpA) are a group of rheumatologic diseases with a disease onset before 16; characterized with enthesitis, lower extremity oligoarthritis, involvement of the axial skeleton and HLA B27 positivity. The diversity of classification criteria along with the phenotype heterogeneity makes the classification of JSpA challenging. The aim of our study was to evaluate the performance of the pre-determined and recently proposed classification criteria for JSpA. The study group consisted of 113 patients with JSpA and 150 patients with juvenile idiopathic arthritis (JIA)...
October 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28990337/the-prioritization-of-symptom-beliefs-over-illness-beliefs-the-development-and-validation-of-the-pain-perception-questionnaire-for-young-people
#10
Daniela Ghio, Wendy Thomson, Rachel Calam, Fiona Ulph, Eileen M Baildam, Kimme Hyrich, Lis Cordingley
OBJECTIVES: To investigate the suitability of the revised Illness Perception Questionnaire (IPQ-R) for use with adolescents with a long-term pain condition and to validate a new questionnaire for use with this age group. DESIGN: A three-phase mixed-methods study. METHODS: Phase 1 comprised in-depth qualitative analyses of audio-recorded cognitive interviews with 20 adolescents with juvenile idiopathic arthritis who were answering IPQ-R items...
October 9, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28990043/%C3%AE-he-genetics-of-juvenile-idiopathic-arthritis-searching-for-new-susceptibility-loci
#11
Maria I Zervou, Despoina G Dimopoulou, Elias Eliopoulos, Maria Trachana, Polyxeni Pratsidou-Gkertsi, Athena Andreou, Prodromos Sidiropoulos, Demetrios A Spandidos, Alexandros Garyfallos, George N Goulielmos
Juvenile idiopathic arthritis (JIA) is an autoimmune disease that is characterized by persistent chronic arthritis and affected by genetic and environmental factors. Different genetic variations have been reported as risk factors for JIA. However, given that many results could not be replicated in individuals of different ancestral origin, it was assumed that heterogeneous genetic factors are involved in this disease. In the present study, we analyzed three single nucleotide polymorphisms (SNPs), namely PTPRC (rs10919563), TYK2 (rs34536443) and PRKCQ (rs4750316), which were found to be associated with JIA in previous studies...
October 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28985804/adult-patients-with-uveitis-associated-with-juvenile-idiopathic-arthritis-a-retrospective-review
#12
Anton M Kolomeyer, Elliot S Crane, Yufei Tu, Dan Liu, David S Chu
OBJECTIVE: To describe clinical characteristics and outcomes of adults with uveitis associated with juvenile idiopathic arthritis (JIA). METHODS: Retrospective chart review from 2001 to 2014 of adult patients with JIA and follow-up ≥2 months. Outcome measures included visual acuity, intraocular pressure (IOP), inflammation grade, ocular findings/complications, immunosuppressive therapies, and surgeries. RESULTS: Nineteen patients were included (95% female, 84% bilateral uveitis, 47% anterior uveitis)...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28980895/systemic-onset-juvenile-idiopathic-arthritis-and-incomplete-kawasaki-disease-may-belong-to-a-single-clinical-syndrome-within-a-spectrum-of-severity
#13
Seung Beom Han, Soo Young Lee
No abstract text is available yet for this article.
October 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28978993/juvenile-idiopathic-arthritis-evidence-of-gut-driven-inflammation-in-new-jia
#14
Sarah Onuora
No abstract text is available yet for this article.
October 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28973842/flares-after-withdrawal-of-biologic-therapies-in-juvenile-idiopathic-arthritis-clinical-and-laboratory-correlates-of-remission-duration
#15
Gabriele Simonini, Giovanna Ferrara, Irene Pontikaki, Erika Scoccimarro, Teresa Giani, Andrea Taddio, Pier Luigi Meroni, Rolando Cimaz
OBJECTIVE: to assess the time in remission after discontinuing biologic therapy in JIA patients. METHODS: we enrolled 135 patients followed in three tertiary care centers. Primary outcome was to assess, once remission was achieved, the time in remission up to the first flare after discontinuing treatment. Mann-Whitney U-test, Wilcoxon signed-rank test for paired samples, chi-square, and Fisher's exact test were used to compare data. Pearson and Spearman correlation tests were used to determine correlation coefficients for different variables...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28973482/high-throughput-characterization-of-the-functional-impact-of-igg-fc-glycan-aberrancy-in-juvenile-idiopathic-arthritis
#16
Hao D Cheng, Henning Stöckmann, Barbara Adamczyk, Ciara A McManus, Altan Ercan, Ingrid A Holm, Pauline M Rudd, Margaret E Ackerman, Peter A Nigrovic
Juvenile idiopathic arthritis (JIA) encompasses all forms of chronic idiopathic arthritis that arise before age 16. Previous studies have found JIA to be associated with lower Fc galactosylation of circulating IgG, but the overall spectrum of glycan changes and the net impact on IgG function are unknown. Using ultra performance liquid chromatography (UPLC), we compared IgG glycosylation in 54 subjects with recent-onset untreated JIA with 98 healthy pediatric controls, paired to biophysical profiling of affinity for 20 IgG receptors using a high-throughput multiplexed microsphere assay...
September 14, 2017: Glycobiology
https://www.readbyqxmd.com/read/28969936/the-dna-methylation-landscape-of-cd4-t-cells-in-oligoarticular-juvenile-idiopathic-arthritis
#17
Raul A Chavez-Valencia, Rachel C Chiaroni-Clarke, David J Martino, Jane E Munro, Roger C Allen, Jonathan D Akikusa, Anne-Louise Ponsonby, Jeffrey M Craig, Richard Saffery, Justine A Ellis
Juvenile idiopathic arthritis (JIA) is presumed to be driven by an adverse combination of genes and environment. Epigenetic processes, including DNA methylation, act as a conduit through which the environment can regulate gene activity. Altered DNA methylation has been associated with adult autoimmune rheumatic diseases such as rheumatoid arthritis, but studies are lacking for paediatric autoimmune rheumatic diseases including JIA. Here, we performed a genome-scale case-control analysis of CD4(+) T cell DNA methylation from 56 oligoarticular JIA (oJIA) cases and 57 age and sex matched controls using Illumina HumanMethylation450 arrays...
September 29, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28967364/open-issues-in-the-assessment-and-management-of-pain-in-juvenile-idiopathic-arthritis
#18
REVIEW
Gabriella Giancane, Alessandra Alongi, Silvia Rosina, Serena Calandra, Alessandro Consolaro, Angelo Ravelli
Pain is the major symptom of children with juvenile idiopathic arthritis (JIA) and its reduction is a key goal of treatment. It is widely agreed that assessment of pain is a fundamental component of the rheumatology evaluation and should be carried out at each clinic visit. However, so far there has been insufficient attention to the impact and causes of pain in children with chronic arthritis in both clinical practice and research. Quantitative measures of pain are seldom used regularly in daily care and pain assessment has not been incorporated in the most popular composite outcome measures for JIA, including the criteria employed to measure improvement in therapeutic trials...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28957547/increased-autophagy-contributes-to-the-inflammatory-phenotype-of-juvenile-idiopathic-arthritis-synovial-fluid-t-cells
#19
Janneke G C Peeters, Nienke de Graeff, Martin Lotz, Salvatore Albani, Sytze de Roock, Jorg van Loosdregt
Objectives: JIA is an autoimmune disease involving disturbed T-cell homeostasis, marked by highly activated effector T cells. Autophagy, a lysosomal degradation pathway, is crucial for maintaining cellular homeostasis by regulating the survival, differentiation and function of a large variety of cells, including T cells. The aim of this study was to examine the rate of autophagy in JIA T cells and to investigate the effect of inhibition of autophagy on the inflammatory phenotype of JIA T cells...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28955492/prongf-p75ntr-axis-plays-a-proinflammatory-role-in-inflamed-joints-a-novel-pathogenic-mechanism-in-chronic-arthritis
#20
Gaetana Minnone, Marzia Soligo, Ivan Caiello, Giusi Prencipe, Luigi Manni, Denise Pires Marafon, Silvia Magni-Manzoni, Antonio Manzo, Fabrizio De Benedetti, Luisa Bracci-Laudiero
OBJECTIVE: To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. METHODS: Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue and cells of patients with juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA), and controls. RESULTS: proNGF and not mNGF is the prevalent form measured in synovial fluids of patients with JIA and RA with synovial fibroblasts as a major source of proNGF in the inflamed synoviae...
2017: RMD Open
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